5,420 results match your criteria Anesthesia Topical


Effect of Topical Anesthesia on the Secretory Activity of the Main Lacrimal Gland.

Cornea 2020 Jun 30. Epub 2020 Jun 30.

Centre for Ocular Regeneration, L V Prasad Eye Institute, Hyderabad, India.

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http://dx.doi.org/10.1097/ICO.0000000000002410DOI Listing

Effect of precooling on pain during local anesthesia administration in children: a systematic review.

J Dent Anesth Pain Med 2020 Jun 24;20(3):119-127. Epub 2020 Jun 24.

Department of Pedodontics & Preventive Dentistry, Malla Reddy Dental College for Women, Hyderabad, Telangana, India.

This study was conducted to determine how precooling reduces the subjective reported pain and objective pain and to evaluate the effectiveness of precooling the injection site before administration of local anesthesia in children. Electronic databases (PubMed, Ovid SP, Cochrane Central Register of Controlled Trials) were searched for publications from 1980 to 2020. Studies were screened for titles and abstracts, followed by full-text evaluation of included reports. Read More

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http://dx.doi.org/10.17245/jdapm.2020.20.3.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321740PMC

A comparative evaluation of pain perception following topical application of benzocaine gel, clove-papaya based anesthetic gel and precooling of the injection site before intraoral injections in children.

J Indian Soc Pedod Prev Dent 2020 Apr-Jun;38(2):184-189

Department of Pedodontics and Preventive Dentistry, DAPM R V Dental College, Bengaluru, Karnataka, India.

Background And Aim Of The Study: The topical anesthetic property of clove remains unexplored even though it has been widely used in dentistry since ages. Hence, the aim of the study was to compare the topical anesthetic efficiency of precooling with ice, clove-papaya based topical gel and benzocaine gel in pediatric patients.

Methodology: Sixty healthy children aged 9-10 years who required local anesthetic injections for dental procedures were selected and divided into three groups with 20 patients each. Read More

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http://dx.doi.org/10.4103/JISPPD.JISPPD_153_18DOI Listing

Comparative evaluation of a novel herbal anesthetic gel and 2% lignocaine gel as an intraoral topical anesthetic agent in children: Bilateral split-mouth, single-blind, crossover study.

J Indian Soc Pedod Prev Dent 2020 Apr-Jun;38(2):177-183

Department of Pediatric and Preventive Dentistry, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

Background: Topical anesthetics have an intrinsic part to reduce pricking pain sensation due to needle stick before injection in children.

Aim: The present study aimed to determine the effectiveness of a novel herbal anesthetic gel used as a topical anesthetic before an inferior alveolar nerve block.

Settingsanddesign: This was a bilateral split-mouth, single blind, crossoverin vivo study. Read More

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http://dx.doi.org/10.4103/JISPPD.JISPPD_226_20DOI Listing

Barriers and facilitators to effective procedural pain treatments for pediatric patients in the Chinese context: A qualitative descriptive study.

J Pediatr Nurs 2020 Jun 22;54:78-85. Epub 2020 Jun 22.

School of Nursing, University of Ottawa, 451 Smyth Road, Ottawa K1H 8M5, Ontario, Canada; Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Rd, Ottawa K1H 8L1, Ontario, Canada; School of Nursing, The University of Melbourne, 161 Barry Street, Victoria 3010, Australia.

Purpose: To explore nurse and physician leaders' perceptions of barriers and facilitators to using evidence-based procedural pain treatments (i.e., sweet solutions, breastfeeding, and topical anesthetics) for hospitalized infants and children in the Chinese context. Read More

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http://dx.doi.org/10.1016/j.pedn.2020.06.004DOI Listing

The safety of topical lidocaine for awake tracheal intubation: a reply.

Anaesthesia 2020 Jun 25. Epub 2020 Jun 25.

Guy's and St Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/anae.15101DOI Listing

Defining the Most Effective Patient Blood Management Combined with Tranexamic Acid Regime in Primary Uncemented Total Hip Replacement Surgery.

J Clin Med 2020 Jun 22;9(6). Epub 2020 Jun 22.

Department of Orthopaedics, Hospital Universitario "La Paz", IdiPAZ, and Autónoma University, 28046 Madrid, Spain.

The application of patient blood management (PBM) combined with tranexamic acid administration (TXA) results in decreased total blood loss volume (TVB) and transfusions in total hip replacements (THRs). Dosages, timing, and routes of administration of TXA are still under debate as all these aspects, as well as interpatient variations, may affect the efficacy of the protocol. This study aims to examine the effectiveness of timing and route of administration of TXA in combination with PBM by reducing the TBV following THR surgery. Read More

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http://dx.doi.org/10.3390/jcm9061952DOI Listing

High frequency jet ventilation at the distal end of tracheostenosis during flexible bronchoscopic resection of large intratracheal tumor: Case series.

Medicine (Baltimore) 2020 Jun;99(25):e19929

Department of Anesthesiology.

Introduction: Resection of a large intratracheal tumor with severe obstruction via flexible bronchoscope remains a formidable challenge to anesthesiologists. Many artificial airways positioned proximal to tracheal obstruction can not ensure adequate oxygen supply. How to ensure effective gas exchange is crucial to the anesthetic management. Read More

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http://dx.doi.org/10.1097/MD.0000000000019929DOI Listing

Optimization of a Rabbit Dry Eye Model Induced by Topical Instillation of Benzalkonium Chloride.

J Ophthalmol 2020 30;2020:7204951. Epub 2020 May 30.

Department of Optometry and Vision, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain.

Purpose: To optimize a rabbit dry eye model induced by topical instillation of benzalkonium chloride (BAC), reduce the days of instillation of the original model by increasing the concentration of BAC from 0.1% to 0.2%. Read More

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http://dx.doi.org/10.1155/2020/7204951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277021PMC

Efficacy of Er,Cr:YSGG laser-assisted delivery of topical anesthesia in the oral mucosa.

Clin Oral Investig 2020 Jun 18. Epub 2020 Jun 18.

, Tehran, Iran.

Objective: Lasers which can reduce epithelium thickness will enhance the penetration of topical drugs. To date, no study has assessed the efficacy of this technique in the oral mucosa. The aim of this study was the evaluation of efficacy of this technique in increasing the effect of topical anesthesia in the oral mucosa. Read More

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http://dx.doi.org/10.1007/s00784-020-03399-xDOI Listing

Successful treatment of ciliary body medulloepithelioma with intraocular melphalan chemotherapy: a case report.

BMC Ophthalmol 2020 Jun 18;20(1):239. Epub 2020 Jun 18.

Department of Ophthalmology, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Avenue de France 15, 1000, Lausanne 7, Vaud, Switzerland.

Background: Intraocular medulloepithelioma is commonly treated with primary enucleation. Conservative treatment options include brachytherapy, local resection and/or cryotherapy in selected cases. We report for the first time the use of targeted chemotherapy to treat a ciliary body medulloepithelioma with aqueous and vitreous seeding. Read More

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http://dx.doi.org/10.1186/s12886-020-01512-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302148PMC

Pain control after laparoscopic cholecystectomy. A prospective study.

Ann Ital Chir 2020 Jun 10;9. Epub 2020 Jun 10.

Aim: The purpose of this study is to evaluate three different analgesic procedures after laparoscopic cholecystectomy for pain control.

Material Of Study: The study involved 183 patients who underwent laparoscopic cholecystectomy with the same technique for the induction and maintenance of the general anesthesia. They were divided into three different postoperative pain treatment groups: continuous infusion of Tramadol and Ketorolac with elastomeric pump, intraperitoneal topical instillation of Levobupivacaine, and intraperitoneal aerosolization of Levobupivacaine. Read More

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The use of high dose topical capsaicin in the management of peripheral neuropathy: narrative review and local experience.

Br J Pain 2020 May 15;14(2):133-140. Epub 2020 Apr 15.

Great Ormond Street Hospital, London, UK.

Capsaicin, derived from the chilli pepper plant, is available in high concentration (8%) patches to provide topical therapy for neuropathic pain. Its analgesic effects relate to defunctionalisation and nerve terminal retraction of predominantly C fibres in the dermis and epidermis. Systematic reviews and meta-analysis support its use for the management of post-herpetic neuralgia and HIV neuropathy with some evidence for use in painful peripheral diabetic neuropathy. Read More

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http://dx.doi.org/10.1177/2049463720914332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265596PMC

Palatal needle-free anesthesia for upper molars extraction. A randomized clinical trial.

J Craniomaxillofac Surg 2020 May 11. Epub 2020 May 11.

Federal University of Sergipe, Oral Surgery and Anesthesiology Area of Dentistry Department, St Cláudio Batista, 49060-108, Aracaju, Cidade Nova, Sergipe, Brazil.

Background: The aim of this study was to compare the ability of liposomal and non-liposomal lidocaine and prilocaine in hydrogel formulations to promote topical anesthesia in palatal mucosa during upper molar extractions.

Methods: In this randomized, cross over, triple-blinded clinical trial, a liposomal and a non-liposomal formulation of the eutectic mixture of local anesthetics, 2.5% lidocaine and 2. Read More

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http://dx.doi.org/10.1016/j.jcms.2020.05.001DOI Listing

Evaluation of biochemical parameters in Rubus tereticaulis treated rats and its implications in wound healing.

Mol Cell Biochem 2020 Jun 10. Epub 2020 Jun 10.

Department of Biochemistry, Faculty of Pharmacy, Marmara University, Tibbiye Cad. No: 49, Haydarpasa, 34668, Istanbul, Turkey.

We evaluated the effects of Rubus tereticaulis in healing process by determining the total carbonyl content, collagen synthesis, and total protein level on rat wounded tissues. Wounds were performed in the back of 54 Wistar rats, using a biopsy punch instrument with 0.6 mm in diameter. Read More

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http://dx.doi.org/10.1007/s11010-020-03784-wDOI Listing

Silver Diamine Fluoride Helps Prevent Emergency Visits in Children with Early Childhood Caries.

Pediatr Dent 2020 May;42(3):217-220

Dr. Tomar is a professor and Dean of Prevention and Public Health Sciences, University of Illinois at Chicago College of Dentistry, Chicago, Ill., USA;, Email:

Early childhood caries remains a worldwide disease and often requires treatment under sedation or general anesthesia, with long waitlists. Silver diamine fluoride has been shown to arrest caries lesions. The purpose of this study was to determine whether silver diamine fluoride (SDF) application reduces emergency visits by waitlisted patients with early childhood caries (ECC). Read More

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Does topical local anaesthesia reduce the pain and distress of nasogastric tube insertion in children?

Arch Dis Child 2020 Jul 4;105(7):697-700. Epub 2020 Jun 4.

Paediatrics, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1136/archdischild-2020-319197DOI Listing

Methemoglobinemia: A Life-threatening Complication of Topical Pharyngeal Anesthetics.

Cureus 2020 Apr 30;12(4):e7900. Epub 2020 Apr 30.

Gastroenterology, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.

Drug-induced methemoglobinemia can be caused due to topical anesthetics, dapsone, nitrates (e.g., nitroglycerin), and metoclopramide. Read More

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http://dx.doi.org/10.7759/cureus.7900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263402PMC

Corneal perforation associated with isolated ocular lichen planus: a case report.

Eur J Ophthalmol 2020 Jun 3:1120672120932089. Epub 2020 Jun 3.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Mexico.

Introduction: To report a case of unilateral corneal perforation due to isolated ocular lichen planus.

Methods: Interventional case report. Informed consent by the patient was obtained to publish clinical images. Read More

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http://dx.doi.org/10.1177/1120672120932089DOI Listing

All India Ophthalmological Society members' survey: Practice pattern of intravitreal anti-vascular endothelial growth factor injection.

Indian J Ophthalmol 2020 Jun;68(6):1095-1098

Dr. RP Centre for Ophthalmic Sciences, All India Institute of Ophthalmic Sciences, New Delhi, India.

Purpose: The aim of this paper is to report the results of an on-line survey to evaluate the practice pattern of Indian retina specialists in administering intravitreal anti-vascular endothelial growth factor injection.

Methods: A structured questionnaire on the intravitreal injection (IVI) procedure protocols was sent online to all members of the All India Ophthalmological Society (AIOS) with a request to the retina specialists to respond. A unique link that directed to the web-based questionnaire page allowed a single response only. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1602_19DOI Listing

Articulation lost in space. The effects of local orobuccal anesthesia on articulation and intelligibility of phonemes.

Brain Lang 2020 Aug 20;207:104813. Epub 2020 May 20.

Department of Neurology, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium. Electronic address:

Motor speech requires numerous neural computations including feedforward and feedback control mechanisms. A reduction of auditory or somatosensory feedback may be implicated in disorders of speech, as predicted by various models of speech control. In this paper the effects of reduced somatosensory feedback on articulation and intelligibility of individual phonemes was evaluated by using topical anesthesia of orobuccal structures in 24 healthy subjects. Read More

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http://dx.doi.org/10.1016/j.bandl.2020.104813DOI Listing

No-flip ShangRing circumcision in 10-12 year old boys: Results from randomized clinical trials in Kenya.

PLoS One 2020 22;15(5):e0233150. Epub 2020 May 22.

Department of Urology, James Buchanan Brady Foundation, Center for Male Reproductive Medicine and Microsurgery, Weill Cornell College of Cornell University, New York, NY, United States of America.

Background: Attention has recently turned toward the use of device-assisted male circumcision to help scale up male circumcision services in sub-Saharan Africa, with increasing emphasis on younger age groups. We assessed the use of the ShangRing for circumcising the subset of boys aged 10 to 12 years who were enrolled in two randomized clinical trials in Kenya.

Methods: We performed a sub-analysis of outcomes in 197 boys aged 10 to 12 years; a subset who were enrolled in two randomized clinical trials to assess the use of the no-flip ShangRing circumcision technique in men and boys. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233150PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244118PMC

The Use of Topical Nitroglycerin to Facilitate Radial Arterial Catheter Insertion in Children: A Randomized Controlled Trial.

J Cardiothorac Vasc Anesth 2020 Apr 29. Epub 2020 Apr 29.

Department of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.

Objectives: To determine whether the use of topical nitroglycerin patch increases radial artery diameter and facilitate cannulation in children.

Design: Randomized controlled trial.

Setting: Cairo University Hospital. Read More

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http://dx.doi.org/10.1053/j.jvca.2020.04.035DOI Listing

How does the COVID-19 pandemic affect the preoperative evaluation and anesthesia applied for urinary stones? EULIS eCORE-IAU multicenter collaborative cohort study.

Urolithiasis 2020 Aug 20;48(4):345-351. Epub 2020 May 20.

Department of Urology, School of Medicine, Medicana Bahcelievler Hospital, Biruni University, Istanbul, Turkey.

Stone disease is a unique condition that requires appropriate management in a timely manner as it can result in both emergent conditions and long term effects on kidney functions. In this study it is aimed to identify the up-to-date practice patterns related to preoperative evaluation and anesthesia for stone disease interventions during COVID-19 pandemic. The data of 473 patients from 11 centers in 5 different countries underwent interventions for urinary stones during the Covid-19 pandemic was collected and analyzed retrospectively. Read More

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http://dx.doi.org/10.1007/s00240-020-01193-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239347PMC

Flexible Endoscopic Biopsy: Identifying Factors to Increase Accuracy in Diagnosing Benign and Malignant Laryngopharyngeal Pathology.

J Voice 2020 May 17. Epub 2020 May 17.

Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.

Objectives: To assess the influence that several factors, such as the amount of obtained biopsies, difficult procedures, biopsy site and the experience of the attending physician, have on accuracy of flexible endoscopic biopsy (FEB).

Materials And Methods: 203 FEB procedures for benign or malignant laryngopharyngeal lesions were prospectively included. During the procedure, three representative biopsies (macroscopically containing vital tumor tissue and not only necrosis or healthy tissue) were obtained. Read More

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http://dx.doi.org/10.1016/j.jvoice.2020.04.015DOI Listing

[Assessment of Langerhans Cells in the Central Cornea as Tool for Monitoring Inflammatory Changes in Patients with Keratoconjunctivitis sicca under Topical Therapy with Cyclosporine A 0.05% Eye Drops].

Klin Monbl Augenheilkd 2020 May 20;237(5):669-674. Epub 2020 May 20.

AUGEN & HAUT - Praxis Dr. Jacobi, Nürnberg, Deutschland.

Background: Keratoconjunctivitis sicca is one of the most common ocular diseases and is associated with a considerable decrease in the quality of life. It is accompanied by symptoms of discomfort, tear film instability, hyperosmolarity of the tear film, inflammation of the ocular surface and neurosensory abnormalities. It is still not clear yet if the density of Langerhans cells in the central cornea can be used for objective evaluation of the inflammation in the tear film and the ocular surface. Read More

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http://dx.doi.org/10.1055/a-1155-6519DOI Listing

[Quality Management at the Eye Centre of Freiburg University Hospital: Does it Help to Use Quality Parameters?]

Klin Monbl Augenheilkd 2020 May 20. Epub 2020 May 20.

Klinik für Augenheilkunde, Albert-Ludwigs-Universität Freiburg, Medizinische Fakultät.

Background: All hospitals in Germany have a legal obligation to carry out internal quality management (QM). This means enormous costs as well as a burden for the employees through QM-specific tasks. The benefits can be advertising through certification, higher quality and safety for the treated patients and thus greater patient and employee satisfaction. Read More

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http://dx.doi.org/10.1055/a-1141-3873DOI Listing

Successful topical treatment of anal giant condylomata acuminata in an infant.

Dermatol Ther 2020 May 19:e13624. Epub 2020 May 19.

Dermatology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Anogenital condylomata acuminata are induced by human papillomavirus (HPV) and they rarely manifest in immunocompetent children. Therapeutic options depend on patient's age and general conditions and extension of the lesions. However, management is still a challenge and recurrences are frequent. Read More

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http://dx.doi.org/10.1111/dth.13624DOI Listing

Combination of Lidocaine Gel and Povidone-Iodine to Decrease Acquired Infections in Procedures Performed Using Topical Anesthesia.

J Cataract Refract Surg 2020 May 15. Epub 2020 May 15.

From Emory University School of Medicine (Xia, Lyons, Lin), Department of Ophthalmology, Emory University School of Medicine (Khalifa), Department of Ophthalmology, Grady Memorial Hospital (Khalifa), Department of Microbiology and Immunology (LaRock), Emory University School of Medicine, Division of Infectious Disease (LaRock), Emory University School of Medicine, Emory Antibiotic Resistance Center (LaRock), Atlanta, Georgia, USA.

Purpose: To test the antiseptic efficacy of povidone-iodine when mixed with topical lidocaine gel .

Setting: Emory School of Medicine, Atlanta, Georgia, USA.

Design: Experimental study. Read More

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http://dx.doi.org/10.1097/j.jcrs.0000000000000245DOI Listing

Use of Purastat, a novel haemostatic matrix based on self-assembling peptides in the prevention of nasopharyngeal adhesion formation.

Int J Surg Case Rep 2020 8;70:227-229. Epub 2020 May 8.

Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, University of Sydney, Camperdown, NSW, Australia.

Introduction: Purastat is a novel haemostatic agent that has recently been used effectively in nasal procedures, specifically in functional endoscopic endonasal surgery in the prevention of post-operative epistaxis while minimising adhesion formation. This study presents a case of successful application of Purastat following division of a nasopharyngeal/palatal stenosis following radiotherapy.

Presentation Of Case: A 49-year-old male developed severe nasopharyngeal stenosis following concurrent chemoradiotherapy with curative intent a HPV positive base of tongue squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231812PMC

Management of diabetic foot ulcers: a 25% lidocaine topical cream formulation design, physicochemical and microbiological assessments.

Eur J Hosp Pharm 2020 May 12;27(3):162-167. Epub 2018 Nov 12.

Département de Pharmacie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Paris, France.

Background: Given the importance of surgical debridement in healing of diabetic foot ulcers, effective local anaesthesia is required to manage the related extreme pain. The pharmaceutical proprietary products currently available have low concentrations and do not exceed 5% w/w local anaesthetic.

Objective: Formulation design of a lidocaine cream of 25% and assessment of the intrinsic stability. Read More

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http://dx.doi.org/10.1136/ejhpharm-2018-001680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223286PMC

Physician Attitudes and Perceptions of Complementary and Alternative Medicine (CAM): A Multicentre Italian Study.

Front Oncol 2020 28;10:594. Epub 2020 Apr 28.

Medical Oncology, Department of Uro-Gynaecological Oncology 'Istituto Nazionale Tumori' 'Fondazione G. Pascale' IRCCS, Naples, Italy.

Complementary and Alternative Medicine (CAM) interventions are widely used by patients with chronic disorders, including cancer, and may interact with cancer treatment. Physicians are often unaware of this, probably due to poor patient-physician communication on CAM. The purpose of this study was to evaluate physicians' knowledge, attitudes and practice patterns regarding CAM in a survey conducted in Italy. Read More

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http://dx.doi.org/10.3389/fonc.2020.00594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202223PMC

Successful Treatment of Pigmentary Disorders in Asians With a Novel 730-nm Picosecond Laser.

Lasers Surg Med 2020 May 14. Epub 2020 May 14.

Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.

Background And Objective: Until recently, quality-switched nanosecond lasers have been the workhorse lasers in treating pigmented lesions. However, the recently commercialized picosecond lasers have provided physicians with a novel method to manage pigmented lesions. Most recently, the first picosecond laser with a 730-nm wavelength was developed to specifically target melanin and melanocytes. Read More

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http://dx.doi.org/10.1002/lsm.23261DOI Listing

Intracameral Triamcinolone Acetonide Versus Topical Dexamethasone: A Comparison of Anti-inflammatory Effects After Phacoemulsification.

Cureus 2020 Apr 8;12(4):e7592. Epub 2020 Apr 8.

Anesthesia and Critical Care, Chaudhry Pervaiz Elahi Institute of Cardiology, Multan, PAK.

Study objective and design The objective of this study was to determine the effectiveness of triamcinolone acetonide when used as a single dose as compared to the topical use of dexamethasone to control the inflammation after phacoemulsification. The study was a randomized controlled trial conducted in the Department of Ophthalmology at the District Headquarter (DHQ) Teaching Hospital, Dera Ghazi Khan, from March 1, 2018, to August 31, 2019. Materials and methods Eighty patients were included in the study. Read More

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http://dx.doi.org/10.7759/cureus.7592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212759PMC

A new two-step anesthesia for 23- or 25-gauge vitrectomy surgery: A prospective, randomized clinical trial.

Ophthalmic Res 2020 May 8. Epub 2020 May 8.

Objective:To investigate the safety and efficacy of topical anesthesia combined with sub-conjunctival anesthesia (termed two-step anesthesia) for 23- or 25-gauge pars plana vitrectomy or other posterior segment surgery. Methods:Patients (n = 90) requiring 23-/25- vitrectomy or other posterior segment surgery were randomized into three groups. Group 1 received peribulbar anesthesia, Group 2 received retrobulbar anesthesia and Group 3 received two-step anesthesia. Read More

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http://dx.doi.org/10.1159/000508510DOI Listing
May 2020
1.376 Impact Factor

Safe short circuit in cataract surgery: incidence and risk factors for intraoperative medical action.

Anaesth Crit Care Pain Med 2020 May 5. Epub 2020 May 5.

Department of Neurosurgical Anaesthesiology and Critical Care Pitié-Salpêtrière Hospital, Paris, France.

Cataract surgery has become the most frequent surgical procedure performed every year in Western countries. Perioperative patient circuit has to be adapted to the important medical needs and progress. Hence, a secure short circuit (SSC) for surgeries of the anterior segment of the eye under topical anaesthesia was created. Read More

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http://dx.doi.org/10.1016/j.accpm.2020.01.008DOI Listing

Dry anophthalmic socket syndrome - Standardized clinical evaluation of symptoms and signs.

Ocul Surf 2020 07 6;18(3):453-459. Epub 2020 May 6.

Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany; Center for Integrated Oncology (CIO) Aachen-Bonn-Cologne-Dusseldorf, Cologne, Germany.

Objectives: To assess symptoms and signs of the dry anophthalmic socket syndrome (DASS) in a standardized manner.

Methods: 87 unilateral anophthalmic patients were evaluated using the Ocular Surface Disease Index (OSDI), the 5-Item Dry Eye Questionnaire (DEQ-5), and a modified version of Symptom Assessment iN Dry Eye (SANDE) questionnaire separately for the anophthalmic socket and for the healthy fellow eye. Conjunctival inflammation was semi-quantitatively graded and Schirmer I test with topical anesthesia was performed bilaterally. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.05.001DOI Listing

Acute cortisol and behavior of dairy goat kids administered local anesthesia, topical anesthesia or systemic analgesia prior to cautery disbudding.

Physiol Behav 2020 Aug 6;222:112942. Epub 2020 May 6.

Veterinary Diagnostics and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1809 South Riverside Drive, Ames, IA, United States. Electronic address:

Cautery disbudding of goat kids causes thermal burns and tissue destruction, which results in acute and post-operative pain and negatively affects animal welfare. The objectives of this study were to evaluate acute cortisol concentrations and behavioral responses associated with (1) injecting a lidocaine ring block prior to cautery disbudding and comparing this to saline injections and (2) pain mitigation strategies (lidocaine ring block, topical eutectic mixture of local anesthetics (EMLA) cream, oral meloxicam) on cautery disbudded dairy goat kids. Sixty doe kids were allocated to one of six treatments: (1) disbudding without pain relief (DB), (2) a ring block using 1% lidocaine (DBLA) 20 min before disbudding, (3) saline injection (DBSA) 20 min before disbudding, (4) oral meloxicam 60 min before disbudding (DBMEL), (5) EMLA cream rubbed into the buds 60 min before disbudding (DBEM) and (6) handled but not disbudded (HAND). Read More

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http://dx.doi.org/10.1016/j.physbeh.2020.112942DOI Listing

The effect of pre-anesthesia with a needle-free system versus topical anesthesia on injection pain of the inferior alveolar nerve block: a randomized clinical trial.

Clin Oral Investig 2020 May 7. Epub 2020 May 7.

Department of Pediatric Dentistry, Faculty of Dentistry, Istanbul Okan University, Istanbul, Turkey.

Objective: The aim of this study was to compare the effectiveness of pain control between a needle-free system and topical anesthesia applied prior to inferior alveolar nerve block (IANB).

Materials And Methods: The present study was designed as a randomized controlled cross-over clinical study on 60 children (aged 6 to 12 years) requiring dental treatment with IANB in bilateral mandibular molars. As pre-anesthesia, topical anesthesia (TA) was applied on one side and the Comfort-in™ injection system (CIS) on the other side in two separate sessions before IANB. Read More

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http://dx.doi.org/10.1007/s00784-020-03301-9DOI Listing

Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing Cataract Surgery: A Randomized Controlled Trial.

Front Pharmacol 2020 16;11:440. Epub 2020 Apr 16.

Department of General Ophthalmology, Medical University of Lublin, Lublin, Poland.

Purpose: To assess the pain intensity of two intracameral anesthetic solutions in patients undergoing cataract surgery and evaluate the factors influencing the patients' postoperative activities.

Methods: Sixty-two patients undergoing cataract surgery were randomized to receive the study drug - a manufactured solution of 0.02% tropicamide/0. Read More

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http://dx.doi.org/10.3389/fphar.2020.00440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176993PMC

Systematic endoscopic assessment of bleeding sites in severe epistaxis: the role of the S-point and the superior epistaxis.

Rhinology 2020 05 5. Epub 2020 May 5.

Federal University of Sao Paulo (UNIFESP-EPM), Department of Otorhinolaryngology and Head and Neck Surgery, Sao Paulo, SP, Brazil.

Background: Systematic endoscopic assessment (SEA) of bleeding sites is critical for topodiagnosis and treatment of severe epistaxis, which is not limited to the posterior region. A bleeding site originating from the ethmoidal vasculature, the S-point, has recently been described. The aim of this study is to ascertain the prevalence of each bleeding site in severe epistaxis using a SEA protocol that includes the S-point. Read More

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http://dx.doi.org/10.4193/Rhin19.466DOI Listing

Estrogen receptor α activation aggravates imiquimod-induced psoriasis-like dermatitis in mice by enhancing dendritic cell interleukin-23 secretion.

J Appl Toxicol 2020 May 5. Epub 2020 May 5.

Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara-shi, Kanagawa, Japan.

Our recent study has reported that estrogen receptors (ERs) are involved in several types of allergy development. This study aims to investigate the possible relationship between ER activation and development of imiquimod-induced psoriasis-like dermatitis. A mouse model of imiquimod-induced psoriasis-like dermatitis was generated by 5 days of topical application of 5% of imiquimod cream on the back of the ear and the shaved back skin of male BALB/c mice. Read More

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http://dx.doi.org/10.1002/jat.3988DOI Listing

Retinopathy of prematurity treatment in the UK: trends in neonatal anaesthetic support and location of treatment from a national surveillance study.

Eur J Pediatr 2020 May 4. Epub 2020 May 4.

Ophthalmology Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

The aim of this study is to evaluate current anaesthetic practice for retinopathy of prematurity (ROP) interventions in the UK. We collected the data from the 12-month prospective British Ophthalmic Surveillance Unit study carried out in 2013/2014 that were analysed with regard to type of anaesthesia used for primary ROP procedures and the hospital department in which treatment took place. A total of 327 cases of treated ROP from 55 different UK units were reported in the study. Read More

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http://dx.doi.org/10.1007/s00431-020-03650-3DOI Listing

Combined aspirin and clopidogrel therapy in phacoemulsification cataract surgery: a risk factor for ocular hemorrhage?

Int Ophthalmol 2020 Apr 27. Epub 2020 Apr 27.

Department of Ophthalmology, Huashan Hospital, Fudan University, No. 12 Middle Urumqi Road, Shanghai, 200040, China.

Purpose: To evaluate the safety of phacoemulsification cataract surgery in the patients undergoing dual antiplatelet therapy with aspirin and clopidogrel.

Methods: Consecutive patients undergoing phacoemulsification cataract surgery with a clear corneal incision under topical anesthesia were eligible for inclusion in the study. Thirty-eight eyes from 38 patients on combined aspirin and clopidogrel therapy who continued the treatment were classified into the maintenance group, a matched group of 38 eyes from 38 patients on no antiplatelet/anticoagulant therapy as the control group. Read More

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http://dx.doi.org/10.1007/s10792-020-01378-5DOI Listing

A comparison of three different tonometric methods in the measurement of intraocular pressure in the pediatric age group.

Int Ophthalmol 2020 Apr 23. Epub 2020 Apr 23.

Fethi Sekin City Hospital, Ophthalmology Clinic, University of Health Sciences, Elazig, Turkey.

Introduction And Aim: To compare intraocular pressure (IOP) measurements obtained with non-contact tonometry (NCT), Icare rebound tonometry (IRT) and Goldmann applanation tonometry (GAT) in pediatric cases and to examine the effect of topical anesthesia on measurements obtained using IRT.

Materials And Methods: Pediatric cases in a healthy general condition and with ophthalmic examination findings within normal limits were included in the study. IOP measurements were taken with NCT and IRT devices in all cases. Read More

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http://dx.doi.org/10.1007/s10792-020-01375-8DOI Listing

Intraoperative aberrometry in cataract surgery with topical versus peribulbar anesthesia.

Indian J Ophthalmol 2020 May;68(5):776-779

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Delhi, India.

Purpose: To study the effect of choice of anesthesia on the refractive outcomes of intraoperative aberrometry (IA) for intraocular lens power calculation in cataract surgeries.

Methods: This prospective, interventional nonrandomized cohort study was conducted at a tertiary care hospital between March and August 2018. A total of 178 patients with age-related cataract were allocated into two groups. Read More

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http://dx.doi.org/10.4103/ijo.IJO_913_19DOI Listing

Cataract Surgery in Patients with Left Ventricular Assist Devices.

J Cataract Refract Surg 2020 Apr 16. Epub 2020 Apr 16.

From the Department of Ophthalmology, Duke University, Durham, North Carolina, USA.

Purpose: To determine the safety and efficacy of cataract surgery in patients with left ventricular assist devices (LVADs).

Setting: Duke Eye Center, Durham, NC, USA.

Design: Retrospective case series. Read More

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http://dx.doi.org/10.1097/j.jcrs.0000000000000216DOI Listing

Reducing pain and distress related to needle procedures in children with cancer: A clinical practice guideline.

Eur J Cancer 2020 May 14;131:53-67. Epub 2020 Apr 14.

University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Oncology/Hematology, Groningen, the Netherlands; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

Background: Children with cancer often undergo long treatment trajectories involving repeated needle procedures that potentially cause pain and distress. As part of a comprehensive effort to develop clinical practice guidelines (CPGs) to address pain prevention and management in children with cancer, we aimed to provide recommendations on the pharmacological and psychological management of procedure-related pain and distress.

Methods: Of the international inter-disciplinary CPG development panel (44 individuals), two working groups including 13 healthcare professionals focused on procedural pain and distress. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.02.039DOI Listing

Efficacy of lidocaine 7 %, tetracaine 7 % self-occlusive cream in reducing MAL-cPDT-associated pain in subjects with actinic keratosis: A randomized, single-blind, vehicle-controlled trial (The "3P-Trial").

Photodiagnosis Photodyn Ther 2020 Jun 12;30:101758. Epub 2020 Apr 12.

Dermatology Medica Plus, Modena, Italy.

Introduction: Conventional photodynamic therapy (cPDT) is considered a very effective treatment of actinic keratosis (AK) lesions. However, its use is limited by the fact that this procedure could be very painful. The use of topical anesthetics such as tetracaine or lignocaine/prilocaine has shown disappointing results in term of pain reduction. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101758DOI Listing
June 2020
2.014 Impact Factor