5,290 results match your criteria Anemia of Chronic Disease and Renal Failure


Comorbidity burden and revascularization benefit in elderly patients with acute coronary syndrome.

Rev Esp Cardiol (Engl Ed) 2020 Aug 7. Epub 2020 Aug 7.

Servicio de Cardiología, Hospital Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Introduction And Objectives: To evaluate the interaction between comorbidity burden and the benefits of in-hospital revascularization in elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS).

Methods: This retrospective study included 7211 patients aged ≥ 70 years from 11 Spanish NSTEACS registries. Six comorbidities were evaluated: diabetes, peripheral artery disease, cerebrovascular disease, chronic pulmonary disease, renal failure, and anemia. Read More

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http://dx.doi.org/10.1016/j.rec.2020.06.015DOI Listing

Iatrogenic Iron Overload in an End Stage Renal Disease Patient.

Case Rep Oncol 2020 May-Aug;13(2):760-763. Epub 2020 Jun 30.

Department of Medical Oncology, National Center for Cancer Care and Research, Doha, Qatar.

Iron overload is a common complication in patients with chronic renal failure treated with dialysis prior to the availability of recombinant human erythropoietin therapy. Iron overload was the result of hypoproliferative erythroid marrow function coupled with the need for frequent red blood cell transfusions to manage symptomatic anemia. The repetitive use of intravenous iron with or without the use of red blood cell transfusions also contributed to iron loading and was associated with iron deposition in liver parenchymal and reticuloendothelial cells. Read More

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http://dx.doi.org/10.1159/000507979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383200PMC

Current and Emerging Drugs in the Treatment of Anemia in Patients with Chronic Kidney Disease.

J Pharm Pharm Sci 2020 ;23:278-288

Department of Nephrology, the Second Affiliated Hospital, Shantou University Medical College, 515041, Shantou, China.

Anemia is a common complication of chronic kidney disease (CKD), and its prevalence has shown a tendency to increase in many countries. Anemia is associated with incident heart failure and increases mortality in CKD patients, garnering public attention. Here, we reviewed recent studies about CKD with anemia, and tried to summarize the risks and causes and new progress in the treatment of renal anemia. Read More

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http://dx.doi.org/10.18433/jpps30919DOI Listing
January 2020

Ambient air pollution and cause-specific risk of hospital admission in China: A nationwide time-series study.

PLoS Med 2020 Aug 6;17(8):e1003188. Epub 2020 Aug 6.

Center for Big Data Research in Health and Medicine, Institute for Data Sciences, Tsinghua University, Beijing, China.

Background: The impacts of air pollution on circulatory and respiratory systems have been extensively studied. However, the associations between air pollution exposure and the risk of noncommunicable diseases of other organ systems, including diseases of the digestive, musculoskeletal, and genitourinary systems, remain unclear or inconclusive. We aimed to systematically assess the associations between short-term exposure to main air pollutants (fine particulate matter [PM2. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003188DOI Listing

Sex-related differences in chronic heart failure: a community-based study.

J Cardiovasc Med (Hagerstown) 2020 Jul 17. Epub 2020 Jul 17.

Cardiothoracicvascular Department, Cardiovascular Center, University Hospital and Health Services, Trieste.

Background: An important knowledge gap remains about sex-related differences in the heart failure setting.

Objectives: To evaluate sex-related differences among real-life outpatients with chronic heart failure across the ejection fraction spectrum and to evaluate whether these differences might impact therapy and outcomes.

Methods And Results: A total of 2528 heart failure patients were examined between 2009 and 2015 [mean age 76, 42% females; 59% with heart failure with preserved ejection fraction (HFpEF), 17% with heart failure with mid-range ejection fraction (HFmrEF) and 24% with heart failure with reduced ejection fraction (HFrEF)]. Read More

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http://dx.doi.org/10.2459/JCM.0000000000001049DOI Listing

Coagulation Status and Venous Thromboembolism Risk in African Americans: A Potential Risk Factor in COVID-19.

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029620943671

Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is known to induce severe inflammation and activation of the coagulation system, resulting in a prothrombotic state. Although inflammatory conditions and organ-specific diseases have been shown to be strong determinants of morbidity and mortality in patients with COVID-19, it is unclear whether preexisting differences in coagulation impact the severity of COVID-19. African Americans have higher rates of COVID-19 infection and disease-related morbidity and mortality. Read More

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http://dx.doi.org/10.1177/1076029620943671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383642PMC

Quality of life of chronic kidney patients on hemodialysis and related factors.

Rev Lat Am Enfermagem 2020 15;28:e3327. Epub 2020 Jul 15.

Departamento de Ciências da Vida, Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Ijui, RS, Brazil.

Objective: to verify the association between the health-related quality of life of chronic renal patients on hemodialysis with sociodemographic, clinical, depression and medication adherence characteristics.

Method: a cross-sectional study with 183 chronic renal patients undergoing hemodialysis in the state of Rio Grande do Sul, Brazil. A sociodemographic and clinical questionnaire, Kidney Disease and Quality of Life Short-Form, Beck Depression Inventory and Morisky Medication Adherence Scale - eight items were used. Read More

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http://dx.doi.org/10.1590/1518-8345.3641.3327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365615PMC

Heart failure with preserved ejection fraction in Belgium: characteristics and outcome of a real-life cohort.

Acta Cardiol 2020 Jul 17:1-10. Epub 2020 Jul 17.

Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc and Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium.

Background: Due to aging of the population and the increase of cardiovascular risk factors, heart failure and preserved ejection fraction (HFpEF) is a rising health issue. Few data exist on the phenotype of HFpEF patients in Belgium and on their prognosis.

Objectives: We describe clinical characteristics and outcomes of Belgian HFpEF patients. Read More

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http://dx.doi.org/10.1080/00015385.2020.1770460DOI Listing

Antibody-mediated pure red cell aplasia related with epoetin-beta pegol (C.E.R.A.) as an erythropoietic agent: case report of a dialysis patient.

BMC Nephrol 2020 Jul 14;21(1):275. Epub 2020 Jul 14.

Department of Nephrology, Kyoto Yamashiro General Medical Center, 1-27 Kizuekimae, Kizugawa, Kyoto, 619-0214, Japan.

Background: Erythropoietin-stimulating agents (ESAs) are used to treat anemia in patients with chronic kidney disease, enabling maintenance of stable hemoglobin levels and eliminating the need for multiple transfusions. Epoetin-beta pegol (C.E. Read More

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http://dx.doi.org/10.1186/s12882-020-01934-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362491PMC

Outcome of peripheral blood allogeneic hematopoietic stem cell transplantation as a treatment option in patients with severe aplastic anemia between 40 and 50 years.

Hematol Oncol Stem Cell Ther 2020 Jul 3. Epub 2020 Jul 3.

Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

The frontline treatment for patients younger than 40 years with severe aplastic anemia (AA) is allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-identical sibling donor. However, in patients with severe AA who are older than 40 years, allogeneic HSCT has been found to be associated with increased treatment-related mortality and toxicity, even when matched sibling donors are used. We report our institutional experience with allogeneic HSCT in patients with severe AA between 40 and 50 years. Read More

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http://dx.doi.org/10.1016/j.hemonc.2020.06.004DOI Listing

Comorbid disease drives short-term hospitalization outcomes in patients with multiple sclerosis.

Neurol Clin Pract 2020 Jun;10(3):255-264

Department of Neurology (AM, DPT, JAC, AP, AWW), University of Pennsylvania Perelman School of Medicine; Department of Neurology Translational Center of Excellence for Neuroepidemiology (DPT, JAC, AWW), Neurological Outcomes and Disparities Research, University of Pennsylvania Perelman School of Medicine; Department of Biostatistics (AWW), Epidemiology and Informatics, University of Pennsylvania; Center for Clinical Epidemiology and Biostatistics (AWW), University of Pennsylvania Perelman School of Medicine; and Leonard Davis Institute of Health Economics (AWW), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Objective: Readmission is used as a quality indicator and is the primary target outcome for disease-modifying therapy (DMT) for multiple sclerosis (MS). However, data on readmissions for patients with MS are limited.

Methods: Using the US Nationwide Readmissions Database, we performed a retrospective cohort study of adults hospitalized for MS in 2014. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292556PMC

Trends of Clinical Outcomes and Health Care Resource Use in Heart Failure in the United States.

J Am Heart Assoc 2020 Jul 4;9(14):e016782. Epub 2020 Jul 4.

Department of Cardiovascular Medicine Mayo Clinic Rochester MN.

Background Heart failure (HF) imparts a significant clinical and economic burden on the health system in the United States. Methods and Results We used the National Inpatient Sample database between September 2002 and December 2016. We examined trends of comorbidities, inpatient mortality, and healthcare resource use in patients admitted with acute HF. Read More

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http://dx.doi.org/10.1161/JAHA.120.016782DOI Listing

Roxadustat for Anemia in Patients with Chronic Kidney Disease. Reply.

Authors:
Joshua M Kaplan

N Engl J Med 2020 07;383(1):e3

Rutgers-New Jersey Medical School, Newark, NJ

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http://dx.doi.org/10.1056/NEJMc1913712DOI Listing

Roxadustat for Anemia in Patients with Chronic Kidney Disease. Reply.

N Engl J Med 2020 07;383(1):e3

Ruijin Hospital, Shanghai, China

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http://dx.doi.org/10.1056/NEJMc1913712DOI Listing

Roxadustat for Anemia in Patients with Chronic Kidney Disease.

N Engl J Med 2020 07;383(1):e3

Donald and Barbara Zucker School of Medicine at Hofstra-Northwell, Great Neck, NY

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http://dx.doi.org/10.1056/NEJMc1913712DOI Listing

Roxadustat for Anemia in Patients with Chronic Kidney Disease.

N Engl J Med 2020 07;383(1):e3

University of Florida, Gainesville, FL

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http://dx.doi.org/10.1056/NEJMc1913712DOI Listing

Roxadustat for Anemia in Patients with Chronic Kidney Disease.

N Engl J Med 2020 07;383(1):e3

Medical University of Warsaw, Warsaw, Poland

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http://dx.doi.org/10.1056/NEJMc1913712DOI Listing

Roxadustat for Anemia in Patients with Chronic Kidney Disease.

N Engl J Med 2020 07;383(1):e3

Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.

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http://dx.doi.org/10.1056/NEJMc1913712DOI Listing

Reasons for readmission after hospital discharge in patients with chronic diseases-Information from an international dataset.

PLoS One 2020 30;15(6):e0233457. Epub 2020 Jun 30.

Dr Foster Telstra Health, London, United Kingdom.

Background: Chronic diseases are increasingly prevalent in Western countries. Once hospitalised, the chance for another hospitalisation increases sharply with large impact on well-being of patients and costs. The pattern of readmissions is very complex, but poorly understood for multiple chronic diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233457PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326238PMC

Incidence and risk factors of in-hospital prosthesis-related complications following total hip arthroplasty: a retrospective Nationwide Inpatient Sample database study.

Int Orthop 2020 Jun 27. Epub 2020 Jun 27.

Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue, Guangzhou, 510515, Guangdong, China.

Purpose: The occurrence of prosthesis-related complications (PRCs) after total hip arthroplasty (THA) is devastating, commonly meaning implant failure and revision surgery. The purpose was to examine the incidence and risk factors of in-hospital PRCs following THA using a large-scale national database.

Methods: A retrospective database analysis was performed based on Nationwide Inpatient Sample (NIS) from 2005 to 2014. Read More

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http://dx.doi.org/10.1007/s00264-020-04682-yDOI Listing

Central Role for Adipocyte Na,K-ATPase Oxidant Amplification Loop in the Pathogenesis of Experimental Uremic Cardiomyopathy.

J Am Soc Nephrol 2020 Aug 25;31(8):1746-1760. Epub 2020 Jun 25.

Departments of Medicine, Surgery, and Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia

Background: Oxidative stress in adipocyte plays a central role in the pathogenesis of obesity as well as in the associated cardiovascular complications. The putative uremic toxin indoxyl sulfate induces oxidative stress and dramatically alters adipocyte phenotype . Mice that have undergone partial nephrectomy serve as an experimental model of uremic cardiomyopathy. Read More

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http://dx.doi.org/10.1681/ASN.2019101070DOI Listing

Safety and Efficacy of Methoxy Polyethylene Glycol-epoetin Beta in Anemia Treatment in Patients on Hemodialysis: a Macedonian Experience.

Med Arch 2020 Apr;74(2):109-114

Institute of Social Medicine, Faculty of Medicine, Skopje, North Macedonia.

Introduction: Anemia in patients with chronic kidney disease (CKD) is present in about 50% in pre-dialysis and over 90% of patients on hemodialysis. Erythropoiesis-stimulating agent (ESA) is a standard therapy for renal anemia, but management of anemia in CKD still remains a challenge from the treatment point of view.

Aim: To evaluate safety and efficacy of methoxy polyethylene glycol-epoetin beta as continuous erythropoietin receptor activator (C. Read More

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http://dx.doi.org/10.5455/medarh.2020.74.109-114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296413PMC

Characteristics of patients at initiation of renal replacement therapy - experience of a hemodialysis center.

Exp Ther Med 2020 Jul 17;20(1):103-108. Epub 2020 Mar 17.

Discipline of Internal Medicine I and Nephrology, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

The monitoring and care of patients with chronic kidney disease (CKD) before the dialysis initiation contribute to a better survival rate and an improvement in quality of life. The patients who do not benefit from a good predialysis management have a worse short and long-term prognosis. A retrospective, unicentric study was performed to evaluate the status of patients with stage 5 CKD at the time of initiation of renal replacement treatment. Read More

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http://dx.doi.org/10.3892/etm.2020.8608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271700PMC
July 2020
0.941 Impact Factor

Successful sirolimus therapy of an aplastic anemia patient with chronic kidney disease: A case report.

Medicine (Baltimore) 2020 Jun;99(23):e20669

Department of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.

Rationale: It is very difficult to treat patients with aplastic anemia accompanied by chronic kidney disease. The nephrotoxicity of cyclosporine limits its use in these patients. Most of these patients also lack suitable sibling donors. Read More

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http://dx.doi.org/10.1097/MD.0000000000020669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306392PMC

[Therapeutic innovation in nephrology : 10 years of progress].

Rev Med Liege 2020 May;75(5-6):336-343

Service de Néphrologie-Dialyse-Transplantation, CHU Liège, Belgique.

Chronic kidney disease (CKD) impairs the quality of life and increases the risk for cardiovascular morbimortality. Intensive research is conducted in order to slow down CKD development and progression. During the past decade, a better understanding of the pathophysiological mechanisms of glomerular diseases has highlighted the benefits of rituximab. Read More

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Low Serum Bicarbonate and CKD Progression in Children.

Clin J Am Soc Nephrol 2020 Jun 28;15(6):755-765. Epub 2020 May 28.

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.

Background And Objectives: Studies of adults have demonstrated an association between metabolic acidosis, as measured by low serum bicarbonate levels, and CKD progression. We evaluated this relationship in children using data from the Chronic Kidney Disease in Children study.

Design, Setting, Participants, & Measurements: The relationship between serum bicarbonate and a composite end point, defined as 50% decline in eGFR or KRT, was described using parametric and semiparametric survival methods. Read More

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http://dx.doi.org/10.2215/CJN.07060619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274283PMC

Managing breakthrough pain for advanced malignancy in elderly patients: A real challenge.

J Opioid Manag 2020 May/Jun;16(3):219-222

Additional Professor, Department of Onco-Anaesthesia and Palliative medicine, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India.

Pain management in advanced cancer patients using opioids like morphine is challenging due to presence of predisposing factors like renal insufficiency, hepatic insufficiency, hypoproteinemia, hypoalbuminemia, and anemia that can easily precipitate inadvertent toxic effects. We report a case morphine toxicity in an elderly patient of lung cancer with concomitant presence of chronic obstructive pulmonary disease (COPD) and recent onset renal impairment. Opioid analgesic overdose is a lethal but at the same time, a preventable and treatable condition. Read More

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http://dx.doi.org/10.5055/jom.2020.0571DOI Listing

Polycythemia and Anemia in Hereditary Hemochromatosis.

Cureus 2020 Apr 9;12(4):e7607. Epub 2020 Apr 9.

Gastroenterology and Hepatology, West Virginia University School of Medicine, Morgantown, USA.

Introduction Hereditary hemochromatosis is a syndrome of dysregulated iron homeostasis resulting in the excessive deposition of iron. Hemochromatosis causes pulmonary, pancreatic, and hepatic dysfunction, all of which are risk factors for anemia in the general population. Conversely, iron overload states are thought to predispose to polycythemia. Read More

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http://dx.doi.org/10.7759/cureus.7607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213665PMC

Sacubitril-Valsartan Improves Anemia Of Cardiorenal Syndrome.

Cardiovasc Hematol Agents Med Chem 2020 May 5. Epub 2020 May 5.

Department of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura. Spain.

Background And Aims: Anemia is a common complication of heart failure and chronic kidney disease (CKD). Sacubitril-valsartan is a novel therapy for the treatment of chronic heart failure with a reduced ejection fraction (HFrEF). We have evaluated the short-term effects of sacubitril-valsartan on the anemia of CRS. Read More

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http://dx.doi.org/10.2174/1871525718666200506095537DOI Listing

[Prevalence of Advanced Chronic Kidney Disease in Patients with Nonvalvular Atrial Fibrillation Hospitalized in Cardiology Departments].

Kardiologiia 2020 Mar 5;60(2):41-46. Epub 2020 Mar 5.

First Sechenov Moscow State Medical University under Ministry of Health, Moscow.

Objective: To estimate the prevalence of chronic kidney disease (CKD) 3b - 5 stages and the newly diagnosed sustained reduction in glomerular filtration rate (GFR) <30 ml / min / 1.73 m2 in patients with atrial fibrillation (AF) in real clinical practice, as well as the features of their anticoagulant therapy.

Materials And Methods:  Retrospectively, data of all discharge epicrisis from cardiological departments of five Moscow hospitals from June 1, 2016 to May 31, 2017 were analyzed. Read More

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http://dx.doi.org/10.18087/cardio.2020.2.n823DOI Listing

The validity of reticulocyte hemoglobin content and percentage of hypochromic red blood cells for screening iron-deficiency anemia among patients with end-stage renal disease: a retrospective analysis.

BMC Nephrol 2020 Apr 22;21(1):142. Epub 2020 Apr 22.

Department of Hematology Laboratory, Cho Ray Hospital, Ho Chi Minh City, Vietnam.

Background: Early detection of iron-deficiency anemia (IDA) can enhance the efficiency and effectiveness of clinical treatment and quality of life for end-stage renal disease (ESRD) patients. This study aimed to evaluate the validity of CHr and %Hypo in screening IDA among ESRD patients and compare their performance with screening IDA among non-ESRD patients.

Method: A retrospective analysis of 312 participants was conducted at Cho Ray Hospital, Vietnam, including healthy control participants and ESRD patients. Read More

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http://dx.doi.org/10.1186/s12882-020-01796-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178621PMC

The problem with transferrin saturation as an indicator of iron 'sufficiency' in chronic kidney disease.

Nephrol Dial Transplant 2020 Apr 17. Epub 2020 Apr 17.

INSERM U1018, Team 5, CESP, Paris Saclay University, Paris-Sud Univ, UVSQ, Villejuif, France.

After a brief review of physiological iron metabolism, we describe diagnostic tests for iron status and iron deficiency anemia in patients without chronic kidney disease (CKD) or inflammation. Thereafter we review the dysregulation of iron metabolism in CKD. Specific emphasis is placed on the role of the 'inflammatory' state that develops with the progression of CKD. Read More

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http://dx.doi.org/10.1093/ndt/gfaa048DOI Listing

[Specificity of anemic syndrome in geriatric patients with chronic kidney disease.]

Klin Lab Diagn 2020 ;65(5):275-280

Samara State Medical University, 443099, Samara, Russia.

Anemic syndrome is detected in 10-25% of geriatric patients, and with increasing age, there is a tendency to increase the incidence of the disease. Among the diseases that lead to the development of anemia, kidney pathology plays an important role. Progressive deterioration of kidney function in old age is associated with an increased risk of fractures, sarcopenia, and the development of cognitive impairment. Read More

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http://dx.doi.org/10.18821/0869-2084-2020-65-5-275-280DOI Listing

Iron Sucrose: A Wealth of Experience in Treating Iron Deficiency.

Adv Ther 2020 05 15;37(5):1960-2002. Epub 2020 Apr 15.

Department of Gastroenterology, University Hospital Heraklion, Crete, Greece.

Iron deficiency and iron-deficiency anemia are associated with increased morbidity and mortality in a wide range of conditions. In many patient populations, this can be treated effectively with oral iron supplementation; but in patients who are unable to take or who do not respond to oral iron therapy, intravenous iron administration is recommended. Furthermore, in certain conditions, such as end-stage kidney disease, chronic heart failure, and inflammatory bowel disease, intravenous iron administration has become first-line treatment. Read More

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http://dx.doi.org/10.1007/s12325-020-01323-zDOI Listing

HEPATITIS C TREATMENT OF RENAL TRANSPLANT AND CHRONIC KIDNEY DISEASE PATIENTS: EFFICACY AND SAFETY OF DIRECT-ACTING ANTIVIRAL REGIMENS CONTAINING SOFOSBUVIR.

Arq Gastroenterol 2020 Jan-Mar;57(1):45-49

Universidade Federal de São Paulo (UNIFESP), Disciplina de Gastroenterologia, São Paulo, SP, Brasil.

Background: Direct-acting antivirals have revolutionized hepatitis C treatment, also for patients with chronic kidney disease (CKD), but some controversy exists regarding the use of sofosbuvir (SOF) in patients with glomerular filtration rate (GFR) <30 mL/min.

Objective: To evaluate the efficacy and safety of these regimens for hepatitis C treatment of patients with CKD and after renal transplantation, as well as the impact of SOF on renal function in non-dialysis patients.

Methods: All patients with hepatitis C and CKD or renal transplant treated with direct-acting antivirals at a referral center in Brazil between January 2016 and August 2017 were included. Read More

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http://dx.doi.org/10.1590/S0004-2803.202000000-09DOI Listing

Darbepoetin Alfa in Patients with Advanced CKD without Diabetes: Randomized, Controlled Trial.

Clin J Am Soc Nephrol 2020 May 3;15(5):608-615. Epub 2020 Apr 3.

Division of Nephrology, Showa University School of Medicine, Tokyo, Japan.

Background And Objectives: Large, randomized, controlled trials targeting higher hemoglobin level with erythropoiesis-stimulating agents for Western patients with CKD showed harm. However, the effect of anemia correction using erythropoiesis-stimulating agents may differ between CKD subpopulations. The Prevention of ESKD by Darbepoetin Alfa in CKD Patients with Non-diabetic Kidney Disease study, a multicenter, randomized, open-label, parallel-group study, aimed to examine the effect of targeting hemoglobin levels of 11-13 g/dl using darbepoetin alfa with reference to a low-hemoglobin target of 9-11 g/dl on kidney outcome in patients with advanced CKD without diabetes in Japan. Read More

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http://dx.doi.org/10.2215/CJN.08900719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269223PMC

Prevalence of anemia in predialysis chronic kidney disease: Is the study center a significant factor?

PLoS One 2020 2;15(4):e0230980. Epub 2020 Apr 2.

Department of Nephrology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Objectives: Anemia is highly prevalent in chronic kidney disease patients; however, its identification and management have been reported to be suboptimal. In this study we aimed to describe the prevalence, severity, risk factors, and treatment of anemia in different nephrology centers, among chronic kidney disease patients who were not given renal replacement therapy.

Materials And Methods: We performed a multicenter cross-sectional study in three different nephrology clinics. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230980PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117725PMC

Evaluation of serum neutrophil gelatinase-associated lipocalin in older patients with chronic kidney disease.

Aging Med (Milton) 2020 Mar 27;3(1):32-39. Epub 2020 Mar 27.

Division of Nephrology Department of Geriatrics The First Affiliated Hospital with Nanjing Medical University Nanjing China.

Objective: Chronic kidney disease (CKD) is a major health-care burden all over the world, and aging is an important risk factor for end-stage renal disease (ESRD). Neutrophil gelatinase-associated lipocalin (NGAL) has been confirmed as a novel marker for early diagnosis of acute kidney injury. Other studies have found that NGAL takes part in the mechanisms of CKD progression. Read More

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http://dx.doi.org/10.1002/agm2.12098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099757PMC

Intravenous iron: a framework for changing the management of iron deficiency.

Lancet Haematol 2020 Apr;7(4):e342-e350

Department of Renal Medicine, King's College Hospital, London, UK.

For decades intravenous iron was considered dangerous. Newer formulations with carbohydrate cores binding elemental iron more tightly allow complete iron replacement within 15-60 min in one visit. Meta-analyses and prospective comparisons of different formulations support equivalent safety to placebo with less toxicity than oral iron. Read More

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http://dx.doi.org/10.1016/S2352-3026(19)30264-9DOI Listing

The burden of non-cardiac comorbidities and association with clinical outcomes in an acute heart failure trial - insights from ASCEND-HF.

Eur J Heart Fail 2020 Jun 25;22(6):1022-1031. Epub 2020 Mar 25.

Division of Cardiology, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC, USA.

Aims: Non-cardiac comorbidities are highly prevalent in patients with heart failure (HF). Our objective was to define the association between non-cardiac comorbidity burden and clinical outcomes, costs of care, and length of stay within a large randomized trial of acute HF patients.

Methods And Results: Patients with complete medical history for the following comorbidities were included: diabetes mellitus, chronic obstructive pulmonary disease, chronic liver disease, history of cancer within the last 5 years, chronic renal disease (baseline serum creatinine >3. Read More

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http://dx.doi.org/10.1002/ejhf.1795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394726PMC

Identification of Risk Factors for Readmission in Patients Undergoing Anterior Cervical Discectomy Fusion: A Predictive Risk Scale.

Clin Spine Surg 2020 Mar 20. Epub 2020 Mar 20.

Department of Orthopaedics, Rutgers-New Jersey Medical School, Newark, NJ.

Study Design: This was a retrospective cohort study.

Objective: The objective of this study was to analyze readmission rates among patients undergoing anterior cervical discectomy and fusion (ACDF), determine which factors were associated with higher readmission rates, and develop a scale for utilization during surgical planning.

Summary Of Background Data: ACDF is the most common surgical treatment for many cervical disk pathologies. Read More

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http://dx.doi.org/10.1097/BSD.0000000000000962DOI Listing

Bi-allelic mutations in renin-angiotensin system genes, associated with renal tubular dysgenesis, can also present as a progressive chronic kidney disease.

Pediatr Nephrol 2020 06 20;35(6):1125-1128. Epub 2020 Mar 20.

APHP, Néphrologie pédiatrique, Centre de Référence MARHEA, Hôpital Universitaire Necker-Enfants malades, 149 rue de Sèvres, 75015, Paris, France.

Background: Bi-allelic loss of function variations in genes encoding proteins of the renin-angiotensin system (AGT, ACE, REN, AGTR1) are associated with autosomal recessive renal tubular dysgenesis, a severe disease characterized by the absence of differentiated proximal tubules leading to fetal anuria and neonatal end-stage renal disease.

Case-diagnosis/treatment: We identified bi-allelic loss of function mutations in ACE, the gene encoding angiotensin-converting enzyme, in 3 unrelated cases displaying progressive chronic renal failure, whose DNAs had been sent for suspicion of juvenile hyperuricemic nephropathy, nephronophthisis, and cystic renal disease, respectively. In all cases, patients were affected with anemia whose severity was unexpected regarding the level of renal failure and with important polyuro-polydipsia. Read More

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http://dx.doi.org/10.1007/s00467-020-04524-4DOI Listing

Association Between Subsequent Hospitalizations and Recurrent Acute Myocardial Infarction Within 1 Year After Acute Myocardial Infarction.

J Am Heart Assoc 2020 Mar 14;9(6):e014907. Epub 2020 Mar 14.

Center for Outcomes Research and Evaluation Yale-New Haven Hospital New Haven CT.

Background Patients who survive acute myocardial infarction (AMI) are at high risk for recurrence. We determined whether rehospitalizations after AMI further increased risk of recurrent AMI. Methods and Results The study included Medicare fee-for-service patients aged ≥65 years discharged alive after AMI from acute-care hospitals in fiscal years 2009-2014. Read More

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http://dx.doi.org/10.1161/JAHA.119.014907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335517PMC

Cardiac Remodeling in Chronic Kidney Disease.

Toxins (Basel) 2020 03 5;12(3). Epub 2020 Mar 5.

Clinic for Renal and Hypertensive Disorders, Rheumatological and Immunological Disease, University Hospital of the RWTH Aachen, 52074 Aachen, Germany.

Cardiac remodeling occurs frequently in chronic kidney disease patients and affects quality of life and survival. Current treatment options are highly inadequate. As kidney function declines, numerous metabolic pathways are disturbed. Read More

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http://dx.doi.org/10.3390/toxins12030161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150902PMC

Elixhauser comorbidity measures-based risk factors associated with 30-day mortality in elderly population after femur fracture surgery: a propensity scorematched retrospective case-control study.

Acute Crit Care 2020 Feb 29;35(1):10-15. Epub 2020 Feb 29.

Department of Anesthesiology and Pain Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

Background: As the average life expectancy increases, anesthesiologists confront unique challenges in the perioperative care of elderly patients who have significant comorbidities. In this study, we evaluated Elixhauser comorbidity measures-based risk factors associated with 30day mortality in patients aged 66 years and older who underwent femur fracture surgery.

Methods: We used the Medical Information Mart for Intensive Care III which contains the medical records of patients admitted to the intensive care unit (ICU) at Beth Israel Deaconess Medical Center in the United States between 2001 and 2012 to identify patients admitted to the ICU after femur fracture surgery (n=209). Read More

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http://dx.doi.org/10.4266/acc.2019.00745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056954PMC
February 2020

A Rare Case of Simultaneous Evans Syndrome and Primary Antiphospholipid Syndrome.

Cureus 2020 Feb 1;12(2):e6845. Epub 2020 Feb 1.

Hematology/Oncology, Summa Akron City Hospital, Summa Health System, Akron, USA.

Evans Syndrome (ES) is a rare autoimmune disorder that presents with simultaneous or sequential development of autoimmune hemolytic anemia (AIHA), thrombocytopenia, and/or neutropenia. This disease may occur in conjunction with other autoimmune disorders. Primary antiphospholipid syndrome (APS) is a disorder characterized by thrombosis, which can cause life-threatening complications such as fetal demise, strokes, or deep vein thrombosis. Read More

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http://dx.doi.org/10.7759/cureus.6845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053248PMC
February 2020

Intractable mechanical hemolytic anemia complicating mitral valve surgery: a case series study.

BMC Cardiovasc Disord 2020 03 3;20(1):104. Epub 2020 Mar 3.

Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 100730, No.1 Shuaifu Yuan, Dongcheng District, Beijing, China.

Background: Intractable, mechanical hemolytic anemia (IMHA) is a rare catastrophic complication following mitral valve surgery. We analyzed patient characteristics and IMHA management by reoperations after mitral valve surgery.

Methods: We collected medical records from mitral valve patients requiring reoperation due to IMHA. Read More

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http://dx.doi.org/10.1186/s12872-020-01382-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055100PMC

Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia.

Intern Med 2020 1;59(5):683-687. Epub 2020 Mar 1.

Department of Nephrology and Rheumatology, Aichi Medical University, Japan.

A 45-year-old man with idiopathic aplastic anemia required renal replacement therapy (RRT) due to end-stage renal disease (ESRD). We succeeded in inserting the peritoneal dialysis (PD) catheter under cover of frequent red blood cell and platelet infusions because of severe pancytopenia. During the one-year period after starting PD using an ultraviolet-ray sterilization device, he developed severe leukopenia but no PD-related peritonitis or exit site/tunnel infection until he died of pneumonia. Read More

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http://dx.doi.org/10.2169/internalmedicine.3775-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086332PMC

SPTB related spherocytosis in a three-generation family presenting with kidney failure in adulthood due to co-occurrence of UMOD disease causing variant.

Nefrologia 2020 Feb 26. Epub 2020 Feb 26.

University Medical Centre Ljubljana, University Children's Hospital, Institute for Special Laboratory Diagnostics, Ljubljana, Slovenia; University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Ljubljana, Slovenia. Electronic address:

Background: Hereditary spherocytosis is clinically and genetically heterogeneous disorder and its clinical characteristics are spherocytosis, anaemia, jaundice and splenomegaly. The aetiology is associated to the genes encoding proteins involved in the interaction between the erythrocyte membrane and the lipid bilayer. Causative variants in βI-spectrin (SPTB) gene presenting as mild to moderately severe disease are responsible for approximately 25% cases in the USA and Europe. Read More

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http://dx.doi.org/10.1016/j.nefro.2019.10.009DOI Listing
February 2020

[Cor pulmonale].

Rev Mal Respir 2020 Mar 19;37(3):257-266. Epub 2020 Feb 19.

Réanimation médico-chirurgicale, pôle thorax-vaisseaux-abdomen-métabolisme, hôpital universitaire Ambroise-Paré, Assistance publique-Hôpitaux de Paris, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France; Faculté de médecine Paris Île-de-France Ouest, université de Versailles-Saint-Quentin-en-Yvelines, 78280 Saint-Quentin-en-Yvelines, France; INSERM U-1018, CESP, Team 5 (EpReC, Renal and Cardiovascular Epidemiology), UVSQ, 94807 Villejuif, France. Electronic address:

Cor pulmonale is a disease of the heart characterised by dilatation of the right ventricle and paradoxical movement of the interventricular septum. The diagnosis depends on echocardiography even if pulmonary artery catheterisation suggests it. It is secondary to pulmonary disease or a disorder of the pulmonary circulation. Read More

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http://dx.doi.org/10.1016/j.rmr.2019.10.012DOI Listing