55,292 results match your criteria Anemia in Elderly Persons


Plerixafor for the Treatment of WHIM Syndrome.

N Engl J Med 2019 01;380(2):163-170

From the Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases (D.H.M., D.V., E.C., Q.L., P.M.M.), the Laboratories of Cellular Oncology (D.V.P., C.B.B.) and Pathology (S.P.), National Cancer Institute, the Department of Laboratory Medicine, Clinical Center (K.R.C.), the National Institute of Dental and Craniofacial Research (P.J.G.), and the National Institute on Deafness and Other Communication Disorders (D.A.B.), National Institutes of Health, and Kozloff and Trout MDs (H.H.T.), Bethesda, MD; the Infectious Diseases Unit and Primary Immunodeficiencies Unit, Hospital Dona Estefânia, Pediatric University Hospital (J.F.N.), and Centro de Imunodeficiências Primárias, Academic Medical Center of Lisbon (S.L.S.), Lisbon, Portugal; and the University of Chicago Medical Center, Chicago (E.A.B., E.M.L.).

WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis), a primary immunodeficiency disorder involving panleukopenia, is caused by autosomal dominant gain-of-function mutations in CXC chemokine receptor 4 (CXCR4). Myelokathexis is neutropenia caused by neutrophil retention in bone marrow. Patients with WHIM syndrome are often treated with granulocyte colony-stimulating factor (G-CSF), which can increase neutrophil counts but does not affect cytopenias other than neutropenia. Read More

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http://dx.doi.org/10.1056/NEJMoa1808575DOI Listing
January 2019

Novel EZH2 mutation in a patient with secondary B-cell acute lymphocytic leukemia after deletion 5q myelodysplastic syndrome treated with lenalidomide: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e14011

FUNDALEU, Buenos Aires, Argentina.

Rationale: The gene deletion (5)(q22q35) is reported in 10-20% of myelodysplastic syndrome (MDS) cases and is associated with response to lenalidomide and favorable prognosis. The authors report here a clinical case of MDS transformation to B-cell acute lymphocytic leukemia (B-ALL) with an associated accrual of an additional mutation following treatment with lenalidomide.

Patient Concerns: A 69-year-old man presented with progressive anemia, normal white blood cell count, and thrombocytopenia consistent with MDS. Read More

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http://dx.doi.org/10.1097/MD.0000000000014011DOI Listing
January 2019
1 Read
5.723 Impact Factor

Invasive molecular prenatal diagnosis of alpha and beta thalassemia among Hakka pregnant women.

Medicine (Baltimore) 2018 Dec;97(52):e13557

Clinical Core Laboratory.

This study is a retrospective analysis of the prenatal genetic diagnosis results of fetuses with high risk of major thalassemia to provide information for clinical genetic counseling and to better control the birth of major thalassemia child in Hakka population. Totally, 467 fetuses in at-risk pregnancies were collected from Meizhou people's hospital from January 2014 to December 2017. Genomic DNAs were extracted from peripheral blood of the couples and villus, amniotic fluid or cord blood of the fetuses. Read More

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http://dx.doi.org/10.1097/MD.0000000000013557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314693PMC
December 2018
1 Read

Lower Esophageal Sphincter-preserving Anastomosis Is an Acceptable Reconstruction Method Following Laparoscopy-assisted Proximal Gastrectomy.

Anticancer Res 2019 Jan;39(1):425-430

Department of Surgery; Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Background/aims: Our study aimed to compared 3-year results following laparoscopy-assisted proximal gastrectomy (LAPG)-double tract anastomosis (DTA) and lower esophageal sphincter-preserving LAPG (LES-LAPG).

Patients And Methods: Nine patients who underwent LES-LAPG and 23 LAPG-DTA were compared regarding 3-year follow-up complications, the anemia-related parameter and albumin levels.

Results: During the 3-year follow-up period, no patient (0%) in the LES-LAPG and six patients (6/23, 26. Read More

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http://dx.doi.org/10.21873/anticanres.13129DOI Listing
January 2019

Parvovirus B19 Infection.

N Engl J Med 2018 Dec;379(24):2361

Universitätsklinikum Carl Gustav Carus, Dresden, Germany

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http://dx.doi.org/10.1056/NEJMicm1807156DOI Listing
December 2018

Vanishing spleen syndrome post right partial nephrectomy in a sicklemic patient.

Pan Afr Med J 2018 16;30:211. Epub 2018 Jul 16.

Division of Urology, Harlem Hospital Center, Columbia University, New York, NY, USA.

Splenic infarction after contralateral laparoscopic renal surgery has not, to our knowledge, been reported. The spleen is the most affected organ in sickle cell disease and the mechanism of auto infarction is thought to result from the crystallization of abnormal hemoglobin during periods of hypoxia or acidosis resulting in parenchymal ischemia and ultimately tissue necrosis. We report a case of 45 year old female with sickle cell disease who had an unremarkable spleen at the time of a laparoscopic right partial nephrectomy and was subsequently found to have marked diminution in her splenic volume. Read More

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http://www.panafrican-med-journal.com/content/article/30/211
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http://dx.doi.org/10.11604/pamj.2018.30.211.15454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294983PMC
January 2019
3 Reads

Long-term safety and efficacy of deferasirox in patients with myelodysplastic syndrome, aplastic anemia and other rare anemia in Taiwan.

Hematology 2019 Dec;24(1):247-254

k Department of Internal Medicine , Chung Shan Medical University Hospital , Taichung , Taiwan.

Objective: Patients with myelodysplastic syndromes (MDS), aplastic anemia (AA) or other rare anemia require chronic blood transfusions which can lead to iron overload and subsequent excess iron-mediated complications. Intensive iron chelation with deferasirox could remove excess iron and can alleviate these events; however, the long-term safety and efficacy in Chinese population are not clearly characterized. This study examined the long-term efficacy and safety of deferasirox in a real-world setting in Taiwan. Read More

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http://dx.doi.org/10.1080/16078454.2018.1557860DOI Listing
December 2019
4 Reads

Anemia secondary to the use of sodium valproate for preventing postoperative seizures in a 79-year-old man: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13626

Department of Geriatrics.

Rationale: Sodium valproate is a widely used antiepileptic drug and also used to prevent postoperative seizures in neurosurgery. Anemia caused by sodium valproate is occasionally reported and most are from pediatric patients.

Patient Concerns: We present the case of a 79-year-old man who developed anemia in the setting of a short-term sodium valproate therapy for the prevention of postoperative seizures. Read More

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http://dx.doi.org/10.1097/MD.0000000000013626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320182PMC
December 2018
1 Read

Association between Hemoglobin and Hemoglobin A: A Data-Driven Analysis of Health Checkup Data in Japan.

J Clin Med 2018 Dec 12;7(12). Epub 2018 Dec 12.

Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto 606-8501, Japan.

Background: Interpretation of hemoglobin A (HbA) levels may be confounded by spurious results in anemic persons, but its degree is not well-established.

Methods: We used an employer-based health insurance database, containing health checkup data and medical claims data; both were linked via a unique identifier of each beneficiary. This study included persons aged 18⁻75 years who participated in health checkups, with a confirmed or suspected diagnosis of diabetes. Read More

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http://dx.doi.org/10.3390/jcm7120539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306903PMC
December 2018

Minimally invasive surgery for inflammatory myofibroblastic tumor of the urinary bladder: Three case reports.

Medicine (Baltimore) 2018 Dec;97(49):e13474

Department of Urology, Institute of Urology, West China Hospital, Sichuan University.

Rationale: Inflammatory myofibroblastic tumors of the urinary bladder (IMTUB) is exceptionally rare. Currently, no standardized treatment has been established for IMTUBs.

Patient Concerns: Herein we report three cases presenting with hematuria and anemia. Read More

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http://dx.doi.org/10.1097/MD.0000000000013474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310511PMC
December 2018

THE ONSET OF CLINICAL MANIFESTATIONS IN INFLAMMATORY BOWEL DISEASE PATIENTS.

Arq Gastroenterol 2018 Jul-Sep;55(3):290-295

Universidade do Estado da Bahia, Departamento de Ciências da Vida, Salvador, BA, Brasil.

Background: The diagnosis of inflammatory bowel disease is often delayed because of the lack of an ability to recognize its major clinical manifestations.

Objective: Our study aimed to describe the onset of clinical manifestations in inflammatory bowel disease patients.

Methods: A cross-sectional study. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-73DOI Listing
January 2019

IMPACT OF SMALL BOWEL CAPSULE ENDOSCOPY IN IRON DEFICIENCY ANEMIA: INFLUENCE OF PATIENT'SAGE ON DIAGNOSTIC YIELD.

Arq Gastroenterol 2018 Jul-Sep;55(3):242-246

Hospital Senhora da Oliveira, Departamento de Gastroenterologia, Guimarães, Portugal.

Background: Iron deficiency anemia remains one of the main indications to perform small bowel capsule endoscopy. Literature suggests that diagnostic yield is influenced by patient's age but with conflicting results regarding age cutoff.

Objective: We aimed to clarify the differences in diagnostic yield and incidence of specific findings according to age. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-61DOI Listing
January 2019

Efficacy of Enteral Access in Patients with Esophageal Squamous Cell Carcinoma Under Neoadjuvant Therapy.

Anticancer Res 2018 Dec;38(12):6939-6945

Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan, R.O.C.

Background: Enteral feeding tubes used to manage the nutritional status of esophageal cancer were evaluated regarding their effectiveness in patients receiving neoadjuvant therapy.

Patients And Methods: A retrospective study evaluating patients with esophageal squamous cell carcinoma undergoing neoadjuvant therapy between 2001 and 2014 was conducted at a medical center. Hospital patients' records for enteral access (EA) insertion and treatment outcomes were statistically analyzed. Read More

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http://dx.doi.org/10.21873/anticanres.13072DOI Listing
December 2018
1 Read

A Phase II Study of Tri-weekly Low-dose Nab-paclitaxel Chemotherapy for Patients with Advanced Gastric Cancer.

Anticancer Res 2018 Dec;38(12):6911-6917

Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Background/aim: Nanoparticle albumin-bound (nab)-paclitaxel has demonstrated antitumor activity against advanced gastric cancer. However, gastric cancer patients can be difficult to treat with the recommended dose because of the high incidence of adverse toxicities. The aim of this study was to evaluate the safety and effectiveness of low-dose nab-paclitaxel in a multicenter, single-arm, phase II study. Read More

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http://dx.doi.org/10.21873/anticanres.13068DOI Listing
December 2018
3 Reads

Approach to the treatment of the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a US hematologist and a geriatric hematologist.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):88-96

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245982PMC
November 2018
1 Read

Treatment approach for the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a European hematologist.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):83-87

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245965PMC
November 2018
7 Reads

Sero-prevalence of Helicobacter pylori CagA immunoglobulin G antibody, serum pepsinogens and haemoglobin levels in adults.

Sci Rep 2018 Dec 4;8(1):17616. Epub 2018 Dec 4.

Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel.

Associations observed of Helicobacter pylori infection with haemoglobin levels are inconsistent. We examined associations of H. pylori sero-prevalence and serum pepsinogens (PGs), as non-invasive markers of atrophic gastritis, with haemoglobin levels. Read More

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http://dx.doi.org/10.1038/s41598-018-35937-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279832PMC
December 2018
2 Reads

Smartphone app for non-invasive detection of anemia using only patient-sourced photos.

Nat Commun 2018 12 4;9(1):4924. Epub 2018 Dec 4.

The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Atlanta, GA, USA.

We introduce a paradigm of completely non-invasive, on-demand diagnostics that may replace common blood-based laboratory tests using only a smartphone app and photos. We initially targeted anemia, a blood condition characterized by low blood hemoglobin levels that afflicts >2 billion people. Our app estimates hemoglobin levels by analyzing color and metadata of fingernail bed smartphone photos and detects anemia (hemoglobin levels <12. Read More

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http://dx.doi.org/10.1038/s41467-018-07262-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279826PMC
December 2018

Primary squamous cell carcinoma of the endometrium in a woman of perimenopausal age: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13418

Department of Gynecology.

Rationale: Primary squamous cell carcinoma of the endometrium (PSCCE) is a rare entity, and only sporadic cases have been reported in the literature since the 1st report in 1892. This report describes a case of a perimenopausal woman with PSCCE.

Patient Concerns: A 47-year-old, human papilloma virus type 16-positive, perimenopausal woman was admitted to our hospital with irregular vaginal bleeding for 6 months and secondary anemia. Read More

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http://dx.doi.org/10.1097/MD.0000000000013418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283105PMC
November 2018
1 Read
5.723 Impact Factor

Prevalence and clinical significances of red cell alloimmunization and red cell bound immunoglobulin G in polytransfused patients with thalassemias.

Hematology 2019 Dec;24(1):208-214

a Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.

The study was to determine the prevalence and clinical significances of red blood cell (RBC)-bound IgG as detected by flow cytometry in polytransfused patients with thalassemias. Relationship of the presence of RBC-bound IgG with RBC alloimmunization was also evaluated. This study included 59 polytransfused patients with β-thalassemia disease. Read More

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http://dx.doi.org/10.1080/16078454.2018.1549818DOI Listing
December 2019
1 Read

Iron Deficiency Anaemia In Pakistan: Celiac Disease An Underlying Cause.

J Ayub Med Coll Abbottabad 2018 Jul-Sep;30(3):372-376

Nusrat Riaz College, Quetta-Pakistan.

Background: Iron deficiency anaemia (IDA) is common in Pakistani population and an important cause of morbidity. Celiac disease (CD) is an important contributor and its diagnosis is frequently missed especially if present in atypical/non-diarrhoeal form. Non-responders to iron replacement therapy typically raises suspicion of celiac disease as underlying cause. Read More

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January 2019
11 Reads

Management of disseminated intravascular coagulation in a patient with hepatic angiosarcoma: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13321

Hematology Division, Massachusetts General Hospital, Boston, MA.

Rationale: Hepatic angiosarcoma is a rare endothelial cell tumor that may lead to concurrent consumptive coagulopathies including disseminated intravascular coagulation (DIC). This report details a multifaceted approach to managing DIC in a patient with advanced-stage hepatic angiosarcoma, which continued to progress after a brief response to taxane-based chemotherapy.

Patient Concerns: A 55-year-old man with a recent history of hemorrhoids and hemarthroses presented with acute rectal bleeding. Read More

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http://dx.doi.org/10.1097/MD.0000000000013321DOI Listing
November 2018
13 Reads

[Emergency treatment of sickle cell diseases in the Blood Diseases Department at the Koutoukou Maga National Teaching Hospital, Cotonou, Benin].

Pan Afr Med J 2018 3;30:192. Epub 2018 Jul 3.

Service des Maladies du Sang, Centre National Hospitalier Universitaire Hubert Koutoukou Maga de Cotonou, Benin.

Introduction: Evolution of sickle cell disease is marked by the occurrence of acute complications, some of which are real emergencies that can give rise to life-threatening or functional cosequences. This study aims to evaluate the frequency and the evolution of emergency treatment of sickle cell disease in the Blood Diseases Department at the Koutoukou Maga National Teaching Hospital, Cotonou.

Methods: We conducted a retrospective and descriptive study of all patients hospitalized for emergency treatment of sickle cell disease from January 2014 to December 2015. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.192.15931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235509PMC
December 2018
2 Reads

Prevalence and risk factors of anemia among children aged 6-23 months in Huaihua, Hunan Province.

BMC Public Health 2018 Nov 19;18(1):1267. Epub 2018 Nov 19.

Huaihua Maternal and Child Health Care Hospital, Huaihua, China.

Background: Anemia is one of the most common diseases of childhood and is a health problem globally, particularly in developing counties and in children less than 2 years of age. Anemia during childhood has short- and long-term effects on health. However, few studies have investigated the prevalence of anemia among children in Huaihua. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-018-6207-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245853PMC
November 2018
7 Reads

Association of preoperative anaemia with postoperative morbidity and mortality: an observational cohort study in low-, middle-, and high-income countries.

Br J Anaesth 2018 Dec 25;121(6):1227-1235. Epub 2018 Oct 25.

Critical Care and Perioperative Medicine Research Group, William Harvey Research Institute, Queen Mary University of London, London, UK. Electronic address:

Background: Anaemia is associated with poor postoperative outcomes, but few studies have described the impact of preoperative anaemia in low- and middle- (LMICs), and high-income countries (HICs).

Methods: This was a planned analysis of data collected during an international 7 day cohort study of adults undergoing elective inpatient surgery. The primary outcome was in-hospital death, and the secondary outcomes were in-hospital complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912183074
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http://dx.doi.org/10.1016/j.bja.2018.08.026DOI Listing
December 2018
5 Reads

Brief topical sodium nitrite and its impact on the quality of life in patients with sickle leg ulcers.

Medicine (Baltimore) 2018 Nov;97(46):e12614

Division of Hematology, Department of Oncology, Montefiore Medical Center, Bronx, NY, USA.

Cutaneous ulceration from sickle cell disease negatively impacts quality of life. Topical sodium nitrite has previously been shown to reduce the size of sickle leg ulcers. This study examined how topical sodium nitrite impacted the quality of life scores in patients with sickle leg ulcers. Read More

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http://dx.doi.org/10.1097/MD.0000000000012614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257663PMC
November 2018
6 Reads

The Impact of Individual and Parental American Indian Boarding School Attendance on Chronic Physical Health of Northern Plains Tribes.

Fam Community Health 2019 Jan/Mar;42(1):1-7

University of Colorado Anschutz Medical Campus, Centers for American Indian and Alaska Native Health, Colorado School of Public Health, Aurora (Drs Running Bear, Croy, Kaufman, and Manson); and Department of Anthropology, Dartmouth College, Hanover, New Hampshire (Dr Thayer).

This study investigated the relationship of American Indian boarding school attendance and chronic physical health. We hypothesized boarding school attendance would be associated with an increased number of chronic physical health problems. We also examined the relationship between boarding school attendance and the 15 chronic health problems that formed the count of the chronic health conditions. Read More

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http://Insights.ovid.com/crossref?an=00003727-201901000-0000
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http://dx.doi.org/10.1097/FCH.0000000000000205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241300PMC
January 2019
18 Reads

Posterior reversible encephalopathy syndrome with extensive cytotoxic edema after blood transfusion: a case report and literature review.

BMC Neurol 2018 Nov 12;18(1):190. Epub 2018 Nov 12.

Division of Neurology, Department of Internal Medicine IV, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, 569-8686, Japan.

Background: Posterior reversible encephalopathy syndrome (PRES) is described as a clinical-radiological disease entity with good prognosis. In brain MRI, PRES generally presents with vasogenic edema. Although PRES is induced by various causes, a small number of PRES cases have occurred after red cell blood transfusion. Read More

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http://dx.doi.org/10.1186/s12883-018-1194-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231260PMC
November 2018

Relapsed/refractory acquired thrombotic thrombocytopenic purpura in a patient with Sjögren syndrome: Case report and review of the literature.

Medicine (Baltimore) 2018 Oct;97(43):e12989

Department of Immunology and Rheumatology.

Rationale: Thrombotic thrombocytopenic purpura (TTP) is a rare, fatal disorder which could be caused by autoimmune diseases. However, TTP secondary to Sjögren syndrome (SS) is extremely rare.

Patient Concerns: A 47-year- old woman with an 8-year history of SS was admitted due to skin ecchymosis and bleeding gums. Read More

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http://dx.doi.org/10.1097/MD.0000000000012989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221612PMC
October 2018
10 Reads

G6PD deficiency, primaquine treatment, and risk of haemolysis in malaria-infected patients.

Malar J 2018 Nov 8;17(1):415. Epub 2018 Nov 8.

Microbiology Research Institute, National Autonomous University of Honduras, Tegucigalpa, Honduras.

Background: The incidence of malaria in the Americas has decreased markedly in recent years. Honduras and the other countries of Mesoamerica and the island of Hispaniola have set the goal of eliminating native malaria by the year 2020. To achieve this goal, Honduras has recently approved national regulations to expand the possibilities of a shortened double dose primaquine (PQ) treatment for vivax malaria. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-018-2564-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225638PMC
November 2018
15 Reads

Molecular analysis of hemoglobinopathies in a large ethnic Hakka population in southern China.

Medicine (Baltimore) 2018 Nov;97(45):e13034

Clinical Core Laboratory.

Thalassemia is an inherited autosomal recessive disorder with microcytic hypochromic anemia resulting from reduced or absent synthesis of 1 or more of the globin chains of hemoglobin. This study provided the insight into prevalence and molecular characterization of thalassemia in Hakka population. 14,524 unrelated subjects were included in our study from January 2015 to November 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000013034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250515PMC
November 2018
1 Read

Daratumumab for Delayed Red-Cell Engraftment after Allogeneic Transplantation.

N Engl J Med 2018 11;379(19):1846-1850

From the Dana-Farber Cancer Institute at St. Elizabeth's Medical Center (C.I.C.), Blood Bank, Department of Pathology (R.M.K.), and the Division of Hematology (J.M.C.), Brigham and Women's Hospital, and the Department of Medical Oncology, Dana-Farber Cancer Institute (E.P.A.) - all in Boston; and the Department of Hematology and Oncology, University Medical Center, Göttingen, Germany (C.I.C.).

Daratumumab, a human IgG1κ monoclonal antibody targeting CD38, is used to treat multiple myeloma. We describe successful treatment with daratumumab in a case of treatment-refractory pure red-cell aplasia after ABO-mismatched allogeneic stem-cell transplantation. The patient was a 72-year-old man with the myelodysplastic syndrome who received a transplant from an HLA-matched, unrelated donor with a major ABO incompatibility (blood group A in the donor and blood group O in the recipient). Read More

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http://dx.doi.org/10.1056/NEJMoa1807438DOI Listing
November 2018
1 Read

Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma.

N Engl J Med 2018 11;379(19):1811-1822

From the National and Kapodistrian University of Athens, Athens (M.A.D.); Karol Marcinkowski University of Medical Sciences, Poznań (D.D.), and Silesian Medical University, Katowice (S.G.) - both in Poland; University Hospital, Nantes (P.M.), and Centre Hospitalier Universitaire de Poitiers-La Milétrie, Poitiers (X.L.) - both in France; National Hospital Organization Disaster Medical Center (N.T.) and the Japanese Red Cross Medical Center (K.S.), Tokyo, and Ibaraki Prefectural Central Hospital, Kasama (M.H.) - all in Japan; Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal (R.L.); Heidelberg University Hospital, Heidelberg, Germany (M.S.R.); Dana-Farber Cancer Institute, Boston (P.G.R.); Bristol-Myers Squibb, Princeton, NJ (M.P.M., Y.-M.J., S.G.S., M.R., B.R.); and Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra (IDISNA), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Pamplona, Spain (J.S.-M.).

Background: The immunostimulatory monoclonal antibody elotuzumab plus lenalidomide and dexamethasone has been shown to be effective in patients with relapsed or refractory multiple myeloma. The immunomodulatory agent pomalidomide plus dexamethasone has been shown to be effective in patients with multiple myeloma that is refractory to lenalidomide and a proteasome inhibitor.

Methods: Patients with multiple myeloma that was refractory or relapsed and refractory to lenalidomide and a proteasome inhibitor were randomly assigned to receive elotuzumab plus pomalidomide and dexamethasone (elotuzumab group) or pomalidomide and dexamethasone alone (control group). Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1805762
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http://dx.doi.org/10.1056/NEJMoa1805762DOI Listing
November 2018
9 Reads

Optimal threshold for the diagnosis of anemia severity on unenhanced thoracic CT: A preliminary study.

Eur J Radiol 2018 Nov 9;108:236-241. Epub 2018 Oct 9.

Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University, No. 168, Gushan Road, Nanjing, Jiangsu Province, 211100, China. Electronic address:

Objective: To investigate and evaluate the value as accuracy of diagnosis different degrees of anemia through the unenhanced thoracic computed tomography (CT) scan.

Materials And Methods: The CT attenuation of right ventricle (RV) cavity, left ventricular (LV) cavity, interventricular septum and difference between the interventricular septum and left ventricle cavity (IVS-LV) were retrospectively analyzed and measured in 317 patients with different degrees of anemia and the normal patients. The hemoglobin (Hb) level was estimated within 24 h. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.10.007DOI Listing
November 2018
2 Reads

Mycobacterium tuberculosis complex bacteremia among HIV and non-HIV patients in a Mexican tertiary care center.

Braz J Infect Dis 2018 Sep - Oct;22(5):387-391. Epub 2018 Oct 30.

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Medicina, Ciudad de México, Mexico. Electronic address:

Objectives: To determine the factors associated with Mycobacterium tuberculosis complex-positive blood culture.

Methods: Case-control study. Sociodemographic, clinical and laboratory data were collected from 2000 to 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14138670183050
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http://dx.doi.org/10.1016/j.bjid.2018.10.274DOI Listing
January 2019
7 Reads

Indwelling ports for prophylactic RBC exchanges in sickle cell patients: Comparison of bard and vortex ports.

J Clin Apher 2018 Dec 2;33(6):666-670. Epub 2018 Nov 2.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Introduction: Red blood cell exchange (RCE) procedures are commonly used for stroke prevention in sickle cell disease (SCD) patients. We compared two different dual lumen ports used for RCE because differences between the port and catheter design may lead to functional variance.

Methods: We reviewed the RCE parameters of SCD patients following implantable port placement encountered at a single institution. Read More

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http://dx.doi.org/10.1002/jca.21663DOI Listing
December 2018

Macrocytic anemia is associated with the severity of liver impairment in patients with hepatitis B virus-related decompensated cirrhosis: a retrospective cross-sectional study.

BMC Gastroenterol 2018 Nov 1;18(1):161. Epub 2018 Nov 1.

Department of Psychiatry, the First Affiliated Hospital, Xi'an Jiaotong University, No.277 Yanta West Road, Yanta District, Xi'an, 710061, People's Republic of China.

Background: Macrocytic anemia is common in liver disease. However, its role in hepatitis B virus (HBV)-related decompensated cirrhosis remains unknown. The aim of the present study was to determine the association between macrocytic anemia and the severity of liver impairment in patients with HBV-related decompensated cirrhosis according to the Model for End Stage Liver Disease (MELD) score. Read More

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http://dx.doi.org/10.1186/s12876-018-0893-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211489PMC
November 2018
1 Read

Invasive nontyphoidal Salmonella disease in southern India: a 5-year experience from a tertiary care hospital

Turk J Med Sci 2018 Oct 31;48(5):1030-1035. Epub 2018 Oct 31.

Background/aim: The current study was carried out to describe the clinical presentation, antimicrobial susceptibility pattern, and outcome of invasive nontyphoidal Salmonella disease (iNTS) in a tertiary care center. Materials and methods: A 5-year hospital-based retrospective study was carried out on blood culture-confirmed cases of iNTS. Medical records of patients were reviewed to obtain information on demography, clinical manifestations, comorbidities, complications, immune status, treatment, and clinical outcome. Read More

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http://dx.doi.org/10.3906/sag-1804-90DOI Listing
October 2018
4 Reads

Alterations of anticoagulant proteins and soluble endothelial protein C receptor in thalassemia patients of Chinese origin.

Thromb Res 2018 12 18;172:61-66. Epub 2018 Oct 18.

Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province 530021, China. Electronic address:

Background: Thalassemia is characterized by a hypercoagulable state in which the protein C (PC) pathway controls thrombosis. We investigated changes in PC, protein S (PS), antithrombin III (AT III) and soluble endothelial protein C receptor (sEPCR) in thalassemia.

Methods: A group of 129 patients with β-thalassemia major (β-TM), β-thalassemia intermedia (β-TI), α-thalassemia intermedia (α-TI) and combined α-/β-thalassemia (α + β-thal) were compared with 32 gender- and age-matched controls. Read More

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http://dx.doi.org/10.1016/j.thromres.2018.10.016DOI Listing
December 2018
1 Read

Prevalence of monoclonal gammopathy of uncertain significance in chronic myeloid leukemia: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e13103

Rationale: The abnormal cell types in chronic myeloid leukemia (CML) and monoclonal gammopathy of uncertain (MGUS) are quite different, being myeloid and plasma cells, respectively. The coexistence of CML and MGUS is an uncommon event, which is seldom reported in literature.

Patient Concerns: A 52-year-old female was diagnosed with CML in April 2001. Read More

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http://dx.doi.org/10.1097/MD.0000000000013103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221681PMC
November 2018
2 Reads

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma.

N Engl J Med 2018 11;379(18):1711-1721

From Stanford University, Stanford (R.A., T.T., R.M., I.L.W.), City of Hope, Duarte (L.P.), and Forty Seven, Menlo Park (J.L., J.Y.C., J.-P.V., B.A., J.H., R.M., I.L.W., C.H.T., M.P.C.) - all in California; Sarah Cannon Research Institute-Tennessee Oncology, Nashville (I.F.); University of Alabama at Birmingham, Birmingham (A.F.); Washington University in St. Louis, St. Louis (N.L.B.); Levine Cancer Institute-Atrium Health, Charlotte, NC (N.G.); University of Chicago, Chicago (J.K., S.M.S.); National Cancer Institute, Rockville, MD (M.R.); Dana-Farber Cancer Institute, Boston (A.L.); and University of Oxford, Oxford, United Kingdom (G.P.C.).

Background: The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune checkpoint inhibitor blocking CD47 that induces tumor-cell phagocytosis. 5F9 synergizes with rituximab to eliminate B-cell non-Hodgkin's lymphoma cells by enhancing macrophage-mediated antibody-dependent cellular phagocytosis. This combination was evaluated clinically. Read More

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http://dx.doi.org/10.1056/NEJMoa1807315DOI Listing
November 2018
51 Reads
55.873 Impact Factor

[Sebaceous hamartoma on the face: about a case].

Pan Afr Med J 2018 14;30:132. Epub 2018 Jun 14.

Service de Dermatologie-Vénérologie, Hôpital d'Instruction Mohammed V, Rabat, Maroc.

Sebaceous naevus (sebaceous hamartoma) is a congenital lesion mainly localized to the scalp, whose clinical and histologic diagnosis is generally easy. In the vast majority of cases, it is diagnosed at birth, but it can sometimes go unnoticed and give the impression to occur later. This lesion may be complicated by benign tumors or more rare malignancies. Read More

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http://www.panafrican-med-journal.com/content/article/30/132
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http://dx.doi.org/10.11604/pamj.2018.30.132.14911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201613PMC
November 2018
9 Reads

Glucose-6-phosphate dehydrogenase (G6PD) deficiency in Ethiopia: absence of common African and Mediterranean allelic variants in a nationwide study.

Malar J 2018 Oct 26;17(1):388. Epub 2018 Oct 26.

US President's Malaria Initiative, Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Building on the declining trend of malaria in Ethiopia, the Federal Ministry of Health aims to eliminate malaria by 2030. As Plasmodium falciparum and Plasmodium vivax are co-endemic in Ethiopia, the use of primaquine is indicated for both transmission interruption and radical cure, respectively. However, the limited knowledge of the local prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency and its associated variants has hindered the use of primaquine. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-018-2538-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204031PMC
October 2018
9 Reads
3.110 Impact Factor

A positive direct Coombs' test in the absence of hemolytic anemia predicts high disease activity and poor renal response in systemic lupus erythematosus.

Lupus 2018 Dec 25;27(14):2274-2278. Epub 2018 Oct 25.

Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

We determined the clinical utility of the direct Coombs' test in the absence of hemolytic anemia as an indicator of disease activity and therapeutic response in systemic lupus erythematosus (SLE). SLE patients without hemolytic anemia who visited our hospital from January 2016 to November 2016 were retrospectively evaluated with a direct Coombs' test. Clinical features, including SLE disease activity index (SLEDAI), treatment and laboratory findings were analyzed. Read More

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http://dx.doi.org/10.1177/0961203318809182DOI Listing
December 2018
1 Read

Impact of splicing factor mutations on clinical features in patients with myelodysplastic syndromes.

Int J Hematol 2018 Dec 23;108(6):598-606. Epub 2018 Oct 23.

Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan.

Splicing factor gene mutations are found in 60-70% of patients with myelodysplastic syndromes (MDS). We investigated the effects of splicing factor gene mutations on the diagnosis, patient characteristics, and prognosis of MDS. A total of 106 patients with MDS were included. Read More

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http://dx.doi.org/10.1007/s12185-018-2551-yDOI Listing
December 2018
4 Reads

Changes in Hemoglobin Concentrations Post-immunoglobulin Therapy in Patients with Kawasaki Disease: A Population-Based Study Using a Claims Database in Japan.

Paediatr Drugs 2018 Dec;20(6):585-591

Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.

Background: We sought to quantify the degree of anemia after high-dose intravenous immunoglobulin (IVIG) therapy in patients with Kawasaki disease (KD) by assessing hemoglobin (Hb) dynamics and determining the risk of transfusion.

Methods: We analyzed data from a database containing inpatient data collected from 230 hospitals in Japan. In addition to administrative records, this database included laboratory results for some patients. Read More

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http://dx.doi.org/10.1007/s40272-018-0316-yDOI Listing
December 2018
2 Reads

Plasma hemoglobin concentration among pregnant and non-pregnant women in Mwanza: are we using correct reference values to diagnose anemia in pregnancy?

Pan Afr Med J 2018 31;30:93. Epub 2018 May 31.

Department of Obstetrics and Gynaecology, Bugando Medical Center, Mwanza, Tanzania.

Introduction: The definition of anemia has attracted considerable interest because several studies have demonstrated that hematologic profile vary with ethnicity in addition to age, sex and altitude. This has led scholars to recommend the use of population specific hematologic reference values in diagnosing blood disorders. However, there is limited information about Tanzanians population specific hemoglobin (Hb) levels which can be used to set cut-off points to define anemia. Read More

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http://www.panafrican-med-journal.com/content/article/30/93/
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http://dx.doi.org/10.11604/pamj.2018.30.93.11954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191253PMC
October 2018
7 Reads

Malnutrition among HIV infected children under 5 years of age at the Laquintinie hospital Douala, Cameroon.

Pan Afr Med J 2018 31;30:91. Epub 2018 May 31.

Department of Pediatrics, Faculty of Biomedical Sciences, University of Yaoundé I, Cameroon.

Introduction: The aim of this study was to assess the prevalence of malnutrition among HIV infected children under five years of age followed up at the Laquintinie Hospital Douala (LHD).

Methods: Medical records of children aged 13 days-59 months enrolled at initiation of antiretroviral treatment in the Day Care Unit/LHD, were reviewed for a period of 14 years (from 2002 to 2015). We used standard Z-scores, with cut-off point of <-2 SD to define low height-for-age (HAZ), low weight-for-height (WHZ) and low weight-for-age (WAZ). Read More

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http://www.panafrican-med-journal.com/content/article/30/91/
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http://dx.doi.org/10.11604/pamj.2018.30.91.15832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191246PMC
October 2018
9 Reads

D1359Y mutation in a patient with gastric polyposis and cancer susceptibility: A case report and review of literature.

World J Gastroenterol 2018 Oct;24(38):4412-4418

Division of Hematology and Medical Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 10491, Taiwan.

Gastric polyposis is a rare disease. Not all polyps progress to cancer. Monoallelic mutation in Fanconi anemia (FA) genes, unlike biallelic gene mutations that causes typical FA phenotype, can increase risks of cancers in a sporadic manner. Read More

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http://dx.doi.org/10.3748/wjg.v24.i38.4412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189845PMC
October 2018
2 Reads

Content validity of the PROMIS® pediatric family relationships measure for children with chronic illness.

Health Qual Life Outcomes 2018 Oct 19;16(1):203. Epub 2018 Oct 19.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, 53792, USA.

Background: Families play a critical role in supporting the health and well-being of children with chronic illnesses, who face a lifetime of responsibility for self-management of their condition. Our goal was to investigate whether the novel Patient-Reported Outcomes Measurement Information System® (PROMIS®) Pediatric Family Relationships measure, developed primarily within the general pediatric population, reflects the experiences of family relationships for chronically ill children and their parents.

Methods: We conducted semi-structured qualitative interviews with children (aged 8-17) with common chronic conditions: asthma (n = 6), type 1 diabetes (n = 5), or sickle cell disease (n = 5), and separately with one of their parents (n = 16). Read More

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https://hqlo.biomedcentral.com/articles/10.1186/s12955-018-1
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http://dx.doi.org/10.1186/s12955-018-1030-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194608PMC
October 2018
8 Reads