21,631 results match your criteria Anemia Acute


Dietary Iron Deficiency Impaired Peripheral Immunity but Did Not Alter Brain Microglia in PRRSV-Infected Neonatal Piglets.

Front Immunol 2018 4;9:3150. Epub 2019 Feb 4.

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.

During the postnatal period the developing brain is vulnerable to insults including nutrient insufficiency and infection that may lead to disrupted development and cognitive dysfunction. Since iron deficiency (ID) often presents with immunodeficiency, the objective of this study was to investigate peripheral viremia and inflammation as well as brain microglial phenotype and function when ID and respiratory infection occur simultaneously in a neonatal piglet model. On postnatal day 2 (PD 2) male and female piglets were assigned to one of four treatments and fed either control or ID milk replacer. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369153PMC
February 2019

Impact of Co-Morbidities on the Cost of Care in Primary Elective Joint Arthroplasty.

J Arthroplasty 2019 Jan 24. Epub 2019 Jan 24.

Department of Orthopaedic Surgery at Brigham and Women's Hospital, Boston, MA.

Background: The Comprehensive Care for Joint Replacement model is the newest iteration of the bundled payment methodology introduced by the Centers for Medicare and Medicaid Services. Comprehensive Care for Joint Replacement model, while incentivizing providers to deliver care at a lower cost, does not incorporate any patient-level risk stratification. Our study evaluated the impact of specific medical co-morbidities on the cost of care in total joint arthroplasty (TJA) patients. Read More

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http://dx.doi.org/10.1016/j.arth.2019.01.038DOI Listing
January 2019

Predictable and Unusual Adverse Effects of Immunosuppression in Pediatric Liver Transplant Patients.

Exp Clin Transplant 2019 Jan;17(Suppl 1):230-233

From the Department of Pediatric Gastroenterology,Gazi University Faculty of Medicine, Ankara, Turkey.

Objectives: Our aim was to determine potentially adverse effects of immunosuppressive protocols after liver transplantation in children.

Materials And Methods: The medical records of 60 children who underwent liver transplant retrospectively analyzed. Corticosteroid, tacrolimus, and mycophenolate mofetil were the primary immunosuppressive agents used in our center. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P81DOI Listing
January 2019

Late Presentation of Transfusion-related Acute Lung Injury in the Emergency Department.

Clin Pract Cases Emerg Med 2019 Feb 7;3(1):33-35. Epub 2019 Jan 7.

San Antonio Uniformed Services Health Education Consortium, Department of Emergency Medicine, San Antonio, Texas.

Transfusion-related acute lung injury (TRALI) is a complication of blood product transfusion characterized by respiratory distress with bilateral lung infiltrates and non-cardiogenic pulmonary edema developing within six hours of transfusion. TRALI is believed to result from an immunological response to transfused blood products. TRALI is a clinical diagnosis that requires the exclusion of other etiologies of pulmonary edema and acute lung injury. Read More

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http://dx.doi.org/10.5811/cpcem.2018.11.40592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366380PMC
February 2019

Effect of a novel supplementary porridge on the nutritional status of infants and young children diagnosed with moderate acute malnutrition in Uganda: a cluster randomised control trial.

J Hum Nutr Diet 2019 Feb 18. Epub 2019 Feb 18.

College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa.

Background: Moderate acute malnutrition (MAM) and anaemia are prevalent among infants and young children (IYC) in Uganda. A lack of consensus regarding the most effective strategy for managing MAM among IYC resulted in the present study comparing the effect of malted sorghum-based porridge (MSBP) (an active malt, extruded maize and soy sorghum supplementary porridge developed for the purpose of the present study) as an intervention versus an extruded maize and soy micronutrient fortified blend (CSB+) as a control and current standard care. Outcome measures were anthropometric status and haemoglobin levels. Read More

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http://dx.doi.org/10.1111/jhn.12635DOI Listing
February 2019

CT Attenuation of Acute Subdural Hematomas in Patients with Anemia.

J Neuroimaging 2019 Feb 16. Epub 2019 Feb 16.

Diagnostic Radiology Department, Lahey Hospital and Medical Center, Burlington, MA.

Background And Purpose: Isodense and hypodense acute subdural hematomas have been reported in the literature in anemic patients. The purpose of this study is to see if there is a statistically significant difference between the Hounsfield unit measurements of acute subdural hematomas in anemic and nonanemic patients.

Methods: A total of 109 patients were analyzed. Read More

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http://dx.doi.org/10.1111/jon.12608DOI Listing
February 2019

Corticosteroid Therapy for Indeterminate Pediatric Acute Liver Failure and Aplastic Anemia with Acute Hepatitis.

J Pediatr 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL.

Objective: To examine the characteristics and outcomes of a multicenter patient cohort with indeterminate pediatric acute liver failure (IND-PALF) and with aplastic anemia with acute hepatitis treated with corticosteroids.

Study Design: Retrospective study of patients age 1-17 years with IND-PALF and aplastic anemia with acute hepatitis who presented between 2009 and 2018 to 1 of 4 institutions and were treated with corticosteroids for presumed immune dysregulation.

Results: Of 28 patients with IND-PALF (median of 4. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.042DOI Listing
February 2019

Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data from the Veterans Aging Cohort Study.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana.

Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown.

Methods: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001981DOI Listing
February 2019

Post renal transplant anemia: severity, causes and their association with graft and patient survival.

BMC Nephrol 2019 Feb 13;20(1):51. Epub 2019 Feb 13.

Department of Nephrology and Hypertension, Rabin Medical Center, Petah Tikva, Israel.

Background: Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased mortality. However, the effect of the severity of anemia on this associations was not thoroughly evaluated. Read More

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http://dx.doi.org/10.1186/s12882-019-1244-yDOI Listing
February 2019
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Acute Anaemia: A Challenging Diagnosis.

Eur J Case Rep Intern Med 2018 27;5(9):000956. Epub 2018 Sep 27.

Internal Medicine Department, Hospital São Francisco Xavier, Lisbon, Portugal.

Acute anaemia is characterized by a reduction in the number of red blood cells, haemoglobin levels or haematocrit. By far the most common aetiology is haemorrhage, but in its absence other less frequent causes should be considered. The authors present the case of a 42-year-old man with a diagnosis of glucose-6-phosphate deficiency and progressing gastric signet ring cell carcinoma, who was admitted to the internal medicine department for symptomatic back pain control. Read More

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http://dx.doi.org/10.12890/2018_000956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346818PMC
September 2018
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A Reflection on the Use of Enoxaparin Based on Three Case Reports.

Eur J Case Rep Intern Med 2018 27;5(12):001000. Epub 2018 Dec 27.

Internal Medicine Department, Hospital São Francisco Xavier, Lisbon, Portugal.

Enoxaparin is indicated for the treatment or prevention of many clinical disorders including deep vein thromboembolism, atrial fibrillation and mechanical valve thrombosis. It is one of the most commonly prescribed drugs in hospitals. However, haemorrhagic complications can occur, particularly in the elderly, patients with renal function impairment and patients with a very high or very low body weight. Read More

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http://dx.doi.org/10.12890/2018_001000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346970PMC
December 2018
1 Read

Hypersensitivity reaction with multi-organ failure following re-exposure to rifampicin: case report and review of the literature including WHO spontaneous safety reports.

BMC Pharmacol Toxicol 2019 Feb 12;20(1). Epub 2019 Feb 12.

Department of Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland.

Background: True hypersensitivity reactions to rifampicin are relatively rare, nonetheless severe manifestations mostly involving a single organ have been documented. We report a case of acute multi-organ failure occurring after a medication error with re-exposure to rifampicin.

Case Presentation: A 68-year old patient developed acute hypersensitivity pneumonitis, acute renal failure, acute liver failure and haemolytic anemia within hours after a second re-exposure to Rifampicin for the treatment of a hip prosthesis infection with Staphylococcus epidermidis. Read More

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http://dx.doi.org/10.1186/s40360-019-0289-7DOI Listing
February 2019
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Clinical Spectrum of Primaquine-induced Hemolysis in G6PD Deficiency: A Nine-Year Hospitalization-Based Study from the Brazilian Amazon.

Clin Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Brazil.

Despite G6PDd prevalence of 5% in the Amazon, primaquine is administered without G6PD screening. This is an important cause of hospitalization among Plasmodium vivax-infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, the frequency of primaquine-induced hemolysis was 85. Read More

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http://dx.doi.org/10.1093/cid/ciz122DOI Listing
February 2019
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Impact of decreased ankle-brachial index on 30-day bleeding complications and long-term mortality in patients with acute coronary syndrome after percutaneous coronary intervention.

J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Background: Although concomitant peripheral artery disease in patients with acute coronary syndrome (ACS) has been considered as a high-risk subgroup with a greater incidence of bleeding after percutaneous coronary intervention (PCI), few data exist regarding the clinical utility of the ankle-brachial index (ABI) for predicting bleeding complications, which affects the subsequent outcome.

Methods: Eight hundred and twenty-four consecutive patients with ACS who underwent PCI and ABI examination were analyzed retrospectively. Decreased-ABI was defined as ABI <0. Read More

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http://dx.doi.org/10.1016/j.jjcc.2019.01.008DOI Listing
February 2019
2 Reads

Life-Threatening Complications among Women with Severe Ovarian Hyperstimulation Syndrome.

Am J Obstet Gynecol 2019 Feb 8. Epub 2019 Feb 8.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Columbia University Medical Center, 5 Columbus Circle, PH, New York, NY 10019.

Background: Ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening clinical condition.

Objective: The objective of this study was to evaluate risk factors for life-threatening complications for patients with severe OHSS in a United States nationwide sample.

Materials And Methods: OHSS admissions from 2002-2011 from the Nationwide Inpatient Sample (NIS) were included in this study. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.009DOI Listing
February 2019
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[Etiologyical Analysis of 133 Patients with Elderly Macrocytic Anemia and Diagnostic Significance of Laboratory Tests].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Feb;27(1):202-207

Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China.

Objective: To study the etiology of macrocytic anemia in elderly patients and to evaluate the diagnostic significance of laborotory tests.

Methods: 133 elderly macrocytic anemia patients, whose age>60 years old, hemoglobin<100 g/L, mean red cell volume(MCV)>100 fL, and bone marrow cell test was performed, and these patients were grouped according to diseases, and the bilirubin, lactate dehydrogenase, folic acid, vit B12 and serum ferritin were tested, then the results of tests were compared and analyzed.

Results: The majority of the cases were diagnosed as megaloblastic anemia (MA), myelodysplasia syndrome (MDS), acute leukemia/multiple myeloma (AL/MM) and hemolytic anemia (HA). Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2019.01.033DOI Listing
February 2019
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The contribution of red blood cell transfusion to neonatal morbidity and mortality.

J Paediatr Child Health 2019 Feb 8. Epub 2019 Feb 8.

Robinson Research Institute, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.

Anaemia of prematurity will affect 90% of all very preterm infants, resulting in at least one red blood cell (RBC) transfusion. A significant proportion of preterm infants require multiple transfusions over the course of hospital admission. Growing evidence supports an association between transfusion exposure and adverse neonatal outcomes. Read More

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http://doi.wiley.com/10.1111/jpc.14402
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http://dx.doi.org/10.1111/jpc.14402DOI Listing
February 2019
3 Reads

Regulation and tissue-specific expression of δ-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias.

Mol Genet Metab 2019 Jan 23. Epub 2019 Jan 23.

INSERM U1149, CNRS ERL 8252, Centre de Recherche sur l'inflammation, Université Paris Diderot, site Bichat, Sorbonne Paris Cité, France, 16 rue Henri Huchard, 75018 Paris, France; Laboratory of Excellence, GR-Ex, Paris, France; AP-HP, HUPNVS, Centre Français des Porphyries, Hôpital Louis Mourier, Colombes, France. Electronic address:

Recently, new genes and molecular mechanisms have been identified in patients with porphyrias and sideroblastic anemias (SA). They all modulate either directly or indirectly the δ-aminolevulinic acid synthase (ALAS) activity. ALAS, is encoded by two genes: the erythroid-specific (ALAS2), and the ubiquitously expressed (ALAS1). Read More

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http://dx.doi.org/10.1016/j.ymgme.2019.01.015DOI Listing
January 2019
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Murine models of the human porphyrias: Contributions toward understanding disease pathogenesis and the development of new therapies.

Mol Genet Metab 2019 Jan 18. Epub 2019 Jan 18.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Mouse models of the human porphyrias have proven useful for investigations of disease pathogenesis and to facilitate the development of new therapeutic approaches. To date, mouse models have been generated for all major porphyrias, with the exception of X-linked protoporphyria (XLP) and the ultra rare 5-aminolevulinic acid dehydratase deficient porphyria (ADP). Mouse models have been generated for the three autosomal dominant acute hepatic porphyrias, acute intermittent porphyria (AIP), hereditary coproporphyria (HCP), and variegate porphyria (VP). Read More

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http://dx.doi.org/10.1016/j.ymgme.2019.01.007DOI Listing
January 2019
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Malaria Severity in Mangaluru City in the Southwestern Coastal Region of India.

Am J Trop Med Hyg 2019 Feb;100(2):275-279

Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania.

Dakshina Kannada district in the Southwestern region of Karnataka state, India, including Mangaluru city is endemic to malaria. About 80% of malaria infections in Mangaluru and its surrounding areas are caused by and the remainder is due to . Malaria-associated clinical complications significantly occur in this region. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367599PMC
February 2019
2 Reads

A different clinical presentation of Heiner syndrome: The case of diffuse alveolar hemorrhage causing massive hemoptysis and hematemesis.

Respir Med Case Rep 2019 23;26:206-208. Epub 2019 Jan 23.

Department of Pediatric, University of Health Sciences, Adana Health Practices and Research Center, Adana, Turkey.

Heiner syndrome is a non-IgE-mediated hypersensitivity to cow's milk, which often causes pulmonary disease in infants and young children. Patients often have symptoms of chronic or recurrent upper or lower respiratory tract infection. It has been reported that the Heiner's syndrome can cause recurrent pulmonary hemorrhage, and it is difficult to differentiate from the entity of idiopathic pulmonary hemosiderosis, another disease with recurrent pulmonary hemorrhage of unknown etiology usually occurring in the older children. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354653PMC
January 2019
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Sub-acute oral exposure of zinc oxide nanoparticles causes alteration in iron homeostasis through acute phase response: A protective effect by surface modification.

J Trace Elem Med Biol 2019 Mar 14;52:270-287. Epub 2019 Jan 14.

Biochemistry Laboratory, Animal Facility, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India. Electronic address:

Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanomaterials. Following oral exposure, these NPs can accumulate in various organs and induce the toxicity due to their physiochemical characteristics. In present study to reduce the toxicity, surface engineered ZnO NPs (c-ZnO NPs) were in-situ synthesized by using polyacrylamide grafted guar gum (PAm-g-GG) polymer in alkaline media. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.008DOI Listing
March 2019
2 Reads
2.491 Impact Factor

First molecular evidence of bovine hemoplasma species (Mycoplasma spp.) in water buffalo and dairy cattle herds in Cuba.

Parasit Vectors 2019 Feb 7;12(1):78. Epub 2019 Feb 7.

Clinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Background: Hemotropic mycoplasmas (aka hemoplasmas) are small bacteria which cause infectious anemia in several mammalian species including humans. Information on hemoplasma infections in Cuban bovines remains scarce and no studies applying molecular methods have been performed so far. The aim of the present study was to utilize real-time PCR and sequence analysis to investigate dairy cattle and buffalo from Cuba for the presence of bovine hemoplasma species. Read More

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http://dx.doi.org/10.1186/s13071-019-3325-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367761PMC
February 2019
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Spontaneous Rectus Sheath Hematoma: An Uncommon Cause of Acute Abdominal Pain.

Am J Case Rep 2019 Feb 7;20:163-166. Epub 2019 Feb 7.

Department of Internal Medicine, United Health Services Hospitals, Wilson Medical Center, Johnson City, NY, USA.

BACKGROUND A clinical condition that is often misdiagnosed, rectus sheath hematoma (RSH) is usually seen in the context of blunt abdominal trauma and/or anticoagulation therapy, rarely occurring spontaneously. We present a case of spontaneous rectus sheath hematoma (SRSH) without obvious risk factors and review the literature regarding diagnosis modalities and management. The aim of this case presentation is to highlight this rare clinical condition and emphasize the role of the physical exam in determining the appropriate treatment approach. Read More

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http://dx.doi.org/10.12659/AJCR.913246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375283PMC
February 2019
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A Unique Case of Severe Anemia Secondary to Copper Deficiency in an Adult Patient.

Cureus 2018 Nov 26;10(11):e3636. Epub 2018 Nov 26.

Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA.

Anemia is a frequently encountered problem in the healthcare system. Common causes of anemia include blood loss, followed by impaired red blood cell production and red blood cell destruction. This case demonstrates the need for cognizance of the less frequent causes of anemia. Read More

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http://dx.doi.org/10.7759/cureus.3636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351007PMC
November 2018

Rapunzel syndrome in adult with mysterious presentation: a rare case report with literature review.

Trop Doct 2019 Feb 5:49475519826477. Epub 2019 Feb 5.

6 Junior Resident, Department of General Surgery, All India Institute of Medical Sciences Rishikesh, India.

Bezoars are indigestible foreign material in the gastrointestinal tract (GIT). A phytobezoar is a mass of plant material, while a trichobezoar consists of matted hair. This is found most commonly in the stomach in children who chew their long hair. Read More

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http://dx.doi.org/10.1177/0049475519826477DOI Listing
February 2019
2 Reads

Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma.

Blood Cancer J 2019 Feb 4;9(2):17. Epub 2019 Feb 4.

Sarah Cannon Research Institute, Nashville, TN, USA.

FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. This phase I study assessed safety, tolerability, maximum tolerated dose (MTD), anti-tumor activity, and pharmacokinetics of DFRF4539A in patients with relapsed/refractory multiple myeloma. Read More

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http://dx.doi.org/10.1038/s41408-019-0178-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362066PMC
February 2019
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Ramucirumab with cisplatin and fluoropyrimidine as first-line therapy in patients with metastatic gastric or junctional adenocarcinoma (RAINFALL): a double-blind, randomised, placebo-controlled, phase 3 trial.

Lancet Oncol 2019 Feb 1. Epub 2019 Feb 1.

Weill Cornell Medical College, NY, USA; New York Presbyterian Hospital, New York, NY, USA.

Background: VEGF and VEGF receptor 2 (VEGFR-2)-mediated signalling and angiogenesis can contribute to the pathogenesis and progression of gastric cancer. We aimed to assess whether the addition of ramucirumab, a VEGFR-2 antagonist monoclonal antibody, to first-line chemotherapy improves outcomes in patients with metastatic gastric or gastro-oesophageal junction adenocarcinoma.

Methods: For this double-blind, randomised, placebo-controlled, phase 3 trial done at 126 centres in 20 countries, we recruited patients aged 18 years or older with metastatic, HER2-negative gastric or gastro-oesophageal junction adenocarcinoma, an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, and adequate organ function. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30791-5DOI Listing
February 2019
9 Reads
24.690 Impact Factor

Liberal transfusion strategy to prevent mortality and anaemia-associated, ischaemic events in elderly non-cardiac surgical patients - the study design of the LIBERAL-Trial.

Trials 2019 Feb 4;20(1):101. Epub 2019 Feb 4.

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

Background: Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, anaemia can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because of multiple co-morbidities and age-related decline of functional reserves. Read More

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http://dx.doi.org/10.1186/s13063-019-3200-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360712PMC
February 2019
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The link between anemia and adverse outcomes in patients with acute coronary syndrome.

Expert Rev Cardiovasc Ther 2019 Feb 4:1-9. Epub 2019 Feb 4.

a The Zena and Michael A. Weiner Cardiovascular Institute , The Icahn School of Medicine at Mount Sinai , New York , USA.

Introduction: Anemia is one of the most frequent comorbidities in acute coronary syndrome (ACS) patients and is associated with a significant impact on clinical outcomes. This review summarizes the knowledge and updated management of anemia in the setting of ACS. Areas covered: We provide a review on the prevalence, pathophysiology, prognosis, impact, and updated management of anemia. Read More

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http://dx.doi.org/10.1080/14779072.2019.1575729DOI Listing
February 2019
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Endogenous Erythropoietin and Hepatic Dysfunction in Acute Kidney Injury Requiring Renal Replacement Therapy.

Nephron 2019 Feb 1:1-7. Epub 2019 Feb 1.

Department of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo, Japan.

Backgrounds/Objectives: Elevated erythropoietin (EPO) is observed in human acute kidney injury (AKI). Whether blood EPO level is associated with mortality or other organ dysfunction in critically ill patients is unknown.

Methods: A prospective observational cohort study of 162 AKI patients requiring renal replacement therapy (RRT) was conducted in our intensive care unit (ICU) during October 2013 through October 2016. Read More

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http://dx.doi.org/10.1159/000496618DOI Listing
February 2019
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Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria in the Age of Eculizumab.

Biol Blood Marrow Transplant 2019 Jan 31. Epub 2019 Jan 31.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Medical Oncology, Department of Medicine. Electronic address:

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired clonal hematopoietic cell disease characterized by destruction of hematopoietic cells through the activation of the complement system with manifestations that can be life threatening including hemolysis, thrombosis, and marrow failure. Allogeneic hematopoietic cell transplantation (HCT) remains the only cure for PNH, but eculizumab, a terminal complement inhibitor of C5, has been used to prevent complement mediated hemolysis in PNH since its FDA approval in 2007. We examined outcomes of HCT in PNH patients to evaluate the effects of disease subtype, conditioning intensity, and eculizumab use either pre- or post-HCT. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.01.033DOI Listing
January 2019
2 Reads

Comorbidity assessment for mortality risk stratification in elderly patients with acute coronary syndrome.

Eur J Intern Med 2019 Jan 31. Epub 2019 Jan 31.

Servei de Cardiologia, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Background: The Charlson's is the most used comorbidity index. It comprises 19 comorbidities, some of which are infrequent in elderly patients with acute coronary syndrome (ACS), while some others are manifestations of cardiac disease rather than comorbidities. Our goal was to simplify comorbidity assessment in elderly non-ST-segment elevation ACS patients. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.018DOI Listing
January 2019
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Inhaled nitric oxide prevents systemic and pulmonary vasoconstriction due to hemoglobin-based oxygen carrier infusion: A case report.

J Crit Care 2019 Jan 29. Epub 2019 Jan 29.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:

Hemoglobin-based oxygen carriers (HBOCs) are used in extreme circumstances to increase hemoglobin concentration and improve oxygen delivery when allogenic red blood cell transfusions are contraindicated or not immediately available. However, HBOC-induced severe pulmonary and systemic vasoconstriction due to peripheral nitric oxide (NO) scavenging has stalled its implementation in clinical practice. We present a case of an 87 year-old patient with acute life-threatening anemia who received HBOC while breathing NO gas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183020
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http://dx.doi.org/10.1016/j.jcrc.2018.04.008DOI Listing
January 2019
4 Reads

Post-allogeneic eculizumab as prophylaxis against hemolysis and thrombosis for patients with hematologic disorders associated with PNH clones.

Biol Blood Marrow Transplant 2019 Jan 29. Epub 2019 Jan 29.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA; Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA.

Paroxysmal nocturnal hemoglobinuria (PNH) is frequently seen in the context of other aplastic anemia and myelodysplastic syndrome and is associated with hemolysis and increased thromboembolic events. Allogeneic hematopoietic stem cell transplantation (alloHCT) is the only curative treatment but is associated with significant morbidity. The terminal complement inhibitor eculizumab reduces hemolysis and thromboembolic events and is the only FDA-approved therapy for PNH. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.01.025DOI Listing
January 2019
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Erythropoietic Protoporphyria and X-Linked Protoporphyria: pathophysiology, genetics, clinical manifestations, and management.

Authors:
Manisha Balwani

Mol Genet Metab 2019 Jan 24. Epub 2019 Jan 24.

Department of Genetics and Genomic Sciences and Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address:

Erythropoietic Protoporphyria (EPP) and X-linked Protoporphyria (XLP) are rare, genetic photodermatoses resulting from defects in enzymes of the heme-biosynthetic pathway. EPP results from the partial deficiency of ferrochelatase, and XLP results from gain-of-function mutations in erythroid specific ALAS2. Both disorders result in the accumulation of erythrocyte protoporphyrin, which is released in the plasma and taken up by the liver and vascular endothelium. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10967192183064
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http://dx.doi.org/10.1016/j.ymgme.2019.01.020DOI Listing
January 2019
2 Reads

Aerobic physical exercise for adult patients with haematological malignancies.

Cochrane Database Syst Rev 2019 01 31;1:CD009075. Epub 2019 Jan 31.

Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Kerpener Str. 62, Cologne, Germany.

Background: Although people with haematological malignancies have to endure long phases of therapy and immobility, which is known to diminish their physical performance level, the advice to rest and avoid intensive exercises is still common practice. This recommendation is partly due to the severe anaemia and thrombocytopenia from which many patients suffer. The inability to perform activities of daily living restricts them, diminishes their quality of life and can influence medical therapy. Read More

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http://dx.doi.org/10.1002/14651858.CD009075.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354325PMC
January 2019
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Hematopoietic stem cell transplantation with alpha/beta T-lymphocyte depletion and short course of eculizumab in adolescents and young adults with paroxysmal nocturnal hemoglobinuria.

Ter Arkh 2018 Aug;90(7):57-64

Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Department of optimization treatment and prevention of complications of hematopoietic stem cell transplantation, Moscow, Russia.

Aim: The main goal is to optimize hematopoietic stem cell transplantation (HSCT) approach among adolescents and young adults with paroxysmal nocturnal hemoglobinuria (PNH) by means of Graft-versus-host disease (GVHD) and post-transplant complications risk lowering.

Materials And Methods: We report our experience of HSCT from HLA-matched unrelated donors using TCR alfa/beta and CD19 depletion in 5 pts (1M/4F) with PNH, developed after successful immunosuppressive therapy (IST) of acquired aplastic anemia (AA). Median age of pts at the moment of transplantation was 17,8 years (range 14,5-22,7), median interval from IST to PNH was 4 years (5mo - 6,5 y). Read More

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http://dx.doi.org/10.26442/terarkh201890757-64DOI Listing
August 2018
4 Reads

Early -induced inflammation does not accelerate aging in mice.

Evol Appl 2019 Feb 17;12(2):314-323. Epub 2018 Oct 17.

Biogéosciences, CNRS UMR 6282 Université de Bourgogne Franche-Comté Dijon France.

Aging is associated with a decline of performance leading to reduced reproductive output and survival. While the antagonistic pleiotropy theory of aging has attracted considerable attention, the molecular/physiological functions underlying the early-life benefits/late-life costs paradigm remain elusive. We tested the hypothesis that while early activation of the inflammatory response confers benefits in terms of protection against infection, it also incurs costs in terms of reduced reproductive output at old age and shortened longevity. Read More

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http://dx.doi.org/10.1111/eva.12718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346666PMC
February 2019

The Management of Heavy Menstrual Bleeding After Percutaneous Coronary Intervention in a Woman of Reproductive Age.

Front Pharmacol 2018 15;9:1573. Epub 2019 Jan 15.

Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia. We reported a rare case of HMB in a 33-year-old patient after percutaneous coronary intervention (PCI), who presented with acute coronary syndromes (ACS), uremia and systemic lupus erythematosus before PCI. This patient received three times of hemodialysis weekly (Monday, Wednesday, and Friday). Read More

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http://dx.doi.org/10.3389/fphar.2018.01573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341068PMC
January 2019
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Acute pancreatitis associated with massive bleeding due to a duodenal ulcer.

Clin J Gastroenterol 2019 Jan 29. Epub 2019 Jan 29.

Department of Gastroenterology, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.

A 74-year-old man presented to the emergency department with acute abdominal pain in addition to anemia and melena, which were suspected to be due to gastrointestinal bleeding. Computed tomography (CT) revealed a blood-filled duodenum and acute pancreatitis. We prioritized treatments for pancreatitis, as the vital signs were stable, and temporary hemostasis was achieved. Read More

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http://dx.doi.org/10.1007/s12328-019-00942-6DOI Listing
January 2019
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The Influence of Modifiable, Postoperative Patient Variables on the Length of Stay After Total Hip Arthroplasty.

J Arthroplasty 2019 Jan 6. Epub 2019 Jan 6.

Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, GA.

Background: Many studies have examined strategies to reduce length of stay (LOS) after total hip arthroplasty (THA), but few have focused on modifiable patient-specific information in the acute postoperative period. This study investigates the determinants of LOS after THA, with a focus on potentially modifiable factors.

Methods: A total of 1278 patients undergoing elective THA from 2012 to 2014 were extracted from our institutional data warehouse at our academic orthopedic specialty hospital. Read More

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http://dx.doi.org/10.1016/j.arth.2018.12.041DOI Listing
January 2019

[Acute Suppurative Appendicitis Diagnosed by Acute Lower Gastrointestinal Hemorrhage].

Korean J Gastroenterol 2019 Jan;73(1):45-49

Division of Gastroenterology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.

A 49-year-old man visited the emergency room of Korea University Ansan Hospital with hematochezia starting the day before the visit. Recently, he was on anti-platelet medication due to hypertension. The patient had no definite symptoms other than hematochezia. Read More

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http://dx.doi.org/10.4166/kjg.2019.73.1.45DOI Listing
January 2019
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Association between MTHFR 677C>T polymorphism and vascular complications in sickle cell disease: A meta-analysis.

Transfus Clin Biol 2019 Jan 10. Epub 2019 Jan 10.

Sickle Cell Institute Chhattisgarh, Forest Block-2, Jail Road, Raipur 492001, Chhattisgarh India. Electronic address:

Sickle cell disease (SCD) is considered as a vascular disease due to its chronic vascular manifestations such as leg ulcers, priapism, acute chest syndrome (ACS), stroke, retinopathy, renal insufficiency, pulmonary hypertension, avascular necrosis of the femoral head (AVNF) and splenic infarction. Emerging evidence has shown that the MTHFR 677C>T variant allele is associated with vascular complications (VC) in patients with SCD; however, results from individual studies are inconclusive. The aim of this meta-analysis is to evaluate the association between the MTHFR 677C>T polymorphism and the susceptibility for VC in SCD patients. Read More

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http://dx.doi.org/10.1016/j.tracli.2019.01.003DOI Listing
January 2019
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Anemia and postoperative outcomes after open and endovascular repair of intact abdominal aortic aneurysms.

J Vasc Surg 2019 Jan 23. Epub 2019 Jan 23.

Department of Surgery, The Johns Hopkins Bayview Vascular and Endovascular Research Laboratory, Baltimore, Md. Electronic address:

Objective: Anemia is associated with increased cardiac adverse events during the early postoperative period because of high physiologic stress and increased cardiac demand. The aim of this study was to assess the surgical outcomes and prognostic implications of anemia in patients undergoing repair of intact abdominal aortic aneurysms (AAAs).

Methods: A retrospective analysis of all patients who underwent open aortic repair (OAR) or endovascular aneurysm repair (EVAR) in the Vascular Quality Initiative database (2008-2017) was performed. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.05.233DOI Listing
January 2019
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Adherence to clinical guidelines is associated with reduced inpatient mortality among children with severe anemia in Ugandan hospitals.

PLoS One 2019 25;14(1):e0210982. Epub 2019 Jan 25.

Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: In resource limited settings, there is variability in the level of adherence to clinical guidelines in the inpatient management of children with common conditions like severe anemia. However, there is limited data on the effect of adherence to clinical guidelines on inpatient mortality in children managed for severe anemia.

Methods: We analyzed data from an uncontrolled before and after in-service training intervention to improve quality of care in Lira and Jinja regional referral hospitals in Uganda. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210982PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347145PMC
January 2019
4 Reads

Outcomes of trans-radial PCI compared to trans-femoral PCI in veterans with anemia: Insight from the VA Clinical Assessment, Reporting and Tracking (CART) program.

Cardiovasc Revasc Med 2019 Jan 14. Epub 2019 Jan 14.

University of Colorado-School of Medicine, Aurora, CO, United States of America; VA Rocky Mountain Regional Medical Center, Aurora, CO, United States of America.

Background: Pre-procedural anemia is associated with increased bleeding and mortality post-percutaneous coronary intervention (PCI). The effect of trans-radial PCI (TR-PCI) in improving outcomes compared to trans-femoral PCI (TF-PCI) in anemic patients is not known.

Objective: The aim of this study was to evaluate the association between arterial access site (radial versus femoral) and outcomes in anemic Veterans undergoing PCI. Read More

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http://dx.doi.org/10.1016/j.carrev.2019.01.014DOI Listing
January 2019

MDS overlap disorders and diagnostic boundaries.

Blood 2019 Jan 22. Epub 2019 Jan 22.

Division of Hematology and Oncology, University of California, San Diego, Moores Cancer Center, La Jolla, CA, United States

Myelodysplastic syndromes (MDS) are clonal diseases defined by clinical, morphologic and genetic features often shared by related myeloid disorders. The diagnostic boundaries between these diseases can be arbitrary and not necessarily reflective of underlying disease biology or outcomes. In practice, measures that distinguish MDS from related disorders may be difficult to quantify and can vary as disease progression occurs. Read More

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http://dx.doi.org/10.1182/blood-2018-10-844670DOI Listing
January 2019
1 Read