234,329 results match your criteria Anemia and Thrombocytopenia in Pregnancy

Malnutrition prevalence and associated biochemical factors among drug-resistance tuberculosis (DR-TB) patients at key treatment sites in Conakry City, Republic of Guinea.

Pan Afr Med J 2021 17;38:279. Epub 2021 Mar 17.

National AIDS and Hepatitis Control Program, Guinea.

Introduction: drug-resistant tuberculosis is a major global health problem and a threat to health security given the increase in the number of cases and the challenges associated with care. Besides, the relationship between poor nutritional status and tuberculosis is clearly established. For relevant and evidence-based public health decision-making regarding the management of malnutrition in patients with drug-resistant tuberculosis in the initial phase, it is essential to estimate the prevalence of malnutrition and understand the risk factors associated with it. Read More

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Prenatal Genetic Counseling in a Chinese Pregnant Woman With Rare Thalassemia: A Case Report.

Front Genet 2021 28;12:670168. Epub 2021 May 28.

Department of Endocrinology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Prenatal genetic counseling can be difficult, especially when it is related to fetuses with a rare thalassemia. An intronic variant located far from obvious regulatory sequences in the gene could be very difficult to evaluate as it may affect the mRNA processing or cause β-thalassemia (β-thal). In the present study, a Chinese pregnant woman with HbJ-Bangkok and a very rare change in the second intron of the gene [IVS-II-806(G>C), NM_000518. Read More

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Four New Cases of SLC35A2-CDG With Novel Mutations and Clinical Features.

Front Genet 2021 27;12:658786. Epub 2021 May 27.

Department of Hepatology, Children's Hospital of Fudan University, Shanghai, China.

SLC35A2-CDG is a rare type of X-linked CDG with more than 60 reported cases. We retrospectively analyzed clinical phenotypes and genotypes of four cases of SLC35A2-CDG from four unrelated families of Han ethnicity in China. All patients had infantile onset epilepsies that were completely or partly resistant to multiple anti-epileptic medications or ketogenic diet. Read More

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Answered and Unanswered Questions in Early-Stage Viral Vector Transduction Biology and Innate Primary Cell Toxicity for Gene Editing.

Front Immunol 2021 28;12:660302. Epub 2021 May 28.

Department of Pediatrics, Stanford University, Stanford, CA, United States.

Adeno-associated virus is a highly efficient DNA delivery vehicle for genome editing strategies that employ CRISPR/Cas9 and a DNA donor for homology-directed repair. Many groups have used this strategy in development of therapies for blood and immune disorders such as sickle-cell anemia and severe-combined immunodeficiency. However, recent events have called into question the immunogenicity of AAV as a gene therapy vector and the safety profile dictated by the immune response to this vector. Read More

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The Role of Plasma Neurofilament Light Protein for Assessing Cognitive Impairment in Patients With End-Stage Renal Disease.

Front Aging Neurosci 2021 28;13:657794. Epub 2021 May 28.

TMU Research Center of Cancer Translational Medicine, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.

End-stage renal disease (ESRD) is defined as the irreversible loss of renal function, necessitating renal replacement therapy. Patients with ESRD tend to have more risk factors for cognitive impairment than the general population, including hypertension, accumulative uremic toxin, anemia, and old age. The association between these risk factors and the pathologic protein was lacking. Read More

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What is the impact of thyroidectomy on autoimmune features associated with Hashimoto's thyroiditis?-Institutional experience.

Niger J Clin Pract 2021 Jun;24(6):905-910

Pinnamaneni Siddartha Institute of Medical Sciences (PSIMS), Gannavaram, Vijayawada, AP, India.

Background: Hashimoto's thyroiditis (HT) is one of the commonest endocrine disorders, globally. Often, HT presents a protean range of associated autoimmune features (AAI) such as vitiligo, rheumatoid arthritis, pernicious anemia, skin allergy/atopy, thrombocytopenia, Addison's disease, type 1 diabetes, celiac disease, eosinophilia, etc., The usual treatment of HT is symptomatic with no curative option. Read More

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Co-Inheritance of α-thalassemia gene mutation in patients with sickle cell Disease: Impact on clinical and hematological variables.

Niger J Clin Pract 2021 Jun;24(6):874-882

Department of Pediatrics, College of Medicine, University of Basra, Basra, Iraq.

Background: Sickle cell disease (SCD) is a monogenic, phenotypically highly variable disease with multisystem pathology. The phenotypic heterogeneity of SCD is attributed to environmental and genetic factors such as fetal hemoglobin and co-inheritance of α-thalassemia.

Objectives: To look for different types of α-thalassemia gene mutations among SCD patients and evaluate the influence of the co-inheritance of α-thalassemia on clinical and hematological variables. Read More

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Role of glutathione S-transferase P1 polymorphism in early transplant complications in patients undergoing allogeneic stem cell transplantation.

J Cancer Res Ther 2021 Apr-Jun;17(2):565-573

Department of Haemotology, Medical Park Hospital, Şişli, Istanbul, Turkey.

Introduction: Complications in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) cause serious morbidity and mortality. Predicting patients at risk in advance and changing the symptomatic care and/or preparation regimen according to this risk assessment have been emphasized recently. Several single-nucleotide polymorphisms have been studied, and some were found to be responsible for early complications. Read More

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Recurrent aplastic anemia with donor-type aplasia: A rare occurrence in the Indian subcontinent.

J Postgrad Med 2021 Jun 9. Epub 2021 Jun 9.

Department of Pathology, ABVIMS and Dr. RML Hospital, New Delhi, India.

Donor-type aplasia (DTA) is a condition where an individual continues to be aplastic even after a successful engraftment of a hematopoeitic stem cell transplant with a majority of donor type cells in the bone marrow. This entity has been seen with varying frequency around the world, especially in Southeast Asia. However, its incidence in the Indian subcontinent remains fairly low. Read More

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Risk factors and predictive model for abdominal wound dehiscence in neonates: a retrospective cohort study.

Ann Med 2021 Dec;53(1):900-907

Department of Pediatric Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.

Background: Abdominal wound dehiscence (AWD) is a major complication of abdominal surgery, and neonates are a group with a high risk of AWD, which has serious consequences or can even result in death. The purpose of this study is to explore the risk factors for neonatal AWD and construct a predictive model.

Methods: The clinical data of 453 cases that underwent neonatal laparotomy from June 2009 to June 2020 were retrospectively analyzed, among which 27 cases of AWD were identified. Read More

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December 2021

The relationship between anaemia and poor outcomes: let's get to the meat of the matter.

Anaesthesia 2021 Jun 14. Epub 2021 Jun 14.

Department of Anesthesia and Pain Medicine, University of Toronto, Toronto, ON, Canada.

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Capnocytophaga Sputigena Sepsis in a Severe Aplastic Anemia Patient.

Intern Med 2021 Jun 12. Epub 2021 Jun 12.

¹Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Japan.

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Pseudo-thrombotic Microangiopathy Caused by Acquired Cobalamin Deficiency Due to Unintentional Neglect: A Case Report.

Intern Med 2021 Jun 12. Epub 2021 Jun 12.

Department of General Medicine and Emergency Care, Toho University School of Medicine.

Acquired vitamin B (VB) deficiency is a rare cause of thrombotic microangiopathy (TMA). We experienced an 86-year-old Japanese woman who presented with coma, renal dysfunction, and microangiopathic hemolytic anemia. Although we initially considered thrombotic thrombocytopenic purpura, we eventually diagnosed her to have VB deficiency due to inappropriate dietary care based on her low serum VB level, social history, and negative parietal cell finding and the presence of intrinsic factor antibody. Read More

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Infantile pyknocytosis with marked hemolytic anemia.

Pediatr Neonatol 2021 Jun 2. Epub 2021 Jun 2.

Department of Pediatrics, National Hospital Organization Okayama Medical Center, Okayama, Japan.

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Associations of the pre-pregnancy weight status with anemia and the erythropoiesis-related micronutrient status.

Public Health Nutr 2021 Jun 14:1-31. Epub 2021 Jun 14.

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.

Objective: The coexistence of underweight (UW) and overweight (OW)/obese (OB) at the population level is known to affect iron-deficiency anemia (IDA), but how the weight status affects erythropoiesis during pregnancy is less clear at a population scale. This study investigated associations between the pre-pregnancy body mass index (pBMI) and erythropoiesis-related nutritional deficiencies.

Design: Anthropometry, blood biochemistry, and 24-h dietary recall data were collected during prenatal care visits. Read More

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Anaemia: A risk factor for death and adverse outcomes following surgery for acute lower limb ischaemia.

Vascular 2021 Jun 13:17085381211026167. Epub 2021 Jun 13.

Northern Vascular Centre, Freeman Hospital, Newcastle-upon-Tyne Hospitals, Newcastle, UK.

Introduction: Acute limb ischaemia (ALI) forms a significant part of the vascular surgery workload and carries with it high rates of morbidity and mortality. Anaemia is also common amongst vascular surgical patients and has been linked with poor outcomes in some subgroups. We aimed to assess the frequency of anaemia in patients with ALI and its impact on survival and complications following revascularisation to help direct future efforts to optimise outcomes in this patient group. Read More

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Red cell distribution width, anemia and their associations with white matter integrity among middle-aged urban adults.

Neurobiol Aging 2021 May 21;105:229-240. Epub 2021 May 21.

Department of Psychology, University of Maryland Baltimore County, Catonsville, MD, USA; Geriatric Research Education and Clinical Center, Baltimore VA Medical Center, Baltimore, MD, USA; Division of Gerontology & Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Anemia (blood hemoglobin [Hb] <13 g/dL among males; <12 g/dL among females) and elevated red cell distribution width (RDW) are potential risk factors for reduced brain white matter integrity (WMI), reflected by lower fractional anisotropy or increased mean diffusivity. Cross-sectional data with exposure-outcome lag time was used, whereby hematological exposures (RDW and Hb) and covariates were compiled from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study with available visit 1 (v; 2004-2009) and/or v (2009-2013) data; while diffusion tensor magnetic resonance imaging (dMRI) outcome data were collected at HANDLS SCAN visit (v: 2011-2015, n = 214, mean follow-up from v ±SD: 5.6 ± 1. Read More

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Heart Failure Hospitalization in Adults Receiving Hemodialysis and the Effect of Intravenous Iron Therapy.

JACC Heart Fail 2021 Jun 3. Epub 2021 Jun 3.

Department of Renal Medicine, King's College Hospital, London, United Kingdom.

Objectives: The study sought to examine the effect of intravenous iron on heart failure events in hemodialysis patients.

Background: Heart failure is a common and deadly complication in patients receiving hemodialysis and is difficult to diagnose and treat.

Methods: The study analyzed heart failure events in the PIVOTAL (Proactive IV Iron Therapy in Hemodialysis Patients) trial, which compared intravenous iron administered proactively in a high-dose regimen with a low-dose regimen administered reactively. Read More

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A homozygous nonsense mutation early in exon 5 of BRCA2 is associated with very severe Fanconi anemia.

Eur J Med Genet 2021 Jun 10;64(8):104260. Epub 2021 Jun 10.

Department of Pediatrics III, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany; Department of Otorhinolaryngology & Head/Neck Surgery, University Hospital Düsseldorf, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

Fanconi anemia (FA) due to biallelic mutations in the BRCA2 gene is very rare and associated with an extremely high risk of early-onset of aggressive childhood malignancies, predominantly brain tumors, leukemia, and nephroblastoma. Here, we present a consanguineous family with three affected children of the D1 subtype of FA and describe the clinical consequences of the earliest known biallelic nonsense/stop-gain germ-line mutation in BRCA2, exon 5 c.469A>T, that leads to a premature stop of translation, p. Read More

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The advantages of capsule endoscopy in the anemia algorithm for tapeworm recognition.

Gastroenterol Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Gastroenterology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.

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Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1/2 study.

Lancet Diabetes Endocrinol 2021 Jun 9. Epub 2021 Jun 9.

Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR, USA.

Background: Oncogenic alterations in RET represent important therapeutic targets in thyroid cancer. We aimed to assess the safety and antitumour activity of pralsetinib, a highly potent, selective RET inhibitor, in patients with RET-altered thyroid cancers.

Methods: ARROW, a phase 1/2, open-label study done in 13 countries across 71 sites in community and hospital settings, enrolled patients 18 years or older with RET-altered locally advanced or metastatic solid tumours, including RET-mutant medullary thyroid and RET fusion-positive thyroid cancers, and an Eastern Co-operative Oncology Group performance status of 0-2 (later limited to 0-1 in a protocol amendment). Read More

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Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study.

Lancet Oncol 2021 Jun 9. Epub 2021 Jun 9.

Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Oncogenic alterations in RET have been identified in multiple tumour types, including 1-2% of non-small-cell lung cancers (NSCLCs). We aimed to assess the safety, tolerability, and antitumour activity of pralsetinib, a highly potent, oral, selective RET inhibitor, in patients with RET fusion-positive NSCLC.

Methods: ARROW is a multi-cohort, open-label, phase 1/2 study done at 71 sites (community and academic cancer centres) in 13 countries (Belgium, China, France, Germany, Hong Kong, Italy, Netherlands, Singapore, South Korea, Spain, Taiwan, the UK, and the USA). Read More

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Mesenchymal Stem Cells: A Novel Therapeutic Approach to Enhance Protective Immunomodulation and Erythropoietic Recovery in Malaria.

Stem Cell Rev Rep 2021 Jun 12. Epub 2021 Jun 12.

Parasite-Host Biology, National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, 110077, India.

Mesenchymal stem cells (MSCs) are self-renewing, multi-potent heterogeneous stem cells that display strong tissue protective and restorative properties by differentiating into cells of the mesodermal lineages. In addition to multi-lineage differentiation capacity, MSCs play important roles in regulating immune responses, inflammation, and tissue regeneration. MSCs play a role in the outcome of the pathogenesis of several infectious diseases. Read More

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Quantifying Bone Marrow Fat Fraction and Iron by MRI for Distinguishing Aplastic Anemia from Myelodysplastic Syndromes.

J Magn Reson Imaging 2021 Jun 11. Epub 2021 Jun 11.

Radiology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Background: Bone marrow of patients with aplastic anemia (AA) is different from that of patients with myelodysplastic syndrome (MDS) and is difficult to identify by blood examination. IDEAL-IQ (iterative decomposition of water and fat with echo asymmetry and least-squares estimation) imaging might be able to quantify fat fraction (FF) and iron content in bone tissues.

Purpose: To determine if IDEAL-IQ measurements of bone marrow FF and iron content can distinguish between patients with AA and MDS. Read More

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Atrial fibrillation is a predictor of nonobstructive coronary artery disease in elective angiography in old age: a cross-sectional study in Poland and Russia.

Aging Clin Exp Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiology, Medical University of Bialystok, M. Sklodowska-Curie Str. 24A, 15-276, Bialystok, Poland.

Background: Significant changes in the coronary vessels are not confirmed in a large proportion of patients undergoing cardiac catheterization.

Aims: The present study aimed to determine correlates and independent predictors of nonobstructive coronary artery disease (CAD) in older adults referred for elective coronary angiography.

Methods: A cross-sectional study was conducted involving 2,214 patients referred to two medical centers (in Poland and Russia) between 2014 and 2016 for elective coronary angiography due to exacerbated angina, despite undergoing optimal therapy for CAD. Read More

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Perioperative management of a patient undergoing resection of interleukin-6 producing pheochromocytoma.

JA Clin Rep 2021 Jun 11;7(1):49. Epub 2021 Jun 11.

Department of Anesthesiology, Yamagata University Hospital, 2-2-2 Iida-nishi, Yamagata City, Yamagata, 990-9585, Japan.

Background: Pheochromocytomas produce hormones, cytokines, and catecholamines. We report perioperative anesthetic management of a rare interleukin-6 (IL-6)-producing pheochromocytoma.

Case Presentation: A 32-year-old female was scheduled for laparoscopic adrenalectomy for pheochromocytoma. Read More

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Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress.

Nat Struct Mol Biol 2021 Jun 10;28(6):487-500. Epub 2021 Jun 10.

State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.

Fanconi anemia (FA) is a devastating hereditary disease characterized by bone marrow failure (BMF) and acute myeloid leukemia (AML). As FA-deficient cells are hypersensitive to DNA interstrand crosslinks (ICLs), ICLs are widely assumed to be the lesions responsible for FA symptoms. Here, we show that FA-mutated cells are hypersensitive to persistent replication stress and that FA proteins play a role in the break-induced-replication (BIR)-like pathway for fork restart. Read More

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Oncostatin-M Does Not Predict Treatment Response in Inflammatory Bowel Disease in a Pediatric Cohort.

J Pediatr Gastroenterol Nutr 2021 Jun 10. Epub 2021 Jun 10.

Divisions of Pediatric Gastroenterology Pathology Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA Division of Pediatric Gastroenterology, Inova Children's Hospital, Fairfax, VA, USA Division of Pediatric Gastroenterology, Pediatric Specialists of Virginia, Fairfax, VA, USA.

Objectives: This study aimed to determine whether mRNA expression of oncostatin-M (OSM) and its receptor (OSMR) in initial, pre-treatment intestinal biopsies is predictive of response to tumor necrosis factor antagonists (antiTNF) in a pediatric inflammatory bowel disease (IBD) cohort. Secondary outcomes correlated OSM and OSMR expression with demographic variables; IBD type, extent, phenotype, and severity; laboratory values; and endoscopic findings.

Methods: A retrospective chart review was conducted on 98 pediatric patients. Read More

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A European Survey on Digestive Perianastomotic Ulcerations, a Rare Crohn-Like Disorder Occurring in Children and Young Adults.

J Pediatr Gastroenterol Nutr 2021 Jun 10. Epub 2021 Jun 10.

Department of pediatric surgery, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Paris, France Children's Hospital, Zagreb University Medical School, Zagreb, Croatia Centre Hospitalier Universitaire de Saint Etienne, Saint Etienne, France Division of Gastroenterology and Hepatology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany Department of Paediatrics, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland Hôpital Timone Enfants, service de pédiatrie multidisciplinaire, Marseille, France Aix Marseille Univ, INSERM, MMG, Marseille, France Department of pediatric gastroenterology and nutrition, Hopital Robert Debré, Assistance Publique Hopitaux de Paris, Paris, France Université de Paris ; INSERM UMR1149 ; Paris, France Unidade de Gastrenterologia Pediátrica, Centro Hospitalar do Porto, Porto, Portugal Bordeaux University Hospital, Paediatric Gastroenterology Unit, CIC 1401, F-33000, Bordeaux, France Department of pediatric gastroenterology and nutrition, Hôpital Trousseau, Assistance Publique-Hopitaux de Paris, Paris, France Children's Hospital, University of Helsinki, Helsinki, Finland Centre Hospitalier Lyon Sud, Pierre Bénite, France Pediatric gastroenterology Unit, Ospedale Maggiore Carlo Alberto Pizzardi di Bologna, Bologna, Italy Sapienza University - Umberto I Hospital, Rome, Italy Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples, Italy Department of pediatrics, Hospices Civils de Lyon, Lyon, France. University Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France Department of pediatrics. Centre Hospitalier universitaire de Limoges, Limoges, France Department of pediatrics. Centre Hospitalier Universitaire Clocheville, Tours, France Department of pediatrics. University Normandie, UNICAEN, CHU de Caen Normandie, F-14000 Caen, France INSERM UMR 1073, University Rouen, F-76000 Rouen, France Al Jalila Children's Specialty Hospital, Dubai, United Arab Emirates Shaare Zedek Medical Center, Jerusalem, Jerusalem, Israel.

Objectives: Digestive perianastomotic ulcerations (DPAU) resembling Crohn's disease lesions are long-term complications of intestinal resections, occurring in children and young adults. They are known to be uncommon, severe and difficult to treat.

Methods: In the absence of recommendations, we performed a large European survey among the members of the ESPGHAN working group on inflammatory bowel disease (IBD) in order to collect the experience of expert pediatric gastroenterologists on DPAU. Read More

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