23,013 results match your criteria Anemia Acute


Clinical characteristics, histopathology, and tissue immunolocalization of chikungunya virus antigen in fatal cases.

Clin Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Centers for Disease Control and Prevention - Infectious Diseases Pathology Branch, Atlanta, Georgia, United States of America.

Background: Death in patients with chikungunya is rare, and has been associated with encephalitis, hemorrhage, and septic shock. We describe clinical, histologic and immunohistochemical findings in individuals who died following chikungunya virus (CHIKV) infection.

Methods: We identified individuals who died in Puerto Rico during 2014 following an acute illness, and had CHIKV RNA detected by RT-PCR in a pre- or post-mortem blood or tissue specimen. Read More

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http://dx.doi.org/10.1093/cid/ciaa837DOI Listing
July 2020
8.886 Impact Factor

Fatal complication of sickle cell anemia in an immigrant patient rescued from the mediterranean sea.

Clin Ter 2020 Jul-Aug;171(4):e291-e294

Department Pro.Mi.Se., University of Palermo.

The aim of this case report is to share with the forensic science community the experience of a rare complication of sickle cell anemia: acute chest syndrome. In October 2016, at the port of the city of Trapani (Sicily, Italy), the landing of an ONG "Médecins Sans Frontières" ship took place with 548 non-EU citizens and a corpse on board. The man, in the hours before his death, complained of severe chest pain and respiratory difficulties, and, despite of the therapeutic aids and resuscitation maneuvers, lastly died. Read More

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http://dx.doi.org/10.7417/CT.2020.2230DOI Listing

Incidence and risk factors associated with postoperative delirium following primary elective total hip arthroplasty: a retrospective nationwide inpatient sample database study.

BMC Psychiatry 2020 Jul 1;20(1):343. Epub 2020 Jul 1.

Department of Orthopaedic Surgery, Division of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 1838 Guangzhou Avenue, Guangzhou, 510515, Guangdong, China.

Background: Postoperative delirium is a common complication following major surgeries, leading to a variety of adverse effects. However, there is a paucity of literatures studying the incidence and risk factors associated with delirium after primary elective total hip arthroplasty (THA) using a large-scale national database.

Methods: A retrospective database analysis was performed based on Nationwide Inpatient Sample (NIS) from 2009 to 2014. Read More

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http://dx.doi.org/10.1186/s12888-020-02742-6DOI Listing

Predictors of time-to-recovery from severe acute malnutrition treated in an outpatient treatment program in health posts of Arba Minch Zuria Woreda, Gamo zone, Southern Ethiopia: A retrospective cohort study.

PLoS One 2020 30;15(6):e0234793. Epub 2020 Jun 30.

School of Public Health, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Southern Ethiopia.

Background: Access to outpatient therapeutic feeding programs for all children who had uncomplicated severe acute malnutrition (SAM) in need is a global health priority. In Ethiopia SAM is treated in hospitals, health centers and health posts. Health extension workers (HEWs) manage SAM that is uncomplicated at the health posts through the outpatient therapeutic feeding programs (OTP). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234793PLOS

Clinical and Epidemiological Features of SARS-CoV-2 Patients in SARI Ward of a Tertiary Care Centre in New Delhi.

J Assoc Physicians India 2020 Jul;68(7):19-26

Postgraduate Student (Medicine), ABVIMS and Dr Ram Manohar Lohia Hospital, New Delhi.

Importance: Rapid spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Wuhan, China, prompted heightened surveillance in India. Since the first laboratory confirmed case of SARS-CoV-2 was reported from Kerala on January 30, 2020 novel coronavirus infected pneumonia (NCIP) has been presenting to the hospital emergencies as severe acute respiratory illness (SARI). We aim to find out the rate of SARS-CoV-2 positivity in SARI cases and further clarify the epidemiological and clinical characteristics of NCIP in New Delhi, India. Read More

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Anaemia, iron deficiency and heart failure in 2020: facts and numbers.

ESC Heart Fail 2020 Jun 30. Epub 2020 Jun 30.

Department of Cardiology & Berlin Institute of Health Center for Regenerative Therapies (BCRT), German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Charité-Universitätsmedizin Berlin (Campus CVK), Berlin, Germany.

Anaemia is defined by WHO as Hb < 13.0 g/dL in male adults and <12.0 g/dL in female adults. Read More

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http://dx.doi.org/10.1002/ehf2.12797DOI Listing

Glucose-6-Phosphate Dehydrogenase Deficiency: An Actionable Risk Factor for Patients with COVID-19?

Arch Med Res 2020 Jun 7. Epub 2020 Jun 7.

Virginia Commonwealth University, Department of Internal Medicine, Richmond, VA, USA.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked mutation that is more prevalent in African, Asian, Latin American and Mediterranean populations. Although most individuals are asymptomatic, exposure to certain food, drugs, or infections can trigger acute hemolytic anemia. Given the potential for coronavirus to trigger oxidative stress, unrecognized G6PD deficiency in the presence of the COVID-19 viral infection may cause hemolytic crisis and worse outcome in affected individuals. Read More

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http://dx.doi.org/10.1016/j.arcmed.2020.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275985PMC

Pericardectomy after pericarditis constrictiva led to onset of transplant kidney function after 98 days of anuric kidney graft: a case report.

BMC Nephrol 2020 Jun 29;21(1):241. Epub 2020 Jun 29.

Department of Nephrology and Hypertension, University Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Germany.

Background: Constrictive pericarditis is easily overlooked and can lead to severe problems in hemodynamics and end-organ perfusion, in our patient leading to 98 days of anuria after living kidney transplantation. This was completely reversible after pericardectomy.

Case Presentation: A 43-year-old female caucasian patient received a living kidney donation from her mother. Read More

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http://dx.doi.org/10.1186/s12882-020-01899-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324971PMC

[Fatal severe community-acquired pneumonia: risk factors, clinical characteristics and medical errors of hospital patients].

Ter Arkh 2020 Apr 27;92(3):42-49. Epub 2020 Apr 27.

Kazan (Volga Region) Federal University.

Community-acquired pneumonia (CAP) is the most common disease and potentially life-threatening infection in the worldwide. In the Nizhny Novgorod region, no analysis of the causes of mortality and medical errors of severe CAP patients.

Aim: To analyze the patients structure who died severe CAP in hospitals of the Nizhny Novgorod region, to identify the leading risk factors, to assess the clinical characteristics of fatal severe CAP and medical errors according to medical records of patients from 20152016. Read More

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http://dx.doi.org/10.26442/00403660.2020.03.000538DOI Listing

The Economic Burden of End-Organ Damage Among Medicaid Patients with Sickle Cell Disease in the United States: A Population-Based Longitudinal Claims Study.

J Manag Care Spec Pharm 2020 Jun 29:1-9. Epub 2020 Jun 29.

Johns Hopkins University, Baltimore, Maryland.

Background: The management of sickle cell disease (SCD), an inherited, chronic, and multifaceted condition, is associated with considerable health care resource utilization (HRU) and costs, especially for Medicaid. Anemia affects most patients with SCD and correlates with end-organ damage (EOD), such as stroke, chronic kidney disease (CKD), end-stage renal disease (ESRD), and pulmonary hypertension (PH). Limited research has been conducted to quantify the economic burden of EOD among patients with SCD. Read More

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http://dx.doi.org/10.18553/jmcp.2020.20009DOI Listing

Tuberculosis Presenting as Hepatic and Splenic Microabscesses.

Cureus 2020 May 23;12(5):e8247. Epub 2020 May 23.

Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.

Tuberculosis (TB) is a major public health problem in developing countries. It can affect any organ of the body, and can have a multitude of clinical presentations. We present the case of a 22-year-old male who presented with fever, abdominal pain, and weight loss, and was found to have enlarged liver and spleen, both studded with multiple microabscesses. Read More

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http://dx.doi.org/10.7759/cureus.8247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308814PMC

Clinico-Hematological Findings of Acute Pediatric Visceral Leishmaniasis Referred to the Northeast of Iran during 2005-2015.

Iran J Parasitol 2020 Apr-Jun;15(2):214-222

Department of Laboratory Sciences, Maragheh University of Medical Sciences, Maragheh, Iran.

Background: To characterize the epidemiological, clinical, hematological and biochemical features of 33 cases hospitalized with pediatric visceral leishmaniasis (PVL) in North Khorasan Province of Iran from 2005 to 2015.

Methods: The serological, hematological and biochemical tests were employed in 33 children between 8 months to 6 yr with a final diagnosis of acute visceral leishmaniasis (VL). The diagnosis of VL was established by microscopic demonstration of spp. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311815PMC

Development of new cold antibodies in a patient with a history of warm autoimmune haemolytic anaemia.

BMJ Case Rep 2020 Jun 28;13(6). Epub 2020 Jun 28.

Hematology/Oncology, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

A 31-year-old male presented to our facility with complaints of shortness of breath and left-sided chest pain. On record review, it was revealed that he had been seen in 2014 for an almost identical presentation and had been found to have haemolytic anaemia with warm autoantibodies. Following his acute treatment during that hospital admission, he was lost to follow-up. Read More

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http://dx.doi.org/10.1136/bcr-2019-232224DOI Listing

Incidence and risk factors of in-hospital prosthesis-related complications following total hip arthroplasty: a retrospective Nationwide Inpatient Sample database study.

Int Orthop 2020 Jun 27. Epub 2020 Jun 27.

Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue, Guangzhou, 510515, Guangdong, China.

Purpose: The occurrence of prosthesis-related complications (PRCs) after total hip arthroplasty (THA) is devastating, commonly meaning implant failure and revision surgery. The purpose was to examine the incidence and risk factors of in-hospital PRCs following THA using a large-scale national database.

Methods: A retrospective database analysis was performed based on Nationwide Inpatient Sample (NIS) from 2005 to 2014. Read More

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http://dx.doi.org/10.1007/s00264-020-04682-yDOI Listing

Blood transfusion and ischaemic outcomes according to anemia and bleeding in patients with non-ST-segment elevation acute coronary syndromes: Insights from the TAO randomized clinical trial.

Int J Cardiol 2020 Jun 23. Epub 2020 Jun 23.

Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Paris-Diderot, Département Hospitalo-Universitaire FIRE, Sorbonne-Paris Cité, Paris, France; FACT (French Alliance for Cardiovascular clinical Trials), an F-CRIN network,l: NHLI, Royal Brompton Hospital, Imperial College, London, United Kingdom. Electronic address:

Background: The benefits and risks of blood transfusion in patients with acute myocardial infarction who are anemic or who experience bleeding are debated. We sought to study the association between blood transfusion and ischemic outcomes according to haemoglobin nadir and bleeding status in patients with NST-elevation myocardial infarction (NSTEMI).

Methods: The TAO trial randomized patients with NSTEMI and coronary angiogram scheduled within 72h to heparin plus eptifibatide versus otamixaban. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.020DOI Listing

Prognostic nutritional index in elderly patients hospitalized for acute heart failure.

ESC Heart Fail 2020 Jun 26. Epub 2020 Jun 26.

Department of Medical, Oral and Biotechnological Sciences, Gabriele D'Annunzio University, Chieti, Italy.

Aims: Acute heart failure (AHF) represents a frequent cause of hospitalization and is associated with significant mortality among elderly patients. Risk assessment models like the prognostic nutritional index (PNI) have been proposed to stratify the risk of death and identify patients requiring more intensive levels of care. We evaluated the predictive value of PNI for in-hospital and overall mortality in a cohort of consecutive elderly patients hospitalized for AHF. Read More

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http://dx.doi.org/10.1002/ehf2.12812DOI Listing

Management of Hemoglobin Disorders During the COVID-19 Pandemic.

Front Med (Lausanne) 2020 9;7:306. Epub 2020 Jun 9.

Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

The coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has become a global public health concern after being first reported in China and has subsequently spread worldwide. It causes mild to severe respiratory illness with some flu-like symptoms. The causal virus behind this disease, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), conceivably attacks the receptors of the respiratory system of the human body but has no strict evidence of attacking the blood cells yet. Read More

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http://dx.doi.org/10.3389/fmed.2020.00306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295899PMC

Extreme anorexia nervosa: medical findings, outcomes, and inferences from a retrospective cohort.

J Eat Disord 2020 23;8:25. Epub 2020 Jun 23.

ACUTE Center for Eating Disorders at Denver Health, 723 Delaware St, Pav M 3rd floor, Denver, CO 80204 USA.

Background: Extreme anorexia nervosa (AN) is defined as a BMI < 15 kg/m in those meeting DSM-V diagnostic criteria for AN. This study seeks to define the frequency of medical complications in this group of patients in order to help inform the care of individuals < 65% ideal body weight who seek treatment for their extreme eating disorders.

Methods: Through retrospective chart review and computerized data collection, we obtained the baseline characteristics and medical findings of 281 adult patients, with AN restricting and binge-purge subtypes, admitted to the ACUTE unit for medical stabilization between May 2013 and August 2018. Read More

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http://dx.doi.org/10.1186/s40337-020-00303-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310519PMC

Methemoglobinemia in Patient with G6PD Deficiency and SARS-CoV-2 Infection.

Emerg Infect Dis 2020 Jun 24;26(9). Epub 2020 Jun 24.

We report a case of intravascular hemolysis and methemoglobinemia, precipitated by severe acute respiratory syndrome coronavirus 2 infection, in a patient with undiagnosed glucose-6-phosphate dehydrogenase deficiency. Clinicians should be aware of this complication of coronavirus disease as a cause of error in pulse oximetry and a potential risk for drug-induced hemolysis. Read More

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http://dx.doi.org/10.3201/eid2609.202353DOI Listing

Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa.

N Engl J Med 2020 06;382(26):2524-2533

From the Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University, Indianapolis (C.C.J.); the Department of Pediatrics and Child Health, Makerere University (R.O.O., H.A.H., C.N., P.K., C.M.N.), Global Health Uganda (R.O.O., C.N.), and Mulago Hospital (P.K.) - all in Kampala, Uganda; the Division of Hematology, Department of Pediatrics (T.S.L., A.L., R.E.W.), and the Global Health Center (R.E.W.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (A.L., R.E.W.) - all in Cincinnati; and the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal (H.A.H.).

Background: Hydroxyurea has proven safety, feasibility, and efficacy in children with sickle cell anemia in sub-Saharan Africa, with studies showing a reduced incidence of vaso-occlusive events and reduced mortality. Dosing standards remain undetermined, however, and whether escalation to the maximum tolerated dose confers clinical benefits that outweigh treatment-related toxic effects is unknown.

Methods: In a randomized, double-blind trial, we compared hydroxyurea at a fixed dose (approximately 20 mg per kilogram of body weight per day) with dose escalation (approximately 30 mg per kilogram per day). Read More

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http://dx.doi.org/10.1056/NEJMoa2000146DOI Listing

Polyethylene Oxide (PEO) molecular size determines the severity of atypical thrombotic microangiopathy in a guinea pig model of acute intravenous exposure.

Toxicol Sci 2020 Jun 24. Epub 2020 Jun 24.

Department of Pathology, University of Maryland School of Medicine, Baltimore Maryland, USA.

In 2017, Opana ER was voluntarily removed from the US market based on concerns that its risks outweighed its therapeutic benefits. The data that supported this conclusion were based on post- marketing evaluation that demonstrated increased intravenous abuse associated outbreaks of HIV, hepatitis C and uniquely, a thrombotic thrombocytopenic purpura (TTP) like syndrome. In 2017, the cause was mechanistically linked to IV exposure of the high molecular weight polyethylene oxide (PEO), an excipient component of the drug product. Read More

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http://dx.doi.org/10.1093/toxsci/kfaa099DOI Listing

Trends, predictors, and outcomes associated with 30-day hospital readmissions after percutaneous coronary intervention in a high-volume center predominantly using radial vascular access.

Cardiovasc Revasc Med 2020 May 22. Epub 2020 May 22.

Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States of America. Electronic address:

Background And Aim: Patients undergoing percutaneous coronary intervention (PCI) are at high-risk for hospital readmission. We examined the rate, factors associated with, and outcomes of 30-day readmissions for patients who underwent a PCI.

Methods: We reviewed medical records of all patients who underwent PCI between 2011 and 2014 at a central New England radial first, tertiary care center. Read More

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http://dx.doi.org/10.1016/j.carrev.2020.05.017DOI Listing

Hereditary Predisposition to Hematopoietic Neoplasms: When Bloodline Matters for Blood Cancers.

Mayo Clin Proc 2020 Jun 19. Epub 2020 Jun 19.

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN. Electronic address:

With the advent of precision genomics, hereditary predisposition to hematopoietic neoplasms- collectively known as hereditary predisposition syndromes (HPS)-are being increasingly recognized in clinical practice. Familial clustering was first observed in patients with leukemia, which led to the identification of several germline variants, such as RUNX1, CEBPA, GATA2, ANKRD26, DDX41, and ETV6, among others, now established as HPS, with tendency to develop myeloid neoplasms. However, evidence for hereditary predisposition is also apparent in lymphoid and plasma--cell neoplasms, with recent discoveries of germline variants in genes such as IKZF1, SH2B3, PAX5 (familial acute lymphoblastic leukemia), and KDM1A/LSD1 (familial multiple myeloma). Read More

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http://dx.doi.org/10.1016/j.mayocp.2019.12.013DOI Listing

Tranexamic Acid Reduces the Rate of Periprosthetic Joint Infection After Aseptic Revision Arthroplasty.

J Bone Joint Surg Am 2020 Jun 19. Epub 2020 Jun 19.

Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Background: Revision total joint arthroplasty (TJA) has a higher rate of periprosthetic joint infection (PJI) compared with primary TJA, possibly as the result of increased allogeneic blood transfusion. Tranexamic acid (TXA) is gaining popularity in revision TJA to minimize blood loss and the need for transfusion; however, its effect on PJI reduction has yet to be investigated. The hypothesis of this study was that the administration of TXA during revision arthroplasty is protective against subsequent PJI. Read More

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http://dx.doi.org/10.2106/JBJS.19.00925DOI Listing

[Advances in molecular biology research on human parvovirus B19].

Sheng Wu Gong Cheng Xue Bao 2020 May;36(5):879-890

College of Medical, Hubei University of Arts and Science, Xiangyang 441053, Hubei, China.

Human parvovirus B19 (B19 virus) is one of the two parvoviruses that cause human diseases. As an important pathogen to humans, it causes infectious erythema in children, acute aplastic anemia, fetal edema and death. In this review, we focus on the recent advances in the molecular virology of B19V, such as viral genotypes, viral receptor, genomic features and viral replication, viral transcription and post-transcription regulation, viral nonstructural and structural protein features and functions, viral diagnosis and antiviral agents, to provide reference for further study of B19 pathogenesis mechanisms, treatment and diagnostic strategies. Read More

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http://dx.doi.org/10.13345/j.cjb.190380DOI Listing

Mycophenolic Acid Trough Concentration and Dose Are Associated with Hematologic Abnormalities but Not Rejection in Kidney Transplant Recipients.

J Korean Med Sci 2020 Jun 22;35(24):e185. Epub 2020 Jun 22.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.

Background: Little is known regarding the safe fixed dose of mycophenolic acid (MPA) for preventing biopsy-proven acute rejection (BPAR) in kidney transplant recipients (KTRs). We investigated the correlation of MPA trough concentration (MPA C₀) and dose with renal transplant outcomes and adverse events.

Methods: This study included 79 consecutive KTRs who received MPA with tacrolimus (TAC) and corticosteroids. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308135PMC

The toxicology of gallium oxide in comparison with gallium arsenide and indium oxide.

Authors:
Ernst M Bomhard

Environ Toxicol Pharmacol 2020 Jun 19;80:103437. Epub 2020 Jun 19.

REACh ChemConsult GmbH, Strehlener Str. 14, D-01069 Dresden, Germany. Electronic address:

Gallium arsenide (GaAs) and indium oxide (InO) are used in electronic industries at high and increasing tonnages since decades. Gallium oxide (GaO) is an emerging wide-bandgap transparent conductive oxide with as yet little industrial use. Since GaAs has received critical attention due to the arsenic ion, it seemed reasonable to compare its toxicology with the respective endpoints of GaO and InO toxicology in order to find out if and to what extent arsenic contributes. Read More

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http://dx.doi.org/10.1016/j.etap.2020.103437DOI Listing

Effect of Rehydration With Normal Saline Versus Ringer Lactate on Serum Sodium Level of Children With Acute Diarrhea and Severe Dehydration: A Randomized Controlled Trial.

Indian Pediatr 2020 Jun;57(6):519-522

Department of Pediatrics, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India. Correspondence to: Dr Raghvendra Singh, Associate Professor, Department of Pediatrics, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India.

Objective: To demonstrate the equivalence of Normal Saline (NS) and Ringer Lactate (RL) for change in serum sodium levels during correction of severe dehydration in children with acute diarrhea based on World Health Organization (WHO) plan C.

Design: Equivalence randomized control trial.

Setting: Pediatric diarrhea unit of a tertiary care hospital from May, 2016 to April, 2017. Read More

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High dose vitamin C induced methemoglobinemia and hemolytic anemia in glucose-6-phosphate dehydrogenase deficiency.

Am J Emerg Med 2020 Jun 1. Epub 2020 Jun 1.

Accident & Emergency Department, Ruttonjee and Tang Shiu Kin Hospital, Hong Kong.

Investigational use of intravenous vitamin C has been on the rise, but its side effects may be underreported. A 75-year-old woman presented with acute onset of jaundice, dark urine and shortness of breath after receiving 30 g of vitamin C infusion as an unconventional therapy for her hemifacial spasm. Diagnosis of methemoglobinemia and hemolytic anemia was made clinically and confirmed on laboratory tests. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.05.099DOI Listing

A novel G6PD gene variant in a Chinese girl with favism.

J Clin Lab Anal 2020 Jun 17:e23402. Epub 2020 Jun 17.

Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan City, China.

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The human G6PD gene is highly polymorphic, and over 200 mutations have been identified, many of which are associated with hemolytic anemia. Here, we analyzed the clinical genetics data of a Chinese girl with favism who developed acute hemolytic anemia after fava bean ingestion. Read More

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http://dx.doi.org/10.1002/jcla.23402DOI Listing

[New insights on a long-known element - iron, hepcidin and inflammation].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2020 Jun 18;48(3):183-190. Epub 2020 Jun 18.

Iron (Fe) is an essential trace element. In daily veterinary practice, it plays a pivotal role e. g. Read More

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http://dx.doi.org/10.1055/a-1162-0126DOI Listing

Outcomes of allogeneic haematopoietic stem cell transplantation for patients with severe aplastic anaemia using the porcine antilymphocyte globulin-containing conditioning regimen.

Ann Hematol 2020 Jun 17. Epub 2020 Jun 17.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie-fang Avenue, Wuhan, Hubei, 430030, People's Republic of China.

Antithymocyte globulin (ATG) is widely used for allogeneic haematopoietic stem cell transplantation (allo-HSCT) in severe aplastic anaemia (SAA). Only rabbit-ATG (r-ATG) and porcine-antilymphocyte globulin (p-ALG) are available in China, but the p-ALG-containing conditioning regimen for allo-HSCT in SAA has seldom been reported. In this study, we retrospectively evaluated the outcomes of 41 SAA patients receiving allo-HSCT with a p-ALG-containing conditioning regimen in our transplantation centre. Read More

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http://dx.doi.org/10.1007/s00277-020-04111-5DOI Listing

Pernicious anaemia: switch to oral B12 supplementation to reduce risk of covid-19 transmission.

Authors:
Amrit Takhar

BMJ 2020 06 17;369:m2383. Epub 2020 Jun 17.

Wansford and Kings Cliffe Practice, Wansford PE8 6PL, UK.

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http://dx.doi.org/10.1136/bmj.m2383DOI Listing

Fluoroscopy-guided endoscopic sclerotherapy: a novel hybrid approach for symptomatic rectosigmoidal venous malformation (with video).

Gastrointest Endosc 2020 Jun 15. Epub 2020 Jun 15.

Department of Internal Medicine I, Martin Luther University, Halle (Saale), Germany. Electronic address:

Background And Aims: Recommendations for the treatment of lower GI bleeding do not include bleeding from venous malformations (VM). The aim of this study was to delineate the usefulness of a novel hybrid intervention (fluoroscopy-guided endoscopic sclerotherapy) for the treatment of symptomatic VM in the rectosigmoidal colon with bleeding.

Methods: The MR images of 421 patients with VM, referred to multicenter vascular anomaly centers from 2009 to 2017, were analyzed retrospectively. Read More

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http://dx.doi.org/10.1016/j.gie.2020.06.027DOI Listing

Adrenal Insufficiency Secondary to Bilateral Adrenal Hemorrhage: A Case Report.

Cureus 2020 Jun 13;12(6):e8596. Epub 2020 Jun 13.

Diabetes and Endocrinology, Peterborough City Hospital, Peterborough, GBR.

Acute adrenal hemorrhage (adrenal apoplexy) in the context of severe sepsis is potentially life-threatening. Diagnosis of this condition is difficult to achieve without a strong sense of suspicion. The concurrent use of anticoagulants increases the risk of adrenal hemorrhage in the context of sepsis. Read More

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http://dx.doi.org/10.7759/cureus.8596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294864PMC

Impact of Acute Hemoglobin Falls in Heart Failure Patients: A Population Study.

J Clin Med 2020 Jun 15;9(6). Epub 2020 Jun 15.

Cardiovascular and Renal Research Group INCLIVA Research Institute University of Valencia, 46010 Valencia, Spain.

This study assessed the impact of acute hemoglobin (Hb) falls in heart failure (HF) patients. HF patients with repeated Hb values over time were included. Falls in Hb greater than 30% were considered to represent an acute episode of anemia and the risk of hospitalization and all-cause mortality after the first episode was assessed. Read More

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http://dx.doi.org/10.3390/jcm9061869DOI Listing

[Sickle cell disease].

Internist (Berl) 2020 Jul;61(7):754-758

Praxis Prof. Eber, München, Deutschland.

The term "sickle cell disease" covers a group of genetic blood disorders caused by sickle hemoglobin (HbS) alone or in combination with other variants of the β‑globin locus. Sickle cell disease occurs frequently in sub-Saharan Africa, but is also common in Turkey, Greece, Sicily, the Middle East, India, and the Americas. Polymerization of deoxygenated sickle hemoglobin leads to decreased deformability of red blood cells. Read More

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http://dx.doi.org/10.1007/s00108-020-00822-zDOI Listing

Alemtuzumab as a Therapy for Chronic Lung Allograft Dysfunction in Lung Transplant Recipients With Short Telomeres.

Front Immunol 2020 28;11:1063. Epub 2020 May 28.

Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, United States.

Alemtuzumab, a monoclonal antibody targeting CD52 that causes lymphocyte apoptosis, is a form of advanced immunosuppression that is currently used as a therapy for refractory acute cellular rejection and chronic lung allograft dysfunction in lung transplant recipients (1-3). Side effects of alemtuzumab include bone marrow suppression, infection, and malignancy. Whether alemtuzumab can be safely used in allograft recipients that have an increased propensity for bone marrow suppression due to telomeropathies is unknown. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270280PMC

Pernicious anaemia: self-administration of hydroxocobalamin in the covid-19 crisis.

Authors:
John Warren

BMJ 2020 06 16;369:m2380. Epub 2020 Jun 16.

Harlow CM17 0DX, UK.

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http://dx.doi.org/10.1136/bmj.m2380DOI Listing

Toxicological Studies of Hydroethanolic Leaf Extract of (Willd) Amin Ex C. Jeffrey on Wistar Rats.

J Med Food 2020 Jun 16. Epub 2020 Jun 16.

Department of Animal Physiology and Pharmacology, Faculty of Sciences, University of Lome, Lome, Togo.

(Asteraceae) is a widely used vegetable in West Africa. It is used in traditional healing of many diseases such as hypertension, anemia, diabetes, and bleeding. The aim of this study is to investigate the cytotoxicity and the acute and subacute (28 days) oral toxicity of hydroethanolic leaves extract on male Wistar rats. Read More

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http://dx.doi.org/10.1089/jmf.2019.0221DOI Listing

Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome.

Kidney Int 2020 Jun 12. Epub 2020 Jun 12.

Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, USA. Electronic address:

Atypical hemolytic uremic syndrome is an ultra-rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. Its pathogenesis is driven most frequently by dysregulated cell-surface control of the alternative pathway of complement secondary to inherited and/or acquired factors. Here we evaluated two unrelated patients with atypical hemolytic uremic syndrome. Read More

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http://dx.doi.org/10.1016/j.kint.2020.05.028DOI Listing

COVID-19 in a child with severe aplastic anemia.

Pediatr Blood Cancer 2020 08 15;67(8):e28443. Epub 2020 Jun 15.

Department of Pediatric Hematology, Ankara City Hospital Children's Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1002/pbc.28443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323031PMC

Thrombotic microangiopathy with renal injury: an approach for the general physician

J R Coll Physicians Edinb 2020 03;50(1):25-31

Department of Renal Medicine, Norfolk and Norwich University Hospital, Norwich, UK.

Thrombotic microangiopathy with renal dysfunction is a haematological and renal emergency warranting urgent diagnosis and intervention. As the potential underlying causes may be complex, assessment and management can be challenging for treating clinicians, and a timely and collaborative approach between general physicians, haematologists and nephrologists may be extremely helpful in order to optimise clinical outcomes. This paper will aim to build an understanding of different potential presentations of thrombotic microangiopathies and provide a practical framework for diagnosis and management, using a case-based discussion format, for acute and general physicians. Read More

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http://dx.doi.org/10.4997/JRCPE.2020.107DOI Listing

The Relationship between Vitamin D Levels and Iron Deficiency and Anemia in Adults Applied for Periodic Medical Examination.

Clin Lab 2020 Jun;66(6)

Background: Anemia and vitamin D deficiency are two important public health issues that may accompany many acute and chronic diseases. Several studies conducted in recent years have suggested that vitamin D deficiency is associated with anemia in healthy and patient populations. The aim of the study is to investigate the relationship between vitamin D deficiency and anemia. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.190918DOI Listing

Initial dosage optimization of ciclosporin in pediatric Chinese patients who underwent bone marrow transplants based on population pharmacokinetics.

Exp Ther Med 2020 Jul 8;20(1):401-408. Epub 2020 May 8.

Department of Pharmacy, Children's Hospital of Fudan University, Shanghai 201102, P.R. China.

Bone marrow transplants (BMT) are an established therapeutic strategy for patients with severe aplastic anemia, acute lymphoblastic leukemia, acute myeloid leukemia or chronic myeloid leukemia. However, the successful application of BMT is limited by graft-vs.-host disease (GVHD). Read More

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http://dx.doi.org/10.3892/etm.2020.8732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282146PMC

Occupational Lead Poisoning in a Patient with Acute Abdomen and Normocytic Anemia.

Intern Med 2020 15;59(12):1565-1570. Epub 2020 Jun 15.

Department of Internal Medicine, Uwajima City Hospital, Japan.

We herein report a 24-year-old male construction worker with occupational lead poisoning who presented with acute abdomen and normocytic anemia. The levels of urinary delta-aminolevulinic acid and free erythrocyte protoporphyrin were elevated without any increase in the level of urine porphobilinogen. Detection of an elevated blood lead level of 100 μg/dL confirmed a diagnosis of lead poisoning. Read More

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http://dx.doi.org/10.2169/internalmedicine.4176-19DOI Listing

The New CIC Mutation Associates with Mental Retardation and Severity of Seizure in Turkish Child with a Rare Class I Glucose-6-Phosphate Dehydrogenase Deficiency.

J Mol Neurosci 2020 Jun 13. Epub 2020 Jun 13.

Biruni University, Zeytinburnu, Istanbul, Turkey.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive disease that causes acute or chronic hemolytic anemia and potentially leads to severe jaundice in response to oxidative agents. Capicua transcriptional repressor (CIC) is an important gene associated with mental retardation, autosomal dominant 45. Affiliated tissues including skin, brain, bone, and related phenotypes are intellectual disability and seizures. Read More

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http://dx.doi.org/10.1007/s12031-020-01614-8DOI Listing

Anaemia is associated with severe RBC dysfunction and a reduced circulating NO pool: vascular and cardiac eNOS are crucial for the adaptation to anaemia.

Basic Res Cardiol 2020 Jun 12;115(4):43. Epub 2020 Jun 12.

Department of Cardiology, Pulmonary Diseases, and Vascular Medicine, Medical Faculty, CARID Cardiovascular Research Institute of Duesseldorf, Heinrich Heine University of Duesseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.

Anaemia is frequently present in patients with acute myocardial infarction (AMI) and contributes to an adverse prognosis. We hypothesised that, besides reduced oxygen carrying capacity, anaemia is associated with (1) red blood cell (RBC) dysfunction and a reduced circulating nitric oxide (NO) pool, (2) compensatory enhancement of vascular and cardiac endothelial nitric oxide synthase (eNOS) activity, and (3) contribution of both, RBC dysfunction and reduced circulatory NO pool to left ventricular (LV) dysfunction and fatal outcome in AMI. In mouse models of subacute and chronic anaemia from repeated mild blood loss the circulating NO pool, RBC, cardiac and vascular function were analysed at baseline and in reperfused AMI. Read More

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http://dx.doi.org/10.1007/s00395-020-0799-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293199PMC