213,136 results match your criteria Anemia Acute


Maternal anaemia and maternal, foetal and neonatal outcomes in a prospective cohort study in India and Pakistan.

BJOG 2018 Dec 16. Epub 2018 Dec 16.

Thomas Jefferson University, 130 S 9th St, Philadelphia, PA, 19107, USA.

Objective: To describe the association of maternal anaemia with maternal, foetal and neonatal outcomes.

Design: Prospective cohort study.

Setting: Rural India and Pakistan. Read More

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December 2018

Triple therapy at discharge from internal medicine wards in heart failure patients with reduced ejection fraction: results from an observational study.

Clin Ter 2018 Nov-Dec;169(6):e287-e291

Internal Medicine, San Giuseppe Hospital, Empoli (Firenze), Italy.

Background: Guidelines recommend triple therapy (TT) with ACE inhibitors or ARBs, beta-blockers and mineralcorticoid receptor antagonists in symptomatic heart failure patients with ejection fraction <35 % (HFrEF). Nevertheless, many patients remain untreated. This study was aimed to evaluate the use of TT in HFrEF patients discharged from internal medicine wards of Tuscany, Italy. Read More

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December 2018

Giant-cell arteritis without cranial manifestations presenting as fever of unknown origin: a diagnostic value of 18F-FDG PET/CT.

Clin Ter 2018 Nov-Dec;169(6):e274-e276

Department of Infectious Diseases, Military Medical Academy, Sofia, Bulgaria.

We present a case of 68-year-old female with four months history of fever, fatigue, and weight loss. She was classified as case of fever of unknown origin. The physical examination was normal, the laboratory tests showed anemia, elevation of C-reactive protein, erythrocyte sedimentation rate and fibrinogen. Read More

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December 2018
3 Reads

Isolated Ascites in a Monochorionic Twin after Fetoscopic Laser Ablation Is Not Necessarily Secondary to Recurrence or Anaemia: Bowel Complications in Twin-to-Twin Transfusion Syndrome after Fetoscopic Laser Ablation.

Fetal Diagn Ther 2018 Dec 14:1-10. Epub 2018 Dec 14.

Fetal Medicine Centre, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom.

Background/purpose: We report a case study of jejunal atresia and the results of a systematic literature review of all reported cases of bowel complications occurring after fetoscopic laser ablation (FLA) for the treatment of twin-to-twin transfusion syndrome (TTTS).

Methods: A systematic literature review was performed of bowel complications after FLA for TTTS according to PRISMA guidelines.

Results: There are 11 published cases of small bowel atresia, 5 cases of necrotising enterocolitis (NEC), and 2 cases with foetal bowel perforations. Read More

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December 2018

[Hemodialysis performance in Center East Tunisia: Compliance and adequacy of biological tests (PHCET study 2014)].

Rev Epidemiol Sante Publique 2018 Dec 12. Epub 2018 Dec 12.

Unité de recherche « Mesure de performance hospitalière : UR12 SP36 », Direction des systèmes d'information, CHU Sahloul, Sousse, Tunisie.

Background: Determining the performance level of hemodialysis facilities, including an evaluation of biological tests, is a prerequisite for quality assessment of these healthcare structures.

Objective: The purpose of this work was to evaluate the compliance and adequacy of biological tests performed in 2014 in Center-East Tunisia hemodialysis units.

Methods: Data were collected using an analysis grid for 15 biological indicators including 11 process items and four results items used to determine the compliance and adequacy rates respectively. Read More

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December 2018

Modification of the bone marrow MSC population in a xenograft model of early multiple myeloma.

Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.

Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, 14 Medical Drive, #12-01, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City, 860-0811, Japan. Electronic address:

Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of abnormal plasma cells. MM dysregulates the homeostasis of the bone niche cells like osteoclasts and osteoblasts, responsible for the bone maintenance leading to bone loss and hypercalcemia, as well as the normal immune cells leading to immunodeficiency and anemia. Osteoblasts are part of the cell population differentiating from mesenchymal stem cells (MSC). Read More

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December 2018

Feasibility of transcatheter prosthetic paravalvular leakage closure: a single-center, exploratory safety evaluation study of transcatheter closure of prosthetic paravalvular regurgitation in Japan (STOP PARA study).

Gen Thorac Cardiovasc Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Japan.

Objective: The standard treatment of prosthetic paravalvular leakage (PVL) accompanied by heart failure or hemolytic anemia is repeat open surgery. Although favorable outcomes for transcatheter prosthetic PVL closure in patients with a high surgical risk for repeat open surgery have been reported, procedural feasibility has not been examined in Japan.

Methods: From March 2015 to November 2015, transcatheter PVL closure in mitral position was performed in four patients (age range 41-78, three females) with high surgical risk due to history of repeated surgeries, chest radiation and reconstruction of the mitral annulus after debridement of abscess owing to infective endocarditis. Read More

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December 2018
2 Reads

Correction to: Structural modeling of a novel TERC variant in a patient with aplastic anemia and short telomeres.

Ann Hematol 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Medical Genetics, Bambino Gesù Children's Hospital, Rome, Italy.

The original version of this article contained a mistake in the affiliation of E. Bellacchio. Correct affiliation is presented here. Read More

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December 2018

Challenging diagnosis of congenital malaria in non-endemic areas.

Malar J 2018 Dec 14;17(1):470. Epub 2018 Dec 14.

Unit of Parasitology, Bambino Gesù Children's Hospital, Piazza Sant'Onofrio 4, 00165, Rome, Italy.

Background: Congenital malaria is usually defined as the detection of asexual forms of Plasmodium spp. in a blood sample of a neonate during perinatal age if there is no possibility of postpartum infection by a mosquito bite. The incidence of congenital malaria is highly variable and seems related to several factors, such as different diagnostic methods for Plasmodium spp. Read More

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December 2018

Cardiac and pulmonary toxicity of mesoporous silica nanoparticles is associated with excessive ROS production and redox imbalance in Wistar rats.

Biomed Pharmacother 2019 Jan 3;109:2527-2538. Epub 2018 Dec 3.

Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Egypt.

Mesoporous silica nanoparticles (MSNs) represent one of the most promising drug delivery systems. MSNs have attracted considerable attention in recent years both in industry and biomedicine due to their unique properties. Thus, evaluation of the toxic effects of MSNs is necessary before the biomedical and clinical applications. Read More

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January 2019

Predicting peripartum blood transfusion in women undergoing cesarean delivery: A risk prediction model.

PLoS One 2018 14;13(12):e0208417. Epub 2018 Dec 14.

Department of Surgery, George Washington University, Washington, DC, United States of America.

Objective: There has been an appreciable rise in postpartum hemorrhage requiring blood transfusions in the United States. Our objective is to better define patients at greatest risk for peripartum transfusion at the time of cesarean in order to identify cases for early intervention and monitoring.

Methods: Our study is a secondary analysis of a retrospective cohort study. Read More

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December 2018

Prevalence and correlates of anemia among adolescents in Nepal: Findings from a nationally representative cross-sectional survey.

PLoS One 2018 14;13(12):e0208878. Epub 2018 Dec 14.

Department of Paediatrics, the University of Melbourne, Melbourne, Australia.

Anemia is regarded as major public health problem among adolescents in Low and Middle-Income Countries (LMICs) but there is limited primary data in many countries, including Nepal. This study investigated the prevalence and correlates of anemia in a nationally representative sample of adolescents within the 2014 National Adolescent Nutrition Survey in Nepal. A total of 3780 adolescents aged 10 to 19 years were selected from a cross-sectional survey through multi-stage cluster sampling. Read More

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December 2018

Atypical Prenatal Ultrasound Presentation and Neuropathological Findings in a Neonate With Alpha Thalassemia Major: A Case Report.

Pediatr Dev Pathol 2018 Dec 14:1093526618817655. Epub 2018 Dec 14.

1 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada.

Alpha thalassemia major is a hemoglobinopathy caused by the inactivation or deletion of all 4 α-globin alleles. We describe a case of α-thalassemia major with atypical ultrasound and neuropathological findings. The mother had her first prenatal visit at 27 4/7 gestational weeks. Read More

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December 2018

Tolerability and effectiveness of generic direct-acting antiviral drugs in eradication of hepatitis C genotype 4 among Egyptian patients.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University Cairo, Egypt.

Background: We investigated tolerability and effectiveness of generic, less expensive direct antiviral drugs in the treatment of hepatitis C virus genotype 4(HCV- GT-4) in an Egyptian cohort.

Patients And Methods: Retrospectively, we analyzed data from 648 patients with HCV-GT4 attending Alexandria Main University Hospital from January 2016 to May 2017 [488 treatment naïve/160 treatment experienced/288 with chronic hepatitis/360 with cirrhosis]. Patients received generic sofosbuvir/ledipasvir (n= 168, treatment naïve = 136, treatment-experienced = 32) or sofosbuvir/daclatasvir (n= 480, treatment naïve = 352, treatment-experienced = 128) ± ribavirin. Read More

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December 2018

Efficacy and safety of sofosbuvir-based therapy in hepatitis C virus recurrence post living donor liver transplant: A real life egyptian experience.

J Med Virol 2018 Dec 14. Epub 2018 Dec 14.

Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background And Aim: Direct acting antiviral has offered treatment of hepatitis C virus (HCV) recurrence post liver transplantation (LT) with an all-oral regimen for short duration, excellent safety profile, and high sustained virological response (SVR). The aim of this study was to evaluate the efficacy and safety of sofosbuvir (SOF)-based regimens in the real world among a cohort of Egyptian patients with recurrent HCV post living donor LT (LDLT).

Methods: Patients with HCV-G4 recurrence post-LDLT were recruited from National Committee of Control of Viral Hepatitis, Egypt, from November 2014 to May 2017. Read More

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December 2018

Clinical effectiveness and safety of erythropoietin-stimulating agents for the treatment of low- and intermediate-1-risk myelodysplastic syndrome: a systematic literature review.

Br J Haematol 2018 Dec 13. Epub 2018 Dec 13.

Service d'Hématologie Clinique, Hôpital St. Louis and Paris 7 University, Paris, France.

Many patients with lower-risk myelodysplastic syndrome (MDS) experience anaemia, which has negative consequences. Erythropoiesis-stimulating agents (ESAs) and their biosimilars are used to treat anaemia in MDS and, currently, epoetin alfa and darbepoetin alfa are commonly used and recommended by clinical guidelines. To better understand the evidence available on the use of ESAs for anaemia in lower-risk MDS, we conducted a systematic literature review to identify randomized and nonrandomized prospective studies reporting on clinical efficacy/effectiveness, patient-reported quality of life (QoL), and safety. Read More

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December 2018

Sofosbuvir Plus Ribavirin for the Treatment of Hepatitis C Virus Genotype 2 in Korea: What's the optimal dosage of ribavirin in real-world setting?

J Dig Dis 2018 Dec 10. Epub 2018 Dec 10.

Department of Internal Medicine, Mokpo Hankook Hospital, Mokpo, South Korea.

Aim: The objectives of this study were to examine the efficacy and safety of sofosbuvir plus ribavirin therapy for the treatment of hepatitis C virus genotype 2 infection and to determine the optimal ribavirin dosage.

Methods: From May 2016 to March 2017, 199 patients received sofosbuvir plus ribavirin treatment for hepatitis C virus genotype 2 infection at four centers in Jeollanam-do. After excluding patients lost to follow-up and those with insufficient data, we retrospectively assessed the data for 194 patients. Read More

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December 2018

Undiagnosed cardiac deficits in non-small cell carcinoma patients in the candidate population for anti-cachexia clinical trials.

Support Care Cancer 2018 Dec 13. Epub 2018 Dec 13.

Department of Oncology, Division of Palliative Care Medicine, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada.

Purpose: Currently, there is no approved therapy for cancer cachexia. According to European and American regulatory agencies, physical function improvements would be approvable co-primary endpoints of new anti-cachexia medications. As physical functioning is in part dependent on cardiac functioning, we aimed to explore the cardiac status of a group of patients meeting current criteria for inclusion in cachexia clinical trials. Read More

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December 2018

Prevalence of geophagy and knowledge about its health effects among native Sub-Saharan Africa, Caribbean and South America healthy adults living in France.

Eat Weight Disord 2018 Dec 13. Epub 2018 Dec 13.

Service de Médecine Interne et des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Reims, 51092, Reims, France.

Geophagy is widespread among women from Sub-Saharan Africa, South America and the Caribbean and may persist in western countries. This practice may be associated with adverse effects such as anaemia, constipation or intestinal occlusion. We aimed to determine the prevalence of geophagy and the level of knowledge about its health effects among healthy adults originating from these countries and attending a travel medicine and international vaccination consultation in France. Read More

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December 2018
1 Read

An Uncommon Presentation of Leiomyoma Cecum as a Subcutaneous Abscess of the Right Flank.

Cureus 2018 Oct 9;10(10):e3432. Epub 2018 Oct 9.

Otolaryngology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Cecal leiomyomas are rare benign tumors of smooth muscle arising from the colonic muscularis mucosa or muscularis propria. They are usually asymptomatic in nature and, if symptomatic, may present as pain in the abdomen, intestinal obstruction, or bleeding. In some cases, leiomyoma can cause free perforation leading to peritonitis. Read More

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October 2018
2 Reads

A Rare Pathological Couplet of Colocolic Intussusception Plus Cecal Bascule in a Young Adult: A Case Report.

Cureus 2018 Oct 9;10(10):e3430. Epub 2018 Oct 9.

Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, AUS.

This report is of a rare case involving a 27-year-old female who presented to the hospital with the pathological couplet of colocolic intussusception and cecal bascule causing bowel obstruction. Up to the time of presentation to the hospital, this patient had not undergone a full investigation for a known iron deficiency, anemia. Subsequently, during the emergency admission and after having an operative surgical procedure, the patient was found to have both a congenitally malpositioned cecum and a benign colonic polyp-forming condition. Read More

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October 2018

Methylation level of Rap1GAP and the clinical significance in MDS.

Oncol Lett 2018 Dec 26;16(6):7287-7294. Epub 2018 Sep 26.

Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, Jiangsu 215006, P.R. China.

Previous studies on the pathogenesis of myelodysplastic syndrome (MDS) have identified multiple associated gene mutations, including mutations of tetmethylcytosinedioxygenase 2, isocitrate dehydrogenase [NADP(+)] 1 cytosolic, isocitrate dehydrogenase [NADP(+)] 2 mitochondrial and additional sex combs like 1 transcriptional regulator, all of which may be considered epigenetic regulators. Furthermore, mutations of RAS type GTPase family genes have been identified in 10-15% patients with MDS. The authors' previous study on the gene expression profile of cluster of differentiation 34 cells using microarray analysis identified elevated expression of RAP1GTPase activating protein 1 (Rap1GAP) in patients with MDS compared with that in non-malignant blood diseases (NM) control group. Read More

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December 2018
2 Reads

Treatment of metastatic non-small cell lung cancer with NY-ESO-1 specific TCR engineered-T cells in a phase I clinical trial: A case report.

Oncol Lett 2018 Dec 1;16(6):6998-7007. Epub 2018 Oct 1.

Department of Research and Development, Shenzhen Institute for Innovation and Translational Medicine, Shenzhen, Guangdong 518120, P.R. China.

This article presented a case of a human leukocyte antigen (HLA)-A2-positive patient with advanced cancer/testis antigen New York esophageal squamous cell carcinoma-1 (NY-ESO-1) expressing lung adenocarcinoma (LADC) who received adoptive cell therapy of T cell receptor engineered-T cells (TCR-T cells) targeting the cancer-testis antigen NY-ESO-1. The appropriate clinical and laboratory assessments were conducted to investigate the safety and efficacy of this therapy for this lung cancer patient. The patient had a clinical response to and was well-tolerated with this therapy in the clinical trial. Read More

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December 2018
0.987 Impact Factor

Clinical diagnosis of adult patients with acute megakaryocytic leukemia.

Oncol Lett 2018 Dec 25;16(6):6988-6997. Epub 2018 Sep 25.

Worldwide Medical Center, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.

Acute megakaryocytic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML), which is challenging to diagnose due to frequent myelofibrosis (MF) and a low percentage of blast cells. In the present study, clinical characteristics and experimental observations in 9 adult patients diagnosed with AMKL, who were recruited by the Sino-U.S. Read More

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December 2018

Bone Marrow Fat and Hematopoiesis.

Front Endocrinol (Lausanne) 2018 28;9:694. Epub 2018 Nov 28.

Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.

Bone marrow fat cells comprise the largest population of cells in the bone marrow cavity, a characteristic that has attracted the attention of scholars from different disciplines. The perception that bone marrow adipocytes are "inert space fillers" has been broken, and currently, bone marrow fat is unanimously considered to be the third largest fat depot, after subcutaneous fat and visceral fat. Bone marrow fat (BMF) acts as a metabolically active organ and plays an active role in energy storage, endocrine function, bone metabolism, and the bone metastasis of tumors. Read More

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November 2018

Adverse Drug Reaction Onsets in Uganda's VigiBase: Delayed International Visibility, Data Quality and Illustrative Signal Detection Analyses.

Pharmaceut Med 2018 17;32(6):413-427. Epub 2018 Nov 17.

3MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

Introduction: Developing countries can improve their pharmacovigilance systems by analysing their own medication safety data.

Objective: The aims of this study were to characterize Uganda's reported adverse drug reaction (ADR) onsets in 2012-2015 that were registered on VigiBase by 31 December 2017, to document delays in international visibility and the influence of covariates on this delay from ADR onsets in 2013 + 2014, to examine data quality, and to illustrate analytical approaches for safety data, particularly for patients receiving antiretroviral therapy (ART).

Methods: International delay was defined as elapsed time from complete ADR onset date to entry date on VigiBase, with covariates examined using Cox proportional hazards regression. Read More

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November 2018
1 Read

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells.

Cell Death Differ 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, South Korea.

Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent activator of the sphingomyelinase (SMase)/ceramide pathway leading to ceramide synthesis and regulating cell differentiation, proliferation, apoptosis, senescence, and autophagy. Here we evaluated the implication of the TNFα/SMase/ceramide pathway on inhibition of erythropoiesis in human CD34 hematopoietic stem/progenitor cells (CD34/HSPCs) from healthy donors. Read More

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December 2018
2 Reads

The Hematopoietic Cell Transplant Comorbidity Index predicts survival after allogeneic transplant for non-malignant diseases.

Blood 2018 Dec 13. Epub 2018 Dec 13.

Fred Hutchinson Cancer Research Center, Seattle, WA, United States;

Despite overall improvements, mortality after allogeneic hematopoietic cell transplantation (HCT) for non-malignant diseases remains a significant problem. We evaluated whether pre-HCT conditions defined by the HCT Comorbidity Index (HCT-CI), predicts probability of post-transplant survival in these patients. Using the Center for International Blood and Marrow Transplant Research (CIBMTR) database, we identified 4,083 patients with non-malignant diseases transplanted between 2007-2014. Read More

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December 2018

First trimester ferritin screening for pre-delivery anaemia as a patient blood management strategy.

Transfus Apher Sci 2018 Dec 5. Epub 2018 Dec 5.

Centenary Hospital for Women and Children Yamba Drive Garran ACT, 2605, Australia.

Objectives: To determine the optimum approach and timing to screen for iron deficiency in pregnancy.

Background: There is a lack of consensus on identifying and treating iron deficiency during pregnancy. Patient blood management programs may be refined by evaluating outcomes. Read More

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December 2018

Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.

J Hematol Oncol 2018 Dec 13;11(1):137. Epub 2018 Dec 13.

CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.

Background: Human myeloma cell lines (HMCLs) are widely used for their representation of primary myeloma cells because they cover patient diversity, although not fully. Their genetic background is mostly undiscovered, and no comprehensive study has ever been conducted in order to reveal those details.

Methods: We performed whole-exon sequencing of 33 HMCLs, which were established over the last 50 years in 12 laboratories. Read More

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December 2018

Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study.

Malar J 2018 Dec 13;17(1):467. Epub 2018 Dec 13.

Department of Pathology and Medicine, Massachusetts General Hospital, Boston, MA, USA.

Background: Evolutionary pressure by Plasmodium falciparum malaria is known to have favoured a large number of human gene adaptations, but there is surprisingly little investigation of the effect of malaria on human mitochondrial sequence variation. Plasmodium falciparum infection can cause severe malaria anaemia (SMA) with insufficient tissue oxygenation, lactic acidosis and death. Despite equal degrees of severe anaemia, some individuals develop lactic acidosis while others do not. Read More

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December 2018

Iron supplementation during pregnancy - a cross-sectional study undertaken in four German states.

BMC Pregnancy Childbirth 2018 Dec 13;18(1):491. Epub 2018 Dec 13.

Department of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.

Background: Iron deficiency but also iron overload during pregnancy has been associated with unwanted health effects. In Germany, iron supplements are only recommended for pregnant women with diagnosed iron deficiency/anaemia. Prevalence of anaemia among pregnant women was reported at 24. Read More

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December 2018

Association between Hemoglobin and Hemoglobin A: A Data-Driven Analysis of Health Checkup Data in Japan.

J Clin Med 2018 Dec 12;7(12). Epub 2018 Dec 12.

Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto 606-8501, Japan.

Background: Interpretation of hemoglobin A (HbA) levels may be confounded by spurious results in anemic persons, but its degree is not well-established.

Methods: We used an employer-based health insurance database, containing health checkup data and medical claims data; both were linked via a unique identifier of each beneficiary. This study included persons aged 18⁻75 years who participated in health checkups, with a confirmed or suspected diagnosis of diabetes. Read More

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December 2018

Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases.

Pharmaceuticals (Basel) 2018 Dec 11;11(4). Epub 2018 Dec 11.

Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Inflammation, being a hallmark of many chronic diseases, including cancer, inflammatory bowel disease, rheumatoid arthritis, and chronic kidney disease, negatively affects iron homeostasis, leading to iron retention in macrophages of the mononuclear phagocyte system. Functional iron deficiency is the consequence, leading to anemia of inflammation (AI). Iron deficiency, regardless of anemia, has a detrimental impact on quality of life so that treatment is warranted. Read More

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December 2018

Iron Treatment May Be Difficult in Inflammatory Diseases: Inflammatory Bowel Disease as a Paradigm.

Nutrients 2018 Dec 11;10(12). Epub 2018 Dec 11.

Digestive Diseases Service, Hospital Clínico Universitario "Lozano Blesa", Zaragoza, 50009 Aragón, Spain.

Iron plays a key role in many physiological processes; cells need a very exact quantity of iron. In patients with inflammatory bowel disease, anaemia is a unique example of multifactorial origins, frequently being the result of a combination of iron deficiency and anaemia of chronic disease. The main cause of iron deficiency is the activity of the disease. Read More

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December 2018
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Metabolic Signature of Dietary Iron Overload in a Mouse Model.

Cells 2018 Dec 11;7(12). Epub 2018 Dec 11.

Department of Internal Medicine II, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.

Iron is an essential co-factor for several metabolic processes, including the Krebs cycle and mitochondrial oxidative phosphorylation. Therefore, maintaining an appropriate iron balance is essential to ensure sufficient energy production and to avoid excessive reactive oxygen species formation. Iron overload impairs mitochondrial fitness; however, little is known about the associated metabolic changes. Read More

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December 2018
1 Read

Clinical and Molecular Features of Feline Foamy Virus and Feline Leukemia Virus Co-Infection in Naturally-Infected Cats.

Viruses 2018 Dec 11;10(12). Epub 2018 Dec 11.

Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.

Feline foamy virus (FFV) and feline leukemia virus (FeLV) belong to the family. While disease has not been reported for FFV infection, FeLV infection can cause anemia and immunosuppression (progressive infection). Co-infection with FFV/FeLV allows evaluation of the pathogenic potential and epidemiology of FFV infection in cats with FeLV pathology. Read More

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December 2018

The Effect of Carbon Monoxide on the Exergy Behavior of the Lungs.

Bioengineering (Basel) 2018 Dec 7;5(4). Epub 2018 Dec 7.

School of Mechanical Engineering, University of Campinas, Campinas 13083-970, Brazil.

The present work evaluates the impact of carbon monoxide (CO) inhalation on the human lung's exergy behavior by considering different levels of intoxication and amounts of hemoglobin. Its impact is significant because CO is one of the most common air pollutants in cities and an increase in destroyed exergy may be correlated with lifespan reduction or the malfunctioning of certain human organs. An evaluation of the severity of intoxication as a function of city altitude may intensify the hazard associated with carbon monoxide. Read More

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December 2018

Minimally invasive surgery for inflammatory myofibroblastic tumor of the urinary bladder: Three case reports.

Medicine (Baltimore) 2018 Dec;97(49):e13474

Department of Urology, Institute of Urology, West China Hospital, Sichuan University.

Rationale: Inflammatory myofibroblastic tumors of the urinary bladder (IMTUB) is exceptionally rare. Currently, no standardized treatment has been established for IMTUBs.

Patient Concerns: Herein we report three cases presenting with hematuria and anemia. Read More

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December 2018

The risk of inflammatory bowel disease in subjects presenting with perianal abscess: findings from the THIN database.

J Crohns Colitis 2018 Dec 13. Epub 2018 Dec 13.

Department of Gastroenterology, Sandwell and West Birmingham Hospitals NHS Trust, UK.

Background: Perianal abscess (PA) is associated with inflammatory bowel disease (IBD). The incidence of IBD after a diagnosis of PA and potential predictors of a future diagnosis of IBD are unknown.

Methods: The Health Improvement Network (THIN) is a primary care database representative of the UK population. Read More

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December 2018

Development of a loop-mediated isothermal amplification assay for the detection of chicken anemia virus.

Poult Sci 2018 Dec 13. Epub 2018 Dec 13.

Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.

Chicken anemia virus (CAV) infection has been reported in various poultry industries worldwide. Since CAV infection is becoming increasingly prevalent, especially in local chickens of China, rapid CAV detection has become essential. The conventional diagnostic methods are time consuming and need special expertise. Read More

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December 2018

The Effect of Citrate on Clot Formation, Dialyzer Reuse, and Anemia in Hemodialysis Patients.

Blood Purif 2018 Dec 13:1-8. Epub 2018 Dec 13.

Renal Unit, Department of Medical, Faculty of Medicine, Navamindradhiraj University, Bangkok, Thailand.

Background: Citrate anticoagulation is increasingly favored for preventing extracorporeal circuit clotting during renal replacement therapy. This study tested the effect of citrate compared with acetate on heparin avoidance and other parameters.

Methods: Sixty-one chronic hemodialysis (HD) patients were switched from conventional dialysis fluid (acetate) to citrate dialysis fluid and were treated in 3 phases, each lasting 4 weeks: 50%, 25%, and no heparin. Read More

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December 2018
1 Read

Relapsing Evans syndrome and systemic lupus erythematosus with antiphospholipid syndrome treated with Bortezomib in combination with plasma exchange.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Laboratory of the Mosaics of Autoimmunity, Saint-Petersburg University, 7/9 Universitetskaya Emb., Saint- Petersburg 199034, Russia.

Relapsing Evans syndrome (ES) and systemic lupus erythematosus (SLE) with secondary antiphospholipid syndrome (APS) is very rare association. Coexistence of these syndromes is potentially fatal and require high-dose combined immunosuppressive therapy. We describe a case of successful use of Bortezomib and plasma exchange in a patient with ES and APS refractory to standard therapy. Read More

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December 2018

[A Case of Refractory Hemorrhagic Cystitis in which Bleeding Control was Finally Achieved by Cystectomy].

Hinyokika Kiyo 2018 Oct;64(10):415-418

Hakodate Goryokaku Hospital.

A 60-year-old man presented at our hospital with gross hematuria. He had been treated for nephrotic syndrome with cyclophosphamide and steroids since he was in his 20s. We detected diffuse hemorrhagic cystitis on cystoscopy and diagnosed him with cyclophosphamide-induced hemorrhagic cystitis. Read More

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October 2018

[Renal Pelvic Cancer with Delayed Diagnosis Due to Left Renal Injury : A Case Report].

Hinyokika Kiyo 2018 Oct;64(10):403-407

The Department of Pathology, Osaka Rosai Hospital.

We report a case of renal pelvic cancer found after left renal trauma. A 63-year-old man was admitted to our hospital because of gross hematuria after he had fallen down the stairs two days earlier. He had asymptomatic severe anemia (Hb : 3. Read More

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October 2018

Unresolved Splenomegaly in Recently Resettled Congolese Refugees - Multiple States, 2015-2018.

MMWR Morb Mortal Wkly Rep 2018 12 14;67(49):1358-1362. Epub 2018 Dec 14.

In 2014, panel physicians from the International Organization for Migration (IOM), who conduct Department of State-required predeparture examinations for U.S.-bound refugees at resettlement sites in Uganda, noticed an unusually high number of Congolese refugees with enlarged spleens, or splenomegaly. Read More

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December 2018

Immune-mediated hemolytic anemia and thrombocytopenia in clonal B-cell disorders: a review.

Clin Adv Hematol Oncol 2018 Oct;16(10):670-676

Mayo Clinic, Rochester, Minnesota.

Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia purpura (ITP) have been associated with B-cell lymphoproliferative disorders. Here, we review the epidemiology, pathogenesis, diagnosis, and treatment of these autoimmune disorders, specifically in the setting of B-cell malignancies. AIHA and ITP are classically associated with chronic lymphocytic leukemia (CLL) but have also been reported in plasmacytic and lymphoproliferative disorders. Read More

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October 2018

New paradigms and therapies for iron replacement in iron deficiency anemia.

Authors:
Michael Auerbach

Clin Adv Hematol Oncol 2018 Nov;16(11):712-715

Auerbach Hematology and Oncology, Baltimore, Maryland, Georgetown University School of Medicine, Washington, DC.

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November 2018

Risk of postoperative morbidity in patients having bowel resection for colonic Crohn's disease.

Tech Coloproctol 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Ålborg University Hospital, Ålborg, Denmark.

Background: The aim of the present multicenter study was to analyze the incidence and risk factors associated with postoperative morbidity in patients who had colorectal resection for colonic Crohn's disease.

Methods: Consecutive patients undergoing colorectal resection for colonic Crohn's disease at seven surgical units in 1992-2017 were included. Exclusion criteria were: proctectomy for perianal disease, surgery for cancer, previous colectomies, surgery before 1998. Read More

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December 2018

Is there a relationship between restless legs syndrome and medical problems in pregnant women? A cross-sectional study in Iran.

Acta Neurol Belg 2018 Dec 12. Epub 2018 Dec 12.

Midwifery Department, Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

This study aimed to assess the relationship between RLS and medical problems among pregnant women. In this study, 700 pregnant women were recruited. A socio-demographic questionnaire and the International Restless Legs Questionnaire were used to gather information. Read More

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December 2018
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