8,548 results match your criteria Anemia Megaloblastic

Thromboembolic complications of recreational nitrous oxide (ab)use: a systematic review.

J Thromb Thrombolysis 2022 Jun 27. Epub 2022 Jun 27.

Department of Radiology, Radiologist, Thoracic Imaging, Jessa Hospital, Hasselt, Belgium.

The recreatinal use of nitrous oxide has become more common in recent years, especially in adolescents and young adults. It has been mainly associated with medical conditions like megaloblastic anemia and (myelo)neuropathy. We report on the thromboembolic complications, a less known side effect, associated with recreational inhalation of nitrous oxide. Read More

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Frequency and utility of bone marrow examination in relapsed/ refractory immune thrombocytopenia.

J Thromb Haemost 2022 Jun 25. Epub 2022 Jun 25.

Division of Hematology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Background: The diagnosis of immune thrombocytopenia (ITP) is one of exclusion. While guidelines recommend against routine bone marrow examination (BME) at time of ITP diagnosis, the role of BME in relapsed/refractory ITP is unclear.

Objectives: To examine the frequency and predictors of BME in relapsed/refractory ITP. Read More

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Spectrum of Pancytopenia in Adults Attending a Clinical Hematology Department: A Four-Year Experience From a Tertiary Care Center of Western India.

Cureus 2022 May 12;14(5):e24933. Epub 2022 May 12.

Emergency Medicine, Dr. Sampurnanand Medical College, Jodhpur, IND.

Background Pancytopenia is a common hematological condition encountered in clinical practice. Because there is a wide variation in causes of pancytopenia even in different populations of the same geographical region, identifying the pattern of underlying etiologies is crucial for proper management. This study was conducted to evaluate the clinico-hematological profile and different etiologies of pancytopenia among adults presenting to a clinical hematology department at a tertiary care hospital of Western India. Read More

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Vitamin B12 and Plant-Predominant Diets.

Nicole D White

Am J Lifestyle Med 2022 May-Jun;16(3):295-297. Epub 2022 May 4.

Creighton University, Omaha, NE, USA.

Vitamin B12 deficiencies are common in individuals consuming plant-predominant diets, including those who consume diary and/or eggs. Deficiencies can lead to megaloblastic anemia and peripheral neuropathy, among other multi-system manifestations. The prevalence, assessment and prevention of vitamin B12 deficiency in patients following plant-predominant diets will be discussed. Read More

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Whole-Exome Sequencing Revealed a Pathogenic Nonsense Variant in the SLC19A2 Gene in an Iranian Family with Thiamine-Responsive Megaloblastic Anemia.

Lab Med 2022 Jun 10. Epub 2022 Jun 10.

Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Objective: Solute carrier family 19 member 2 (SLC19A2, OMIM *603941) encodes thiamine human transporter 1 (THTR-1), which contributes to bringing thiamine (vitamin B1) into cells. Mutations in SLC19A2 lead to a rare recessive genetic disorder termed thiamine-responsive megaloblastic anemia (TRMA) syndrome.

Methods: An Iranian family with TRMA was investigated by whole-exome sequencing (WES) to determine the genetic cause(s) of the disease. Read More

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Parenteral vs Oral Vitamin B12 in Children With Nutritional Macrocytic Anemia: A Randomized Controlled Trial.

Indian Pediatr 2022 May 31. Epub 2022 May 31.

Department of Pediatrics, Pramukhswami Medical College, Bhaikaka University, Karamsad, Gujarat. Correspondence to: Dr Krutika Rahul Tandon, Professor and Head, Department of Pediatrics, Pramukhswami Medical College, Bhaikaka University, Karamsad 388 325, Dist. Anand (Gujarat).

Objective: Background: There is limited literature in children on efficacy of different routes of vitamin B12 administration for vitamin B12 deficiency macrocytic-megaloblastic anemia.

Objective: To compare parenteral with oral vitamin B12 therapy in children with macrocytic-megaloblastic anemia.

Study Design: Single-center, open-label randomized controlled trial. Read More

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Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance.

Clin Pharmacol Ther 2022 May 13. Epub 2022 May 13.

Department of Pharmaceutical Sciences, University of Toronto, Leslie Dan Faculty of Pharmacy, Toronto, Ontario, Canada.

During its fourth transporter workshop in 2021, the International Transporter Consortium (ITC) provided updates on emerging clinically relevant transporters for drug development. Previously highlighted and new transporters were considered based on up-to-date clinical evidence of their importance in drug-drug interactions and potential for altered drug efficacy and safety, including drug-nutrient interactions leading to nutrient deficiencies. For the first time, folate transport pathways (PCFT, RFC, and FRα) were examined in-depth as a potential mechanism of drug-induced folate deficiency and related toxicities (e. Read More

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Utility of reticulocyte indices in the diagnosis of pancytopenia.

J Family Med Prim Care 2022 Apr 18;11(4):1335-1340. Epub 2022 Mar 18.

Department of Pediatrics, NEIGRIHMS, Shillong, Meghalaya, India.

Introduction: Pancytopenia is a hematological condition in which there is a reduction in all three cell lines of blood. This study aims to evaluate the utility of reticulocyte indices such as reticulocyte % (retic %), immature reticulocyte fraction (IRF), and mean reticulocyte volume (MRV) in identifying the cause of pancytopenia.

Materials And Methods: Reticulocyte indices were measured by an automated coulter. Read More

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A novel TCN2 mutation with unusual clinical manifestations of hemolytic crisis and unexplained metabolic acidosis: expanding the genotype and phenotype of transcobalamin II deficiency.

BMC Pediatr 2022 04 29;22(1):233. Epub 2022 Apr 29.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama 6 Rd., Rajthewi, Bangkok, 10400, Thailand.

Background: Transcobalamin deficiency is a rare inborn metabolic disorder, characterized by pancytopenia, megaloblastic anemia, failure to thrive, diarrhea, and psychomotor retardation.

Case Presentation: We describe a patient who first presented at 3 months of age, with pancytopenia, hepatosplenomegaly, recurrent infection, metabolic acidosis, and acute hemolytic crisis. Extensive hematologic and immunologic investigations did not identify inherited bone marrow failure syndrome, acute leukemia or its related disorders. Read More

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Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis.

Front Immunol 2022 11;13:887256. Epub 2022 Apr 11.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Pernicious anemia (PA) is a megaloblastic anemia consisting of hematological, gastric and immunological alterations. The immunopathogenesis of PA is sustained by both autoantibodies (e.g. Read More

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Pernicious Anemia: The Hematological Presentation of a Multifaceted Disorder Caused by Cobalamin Deficiency.

Nutrients 2022 Apr 17;14(8). Epub 2022 Apr 17.

Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sant'Andrea Hospital, University Sapienza, 00189 Rome, Italy.

Pernicious anemia is still a neglected disorder in many medical contexts and is underdiagnosed in many patients. Pernicious anemia is linked to but different from autoimmune gastritis. Pernicious anemia occurs in a later stage of autoimmune atrophic gastritis when gastric intrinsic factor deficiency and consequent vitamin B deficiency may occur. Read More

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Effects of vitamin B12 supplementation on pain relief in certain diseases - a literature review.

Acta Biochim Pol 2022 Apr;69(2):265-271

Faculty of Medicine, Centre for Innovative Research in Medical and Natural Sciences, University of Rzeszów, Rzeszów Poland.

Based on current scientific reports, vitamin B12 (cobalamin), used in the treatment of pernicious anemia, may be used as a pain reliever. It has been shown to be effective in the treatment of different sorts of pain, including diabetic neuropathic, musculoskeletal, abdominal, back and spine ones, but also pain in Alzheimer's disease and pain ailments resulting from the development of neoplasms. In addition, it helps regeneration of the sensory nerves and relieves pain in eye diseases, for example in dry eye syndrome. Read More

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Absolute Neutrophil Count in Cases of Pancytopenia.

J Assoc Physicians India 2022 Apr;70(4):11-12

Army Hospital Research & Referral, New Delhi.

Pancytopenia is a common cause of hematological consultation. Common underlying causes include vitamin deficiency (vitamin B12, folic acid), drugs (hydroxyurea, phenytoin, methotrexate), and bone marrow failure syndrome. Aplastic anemia is one of the rarest hematological diseases and presents as pancytopenia. Read More

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Comment "Asymptomatic small intestinal ulcerative lesions: Obesity and are likely to be risk factors".

World J Gastroenterol 2022 Mar;28(10):1085-1087

Department of Obstetrics and Gynecology, Taizhou Women and Children's Hospital of Wenzhou Medical University, Taizhou 318000, Zhejiang Province, China.

There are many causes of anemia. It is unreasonable to simply associate anemia with asymptomatic ulcers in the small intestine. Read More

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Lutetium-177 Dotatate-Induced Hemolytic Anemia and Myelodysplastic Syndrome.

Cureus 2022 Feb 19;14(2):e22392. Epub 2022 Feb 19.

Pediatrics, Woodhull Medical Center, New York, USA.

Lutetium-177 (Lu) dotatate is a type of peptide receptor radioligand therapy (PRRT) using radiolabeled somatostatin for patients with progressive somatostatin receptor-positive gastrointestinal neuroendocrine tumors. While cases of therapy-related myeloid neoplasms (t-MN) have been described as a consequence of Lu dotatate, there are no reports of hemolytic anemia associated with therapy. We present a case of a 68-year-old woman with metastatic low-grade neuroendocrine tumor who presented four weeks after the second dose of Lu dotatate with progressive fatigue and dyspnea. Read More

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February 2022

COVID-19 fear-induced anorexia nervosa and obsessive-compulsive disorder leading to fatal megaloblastic anemia: Lethal psychological complication of the pandemic.

J Family Med Prim Care 2022 Feb 16;11(2):799-801. Epub 2022 Feb 16.

Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

We report a young female having severe pallor and breathlessness on presentation, being diagnosed as a case of megaloblastic anemia, which was confirmed on bone marrow biopsy. On detailed history taking, she was revealed to have anorexia nervosa precipitated due to extreme fear of COVID-19 along with obsessive-compulsive disorder. Thus, a psychiatric disorder presenting due to simple phobia of COVID-19 can also have a fatal outcome in the young. Read More

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February 2022

Atypical presentation of thiamine-responsive megaloblastic anemia in a Chinese baby boy.

Int J Lab Hematol 2022 Mar 31. Epub 2022 Mar 31.

Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.

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Visual Evoked Potentials in Patients With Vitamin B12 Deficiency.

J Clin Neurophysiol 2022 Jan 11. Epub 2022 Jan 11.

Departments of Neurology and Clinical Neurophysiology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.

Purpose: The aim of this study was to investigate the subclinical involvement of the optic nerve in asymptomatic patients with vitamin B12 deficiency using visual evoked potentials.

Methods: This study included 40 asymptomatic patients diagnosed with vitamin B12 deficiency (considered as serum levels below 150 pg/mL) and a control group of 40 healthy individuals. All participants underwent a visual evoked potential examination. Read More

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January 2022

Vitamin B12 deficiency.

Vitam Horm 2022 11;119:405-439. Epub 2022 Mar 11.

Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, United States.

Of the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. Read More

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Vitamin B12 absorption and malabsorption.

Vitam Horm 2022 1;119:241-274. Epub 2022 Mar 1.

Department of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine, St Louis, MO, United States. Electronic address:

Vitamin B12 is assimilated and transported by complex mechanisms that involve three transport proteins, intrinsic factor (IF), haptocorrin (HC) and transcobalamin (TC) and their respective membrane receptors. Vitamin deficiency is mainly due to inadequate dietary intake in vegans, and B12 malabsorption is related to digestive diseases. This review explores the physiology of vitamin B12 absorption and the mechanisms and diseases that produce malabsorption. Read More

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Pancytopenia Due to Vitamin B12 and Folic Acid Deficiency-A Case Report.

Pediatr Rep 2022 Mar 3;14(1):106-114. Epub 2022 Mar 3.

Department of Pediatrics, University Hospital Liège, Avenue de l'Hôpital 1, 4000 Liege, Belgium.

We report a case of severe pancytopenia in a 15-year-old patient due to a severe deficiency in vitamin B12 and folic acid, probably of nutritional origin. The clinical and biological course was favorable after vitamin supplementation. With this case, we discuss the diagnostic approach of pancytopenia with megaloblastic anemia in children and adolescents, as well as the mechanisms involved in vitamin B12 and B9 deficiency. Read More

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Paget's disease of bone and megaloblastic anemia in a 72-year-old patient: A case report and systematic literature review.

Exp Ther Med 2022 Apr 8;23(4):269. Epub 2022 Feb 8.

Department of Geriatrics and Gerontology, 'St. Apostle Andrei' Clinical Emergency County Hospital, 800578 Galați, Romania.

Paget's disease of bone (PDB) is characterized by abnormal osteoclastic bone resorption with disorganized bone neo-formation, primarily affecting elderly (>55 years) patients. Although the majority of patients are asymptomatic, some patients may experience bone pain due to local periosteal involvement or osteoarthritic lesions in the spine; in addition, limb deformities may lead to secondary gait problems or degenerative joint changes. Anemia has an overall prevalence of 12-17% in elderly adults (>65 years old), with macrocytic anemia being the less common type. Read More

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Clinico-hematological profile of pancytopenic adult patients in a tertiary care teaching hospital.

Tzu Chi Med J 2022 Jan-Mar;34(1):95-101. Epub 2021 Aug 23.

Department of Medicine, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

Objective: The causes of pancytopenia vary in different populations depending on age, gender, nutrition, geographic location, standard of living, and exposure to certain infections and drugs. As the severity of pancytopenia and its underlying etiology determine the management and prognosis, identifying the correct etiology in a given case is crucial and helps in implementing timely and appropriate treatment. The objectives of this study were to study the clinical profile and hematological parameters of pancytopenic adults and to identify different etiologies of pancytopenia. Read More

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Vitamin B12 Deficiency Resembling Acute Leukemia: A Case Report.

JNMA J Nepal Med Assoc 2021 Nov 15;59(243):1182-1184. Epub 2021 Nov 15.

Department of Pediatrics, Kanti Children's Hospital, Maharajganj, Kathmandu, Nepal.

Vitamin B12 deficiency in children can cause megaloblastic anemia, poor growth, and increased chances of infections. It is an important reversible cause of bone marrow suppression which at the time of presentation can mimic hematological malignancy. Therefore, it should be considered as a differential diagnosis in cases suspected of acute leukemia. Read More

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November 2021


Wiad Lek 2022 ;75(1 pt 2):164-171


Objective: The aim of this study: to determine the different causes of anemia among anemic women of reproductive age and to define associations between severity of anemia with different patient characteristics.

Patients And Methods: Materials and methods: This is a community based cross-sectional study that was conducted between October and December 2020 among a sample of anemic women at reproductive age between (14-49 years), who attended the private clinic in Baghdad city. The sample consisted of 120 participants (100 non-pregnant women and 20 pregnant women). Read More

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February 2022

Measurement for the Area of Red Blood Cells From Microscopic Images Based on Image Processing Technology and Its Applications in Aplastic Anemia, Megaloblastic Anemia, and Myelodysplastic Syndrome.

Front Med (Lausanne) 2021 25;8:796920. Epub 2022 Jan 25.

Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Aplastic anemia (AA), megaloblastic anemia (MA), and myelodysplastic syndrome (MDS) were common anemic diseases. Sometimes it was difficult to distinguish patients with these diseases.

Methods: In this article, we proposed one measurement method for the area of red blood cells (RBCs) from microscopic images based on image processing technology and analyzed the differences of the area in 25 patients with AA, 64 patients with MA, and 68 patients with MDS. Read More

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January 2022

Unusual presentation of stiff-person syndrome in a patient with type 1 diabetes mellitus.

BMJ Case Rep 2022 Feb 7;15(2). Epub 2022 Feb 7.

Mayo Clinic Hospital, Jacksonville, Florida, USA.

Stiff-person syndrome (SPS) is a rare, autoimmune, neurological disorder that often occurs concurrently with other autoimmune disorders, such as type 1 diabetes mellitus, pernicious anaemia, vitiligo and Hashimoto's thyroiditis. It also can manifest as a paraneoplastic syndrome. Although SPS classically presents with truncal and appendicular stiffness and lumbar hyperlordosis, it can present focally in a single limb (termed ). Read More

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February 2022

[Effect of Decitabine on Regulatory T Cells Relative Content in Peripheral Blood and Bone Marrow of Patients with Myelodysplastic Syndrome/Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2022 Feb;30(1):36-42

Department of Hematology, First Affiliated Hospital of Kunming Medical University, Hematology Research Center of Yunnan Province, Kunming 650032, Yunnan Province, China,E-mail:

Objective: To investigate regulatory T cells (Tregs) relative content in peripheral blood and bone marrow of patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) treated with or without decitabine (DAC), analyze the immunomodulatory of Tregs in pathogenesis and remission of MDS and AML, as well as effect of DAC on Tregs.

Methods: From October 2018 to February 2019, 15 patients with MDS and 49 patients with AML (newly diagnosed, treated with DAC or other chemotherapy regimens) were enrolled in this study, and 14 cases with iron deficiency or megaloblastic anemia while without malignant tumor and autoimmune disease as controls. The Tregs relative contents in bone marrow and peripheral blood were analyzed by flow cytometry, meanwhile clinical data of the objects were collected. Read More

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February 2022

Microcytic Anemia Hiding Vitamin B12 Deficiency Anemia.

Cureus 2021 Dec 27;13(12):e20741. Epub 2021 Dec 27.

Pediatric Hematology/Oncology, Maternity and Children Hospital, Ministry of Health, Al-Ahsa, SAU.

Vitamin B12 is an essential water-soluble vitamin that mediates multiple coenzymes needed for cell synthesis, mainly the red blood cells. Its deficiency is characterized by megaloblastic anemia and neuropsychiatric symptoms. Macrocytosis is the classical picture seen usually, but having microcytosis is unlikely. Read More

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December 2021