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Sci Rep 2022 Jun 24;12(1):10741. Epub 2022 Jun 24.

International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

Data are limited on the prevalence and outcome of anemia and its risk on mortality among children under five years of age hospitalized for pneumonia/severe pneumonia. Thus, we conducted a secondary analysis of data extracted from Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh to address the evidence gap. Among 3468 children fulfilling the study criteria,1712 (49. Read More

West Afr J Med 2022 Jun;39(6):568-572

Department of Internal Medicine, Lagos University Teaching Hospital, Idi-Araba, Lagos State, Nigeria.

Background: Intestinal helminthiases are public health problems of children in developing countries of the world and account for significant morbidity as it results in stunted growth, intestinal obstruction, anaemia, cognitive impairment, acute pancreatitis, acute cholecystitis and rectal prolapse. This study assessed intestinal helminths, infection intensity and symptoms in primary school children in Ile-Ife.

Methods: It was a cross sectional study. Read More

Gynecol Minim Invasive Ther 2022 Apr-Jun;11(2):127-130. Epub 2022 May 4.

Department of Gynecologic Oncology, Kawasaki Medical School, Okayama, Japan.

We presented a case of uncontrolled genital bleeding caused by subserosal fibroid and treated by robotic-assisted hysterectomy during the coronavirus disease 2019 (COVID-19) pandemic. A 49-year-old woman had severe anemia with hypermenorrhea due to submucosal fibroid. Hysterectomy was deemed necessary to control genital bleeding. Read More

J Clin Med 2022 Jun 20;11(12). Epub 2022 Jun 20.

Bank of Blood and Tissue of Navarra, Government of Navarra, 31008 Pamplona, Spain.

Severe traumatic injury is one of the main global health issues which annually causes more than 5.8 million worldwide deaths. Uncontrolled haemorrhage is the main avoidable cause of death among severely injured individuals. Read More

Children (Basel) 2022 Jun 15;9(6). Epub 2022 Jun 15.

Department of Pediatrics, King Fahad Hospital of the University, Al-Khobar 31952, Saudi Arabia.

Acute chest syndrome (ACS) is a common cause of death in sickle cell disease (SCD) patients. Multiple studies investigated the risk factors of developing ACS; however, predictors of recurrent ACS episodes have not been thoroughly investigated. We aim to examine the clinical and laboratory predictors of recurrent ACS in pediatric patients with SCD. Read More

Animals (Basel) 2022 Jun 20;12(12). Epub 2022 Jun 20.

California Animal Health and Food Safety, University of California-Davis, San Bernardino, CA 92408, USA.

Yellow lamb disease is an infrequent disease in sheep for which there is scant literature, and that has been reported in the US, Australia, New Zealand, South Africa and Europe, although anecdotal evidence indicates that it may have also been diagnosed in South America. The disease is produced by some strains of type A that produce unusually high levels of alpha- toxin. Because type A is ubiquitous and is found in the intestine of most clinically healthy sheep, diagnosis of yellow lamb disease is challenging and requires quantitating the amount of this microorganism present in feces and/or intestinal content. Read More

Animals (Basel) 2022 Jun 8;12(12). Epub 2022 Jun 8.

Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, N-4325 Sandnes, Norway.

The liver fluke may cause severe infection in several mammalian species, including sheep and humans. Fasciolosis is a parasitic disease occurring worldwide in temperate climates and involves intermediate lymnaeid snails as vectors, in Europe the pond snail in particular. In the sheep industry, the disease is a serious welfare and health problem. Read More

Ann Hematol 2022 Jun 23. Epub 2022 Jun 23.

National Clinical Research Centre for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplant, Peking University People's Hospital, Peking University Institute of Hematology, No. 11 Xizhimen South Street, Xicheng District, 100044, Beijing, China.

Hepatitis-associated aplastic anemia (HAAA), a rare subtype of aplastic anemia (AA), is defined as bone marrow failure occurring after acute hepatitis. Severe HAAA requires immunosuppressive therapy (IST) or hematopoietic stem cell transplantation (HSCT) as lifesaving treatment. The outcomes of HAAA patients who underwent haploidentical hematopoietic stem cell transplantation (haplo-HSCT) have not been systematically evaluated. Read More

Metabolites 2022 Jun 14;12(6). Epub 2022 Jun 14.

Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Coronavirus disease 2019 (COVID-19) is frequently associated with iron dyshomeostasis. The latter is related to acute disease severity and COVID-19 convalescence. We herein describe iron dyshomeostasis at COVID-19 follow-up and its association with long-term pulmonary and symptomatic recovery. Read More

Global Spine J 2022 Jun 23:21925682221110819. Epub 2022 Jun 23.

Department of Orthopaedic Surgery, 3718Waikato Hospital, Hamilton, New Zealand.

Study Design: Retrospective cohort study.

Objectives: Development, validation, and decision curve analysis of a novel tool (NZSpine) for modelling risk of complications within 30 days of spine surgery.

Methods: Data was gathered retrospectively from medical records of patients who underwent spine surgery at a single tertiary centre between January 2019 and December 2020 (n = 488). Read More

Rev Med Chil 2021 Nov;149(11):1668-1672

Departamento de Nefrología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

The Shiga toxin associated (Stx) hemolytic uremic syndrome (HUS) is an important cause of acute renal failure (ARF) and the most common cause of thrombotic microangiopathy (TMA) in pediatrics. Primary atypical HUS (aHUS) is a rare disease due to a genetic defect in the alternative complement pathway. Both diseases may share clinical and laboratory elements, making differential diagnosis difficult, such as the presence of diarrhea in aHUS or complement alterations in HUS-Stx. Read More

Pediatr Transplant 2022 Jun 23:e14340. Epub 2022 Jun 23.

Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Background: Non-severe aplastic anemia is more likely to develop into severe aplastic anemia, and there is no widely accepted treatment plan at present. Hematopoietic stem cell transplantation might be a new therapeutic strategy.

Methods: Retrospectively analyzed 32 patients with non-severe aplastic anemia who underwent hematopoietic stem cell transplantation from September 2007 to September 2020, and the 5-year estimated overall survival rate and the incidence of graft-versus-host disease were analyzed to evaluate the efficacy and safety of hematopoietic stem cell transplantation in the treatment of pediatric non-severe aplastic anemia. Read More

Pan Afr Med J 2022 29;41:257. Epub 2022 Mar 29.

Service d'Hématologie Clinique, Centre Hospitalier Universitaire Mohammed VI Marrakech, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.

Malignant hypercalcaemia is a metabolic emergency. Its association with solid tumors is common, whereas it has been rarely described in patients with malignant hemopathies other than multiple myeloma and T-cell leukemias/T-cell lymphomas associated with lymphotropic virus type I (HTLV-I). We here report the case of a female patient with acute lymphoblastic leukemia revealed by malignant hypercalcaemia and pathological fracture of the humerus. Read More

Clin Case Rep 2022 Jun 13;10(6):e5962. Epub 2022 Jun 13.

Department of Internal Medicine, Hurley Medical Center Michigan State University Flint Michigan USA.

In the absence of typical features and risks for life-threatening chest pain including aortic dissection, the obligation and urgency for their evaluation remains unimpeachable, more so when patients present in stable conditions suggestive of benign etiology. Better do the painstaking, rather than be undone by the pain. Read More

Maedica (Bucur) 2022 Mar;17(1):80-87

Department of Nephrology, AIIMS, New Delhi, India.

This study aimed to investigate the incidence, clinical characteristics, and outcomes of acute kidney injury (AKI) during pregnancy in Indian population. A prospective observational study was conducted in pregnant patients admitted to Pt. B. Read More

Cureus 2022 May 18;14(5):e25096. Epub 2022 May 18.

Internal Medicine, BronxCare Health System, Bronx, USA.

Atypical hemolytic uremic syndrome (HUS) is a rare but severe form of thrombotic microangiopathies (TMAs) that affects both children and adults. The clinical presentation is usually nonspecific, including a broad spectrum of symptoms ranging from abdominal pain, confusion, diarrhea, fatigue, irritability, hypertension, and lethargy. We present a case of a 36-year-old woman with medical comorbidities of asthma and pulmonary embolism who presented to our hospital in the 36th week of her pregnancy for preterm premature rupture of the membranes. Read More

J Investig Med 2022 06;70(5):1316-1319

Department of Internal Medicine, The University of Texas Health Science Center at Houston, John P and Katherine G McGovern Medical School, Houston, Texas, USA.

Patients with sickle cell disease (SCD) experience a range of clinical symptoms, including acute and chronic pain, fatigue, and respiratory problems, as well as chronic organ complications that can lead to disability and accelerated mortality. Voxelotor is a first-in-class therapy that targets sickle hemoglobin polymerization, the root cause of SCD. It is approved by the US Food and Drug Administration for treatment of SCD in patients aged 4 years and older and in the European Union and United Arab Emirates for the treatment of SCD in patients aged 12 years and older. Read More

J Pediatr Hematol Oncol 2022 Jul 13;44(5):e905-e910. Epub 2021 Aug 13.

Hematology, University of Health Sciences Ankara Training and Research Hospital, Ankara, Turkey.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder resulting from excessive activation and nonmalignant proliferation of T-lymphocytes and macrophages. Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Reports pertaining to the association between HLH and HUS are rarely published; however, we report on a 4-year-old boy who was diagnosed with both conditions and treated successfully with high-dose steroid and intravenous immunoglobulin. Read More

Microbiol Spectr 2022 Jun 22:e0066022. Epub 2022 Jun 22.

Department of Microbiology, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway.

Shiga toxin-producing Escherichia coli (STEC) infection can cause mild to severe illness, such as nonbloody or bloody diarrhea, and the fatal hemolytic uremic syndrome (HUS). The molecular mechanism underlying the variable pathogenicity of STEC infection is not fully defined so far. Here, we performed a comparative genomics study on a large collection of clinical STEC strains collected from STEC-infected pediatric patients with and without HUS in Finland over a 16-year period, aiming to identify the bacterial genetic factors that can predict the risk to cause HUS and poor renal outcome. Read More

Ren Fail 2022 Dec;44(1):1061-1069

Department of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, P. R. China.

Objective: To explore the clinical characteristics, treatment protocol and prognosis of children with anti-complement factor H (CFH) autoantibody (Ab)-associated hemolytic uremic syndrome (HUS).

Methods: Clinical data of 8 patients with anti-CFH Ab-associated HUS who were admitted to Shandong Provincial Hospital from January 2011 to December 2020 were collected retrospectively.

Results: The age at disease onset ranged between 5. Read More

An Pediatr (Engl Ed) 2022 Jun 18. Epub 2022 Jun 18.

Servicio de Pediatría, Hospital Universitario Cruces, Osakidetza, Barakaldo, Bizkaia, Spain; Biocruces Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain. Electronic address:

Introduction: Sickle cell disease is an emerging anemia in Europe leading to high morbidity with severe acute complications requiring hospital admission and chronic consequences. The management of these patients is complex and needs interdisciplinary care. The objective is to analyze clinical characteristics and management of patients with sickle cell disease admitted for acute complications. Read More

Blood Adv 2022 Jun 21. Epub 2022 Jun 21.

Sylvester Comprehensive Cancer Center, University of Miami, Miami, Ohio, United States.

PANTHER was a global, randomized phase 3 trial of pevonedistat plus azacitidine (n = 227) vs azacitidine monotherapy (n = 227) in patients with newly diagnosed higher-risk myelodysplastic syndromes (MDS) (n = 324), higher-risk chronic myelomonocytic leukemia (n = 27), or acute myeloid leukemia (AML) with 20-30% blasts (n = 103). The primary endpoint was event-free survival (EFS). In the intent-to-treat (ITT) population median EFS was 17. Read More

Burns 2022 May 17. Epub 2022 May 17.

The Professor Stuart Pegg Adult Burns Centre, The Royal Brisbane and Women's Hospital, QLD, Australia.

Purpose: The iron status of burn patients is poorly understood, limited by difficulty interpreting conventional iron studies in the context of the acute phase response triggered by critical illness. The aim of this study was to evaluate the iron status of patients with burn anaemia using recent post-operative guidelines.

Methodology: This retrospective cohort study utilised data collected from records for adult patients admitted to the Royal Brisbane and Women's Hospital with burns to at least 15% TBSA. Read More

Hematology 2022 Dec;27(1):742-744

Montefiore Medical Center, Bronx, NY, USA.

People with sickle cell disease (SCD) are more vulnerable to hospitalization, pneumonia, and pain following COVID-19 infection. However, given the association between the inflammatory response and vaso-occlusive crises in SCD and a case report of vaso-occlusive crises following administration of the ChAdOx1 nCov-195-7/AstraZeneca vaccine, there is concern that the administration of COVID-19 vaccines in people with SCD might provoke a vaso-occlusive crisis. To address this critical gap in knowledge, we sought to examine acute care usage for vaso-occlusive crisis and frequency and severity of side effects following COVID-19 vaccination among patients at the Montefiore Sickle Cell Center for Adults. Read More

Front Immunol 2022 26;13:876776. Epub 2022 May 26.

Department of Pediatric Immunology, Rheumatology, and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands.

, the causative agent of meningococcal disease (MD), evades complement-mediated clearance upon infection by 'hijacking' the human complement regulator factor H (FH). The FH protein family also comprises the homologous FH-related (FHR) proteins, hypothesized to act as antagonists of FH, and FHR-3 has recently been implicated to play a major role in MD susceptibility. Here, we show that the circulating levels of all FH family proteins, not only FH and FHR-3, are equally decreased during the acute illness. Read More

J Bone Metab 2022 May 31;29(2):133-140. Epub 2022 May 31.

Department of Endocrinology, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México, Mexico.

Atypical parathyroid adenoma (APA) is a rare cause of primary hyperparathyroidism (PHPT) and represents a diagnostic challenge since it is an intermediate form of parathyroid neoplasm of uncertain malignant potential with atypical histological features that require differential diagnosis of parathyroid carcinoma (PC). We present 2 cases of parathyroid crisis as a presentation of APA. The first case was that of a 56-year-old man with parathyroid crisis, constitutional syndrome, and anemia, with evidence of APA after en bloc resection, evolving with hungry bone syndrome after surgery and curation criteria at 6 months after parathyroidectomy (PTX). Read More

Kidney Int 2022 Jun 16. Epub 2022 Jun 16.

Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Urine neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury that has been adapted to a urine dipstick test. However, there is limited data on its use in low-and-middle-income countries where diagnosis of acute kidney injury remains a challenge. To study this, we prospectively enrolled 250 children with sickle cell anemia aged two to 18 years encompassing 185 children hospitalized with a vaso-occlusive pain crisis and a reference group of 65 children attending the sickle cell clinic for routine care follow up. Read More

BMC Vet Res 2022 Jun 18;18(1):231. Epub 2022 Jun 18.

College of Veterinary Medicine, Shandong Agricultural University, No.61, Daizong Street, Taian, 271018, China.

Background: Gyrovirus homsa1 (GyH1) (also known as Gyrovirus 3, GyV3) is a non-enveloped, small, single-stranded DNA virus, which was first identified in children with acute diarrhea, and was subsequently detected in marketed chickens, broilers with transmissible viral proventriculitis (TVP), and mammals. GyH1 is a pathogenic virus in chickens, causing aplastic anemia, immunosuppression, and multisystem damage. However, the seroepidemiology of GyH1 infection in chickens remains unclear. Read More

Int J Cardiol 2022 Jun 15. Epub 2022 Jun 15.

Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. Electronic address:

Background: Persons with bipolar disorder (BD) have a higher cardiovascular mortality compared to the general population, partially explained by the increased burden of cardiovascular risk factors. Research regarding outcomes following acute coronary syndrome (ACS) in this population remains scarce.

Design: This Danish register-based study included patients diagnosed with BD and ACS in the period between January 1st, 1995, to December 31st, 2013. Read More

Elife 2022 Jun 17;11. Epub 2022 Jun 17.

Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, United States.

Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals involving cooperation between SCF/Kit signaling and other signaling inputs are required for the increased erythroid precursor activity in anemia. Our prior work revealed that the Sterile Alpha Motif (SAM) Domain 14 () gene increases the regenerative capacity of the erythroid system in a mouse genetic model and promotes stress-dependent Kit signaling. Read More