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ESMO Open 2021 Jul 27;6(4):100212. Epub 2021 Jul 27.

Department of Medical Oncology Department, Clínica Universidad de Navarra, Madrid, Spain.

Background: There is limited evidence for the benefit of olaparib in platinum-resistant ovarian cancer (PROC) patients with BRCA wild-type tumors. This study investigated whether this combination of a DNA-damaging chemotherapy plus olaparib is effective in PROC regardless BRCA status.

Patients And Methods: Patients with high-grade serous or endometrioid ovarian carcinoma and one previous PROC recurrence were enrolled regardless of BRCA status. Read More

Life Sci 2021 Jul 27:119856. Epub 2021 Jul 27.

Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11751, Egypt.

Aim: Hepatotoxicity is a critical consequence of the iron overload conditions such as hemochromatosis and blood transfusion-requiring anemia. Iron induces hepatotoxicity largely through disruption of cellular redox homeostasis and induction of inflammatory responses. The present work explored the hepatoprotective activity of the bio-active flavone galangin against iron-evoked hepatotoxicity. Read More

Hum Pathol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pathology, Haukeland University Hospital, Jonas Lies Vei 65, 5021 Bergen, Norway; Department of Clinical Medicine, University of Bergen, Jonas Lies Vei 87, 5021 Bergen, Norway. Electronic address:

The polymer polyvinylpyrrolidone (PVP) is an excipient widely used in prescription drugs. Depending on the molecular weight (MW), parenterally administered PVP may accumulate in various tissues. Consequently, moderate and high MW PVP has only been used in oral preparations since the late 1970s. Read More

Clin Biochem 2021 Jul 27. Epub 2021 Jul 27.

Hematology Research Laboratory, Department of Hematology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China. Electronic address:

Lancet Haematol 2021 Aug;8(8):e562-e571

Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address:

Background: Relapsed or refractory classical Hodgkin lymphoma could be treated with multiagent salvage chemotherapy followed by autologous haematopoietic stem-cell transplantation. The aim of this study is to establish the safety and activity of dose-dense brentuximab vedotin combined with ifosfamide, carboplatin, and etoposide (BV-ICE) chemotherapy in second-line treatment of classical Hodgkin lymphoma.

Methods: We conducted a single-arm, open-label, phase 1/2 study of dose-dense BV-ICE at the Seattle Cancer Care Alliance, University of Washington (Seattle, WA, USA). Read More

J Sci Food Agric 2021 Jul 30. Epub 2021 Jul 30.

Department of Physiology, University of Granada, Granada, Spain.

Background: Iron deficiency and iron overload can affect the normal functioning of the innate and adaptive immune responses, and fermented milk products may enhance immune functions, but little is known about the effect of fermented milks on modulation of immune response during iron-deficiency anemia and recovery with normal or high dietary iron intake. 80 male Wistar rats were divided randomly assigned to a control group fed the standard diet and to an anemic group fed a diet deficit in iron. Control and anemic groups were fed for 30 days with diets based on a fermented goat's or cow's milk product, with iron normal content or iron overload. Read More

Blood 2021 Jul 30. Epub 2021 Jul 30.

New York Blood Center, New York, New York, United States.

Sickle Cell Disease (SCD) is characterized by hemolytic anemia, which can trigger oxidative stress, inflammation, and tissue injury that contributes to disease complications. Bone marrow mesenchymal stromal cells (MSCs) tightly regulate hematopoietic stem cell (HSC) homeostasis in health and disease but their functionality in SCD remains unclear. We identified for the first time murine SCD MSCs to have altered gene signatures, reduced stem cell properties, and increased oxidative stress, due in part to hemolysis. Read More

Cancer Sci 2021 Jul 30. Epub 2021 Jul 30.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Recent genome-wide studies have revealed that aging or chronic inflammation can cause clonal expansion of cells in normal tissues. Clonal hematopoiesis has been the most intensively studied form of clonal expansion in the last decade. Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related phenomenon observed in elderly individuals with no history of hematological malignancy. Read More

Clin Toxicol (Phila) 2021 Jul 30:1-9. Epub 2021 Jul 30.

Clinical Toxicology Research Group, University of Newcastle, Newcastle, Australia.

Background: Snakebite-associated thrombotic microangiopathy (TMA) occurs in a subset of patients with venom-induced consumption coagulopathy (VICC) following snakebite. Acute kidney injury (AKI) is the commonest end-organ manifestation of TMA. The epidemiology, diagnostic features, outcomes, and effectiveness of interventions including therapeutic plasma-exchange (TPE), in snakebite-associated TMA are poorly understood. Read More

Arthritis Rheumatol 2021 Jul 30. Epub 2021 Jul 30.

B. Shine Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel.

A 40-year-old previously healthy woman presented to the Rheumatology department with suspected arthritis because of bilateral lower limb pain, swelling, and difficulty walking for the last six months. Physical examination revealed multiple subcutaneous hematomas, gingival hyperplasia, bilateral knee effusion, lower extremities muscle weakness, and right hip joint movement limitation. The laboratory tests were remarkable only for iron and folate deficiency normocytic anemia (Hemoglobin 9 mg/dl). Read More

Mol Oncol 2021 Jul 30. Epub 2021 Jul 30.

Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA.

Individuals with Fanconi anemia (FA), a rare genetic bone marrow failure syndrome, have an increased risk of young-onset head and neck squamous-cell carcinomas (SCCs) and esophageal SCC. The FA DNA repair pathway is activated upon DNA damage induced by acetaldehyde, a chief alcohol metabolite and one of the major carcinogens in humans. However, the molecular basis of acetaldehyde-induced genomic instability in SCCs of the head and neck and of the esophagus in FA remains elusive. Read More

J Prim Care Community Health 2021 Jan-Dec;12:21501327211034374

College of Health and Medical Science, School of public health, Dilla University, Dilla, Ethiopia.

Background: Indoor air pollution from different fuel types has been linked with different adverse pregnancy outcomes. The study aimed to assess the link between indoor air pollution from different fuel types and anemia during pregnancy in Ethiopia.

Method: We have used the secondary data from the 2016 Ethiopian Demographic and Health Survey data. Read More

Oncologist 2021 Jul 30. Epub 2021 Jul 30.

Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

Background: With increased use of immune checkpoint inhibitors (ICIs) among cancer patients, there is substantial interest in understanding clinical, economics outcomes and management of immune-related adverse events (irAEs).

Patients And Methods: A retrospective study was conducted using Premier Healthcare Database, a US national hospital discharge database, from March 1, 2015 through December 31, 2017. The database comprises more than 880 million inpatient and hospital-based outpatient encounters with more than 200 million unique patients reported by 966 hospitals. Read More

Mol Cell Biochem 2021 Jul 29. Epub 2021 Jul 29.

Faculty of Medical Sciences, Department of Internal Medicine, University of Kragujevac, Kragujevac, Serbia.

The aim of our study was to investigate the effects of one-month consumption of polyphenol-rich standardized Aronia melanocarpa extract (SAE) on redox status in anemic hemodialysis patients. The study included 30 patients (Hb < 110 g/l, hemodialysis or hemodiafiltration > 3 months; > 3 times week). Patients were treated with commercially available SAE in a dose of 30 ml/day, for 30 days. Read More

Am J Prev Cardiol 2020 Dec 24;4:100131. Epub 2020 Nov 24.

School of Development Studies, Tata Institute of Social Sciences, Mumbai, India.

Background: In recent years, hysterectomy has received increased attention in health policy debates in India. On the other hand, based non-communicable disease specific data for India, in 2011, WHO portray a grim picture and recommended to the government a 20% reduction in hypertension by 2020; however, the trends show that it is increasing. Yet, to date, there has not been a single nationally representative study of hypertension prevalence among women who undergo a hysterectomy. Read More

Case Rep Nephrol Dial 2021 May-Aug;11(2):195-203. Epub 2021 Jul 9.

Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Lodz, Lodz, Poland.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon life-threatening condition caused by an uncontrolled immunological response. It can develop secondary to malignancies, infections, systemic diseases, and immunosuppression. Multiple risk factors may present in kidney transplant recipients; however, the cases of HLH in this population have been described sparsely. Read More

Case Rep Nephrol Dial 2021 May-Aug;11(2):167-175. Epub 2021 Jul 1.

East Georgia Kidney and Hypertension, Augusta, Georgia, USA.

Excessive intake of zinc is a known but often forgotten cause of copper deficiency, and its consequences in the context of end-stage renal disease (ESRD) are not widely discussed. Zinc-induced copper deficiency (ZICD) can result in erythropoietin (EPO)-resistant anemia and may not be considered as a possible etiology when conducting the work-up. We present a case wherein an ESRD patient had been receiving excess zinc for several months and subsequently experienced EPO-resistant anemia. Read More

Cureus 2021 Jun 23;13(6):e15873. Epub 2021 Jun 23.

Obstetrics and Gynaecology, Post Graduate Institute of Medical Education & Research (PGIMER) Chandigarh, Chandigarh, IND.

Developmental anomalies of the genital tract result from defective fusion and absorption of various parts of Mullerian ducts in fetal life. Rudimentary horn pregnancy is a rare occurrence of one in 76,000 and one in 160,000. We present a case of a 24-year-old primigravida with ruptured rudimentary horn pregnancy initially managed in the line of an intrauterine pregnancy with severe anemia. Read More

Case Rep Endocrinol 2021 16;2021:6686312. Epub 2021 Jul 16.

Department of Pediatrics, King Abdulaziz Hospital, Ministry of National Guard-Health Affairs, Al-Ahasa, Saudi Arabia.

Fanconi anemia (FA) is a rare autosomal recessive inherited disease caused by gene mutations that are primarily involved in the response to or repair of DNA damage. FA characterizes by multiple congenital abnormalities and malformations including growth retardation, renal agenesis, absence of radial bones and thumbs as well, progressive bone marrow failure, irregular skin pigmentation patterns, and increased susceptibility to cancer. FANCD2 gene mutation is believed to be one of the causative mutations in Fanconi anemia, and despite many case reports that link the FANC gene mutation to multiple congenital anomalies and disease, there is no case report found to link it with genitalia abnormalities. Read More

World J Diabetes 2021 Jul;12(7):975-996

Department of Nephrology, Clinic for Internal Medicine, University Medical Centre Maribor, Maribor 2000, Slovenia.

The prevalence and burden of diabetes mellitus and chronic kidney disease on global health and socioeconomic development is already heavy and still rising. Diabetes mellitus by itself is linked to adverse cardiovascular events, and the presence of concomitant chronic kidney disease further amplifies cardiovascular risk. The culmination of traditional (male gender, smoking, advanced age, obesity, arterial hypertension and dyslipidemia) and non-traditional risk factors (anemia, inflammation, proteinuria, volume overload, mineral metabolism abnormalities, oxidative stress, ) contributes to advanced atherosclerosis and increased cardiovascular risk. Read More

World J Diabetes 2021 Jul;12(7):916-931

Diabetes Research Institute Federation (DRIF), Division of Endocrinology and Diabetes, CTO Alesini Hospital, Department of Systems Medicine, University of Rome Tor Vergata, Rome 00145, Italy.

To date, metformin remains the first-line oral glucose-lowering drug used for the treatment of type 2 diabetes thanks to its well-established long-term safety and efficacy profile. Indeed, metformin is the most widely used oral insulin-sensitizing agent, being prescribed to more than 100 million people worldwide, including patients with prediabetes, insulin resistance, and polycystic ovary syndrome. However, over the last decades several observational studies and meta-analyses have reported a significant association between long-term metformin therapy and an increased prevalence of vitamin B12 deficiency. Read More

Pediatrics 2021 Jul 29. Epub 2021 Jul 29.

Pediatric Infectious Diseases, University of California San Francisco, Benioff Children's Hospital, Oakland, California

A 12-year-old Hispanic girl presented with fatigue, lightheadedness, and intermittent headaches. She was depressed and appeared pale to her mother. Her examination was unremarkable except for palpebral conjunctival pallor and was otherwise noncontributory. Read More

J Nucl Med 2021 Jul 29. Epub 2021 Jul 29.

Department of Theranostics and Nuclear Medicine, St Vincent's Hospital, Australia.

Lutetium PSMA-617 (Lu-PSMA-617) is an effective therapy for metastatic castrate-resistant prostate cancer (mCRPC). However, treatment resistance occurs frequently and combination therapies may improve outcomes. We report the final safety and efficacy results of a phase I/II study combining Lu-PSMA-617 with idronoxil (NOX66), a radiosensitiser, and examined potential clinical, blood-based and imaging biomarkers. Read More

Malar J 2021 Jul 29;20(1):333. Epub 2021 Jul 29.

Department of Zoology and Animal Physiology, University of Buea, Buea, Cameroon.

Background: Insecticide-treated nets (ITNs) are the most widely used interventions for malaria control in Africa. The aim of this study was to assess the ownership and utilization of ITNs and the knowledge of malaria and their effects on malariometric and haematological indices in children living in the Mount Cameroon area.

Methods: A community-based cross-sectional study involving a total of 405 children aged between 6 months and 14 years living in Batoke-Limbe was carried out between July and October 2017. Read More

BMC Public Health 2021 Jul 29;21(1):1480. Epub 2021 Jul 29.

MRC Clinical Trials Unit at University College London, 90 High Holborn, London, WC1V 6LJ, UK.

Background: Severe anaemia (haemoglobin < 6 g/dL) is a leading cause of recurrent hospitalisation in African children. We investigated predictors of readmission in children hospitalised with severe anaemia in the TRACT trial (ISRCTN84086586) in order to identify potential future interventions.

Methods: Secondary analyses of the trial examined 3894 children from Uganda and Malawi surviving a hospital episode of severe anaemia. Read More

BMC Gastroenterol 2021 Jul 29;21(1):301. Epub 2021 Jul 29.

Department of Gastroenterology, 424 General Military Hospital, Thessaloniki, Greece.

Gerontology 2021 Jul 29:1-8. Epub 2021 Jul 29.

Department of Neurology, Taikang Xianlin Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Introduction: Anemia is a common condition encountered in acute ischemic stroke, and only a few pieces of evidence has been produced suggesting its possible association with short-term mortality have been produced. The study sought to assess whether admission anemia status had any impact on short-term clinical outcome among oldest-old patients with acute ischemic stroke.

Materials And Methods: A retrospective review of Electronic Medical Recording System was performed in 2 tertiary hospitals. Read More

Vet Parasitol 2021 Jul 24;298:109532. Epub 2021 Jul 24.

Tick Fever Centre, Wacol, QLD, 4076, Australia.

Theileria orientalis is a tick-borne protozoal parasite causing anaemia and death in susceptible cattle. This investigation aimed to confirm whether immunisation with the "benign" buffeli genotype of T. orientalis could reduce the parasitaemia of the virulent ikeda genotype. Read More

Interact Cardiovasc Thorac Surg 2021 Jul 29. Epub 2021 Jul 29.

Division of Cardiovascular Sciences, University of Manchester, ERC, Manchester University Hospital NHS Foundation Trust, Manchester, UK.

Objectives: The ability to accurately estimate the risk of peri-operative mortality after lung resection is important. There are concerns about the performance and validity of existing models developed for this purpose, especially when predicting mortality within 90 days of surgery. The aim of this study was therefore to develop a clinical prediction model for mortality within 90 days of undergoing lung resection. Read More

Expert Rev Hematol 2021 Jul 29:1-12. Epub 2021 Jul 29.

Professor of Internal Medicine, Department of Clinical Sciences and Community, University of Milan, Milan, Italy.

Introduction: In β-thalassemia, imbalanced globin synthesis causes reduced red blood cell survival and ineffective erythropoiesis. Suppressed hepcidin levels increase ferroportin-mediated iron transport in enterocytes, causing increased iron absorption and potentially iron overload. Low hepcidin also stimulates ferroportin-mediated iron release from macrophages, increasing transferrin saturation (TSAT), potentially forming non-transferrin-bound iron, which can be toxic. Read More