559 results match your criteria Anemia Myelophthisic


Myelophthisic Anemia in a Patient with Lobular Breast Carcinoma Metastasized to the Bone Marrow.

Cureus 2018 Nov 4;10(11):e3541. Epub 2018 Nov 4.

Hematology / Oncology, The Brooklyn Hospital Center, Brooklyn, USA.

Breast tumors have a predilection for metastasizing to the bone leading to cells being displaced by the cancer cells subsequently producing immature leukocytes and erythrocytes in the peripheral blood. We present a case of a 57-year-old female who was found to have myelophthisic anemia secondary to stage four lobular breast carcinoma metastasized to the bone marrow after being misdiagnosed as having thrombotic thrombocytopenia purpura. Diagnosis of myelophthisic anemia requires a thorough workup and treatment is based upon secondary management of the malignancy. Read More

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http://dx.doi.org/10.7759/cureus.3541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324862PMC
November 2018
12 Reads

Myelophthisic marrow involved by breast cancer and acute myeloid leukemia.

Blood 2018 03;131(9):1036

Stanford University School of Medicine.

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http://dx.doi.org/10.1182/blood-2017-10-809921DOI Listing
March 2018
10 Reads

An elderly man with hemolysis and myelophthisic anemia.

Eur J Intern Med 2018 02 8;48:e7-e8. Epub 2017 Jul 8.

Department of Internal Medicine, The University of Texas Health Sciences Centre at Houston, Houston, TX, USA; Department of Critical Care, Pulmonary and Sleep Medicine, The University of Texas Health Sciences Centre at Houston, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2017.07.004DOI Listing
February 2018
17 Reads

Response after treatment with pembrolizumab in a patient with myelophthisis due to melanoma: the role of checkpoint inhibition in the bone.

J Immunother Cancer 2017 18;5:34. Epub 2017 Apr 18.

Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065 USA.

Background: Myelophthisis due to melanoma is a rare phenomenon. Treatment strategies for patients with this serious complication of malignancy have not been well documented, and none have previously reported efficacy of immune checkpoint inhibition. Since bone metastases are not measurable lesions per standard response criteria, the efficacy of immune checkpoint inhibition in the bones is also not well described. Read More

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http://dx.doi.org/10.1186/s40425-017-0236-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394614PMC
June 2018
11 Reads

[Myelophthisis and kasabach merrit syndrome as initial manifestation of splenic angiosarcoma].

Rev Fac Cien Med Univ Nac Cordoba 2016 ;73(4):297-301

Primary splenic angiosarcoma is an extremely agressive and rare neoplasm. Manifestations as bone marrow invasion and coagulation disorders have been reported isolatedly. A 26 years-old woman presented with abdominal pain; several anemia and thrombocytopenia associated to leukoerythroblastic reaction were found in the laboratory. Read More

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May 2017
40 Reads

Leucoerythroblastic anaemia, abnormal bone scan and prostate cancer with a primary haematological diagnosis.

Br J Haematol 2015 Jan 13;168(2):161. Epub 2014 Oct 13.

Department of Haematology, Ninewells Hospital, Dundee, UK.

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http://dx.doi.org/10.1111/bjh.13169DOI Listing
January 2015
9 Reads

An aggressive presentation of colorectal cancer with an atypical lymphoproliferative pattern of metastatic disease: a case report and review of the literature.

Clin Colorectal Cancer 2014 Sep 23;13(3):e5-e11. Epub 2014 Jun 23.

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA.

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https://linkinghub.elsevier.com/retrieve/pii/S15330028140005
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http://dx.doi.org/10.1016/j.clcc.2014.05.002DOI Listing
September 2014
18 Reads

A man with anemia and a change in personality.

Blood 2014 Mar;123(12):1784

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March 2014
9 Reads

Signet ring cell carcinoma's myelophthisis.

BMJ Case Rep 2014 Mar 12;2014. Epub 2014 Mar 12.

Department of Medicina I, Hospital Egas Moniz, Lisboa, Portugal.

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http://dx.doi.org/10.1136/bcr-2014-203662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962914PMC
March 2014
4 Reads

Severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis in two Syrian refugee infants: a challenge to differentiate from acute leukaemia.

BMJ Case Rep 2014 Mar 5;2014. Epub 2014 Mar 5.

Department of Pediatric Hematology and Oncology, Gaziantep Childrens' Hospital, Gaziantep, Turkey.

Megaloblastic anaemia due to vitamin B12 deficiency is rare in childhood. However, as most cases are due to maternal insufficiency, it is mainly seen in breastfed infants especially when the mother's socioeconomic status is low and the nutrition is not adequate. We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis. Read More

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http://casereports.bmj.com/content/2014/bcr-2014-203742.full
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http://casereports.bmj.com/cgi/doi/10.1136/bcr-2014-203742
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http://dx.doi.org/10.1136/bcr-2014-203742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948160PMC
March 2014
12 Reads

Leucoerythroblastosis and thrombocytopenia as clues to metastatic malignancy.

Authors:
E J Mahdi A J Mahdi

BMJ Case Rep 2014 Jan 31;2014. Epub 2014 Jan 31.

Cardiff University School of Medicine, Cardiff, UK.

The association of metastatic breast cancer presenting as thrombocytopenia and anaemia is demonstrated in the following case of a 79-year-old woman. Her main symptoms were abdominal pain, altered bowel habit and weight loss. Without a clear causative pathology, she underwent a CT scan which demonstrated multiple sclerotic bone lesions. Read More

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http://dx.doi.org/10.1136/bcr-2013-202612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912367PMC
January 2014
1 Read

Metastatic malignant melanoma detected on bone marrow aspiration.

Br J Haematol 2013 Aug 24;162(4):432. Epub 2013 Jun 24.

Department of Haematology, Hospital Ramón y Cajal, Madrid, Spain.

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http://dx.doi.org/10.1111/bjh.12437DOI Listing
August 2013
15 Reads

Case of metastatic basal cell carcinoma to bone marrow, resulting in myelophthisic anemia.

Am J Dermatopathol 2013 Apr;35(2):e34-6

Division of Dermatology and Cutaneous Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Background: While basal cell carcinoma (BCC) remains the most common skin cancer, the incidence of metastasis is rare. Most cases of metastatic BCC have been to regional lymph nodes. Metastasis to bone marrow with myelophthisic anemia is especially rare. Read More

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http://dx.doi.org/10.1097/DAD.0b013e3182761362DOI Listing
April 2013
17 Reads

Clinical, histopathologic, and genetic features of pediatric primary myelofibrosis--an entity different from adults.

Am J Hematol 2012 May 3;87(5):461-4. Epub 2012 Mar 3.

Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, 6701 Fannin Street, Houston, TX 77030-2399, USA.

Primary myelofibrosis is a chronic myeloproliferative neoplasm characterized by cytopenias, leukoerythroblastosis, extramedullary hematopoiesis, hepatosplenomegaly and bone marrow fibrosis. Primary myelofibrosis is a rare disorder in adults; children are even less commonly affected by this entity, with the largest pediatric case series reporting on three patients. Most literature suggests spontaneous resolution of myelofibrosis without long term complications in the majority of affected children. Read More

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http://doi.wiley.com/10.1002/ajh.23140
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http://dx.doi.org/10.1002/ajh.23140DOI Listing
May 2012
15 Reads

The cause of sudden anemia revealed by the blood film.

Am J Hematol 2012 May 26;87(5):520. Epub 2011 Sep 26.

Department of Paediatric Haematology, St Mary's Hospital, Praed Street, London, UK.

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http://dx.doi.org/10.1002/ajh.22158DOI Listing
May 2012
35 Reads

Myelophthisis in breast cancer.

Am J Hematol 2011 Jan;86(1):70-1

Ematologia/Coagulazione, Laboratorio di Chimica-Clinica, Ematologia e Microbiologia, Azienda Ospedaliera S. Antonio Abate, Varese, Gallarate, Italy.

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http://doi.wiley.com/10.1002/ajh.21927
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http://dx.doi.org/10.1002/ajh.21927DOI Listing
January 2011
32 Reads

Microangiopathic hemolytic anemia and leukoerythroblastic blood film heralding bone marrow metastatic gastroesophageal adenocarcinoma.

Pathol Res Pract 2011 Feb 5;207(2):121-3. Epub 2010 Aug 5.

Haematopathology Residency Program, University of Toronto, Toronto, Canada.

Despite modern technological advancements in laboratory hematology, the blood film remains an important diagnostic aid. Herein, we report the case of a patient with a history of gastric cancer, who presented seven years following apparently successful surgery and adjuvant chemo-radio-therapy, with blood film findings of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and leukoerythroblastosis (LEB). Although mimicking features of thrombotic thrombocytopenic purpura (TTP), subsequent bone marrow examination instead revealed an association with occult recurrence of necrotic, metastatic gastric adenocarcinoma. Read More

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http://dx.doi.org/10.1016/j.prp.2010.07.003DOI Listing
February 2011
8 Reads

Ghosal hematodiaphyseal dysplasia: a rare cause of a myelophthisic anemia.

Pediatr Blood Cancer 2010 Dec;55(6):1187-90

The Johns Hopkins University School of Medicine, Division of Hematology, Baltimore, Maryland, USA.

Ghosal hematodiaphyseal dysplasia syndrome (GHDD) is a rare clinical syndrome characterized by increased bone density and a severe, myelophthisic anemia. Few cases have been reported worldwide and there are no detailed descriptions of the associated hematologic abnormalities and long-term clinical outcomes after treatment. Here, we report two siblings with GHDD who were successfully treated with chronic, low dose, corticosteroid therapy. Read More

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http://dx.doi.org/10.1002/pbc.22662DOI Listing
December 2010
13 Reads

Osteopetrosis-associated osteomyelitis of the jaws: a report of 4 cases.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 Sep;108(3):e56-65

Department of Oral Medicine and Radiology, Meenakshi Ammal Dental College and Hospital, Chennai, India.

Osteopetrosis represents a heterogeneous group of rare, hereditary bone disorders with variable clinical features and an increase in bone density. The common clinical findings that usually lead to the detection of the disease are fractures and osteomyelitis of the mandible. We report 4 cases of osteopetrosis, complicated by osteomyelitis of the jaws. Read More

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http://dx.doi.org/10.1016/j.tripleo.2009.05.010DOI Listing
September 2009
6 Reads
5 Citations

Osteopetrosis: a rare cause of anemia--review of literature.

Indian J Pathol Microbiol 2009 Jul-Sep;52(3):363-7

Department of Hematology, VM Medical College and Safdarjung Hospital, New Delhi, India.

Normocytic anaemia is caused either by hypoproliferation of haemopoietic tissue or increased destruction of red cell. Osteopetrosis is a rare cause of anaemia. The leading clinical features are pallor, growth failure, hepatosplenomegaly. Read More

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http://dx.doi.org/10.4103/0377-4929.54995DOI Listing
October 2009
5 Reads

Transient leukoerythroblastosis in a very low birth weight infant with parvovirus B19 infection.

Int J Infect Dis 2009 Nov 23;13(6):e473-5. Epub 2009 Mar 23.

Department of Pediatrics, Trakya University Faculty of Medicine, 22030 Edirne, Turkey.

Background: Leukoerythroblastosis is characterized by the presence of leukocytosis and erythroid and myeloid blast cells in the peripheral blood. The most common etiological factors of leukoerythroblastosis occurring during early childhood are viral infections, juvenile myelomonocytic leukemia, and osteopetrosis. To our knowledge, an association with parvovirus B19 infection has only been reported in a preterm infant. Read More

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http://dx.doi.org/10.1016/j.ijid.2009.01.002DOI Listing
November 2009
6 Reads

Bone marrow necrosis and myelophthisis: manifestations of T-cell lymphoma in a horse.

Vet Clin Pathol 2008 Dec;37(4):403-8

Department of Veterinary Clinical Sciences, Oklahoma State University, Stillwater, OK, USA.

A 14-year-old spayed American Paint mare was evaluated for mild colic, anorexia, pyrexia, and pancytopenia. Physical examination revealed mild tachycardia, tachypnea, and pale mucous membranes. Serial laboratory analyses revealed progressive pancytopenia, hyperfibrinogenemia, and hyperglobulinemia. Read More

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http://dx.doi.org/10.1111/j.1939-165X.2008.00069.xDOI Listing
December 2008
27 Reads

Severe vitamin B12 deficiency resulting in pancytopenia, splenomegaly and leukoerythroblastosis.

Eur J Haematol 2008 May 23;80(5):448-51. Epub 2008 Jan 23.

Department of Internal Medicine, Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA.

Deficiency of vitamin B12 is a well known cause of megaloblastic anemia and pancytopenia. Splenomegaly and leukoerythroblastosis are much less well known manifestations of B12 deficiency. We report a B12 deficient female with severe pancytopenia including normocytic anemia who also had enlarged spleen and circulating nucleated red blood cells as well as circulating immature myeloid cells. Read More

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http://doi.wiley.com/10.1111/j.1600-0609.2008.01043.x
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http://dx.doi.org/10.1111/j.1600-0609.2008.01043.xDOI Listing
May 2008
9 Reads

Effects of weiganli on the hemopoietic function of the myelosuppressed anemic mice.

J Tradit Chin Med 2007 Jun;27(2):143-7

Department of Histology, Embryology and Neurobiology, School of Basic Medical Sciences of Sichuan University, Chengdu 610041, China.

Objective: To study the effect of weiganli ([Chinese characters: see text]) on bone marrow hemopoiesis.

Methods: The effects of weiganli on the peripheral blood picture and the number of bone marrow nucleated cells (BMCs) were observed in myelosuppressed anemic model mice, and the effects of weiganli on the growth of colony forming unit-granulocyte macrophage (CFU-GM), colony forming unit-erythroid (CFU-E), burst forming unit-erythroid (BFU-E), colony forming unit-megkaryocyte (CFU-Meg) were investigated by in vitro cell culture technique. The hemopoietic stem cells (HSCs, c-kit+) in bone marrow were double stained with fluorescent antibody PE-C-Kit and FITC-CD45, and the HSCs (c-kit+) were counted by flow cytometer with CD45/SSC (side scatter) gating. Read More

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June 2007
7 Reads

Leukoerythroblastic anemia due to oxalosis with extensive bone marrow involvement.

Am J Hematol 2008 Jun;83(6):515-6

Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia 08916, Spain.

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http://dx.doi.org/10.1002/ajh.20935DOI Listing
June 2008
7 Reads

Lenalidomide therapy in myelofibrosis with myeloid metaplasia.

Blood 2006 Aug 11;108(4):1158-64. Epub 2006 Apr 11.

Division of Hematology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

We present results of 2 similarly designed but separate phase 2 studies involving single-agent lenalidomide (CC-5013, Revlimid) in a total of 68 patients with symptomatic myelofibrosis with myeloid metaplasia (MMM). Protocol treatment consisted of oral lenalidomide at 10 mg/d (5 mg/d if baseline platelet count < 100 x 10(9)/L) for 3 to 4 months with a plan to continue treatment for either 3 or 24 additional months, in case of response. Overall response rates were 22% for anemia, 33% for splenomegaly, and 50% for thrombocytopenia. Read More

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http://www.bloodjournal.org/content/108/4/1158.full.pdf
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http://www.bloodjournal.org/content/early/2006/04/11/blood-2
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-02-00
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http://dx.doi.org/10.1182/blood-2006-02-004572DOI Listing
August 2006
41 Reads

Premature labor and leukoerythroblastosis in a newborn with parvovirus B19 infection.

Haematologica 2005 Nov;90 Suppl:ECR38

Celal Bayar University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Hematology.

Leukoerythroblastosis is a rarely observed disease characterized by the presence of leukocytosis, erythroid and myeloid blast cells in peripheral blood. To our knowledge, it had not been diagnosed in a premature newborn before the case we report have.A female baby weighing 1164 grams, who was born prematurely at the 29th week of gestation by Cesarean section was referred to our newborn intensive care unit due to prematurity and respiratory distress with no prenatal pathological findings. Read More

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November 2005
18 Reads

High number of circulating CD34+ cells in patients with myelophthisis.

Haematologica 2005 Jul;90(7):976-7

Six patients with bone marrow micrometastases from solid cancers presented with increased numbers of circulating CD34+ cells; the CD34+ cell counts were very high in some cases. By contrast, no patient with metastatic cancer without bone marrow involvement showed raised numbers of circulating hemopoietic progenitors. Read More

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July 2005
16 Reads

Clinical spectrum of myelophthisis in cancer patients.

Am J Hematol 2004 May;76(1):92-3

Hematology and Medical Oncology, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA.

Myelophthisis is a form of bone marrow failure due to replacement of hematopoietic tissue by abnormal tissue, most commonly metastatic carcinomas. This results in extramedullary hematopoiesis, typically in the spleen leading to premature release of hematopoietic cells into the circulation. Peripheral blood findings may include nucleated red blood cells, tear drop forms, giant platelets, and immature leukocytes. Read More

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http://dx.doi.org/10.1002/ajh.20046DOI Listing
May 2004
29 Reads

Oxalosis: an unusual cause of leucoerythroblastic anaemia.

Br J Haematol 2003 Jul;122(1)

Department of Haematology, Royal Brompton and Harefield NHS Trust, Harefield Hospital, Harefield, UK.

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July 2003
6 Reads

Angiosarcoma presenting with leucoerythroblastic anaemia bone marrow fibrosis and massive splenomegaly.

Br J Haematol 2000 Sep;110(3):503

Department of Haematology, Histopathology & Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh-160012, India.

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September 2000
9 Reads

Myelophthisis as a solitary manifestation of failure from rectal carcinoma. A Batson phenomenon?

Arch Pathol Lab Med 2000 Aug;124(8):1228-30

Division of Medical Oncology, University of Texas Medical Branch, Galveston 77555-0565, USA.

Rectal carcinoma is uncommonly associated with systemic metastases in the absence of liver metastases, reflecting the predilection for spread via the portal system. Occasionally, isolated lung metastases are seen, which are usually attributed to spread via the portosystemic anastomoses in the distal rectum. However, myelophthisis is an unreported complication of rectal cancer as an isolated form of systemic failure. Read More

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http://dx.doi.org/10.1043/0003-9985(2000)124<1228:MAASMO>2.0.CO;2DOI Listing
August 2000
6 Reads

Leukoerythroblastosis and normoblastemia in the cat.

J Am Anim Hosp Assoc 1999 Nov-Dec;35(6):471-3

North Coast Veterinary Specialist, Madison, Ohio 44057, USA.

Over a six-month period, 6% of 313 cats evaluated hematologically had either leukoerythroblastosis or normoblastemia. Diseases associated with these hematological conditions included haemobartonellosis, hepatic lipidosis, trauma, viral and bacterial infections, myeloproliferative disorders, and hemangiosarcoma. The finding of leukoerythroblastosis or normoblastemia may aid in diagnosing cats presenting with nonspecific signs. Read More

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http://dx.doi.org/10.5326/15473317-35-6-471DOI Listing
December 1999
8 Reads

Multiple diffuse fibrosarcoma of bone associated with extramedullary hematopoiesis.

Intern Med 1998 May;37(5):480-3

First Department of Internal Medicine, School of Medicine, Ehime University.

We report a case of multiple diffuse fibrosarcoma of bone. The patient, a 38-year-old man, was referred to our hospital with knee pain, anemia and thrombocytopenia. No solid mass was seen on radiographic examination of the kneejoint, but magnetic resonance imaging showed hypointensity of the distal femur. Read More

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May 1998
5 Reads

[Osteomyelitis of the facial skull in Albers-Schönberg osteopetrosis].

Mund Kiefer Gesichtschir 1997 Mar;1(2):121-4

Klinik und Poliklinik für Zahn-, Mund- und Kieferheilkunde, Universität Köln.

Albers-Schönberg osteopetrosis, a rare heritable bone disease with autosomal dominant or recessive transmission, is generally characterised by diffuse sclerosis of the whole skeleton accompanied by pathological bone fragility and delayed physical development, profound intractable myelophthisic anaemia, neurological deficits, and osteomyelitis, especially of the jaws and the skull. The precise aetiology of the osteopetrosis is not clear. Therefore therapy is restricted to alleviation of symptoms. Read More

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http://dx.doi.org/10.1007/BF03043527DOI Listing
March 1997
5 Reads

Transient erythroblastopenia of childhood (TEC) presenting as leukoerythroblastic anemia.

J Pediatr Hematol Oncol 1997 Mar-Apr;19(2):165-7

Division of Pediatric Hematology/Oncology, University of Texas Medical Branch, Galveston 77555-0361, USA.

Purpose: The diagnosis of transient erythroblastopenia of childhood (TEC) is usually straightforward, with temporary cessation of red blood cell production resulting in normocytic normochromic anemia, reticulocytopenia, and bone marrow erythroblastopenia. We describe here a case of TEC presenting with features of leukoerythroblastic anemia. To our knowledge, this is the first such report for TEC. Read More

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June 1997
7 Reads

Bone marrow involvement and obstructive jaundice in Farber lipogranulomatosis: clinical and autopsy report of a new case.

J Inherit Metab Dis 1996 ;19(5):655-60

Division of Clinical Genetics, University of Toronto, Ontario, Canada.

We report a case of Farber lipogranulomatosis in a girl with hepatosplenomegaly, macular cherry-red spot, and subcutaneous nodules who developed liver dysfunction with jaundice and ascites, and myelophthisic anaemia because of infiltration of bone marrow with storage cells. Acid ceramidase assay confirmed the diagnosis. We conclude that the bone marrow dysfunction and cherry-red spot are features of type IV Farber lipogranulomatosis that have not been previously recognized, and should be added to the clinical phenotypic description. Read More

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March 1997
5 Reads

Microangiopathic hemolytic anemia as an initial presentation of metastatic cancer of unknown primary origin.

South Med J 1995 Jun;88(6):683-7

Department of Internal Medicine, Chang Gung Medical College, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.

Microangiopathic hemolytic anemia (MAHA) is a well-documented but rare complication of disseminated cancer; it usually occurs in the late or terminal stage of cancer. We describe a case of metastatic carcinoma of unknown origin in which MAHA was the initial presentation. A 36-year-old woman came to our hospital with lower back pain and progressive exertional dyspnea for 8 weeks. Read More

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June 1995
6 Reads

Case in point. Pseudohyperkalemia secondary to thrombocytosis.

Authors:
J J Olivero

Hosp Pract (Off Ed) 1995 Apr;30(4):26

Department of Internal Medicine, Baylor College of Medicine, Houston, USA.

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April 1995
5 Reads

Correction of anaemia and thrombocytopenia in a case of adult type I osteopetrosis with recombinant human erythropoietin (rHuEPO).

Br J Haematol 1995 Apr;89(4):911-3

First Department of Internal Medicine,University of Athens School of Medicine, Laikon General Hospital, Greece.

A case of adult osteopetrosis Type I was diagnosed in a 22-year-old female. She presented for investigation of anaemia with 'myelophthisic' characteristics and extramedullary haemopoiesis which was resistant to haematinics, nandrolone and low-dose corticosteroids. She became progressively transfusion-dependent with gradually worsening thrombocytopenia. Read More

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April 1995
5 Reads

Metastatic ependymoma manifested by pancytopenia.

South Med J 1994 Dec;87(12):1262-3

Department of Pathology, University of South Florida College of Medicine, Tampa.

We present the case of a 32-year-old white man seen for evaluation of pancytopenia 12 years after thoracolumbar myeloresection of intramedullary ependymoma. Bone marrow examination revealed extensive marrow fibrosis and tumor infiltrate compatible with metastatic ependymoma. Myelophthisic anemia due to metastatic ependymoma, though not previously reported, should be entertained in the differential workup for pancytopenia. Read More

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December 1994
7 Reads

Diagnosis of EDTA-dependent pseudothrombocytopenia in a horse.

J Am Vet Med Assoc 1993 Dec;203(12):1715-6

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210-1089.

Thrombocytopenia in horses may be idiopathic or secondary to chronic infectious or inflammatory diseases (eg, equine infectious anemia, lymphosarcoma), drug administration, bone marrow depression, myelophthisic disease, or disseminated intravascular coagulation. This report describes EDTA-dependent pseudothrombocytopenia in a horse. Platelet counts for blood containing EDTA were consistently less than reference range, but platelet counts of blood containing heparin were within reference range. Read More

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December 1993
9 Reads

Osteopetrosis. Current clinical considerations.

Authors:
F Shapiro

Clin Orthop Relat Res 1993 Sep(294):34-44

Department of Orthopaedic Surgery, Children's Hospital, Boston, MA 02115.

Osteopetrosis is an inherited skeletal condition characterized by increased bone radiodensity. There are three clinical groups: infantile-malignant autosomal recessive, fatal within the first few years of life (in the absence of effective therapy); intermediate autosomal recessive, appears during the first decade of life but does not follow a malignant course; and autosomal dominant, with full-life expectancy but many orthopaedic problems. The infantile variant shows a myelophthisic anemia, granulocytopenia, and thrombocytopenia, and patients eventually die from infection or bleeding or both. Read More

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September 1993
6 Reads

Leukoerythroblastic anemia in metastatic prostate cancer. Clinical and prognostic significance in patients with hormone-refractory disease.

Cancer 1993 Jun;71(11):3594-600

Department of Medicine, University of Arizona College of Medicine, Tucson.

Background: The clinical and prognostic significance of leukoerythroblastic anemia (LKEA) in patients with metastatic prostate cancer and, in general, patients with disseminated solid tumors is poorly understood. Therefore, the authors studied a population of patients with metastatic prostate cancer refractory to hormonal therapy to assess the incidence, clinical features, and prognostic implications of LKEA.

Methods: The medical records of 106 patients with hormone-refractory prostate cancer metastatic to bone seen at the Tucson Veterans Affairs Medical Center between 1985 and 1991 were reviewed retrospectively. Read More

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June 1993
5 Reads

[Differentiating agents in myelodysplastic syndromes. Analysis of personal cases].

Recenti Prog Med 1993 Mar;84(3):168-76

Istituto di Clinica Medica Generale e Terapia Medica, Università, Ancona.

The Myelo-Dysplastic Syndromes are a heterogeneous group of diseases which includes patients with different prognosis. There is no agreement about the management and the therapeutic strategy must be based on many individual parameters, particularly the age of the patients and their performance status. The therapeutic options range from no cytotoxic therapy for low-risk patients up to more aggressive treatment for high-risk patients, with disappointing results except for the very few cases eligible for allogenic bone marrow transplantation. Read More

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March 1993
6 Reads

Comparative susceptibility of African green monkeys (Cercopithecus aethiops) to experimental infection with Leishmania leishmania donovani and Leishmania leishmania infantum.

Lab Anim Sci 1993 Feb;43(1):37-47

Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602.

The leishmaniases are global health problems that affect both humans and animals. The availability of nonhuman primate models is desirable for such important areas as testing candidate vaccines and newly developed chemo- and immunotherapeutic agents. Visceral leishmaniasis was experimentally induced in African green monkeys (Cercopithecus aethiops) by intravenously inoculating 10(7) amastigotes/kg of body weight of either Leishmania leishmania donovani of human origin (group 1) or L. Read More

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February 1993
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