58,660 results match your criteria Anemia in Elderly Persons


A Single-Center Experience with Minimally Invasive Transgastric ERCP in Patients with Previous Gastric Bypass: Lessons Learned and Technical Considerations.

Am Surg 2020 Apr;86(4):300-307

As bariatric surgery increases, there is a growing population of patients with biliary obstruction and anatomy which precludes transoral access through endoscopic retrograde cholangiopancreatography (ERCP). Minimally invasive transgastric ERCP (TG-ERCP) offers a feasible alternative for the treatment. A retrospective review was performed of all patients who underwent laparoscopic or robotic-assisted TG-ERCP between 2010 and 2017. Read More

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CANOMAD syndrome with respiratory failure.

Ideggyogy Sz 2020 Mar;73(3-4):141-144

Department of Neurology, University of Szeged, Szeged.

CANOMAD (chronic ataxic neuropathy, ophthalmoplegia, M-protein agglutination, disialosyl antibodies) syndrome is a rare polyneuropathy. IgM paraproteins react with ganglioside-containing disialylated epitopes resulting in dorsal root ganglionopathy and B-lymphocyte infiltration of cranial and peripheral nerves. Clinical features include ataxia, slight muscle weakness, areflexia, sensory- and cranial nerve symptoms. Read More

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http://dx.doi.org/10.18071/isz.73.0141DOI Listing

Associations of maternal hyperglycemia in the second and third trimesters of pregnancy with prematurity.

Medicine (Baltimore) 2020 Apr;99(17):e19663

Department of Endocrinology, Beijing Tongren Hospital.

Hyperglycemia in pregnancy (HIP) is related to adverse pregnancy outcomes. However, women with hyperglycemia in the second and third trimester of pregnancy (HISTTP) were not been observed. We aim to reveal associations between HISTTP and prematurity. Read More

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http://dx.doi.org/10.1097/MD.0000000000019663DOI Listing

Prevalence of priapism in individuals with sickle cell disease and implications on male sexual function.

Einstein (Sao Paulo) 2020 22;18:eAO5070. Epub 2020 Apr 22.

Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil.

Objective: To evaluate epidemiological aspects of priapism in patients with sickle cell disease, and these aspects impact on adult sexual function.

Methods: This was a cross-sectional study including individuals with sickle cell disease who were evaluated at a reference center for sickle cell. Participants completed a structured questionnaire about their sociodemographic characteristics and priapism events. Read More

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http://dx.doi.org/10.31744/einstein_journal/2020AO5070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186002PMC

Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease.

N Engl J Med 2020 05 22;382(19):1800-1810. Epub 2020 Apr 22.

From the Department of Medicine I, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg (R.Z.), the Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck (N.B.), the Department of Hematology and Oncology, University of Leipzig, Leipzig (D.N.), and the Department of Hematology, Oncology, and Pneumology, University Medical Center Mainz, Mainz (E.M.W.) - all in Germany; the Department of Bone Marrow Transplantation, Royal Brisbane and Women's Hospital, Brisbane, QLD (J.B.), and the Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC (J.S.) - all in Australia; Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Sorbonne and INSERM Unité Mixte de Recherche (UMR) 938 (M.M.), and AP-HP, Hématologie-Transplantation, Hôpital St. Louis, Université de Paris and INSERM UMR 976 (G.S.), Paris, and Novartis Pharma, Rueil-Malmaison (B.M.) - all in France; the Cancer Immunotherapy and Immunobiology Research Center, Hadassah University Hospital, Jerusalem (R.O.), and the Hematology Institute and Bone Marrow Transplantation, Clinical Research Institute at Rambam, Rambam Health Care Campus, Haifa (T.Z.) - both in Israel; Novartis Pharmaceuticals, East Hanover, NJ (J.X., K.K.G.); and Novartis Pharma, Basel, Switzerland (C.W.).

Background: Acute graft-versus-host disease (GVHD) remains a major limitation of allogeneic stem-cell transplantation; not all patients have a response to standard glucocorticoid treatment. In a phase 2 trial, ruxolitinib, a selective Janus kinase (JAK1 and JAK2) inhibitor, showed potential efficacy in patients with glucocorticoid-refractory acute GVHD.

Methods: We conducted a multicenter, randomized, open-label, phase 3 trial comparing the efficacy and safety of oral ruxolitinib (10 mg twice daily) with the investigator's choice of therapy from a list of nine commonly used options (control) in patients 12 years of age or older who had glucocorticoid-refractory acute GVHD after allogeneic stem-cell transplantation. Read More

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http://dx.doi.org/10.1056/NEJMoa1917635DOI Listing

Burden of fatigue among adults living with HIV/AIDS attending antiretroviral therapy in Ethiopia.

BMC Infect Dis 2020 Apr 15;20(1):280. Epub 2020 Apr 15.

Department of Physiotherapy, School of Medicine, College of Health Sciences and Ayder Comprehensive Specialized Hospital, Mekelle University, P.O.Box: 1871, Mekelle, Ethiopia.

Background: Fatigue is one of the most common and devastating Human Immuno-deficiency Virus (HIV) - related symptoms, with a varying prevalence in different study areas. In Ethiopia, there is a paucity of information on the magnitude and factors associated with fatigue among HIV/Acquired Immune Deficiency Syndrome (AIDS) patients. This may lead to under-diagnosis and eventually under-management of the symptom. Read More

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http://dx.doi.org/10.1186/s12879-020-05008-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161178PMC

HEPATITIS C TREATMENT OF RENAL TRANSPLANT AND CHRONIC KIDNEY DISEASE PATIENTS: EFFICACY AND SAFETY OF DIRECT-ACTING ANTIVIRAL REGIMENS CONTAINING SOFOSBUVIR.

Arq Gastroenterol 2020 Jan-Mar;57(1):45-49

Universidade Federal de São Paulo (UNIFESP), Disciplina de Gastroenterologia, São Paulo, SP, Brasil.

Background: Direct-acting antivirals have revolutionized hepatitis C treatment, also for patients with chronic kidney disease (CKD), but some controversy exists regarding the use of sofosbuvir (SOF) in patients with glomerular filtration rate (GFR) <30 mL/min.

Objective: To evaluate the efficacy and safety of these regimens for hepatitis C treatment of patients with CKD and after renal transplantation, as well as the impact of SOF on renal function in non-dialysis patients.

Methods: All patients with hepatitis C and CKD or renal transplant treated with direct-acting antivirals at a referral center in Brazil between January 2016 and August 2017 were included. Read More

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http://dx.doi.org/10.1590/S0004-2803.202000000-09DOI Listing

Risk factors of perioperative blood transfusion in elderly patients with femoral intertrochanteric fracture.

Medicine (Baltimore) 2020 Apr;99(15):e19726

This study aimed to discuss the risk factors of perioperative blood transfusion after the application of proximal femoral nail antirotation (PFNA) in the treatment of elderly patients with femoral intertrochanteric fracture (FIF). Moreover, this study also aimed to analyze the causes of perioperative blood transfusion and provide guidance for clinical treatment.Records of elderly patients with FIF who were treated with PFNA in our hospital from September 2014 to May 2017 were reviewed. Read More

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http://dx.doi.org/10.1097/MD.0000000000019726DOI Listing

A study of concurrent chemoradiotherapy with weekly docetaxel and cisplatin for advanced esophageal squamous cell carcinoma with T4 and/or M1 lymph node metastasis or locoregional recurrence.

Radiat Oncol 2020 Apr 8;15(1):75. Epub 2020 Apr 8.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.

Background: The improvement of survival outcomes and the reduction of toxicities for esophageal squamous cell carcinoma (SCC) are still needed. We conducted a pilot study of concurrent chemoradiotherapy with weekly docetaxel and cisplatin for the treatment of esophageal SCC with T4 and/or M1 lymph node metastasis (LNM) or locoregional recurrence.

Methods: Fifty-four patients with advanced thoracic esophageal SCC having a stage T4 tumor or M1 LNM and/or locoregional recurrence were enrolled. Read More

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http://dx.doi.org/10.1186/s13014-020-01518-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140386PMC

Adjusting plasma or serum zinc concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.

Am J Clin Nutr 2020 04;111(4):927-937

Children's Hospital Oakland Research Institute, Oakland, CA, USA.

Background: The accurate estimation of zinc deficiency at the population level is important, as it guides the design, targeting, and evaluation of nutrition interventions. Plasma or serum zinc concentration (PZC) is recommended to estimate zinc nutritional status; however, concentrations may decrease in the presence of inflammation.

Objectives: We aimed to assess the relation between PZC and inflammation in preschool children (PSC; 6-59 mo) and nonpregnant women of reproductive age (WRA; 15-49 y), and to compare different inflammation adjustment approaches, if adjustment is warranted. Read More

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http://dx.doi.org/10.1093/ajcn/nqz304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138668PMC

Interpretation of vitamin B-12 and folate concentrations in population-based surveys does not require adjustment for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.

Am J Clin Nutr 2020 04;111(4):919-926

Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Vitamin B-12 and folate deficiencies in women and children have important public health implications. However, the evidence is conflicting and limited on whether the influence of inflammation on biomarker concentrations may be sufficiently and consistently influenced by inflammation to require adjustment for interpreting concentrations or estimating population prevalence of deficiencies.

Objective: We examined correlations between concentrations of the inflammation biomarkers C-reactive protein (CRP) and α1-acid glycoprotein (AGP) and serum vitamin B-12 and serum and RBC folate among nonpregnant women of reproductive age (WRA; 15-49 yr) and preschool children (PSC; 6-59 mo). Read More

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http://dx.doi.org/10.1093/ajcn/nqz303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138687PMC

Continuous lenalidomide treatment after bortezomib-melphalan-prednisolone therapy for newly diagnosed multiple myeloma.

Ann Hematol 2020 May 4;99(5):1063-1072. Epub 2020 Apr 4.

Higashi Nagoya National Hospital, Nagoya, Japan.

These are the results of phase II study of bortezomib-melphalan-prednisolone (VMP) induction therapy followed by lenalidomide-dexamethasone (Rd) consolidation and lenalidomide maintenance in transplant-ineligible patients with newly diagnosed multiple myeloma (NDMM). The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), overall response rates (ORRs), and safety. Read More

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http://dx.doi.org/10.1007/s00277-020-03988-6DOI Listing

[Transfusion trend in total hip arthroplasty following the implementation of a Patient Blood Management protocol.]

Rev Fac Cien Med Univ Nac Cordoba 2020 03 12;77(1):39-44. Epub 2020 Mar 12.

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Introduction: Total hip arthroplasty is a successful and safe surgical procedure, but it involves an associated blood loss. When this surgery is carried out on a scheduled basis, the implantation of a multimodal approach of Patient Blood Management (PBM) will significantly reduce transfusion needs.

Objective: To present the clinical-analytical results and the transfusion incidence after the implantation of a PBM protocol in those patients who are going to undergo prosthetic hip surgery. Read More

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http://dx.doi.org/10.31053/1853.0605.v77.n1.26515DOI Listing

A splenic 'cyst': histology confirmed splenic sarcoma.

Ann R Coll Surg Engl 2020 May 1;102(5):e105-e106. Epub 2020 Apr 1.

Hull Royal Infirmary, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.

Primary malignant fibrous histiocytoma, now classified as pleomorphic undifferentiated sarcoma, is the most common soft-tissue sarcoma in adult life. Primary splenic pleomorphic undifferentiated sarcoma is extremely rare and aggressive, and is associated with a poor prognosis; only 14 cases of splenic pleomorphic undifferentiated sarcoma have been documented in the English literature. We discuss a case of a 56-year-old woman with iron-deficiency anaemia, early satiety and left upper-quadrant pain, who was preoperatively diagnosed with a large splenic cyst following thorough investigation. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0035DOI Listing

Increased severity of anaemia is associated with 30-day complications following total joint replacement.

Bone Joint J 2020 Apr;102-B(4):485-494

Stavros Niarchos Foundation Complex Joint Reconstruction Center, Department of Orthopedic Surgery, Hospital for Special Surgery, New York, New York, USA.

Aims: The aim of this study was to determine the impact of the severity of anaemia on postoperative complications following total hip arthroplasty (THA) and total knee arthroplasty (TKA).

Methods: A retrospective cohort study was conducted using the American College of Surgeons National Quality Improvement Program (ACS-NSQIP) database. All patients who underwent primary TKA or THA between January 2012 and December 2017 were identified and stratified based upon hematocrit level. Read More

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http://dx.doi.org/10.1302/0301-620X.102B4.BJJ-2018-0991.R3DOI Listing

[Sequential development of mantle cell lymphoma following chronic lymphocytic leukemia].

Rinsho Ketsueki 2020 ;61(3):251-256

Department of Hematology, Kin-ikyo Chuo Hospital.

Richter syndrome (RS) is the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Most cases of diffuse large B-cell lymphoma variant of RS are clonally related to the original CLL. Here, we present a case of mantle cell lymphoma (MCL) that developed sequentially during the clinical course of CLL. Read More

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http://dx.doi.org/10.11406/rinketsu.61.251DOI Listing

Subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma (COLUMBA): a multicentre, open-label, non-inferiority, randomised, phase 3 trial.

Lancet Haematol 2020 May 23;7(5):e370-e380. Epub 2020 Mar 23.

Levine Cancer Institute-Atrium Health, Charlotte, NC, USA. Electronic address:

Background: Intravenous daratumumab for treatment of patients with multiple myeloma involves a lengthy infusion that affects quality of life, and infusion-related reactions are common. Subcutaneous daratumumab is thought to be easier to administer and to cause fewer administration-related reactions. In this study (COLUMBA), we tested the non-inferiority of subcutaneous daratumumab to intravenous daratumumab. Read More

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http://dx.doi.org/10.1016/S2352-3026(20)30070-3DOI Listing

Cisplatin Weekly Versus Every 3 Weeks Concurrently with Radiotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinomas: What Is the Best Dosing and Schedule?

Asian Pac J Cancer Prev 2020 Mar 1;21(3):799-807. Epub 2020 Mar 1.

Department of Clinical Oncology, Kasr Al-Einy Sschool of Medicine, Cairo University, Egypt.

Purpose: The aim of this prospective randomized study is to compare cisplatin at 2 dose levels given concurrently with intensity modulated radiation therapy (IMRT) in the treatment of locally advanced HNSCC. The main objectives were to evaluate treatment toxicities, loco-regional control, tumor response and patients compliance.

Methods: Patients were randomized into two groups that either received 30 mg/m2 cisplatin weekly (arm A) or 100 mg/m2 once every 3 weeks (arm B). Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.3.799DOI Listing

A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent β-Thalassemia.

N Engl J Med 2020 03;382(13):1219-1231

From the Department of Clinical Sciences and Community, University of Milan, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan (M.D.C.), Centro della Microcitemia e Anemie Congenite e del Dismetabolismo del Ferro, E.O. Ospedali Galliera, Genoa (G.L.F.), Ospedale Pediatrico Microcitemico A. Cao, Azienda Ospedaliera G. Brotzu, Cagliari (R.O.), Ematologia e Oncologia Pediatrica, Università della Campania L. Vanvitelli, Caserta (S.P.), and the Department of Clinical and Biological Sciences, University of Turin, Turin (A.P.) - all in Italy; Siriraj Hospital, Mahidol University, Bangkok (V.V.), and the Division of Hematology, Department of Internal Medicine, Chiang Mai University, Chiang Mai (A. Tantiworawit) - both in Thailand; the Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon (A.T.T.); St. George University Hospital for Active Treatment and Medical University of Plovdiv, Plovdiv (P. Georgiev), University Specialized Hospital for Active Treatment in Oncology, Sofia (P. Ganeva), and University Hospital St. Marina, Varna (L.G.) - all in Bulgaria; the Division of Medical Oncology and Hematology, Department of Medicine, University Health Network and Division of Hematology, Department of Medicine, University of Toronto, Toronto (K.H.M.K.); the Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, and Keck School of Medicine of the University of Southern California, Los Angeles (T.C.), and the University of California San Francisco Benioff Children's Hospital, Oakland (A. Lal) - all in California; the Thalassemia and Sickle Cell Center, Laiko General Hospital (E. Voskaridou), and the First Department of Pediatrics, National and Kapodistrian University of Athens (A. Kattamis), Athens, and the Adult Thalassemia Unit, Hippokration Hospital, Thessaloniki (E. Vlachaki) - all in Greece; Hospital Sultanah Bahiyah, Alor Setar (H.K.L.), Hospital Umum, Sarawak, Kuching (L.P.C.), the University of Malaya Medical Center, Kuala Lumpur (P.C.B.), and Hospital Sultanah Aminah, Johor Bahru (S.M.L.) - all in Malaysia; the Comprehensive Center of Thalassemia, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel (I.P.-K.); Farhat Hached University Hospital, Sousse (A. Khelif), and the National Bone Marrow Transplant Center and Faculty of Medicine, University of Tunis El Manar, Tunis (M.B.) - both in Tunisia; the Department of Pediatric Hematology and Oncology, Ege University Hospital, Izmir, Turkey (Y.A.); Royal Prince Alfred Hospital and the University of Sydney, Sydney (P.J.H.); National Taiwan University, Taipei, Taiwan (M.-Y. L.); the Department of Haematology, Whittington Health NHS Trust (F.S.), and the Department of Haematology, University College London and University College London Hospitals NHS Foundation Trust (J.P.) - all in London; St. Jude Children's Research Hospital, Memphis, TN (E.J.N.); Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago (A. Thompson); Celgene, Summit, NJ (A. Laadem, J. Zou, J. Zhang); Celgene, Boudry, Switzerland (J.K.S., D.M., T.Z.); Acceleron Pharma, Cambridge, MA (P.G.L., M.L.S.); and the Department of Hematology, Necker Hospital, Assistance Publique-Hôpitaux de Paris (O.H.), and Imagine Institute, INSERM Unité 1163, University of Paris (O.H.) - both in Paris.

Background: Patients with transfusion-dependent β-thalassemia need regular red-cell transfusions. Luspatercept, a recombinant fusion protein that binds to select transforming growth factor β superfamily ligands, may enhance erythroid maturation and reduce the transfusion burden (the total number of red-cell units transfused) in such patients.

Methods: In this randomized, double-blind, phase 3 trial, we assigned, in a 2:1 ratio, adults with transfusion-dependent β-thalassemia to receive best supportive care plus luspatercept (at a dose of 1. Read More

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http://dx.doi.org/10.1056/NEJMoa1910182DOI Listing
March 2020
55.873 Impact Factor

In Reply to Letter to the Editor Regarding "Perioperative Complications Associated with Severity of Anemia in Geriatric Patients Undergoing Spinal Procedures".

World Neurosurg 2020 04;136:425

Department of Neurosurgery, The George Washington University, Washington, DC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2020.01.104DOI Listing

Letter to the Editor Regarding "Perioperative Complications Associated with Severity of Anemia in Geriatric Patients Undergoing Spinal Procedures".

World Neurosurg 2020 04;136:424

Department of Cardiology, Muğla University, Faculty of Medicine, Muğla, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2020.01.046DOI Listing

Anemia risk factors among people living with HIV across the United States in the current treatment era: a clinical cohort study.

BMC Infect Dis 2020 Mar 20;20(1):238. Epub 2020 Mar 20.

Department of Medicine, University of Washington, 1959 NE Pacific Street, Health Sciences Building F-26, Box 357236, Seattle, WA, 98195, USA.

Background: Anemia is common among people living with HIV infection (PLWH) and is associated with adverse health outcomes. Information on risk factors for anemia incidence in the current antiretroviral therapy (ART) era is lacking.

Methods: Within a prospective clinical cohort of adult PLWH receiving care at eight sites across the United States between 1/2010-3/2018, Cox proportional hazards regression analyses were conducted among a) PLWH free of anemia at baseline and b) PLWH free of severe anemia at baseline to determine associations between time-updated patient characteristics and development of anemia (hemoglobin < 10 g/dL), or severe anemia (hemoglobin < 7. Read More

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http://dx.doi.org/10.1186/s12879-020-04958-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085166PMC

Low handgrip strength is closely associated with anemia among adults: A cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES).

PLoS One 2020 20;15(3):e0218058. Epub 2020 Mar 20.

Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Gangnam-gu, Seoul, Republic of Korea.

Background: Anemia, which is a major public health problem worldwide, represents a decline in the oxygenation function, and can therefore be related to low strength. However, hemoglobin cannot repair muscles directly, but is beneficial only in a supportive role. Previous studies on the relationship between handgrip strength and anemia have been controversial. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218058PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083305PMC

Analysis on plausible factors related to the prognosis of stage IV esophageal cancer.

Medicine (Baltimore) 2020 Mar;99(12):e18529

Department of Medical Oncology, Anqing Hospital Affiliated to Medical University of Anhui, Anqing, China.

To investigate factors related to poor prognosis of patients with stage IV esophageal cancer and to provide some bases on which proper therapeutic schemes could be formulated for stage IV esophageal cancer patients with performance status (PS) score between 0 and 2.Clinical data of 60 patients with stage IV esophageal cancer were retrospectively analyzed, and the relationships of clinical characteristics and therapeutic methods with patients' prognosis were explored. Univariate analysis on factors possibly affecting the prognosis of patients with stage IV esophageal cancer was performed using Log-rank test, and independent risk factors for the prognosis were estimated in multivariate Cox regression analysis through embracing variables which showed statistical significance in univariate analyses. Read More

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http://dx.doi.org/10.1097/MD.0000000000018529DOI Listing

[Comparison of short-term efficacy and perioperative safety between neoadjuvant therapy and total neoadjuvant therapy in patients with locally advanced rectal cancer].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Mar;23(3):274-280

Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

To compare the short-term efficacy and perioperative safety of neoadjuvant chemoradiotherapy (nCRT) with total neoadjuvant treatment (TNT) in patients with locally advanced rectal cancer (LARC). A retrospective cohort analysis was carried out. Inclusion criteria: (1) rectal adenocarcinoma confirmed by pathology with a distance from tumor inferior border to anal verge within 12 cm; (2) clinical stage cT3-4N0 or cT1-4N1-2 diagnosed by magnetic resonance imaging (MRI) or endorectal ultrasonography; (3) a single rectal tumor confirmed by colonoscopy; (4) patients suitable for chemoradiotherapy; (5) no previous history of other tumors. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20190819-00312DOI Listing

Prevalence of anemia among elderly persons residing in old age homes in national capital territory, Delhi, India.

Indian J Public Health 2019 Oct-Dec;63(4):288-292

Department of Community Medicine, Lady Hardinge Medical College, New Delhi, India.

Background: Anemia is a common morbidity in elderly persons (aged 60 years or above). In India, in recent years, the number of old age homes (OAHs) and the residents living in them has increased significantly.

Objective: The aim of this study was to estimate the prevalence of anemia among elderly persons living in OAHs. Read More

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http://dx.doi.org/10.4103/ijph.IJPH_412_18DOI Listing

[A Case in Which pCR Was Obtained by S-1 plus Oxaliplatin Therapy Administered as Neoadjuvant Chemotherapy for Advanced Gastric Cancer].

Gan To Kagaku Ryoho 2019 Dec;46(13):2030-2032

Dept. of Surgery, Fuchu Hospital.

A 78-year-old man presented with anemia, with a hemoglobin level of 6.7 g/dL, during follow-up for angina pectoris and paroxysmal atrial fibrillation. Upper gastrointestinal endoscopy revealed type 2 advanced gastric cancer(por), and abdominal computed tomography(CT)showed multiple lymph node metastases. Read More

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December 2019

[A Case of Gastric Large-Cell Neuroendocrine Carcinoma Combined with Adenocarcinoma in the Cecum].

Gan To Kagaku Ryoho 2019 Dec;46(13):1990-1992

Dept. of Surgery, Tokyo Metropolitan Hiroo Hospital.

A 74-year-old man with anemia visited our department. Esophagogastroduodenoscopy showed a type 2 lesion from the angulus to the antrum. Histopathological findings indicated gastric neuroendocrine carcinoma. Read More

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December 2019

[A Case of CR Achieved by Chemotherapy for Distant Metastatic Lymph Nodes after Surgery for HER2 Positive Early Gastric Cancer].

Gan To Kagaku Ryoho 2019 Dec;46(13):2592-2594

Dept. of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center.

The patient was a 72-year-old man who exhibited an abnormal shadow in the stomach in a series of medical check-ups of the upper gastrointestinal in August 20XX. It was diagnosed as gastric cancer(type 1)of the greater curvature of the MU region. Total gastrectomy, D2-11p dissection, and Roux-en-Y reconstruction were performed in October 20XX. Read More

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December 2019

[A Case of Laparoscopic Gastric Local Resection for Simultaneous Multiple Gastric GIST Discovered Owing to Gastrointestinal Bleeding].

Gan To Kagaku Ryoho 2019 Dec;46(13):2380-2382

Dept. of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine.

An 80-year-old woman with anemia presented to our hospital. Upper gastrointestinal endoscopy revealed a 4 cm submucosal tumor(SMT)with a delle and 2 cm SMT in the upper part of the stomach. CT revealed sustained enhancement of both tumors. Read More

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December 2019

[Two Cases of Advanced Gastric Cancer with Simultaneous Liver Metastasis with Long-Term Recurrence-Free Survival].

Gan To Kagaku Ryoho 2019 Dec;46(13):2333-2335

Dept. of Surgery, Kishiwada Tokushukai Hospital.

We report 2 cases of postoperative long-term survival of gastric cancer with synchronous liver metastasis. Case 1 was a 65- year-old man. Examination for anemia revealed advanced type 5 cancer in the antrum and suspected invasion of the transverse colon. Read More

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December 2019

[A Case of Mesenteric Hematoma Caused by Abdominal Metastasis of Small Cell Lung Carcinoma].

Gan To Kagaku Ryoho 2019 Dec;46(13):2164-2166

Dept. of Surgery, Osaka Police Hospital.

Chemoradiation was performed at Osaka Police Hospital's department of respiratory medicine on a 70-year-old male with small cell lung carcinoma(cT4N3M0, cStage ⅢC). Subsequent to secondary chemotherapy for multiple bone metastases that had been observed, he received care to control the disease. He arrived at the hospital complaining of epigastric pain. Read More

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December 2019

[A Case Report of Gastrointestinal Bleeding with Difficulty in Diagnosis].

Gan To Kagaku Ryoho 2019 Dec;46(13):2134-2136

Dept. of Surgery, Saiseikai Yahata General Hospital.

The authors report a case involving a 55-year-old female patient who presented with melena and anemia 8 years ago. Esophagogastroduodenoscopy, colonoscopy, and CT did not reveal any sign of lesions except multiple uterine myoma. On reevaluation after the onset of melena, we did not find any lesions. Read More

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December 2019

[Hemoglobinuria in children hospitalized in Ouagadougou: short term inpatient care and prognosis].

Pan Afr Med J 2019 26;34:165. Epub 2019 Nov 26.

Service de Pédiatrie Médicale, Centre Hospitalier Universitaire Pédiatrique Charles-de-Gaulle, Ouagadougou, Burkina Faso.

Introduction: The purpose of this study was to analyze the epidemiological, diagnostic, therapeutic and evolutionary features of hemoglobinuria in children hospitalized in the Pediatric University Hospital Charles de Gaulle, Ouagadougou.

Methods: We conducted a cross-sectional descriptive study over the period 01 July-31 December 2014. All children aged 0-15 years hospitalized in the Department of Medical Pediatrics of the Pediatric University Hospital Charles de Gaulle and diagnosed with macroscopic hemoglobinuria during the study period were enrolled. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.165.14729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046116PMC

Audit of Childhood Death in a Tertiary Care Center in Niger Delta Region of Nigeria.

West Afr J Med 2020 Apr-Jun;37(2):113-117

Health Information Management Department, Delta State University Teaching Hospital, Oghara, Delta State,Nigeria.

Background: Childhood mortality is a serious public health concern. Periodic assessment of its trend is important in evaluating the pattern and planning intervention strategies.

Objective: The study aimed at evaluating the childhood mortality (<18 years) in Delta State University Teaching Hospital, Nigeria. Read More

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[Successful treatment of pure red cell aplasia complicated by multicentric Castleman disease with prednisolone].

Rinsho Ketsueki 2020 ;61(2):122-127

Department of Hematology, Yokohama City Minato Red Cross Hospital.

A 76-year-old man presented with shortness of breath and the laboratory tests suggested anemia and reticulocytopenia. CBC showed only anemia, and the bone marrow aspiration smear demonstrated absence of erythroid hematopoietic cells. Consequently, pure red cell aplasia (PRCA) was diagnosed. Read More

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http://dx.doi.org/10.11406/rinketsu.61.122DOI Listing

High levels of proinflammatory cytokines IL-6 and IL-8 are associated with a poor clinical outcome in sickle cell anemia.

Ann Hematol 2020 May 5;99(5):947-953. Epub 2020 Mar 5.

Department of Clinical Pathology, School of Medical Sciences, State University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.

Sickle cell anemia (SCA) pathophysiology is characterized by the activation of sickle red blood cells, reticulocytes, leukocytes, platelets, and endothelial cells, and with the expression of several inflammatory molecules. Therefore, it is conceivable that variations in levels of proinflammatory cytokines may act as a signaling of differential clinical course in SCA. Here, we evaluated the clinical impact of proinflammatory cytokines interleukin 1-β (IL-1β), interleukin 6 (IL-6), and interleukin 8 (IL-8) in 79 patients with SCA, followed in a single reference center from northeastern Brazil. Read More

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http://dx.doi.org/10.1007/s00277-020-03978-8DOI Listing

[Clinical and laboratory analysis of 17 patients with γδT-cell large granular lymphocyte leukemia].

Zhonghua Xue Ye Xue Za Zhi 2020 Feb;41(2):112-116

Department of Therapeutic Center of Anemia, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, National Clinical Research Center for Blood Diseases, Tianjin 300020, China.

To compare the difference of the clinical and laboratory characteristics between γδ T-cell large granular lymphocyte leukemia (γδT-LGLL) and αβ T-cell large granular lymphocyte leukemia (αβT-LGLL) . The clinical and laboratory characteristics of 17 patients with γδT-LGLL and 91 patients with αβT-LGLL in the department of therapeutic center of anemia of enrolled in our hospital from January 2009 to January 2019 were retrospectively analyzed. The median age of the 17 patients with γδT-LGLL was 54 years (range, 25-73 years) , the most common presenting symptom was anemia. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.02.005DOI Listing
February 2020

[Clinical features of 9 cases of Brucella endocarditis].

Zhonghua Xin Xue Guan Bing Za Zhi 2020 Feb;48(2):142-147

Infectious Diseases Diagnostic, Therapeutic and Research Centre, Beijing Ditan Hospital, Capital Medical University, Synergetic and Innovative Centre for Prevention and Treatment of Key Infectious Diseases, Capital Medical University National Clinical Key Department of Infectious Diseases, Beijing 100015, China.

To explore the clinical characteristics of patients with Brucella endocarditis. The clinical data of 9 patients with Brucella endocarditis admitted to Beijing Ditan Hospital from October 2008 to August 2018 were retrospectively analyzed. Through the electronic medical record system of the hospital. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3758.2020.02.010DOI Listing
February 2020

[Predictive values of routine blood test results for iron deficiency in children].

Zhonghua Er Ke Za Zhi 2020 Mar;58(3):201-205

Department of Pediatric Health Care, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310003, China.

To explore the predictive values of routine blood test results for iron deficiency (ID) screening in children. Routine blood test results and serum ferritin (SF) levels from 1 443 healthy children (862 boys, 581 girls) aged 6 months to 18 years, who were seen for well-child visits between June 2017 and May 2019 in Children's Hospital, Zhejiang University School of Medicine, were retrospectively analyzed. ID was defined as SF<20 μg/L, iron deficiency anemia (IDA) as ID with anemia (hemoglobin(Hb)<110 g/L at 6 months-5 years of age, Hb<120 g/L at 6-18 years of age), non-anemia ID as ID without anemia, non-ID anemia as SF≥20 μg/L with anemia, and healthy control subjects as those with SF≥20 μg/L but without anemia. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2020.03.008DOI Listing

Evaluation of adult celiac disease from a tertiary reference center: a retrospective analysis.

Rev Assoc Med Bras (1992) 2020 27;66(1):55-60. Epub 2020 Feb 27.

. Tepecik Education and Research Hospital, Department of Internal Medicine, Yenisehir-Izmir/Turkey.

Objective: It has been observed that celiac disease (CD) is not restricted to a single type characterized by diarrhea but also has atypical, asymptomatic (silent), and latent forms. The prevalence of this autoimmune disease, which affects approximately 1% of the world, is estimated to be around 3%, including atypical and asymptomatic cases. In our study, we aimed to evaluate adult celiac patients. Read More

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http://dx.doi.org/10.1590/1806-9282.66.1.55DOI Listing

Effect of intravenous iron replacement therapy on exercise capacity in iron deficient anemic patients after cardiac surgery.

Monaldi Arch Chest Dis 2020 Mar 3;90(1). Epub 2020 Mar 3.

Cardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, Palermo.

Iron deficiency (ID) is recognized as an important comorbidity in patients undergoing cardiac surgery; however, it still remains under-diagnosed and under-treated in clinical practice. This study aims at comparing efficacy and the effects on exercise capacity of intravenous ferric carboxymaltose (FCM) versus ferric gluconate (FG) in patients with ID anemia (IDA) resulting from cardiac surgery. We retrospectively analyzed data from our records of in-hospital patients with IDA after cardiac surgery undergoing cardiac rehabilitation. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1196DOI Listing

Molecular epidemiology and hematologic characterization of δβ-thalassemia and hereditary persistence of fetal hemoglobin in 125,661 families of greater Guangzhou area, the metropolis of southern China.

BMC Med Genet 2020 02 28;21(1):43. Epub 2020 Feb 28.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China.

Background: Individuals with δβ-thalassemia/HPFH and β-thalassemia usually present with intermedia or thalassemia major. No large-scale survey on HPFH/δβ-thalassemia in southern China has been reported to date. The purpose of this study was to examine the molecular epidemiology and hematologic characteristics of these disorders in Guangzhou, the largest city in Southern China, to offer advice for thalassemia screening programs and genetic counseling. Read More

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http://dx.doi.org/10.1186/s12881-020-0981-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049201PMC
February 2020

Severe anaemia complicating HIV in Malawi; Multiple co-existing aetiologies are associated with high mortality.

PLoS One 2020 25;15(2):e0218695. Epub 2020 Feb 25.

Global child health group, Emma Children's Hospital, University Medical Centres Amsterdam, location Academic Medical Centre, University of Amsterdam, The Netherlands.

Background: Severe anaemia is a major cause of morbidity and mortality in HIV-infected adults living in resource-limited countries. Comprehensive data on the aetiology are lacking but are needed to improve outcomes.

Methods: HIV-infected adults with severe (haemoglobin ≤70g/l) or very severe anaemia (haemoglobin ≤ 50 g/l) were recruited at Queen Elizabeth Central Hospital, Blantyre, Malawi. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218695PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041863PMC
April 2020
3.234 Impact Factor

Less 'reds' more 'blues': hemoglobin level and depression in non-transfusion-dependent thalassemia.

Ann Hematol 2020 Apr 21;99(4):903-904. Epub 2020 Feb 21.

Department of Internal Medicine, American University of Beirut Medical Center, Beirut, 11072020, Lebanon.

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http://dx.doi.org/10.1007/s00277-020-03958-yDOI Listing

Postoperative anaemia might be a risk factor for postoperative delirium and prolonged hospital stay: A secondary analysis of a prospective cohort study.

PLoS One 2020 21;15(2):e0229325. Epub 2020 Feb 21.

Department of Anesthesiology and Operative Intensive Care Medicine, Charité Campus Mitte and Campus Virchow Klinikum, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Postoperative anaemia is a frequent surgical complication and in contrast to preoperative anaemia has not been validated in relation to mortality, morbidity and its associated health economic effect. Postoperative anaemia can predispose postoperative delirium through impairment of cerebral oxygenation. The aim of this secondary analysis is to investigate the association of postoperative anaemia in accordance with the sex specific World Health Organization definition of anaemia to postoperative delirium and its impact on the duration of hospital stay. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229325PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034819PMC

An experimental erythrocyte rigidity index (Ri) and its correlations with Transcranial Doppler velocities (TAMMV), Gosling Pulsatility Index PI, hematocrit, hemoglobin concentration and red cell distribution width (RDW).

PLoS One 2020 21;15(2):e0229105. Epub 2020 Feb 21.

Rheology Laboratory, Materials Engineering Post-Graduation Program REDEMAT-UEMG/DESP-ED, State University of Minas Gerais, Belo Horizonte, Minas Gerais, Brasil.

Brain artery velocities (Time-Averaged Maximum Mean Velocity, TAMMV) by Transcranial Doppler (TCD), hematocrit, hemoglobin, Red blood cell (RBC) Distribution Width (RDW) and RBC rigidity index (Ri), when reported together with their correlations, provide a accurate and useful diagnostic picture than blood viscosity measurements alone. Additionally, our study included a sixth parameter provided by TCD, the Gosling Pulsatility Index PI, which is an indicator of CBF (Cerebral Blood Flow) resistance. All these parameters are routine in Hematology except for values of Ri. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229105PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034921PMC

[Exploration on total parathyroidectomy for secondary hyperparathyroidism].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;55(2):98-103

Department of Otolaryngology Head and Neck Surgery, Beijing Civil Aviation General Hospital, Peking University Civil Aviation School of Clinical Medicine, Beijing 100123, China.

To evaluate the clinical significance of dissection parathyroidectomy for secondary hyperparathyroidism (SHPT) in patients with renal disease on maintenance dialysis. We retrospectively reviewed 195 patients with SHPT treated in the Department of Otolaryngology & Head and Neck Surgery of Beijing Civil Aviation General Hospital between September 2009 and September 2017, including 92 males and 103 females, aged from 23 to 77 years old. There were 167 patients by operated firstly and 28 patients by operated secondly for persistent or recurrent SHPT after operation. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2020.02.004DOI Listing
February 2020

[The 475th case: renal tubular acidosis, renal failure, anemia, and lactic acidosis].

Authors:
G Chen D Wu M X Li

Zhonghua Nei Ke Za Zhi 2020 Feb;59(2):165-168

Department of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

A 47-year-old female patient presented nausea and vomiting for half a year and elevated serum creatinine for 3 days. Proximal renal tubular acidosis (RTA) complicated with anemiawas confirmed after admission. Secondary factors, such as autoimmune disease, drugs, poison, monoclonal gammopathy, were excluded. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2020.02.015DOI Listing
February 2020

[The 474th case: anemia, ostealgia, proteinuria].

Zhonghua Nei Ke Za Zhi 2020 Feb;59(2):161-164

Department of Hematology, Multiple Myeloma Medical Center of Beijing, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China.

A 49-year-old woman was admitted to hospital with intermittent dizziness and fatigue for 7 years. The symptoms were aggravated and accompanied by bone pain for more than 4 months. She was referred to our hospital. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2020.02.014DOI Listing
February 2020