55,655 results match your criteria Anemia in Elderly Persons


Blood management in hip fractures; are we leaving it too late? A retrospective observational study.

BMC Geriatr 2019 Mar 12;19(1):79. Epub 2019 Mar 12.

School of Health and Sports Science, University of the Sunshine Coast, Sippy Downs, Queensland, 4556, Australia.

Background: Anaemia in hip fracture patients has been associated with increased risk of allogenic blood transfusion (ABT), poorer functional outcomes and increased mortality. Few studies have reported the prevalence of anaemia on admission or its progression prior to surgery in this cohort. We aimed to measure the prevalence of anaemia on admission in older persons who sustain a hip fracture, identify if anaemia develops or progresses prior to surgery, and to report associations with outcome. Read More

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http://dx.doi.org/10.1186/s12877-019-1099-xDOI Listing

Multiple risks analysis for aplastic anemia in Zhejiang, China: A case-control study.

Medicine (Baltimore) 2019 Feb;98(8):e14519

Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University.

To understand the risks associated with aplastic anemia (AA) in 4 cities of Zhejiang Province, China, with special focus on the joint contributions of multiple risks.Based on an Electronic Data Capture (EDC), a case control study was carried out. Data regarding socio-demographic, diseases history, living habits, and exposures to toxic substances, etc. Read More

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http://dx.doi.org/10.1097/MD.0000000000014519DOI Listing
February 2019
4 Reads

Low Incidence of Hospital-Onset Infection in Sickle Cell Disease.

N Engl J Med 2019 02;380(9):887-888

New York Medical College, Valhalla, NY

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http://dx.doi.org/10.1056/NEJMc1815711DOI Listing
February 2019
1 Read
55.873 Impact Factor

On the discriminatory and predictive accuracy of the RDT against the microscopy in the diagnosis of malaria among under-five children in Nigeria.

Malar J 2019 Feb 21;18(1):46. Epub 2019 Feb 21.

Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Accurate identification of malaria cases is crucial to the management of cases and the eventual success of malaria eradication agenda. This study is designed to evaluate the discriminatory and predictive accuracy of malaria rapid diagnostic tests (RDTs) in Nigeria.

Methods: The data obtained during the 2015 Nigeria Malaria Indicator Survey was used to quantify the discriminatory accuracy of the RDT against the microscopy through the analysis of its sensitivity, specificity, positive (LR+) and negative (LR-) likelihood ratio. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2678-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385408PMC
February 2019
5 Reads

Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.

N Engl J Med 2019 02;380(8):741-751

From the Massachusetts General Hospital Cancer Center (A.B., S.J.I.) and Dana-Farber Cancer Institute (S.M.T.), Harvard Medical School, Boston; Vanderbilt-Ingram Cancer Center, Nashville (I.A.M., V.G.A.); Weill Cornell Medical College (L.T.V.) and New York-Presbyterian-Columbia University Irving Medical Center (K.K.), New York; University of Colorado Cancer Center, Aurora (J.R.D.); Texas Oncology, Baylor University Medical Center, US Oncology, Dallas (J.O.); Orlando Health University of Florida Health Cancer Center, Orlando (R.L.M., N.C.S.); Yale University School of Medicine, New Haven, CT (A.D.S.); University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco (H.S.R.); Immunomedics, Morris Plains, NJ (D.M.G., R.I., S.W., R.M.S., W.A.W.); and AIS Consulting, Ann Arbor, MI (A.M.S.).

Background: Standard chemotherapy is associated with low response rates and short progression-free survival among patients with pretreated metastatic triple-negative breast cancer. Sacituzumab govitecan-hziy is an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell-surface antigen 2 (Trop-2), with SN-38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan-hziy enables delivery of high concentrations of SN-38 to tumors. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1814213
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http://dx.doi.org/10.1056/NEJMoa1814213DOI Listing
February 2019
7 Reads

FOOD INTAKE, NUTRITIONAL STATUS AND GASTROINTESTINAL SYMPTOMS IN CHILDREN WITH CEREBRAL PALSY.

Arq Gastroenterol 2018 Oct-Dec;55(4):352-357

Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Gastroenterologia Pediátrica, São Paulo, SP, Brasil.

Background: Cerebral palsy may be associated with comorbidities such as undernutrition, impaired growth and gastrointestinal symptoms. Children with cerebral palsy exhibit eating problems due to the effect on the anatomical and functional structures involved in the eating function resulting in malnutrition.

Objective: The aim of this study was to investigate the association between food intake, nutritional status and gastrointestinal symptoms in children with cerebral palsy. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-78DOI Listing
March 2019
2 Reads

Pros and cons of gastric bypass surgery in individuals with obesity and type 2 diabetes: nationwide, matched, observational cohort study.

BMJ Open 2019 Jan 15;9(1):e023882. Epub 2019 Jan 15.

Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.

Objectives: Long-term effects of gastric bypass (GBP) surgery have been presented in observational and randomised studies, but there are only limited data for persons with obesity and type 2 diabetes mellitus (T2DM) regarding postoperative complications.

Design: This is a nationwide observational study based on two quality registers in Sweden (National Diabetes Register, NDR and Scandinavian Obesity Surgery Register, SOReg) and other national databases.

Setting: After merging the data, we matched individuals with T2DM who had undergone GBP with those not surgically treated for obesity on propensity score, based on sex, age, body mass index (BMI) and calendar time. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340417PMC
January 2019
2 Reads

Case 5-2019: A 48-Year-Old Woman with Delusional Thinking and Paresthesia of the Right Hand.

N Engl J Med 2019 Feb;380(7):665-674

From the Departments of Psychiatry (C.H., O.F., A.I.), Radiology (B.P.L.), Hematology (J.C.T.C.), and Pathology (J.M.B.), Massachusetts General Hospital, and the Departments of Psychiatry (C.H., O.F., A.I.), Radiology (B.P.L.), Hematology (J.C.T.C.), and Pathology (J.M.B.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1807495DOI Listing
February 2019
2 Reads

Very severe tungiasis in Amerindians in the Amazon lowland of Colombia: A case series.

PLoS Negl Trop Dis 2019 02 7;13(2):e0007068. Epub 2019 Feb 7.

Institute of Microbiology and Infection Immunology, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Tungiasis is a parasitic skin disease caused by penetrating female sand fleas. By nature, tungiasis is a self-limiting infection. However, in endemic settings re-infection is the rule and parasite load gradually accumulates over time. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366737PMC
February 2019

GDF11 is increased in patients with aplastic anemia.

Hematology 2019 Dec;24(1):331-336

a Department of Hematology, General Hospital , Tianjin Medical University , Tianjin , People's Republic of China.

Object: To explore the critical role of growth differentiation factor 11 (GDF11) in the pathobiology of aplastic anemia (AA).

Methods: We have examined the serum GDF11 levels for 79 AA patients and 30 healthy controls. A total of 79 AA patients, which included 29 new diagnosed (untreated) cases, 14 cases with no response, 21 partial remission (PR) cases and 15 complete remission (CR) cases after immunosuppressive therapy (IST). Read More

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https://www.tandfonline.com/doi/full/10.1080/16078454.2019.1
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http://dx.doi.org/10.1080/16078454.2019.1574386DOI Listing
December 2019
5 Reads

The Devil Is in the Details.

N Engl J Med 2019 Feb;380(6):581-586

From the Infectious Diseases Unit (E.B.-C.), the Adult Nephrology Unit (L.S., A.B.), and the Department of Hematology (A.T.), Shaare Zedek Medical Center, Hebrew University-Hadassah School of Medicine, and the Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center (M.K.) - both in Jerusalem.

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http://dx.doi.org/10.1056/NEJMcps1808400DOI Listing
February 2019
1 Read

Primary cardiac synovial sarcoma that was continuous with the mitral valve caused severe thrombocytopenia: a case report.

J Cardiothorac Surg 2019 Feb 4;14(1):30. Epub 2019 Feb 4.

Cardiac Surgery Department, Peking University People's Hospital, Beijing, 100044, China.

Background: Primary cardiac sarcomas are exceedingly rare, and they commonly result in nonspecific constitutional symptoms such as shortness of breath, weight loss, and anaemia-related fatigue and malaise. However, thrombocytopenia has very rarely been reported in association with cardiac tumours, either benign or malignant. We report one case of primary cardiac synovial sarcoma continuous with the mitral valve, which was accompanied by severe thrombocytopenia, and the platelet counts returned rapidly to a normal range early after tumour excision and without any special therapies. Read More

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http://dx.doi.org/10.1186/s13019-019-0852-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360734PMC
February 2019
13 Reads

Incidence and predictors of LTFU among adults with TB/HIV co-infection in two governmental hospitals, Mekelle, Ethiopia, 2009-2016: survival model approach.

BMC Infect Dis 2019 Feb 4;19(1):107. Epub 2019 Feb 4.

Department of Biostatistics, School of Public Health, College of Health Sciences, Mekelle University, P.O. Box: 1871, Mekelle, Ethiopia.

Background: Lost to follow-up (LTFU) negatively affects the treatment success of Anti-Retroviral Therapy (ART) and thus, increases Tuberculosis-Human Immunodeficiency Virus (TB/HIV) related morbidity, mortality and hospitalization. However, the incidence and predictors of loss to follow up (LTFU) among adults with TB/HIV co-infection have not yet well-investigated in Ethiopia. Therefore, this study was aimed at investigating the incidence and predictors of LTFU in the study setting in particular. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3756-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360725PMC
February 2019
5 Reads

Antibody persistence 5 years after a 13-valent pneumococcal conjugate vaccine in asplenic patients with β-thalassemia: assessing the need for booster.

Ann Hematol 2019 Mar 25;98(3):775-779. Epub 2019 Jan 25.

Infectious Diseases Unit, 1st Department of Paediatrics, Aghia Sofia Children's Hospital, National and Kapodistrian University of Athens, Thivon & Levadias Str, 115 27, Athens, Greece.

Streptococcus pnemoniae is a major cause of morbidity and mortality among splenectomised patients with β-thalassemia major. We have previously shown that a 13-valent pneumococcal conjugate vaccine (PCV13) induces robust early immune responses in such patients, while history of repeated immunisations with the 23-valent polysaccharide pneumococcal vaccine (PPSV23) results in attenuation of the response to PCV13. However, the duration of vaccine-induced protection in splenectomised thalassemic patients and the associated need for booster immunisation remains unclear. Read More

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http://link.springer.com/10.1007/s00277-019-03615-z
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http://dx.doi.org/10.1007/s00277-019-03615-zDOI Listing
March 2019
4 Reads

Concomitant cryoglobulinemic vasculitis and cold agglutinin disease successfully treated with bortezomib: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14201

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Concomitant cryoglobulinemic vasculitis and cold agglutinin disease (CAD) is an extremely uncommon clinical scenario. The role of bortezomib in the treatment of cryoglobulinemic vasculitis needs further investigation.

Patient Concerns: A 72-year-old Chinese woman presented with a 25-year history of cyanosis of the extremities after cold exposure, which worsened and was accompanied with purpuric skin lesions and proteinuria in recent years. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901250-0004
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http://dx.doi.org/10.1097/MD.0000000000014201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358358PMC
January 2019
7 Reads

Renal dysfunction and anemia associated with long-term imatinib treatment in patients with chronic myelogenous leukemia.

Int J Hematol 2019 Mar 24;109(3):292-298. Epub 2019 Jan 24.

Division of Hematology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Knowledge of the toxicity profile of long-term treatment with imatinib is limited. In the present study, we sought to evaluate renal function and hemoglobin levels during long-term imatinib treatment. Eighty-two patients with chronic myelogenous leukemia in chronic phase who had been on imatinib for over 5 years were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s12185-019-02596-zDOI Listing
March 2019
10 Reads

Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion.

Malar J 2019 Jan 23;18(1):20. Epub 2019 Jan 23.

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.

Background: Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. However, primaquine and the other 8-aminoquinolines cause dose-dependent haemolysis in subjects with G6PD deficiency, an X-linked disorder of red blood cells that is very common in populations living in tropical and subtropical areas. In order to inform safer use of 8-aminoquinolines in the Greater Mekong Subregion, a multi-centre study was carried out to assess the prevalence of G6PD deficiency and to identify the main G6PD variants in samples collected in Cambodia, Lao PDR, Myanmar, Thailand and Vietnam. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2652-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343352PMC
January 2019
7 Reads

Reducing the number of unnecessary routine laboratory tests through education of internal medicine residents.

Postgrad Med J 2018 Dec 22;94(1118):716-719. Epub 2019 Jan 22.

Spectrum Health Office of Research Administration, Grand Rapids, Michigan, USA.

Introduction: The Choosing Wisely guidelines advise against ordering routine blood tests for hospitalised patients unless they change management. Unnecessary testing can lead to adverse effects (eg, iatrogenic anaemia, poor sleep quality, risk for infections and increased cost of care).

Methods: An 8-week quality initiative aimed at reducing unnecessary blood tests was implemented in three internal medicine resident inpatient services. Read More

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http://pmj.bmj.com/lookup/doi/10.1136/postgradmedj-2018-1357
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http://dx.doi.org/10.1136/postgradmedj-2018-135784DOI Listing
December 2018
11 Reads

Meal Improves Iron Status of Childbearing Age Women and Prevents Stunting in Their Toddlers in Northern Ghana.

Nutrients 2019 Jan 19;11(1). Epub 2019 Jan 19.

Food Science and Human Nutrition Department, Michigan State University, EL, MI 48824, USA.

Globally, iron deficiency (ID) is the most common form of nutritional deficiency, particularly in young children and childbearing age women. ID can lead to stunting and impaired cognitive development in children, as well as adverse maternal health and birth outcomes. In this study, the efficacy of an alternative food-to-food fortification utilizing indigenous iron-rich food sources was investigated in a quasi-experimental study. Read More

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http://dx.doi.org/10.3390/nu11010198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357016PMC
January 2019
3 Reads

Bead-based assays to simultaneously detect multiple human inherited blood disorders associated with malaria.

Malar J 2019 Jan 21;18(1):14. Epub 2019 Jan 21.

Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK.

Background: Glucose-6-phosphate dehydrogenase deficiency (G6PDd), haemoglobin C (HbC) and S (HbS) are inherited blood disorders (IBD) common in populations in malaria endemic areas. All are associated to some degree with protection against clinical malaria whilst additionally G6PDd is associated with haemolysis following treatment with 8-aminoquinolines. Measuring the prevalence of these inherited blood disorders in affected populations can improve understanding of disease epidemiology. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2648-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341711PMC
January 2019
5 Reads

Denosumab effects on serum levels of the bone morphogenetic proteins antagonist noggin in patients with transfusion-dependent thalassemia and osteoporosis.

Hematology 2019 Dec;24(1):318-324

b Department of Clinical Therapeutics , School of Medicine, National and Kapodistrian University of Athens , Athens , Greece.

Introduction: Noggin is an antagonist of bone morphogenetic proteins (BMPs) and has a strong effect on osteogenesis. Osteoporosis is a common complication of transfusion dependent beta-thalassemia (TDT) and denosumab has been recently emerged as a promising therapeutic option. This was a post hoc investigation of serum noggin levels among TDT patients with osteoporosis who participated in a randomized, placebo-control, phase 2b study. Read More

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http://dx.doi.org/10.1080/16078454.2019.1570617DOI Listing
December 2019
3 Reads

Short-term outcomes associated with drain use in shoulder arthroplasties: a prospective, randomized controlled trial.

J Shoulder Elbow Surg 2019 Feb;28(2):205-211

Department of Orthopaedics, New York Presbyterian, Columbia University Medical Center, New York, NY, USA.

Background: This study examined the immediate outcomes during the perioperative period associated with drains in the setting of total shoulder arthroplasty or reverse shoulder arthroplasty. We hypothesized that drain use would result in lower postoperative hemoglobin and hematocrit levels that would increase transfusion rates and longer hospital stays that would increase hospital costs.

Methods: The study prospectively randomized 100 patients (55% women; average age, 69. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10582746183077
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http://dx.doi.org/10.1016/j.jse.2018.10.014DOI Listing
February 2019
5 Reads
2.289 Impact Factor

A nomogram for predicting bowel obstruction in preoperative colorectal cancer patients with clinical characteristics.

World J Surg Oncol 2019 Jan 18;17(1):21. Epub 2019 Jan 18.

Department of Surgical Oncology and General Surgery, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang City, 110001, People's Republic of China.

Background: Bowel obstruction (BO) is a complication that commonly affects patients with colorectal cancer (CRC). BO causes severe outcomes, and its treatment leads to a dilemma for many surgeons. Moreover, the factors correlated to BO in preoperative CRC patients remain unclear. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1
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http://dx.doi.org/10.1186/s12957-019-1562-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339443PMC
January 2019
8 Reads
1.200 Impact Factor

A cohort study of immune and hematopoietic functionality changes in severe aplastic anemia patients treated with immunosuppressive therapy.

Medicine (Baltimore) 2019 Jan;98(3):e14149

Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.

To investigate if variations in immune and hematopoietic parameters correlated with immunosuppressive therapy (IST) in severe aplastic anemia (SAA) patients.A total of 115 SAA patients who received IST were included. Their immune and hematopoietic functionality changes had been evaluated at 0, 0. Read More

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http://dx.doi.org/10.1097/MD.0000000000014149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370062PMC
January 2019
8 Reads

Isolated IgG4-related gastric disease presenting as diffuse gastric wall thickening with ulcer.

J Radiol Case Rep 2018 Sep 30;12(9):9-20. Epub 2018 Sep 30.

Department of Anatomical Pathology, Singapore General Hospital, Singapore.

An 81-year-old male presented with loss of appetite, early satiety and iron deficiency anaemia. A computed tomography (CT) scan of the abdomen and pelvis during initial work-up revealed diffuse gastric mural thickening associated with a large ulcer and adjacent gastro-hepatic lymphadenopathy. The CT appearances, together with the clinical features, were highly suspicious for an infiltrative type of gastric malignancy. Read More

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http://radiologycases.com/index.php/radiologycases/article/v
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http://dx.doi.org/10.3941/jrcr.v12i9.3493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312045PMC
September 2018
8 Reads

Germline mutations in cancer susceptibility genes in high grade serous ovarian cancer in Serbia.

J Hum Genet 2019 Apr 16;64(4):281-290. Epub 2019 Jan 16.

Institute for Oncology and Radiology of Serbia, Pasterova 14, 11 000, Belgrade, Serbia.

Clinical criteria for genetic testing of genes other than BRCA1/2 in epithelial ovarian cancer (EOC) still do not exist. We assessed the frequency and predictors of deleterious mutations in 19 cancer predisposition genes in high-grade serous ovarian cancer (HGSOC) in Serbia. Next-generation sequencing was used to identify germline mutations in the whole coding regions of a gene panel. Read More

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http://www.nature.com/articles/s10038-019-0562-z
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http://dx.doi.org/10.1038/s10038-019-0562-zDOI Listing
April 2019
6 Reads

Should postoperative haemoglobin and potassium levels be checked routinely following blood-conserving primary total joint arthroplasty?

Bone Joint J 2019 Jan;101-B(1_Supple_A):25-31

Joint Implant Surgeons, Inc., White Fence Surgical Suites, and Mount Carmel Health System, New Albany, Ohio, USA.

Aims: Despite declining frequency of blood transfusion and electrolyte supplementation following total joint arthroplasty, postoperative blood analyses are still routinely ordered for these patients. This study aimed to determine the rate of blood transfusion and electrolyte restoration in arthroplasty patients treated with a perioperative blood conservation protocol and to identify risk factors that would predict the need for transfusion and electrolyte supplementation.

Patients And Methods: Patients undergoing primary total joint arthroplasty of the hip or knee between July 2016 and February 2017 at a single institution were included in the study. Read More

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http://dx.doi.org/10.1302/0301-620X.101B1.BJJ-2018-0554.R1DOI Listing
January 2019
2 Reads

Safety and activity of ibrutinib in combination with nivolumab in patients with relapsed non-Hodgkin lymphoma or chronic lymphocytic leukaemia: a phase 1/2a study.

Lancet Haematol 2019 Feb 11;6(2):e67-e78. Epub 2019 Jan 11.

Department of Hematology, Jagiellonian University, Krakow, Poland.

Background: Preclinical studies have shown synergistic antitumour effects between ibrutinib and immune-checkpoint blockade. The aim of this study was to assess the safety and activity of ibrutinib in combination with nivolumab in patients with relapsed or refractory B-cell malignant diseases.

Methods: We did a two-part, open-label, phase 1/2a study at 21 hospitals in Australia, Israel, Poland, Spain, Turkey, and the USA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523026183021
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http://dx.doi.org/10.1016/S2352-3026(18)30217-5DOI Listing
February 2019
10 Reads

Statin therapy and erythropoiesis-stimulating agent hyporesponsiveness in patients with nondialysis chronic kidney disease: A retrospective study in Beijing, China.

Medicine (Baltimore) 2019 Jan;98(2):e13981

Department of Nephrology, Peking University People's Hospital, Beijing, China.

Erythropoiesis-stimulating agents (ESAs) are frequently used among patients with renal anemia, while a significant proportion of patients exhibit ESA hyporesponsiveness despite adequate dosing. Previous studies have suggested an inverse association between ESA hyporesponsiveness and statin use among patients receiving dialysis therapy. However, studies based on predialysis patients are extremely limited. Read More

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http://dx.doi.org/10.1097/MD.0000000000013981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336583PMC
January 2019
1 Read

Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d'Ivoire.

PLoS Negl Trop Dis 2019 01 10;13(1):e0007086. Epub 2019 Jan 10.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Introduction: Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host's immune response and susceptibility and thus impact on morbidity. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343929PMC
January 2019
5 Reads

Immunosuppressive therapy with rabbit antithymocyte globulin therapy for acquired aplastic anemia: a multi-institutional retrospective study in Japanese adult patients.

Int J Hematol 2019 Mar 9;109(3):278-285. Epub 2019 Jan 9.

Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

We retrospectively analyzed efficacy and safety of therapy with rabbit antithymocyte globulin (rATG) in combination with cyclosporine A (CsA) in 30 Japanese adult patients with acquired aplastic anemia (AA) in the Kyoto Clinical Hematology Study Group. The median observation period was 31 months and the median age of the patients was 54 years. The objective response rates (ORRs) to rATG plus CsA increased over time until 18 months after the start of treatment; the rate of achievement of better than partial response at 18 months was 66. Read More

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http://link.springer.com/10.1007/s12185-018-02583-w
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http://dx.doi.org/10.1007/s12185-018-02583-wDOI Listing
March 2019
7 Reads

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura.

N Engl J Med 2019 01 9;380(4):335-346. Epub 2019 Jan 9.

From the Department of Haematology, University College London Hospitals, Cardiometabolic Program, National Institute for Health Research UCLH-UCL Biomedical Research Center, London (M.S.); the Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); Fondazione Istituti di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, and the Department of Pathophysiology and Transplantation, University of Milan, Milan (F.P.); the Department of Hematology, Saint-Antoine University Hospital, Paris (P.C.); the Department of Medicine 1, Division of Hematology and Hemostasis, Medical University of Vienna, Vienna (P.K.); the Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (J.A.K.H.); the Division of Hematology, Duke University School of Medicine, Durham, NC (A.M.); the Hematology Department, Universidad Católica de Valencia Hospital Dr. Peset, Valencia, Spain (J.R.); the Departments of Medicine and Laboratory Medicine, St. Michael's Hospital and University of Toronto, Toronto (K.P.); and Clinical Development, Ablynx, Zwijnaarde, Belgium (F.C., D.B., H.D.W., R.K.Z.).

Background: In acquired thrombotic thrombocytopenic purpura (TTP), an immune-mediated deficiency of the von Willebrand factor-cleaving protease ADAMTS13 allows unrestrained adhesion of von Willebrand factor multimers to platelets and microthrombosis, which result in thrombocytopenia, hemolytic anemia, and tissue ischemia. Caplacizumab, an anti-von Willebrand factor humanized, bivalent variable-domain-only immunoglobulin fragment, inhibits interaction between von Willebrand factor multimers and platelets.

Methods: In this double-blind, controlled trial, we randomly assigned 145 patients with TTP to receive caplacizumab (10-mg intravenous loading bolus, followed by 10 mg daily subcutaneously) or placebo during plasma exchange and for 30 days thereafter. Read More

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http://dx.doi.org/10.1056/NEJMoa1806311DOI Listing
January 2019
7 Reads

Plerixafor for the Treatment of WHIM Syndrome.

N Engl J Med 2019 01;380(2):163-170

From the Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases (D.H.M., D.V., E.C., Q.L., P.M.M.), the Laboratories of Cellular Oncology (D.V.P., C.B.B.) and Pathology (S.P.), National Cancer Institute, the Department of Laboratory Medicine, Clinical Center (K.R.C.), the National Institute of Dental and Craniofacial Research (P.J.G.), and the National Institute on Deafness and Other Communication Disorders (D.A.B.), National Institutes of Health, and Kozloff and Trout MDs (H.H.T.), Bethesda, MD; the Infectious Diseases Unit and Primary Immunodeficiencies Unit, Hospital Dona Estefânia, Pediatric University Hospital (J.F.N.), and Centro de Imunodeficiências Primárias, Academic Medical Center of Lisbon (S.L.S.), Lisbon, Portugal; and the University of Chicago Medical Center, Chicago (E.A.B., E.M.L.).

WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis), a primary immunodeficiency disorder involving panleukopenia, is caused by autosomal dominant gain-of-function mutations in CXC chemokine receptor 4 (CXCR4). Myelokathexis is neutropenia caused by neutrophil retention in bone marrow. Patients with WHIM syndrome are often treated with granulocyte colony-stimulating factor (G-CSF), which can increase neutrophil counts but does not affect cytopenias other than neutropenia. Read More

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http://dx.doi.org/10.1056/NEJMoa1808575DOI Listing
January 2019
3 Reads

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly.

Acta Cir Bras 2018 Dec;33(12):1103-1109

PhD, Associate Professor, Department of Surgery, School of Medicine, UFMG, Belo Horizonte-MG, Brazil. Scientific, intellectual, conception and design of the study; acquisition, analysis and interpretation of data; technical procedures; statistical analysis; manuscript preparation and writing; critical revision.

Purpose: To evaluate a possible relationship between the size of the spleen and values of circulating blood elements in patients with schistosomatic splenomegaly.

Methods: ixty one patients with hepatosplenic schistosomiasis mansoni underwent a clinical exam and peripheral venous blood was collected for a hemogram. The erythrocyte, hemoglobin, hematocrit, leukocyte, and platelet values were determined. Read More

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http://dx.doi.org/10.1590/s0102-865020180120000008DOI Listing
December 2018
3 Reads

Evaluation of epidemiological, clinical, and laboratory characteristics and mortality rate of patients with Crimean-Congo hemorrhagic fever in the northeast region of Turkey.

J Vector Borne Dis 2018 Jul-Sep;55(3):215-221

Department of Internal Medicine, Faculty of Medicine, Erzincan University, Erzincan, Turkey.

Background & Objectives: : Crimean-Congo hemorrhagic fever (CCHF), an illness characterized by fever and hemorrhage, is caused by a CCHF virus (CCHFV). It is an important public health problem in Turkey. The objective of this study was to evaluate the demographic, clinical, and laboratory characteristics and mortality rates of CCHF patients in the northeast region of Turkey. Read More

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http://dx.doi.org/10.4103/0972-9062.249479DOI Listing
February 2019
1 Read

Novel EZH2 mutation in a patient with secondary B-cell acute lymphocytic leukemia after deletion 5q myelodysplastic syndrome treated with lenalidomide: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e14011

FUNDALEU, Buenos Aires, Argentina.

Rationale: The gene deletion (5)(q22q35) is reported in 10-20% of myelodysplastic syndrome (MDS) cases and is associated with response to lenalidomide and favorable prognosis. The authors report here a clinical case of MDS transformation to B-cell acute lymphocytic leukemia (B-ALL) with an associated accrual of an additional mutation following treatment with lenalidomide.

Patient Concerns: A 69-year-old man presented with progressive anemia, normal white blood cell count, and thrombocytopenia consistent with MDS. Read More

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http://dx.doi.org/10.1097/MD.0000000000014011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344201PMC
January 2019
4 Reads
5.723 Impact Factor

A case report of ocular tuberculosis in a patient with membranous nephropathy.

Medicine (Baltimore) 2019 Jan;98(1):e13892

Department of Chronic Communicable Disease, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, China.

Rationale: Membranous nephropathy (MN), a chronic kidney disease (CKD), due to hypoproteinemia, malnutrition, anemia, long-term intake of immunosuppressive agents, changes in cellular immune state, and decrease in antimicrobial peptides, is a high risk for Mycobacterium tuberculosis (MTB) infection, which can cause tuberculosis (TB). TB manifests by various clinical symptoms. Ocular symptoms is a rare presentation of TB. Read More

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http://dx.doi.org/10.1097/MD.0000000000013892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344117PMC
January 2019
6 Reads

Prevalence, risk factors, and significance of iron deficiency and anemia in nonischemic heart failure patients with reduced ejection fraction from a Himachal Pradesh heart failure registry.

Indian Heart J 2018 Dec 2;70 Suppl 3:S182-S188. Epub 2018 Nov 2.

IGMC Shimla, HP, India.

Background: The study aimed to estimate the prevalence, risk determinants, and its clinical significance of iron deficiency and anemia in patients of nonischemic heart failure with reduced ejection fraction (HFrEF).

Methods: Serum ferritin, transferrin saturation, and the hemoglobin (Hb) levels were measured in 226 consecutive patients with HFrEF diagnosed based on the left ventricular ejection fraction ≤ 45% and absence of coronary artery luminal narrowing of more than 50%, in a prospective tertiary care hospital-based heart failure registry. Patients with the New York Heart Association functional class III/IV were classified as patients with advanced heart failure. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310070PMC
December 2018
2 Reads

Anemia profile in patients with congestive heart failure a hospital based observational study.

Indian Heart J 2018 Dec 30;70 Suppl 3:S101-S104. Epub 2018 Jun 30.

Department of Cardiology, Sir Ganga Ram Hospital, New Delhi 110060, India.

Objectives: Iron deficiency (ID) is an emerging problem in patients with congestive heart failure (CHF) and can be a potential therapeutic target. As ID is highly prevalent in the society, it is hypothesized that Indian patients with CHF have high prevalence of ID.

Methods: CHF patients (n = 275) were selected and underwent laboratory evaluation including hemoglobin concentration, serum iron, transferrin, ferritin, B12 and folate level. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309281PMC
December 2018

Novel nonsense mutation in the α1-globin gene [HBA1:C.49A>T] is responsible for non-deletion α-thalassemia.

Clin Biochem 2019 Jan 26;63:139-142. Epub 2018 Oct 26.

Servicio de Hematología y Hemoterapia, Hospital Clínico San Carlos, Madrid, Spain.

Background: In the α-thalassemia one of the less frequent mechanisms is the nonsense mutations, which generate the substitution of a triplet that encodes an amino acid for a stop codon and, therefore, protein synthesis stops prematurely. At present, 9 mutations of this type have been documented, 6 that affect the HBA2 gene and 3 that affect the HBA1 gene.

Objectives: We present a new mutation in CD16 of the HBA1 gene, where the change AAG>TAG generates a stop codon. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2018.10.015DOI Listing
January 2019
3 Reads

[Investigation on the nutrition and growth status of children aged 6-23 months in Yingyangbao used area of middle part in China].

Wei Sheng Yan Jiu 2018 Nov;47(6):913-917

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To investigate the nutritional and growth status of Yingyangbao used population in middle region of China.

Methods: Infants and young children were selected from Anhui, Henan, Hubei, Hunan, Jiangxi and Shanxi Provinces by multistage sampling, probability proportional to size sampling and random equidistant sampling method. There were 8245 infants and young children involved in this survey. Read More

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November 2018
11 Reads

Invasive molecular prenatal diagnosis of alpha and beta thalassemia among Hakka pregnant women.

Medicine (Baltimore) 2018 Dec;97(52):e13557

Clinical Core Laboratory.

This study is a retrospective analysis of the prenatal genetic diagnosis results of fetuses with high risk of major thalassemia to provide information for clinical genetic counseling and to better control the birth of major thalassemia child in Hakka population. Totally, 467 fetuses in at-risk pregnancies were collected from Meizhou people's hospital from January 2014 to December 2017. Genomic DNAs were extracted from peripheral blood of the couples and villus, amniotic fluid or cord blood of the fetuses. Read More

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http://dx.doi.org/10.1097/MD.0000000000013557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314693PMC
December 2018
1 Read

Lower Esophageal Sphincter-preserving Anastomosis Is an Acceptable Reconstruction Method Following Laparoscopy-assisted Proximal Gastrectomy.

Anticancer Res 2019 Jan;39(1):425-430

Department of Surgery; Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Background/aims: Our study aimed to compared 3-year results following laparoscopy-assisted proximal gastrectomy (LAPG)-double tract anastomosis (DTA) and lower esophageal sphincter-preserving LAPG (LES-LAPG).

Patients And Methods: Nine patients who underwent LES-LAPG and 23 LAPG-DTA were compared regarding 3-year follow-up complications, the anemia-related parameter and albumin levels.

Results: During the 3-year follow-up period, no patient (0%) in the LES-LAPG and six patients (6/23, 26. Read More

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http://dx.doi.org/10.21873/anticanres.13129DOI Listing
January 2019
3 Reads

Auditory brainstem response in infants with iron deficiency anemia.

Int J Pediatr Otorhinolaryngol 2019 Feb 14;117:78-81. Epub 2018 Nov 14.

Department of Speech, Language and Hearing Sciences, Sri Ramachandra Institute of Higher Education and Research (Deemed to Be University), Chennai, 600 116, India. Electronic address:

Background: Auditory brainstem response (ABR) in infants with Iron Deficiency Anemia (IDA) helps in understanding the auditory aspects of central nervous system.

Objectives: To analyse and compare absolute and interpeak latencies of ABR in infants with and without IDA.

Methods: ABR traces were obtained from 40 anemic ears and 40 non anemic ears, aged 6-24 months. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.11.017DOI Listing
February 2019
2 Reads

Improving hazard characterization in microbial risk assessment using next generation sequencing data and machine learning: Predicting clinical outcomes in shigatoxigenic Escherichia coli.

Int J Food Microbiol 2019 Mar 4;292:72-82. Epub 2018 Dec 4.

Research Group for Genomic Epidemiology, National Food Institute, Technical University of Denmark, Kemitorvet, Building 204, 2800 Kgs. Lyngby, Denmark.

The ever decreasing cost and increase in throughput of next generation sequencing (NGS) techniques have resulted in a rapid increase in availability of NGS data. Such data have the potential for rapid, reproducible and highly discriminative characterization of pathogens. This provides an opportunity in microbial risk assessment to account for variations in survivability and virulence among strains. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681605183089
Publisher Site
http://dx.doi.org/10.1016/j.ijfoodmicro.2018.11.016DOI Listing
March 2019
9 Reads

Preneoplastic Lesion in a Pancreas Allograft: Dilemma for the Pancreas Transplant Surgeon.

Transplant Proc 2018 Dec 30;50(10):3694-3697. Epub 2018 Jun 30.

Division of Transplantation, Department of Surgery, University of Minnesota Medical School, Minneapolis, MN.

Although the relationship between immunosuppression and cancer risk is well-documented, the association between immunosuppression and the development of preneoplastic lesions (PNL) is less clear. PNLs pose a unique clinical conundrum in the transplanted pancreas because their prevalence in the general population is not infrequent. We present the case of a 58-year-old man with a history of diabetes mellitus type 1 who underwent successful pancreas transplantation with bladder drainage. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.06.047DOI Listing
December 2018
1 Read

Comparison of Sirolimus Combined With Tacrolimus and Mycophenolate Mofetil Combined With Tacrolimus in Kidney Transplantation Recipients: A Meta-Analysis.

Authors:
L Gao F Xu H Cheng J Liu

Transplant Proc 2018 Dec 6;50(10):3306-3313. Epub 2018 Sep 6.

People's Hospital of Hangzhou Medical College, Hangzhou, China. Electronic address:

Purpose: The study was designed to compare the outcomes of sirolimus (SRL) combined with tacrolimus (TAC) and mycophenolate mofetil (MMF) combined with TAC in kidney transplantation recipients.

Methods: A literature search of PubMed, Embase, and Web of Science was performed to identify relevant studies, and the last update was on February 1, 2018. All studies with appropriate data comparing the SRL group with the MMF group were included. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.08.056DOI Listing
December 2018

Parvovirus B19 Infection.

N Engl J Med 2018 Dec;379(24):2361

Universitätsklinikum Carl Gustav Carus, Dresden, Germany

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http://dx.doi.org/10.1056/NEJMicm1807156DOI Listing
December 2018
1 Read

Vanishing spleen syndrome post right partial nephrectomy in a sicklemic patient.

Pan Afr Med J 2018 16;30:211. Epub 2018 Jul 16.

Division of Urology, Harlem Hospital Center, Columbia University, New York, NY, USA.

Splenic infarction after contralateral laparoscopic renal surgery has not, to our knowledge, been reported. The spleen is the most affected organ in sickle cell disease and the mechanism of auto infarction is thought to result from the crystallization of abnormal hemoglobin during periods of hypoxia or acidosis resulting in parenchymal ischemia and ultimately tissue necrosis. We report a case of 45 year old female with sickle cell disease who had an unremarkable spleen at the time of a laparoscopic right partial nephrectomy and was subsequently found to have marked diminution in her splenic volume. Read More

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http://www.panafrican-med-journal.com/content/article/30/211
Publisher Site
http://dx.doi.org/10.11604/pamj.2018.30.211.15454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294983PMC
January 2019
8 Reads

Impact of Self-Report and eGFR-Based Chronic Kidney Disease on the Risk of Chronic Kidney Disease-Related Complications and Geriatric Syndromes in Community-Dwelling Older Adults.

Kidney Blood Press Res 2018 14;43(6):1908-1918. Epub 2018 Dec 14.

Department of Medicine, National Taiwan University Hospital BeiHu branch, Taipei, Taiwan.

Background/aims: Awareness of chronic kidney disease (CKD) has been low among affected patients, particularly the older ones. However, whether such awareness is synonymous with the presence of laboratory-diagnosed CKD among older adults is currently unclear.

Methods: We enrolled community-dwelling old adults (≥ 65 years) who received health examinations between 2013 and 2016 from a regional metropolitan hospital. Read More

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http://dx.doi.org/10.1159/000496002DOI Listing
February 2019
2 Reads