21,792 results match your criteria Anemia Acute


Serum Biomarkers for Early Diagnosis of Chinese X-CGD Children: Case Reports and a Literature Review.

Curr Med Sci 2019 Apr 23;39(2):343-348. Epub 2019 Apr 23.

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Since X-linked chronic granulomatosis disease (X-CGD) exhibits no specific clinical symptoms at an early stage, early diagnosis is difficult and depends predominantly on neonatal screening. Therefore, the aim of this study was to explore routine biomarkers for X-CGD in children and provide clues for early diagnosis. The cases of 10 children with X-CGD diagnosed at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from 2013 to 2016 and 122 Chinese children with X-CGD reported in the literature were summarized. Read More

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http://dx.doi.org/10.1007/s11596-019-2041-3DOI Listing
April 2019
2 Reads

Role of Procalcitonin as a Predictor of Clinical Outcome in Acute Diabetic Foot Infections: A Prospective Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):122-127

Department of Endocrinology and Podiatry, Amrita Institute of Medical Sciences, Kochi, Kerala, India.

Background: Prediction of outcome in diabetic foot infection (DFI) remains difficult due to lack of active signs of infection, and apparently normal white blood cell (WBC) count. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have been studied previously in this regard and were not useful. Hence, we evaluated procalcitonin (PCT) as a prognostic marker in this study. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_525_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446684PMC

Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild Dried (Mont.) Mushroom in Rats.

Toxicol Res 2019 Apr 15;35(2):181-190. Epub 2019 Apr 15.

Department of Biochemistry, Abia State University, Abia State, Nigeria.

(Mont.) is an edible wild mushroom with tough fruiting body that belongs to the family Polyporaceae. It is used in ethnomedicine for the treatment of ulcer, anaemia, cough and fever. Read More

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http://www.toxicolres.org/journal/view.html?doi=10.5487/TR.2
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http://dx.doi.org/10.5487/TR.2019.35.2.181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467362PMC
April 2019
1 Read

Loxoscelism: Cutaneous and Hematologic Manifestations.

Adv Hematol 2019 20;2019:4091278. Epub 2019 Mar 20.

Department of Hematology and Oncology, West Cancer Clinic, 7945 Wolf River Blvd, Germantown, TN 38138, USA.

Background: Brown recluse spider (BRS) envenomation can lead to significant morbidity through severe local reaction and systemic illness including acute hemolytic anemia, rhabdomyolysis, disseminated intravascular coagulopathy (DIC), and even death. We aim to describe the clinical features and the roles of antibiotics and steroids in the treatment of loxoscelism.

Methods: We retrospectively identified nine patients (pts) at our institution who were admitted with moderate to severe loxoscelism. Read More

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http://dx.doi.org/10.1155/2019/4091278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446102PMC

The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology.

Background: Juvenile systemic lupus erythematosus (JSLE) and adult SLE (ASLE) patients present with different clinical manifestations, but it is unknown if there are differences in their antinuclear autoantibody (ANA) profiles or if staining patterns are associated with specific autoantibodies and clinical manifestations.

Objective: To determine whether distinct types and numbers of ANA-staining patterns are associated with specific autoantibodies and clinical manifestations in JSLE and ASLE patients.

Methods: A retrospective study was performed in Thai children (n = 146) and adults (n = 180) diagnosed with SLE using the Systemic Lupus International Collaborating Clinics classification criteria. Read More

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http://dx.doi.org/10.12932/AP-211218-0465DOI Listing

Plasma transfusion combined with chelating therapy alleviates fulminant Wilson's disease with a single Arg778Leu heterozygote mutation.

Ann Hepatol 2019 Apr 12. Epub 2019 Apr 12.

Institute of Hepatology, The Third People's Hospital of Changzhou, Changzhou, Jiangsu 213000, China; Department of Liver Diseases, The Third People's Hospital of Changzhou, Changzhou, Jiangsu 213000, China. Electronic address:

Wilson's disease (WD), resulting from homozygote and compound heterozygote mutations in ATB7B, is an autosomal recessive disease. WD associated acute liver failure (ALF) is fatal, and a revised Wilson's disease prognostic index (RWPI) >11 is a reliable indication of liver transplantation (LT) or artificial liver support (ALS). We described a WD patient who initially presented with ALF and severe hemolytic anemia. Read More

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http://dx.doi.org/10.1016/j.aohep.2018.07.001DOI Listing

Atypical Hemolytic Uremic Syndrome Presenting as Acute Heart Failure-A Rare Presentation: Diagnosis Supported by Skin Biopsy.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619842905

2 Westchester Medical Center, Valhalla, NY, USA.

Atypical hemolytic uremic syndrome (aHUS) is a rare disorder of uncontrolled complement activation that manifests classically as anemia, thrombocytopenia, and renal failure, although extrarenal manifestations are observed in 20% of the patient most of which involving central nervous system, with relatively rare involvement of the heart. In this article, we report the case of a 24-year-old male with no history of heart disease presenting with acute systolic heart failure along with microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Given his presentation of thrombotic microangiopathy (TMA), along with laboratory results significant for low haptoglobin, platelets, hemoglobin, C3, C4, CH50, and normal ADAMTS13 levels, with no diarrhea and negative STEC polymerase chain reaction in stool, aHUS diagnosis was established with strong clinical suspicion, and immediate initiation of treatment was advised. Read More

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http://dx.doi.org/10.1177/2324709619842905DOI Listing

Transfusion Ethics in a Pediatric Jehovah's Witness Trauma Patient: Simulation Case.

MedEdPORTAL 2016 Sep 1;12:10450. Epub 2016 Sep 1.

Assistant Professor of Anesthesiology, Loma Linda University School of Medicine.

Introduction: Current ethical practice allows for adult patients with decision-making capacity to refuse blood transfusion, even at the cost of high morbidity or mortality. However, for an adult patient who is of the Jehovah's Witness faith, an unwanted blood transfusion confers a psychospiritual cost to the patient and a financial cost to health care entities. The ethical boundaries are increasingly ambiguous with minors who are members of the Jehovah's Witness faith. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464417PMC
September 2016

Dynamic iron status after acute heart failure.

Arch Cardiovasc Dis 2019 Apr 18. Epub 2019 Apr 18.

Heart Failure and Valvular Heart Disease Unit, Mediterranean University Cardio-Oncology (MEDI-CO) Centre, Department of Cardiology, Aix-Marseille University, hôpital Nord, AP-HM, chemin des Bourrely, 13015 Marseille, France; Inserm 1263, INRA, centre de recherche cardiovasculaire et nutrition (C2VN), Aix-Marseille University, 13385 Marseille, France. Electronic address:

Background: Iron deficiency (ID) is common in heart failure (HF), and is associated with unfavourable clinical outcomes. Although it is recommended to screen for ID in HF, there is no clear consensus on the optimal timing of its assessment.

Aim: To analyse changes in iron status during a short-term follow-up in patients admitted for acute HF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18752136193007
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http://dx.doi.org/10.1016/j.acvd.2019.02.002DOI Listing
April 2019
1 Read

Hunter syndrome with persistent thrombocytopenia.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Pediatrics, APC, PGIMER, Chandigarh, India.

A case of Hunter syndrome, 6½-year-old boy presented with persistent thrombocytopenia and bleeding diathesis. However, cytopenia is not a usual presentation in patients with mucopolysaccharidosis II. After ruling out other causes of severe thrombocytopenia, a clinical possibility of chronic Epstein-Barr virus (EBV) infection was considered. Read More

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http://dx.doi.org/10.1136/bcr-2018-226518DOI Listing

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

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April 2019
2 Reads

Assessment of a Geriatric Hip Fracture Program: Analysis of Harmful Adverse Events Using the Global Trigger Tool.

J Bone Joint Surg Am 2019 Apr;101(8):704-709

Department of Orthopedics, Brown University, Providence, Rhode Island.

Background: The purpose of this study was to assess the impact of adding a geriatric comanagement program to the care of geriatric patients with a hip fracture at our hospital. The Institute for Healthcare Improvement (IHI) Global Trigger Tool (GTT) was used to follow the frequency and severity of adverse events occurring in hospitalized patients and to examine the effectiveness of a comanagement program (the Geriatric Hip Fracture Program [GHFP]).

Methods: Data were collected for patients treated for a hip fracture from 2010 to 2014, which was 1 year prior to (October 2010 to September 2011) and 2 years after the implementation of the GHFP, and were grouped into 3-month intervals for analysis. Read More

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http://dx.doi.org/10.2106/JBJS.18.00376DOI Listing
April 2019
1 Read

Presumed immune-mediated haemolytic anaemia associated with pregnancy in a cat.

JFMS Open Rep 2019 Jan-Jun;5(1):2055116919841689. Epub 2019 Apr 4.

School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Case Summary: A 7-year-old female entire Birman presented with acute-onset haemorrhagic vulvar discharge. Moderate, normocytic, normochromic, non-/pre-regenerative anaemia, along with a moderate mature neutrophilia, were seen on haematology. Saline test for agglutination was positive. Read More

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http://dx.doi.org/10.1177/2055116919841689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449813PMC
April 2019
1 Read

Acute adrenal haemorrhage in two cats with aldosterone-secreting adenocarcinomas.

JFMS Open Rep 2019 Jan-Jun;5(1):2055116919840828. Epub 2019 Apr 3.

Valentine Charlton Cat Centre, University Veterinary Teaching Hospital, Sydney School of Veterinary Science, Faculty of Science, University of Sydney, NSW, Australia.

Case Summary: Two 13-year-old domestic shorthair cats were diagnosed with unilateral right adrenocortical carcinomas (ACCs) and primary hyperaldosteronism (PHA). Both had polyuria, polydipsia and weight loss, and developed severe anaemia from an episode of acute adrenal haemorrhage. In one case, this occurred during hospitalisation and treatment of severe muscle weakness with cervical ventroflexion, while the other cat had acute collapse at home. Read More

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http://journals.sagepub.com/doi/10.1177/2055116919840828
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http://dx.doi.org/10.1177/2055116919840828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449812PMC
April 2019
3 Reads

Rh phenotype caused by a novel RHAG mutation, c.945+1G>A, in the Japanese population.

Transfusion 2019 Apr 16. Epub 2019 Apr 16.

Department of Transfusion Medicine, Cell Therapy and Regenerative Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.

Background: The Rh complex contributes to cell membrane structural integrity of erythrocytes. Rh syndrome is characterized by the absence of the Rh antigen on the erythrocyte membrane, resulting in chronic hemolytic anemia. We recently came across 3 Rh phenotype probands within two families with the same novel RHAG mutation in the Japanese population. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.15312
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http://dx.doi.org/10.1111/trf.15312DOI Listing
April 2019
2 Reads

Kidney recovery in patients discharged to an acute rehabilitation facility with acute kidney injury requiring hemodialysis
.

Clin Nephrol 2019 Apr 16. Epub 2019 Apr 16.

Background: Patients with acute kidney injury requiring renal replacement therapy (AKI-RRT) are at risk of adverse outcomes. Little is known about the incidence of AKI-RRT recovery following hospital discharge. We examine AKI-RRT recovery in hospital survivors discharged to a long-term acute care hospital (LTACH) with need of hemodialysis (HD) for AKI. Read More

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http://dx.doi.org/10.5414/CN109743DOI Listing
April 2019
1 Read

Impact of Preoperative Anemia on Postoperative Kidney Function Following Laparoscopic Bariatric Surgery.

Obes Surg 2019 Apr 13. Epub 2019 Apr 13.

Weight Loss and Health Management Center, E-Da Dachang Hospital, No. 305, Dachang 1st Rd., Sanmin Dist., Kaohsiung City, 807, Taiwan.

Background: Preoperative anemia is a risk factor for acute kidney failure after high-risk surgeries. We assessed the impact of preoperative anemia on kidney function in an obese Asian population after laparoscopic bariatric surgery.

Methods: Patient characteristics, comorbidities, type of surgery, perioperative profiles, eGFR, and micronutrition were retrospectively reviewed in 341 patients with obesity undergoing bariatric surgery. Read More

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http://dx.doi.org/10.1007/s11695-019-03869-6DOI Listing
April 2019
4 Reads

Fluid Intake But Not Fluid Balance Is Associated With Poor Outcome in Nontraumatic Subarachnoid Hemorrhage Patients.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Neurological Intensive Care Unit, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Objectives: Optimal fluid management is important in patients with acute brain injury, including subarachnoid hemorrhage. We aimed to examine the relationship between daily fluid intake and fluid balance with hospital complications and functional outcome.

Design: Retrospective observational cohort study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003775DOI Listing
April 2019
1 Read

[HELLP syndrome and hemolytic uremic syndrome during pregnancy: two disease entities, same causation. Case report and literature review].

G Ital Nefrol 2019 Apr;36(2)

Centro per la Cura e lo Studio della Sindrome Emolitico-Uremica. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano.

Thrombotic microangiopathies (TMA) are a group of diseases that can complicate pregnancy and threaten the lives of both the mother and the fetus. Several conditions can lead to TMA, including thrombotic thrombocytopenic purpura (TTP), HELLP syndrome and hemolytic uremic syndrome (HUS). We describe the case of a 39-year-old woman who presented a HELLP syndrome in the immediate postpartum period. Read More

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April 2019
3 Reads

Non-specific chest pain and subsequent serious cardiovascular readmissions.

Int J Cardiol 2019 Apr 2. Epub 2019 Apr 2.

Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, UK; Royal Stoke University Hospital, Stoke-on-Trent, UK. Electronic address:

Background: The rates of readmission for serious cardiovascular events among patients admitted with a diagnosis of non-specific chest pain are unknown.

Methods: A national retrospective cohort study in the United States was undertaken to evaluate the rates, trends and predictors of readmission for serious cardiovascular events (acute coronary syndrome (ACS), pulmonary embolism (PE) and aortic dissection (AD)) after an inpatient episode with a primary diagnosis of non-specific chest pain.

Results: Among 1,172,430 patients with an index diagnosis of non-specific chest pain between 2010 and 2014, 2. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.04.001DOI Listing
April 2019
2 Reads

[Endoscopy, angiography, surgery: diagnostic and therapeutic algorithms for diverticular bleeding].

Authors:
W Schwenk

Chirurg 2019 Apr 11. Epub 2019 Apr 11.

Klinik für Allgemein‑, Viszeral- und Gefäßchirurgie, Städtisches Klinikum Solingen gGmbH, Gotenstraße 1, 42653, Solingen, Deutschland.

Diverticular bleeding is a complication of diverticular disease but in contrast to diverticulitis, publications concerning diverticular bleeding are less common. Diverticular bleeding is the cause of approximately 20-50% of cases of lower gastrointestinal bleeding and in rare cases can be life-threatening. The main symptom of diverticular hemorrhage is painless hematochezia and the German guidelines recommend that further diagnostics of suspected diverticular bleeding should be performed in hospital. Read More

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http://link.springer.com/10.1007/s00104-019-0950-0
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http://dx.doi.org/10.1007/s00104-019-0950-0DOI Listing
April 2019
5 Reads

Recreational 'mud fever': induced diffuse alveolar hemorrhage and severe acute respiratory distress syndrome in a U.S. Navy seaman following 'mud-run' in Hawaii.

IDCases 2019 23;15:e00529. Epub 2019 Mar 23.

University of Maryland School of Medicine, Baltimore, MD, United States.

A 23-year-old man with a viral-like prodrome developed sudden severe dyspnea and was found to have renal failure, anemia, shock, and diffuse alveolar hemorrhage with acute respiratory distress syndrome, requiring emergent endotracheal intubation and extracorporeal membrane oxygenation (ECMO). Travel and exposure history from peripheral sources revealed that the patient had participated in a 'mud-run' in Hawaii two weeks prior to symptom onset. The patient was subsequently diagnosed with leptospirosis and treated with ceftriaxone and doxycycline. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441746PMC
March 2019
3 Reads

Association of genetic polymorphisms with acute kidney injury after cardiac surgery in a Southeast Asian population.

PLoS One 2019 11;14(4):e0213997. Epub 2019 Apr 11.

Department of Anaesthesiology, Singapore General Hospital, Academia, Level 5, Singapore.

Introduction: Genetic polymorphisms are important in explaining the wide interpatient variability that exists in the development of acute kidney injury (AKI) post cardiac surgery. We hypothesised that polymorphisms in 4 candidate genes, namely angiotensin-converting enzyme (ACE), apolipoprotein-E (ApoE), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α) are associated with AKI.

Methods: 870 patients who underwent cardiac surgery in Singapore were analysed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213997PLOS
April 2019
1 Read

Human parvovirus B19 in solid organ transplantation: Guidelines from the American society of transplantation infectious diseases community of practice.

Clin Transplant 2019 Apr 11:e13535. Epub 2019 Apr 11.

Department of Pediatrics, Infectious Diseases and Host Defense, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.

Clinical manifestations of human parvovirus B19 infection can vary widely and may be atypical in solid organ transplant (SOT) recipients. However, disease is apparent when there is destruction of erythrocyte progenitor cells leading to severe acute or chronic anemia with lack of an appropriate reticulocyte response in the setting of active parvovirus B19 infection. Serology may not reliably establish the diagnosis. Read More

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http://dx.doi.org/10.1111/ctr.13535DOI Listing
April 2019
1 Read

A nationwide comparative analysis of medical complications in fibromyalgia patients following total knee arthroplasty.

Ann Transl Med 2019 Feb;7(4):64

Department of Orthopaedic Surgery, Lenox Hill Hospital, Northwell Health, New York, NY, USA.

Background: Fibromyalgia is a disease primarily characterized by chronic widespread pain and associated symptoms of fatigue, mild cognitive impairment, and sleep disturbance. The condition affects 1% to 6% of the general population in the United States and is more commonly diagnosed in women (2:1 ratio). There is evidence to suggest that fibromyalgia patients may be more at risk of postoperative complications. Read More

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http://atm.amegroups.com/article/view/23335/22774
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http://dx.doi.org/10.21037/atm.2018.12.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409227PMC
February 2019
8 Reads

Osteomyelitis Caused by Carbapenemase-Producing Klebsiella Pneumoniae: A Diagnosis to Consider in Patients with Hematologic Malignancies and Stem Cell Transplant Recipients.

Am J Case Rep 2019 Apr 9;20:482-488. Epub 2019 Apr 9.

Department of Hematology and Bone Marrow Transplantation, Hospital de Santa Maria, CHLN - EPE, Lisboa, Portugal.

BACKGROUND Osteomyelitis (OM) due to carbapenemase-producing Klebsiella pneumoniae (CPKp) is a very rare but severe condition, particularly among patients with hematologic malignancies and stem cell transplant recipients, who are especially at risk of developing nosocomial infections caused by this bacterium. CASE REPORT We describe 2 cases of acute and chronic OM by CPKp in adults with hematologic disorders. Patient 1, with acute lymphoblastic leukemia, developed bacteremia due to multidrug CPKp after induction chemotherapy. Read More

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http://dx.doi.org/10.12659/AJCR.909965DOI Listing
April 2019
1 Read

[THE FEATURES OF THE COURSE OF INFECTIOUS MONONUKLEOSIS OF DIFFERENT ETIOLOGY IN CHILDREN].

Georgian Med News 2019 Feb(287):51-56

Odessa National Medical University, Ukraine.

Aim - to study the effect of different pathogens (EBV, CMV, HHV-6, and MIXT) on the severity of clinical-paraclinical manifestations of infectious mononucleosis in children. The clinical and laboratory study performed for 410 children aged from 10 months up to 12 years with infectious mononucleosis. The association of herpes viruses, mainly EBV, CMV and HHV type 6, takes part in the formation of the clinical picture of IM in (52,9%) of cases. Read More

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February 2019
3 Reads

Causes of hospitalization in sickle cell diseased children in western region of Saudi Arabia. A single center study.

Saudi Med J 2019 Apr;40(4):401-404

Pediatric Department, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia. E-mail.

Objectives: To highlight the causes of hospitalization among sickle cell diseased (SCD) children in Al-Madinah Al-Munawarah, Saudi Arabia.

Methods: A retrospective study conducted at the Maternity and Children's Hospital, Al-Madinah Al-Munawarah, Saudi Arabia. A data of 739 SCD children admitted to the hematology/oncology unit between October 2010 and September 2015 were collected. Read More

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http://dx.doi.org/10.15537/smj.2019.4.24049DOI Listing
April 2019
1 Read

Scrub typhus infection, not a benign disease: an experience from a tertiary care center in Northern India.

Med Pharm Rep 2019 Jan 15;92(1):36-42. Epub 2019 Jan 15.

Internal Medicine Department, Pt. BD Sharma PGIMS, Rohtak, India.

Introduction: Scrub typhus is an acute febrile illness caused by . It is characterised by fever, rash, myalgia and diffuse lymphadenopathy. Most common complications are sepsis, shock, acute respiratory distress syndrome (ARDS), hepatitis, pre renal azotemia and multi organ dysfunction syndrome (MODS). Read More

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http://dx.doi.org/10.15386/cjmed-1088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448495PMC
January 2019
5 Reads

Prediction of Discharge Destination Following Major Hepatectomy.

HPB (Oxford) 2019 Apr 4. Epub 2019 Apr 4.

Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Surgery, VA Boston Healthcare System, West Roxbury, MA, USA.

Background: Anatomic hepatectomies can be associated with complicated post-operative recoveries, often with discharge to post-acute care facilities. This study identifies preoperative and intraoperative factors associated with increased risk for non-home discharge destination after major hepatectomy.

Methods: Patients undergoing major hepatectomy were identified in the NSQIP Targeted Hepatectomy Dataset (2014-2016). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.354DOI Listing
April 2019
1 Read

The v-DECAF score can predict 90-day all-cause mortality in patients with COPD exacerbation requiring invasive mechanical ventilation.

Clin Respir J 2019 Apr 6. Epub 2019 Apr 6.

Department of Emergency and Critical Care Medicine Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, China.

Introduction: The DECAF score is a simple and effective tool for predicting mortality in patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (AECOPD); however, the DECAF score has not been validated in AECOPD patients requiring invasive mechanical ventilation (IMV). We devised the ventilator (v)-DECAF score, in which "anemia" replaces "acidaemia," for use in AECOPD patients requiring IMV. The objective of this study was to compare the predictive efficacy of the v-DECAF score and the DECAF score. Read More

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http://dx.doi.org/10.1111/crj.13028DOI Listing
April 2019
2 Reads

Stroke Recurrence in Nigerian Children With Sickle Cell Disease: Evidence for a Secondary Stroke Prevention Trial.

Pediatr Neurol 2019 Jan 17. Epub 2019 Jan 17.

Department of Hematology and Blood Transfusion, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria. Electronic address:

Background: To improve the quality of care for children with sickle cell anemia in Kano, Nigeria, we initiated a standard care protocol in 2014 to manage children with strokes at Aminu Kano Teaching Hospital.

Methods: The standard care protocol requires that children with acute strokes be treated with hydroxyurea at a fixed dose of 20 mg/kg/day within two months of the stroke.

Results: Twenty-nine children with sickle cell anemia and initial stroke were identified based on clinical World Health Organization criteria from 2014 to 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183089
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http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.008DOI Listing
January 2019
4 Reads

Morbidity in a longitudinal cohort of children residing in villages randomized to 6 monthly treatment with azithromycin versus placebo.

Clin Infect Dis 2019 Apr 5. Epub 2019 Apr 5.

Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD, USA.

Background: The mechanisms underlying the finding of reduced child mortality in communities with biannual treatment with azithromycin remain unclear. We determined if there was a difference in morbidity in a cohort of children ages 1 to 36 months, residing in communities randomized to biannual treatment of pre-school age children with azithromycin or placebo.

Methods: 30 villages in Kilosa Tanzania were randomly assigned to receive biannual treatment of all children ages 1 to 59 months with either azithromycin (20/mg/kg single dose) or placebo. Read More

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http://dx.doi.org/10.1093/cid/ciz269DOI Listing
April 2019
3 Reads

Acute myocardial infarction and renal dysfunction due to chronic extreme anemia (hemoglobin 2.5 g/dL) in immune thrombocytopenia.

Proc (Bayl Univ Med Cent) 2018 Oct 23;31(4):508-510. Epub 2018 Oct 23.

Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at HoustonHoustonTexas.

Immune thrombocytopenic purpura (ITP) is an acquired thrombocytopenia where autoantibodies are generated against platelet antigens. Primary ITP is often idiopathic, whereas secondary ITP has many potential causes, including drug induced, infection related (human immunodeficiency virus, hepatitis C), leukemias, or autoimmune such as systemic lupus erythematosus. ITP is a common cause of thrombocytopenia in asymptomatic individuals, where evidence of bleeding may be minor or absent. Read More

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http://dx.doi.org/10.1080/08998280.2018.1499317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413974PMC
October 2018
2 Reads

Sickle Cell Disease and Stroke.

Pediatr Neurol 2019 Feb 27. Epub 2019 Feb 27.

Developmental Neurosciences Section and Biomedical Research Unit, Clinical and Experimental Sciences, University of Southampton, UCL Great Ormond Street Institute of Child Health, London, UK. Electronic address:

Cerebral infarction is a common complication of sickle cell disease and may manifest as overt stroke or cognitive impairment associated with "silent" cerebral infarction on magnetic resonance imaging. Vasculopathy may be diagnosed on transcranial Doppler or magnetic resonance angiography. The risk factors in sickle cell disease for cognitive impairment, overt ischemic stroke, silent cerebral infarction, overt hemorrhagic stroke, and vasculopathy defined by transcranial Doppler or magnetic resonance angiography overlap, with severe acute and chronic anemia, acute chest crisis, reticulocytosis, and low oxygen saturation reported with the majority. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183130
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http://dx.doi.org/10.1016/j.pediatrneurol.2019.02.018DOI Listing
February 2019
2 Reads

Protocol and baseline data for a prospective open-label explorative randomized single-center comparative study to determine the effects of various intravenous iron preparations on markers of oxidative stress and kidney injury in chronic kidney disease (IRON-CKD).

Trials 2019 Apr 4;20(1):194. Epub 2019 Apr 4.

Hull University Teaching Hospitals NHS Trust and Hull York Medical School, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ, UK.

Background: Intravenous (IV) iron is frequently used to treat iron deficiency/anemia in patients who are unable to tolerate oral iron or the oral iron is not sufficient toreplete iron requirements. However, safety concerns regarding the potential increase in oxidative stress and other adverse effects persist and it remains unclear whether all iron preparations are equivalent. Indeed, the comparative risk of adverse events with IV iron preparations has not been extensively assessed. Read More

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http://dx.doi.org/10.1186/s13063-019-3291-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449958PMC
April 2019
3 Reads

Severe Anemia Is Associated with Intestinal Injury in Preterm Neonates.

Am J Perinatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Neonatalogy, Yildirim Beyazit Universty Faculty of Medicine, Ankara, Turkey.

Background:  A temporal relationship has been reported between necrotizing enterocolitis, anemia, and red blood cell transfusion (RBCT) in preterm neonates. However, the mechanism underlying this association is not clearly defined. Intestinal (I-) and liver (L-) fatty acid binding proteins (FABPs) have been proposed as plasma markers for the detection of acute intestinal injury. Read More

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http://dx.doi.org/10.1055/s-0039-1683982DOI Listing
April 2019
4 Reads

Treatment-Related Complications of Systemic Therapy and Radiotherapy.

JAMA Oncol 2019 Apr 4. Epub 2019 Apr 4.

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut.

Importance: Systemic therapy and radiotherapy can be associated with acute complications that may require emergent care. However, there are limited data characterizing complications and the financial burden of cancer therapy that are treated in emergency departments (EDs) in the United States.

Objectives: To estimate the incidence of treatment-related complications of systemic therapy or radiotherapy, examine factors associated with inpatient admission, and investigate the overall financial burden. Read More

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2019.0086DOI Listing
April 2019
5 Reads

Early chemotherapy de-escalation strategy in advanced-stage Hodgkin lymphoma patients with negative positron emission tomography scan after two escalated BEACOPP cycles.

Pol Arch Intern Med 2019 Apr 4. Epub 2019 Apr 4.

INTRODUCTION Escalated BEACOPP (escBEACOPP: bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) significantly improves overall response rates (ORR) and prolongs progression-free survival (PFS) in advanced-stage Hodgkin lymphoma (HL) patients. However, 6-8 cycles of escBEACOPP are associated with increased acute toxicity and late complications. OBJECTIVES We aimed to determine the role of early positron emission tomography-computed tomography (PET-CT) response assessment in the de-escalation strategy. Read More

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http://dx.doi.org/10.20452/pamw.14786DOI Listing
April 2019
2 Reads

Case report of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE): a rare disease may contribute to endoscopy-capsule retention in the small intestine.

BMC Gastroenterol 2019 Apr 3;19(1):49. Epub 2019 Apr 3.

Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Ren-Ji Hospital, Shanghai Jiao-Tong University School of Medicine, 145 Middle Shandong Road, Shanghai, 200001, China.

Background: CMUSE is a rare disease whose diagnosis remains difficult because the lesion is confined to the small bowel.

Case Presentation: Here, we present a case of 43-year-old female patient suffered chronic abdominal pain for 20 years, and finally diagnosed with CMUSE. Capsule endoscopy was performed when general endoscopic investigation failed to find the lesion, but the capsule was stranded in the small intestine. Read More

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http://dx.doi.org/10.1186/s12876-019-0962-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448319PMC
April 2019
4 Reads

Is Endurance Exercise Safe? The Myth of Pheidippides.

South Med J 2019 Apr;112(4):210-214

From the Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock.

With the increase in participation in endurance events in the general population, patient concern may arise as to whether endurance exercise is safe. Acute but not chronic increases in blood urea nitrogen, creatinine, and urine albumin occur in endurance exercise. Iron-deficiency anemia may be observed in female athletes. Read More

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http://dx.doi.org/10.14423/SMJ.0000000000000961DOI Listing
April 2019
2 Reads

Elective lumbar fusion in the United States: national trends in inpatient complications and cost from 2002-2014.

J Neurosurg Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Orthopedic Surgery, Boston Medical Center, Boston, MA, USA -

Background: Elective fusions for degenerative spine disease have increased over the past two decades in the United States, with variability in complications and hospital costs. The additional service costs associated with adverse perioperative events remain unknown. Our objective is to improve understanding of trends in safety and cost of elective lumbar fusions on a national scale. Read More

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http://dx.doi.org/10.23736/S0390-5616.19.04647-2DOI Listing
April 2019
3 Reads
0.780 Impact Factor

A Case of Acquired Haemophilia A in a Patient with Chronic Myelomonocytic Leukaemia.

Case Rep Hematol 2019 27;2019:8612031. Epub 2019 Feb 27.

Department of Hematology and Oncology, Kita-Harima Medical Center, Hyogo, Japan.

A 67-year-old male, with a known diagnosis of myelodysplastic syndromes with multilineage dysplasia (MDS-MLD) was admitted to our hospital with a primary complaint of subcutaneous bleeding in his left thigh. Laboratory data showed anaemia and prolongation of activated partial thromboplastin time (85.8 s, normal range 24-39 s) without thrombocytopenia. Read More

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http://dx.doi.org/10.1155/2019/8612031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415290PMC
February 2019
4 Reads

Severe maternal morbidity (near-miss) and its correlates in the world's newest nation: South Sudan.

Int J Womens Health 2019 19;11:177-190. Epub 2019 Mar 19.

Department of Obstetrics and Gynecology, Juba Teaching Hospital, Juba, South Sudan.

Background: This study investigates the frequency of near-miss events and compares correlates in the world's newest nation.

Methods: A cross-sectional study was carried out to audit near-miss events and their causes. A total of 1,041 mothers were sampled. Read More

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http://dx.doi.org/10.2147/IJWH.S160022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429996PMC
March 2019
5 Reads

Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention.

Am J Kidney Dis 2019 Mar 28. Epub 2019 Mar 28.

Singapore Eye Research Institute, Singapore National Eye Centre; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School. Electronic address:

Eyes and kidneys have numerous structural, developmental, physiologic, and pathogenic pathways in common, suggesting that many kidney and eye diseases may be interlinked. Studies suggest that the prevalence of eye diseases and vision impairment are higher among persons with end-stage kidney disease and earlier stages of chronic kidney disease (CKD) than in those without. Ocular morbidity in persons with CKD and end-stage kidney disease may be due to the following risk factors: (1) underlying conditions and risk factors for CKD such as diabetes or hypertension, (2) metabolic disorders associated with CKD, (3) uremia and anemia, and (4) CKD treatment. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.047DOI Listing
March 2019
5 Reads
5.900 Impact Factor

[Clinical features and risk factors of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation].

Zhonghua Xue Ye Xue Za Zhi 2019 Mar;40(3):187-190

Department of Hematology, PLA 960 Hospital, Jinan 250031, China.

To explore the relative risk factors, clinical intervention and prognosis of hemorrhagic cystitis (HC) in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT) . From January 1 2010 to May 31 2017, 425 patients with allo-HSCT received a retrospective analysis. ①Among the 425 patients, 262 were male and 163 were female. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.03.004DOI Listing
March 2019
1 Read

Uretero-iliac artery fistula: a challenge diagnosis for a life-threatening condition: monocentric experience and review of the literature.

Int Urol Nephrol 2019 Mar 30. Epub 2019 Mar 30.

Clinica Urologica, Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy.

Introduction: Uretero-iliac artery fistulae (UIAF) are the consequence of chronic inflammatory events that create a fibrous and poorly vascularized uretero-vascular adhesion. They often occur in patients with a history of surgery, pelvic radiotherapy, and chronic ureteral stenting. The presentation is usually massive gross hematuria with acute anemia unto to hemorrhagic shock, representing a life-threatening condition. Read More

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http://dx.doi.org/10.1007/s11255-019-02097-2DOI Listing
March 2019
2 Reads
1.293 Impact Factor

Pediatric Vaginal Leech Infestation with Severe Bleeding: A Case Report and Review Article.

J Pediatr Adolesc Gynecol 2019 Mar 27. Epub 2019 Mar 27.

Cutaneous leishmaniasis Research Center, Mashhad University Of Medical science, Mashhad, Iran.

Background: Vaginal leech infestation is a rare event with vaginal bleeding being its prominent sign. Few cases have been reported in young children.

Case: In this article, we present a case of vaginal leech infestation in a two-year-old girl who presented with significant vaginal bleeding that caused severe acute anemia, prompting transfusion. Read More

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http://dx.doi.org/10.1016/j.jpag.2019.03.007DOI Listing
March 2019
1 Read
1.812 Impact Factor

What's New in Cardiopulmonary Bypass.

Authors:
Eugene A Hessel

J Cardiothorac Vasc Anesth 2019 Jan 16. Epub 2019 Jan 16.

Department of Anesthesiology, College of Medicine, University of Kentucky, Lexington, KY. Electronic address:

This is a narrative review of recent articles (mainly published in 2017 and 2018) related to the conduct of cardiopulmonary bypass (CPB) that should be of interest to the cardiac anesthesiologist. Some of the topics covered include recent guidelines on temperature management, anticoagulation, perfusion practice, use of transesophageal echocardiography during CPB, optimal mean arterial pressure, vasoplegia, bleeding, perioperative anemia, post-cardiac surgery transfusion, acute kidney injury, delirium and cognitive decline, CPB during pregnancy, lung management, radial-to-femoral artery pressure gradients during CPB, prophylactic perioperative intra-aortic balloon pump, del Nido cardioplegia, antibiotic prophylaxis, and use of levosimendan in cardiac surgery. The review concludes with a perspective on the effect of these development on the practice of cardiac anesthesia. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.039DOI Listing
January 2019
11 Reads

Comparable Outcomes of First-Line Hematopoietic Stem Cell Transplantation from Unrelated and Matched Sibling Donors in Adult Patients with Aplastic Anemia: A Retrospective Single-Center Study.

Biol Blood Marrow Transplant 2019 Mar 26. Epub 2019 Mar 26.

Department of Hematology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China; Department of Hematology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address:

To explore the feasibility of upfront unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) in the treatment of adult aplastic anemia (AA), we conducted a retrospective, single-center study and compared the outcomes of adult patients who underwent first-line URD HSCT or matched sibling donor (MSD) HSCT between August 2012 and June 2018. In all, 23 URD HSCT recipients had an increased cumulative incidence of grade II acute graft-versus-host disease (aGVHD) (21.7% versus 3. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.03.020DOI Listing
March 2019
1 Read