28,896 results match your criteria Anemia Chronic


Perioperative Lung Protective Ventilatory Management During Major Abdominal Surgery: A Hungarian Nationwide Survey.

J Crit Care Med (Targu Mures) 2019 Jan 4;5(1):19-27. Epub 2019 Feb 4.

University of Szeged, Department of Anaesthesiology and Intensive Therapy, Szeged, Hungary.

Lung protective mechanical ventilation (LPV) even in patients with healthy lungs is associated with a lower incidence of postoperative pulmonary complications (PPC). The pathophysiology of ventilator-induced lung injury and the risk factors of PPCs have been widely identified, and a perioperative lung protective concept has been elaborated. Despite the well-known advantages, results of recent studies indicated that intraoperative LPV is still not widely implemented in current anaesthesia practice. Read More

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http://dx.doi.org/10.2478/jccm-2019-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369570PMC
January 2019

[Quality of Life of Adolescents with Homozygous Sickle-Cell Disease Managed at the Brazzaville Teaching Hospital (Congo)].

Bull Soc Pathol Exot 2018 ;111(1):46-50

Service de pédiatrie nourrissons, CHU de Brazzaville, faculté des sciences de la santé, université Marien-Ngouabi, Brazzaville, BP 32, CG-Brazzaville, Congo.

Adolescence is a particular age group in terms of psychological and somatic changes. Thus, the experience of a chronic disease such as sickle-cell disease is different compared to the younger child who depends entirely on his parents. The purpose of this study is to assess the quality of life and to identify the determinants of good quality of life of such teenagers. Read More

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http://dx.doi.org/10.3166/bspe-2018-0006DOI Listing
January 2018

Chronic medical conditions in U.S. adults with incarceration history.

Authors:
Tomoko Udo

Health Psychol 2019 Mar;38(3):217-225

University at Albany, State University of New York.

Objectives: To examine the associations between incarceration history and chronic medical conditions in a nationally representative sample of U.S. adults and whether risk for chronic medical conditions differ by sex and race among those with incarceration history. Read More

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http://doi.apa.org/getdoi.cfm?doi=10.1037/hea0000720
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http://dx.doi.org/10.1037/hea0000720DOI Listing
March 2019
2 Reads

Clinical Features and Outcomes of Peripheral Vascular Disease Patients Receiving Red Blood Cell Transfusions.

Cureus 2018 Dec 4;10(12):e3682. Epub 2018 Dec 4.

Emergency Medicine, Charleston Area Medical Center, Charleston, USA.

Background Peripheral vascular disease (PVD) patients are commonly transfused with red blood cells (RBC) due to their inability to compensate for anemia and blood loss. Anemias, as well as allogeneic transfusions, have been demonstrated as independent risk factors for increased mortality and morbidity following cardiovascular procedures. The relationships between anemia, transfusion, and adverse outcomes in PVD patients remain unascertained and understudied. Read More

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http://dx.doi.org/10.7759/cureus.3682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367124PMC
December 2018

Association Between Norepinephrine Levels and Abnormal Iron Status in Patients With Chronic Heart Failure: Is Iron Deficiency More Than a Comorbidity?

J Am Heart Assoc 2019 Feb;8(4):e010887

3 Community Heart Failure Program Cardiology Department Bellvitge University Hospital Hospitalet de Llobregat Barcelona Spain.

Background Mechanisms underlying iron homeostasis dysregulation in patients with chronic heart failure remain unsettled. In cardiomyocyte models, norepinephrine may lead to intracellular iron depletion, but the potential association between catecholamines (sympathetic activation markers) and iron metabolism biomarkers in chronic heart failure is unknown. Methods and Results In this cross-sectional analysis, we studied the association between plasma norepinephrine levels and serum iron status biomarkers indicating iron storage (ferritin), iron transport (transferrin saturation), and iron demand (soluble transferrin receptor) in a prospective cohort of 742 chronic heart failure patients (mean age, 72±11 years; 56% male). Read More

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http://dx.doi.org/10.1161/JAHA.118.010887DOI Listing
February 2019

Psychiatric and medical correlates of DSM-5 eating disorders in a nationally representative sample of adults in the United States.

Int J Eat Disord 2019 Jan;52(1):42-50

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

Objective: To examine psychiatric and somatic correlates of DSM-5 eating disorders (EDs)-anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED)-in a nationally representative sample of adults in the United States.

Method: A national sample of 36,309 adult participants in the national epidemiologic survey on alcohol and related conditions III (NESARC-III) completed structured diagnostic interviews (AUDADIS-5) to determine psychiatric disorders, including EDs, and reported 12-month diagnosis of chronic somatic conditions. Prevalence of lifetime psychiatric disorders and somatic conditions were calculated across the AN, BN, and BED groups and a fourth group without specific ED; multiple logistic regression models compared the likelihood of psychiatric/somatic conditions with each specific ED relative to the no-specific ED group. Read More

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http://dx.doi.org/10.1002/eat.23004DOI Listing
January 2019

Pattern of Anaemia in Chronic Kidney Disease.

Mymensingh Med J 2019 Jan;28(1):1-7

Dr Mohammad Omar Faruque Miah, Senior Clinical Pathologist, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

The prevalence of chronic kidney disease (CKD) in Bangladesh is increasing. Chronic kidney disease refers to an irreversible deterioration in renal function which classically develops over a period of years. Initially, it manifest's only as a biochemical abnormality. Read More

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January 2019

Therapeutic targets for the anemia of predialysis chronic kidney disease: a meta-analysis of randomized, controlled trials.

J Investig Med 2019 Feb 11. Epub 2019 Feb 11.

Department of Nephrology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Anemia is one of the major complications in predialysis patients with chronic kidney disease (CKD). A clearer cognition of the prognostic impact of hemoglobin (Hb) or hematocrit (Hct) target on the outcomes of predialysis patients with CKD is significant. This article aims to establish the suitable hemoglobin target to provide clinical guidance. Read More

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http://dx.doi.org/10.1136/jim-2018-000915DOI Listing
February 2019

Automatic depletion with Spectra Optia allows a safe 16% reduction of red blood cell pack consumption in exchanged sickle cell anemia patients.

Transfusion 2019 Feb 12. Epub 2019 Feb 12.

Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Equipe "Biologie vasculaire et du globule rouge", Université Claude Bernard Lyon 1, COMUE Lyon, Villeurbanne, France.

Background: Chronic red blood cell exchanges (RBCXs) are frequently used to prevent complications in patients with sickle cell anemia, but the scarcity of matched red blood cell packs (RBCPs) is a serious concern. The main goal of this study was to compare the number of RBCPs used during RBCXs between the Spectra Optia (SO) device (with the automatic depletion step) and the former Cobe Spectra (CSP) device.

Study Design And Methods: The performances and safety of 300 SO sessions using the automatic depletion step (SO/DE) in 50 patients with sickle cell anemia under a chronic transfusion program over a 1-year period were prospectively analyzed. Read More

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http://dx.doi.org/10.1111/trf.15188DOI Listing
February 2019
1 Read

Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis.

Clin Kidney J 2019 Feb 19;12(1):139-148. Epub 2018 Mar 19.

Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, Collegeville, PA, USA.

Background: This study evaluated the hemoglobin dose response, other efficacy measures and safety of daprodustat, an orally administered, hypoxia-inducible factor prolyl hydroxylase inhibitor in development for anemia of chronic kidney disease.

Methods: Participants ( = 216) with baseline hemoglobin levels of 9-11.5 g/dL on hemodialysis (HD) previously receiving stable doses of recombinant human erythropoietin (rhEPO) were randomized in a 24-week dose-range, efficacy and safety study. Read More

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http://dx.doi.org/10.1093/ckj/sfy014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366140PMC
February 2019

Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants with chronic kidney disease.

Clin Kidney J 2019 Feb 9;12(1):129-138. Epub 2018 Mar 9.

Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, Collegeville, PA, USA.

Background: This study assessed the short-term safety and efficacy of daprodustat (an oral hypoxia-inducible factor-prolyl hydroxylase inhibitor) to achieve a target hemoglobin in patients with anemia of chronic kidney disease (CKD).

Methods: Patients ( = 252) with Stages 3-5 CKD not receiving dialysis were enrolled in this 24-week, multicenter trial [hemoglobin entry criteria: 8-10 g/dL (Cohort 1) or 8-11 g/dL (Cohort 2) for recombinant human erythropoietin (rhEPO)-naïve participants; 9-10.5 g/dL (Cohort 1) or 9-11. Read More

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https://academic.oup.com/ckj/article/12/1/129/4925438
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http://dx.doi.org/10.1093/ckj/sfy013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366145PMC
February 2019
1 Read

DYNAMO: A Phase II Study of Duvelisib (IPI-145) in Patients With Refractory Indolent Non-Hodgkin Lymphoma.

J Clin Oncol 2019 Feb 11:JCO1800915. Epub 2019 Feb 11.

19 University of Bologna, Bologna, Italy.

Purpose: Indolent non-Hodgkin lymphoma (iNHL) remains largely incurable and often requires multiple lines of treatment after becoming refractory to standard therapies. Duvelisib was approved by the Food and Drug Administration for relapsed or refractory (RR) chronic lymphocytic leukemia or small lymphocytic lymphoma (SLL) and RR follicular lymphoma (FL) after two or more prior systemic therapies. On the basis of the activity of duvelisib, a first-in-class oral dual inhibitor of phosphoinositide 3-kinase-δ,-γ, in RR iNHL in a phase I study, the safety and efficacy of duvelisib monotherapy was evaluated in iNHL refractory to rituximab and either chemotherapy or radioimmunotherapy. Read More

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http://dx.doi.org/10.1200/JCO.18.00915DOI Listing
February 2019
1 Read

Hemoglobin targets for the anemia in patients with dialysis-dependent chronic kidney disease: a meta-analysis of randomized, controlled trials.

Ren Fail 2018 Nov;40(1):671-679

a Department of Nephrology , The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.

Background: Anemia is extremely common among dialysis patients and underlies some of the symptoms associated with reduced kidney function, including fatigue, depression, reduced exercise tolerance, and dyspnea.

Objectives: A clearer cognition of the prognosistic impact of hemoglobin (Hb) or hematocrit (Hct) target for the outcomes of dialysis patients is urgent. This article aims to establish the suitable hemoglobin in order to provide clinical guidance. Read More

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http://dx.doi.org/10.1080/0886022X.2018.1532909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282462PMC
November 2018

Effect of atorvastatin on iron metabolism regulation in patients with chronic kidney disease - a randomized double blind crossover study.

Ren Fail 2018 Nov;40(1):700-709

a Department of Nephrology, Hypertension and Kidney Transplantation , Medical University of Lodz, University Hospital and Teaching Center , Lodz , Poland.

Introduction: To determine the effect of 6-month administration of atorvastatin on hepcidin and hemojuvelin levels, inflammatory parameters and iron metabolism in patients with chronic kidney disease (CKD) stages 3 and 4.

Methods: Thirty six statin- and erythropoiesis-stimulating agent-naive patients with CKD stages 3 and 4 and LDL cholesterol ≥100 mg/dl received atorvastatin or placebo for two 6-month periods in a double blind, randomized crossover study. Hepcidin, hemojuvelin, hsCRP, IL-6, hemoglobin, red blood cell distribution width, iron, total iron binding capacity (TIBC), and unsaturated iron binding capacity (UIBC) were measured before and after each treatment period. Read More

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http://dx.doi.org/10.1080/0886022X.2018.1535983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319462PMC
November 2018
1 Read

Circulating Microparticles in Children With Sickle Cell Anemia in a Tertiary Center in Upper Egypt.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619828839

6 Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt.

Sickle cell disease (SCD) is a genetically inherited hemolytic anemia increasingly appreciated as a chronic inflammatory condition and hypercoagulable state with high thrombotic risk. It is associated with disturbed immune phenotype and function and circulating microparticles (MPs) derived from multiple cell sources. This study was carried out to determine MPs profiles in patients with sickle cell anemia (either on hydroxyurea (HU) therapy or those with no disease-modifying therapy) and to compare these profiles with healthy children. Read More

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http://dx.doi.org/10.1177/1076029619828839DOI Listing
February 2019
1 Read
1.575 Impact Factor

Helicobacter pylori infection in children: an overview of diagnostic methods.

Eur J Clin Microbiol Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Islamic Republic of Iran.

Children differ from adults regarding Helicobacter pylori (H. pylori) infection in many terms. H. Read More

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http://link.springer.com/10.1007/s10096-019-03502-5
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http://dx.doi.org/10.1007/s10096-019-03502-5DOI Listing
February 2019
4 Reads

A different clinical presentation of Heiner syndrome: The case of diffuse alveolar hemorrhage causing massive hemoptysis and hematemesis.

Respir Med Case Rep 2019 23;26:206-208. Epub 2019 Jan 23.

Department of Pediatric, University of Health Sciences, Adana Health Practices and Research Center, Adana, Turkey.

Heiner syndrome is a non-IgE-mediated hypersensitivity to cow's milk, which often causes pulmonary disease in infants and young children. Patients often have symptoms of chronic or recurrent upper or lower respiratory tract infection. It has been reported that the Heiner's syndrome can cause recurrent pulmonary hemorrhage, and it is difficult to differentiate from the entity of idiopathic pulmonary hemosiderosis, another disease with recurrent pulmonary hemorrhage of unknown etiology usually occurring in the older children. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354653PMC
January 2019
1 Read

First molecular evidence of bovine hemoplasma species (Mycoplasma spp.) in water buffalo and dairy cattle herds in Cuba.

Parasit Vectors 2019 Feb 7;12(1):78. Epub 2019 Feb 7.

Clinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Background: Hemotropic mycoplasmas (aka hemoplasmas) are small bacteria which cause infectious anemia in several mammalian species including humans. Information on hemoplasma infections in Cuban bovines remains scarce and no studies applying molecular methods have been performed so far. The aim of the present study was to utilize real-time PCR and sequence analysis to investigate dairy cattle and buffalo from Cuba for the presence of bovine hemoplasma species. Read More

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http://dx.doi.org/10.1186/s13071-019-3325-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367761PMC
February 2019
1 Read

Chronic Lymphocytic Leukemia Presenting as a Subcortical Watershed Infarct.

Case Rep Hematol 2019 9;2019:2089359. Epub 2019 Jan 9.

Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.

Internal watershed infarcts (WI) involve white matter between deep and superficial arterial systems of middle cerebral artery. These infarcts are considered to be either from low blood flow or microembolism. Anemia is an extremely rare cause of watershed infarcts. Read More

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https://www.hindawi.com/journals/crihem/2019/2089359/
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http://dx.doi.org/10.1155/2019/2089359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343168PMC
January 2019
3 Reads

[Successful treatment of pure red cell aplasia with cyclosporin in a patient with T-cell large granular lymphocytic leukemia harboring the STAT3 D661V mutation].

Rinsho Ketsueki 2019 ;60(1):39-45

Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University.

T-cell large granular lymphocyte (T-LGL) leukemia is a chronic T-cell monoclonal disease that is occasionally associated with pure red cell aplasia (PRCA). A 71-year-old previously healthy man complained of physical fatigue and exhibited anemia (hemoglobin, 10.5 g/dl) with lymphocytosis (76%) showing LGL. Read More

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http://dx.doi.org/10.11406/rinketsu.60.39DOI Listing
January 2019
1 Read

Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS.

Ann Am Thorac Soc 2018 Jun;15(6):710-717

1 Division of Pulmonary and Critical Care Medicine, Department of Medicine and.

Rationale: Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and associated with a significant burden of comorbidities. Although anemia is associated with adverse outcomes in COPD, its contribution to outcomes in individuals with other comorbid chronic diseases is not well understood.

Objectives: This study examines the association of anemia with outcomes in a large, well-characterized COPD cohort, and attempts to understand the contribution of anemia to outcomes and phenotypes in individuals with other comorbidities. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201708-687OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207135PMC
June 2018
1 Read

[Evolution of aplastic anemia in a patient on chronic hemodialysis. Sixteen years later…].

Authors:
Jorge Vega Stieb

Rev Med Chil 2018 Sep;146(9):1085

Departamento de Medicina, Escuela de Medicina, Universidad de Valparaíso, Chile.

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http://dx.doi.org/10.4067/s0034-98872018000901085DOI Listing
September 2018

A Unique Case of Severe Anemia Secondary to Copper Deficiency in an Adult Patient.

Cureus 2018 Nov 26;10(11):e3636. Epub 2018 Nov 26.

Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA.

Anemia is a frequently encountered problem in the healthcare system. Common causes of anemia include blood loss, followed by impaired red blood cell production and red blood cell destruction. This case demonstrates the need for cognizance of the less frequent causes of anemia. Read More

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http://dx.doi.org/10.7759/cureus.3636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351007PMC
November 2018

Association between trace element concentrations and anemia in patients with chronic kidney disease: a cross-sectional population-based study.

J Investig Med 2019 Feb 4. Epub 2019 Feb 4.

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.

Anemia is common in chronic kidney disease (CKD) and may be affected by trace element concentrations. While the concentrations of trace elements are known to be altered in CKD, the relationship between trace element and hemoglobin concentrations has not been systematically investigated in a large cohort. This study aims to examine associations between trace element concentrations and anemia in patients with CKD. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000833
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http://dx.doi.org/10.1136/jim-2018-000833DOI Listing
February 2019
1 Read

Tuberculosis-associated anemia is linked to a distinct inflammatory profile that persists after initiation of antitubercular therapy.

Sci Rep 2019 Feb 4;9(1):1381. Epub 2019 Feb 4.

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.

Pulmonary tuberculosis (PTB) is associated with chronic inflammation and anemia. How anemia impacts systemic inflammation in PTB patients undergoing antitubercular therapy (ATT) is not fully understood. In the present study, data on several blood biochemical parameters were retrospectively analyzed from 118 PTB patients during the first 60 days of ATT. Read More

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http://dx.doi.org/10.1038/s41598-018-37860-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361962PMC
February 2019
1 Read

Investigation of occupational exposure to lead and its relation with blood lead levels in electrical solderers.

Environ Monit Assess 2019 Feb 4;191(3):126. Epub 2019 Feb 4.

Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.

Occupational exposure to lead compounds can cause headache, nausea, encephalopathy, anemia, chronic muscle pain, and saturnism. Exposure to lead in women can affect fertility, and cause abortion or low IQ in the offspring. The aim of this study was to investigate occupational exposure to lead and its relation with blood lead levels in female electrical parts solderers. Read More

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http://link.springer.com/10.1007/s10661-019-7258-x
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http://dx.doi.org/10.1007/s10661-019-7258-xDOI Listing
February 2019
2 Reads

The link between anemia and adverse outcomes in patients with acute coronary syndrome.

Expert Rev Cardiovasc Ther 2019 Feb 4. Epub 2019 Feb 4.

a The Zena and Michael A. Weiner Cardiovascular Institute , The Icahn School of Medicine at Mount Sinai , New York , Unites States.

Introduction: Anemia is one of the most frequent comorbidities in acute coronary syndrome (ACS) patients and is associated with a significant impact on clinical outcomes. This review summarizes the knowledge and updated management of anemia in the setting of ACS. Areas covered: We provide a review on the prevalence, pathophysiology, prognosis, impact, and updated management of anemia. Read More

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http://dx.doi.org/10.1080/14779072.2019.1575729DOI Listing
February 2019
1 Read

Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria in the Age of Eculizumab.

Biol Blood Marrow Transplant 2019 Jan 31. Epub 2019 Jan 31.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Medical Oncology, Department of Medicine. Electronic address:

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired clonal hematopoietic cell disease characterized by destruction of hematopoietic cells through the activation of the complement system with manifestations that can be life threatening including hemolysis, thrombosis, and marrow failure. Allogeneic hematopoietic cell transplantation (HCT) remains the only cure for PNH, but eculizumab, a terminal complement inhibitor of C5, has been used to prevent complement mediated hemolysis in PNH since its FDA approval in 2007. We examined outcomes of HCT in PNH patients to evaluate the effects of disease subtype, conditioning intensity, and eculizumab use either pre- or post-HCT. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.01.033DOI Listing
January 2019
2 Reads

Comorbidity assessment for mortality risk stratification in elderly patients with acute coronary syndrome.

Eur J Intern Med 2019 Jan 31. Epub 2019 Jan 31.

Servei de Cardiologia, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Background: The Charlson's is the most used comorbidity index. It comprises 19 comorbidities, some of which are infrequent in elderly patients with acute coronary syndrome (ACS), while some others are manifestations of cardiac disease rather than comorbidities. Our goal was to simplify comorbidity assessment in elderly non-ST-segment elevation ACS patients. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.018DOI Listing
January 2019
1 Read

GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice.

Cancer Sci 2019 Feb 2. Epub 2019 Feb 2.

Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.

The transcription factor GATA2 regulates normal hematopoiesis, particularly in stem cell maintenance and myeloid differentiation. Various heteroallelic GATA2 gene mutations are associated with a variety of hematological neoplasms, including myelodysplastic syndromes and leukemias. Here, we report that impaired GATA2 expression induces myelodysplastic and myeloproliferative neoplasm development in elderly animals, and this neoplasm resembles chronic myelomonocytic leukemia in humans. Read More

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http://doi.wiley.com/10.1111/cas.13959
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http://dx.doi.org/10.1111/cas.13959DOI Listing
February 2019
12 Reads

Massive Hemoptysis Due to the Rupture of Thoracic Aortic Aneurysm Caused by Leukemic Cell Infiltration in a Patient With Chronic Myelomonocytic Leukemia.

J Clin Med Res 2019 Feb 5;11(2):145-150. Epub 2019 Jan 5.

Department of Clinical Pathology, Asahi General Hospital, Chiba, Japan.

Hemoptysis is occasionally experienced in patients with hematological malignancies who have respiratory tract infection and severe thrombocytopenia. Thrombocytopenia due to hematological disease is one cause of hemoptysis. Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy characterized by both a myeloproliferative neoplasm and a myelodysplastic syndrome. Read More

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http://dx.doi.org/10.14740/jocmr3712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340676PMC
February 2019
1 Read

Intestinal Spirocheteosis in a Patient with Celiac Disease.

J Coll Physicians Surg Pak 2019 Feb;29(2):173-174

Department of Hepato-Gastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.

A young girl presented to us with recurrent diarrhea along with a history of 5 kg weight loss in one year. On examination, she appeared pale, while her laboratory reports showed a low hemoglobin, mean corpuscular volume (MCV) and serum albumin. Her erythrocyte sedimentation rate (ESR) was slightly raised with her iron profile suggestive of iron deficiency anemia. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.02.173DOI Listing
February 2019
2 Reads

Anemia and Iron Deficiency in Children with Chronic Kidney Disease (CKD): Data from the Know-Ped CKD Study.

J Clin Med 2019 Jan 29;8(2). Epub 2019 Jan 29.

Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul 03722, Korea.

Children with chronic kidney disease (CKD) are at high risk of anemia, an important risk factor for cardiovascular disease and poor quality of life. The present study used baseline data from the Korean cohort study for Outcome in patients With Pediatric Chronic Kidney Disease (KNOW-PedCKD). A Total of 437 patients was included in the analyses excluding missing data. Read More

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http://dx.doi.org/10.3390/jcm8020152DOI Listing
January 2019
4 Reads

A Placebo-Controlled, Randomized Trial of Enarodustat in Patients with Chronic Kidney Disease Followed by Long-Term Trial.

Am J Nephrol 2019 30;49(2):165-174. Epub 2019 Jan 30.

Fukuoka Renal Clinic, Fukuoka, Japan.

Background: Enarodustat (JTZ-951) is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that mimics adaptive responses to hypoxic conditions and may provide a new therapeutic approach for managing anemia in patients with chronic kidney disease (CKD). We evaluated the efficacy, safety, and maintenance dose of enarodustat in anemic patients with CKD not on dialysis.

Methods: Erythropoiesis-stimulating agent (ESA) naïve patients (correction group) and patients on a stable dose of ESA (conversion group) were randomized to receive 2, 4, or 6 mg of enarodustat or placebo once daily for 6 weeks in a double-blind manner (Period 1) followed by 24 weeks of open enarodustat treatment to maintain their hemoglobin (Hb) levels within a target range of 10. Read More

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https://www.karger.com/Article/FullText/496929
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http://dx.doi.org/10.1159/000496929DOI Listing
January 2019
2 Reads

Vitamin D deficiency and anemia is highly prevalent and dependent on the etiology of heart failure: A pilot study.

Cardiol J 2019 Jan 30. Epub 2019 Jan 30.

Department of Invasive Cardiology, Medical University of Bialystok, Poland, Bialystok, Poland.

Background: Anemia and vitamin D deficiency are common factors in chronic heart failure (CHF). The aim of this study was to assess vitamin D levels as well as its binding protein and anemia in relation to a cause of CHF: coronary heart disease, valvular disease and cardiomyopathy.

Methods: 116 consecutive patients (36 females and 80 males) with CHF were admitted for percutaneous coronary interventions (PCI). Read More

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http://dx.doi.org/10.5603/CJ.a2019.0003DOI Listing
January 2019

A human mode of intestinal type gastric carcinoma.

Authors:
Shaoqing Lai

Med Hypotheses 2019 Feb 14;123:27-29. Epub 2018 Dec 14.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address:

Gastric cancer is a malignant tumor originating from the gastric mucosa epithelium. Intestinal type gastric cancer is frequently taken on elderly men, and there are many high incidence areas around the world. Intestinal type gastric cancer often is accompanied by gastric mucosal atrophy, intestinal metaplasia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183121
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http://dx.doi.org/10.1016/j.mehy.2018.12.009DOI Listing
February 2019
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Differences between intravenous iron products: focus on treatment of iron deficiency in chronic heart failure patients.

ESC Heart Fail 2019 Jan 29. Epub 2019 Jan 29.

Centre for Heart Diseases - Clinical Military Hospital, Wroclaw, Poland.

Iron deficiency is the leading cause of anaemia and is highly prevalent in patients with chronic heart failure (CHF). Iron deficiency, with or without anaemia, can be corrected with intravenous (i.v. Read More

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http://dx.doi.org/10.1002/ehf2.12400DOI Listing
January 2019

Sudden intraoperative pulmonary congestion in a patient with severe anemia transfused 3 days prior to surgery.

Saudi J Anaesth 2019 Jan-Mar;13(1):69-71

Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Preoperative blood transfusion is sometimes controversial. We describe a case of a 43-year-old woman who developed sudden pulmonary congestion during surgery despite a small amount of intravenous crystalloid administration. She had no allergic disorders. Read More

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http://dx.doi.org/10.4103/sja.SJA_468_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329250PMC
January 2019

Predicting Postoperative Destination Through Preoperative Evaluation in Elective Open Aortic Aneurysm Repair.

J Surg Res 2019 Mar 26;235:543-550. Epub 2018 Nov 26.

Division of Vascular and Endovascular Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: There are limited data guiding preoperative counseling on the need for discharge to facility after elective open abdominal aortic aneurysm repair (OAR). This study aims to determine the preoperative predictors for nonhome discharge (NHD) following OAR.

Materials And Methods: The National Surgical Quality Improvement Program Vascular Procedure Targeted database was queried for elective OAR, 2011-2015. Read More

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http://dx.doi.org/10.1016/j.jss.2018.10.039DOI Listing
March 2019
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Clonal hematopoiesis: Pre-cancer PLUS.

Adv Cancer Res 2019 14;141:85-128. Epub 2019 Jan 14.

Department of Pathology, Stanford University, Stanford, CA, United States. Electronic address:

Clonal hematopoiesis is a common, age-related process in which a somatically mutated hematopoietic precursor gives rise to a genetically distinct subpopulation in the blood. This phenomenon has been observed in populations across the globe and, while virtually non-existent in children is estimated to affect >10% of the 70-and-older age group. The mutations are thought to occur in stem cells, which makes them pre-cancerous, and precursors to cancer stem cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0065230X183007
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http://dx.doi.org/10.1016/bs.acr.2018.12.003DOI Listing
January 2019
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Chronic Basophilic Leukaemia in a Dog.

J Comp Pathol 2019 Jan 27;166:5-8. Epub 2018 Nov 27.

Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan. Electronic address:

A 13-year-old neutered female mixed-breed dog with a clinical history of emaciation, inappetence and vomiting for 2 months was presented. Blood tests showed marked leucocytosis with increased neutrophil and basophil count, mild thrombocytosis and anaemia. Seven days after the initial visit, the dog died and was submitted for necropsy examination. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219975183003
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http://dx.doi.org/10.1016/j.jcpa.2018.10.170DOI Listing
January 2019
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Erythropoiesis-Stimulating Agents in the Management of Anemia in Chronic Kidney Disease or Cancer: A Historical Perspective.

Front Pharmacol 2018 9;9:1498. Epub 2019 Jan 9.

Division of Nephrology, Indiana University Health, Indianapolis, IN, United States.

Anemia is common in patients with cancer or with chronic kidney disease (CKD). Although the introduction of erythropoiesis-stimulating agents (ESAs) has transformed the management of anemia, their use has been complicated by a number of factors including frequent guideline updates, safety concerns and, in the United States, a Risk Evaluation and Mitigation Strategy (REMS) program, which aimed to ensure that the benefits of ESAs outweigh the risks. Many previous concerns around ESA use in cancer and CKD have been addressed by the reassuring results of post-approval studies, and biosimilar ESAs have been used in Europe for many years, with safety and efficacy profiles similar to originator products. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2018.01498
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http://dx.doi.org/10.3389/fphar.2018.01498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333861PMC
January 2019
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Association between MTHFR 677C>T polymorphism and vascular complications in sickle cell disease: A meta-analysis.

Transfus Clin Biol 2019 Jan 10. Epub 2019 Jan 10.

Sickle Cell Institute Chhattisgarh, Forest Block-2, Jail Road, Raipur 492001, Chhattisgarh India. Electronic address:

Sickle cell disease (SCD) is considered as a vascular disease due to its chronic vascular manifestations such as leg ulcers, priapism, acute chest syndrome (ACS), stroke, retinopathy, renal insufficiency, pulmonary hypertension, avascular necrosis of the femoral head (AVNF) and splenic infarction. Emerging evidence has shown that the MTHFR 677C>T variant allele is associated with vascular complications (VC) in patients with SCD; however, results from individual studies are inconclusive. The aim of this meta-analysis is to evaluate the association between the MTHFR 677C>T polymorphism and the susceptibility for VC in SCD patients. Read More

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http://dx.doi.org/10.1016/j.tracli.2019.01.003DOI Listing
January 2019
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Aneurysm sac failure to regress after endovascular aneurysm repair is associated with lower long-term survival.

J Vasc Surg 2019 Feb 28;69(2):414-422. Epub 2018 Jun 28.

Division of Vascular Surgery and Endovascular Interventions, NewYork-Presbyterian/Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY. Electronic address:

Background: The early survival advantage of endovascular aneurysm repair (EVAR) compared with open repair reverses over time, possibly because of higher rates of reintervention related to endoleaks and aneurysm sac expansion. Therefore, we sought to examine the association between sac behavior, endoleaks, reintervention, and long-term survival.

Methods: We reviewed all patients undergoing EVAR in the Vascular Quality Initiative between 2003 and 2017 with an imaging study at 1 year postoperatively (±6 months). Read More

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http://dx.doi.org/10.1016/j.jvs.2018.04.050DOI Listing
February 2019
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Upregulation of endogenous erythropoietin expression by DLBS6747, a bioactive fraction of Ipomoea batatas L. leaves, via increasing HIF1α transcription factor in HEK293 kidney cells.

J Ethnopharmacol 2019 Jan 24;235:190-198. Epub 2019 Jan 24.

Dexa Laboratories of Biomolecular Sciences (DLBS), Industri Selatan V Block PP No. 7, Jababeka Industrial Estate II, Cikarang 17550, West Java, Indonesia. Electronic address:

Ethnopharmacological Relevance: Ipomoea batatas L., locally known as ubi jalar, is widely used in Indonesia and other countries as a folk remedy for various chronic diseases, including anemia-associated chronic kidney disease by increasing hematological parameters such as packed cell volume, white blood cells and platelet counts.

Aim Of The Study: The aim of this study is to evaluate the effect of DLBS6747, a bioactive fraction of I. Read More

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http://dx.doi.org/10.1016/j.jep.2019.01.016DOI Listing
January 2019
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Congenital erythropoietic porphyria: Recent advances.

Mol Genet Metab 2018 Dec 27. Epub 2018 Dec 27.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America. Electronic address:

Congenital erythropoietic porphyria (CEP) is a rare autosomal recessive disorder characterized by photosensitivity and by hematologic abnormalities in affected individuals. CEP is caused by mutations in the uroporphyrinogen synthase (UROS) gene. In three reported cases, CEP has been associated with a specific X-linked GATA1 mutation. Read More

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http://dx.doi.org/10.1016/j.ymgme.2018.12.008DOI Listing
December 2018
4 Reads