30,559 results match your criteria Anemia Chronic


Transient aplastic crisis triggered by parvovirus B19 in a family with hereditary spherocytosis.

IDCases 2020 11;21:e00802. Epub 2020 May 11.

Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, EFS, Montpellier University Medical Centre, 34090, Montpellier, France.

Acute parvovirus B19 infection may lead to erythroblastopenia crisis in patients with underlying red blood cells disorders. We report herein an uncommon concomitant transient aplastic crisis in a mother and her daughter, both affected by hereditary spherocytosis. The diagnosis was confirmed by the detection of a very high parvovirus B19 DNA load in both the mother's and daughter's sera, associated with the presence of parvovirus B19 specific immunoglobulin-M antibodies. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242858PMC

Iron in infection and immunity.

Mol Aspects Med 2020 May 24:100864. Epub 2020 May 24.

Department of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of Innsbruck, Austria; Christian Doppler Laboratory for Iron Metabolism and Anemia Research, Medical University of Innsbruck, Austria. Electronic address:

Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both invading pathogens and mammalian cells including those of the immune system require iron to sustain their function, metabolism and proliferation. On the one hand, microbial iron uptake is linked to the virulence of most human pathogens. Read More

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http://dx.doi.org/10.1016/j.mam.2020.100864DOI Listing

Clinical manifestations and associated disorders in children with celiac disease in southern Iran.

BMC Pediatr 2020 May 27;20(1):256. Epub 2020 May 27.

Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, P.O. Box: 71345-1744, Shiraz, Iran.

Background: Celiac disease (CD) is an immune mediated inflammatory enteropathy, triggered by gluten exposure in HLA-DQ2 and/or -DQ8 genetics. The presentation of celiac disease in children is changing, with increase in non-classical symptoms. We aim to evaluate the clinical presentations of celiac disease amongst children, diagnosed with CD. Read More

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http://dx.doi.org/10.1186/s12887-020-02162-1DOI Listing

Anaemia, iron status, and gender predict the outcome in patients with chronic heart failure.

ESC Heart Fail 2020 May 27. Epub 2020 May 27.

Department of Internal Medicine II, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria.

Aims: Anaemia and iron deficiency (ID) are frequently found in patients with chronic heart failure (CHF) and associated with adverse outcome. However, it is unclear whether absolute [transferrin saturation (TSAT) <20%, ferritin <100 μg/L] or inflammation-driven functional ID (TSAT <20%, ferritin >100 μg/L) with and without anaemia had similar or different consequences for such patients.

Methods And Results: Within this retrospective cohort study, 2223 patients (1601 men and 622 women) with CHF, referred to our department, between 2000 and 2018, were followed for a median time of 84 months. Read More

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http://dx.doi.org/10.1002/ehf2.12755DOI Listing

Cytopenia among CML Patients on Imatinib in Kenya: Types, Grades, and Time Course.

Adv Hematol 2020 12;2020:7696204. Epub 2020 May 12.

Department of Clinical Medicine and Therapeutics, University of Nairobi, Nairobi, Kenya.

Background: Imatinib mesylate is the gold standard for the treatment of all phases of Philadelphia-positive chronic myeloid leukemia. Patients on imatinib treatment may develop cytopenia due to drug toxicity. This study aimed to determine the types, grades, and time course of cytopenia in CML patients on imatinib at a Nairobi hospital. Read More

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http://dx.doi.org/10.1155/2020/7696204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240645PMC

Simultaneous management of disordered phosphate and iron homeostasis to correct fibroblast growth factor 23 and associated outcomes in chronic kidney disease.

Curr Opin Nephrol Hypertens 2020 Jul;29(4):359-366

Division of Nephrology and Hypertension, Department of Medicine, and Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Purpose Of Review: Hyperphosphatemia, iron deficiency, and anemia are powerful stimuli of fibroblast growth factor 23 (FGF23) production and are highly prevalent complications of chronic kidney disease (CKD). In this manuscript, we put in perspective the newest insights on FGF23 regulation by iron and phosphate and their effects on CKD progression and associated outcomes. We especially focus on new studies aiming to reduce FGF23 levels, and we present new data that suggest major benefits of combined corrections of iron, phosphate, and FGF23 in CKD. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000614DOI Listing

Hypoxia-inducible factor prolyl hydroxylase inhibitor in the treatment of anemia in chronic kidney disease.

Curr Opin Nephrol Hypertens 2020 Jul;29(4):414-422

Division of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Purpose Of Review: Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are orally active small molecules and are launched as novel therapeutic agents for anemia in chronic kidney disease (CKD). In contrast to conventional exogenous erythropoietin (EPO) administration, HIF-PHIs stimulate endogenous EPO production and improve iron metabolism via stabilization of hypoxia-inducible factor (HIF). This review summarizes the mechanism of action, the results of clinical trials, and future perspectives of HIF-PHIs. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000617DOI Listing

A biomathematical model of human erythropoiesis and iron metabolism.

Sci Rep 2020 May 25;10(1):8602. Epub 2020 May 25.

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.

Anaemia therapy or perisurgical support of erythropoiesis often require both, EPO and iron medication. However, excessive iron medication can result in iron overload and it is challenging to control haemoglobin levels in a desired range. To support this task, we develop a biomathematical model to simulate EPO- and iron medication in humans. Read More

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http://dx.doi.org/10.1038/s41598-020-65313-5DOI Listing

Bullous pemphigoid associated chronic atrophic gastritis.

Dermatol Ther 2020 May 24:e13671. Epub 2020 May 24.

Department of Dermatology, Allergology and Venereology, Helsinki University Hospital.

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http://dx.doi.org/10.1111/dth.13671DOI Listing

Association between maternal HIV infection and birthweight in a tertiary hospital in southern Ethiopia: retrospective cohort study.

Ital J Pediatr 2020 May 24;46(1):70. Epub 2020 May 24.

School of Public Health, Addis Ababa University, Addis ababa, Ethiopia.

Background: Human Immunodeficiency Virus (HIV) infection and low birth weight (LBW) continue to be significant public health concerns in many low-income countries including Ethiopia. Yet the effect of maternal HIV infection on birth weight has not been thoroughly explored and the existing studies reported opposing findings. We examined the association between maternal HIV infection and LBW in a tertiary hospital in Southern Ethiopia. Read More

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http://dx.doi.org/10.1186/s13052-020-00834-3DOI Listing

SC411 treatment can enhance survival in a mouse model of sickle cell disease.

Prostaglandins Leukot Essent Fatty Acids 2020 May 3;158:102110. Epub 2020 May 3.

Department of Neurology, Louisiana State University Health Sciences Center, 1501 Kings Hwy Shreveport, LA, USA; Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA. Electronic address:

Sickle cell disease (SCD) is one of the most common inherited blood disorder among African Americans affecting 70,000-100,000 individuals in the United States. It is characterized by abnormal hemoglobin (HbS) which develops into severe hemolytic anemia and vaso-occlusive crisis. Therefore, patients with SCD suffer from a chronic state of inflammation, which is responsible for multiple organ damage, ischemic attacks, and premature death. Read More

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http://dx.doi.org/10.1016/j.plefa.2020.102110DOI Listing

A Case of Copper Deficiency Myeloneuropathy Precipitated by Zinc Ingestion and Bariatric Surgery.

S D Med 2020 Apr;73(4):178-180

Regional Health Neurology and Rehabilitation, Rapid City, South Dakota.

In this report, we present a case of acquired copper deficiency which initially presented as progressive pain and numbness in the patient's lower extremities. The acquired copper deficiency is attributed to a previous bariatric surgery exacerbated by zinc toxicity. A 42-year-old female with a past medical history of type 2 diabetes mellitus, anemia, hypertension, bipolar disorder, attention deficit disorder, pulmonary embolus, fibromyalgia, migraine headaches, and chronic pain as well as a remote past surgical history of gastric bypass procedure presented with progressive pain and numbness in her lower extremities. Read More

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β2-Microglobulin, Neutrophil Gelatinase-Associated Lipocalin, and Endocan Values in Evaluating Renal Functions in Patients with β-Thalassemia Major.

Hemoglobin 2020 May 22:1-6. Epub 2020 May 22.

Department of Biochemistry, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.

Chronic anemia, transfusion-associated iron deposition, and chelating agents lead to renal impairment in β-thalassemia (β-thal) patients. The present study aimed to determine the most reliable and practical method in assessing and predicting renal injury in β-thal major (β-TM) patients. Therefore, we assessed the predictive values of urine β2-microglobulin (β2-MG) and neutrophil gelatinase-associated lipocalin (NGAL) levels, their ratios to urine creatinine, and serum endocan level. Read More

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http://dx.doi.org/10.1080/03630269.2020.1766486DOI Listing

Mirror aneurysms of extracranial internal carotid arteries in a patient with beta-thalassemia major.

Acta Neurol Belg 2020 May 21. Epub 2020 May 21.

Department of Biochemistry, Erzurum Training and Research Hospital, Erzurum, Turkey.

Beta-thalassemia major is a chronic disorder characterised by severe anemia. This patient with beta-thalassemia major is the first magnetic resonance (MR) angiographic case for symmetric mirror aneurysms of the extracranial internal carotid arteries. For diagnosis of vascular complications requires angiographic procedures such as catheter angiography, computed tomography angiography, MR angiography, or Doppler ultrasonography. Read More

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http://dx.doi.org/10.1007/s13760-020-01379-2DOI Listing

2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring HbA production and chain rebalance.

Haematologica 2020 May 21. Epub 2020 May 21.

Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, USA;

β-thalassemia is a disorder caused by altered hemoglobin protein synthesis and affects individuals worldwide. Severe forms of the disease, left untreated, can result in death before the age of 3 years (1). The standard of care consists of chronic and costly palliative treatment by blood transfusion combined with iron chelation. Read More

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http://dx.doi.org/10.3324/haematol.2019.226852DOI Listing

Use of intravenous iron in patients with iron deficiency and chronic heart failure: Real-world evidence.

Eur J Intern Med 2020 May 19. Epub 2020 May 19.

Cardiovascular Diseases Research Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Community Heart Failure Program, Department of Cardiology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

Introduction And Objectives: Treatment with intravenous iron in patients with heart failure (HF) and iron deficiency (ID) improves symptoms, however its impact on survival and safety is unknown. We aimed to evaluate the management of ID and anemia with intravenous iron in patients with HF and long-term safety of intravenous iron.

Methods: We evaluated anemia and ID in patients with chronic HF at 3 university hospitals. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.04.031DOI Listing

Oral Iron for IBD Patients: Lessons Learned at Time of COVID-19 Pandemic.

J Clin Med 2020 May 19;9(5). Epub 2020 May 19.

Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Milan, Italy.

Anemia is a frequent manifestation in patients with chronic inflammatory bowel disease (IBD) and requires tight monitoring and adequate supplementary therapy. Intravenous iron is the first-line treatment in subjects with moderate-severe anemia, active disease, or oral iron intolerance. On the other hand, oral iron is recommended in patients with mild anemia and inactive disease. Read More

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http://dx.doi.org/10.3390/jcm9051536DOI Listing

A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the Anemia of Chronic Disease.

Blood 2020 May 21. Epub 2020 May 21.

Innsbruck Medical University, Innsbruck, Austria.

Recombinant erythropoietin (EPO) and iron substitution are a standard of care for treatment of anemias associated with chronic inflammation including anemia of chronic kidney disease. A black box warning for EPO therapy and concerns about negative side effects related to high-dose iron supplementation as well as the significant proportion of patients becoming EPO resistant over time, explains the medical need to define novel strategies to ameliorate anemia of chronic disease (ACD). As hepcidin is central to the iron-restrictive phenotype in ACD, therapeutic approaches targeting hepcidin were recently developed. Read More

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http://dx.doi.org/10.1182/blood.2019004653DOI Listing

Impact of anemia on the outcomes of chronic phase chronic myeloid leukemia in TKI era.

Hematology 2020 Dec;25(1):181-185

Department of Hematology, The Huaian Clinical College of Xuzhou Medical University, Huai'an, People's Republic of China.

It is common of chronic phase chronic myeloid leukemia (CML-CP) patients coexisting anemia at diagnosis, but the role of anemia on the prognosis is not clear. This study aims to explore impact of anemia on outcomes of CML-CP patients in TKI era. In the retrospective study, 258 newly diagnosed CML patients treated with TKIs were enrolled. Read More

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http://dx.doi.org/10.1080/16078454.2020.1765563DOI Listing
December 2020

Takotsubo syndrome and cancer, clinical and prognostic implications, insights of RETAKO.

Med Clin (Barc) 2020 May 16. Epub 2020 May 16.

Servicio de Cardiología, Hospital Joan XXIII, Tarragona, España.

Background And Objectives: A relationship between neoplasms and Takotsubo syndrome (TS) has been postulated. Our goal was to determine its prevalence in patients with TS, compare the clinical profile of TS with or without cancer and study its long-term evolution.

Materials And Methods: The oncological situation of patients included in the National Registry on TAKOtsubo syndrome (RETAKO), admitted between 2002 and 2019, provided by 38 hospitals throughout the country is analysed. Read More

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http://dx.doi.org/10.1016/j.medcli.2020.01.033DOI Listing

Gastrointestinal manifestations in Satoyoshi syndrome: a systematic review.

Orphanet J Rare Dis 2020 May 19;15(1):115. Epub 2020 May 19.

Department of Internal Medicine, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.

Background: Satoyoshi syndrome (SS) [OMIM 600705; ORFHA 3130] is a multisystemic disease with a probable autoimmune basis, whose main symptoms are muscle spasms, alopecia, diarrhea and skeletal alterations. Chronic diarrhea may be severe and result in malnutrition, anemia, growth retardation, cachexia, disability and even death. However, to date, no review of the digestive symptoms has been carried out. Read More

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http://dx.doi.org/10.1186/s13023-020-01395-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236136PMC

CTLA4Ig In An Extended Schedule Along With Sirolimus Improves Outcome With A Distinct Pattern of Immune Reconstitution Following Post-Transplantation Cyclophosphamide Based Haploidentical Transplantation For Hemoglobinopathies.

Biol Blood Marrow Transplant 2020 May 16. Epub 2020 May 16.

Cellular Therapy and Immunology, Manashi Chakrabarti Foundation, Kolkata, India; Department Of Blood and Marrow Transplantation, Dharamshila Narayana Superspeciality Hospital and Research Centre, New Delhi.

The major hindrances to the success of a haploidentical HCT for hemoglobinopathies are graft failure, early post-transplant hemophagocytic syndrome (PTHPS) and graft-versus-host disease (GVHD). Following the successful incorporation of CTLA4Ig (Abatacept) in post-transplantation cyclophosphamide (PTCy) based haploidentical transplantation, we piloted this approach in 10 patients (age 3-19 years), with thalassemia major (TM, n=5) and sickle cell disease (SCD, n=5). Pretransplant immunosuppressive therapy (pTIST) was administered for 10 weeks. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.05.005DOI Listing

Mu opioid receptor knockout mouse: Phenotypes with implications on restless legs syndrome.

J Neurosci Res 2020 May 19. Epub 2020 May 19.

Norman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.

Restless legs syndrome (RLS) is characterized by an irresistible need to move the legs while sitting or lying at night with insomnia as a frequent consequence. Human RLS has been associated with abnormalities in the endogenous opioid system, the dopaminergic system, the iron regulatory system, anemia, and inflammatory and auto-immune disorders. Our previous work indicates that mice lacking all three subtypes of opioid receptors have a phenotype similar to that of human RLS. Read More

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http://dx.doi.org/10.1002/jnr.24637DOI Listing

Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?

Sci Rep 2020 May 18;10(1):8161. Epub 2020 May 18.

Department of Chemistry and Biochemistry and Department of Pharmacology, University of California at San Diego, La Jolla, CA, 92093-0601, USA.

Dietary odd-chain saturated fatty acids (OCFAs) are present in trace levels in dairy fat and some fish and plants. Higher circulating concentrations of OCFAs, pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0), are associated with lower risks of cardiometabolic diseases, and higher dietary intake of OCFAs is associated with lower mortality. Population-wide circulating OCFA levels, however, have been declining over recent years. Read More

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http://dx.doi.org/10.1038/s41598-020-64960-yDOI Listing

Acute decompensated heart failure in a North Indian community hospital: Demographics, clinical characteristics, comorbidities and adherence to therapy.

Indian Heart J 2020 Jan - Feb;72(1):27-31. Epub 2020 Mar 24.

Department of Cardiac Sciences, Fortis Hospital, Shalimar Bagh, Delhi, 88, India. Electronic address:

Background: Acute decompensated heart failure (ADHF) is a growing public health problem in the community. Limited and often contradictory data are available from small studies published from India. Objective of this study was to report clinical characteristics, outcome, and discharge treatment strategies of these patients from a single community hospital. Read More

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http://dx.doi.org/10.1016/j.ihj.2020.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231861PMC

Managing breakthrough pain for advanced malignancy in elderly patients: A real challenge.

J Opioid Manag 2020 May/Jun;16(3):219-222

Additional Professor, Department of Onco-Anaesthesia and Palliative medicine, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India.

Pain management in advanced cancer patients using opioids like morphine is challenging due to presence of predisposing factors like renal insufficiency, hepatic insufficiency, hypoproteinemia, hypoalbuminemia, and anemia that can easily precipitate inadvertent toxic effects. We report a case morphine toxicity in an elderly patient of lung cancer with concomitant presence of chronic obstructive pulmonary disease (COPD) and recent onset renal impairment. Opioid analgesic overdose is a lethal but at the same time, a preventable and treatable condition. Read More

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http://dx.doi.org/10.5055/jom.2020.0571DOI Listing

The changing landscape of iron deficiency.

Mol Aspects Med 2020 May 14:100861. Epub 2020 May 14.

Department of Medicine, Section of Internal Medicine, EuroBloodNet Center, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Italy.

Iron deficiency (ID) with or without anemia is common worldwide. ID is a broad definition encompassing decreased total body iron (absolute deficiency) as well as reduced iron supply to erythropoietic and/or other organs with preserved stores (functional iron deficiency, FID), as it occurs in inflammation. Increased iron needs unbalanced by iron supply, low iron intake, reduced absorption and chronic blood loss, often in combination, are the main causes of absolute ID, easily diagnosed by low ferritin levels. Read More

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http://dx.doi.org/10.1016/j.mam.2020.100861DOI Listing

The Effect of Frailty on Long Term Outcomes in Vascular Surgical Patients.

Eur J Vasc Endovasc Surg 2020 May 14. Epub 2020 May 14.

Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. Electronic address:

Objective: Frailty is a multidimensional vulnerability due to age associated decline. The impact of frailty on long term outcomes was assessed in a cohort of vascular surgical patients.

Methods: Patients aged over 65 years with a length of stay greater than two days admitted to a tertiary vascular unit over a single calendar year were included. Read More

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http://dx.doi.org/10.1016/j.ejvs.2020.04.009DOI Listing

Endoscopic submucosal dissection of a proximal esophageal hemangioma accompanied with gastrointestinal bleeding.

Dig Endosc 2020 May 16. Epub 2020 May 16.

Department of Gastroenterology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.

A 57-year-old female with a history of chronic gastritis presented with a 3-day history of melena and asthenia. Physical examination and laboratory data were normal besides a mild tachycardia and microcytic hypochromic anemia. Gastroscopy showed a 20-mm diameter, bluish submucosal mass at the esophageal entrance, swinging to the hypopharynx once vomit occurred (Fig. Read More

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http://dx.doi.org/10.1111/den.13721DOI Listing

New Insights of Human Parvovirus B19 in Modulating Erythroid Progenitor Cell Differentiation.

Viral Immunol 2020 May 15. Epub 2020 May 15.

Pediatrics Department, Children Digital and Health Data Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.

Human parvovirus B19 (B19), a human pathogen of the erythroparvovirus genus, is responsible for a variety of diseases. B19 cause less symptoms in healthy individuals, also cause acute and chronic anemia in immunodeficiency patients. Transient aplastic crisis and pure red cell aplasia are two kinds of anemic hemogram, respectively, in acute and chronic B19 infection phase, especially occurring in patients with a shortened red cell survival or with immunodeficiency. Read More

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http://dx.doi.org/10.1089/vim.2020.0013DOI Listing

Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network Highlighted by TCD4+CD69+ Lymphocytes, IL-17/MIP-1, IL-12/VEGF, and IL-10/IP-10 Axis.

J Immunol Res 2020 8;2020:4585704. Epub 2020 Jan 8.

Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas (UFAM), 69077-000 Manaus, AM, Brazil.

Background: Sickle cell anemia (SCA) is associated with a chronic proinflammatory state characterized by elevated leukocyte count, mortality from severe recurrent infections, and subsequent vasoocclusive complications with leukocyte adhesion to the endothelium and increased plasma levels of inflammatory cytokines. The immune system has a close connection with morbidity in SCA, but further studies are needed to uncover the involvement of innate and adaptive immunities in modulating the SCA physiopathology. We performed measurements of the frequency of innate and adaptive immunity cells, cytokines, chemokines, and growth factors and immunophenotyping of Toll-like receptor and adhesion molecule expression in the blood of SCA patients and healthy donors to evaluate the different profiles of these biomarkers, the relationship among them, and their correlation to laboratory records and death risk. Read More

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http://dx.doi.org/10.1155/2020/4585704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199620PMC
January 2020

Cameron Ulcers: Rare Case of Overt Upper Gastrointestinal Bleed in a Patient with Alcohol Use Disorder.

Cureus 2020 Apr 12;12(4):e7644. Epub 2020 Apr 12.

Gastroenterology, BronxCare Health System, Bronx, USA.

Cameron lesion is an uncommon cause of overt upper gastrointestinal bleed (GI bleed). Though hiatal hernia is a well-known entity, Cameron lesions that may occur in them are usually missed during upper endoscopy. Patient with Cameron lesions usually presents as chronic iron deficiency anemia, rarely as acute GI bleed. Read More

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http://dx.doi.org/10.7759/cureus.7644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217238PMC

Chitosan-Based Nanoparticles for Intracellular Delivery of ISAV Fusion Protein cDNA into Melanoma Cells: A Path to Develop Oncolytic Anticancer Therapies.

Mediators Inflamm 2020 29;2020:8680692. Epub 2020 Apr 29.

Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile (USACH), Alameda, 3363 Santiago, Chile.

Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation and immunogenic cell death of eukaryotic cells. We have previously demonstrated that tumor cell bodies generated from cells expressing the fusogenic protein of the infectious salmon anemia virus (ISAV-F) enhance crosspriming and display prophylactic antitumor activity against melanoma tumors. Read More

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http://dx.doi.org/10.1155/2020/8680692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206890PMC
April 2020
3.236 Impact Factor

IgA nephropathy associated with thalassemia: a case report.

BMC Nephrol 2020 May 14;21(1):182. Epub 2020 May 14.

The Department of Nephrology (Key laboratory of management of kidney disease in Zhejiang province), Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, P. R. China.

Background: Thalassemia is a group of hereditary diseases characterized by a common recessive monogenic hematological disorder, presenting a significant public health concern in the developing countries. Recent studies have identified the renal effects of thalassemia syndrome. Chronic hypoxia, long-term anemia, iron overload, and iron chelators are the major causes of renal tubular dysfunction and glomerular filtration abnormalities, while glomerulonephritis is not considered a major cause of abnormal urinalysis. Read More

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http://dx.doi.org/10.1186/s12882-020-01844-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227039PMC

Morphogen signaling by Wnt/β-catenin pathway and microenvironmental alteration in the bone marrow of agricultural pesticide exposure-induced experimental aplastic anemia.

J Biochem Mol Toxicol 2020 May 14:e22523. Epub 2020 May 14.

Stem Cell Research and Application Unit, Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.

The etiologic link between pesticide toxicity and aplastic anemia in agricultural and agro-industrial setting has been frequently reported in epidemiological studies conducted worldwide. Chronic pesticide toxicity causes long-term bone marrow injury and perturbs the normal hematopoietic physiology, including survival of hematopoietic progenitor cells and bone marrow's blood cell forming ability. The purpose of this study is to understand the mechanism of pesticide toxicity-mediated bone marrow aplasia by studying Wnt/β-catenin signaling pathway and microenvironmental stromal components. Read More

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http://dx.doi.org/10.1002/jbt.22523DOI Listing

[Use of iron in nephrology: Results of a French practical survey].

Nephrol Ther 2020 May 11. Epub 2020 May 11.

Centre NephroCare Tassin Charcot, 69110 Sainte-Foy-lès-Lyon, France.

The French-speaking Society of Nephrology, Dialysis and Transplantation conducted, in 2018, a survey among French nephrologists into their iron prescribing habits for patients with chronic kidney disease stages 3 to 5 before dialysis. The results show that 73% of nephrologists use intravenous iron before dialysis stage. When a patient has gastrointestinal symptoms under oral iron therapy, only 48% of nephrologists use intravenous route. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.10.002DOI Listing

Mortality of children aged 5-15 years in a tertiary care center in Yaoundé, Cameroon.

Arch Pediatr 2020 May 11. Epub 2020 May 11.

Faculty of medicine and biomedical sciences of the University of Yaoundé I, Yaoundé, Cameroon; Mother and Child Centre of the Chantal Biya Foundation of Yaoundé, Yaoundé, Cameroon.

Introduction: Although sub-Saharan Africa accounts for only 21% of the global population of children and adolescents aged 5-15 years, 55% of deaths among children in this age group occur in this region. This seems to be related to infectious diseases. We hypothesized that besides infectious diseases, in our context, a chronic underlying condition increases mortality. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.05.006DOI Listing

Diagnosis Patterns of CKD and Anemia in the Japanese Population.

Kidney Int Rep 2020 May 10;5(5):694-705. Epub 2020 Apr 10.

Medical Affairs, Astellas Pharma Inc., Tokyo, Japan.

Introduction: Although early intervention for chronic kidney disease (CKD) and renal anemia are desirable, these conditions are often asymptomatic during their early stages and may be underdiagnosed.

Methods: We retrospectively analyzed Japanese administrative claims data for general and hospital populations. The data period for the general and hospital data ranged from January 2011 to December 2016 and from April 2008 to July 2017, respectively. Read More

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http://dx.doi.org/10.1016/j.ekir.2020.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210702PMC

The CRAS-EAHFE study: Characteristics and prognosis of acute heart failure episodes with cardiorenal-anaemia syndrome at the emergency department.

Eur Heart J Acute Cardiovasc Care 2020 May 14:2048872620921602. Epub 2020 May 14.

Emergency Department, Hospital Clínic, University of Barcelona, Spain.

Background: The coexistence of other comorbidities confers poor outcomes in patients with acute heart failure. Our aim was to determine the characteristics of patients with acute heart failure and cardiorenal anaemia syndrome and the relationship between renal dysfunction and anaemia, alone or combined as cardiorenal anaemia syndrome, on short-term outcomes.

Methods: We analysed the Epidemiology of Acute Heart Failure in Emergency Departments registry (cohort of patients with acute heart failure in Spanish emergency departments). Read More

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http://dx.doi.org/10.1177/2048872620921602DOI Listing

Polycythemia and Anemia in Hereditary Hemochromatosis.

Cureus 2020 Apr 9;12(4):e7607. Epub 2020 Apr 9.

Gastroenterology and Hepatology, West Virginia University School of Medicine, Morgantown, USA.

Introduction Hereditary hemochromatosis is a syndrome of dysregulated iron homeostasis resulting in the excessive deposition of iron. Hemochromatosis causes pulmonary, pancreatic, and hepatic dysfunction, all of which are risk factors for anemia in the general population. Conversely, iron overload states are thought to predispose to polycythemia. Read More

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http://dx.doi.org/10.7759/cureus.7607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213665PMC

Role of Ribavirin in the Era of Direct-Acting Antiviral Therapies of Chronic Hepatitis C.

Expert Rev Anti Infect Ther 2020 May 13:1-6. Epub 2020 May 13.

Department of Hepatology, National Liver Institute, Menoufia University, Shebin El-kom, Egypt.

: The efficacy of adding ribavirin (RBV) to direct antivirals (DAAs) in HCV treatment is still debatable, with allegations of insecure profiles.: To evaluate safety and efficacy of RBV in the era of DAAs in chronic HCV Egyptian patients.: In this cohort retrospective study, data of 847 HCV patients treated with different regimens of DAAs with or without RBV were recruited between June 2017 and September 2018. Read More

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http://dx.doi.org/10.1080/14787210.2020.1758557DOI Listing

Spinal Cord Ischemia Because of Microvascular Thrombosis in a Patient with Necrotizing Pancreatitis. Case Report and Literature Review.

Am J Case Rep 2020 May 12;21:e923273. Epub 2020 May 12.

Department of Clinical Radiology, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND Central nervous system ischemia in acute pancreatitis is rare with only a handful of cases reported in the literature. We report a case of spinal cord ischemia due to microvascular thrombosis complicating acute on chronic pancreatitis. CASE REPORT A 37-year-old male was transferred to a university hospital intensive care unit with a diagnosis of acute onset chronic pancreatitis, paraplegia, and multi-organ failure. Read More

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http://dx.doi.org/10.12659/AJCR.923273DOI Listing

Treatment of relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma with the BTK inhibitor zanubrutinib: phase 2, single-arm, multicenter study.

J Hematol Oncol 2020 May 11;13(1):48. Epub 2020 May 11.

Department of Hematology, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.

Background: Bruton tyrosine kinase (BTK) inhibitors have demonstrated a high degree of efficacy in the treatment of B cell malignancies characterized by constitutive B cell receptor activation, including chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).

Methods: The efficacy and safety of zanubrutinib, an investigational highly selective BTK inhibitor, was evaluated in this single-arm, phase 2 study of Chinese patients with relapsed/refractory CLL/SLL. The primary endpoint was overall response rate as assessed by an independent review committee. Read More

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http://dx.doi.org/10.1186/s13045-020-00884-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216400PMC

Hematopoietic Cell Transplantation with Cryopreserved Grafts for Severe Aplastic Anemia.

Biol Blood Marrow Transplant 2020 May 8. Epub 2020 May 8.

Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; Division of Hematology-Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.

With the COVID-19 pandemic and the ensuing barriers to the collection and transport of donor cells, it is often necessary to collect and cryopreserve grafts before initiation of transplantation conditioning. The effect on transplantation outcomes in nonmalignant disease is unknown. This analysis examined the effect of cryopreservation of related and unrelated donor grafts for transplantation for severe aplastic anemia in the United States during 2013 to 2019. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206419PMC

Glucose 6 Phosphate Dehydrogenase Deficiency: Description of a novel and de novo variant associated with chronic nonspherocytic hemolytic anemia.

Clin Biochem 2020 May 6. Epub 2020 May 6.

Hospital de Pediatria Dr J P GarraHan, Combate de los Pozos 1881, C1245AAM Ciudad Autonoma de Buenos Air, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2020.04.007DOI Listing

Research progress in relation of infection with pregnancy-related diseases and adverse pregnancy outcomes.

Authors:
Bai Zhou Fen Wang

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Mar;45(3):338-344

Depatment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013

() is a Gram-negative microaerobic bacterium, which is parasitic on gastric mucosa and is associated with the pathogenesis of chronic gastritis, gastric ulcer, gastric cancer and other gastric diseases. Meanwhile, the infection is related with pregnancy-related diseases, pregnancy outcomes, and the health status of offspring, such as infertility, premature delivery, abortion, infection of newborn and neural tube defects. infection is also related to hyperemesis of pregnancy, preeclampsia, gestational diabetes mellitus, iron deficiency anemia, idiopathic thrombocytopenic purpura. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.190032DOI Listing

Physical illnesses associated with childhood homelessness: a literature review.

Ir J Med Sci 2020 May 8. Epub 2020 May 8.

Graduate Entry Medical School (GEMS), University of Limerick, Limerick, Ireland.

Background: Childhood homelessness is a growing concern in Ireland [1] creating a paediatric subpopulation at increased risk of physical illnesses, many with life-long consequences [2].

Aim: Our aim was to identify and categorize the physical morbidities prevalent in homeless children.

Methods: A review of the English-language literature on physical morbidities affecting homeless children (defined as ≤ 18 years of age) published from 1999 to 2019 was conducted. Read More

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http://dx.doi.org/10.1007/s11845-020-02233-3DOI Listing

Nephrectomy Does not Exacerbate Cancellous Bone loss in Thalassemic Mice.

Sci Rep 2020 May 8;10(1):7786. Epub 2020 May 8.

Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

Patients with β-thalassemia have an increased risk of developing chronic kidney disease which is associated with osteoporosis and periodontitis. The purpose of this study was to evaluate mandibular and femoral bone change in heterozygous β-globin knockout (BKO) mice following 5/6 nephrectomy (Nx). Female and male BKO mouse blood smears demonstrated microcytic hypochromic anemia. Read More

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http://dx.doi.org/10.1038/s41598-020-64681-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210954PMC

Development of the InCharge Health Mobile App to Improve Adherence to Hydroxyurea in Patients With Sickle Cell Disease: User-Centered Design Approach.

JMIR Mhealth Uhealth 2020 May 8;8(5):e14884. Epub 2020 May 8.

Department of Hematology, St Jude Children's Research Hospital, Memphis, TN, United States.

Background: Sickle cell disease (SCD) is an inherited blood disorder causing acute complications and chronic progressive end organ damage. SCD is associated with significant morbidity, early mortality, impaired health-related quality of life, and increased acute health care utilization. Hydroxyurea is a US Food and Drug Administration-approved medication that reduces disease complications, acute health care utilization, and costs. Read More

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http://dx.doi.org/10.2196/14884DOI Listing

The Role of Feedback Control Design in Developing Anemia Management Protocols.

Ann Biomed Eng 2020 May 7. Epub 2020 May 7.

Mathematics and Statistics Department, University of Massachusetts, Amherst, MA, 01003, USA.

The optimal use of erythropoiesis stimulating agents to treat anemia of end-stage renal disease remains difficult due to reported associations with adverse events. A patient's hemoglobin response to these agents cannot be accurately described using population-level models due to many individual factors including chronic inflammation, red blood cell lifespan, and acute blood loss. As a consequence, it is generally understood that current one-size-fits-all anemia management protocols result in suboptimal outcomes. Read More

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http://dx.doi.org/10.1007/s10439-020-02520-1DOI Listing