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J Assoc Physicians India 2022 May;70(5):11-12

Professor & Head, Department of Medicine, Mount Zion Medical College, Chayalode, Kerala.

This report describes a case of Autoimmune Hemolytic Anemia that was possibly induced by COVID-19 in a patient with history of Chronic Liver Disease and Diabetes Mellitus. Autoimmune responses like hemolytic anemia are known to be triggered by viral infections. COVID-19 is reported to be inducing Autoimmune Hemolytic Anemia in susceptible individuals. Read More

J Relig Health 2022 May 20. Epub 2022 May 20.

Division of Heart Surgery, University of Campania Luigi Vanvitelli, Naples, Italy.

The purpose of this study is to explore the historical background of edema as a prognostic sign in popes, a special category of medical subjects whose health status was closely monitored and chronicled because of their unique important status in the events of their times. Nine out of 51 popes, who reigned in the years 1555-1978, died edematous at a mean age of 75.5 years of age. Read More

Chemosphere 2022 May 17:134977. Epub 2022 May 17.

Department of Nature Conservation, Tshwane University of Technology, South Africa.

Lead (Pb) exposure is a widespread wildlife conservation threat, but impacts on reptile populations remain poorly documented. In this study, we examined Pb exposure and accumulation in a wild population of Nile crocodiles (Crocodylus niloticus) at Lake St Lucia, South Africa. Recreational angling has occurred in the area since the 1930s and incidental ingestion of Pb fishing weights has previously been identified as a major source of Pb poisoning in the local crocodile population. Read More

Am Surg 2022 May 20:31348221104252. Epub 2022 May 20.

Department of Surgery and Sepsis and Critical Illness Research Center, 3463University of Florida Health, Gainesville, FL, USA.

Introduction: Survivors of sepsis will progress towards rapid recovery (RAP) or enter a state of persistent organ dysfunction and chronic critical illness (CCI). Independently, anemia is known to be a significant factor in functional recovery of hospitalized patients. This study aims to analyze long-term hemoglobin levels and functional outcomes following RAP and CCI. Read More

Best Pract Res Clin Obstet Gynaecol 2022 Mar 30. Epub 2022 Mar 30.

University Medical Center Hamburg-Eppendorf, Department of Obstetrics and Fetal Medicine, Hamburg, Germany.

In twin-to-twin transfusion syndrome (TTTS) communicating placental vessels on the chorionic plate between the donor and recipient twins are responsible for the chronic imbalance of blood flow. Evidence demonstrates that fetoscopic laser ablation is superior to serial amnioreductions in terms of survival and neurological outcome for stages II-IV TTTS. However, the optimal management of stage I TTTS remains poorly understood. Read More

Oncologist 2022 May 19. Epub 2022 May 19.

Section of Digestive Diseases, Yale School of Medicine, New Haven, CT, USA.

Background: Microangiopathic hemolytic anemia (MAHA) is a rare paraneoplastic syndrome that has been reported in patients with gastric signet ring cell carcinoma (SRCC). Clinical and prognostic features of MAHA in this setting have been poorly described.

Materials And Methods: We conducted a systematic review in 8 databases of gastric SRCC complicated by MAHA and performed a case-control study assessing factors associated with survival in patients with gastric SRCC and MAHA in our pooled cohort compared with age-, sex-, and stage-matched cases of gastric SRCC from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

Blood 2022 May;139(20):3030-3039

Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; and.

Chronic hemolytic anemia and intermittent acute pain episodes are the 2 hallmark characteristics of sickle cell disease (SCD). Anemia in SCD not only signals a reduction of red cell mass and oxygen delivery, but also ongoing red cell breakdown and release of cell-free hemoglobin, which together contribute to a number of pathophysiological responses and play a key role in the pathogenesis of cumulative multiorgan damage. However, although anemia is clearly associated with many detrimental outcomes, it may also have an advantage in SCD in lowering risks of potential viscosity-related complications. Read More

Clin Interv Aging 2022 11;17:767-776. Epub 2022 May 11.

Department of Surgery, Amphia Hospital, Breda, the Netherlands.

Objective: Chronic limb threatening ischemia is the final stage of peripheral arterial disease. Current treatment is based on revascularization to preserve the leg. In the older, hospitalized chronic limb threatening ischemia patient, delirium is a frequent and severe complication after revascularization. Read More

J Multimorb Comorb 2022 22;12:26335565221076254. Epub 2022 Feb 22.

Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany.

Background: Multimorbidity poses an increasing challenge to health care systems in Sub-Saharan Africa. We studied the extent of multimorbidity and patterns of comorbidity among women aged 40 years or older in a peri-urban area of Dar es Salaam, Tanzania.

Methods: We assessed 15 chronic conditions in 1528 women who participated in a cross-sectional survey that was conducted within the Dar es Salaam Urban Cohort Study (DUCS) from June 2017 to July 2018. Read More

Clin Med (Lond) 2022 May;22(3):218-220

University Hospitals Sussex NHS Foundation Trust, Brighton, UK and Brighton and Sussex Medical School, Falmer, UK.

Sickle cell disease is a common inherited disorder that is characterised by chronic haemolysis and vaso-occlusive episodes, resulting in severe pain and end-organ damage. The most frequent acute manifestation of sickle cell disease is a painful vaso-occlusive crisis, which can, in some cases, develop into a sickle chest crisis: a life-threatening complication of sickle cell disease that requires early recognition and prompt intervention to prevent progressive respiratory failure. In addition to the acute complications, patients with sickle cell disease are also at risk of a number of chronic complications that require multidisciplinary specialist input. Read More

Rev Esp Med Nucl Imagen Mol (Engl Ed) 2022 May-Jun;41(3):138-145. Epub 2021 Apr 15.

Medical University Innsbruck, Department of Nuclear Medicine, Austria.

Purpose: Nephro- and hematotoxicity after peptide receptor radionuclide therapy (PRRT) have been described in multiple studies with heterogeneous cumulative activities, number of cycles or radiolabelled peptides. Though highly differentiated metastasized neuroendocrine tumours (NET) have long progression free survival, they may progress. We analysed long-term side effects in a homogenous treatment schedule in PRRT-patients and their impact on future oncologic treatment in case of progression. Read More

Curr Probl Cardiol 2022 May 13:101251. Epub 2022 May 13.

New York Medical College at Westchester Medical Center, New York, NY, USA. Electronic address:

Introduction: There have been no studies focusing on how pulmonary hypertension (PH) affects inpatient outcomes in patients with hypertrophic cardiomyopathy (HCM) hospitalized for acute decompensated heart failure or cardiogenic shock. This study explores inpatient outcomes of patients with HCM, and concomitant PH compared to patients with HCM.

Methods: Based on the National Inpatient Sample (NIS) 2016-2018, patients admitted with a primary diagnosis of acute decompensated heart failure or cardiogenic shock were selected. Read More

Aten Primaria 2022 May 13;54(7):102357. Epub 2022 May 13.

Unidad de Investigación, Área de Salud Don Benito-Villanueva, Servicio Extremeño de Salud, Villanueva de la Serena, Badajoz, España; Centro de Salud Mérida Urbano I, Mérida, Badajoz, España.

Aim: To study the evolution of the clinical profile of a population discharged with a main diagnosis of heart failure (HF) in the first two decades of the century and the predictive variables of mortality and readmission in the first year of discharge.

Design: Observational, retrospective, longitudinal study. SITE: Don Benito Villanueva de la Serena Badajoz health area. Read More

J Hematol 2022 Apr 12;11(2):55-61. Epub 2022 Apr 12.

Digestive Diseases and Nutrition Department, University of Kentucky, Lexington, KY, USA.

Background: There are few studies to evaluate the association between iron deficiency anemia (IDA) and Crohn's disease (CD). We examined this association in a USA-based cohort of patients with CD.

Methods: We queried the Nationwide Readmission Databases 2018 using the International Classification of Disease, 10th Revision, and Clinical Modification (ICD-10-CM) codes to identify all adult patients admitted with a diagnosis of CD. Read More

Cureus 2022 Apr 12;14(4):e24064. Epub 2022 Apr 12.

Department of Internal Medicine, Dr. Ruth K. M. Pfau Civil Hospital Karachi, Karachi, PAK.

Behcet's disease (BD), also known as Behcet's syndrome, is a rare, chronic, autoimmune disorder of unknown origin. Its manifestations are thought to be caused by vasculitis, resulting in damage to blood vessels of all sizes throughout the body. We report a 25-year-old Pakistani male who is sexually active and presents with a one-year history of shortness of breath, cough, exertional dyspnea, and neck and facial swelling. Read More

Case Rep Hematol 2022 4;2022:4628183. Epub 2022 May 4.

School of Medicine, University of Virginia, Charlottesville, Virginia, USA.

Atypical chronic myeloid leukemia (aCML) is a rare myeloproliferative disorder that shares clinical features with chronic myeloid leukemia but lacks the classic t(9;22) translocation and features prominent dysgranulopoiesis and granulocytic dysplasia. Challenges of this diagnosis include clinical and biologic heterogeneity, the high risk of transformation to acute myeloid leukemia, and the lack of standard treatment options. Allogeneic hematopoietic stem cell transplant is likely the preferred treatment, but this can be limited by patient psychosocial support, age, concomitant medical conditions, and availability of an appropriate donor. Read More

J Oral Maxillofac Pathol 2022 Jan-Mar;26(1):77-81. Epub 2022 Mar 31.

Department of Oral and Maxillofacial Pathology and Microbiology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.

Background: Bacteria and their products involved in periodontitis evoke an immunoinflammatory response in the host tissue. Inflammatory diseases, such as periodontitis, are often not just a local event, but may have systemic ramifications, including elevations in the numbers of circulating leukocytes, acute-phase proteins and oxidative stress markers. It is now emerging that also erythrocytes are affected by chronic inflammatory diseases. Read More

Curr Res Pharmacol Drug Discov 2022 30;3:100102. Epub 2022 Apr 30.

Department of Pharmacology and Toxicology, Zydus Research Centre, Cadila Healthcare Limited, Sarkhej Bavla NH 8A, Moraiya, Ahmedabad, Gujarat, India.

Many anemic chronic kidney disease (CKD) patients are refractory to erythropoietin (EPO) effects due to inflammation, deranged iron utilization, and generation of EPO antibodies. This work assessed the effect of desidustat, an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase (PHD), on EPO-refractory renal anemia. Sprague Dawley rats were made anemic by cisplatin (5 ​mg/kg, IP, single dose) and turpentine oil (5 ​mL/kg, SC, once a week). Read More

J Yeungnam Med Sci 2022 May 16. Epub 2022 May 16.

Department of Periodontology, Sibar Institute of Dental Sciences, Guntur, India.

Background: Chronic infectious, inflammatory, or neoplastic disorders are associated with anemia of chronic disease. Chronic inflammatory diseases such as periodontitis may contribute to masked anemia, especially in smokers. This study was aimed at verifying and comparing the efficacy of nonsurgical periodontal therapy (NSPT) for improving anemia among chronic periodontitis patients with and without the habit of smoking. Read More

ESC Heart Fail 2022 May 15. Epub 2022 May 15.

Department of Medicine, Division of Cardiology, Orlando Health, Orlando, FL, USA.

Aims: Temporal conversions among ejection fraction (EF) classes can occur across the heart failure (HF) spectrum reflecting amended structural and functional outcomes unaccounted for by current taxonomy. This retrospective study aims to investigate the differences in serum laboratory values, guideline-directed medical therapy (GDMT), and co-morbidityburden across EF conversion groups.

Methods And Results: Heart failure patients at least 18-year-old who obtained at least two echocardiograms between January 2018 and January 2020 were identified using ICD-10 codes. Read More

Kardiologiia 2022 Apr 30;62(4):30-35. Epub 2022 Apr 30.

Medical Research and Educational Center, Lomonosov Moscow State University; Faculty of Fundamental Medicine, Lomonosov Moscow State University.

Aim    To test a hypothesis that increased values of red cell distribution width (RDW) in patients with chronic heart failure (CHF) can be related with low exercise tolerance.Material and methods    102 patients were evaluated who had CHF with mid-range and reduced left ventricular ejection fraction (LV EF) without anemia (72% men, mean age 66±10.2 years). Read More

BMC Surg 2022 May 14;22(1):183. Epub 2022 May 14.

Department of Gastroenterology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, 1 Zhongfu Road, Nanjing, Jiangsu, China.

Background: Previous studies reported that transnasal ileus tube was a new and useful method for rapid relief of small intestinal obstruction. However, no study reported the impacts of the transnasal ileus tube for Crohn's disease combined with intestinal obstruction. We aimed to describe the strategy to the small intestine obstruction caused by Crohn's disease on the basis of transnasal ileus tube insertion. Read More

Br J Haematol 2022 May 14. Epub 2022 May 14.

Centre for Lymphoid Cancer and Division of Medical Oncology, BC Cancer, University of British Columbia, Vancouver, British Columbia, Canada.

Hodgkin variant Richter transformation (HvRT) is a rare and challenging complication of chronic lymphocytic leukaemia (CLL) for which information on prognostic factors and treatment approaches remain limited. We analysed characteristics and survival outcomes of a population-based cohort of 32 patients with HvRT identified in British Columbia over a 40-year period. Median interval from CLL diagnosis to HvRT was 5. Read More

Int J Environ Res Public Health 2022 May 7;19(9). Epub 2022 May 7.

Division of Nephrology, Department of Medicine, Armed Forces Taoyuan General Hospital, Taoyuan 325, Taiwan.

Each patient undergoing maintenance haemodialysis (MHD) has a different response to erythropoiesis-stimulating agents (ESAs). Haemodilution due to fluid overload has been shown to contribute to anaemia. Body mass index (BMI) has been shown to influence ESA response in dialysis patients; however, BMI calculation does not distinguish between fat and lean tissue. Read More

Int J Environ Res Public Health 2022 Apr 20;19(9). Epub 2022 Apr 20.

Department of Family Medicine, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang 43400, Malaysia.

Background: There is limited evidence on the association of anemia with chronic diseases and disabilities among older persons in Malaysia. We assessed the prevalence of anemia and its associated factors among community-dwelling older persons.

Methods: This was a cross-sectional study using data from the nationwide National Health and Morbidity Survey 2015 (NHMS 2015) on the health of older adults conducted by the Institute for Public Health, National Institutes of Health, Malaysia. Read More

ESC Heart Fail 2022 May 13. Epub 2022 May 13.

Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.

Aims: Multimorbidity is common among heart failure (HF) patients and may attenuate guideline-directed medical therapy (GDMT). Multimorbid patients are under-represented in clinical trials; therefore, the effect of multimorbidity clustering on the prognosis of HF patients remains unknown. We evaluated the prevalence of multimorbidity clusters among consecutively registered hospitalized HF patients and assessed whether GDMT attenuated outcomes. Read More

Front Pharmacol 2022 26;13:779694. Epub 2022 Apr 26.

Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.

Chronic kidney disease (CKD) is a global public health problem, and anemia is a common complication in CKD patients. Roxadustat (FG-4592) is an oral hypoxia-inducible factor (HIF) stabilizer. Roxadustat has been shown in studies to keep up with and increase hemoglobin better than placebo or erythropoietin. Read More

ACG Case Rep J 2022 May 9;9(5):e00773. Epub 2022 May 9.

Division of Gastroenterology, Department of Medicine, Stony Brook, NY.

We describe a case of an inverted Meckel's diverticulum presenting as an intraluminal subepithelial lesion on intraoperative enteroscopy. A 53-year-old woman presented with chronic iron deficiency anemia unresponsive to escalating iron supplementation. After equivocal upper and lower endoscopy and negative cross-sectional imaging, capsule endoscopy suggested a submucosal mass lesion in the proximal ileum. Read More

J Pediatr Pharmacol Ther 2022 9;27(4):384-389. Epub 2022 May 9.

Department of Pediatric Pharmacy (KH, AJ, AH, C.S. Mott Children's Hospital, Ann Arbor, MI.

Anemia is a predictor of morbidity and mortality in both pediatric and adult patients with heart failure. This risk is increased in patients who require ventricular assist device (VAD) placement. The most common mechanism suggested for why these patients develop anemia is chronic inflammation caused by the immune system reacting to the VAD components. Read More

Mod Rheumatol 2022 May 12. Epub 2022 May 12.

Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objectives: The concept of locomotive syndrome was proposed to highlight older adults who require nursing care services due to the malfunctioning of their locomotive organs. With the coming of a super-aging society, there is a growing need to understand relation between systemic chronic diseases and locomotive syndrome.

Methods: We analyzed the second-visit dataset of the Nagahama Study. Read More