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Ann Intern Med 2019 03;170(6):OC1

Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey (J.L.C.).

PLoS One 2019 18;14(3):e0212817. Epub 2019 Mar 18.

Faculty of Health Sciences, University of Brasilia, Brasília, Distrito Federal, Brazil.

Objective: To investigate the association between maternal anemia and low/insufficient birth weight.

Design: A prospective cohort study of pregnant women who underwent prenatal care at the healthcare units in a municipality of northeast Brazil together with their newborn infants was carried out. The pregnant women were classified as having anemia when the hemoglobin level was below 11 g/dl. Read More

Ecotoxicol Environ Saf 2019 Mar 15;175:48-57. Epub 2019 Mar 15.

Hellenic Centre for Marine Research, Institute of Marine Biological Resources and Inland Waters, Anavissos, 19013 Attica, Greece.

Olive oil production generates large volumes of wastewaters mostly in peri-Mediterranean countries with adverse impacts on the biota of the receiving aquatic systems. Few studies have however documented its toxicity on aquatic species, with an almost total lack of relative studies on fish. We assessed the acute and sub-chronic OMW toxicity, as well as the acute and sub-chronic behavioural, morphological and biochemical effects of OMW exposure on the mosquitofish Gambusia holbrooki. Read More

Catheter Cardiovasc Interv 2019 Mar 18. Epub 2019 Mar 18.

Department of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas.

Cardiopulmonary resuscitation (CPR) is essential for the survival of cardiac arrest patients. High-quality chest compressions are critical for survival, but energetic resuscitation efforts can lead to chest injuries. Internal mammary artery (IMA) injury is a rare complication of CPR, but can lead to life-threatening intrathoracic hemorrhage. Read More

J Vet Intern Med 2019 Mar 18. Epub 2019 Mar 18.

Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.

Background: Copper-associated hepatopathy (CAH) is a common cause of liver disease in dogs. Although d-penicillamine can be an effective treatment, some dogs fail treatment or develop adverse effects. Ammonium tetrathiomolybdate (TTM) has been used to treat pathologic copper accumulation in other species, but its therapeutic potential for CAH is unknown. Read More

Ann N Y Acad Sci 2019 Mar 18. Epub 2019 Mar 18.

Division of Food Security and Agriculture, RTI International, Washington DC.

Here, we analyzed four population-based demographic and health surveys conducted in Bolivia between 1998 and 2016 to understand trends in anemia in children from 6 to 59 months of age by selected sociodemographic characteristics and three categories of altitude: low, medium, and high. Over the 18-year period, the prevalence of anemia was virtually unchanged while that in children living at high altitude increased. Anemia in children living at all three altitude categories is more than 40% and a severe public health problem according to the World Health Organization. Read More

Cancer Biomark 2019 Mar 6. Epub 2019 Mar 6.

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Multiple myeloma (MM) is a common hematological malignancy that is often associated with osteolytic lesions, anemia and renal impairment. Deregulation of miRNA has been implicated in the pathogenesis of MM. It was found in our study that miR-19b and miR-20a as members of crucial oncogene miR-17-92 cluster were differentially expressed between patients with MM and normal controls by genechip microarray, and this result was further confirmed in sera of patients with MM by qRT-PCR. Read More

Dig Endosc 2019 Mar 18. Epub 2019 Mar 18.

Digestive Endoscopy and Gastroenterology Unit, "ASST di Cremona", Cremona, Italy.

A 85 yo female with severe dilatative cardiomiopathy underwent to gastroscopy for anemia (Hb 6.4 g/dl) and melaena, founding a bleeding submucosal gastric mass of 15 mm in size (Fig 1a). We performed a temporary hemostasis with epinephrine and Argon Plasma Coagulation and the contrast-enhncement CT-scan showed rapid wash in of the mass, as in presence of rich vascularization (Fig 1b). Read More

Transfusion 2019 Mar 18. Epub 2019 Mar 18.

Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Background: Patients with cancer or other diagnoses associated with chronic anemia often receive red blood cell (RBC) transfusion as outpatients, but the effect of transfusion on functional status is not well demonstrated.

Study Design And Methods: To estimate the effect of transfusion on functional status and quality of life, we measured 6-minute walk test distance and fatigue- and dyspnea-related quality-of-life scores before and 1 week after RBC transfusion in 208 outpatients age ≥50 with at least one benign or malignant hematology/oncology diagnosis. To account for potential confounding effects of cancer treatment, patients were classified into two groups based on cancer treatment within 4 weeks of the study transfusion. Read More

Cochrane Database Syst Rev 2019 Mar 16;3:CD012064. Epub 2019 Mar 16.

Department of Pediatric Hematology and Oncology, National Institute of Blood Disease & Bone Marrow Transplant, ST 2/A Block 17 Gulshan-e-Iqbal, KDA Scheme 24, Karachi, Sindh, Pakistan, 75300.

Background: Hydroxyurea (hydroxycarbamide) promotes the production of foetal haemoglobin (HbF) by reactivating gamma-genes. Evidence has shown clinical benefits of hydroxyurea in people with sickle cell anemia; however, only a few studies have assessed this treatment in people with beta (β)-thalassaemia.

Objectives: The primary objective is to review the efficacy of hydroxyurea in reducing or ameliorating the requirement of blood transfusions in people with transfusion-dependent β-thalassaemia. Read More

Medicine (Baltimore) 2019 Mar;98(11):e14882

Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University.

Surgical site infections (SSI) are devastating complications after surgery for femoral neck fractures. There are a lot of literature have shown a strong association between diabetic patients and SSI. This study aimed to identify diabetes as an independent risk factor of SSI, focusing on femoral neck fractures, and to investigate the other potential risk factors for SSI. Read More

Medicine (Baltimore) 2019 Mar;98(11):e14870

Department of Pediatrics, Kangwon National University School of Medicine, Chuncheon, Republic of Korea.

Rationale: Collagenous gastritis (CG) is a rare form of chronic gastritis defined histologically by a thickened subepithelial collageneous band in the lamina propria. However, the clinical features and endoscopic findings of CG have not been clearly established in the pediatric population.

Presenting Concerns: We report the cases of 3 children who presented with intractable anemia and minimal or no gastrointestinal (GI) symptoms and were followed up without definitive diagnosis determination even through diagnostic endoscopic evaluations. Read More

Hosp Pract (1995) 2019 Mar 18:1-3. Epub 2019 Mar 18.

d Department of Pharmacy , Western Hospital , Melbourne , Australia.

Objectives: Iron polymaltose infusions are one type of iron infusate used to treat iron deficiency used in countries such as Australia. We looked at the safety profile of this infusion at one metropolitan hospital in Melbourne, Australia and the associated demographics of those who had reactions.

Methods: A retrospective review of the medical records all adult patients who had an iron polymaltose infusion at Western Hospital over 12 months was performed. Read More

Am J Clin Nutr 2019 Mar 18. Epub 2019 Mar 18.

Hubert Department of Global Health, Emory University, Atlanta, GA.

Background: In India, the prevalences of stunting and anemia have declined in the last decade, but continue to remain high in many regions, whereas those of overweight and obesity have increased in all age and socioeconomic groups. Determining whether these forms of malnutrition cluster is important for the development of appropriate interventions.

Objectives: Our objective was to describe the prevalence of a comprehensive list of dual burdens of malnutrition in individuals and households across the 36 states and 640 districts of India. Read More

Annu Rev Cancer Biol 2019 Mar 3;3:457-478. Epub 2018 Dec 3.

Department of Radiation Oncology and Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA;

Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure (BMF), congenital defects, inability to repair DNA interstrand cross-links (ICLs), and cancer predisposition. FA presents two seemingly opposite characteristics: () massive cell death of the hematopoietic stem and progenitor cell (HSPC) compartment due to extensive genomic instability, leading to BMF, and () uncontrolled cell proliferation leading to FA-associated malignancies. The canonical function of the FA proteins is to collaborate with several other DNA repair proteins to eliminate clastogenic (chromosome-breaking) effects of DNA ICLs. Read More

Transl Pediatr 2019 Jan;8(1):28-34

Department of Gastroenterology, Queensland Children's Hospital, South Brisbane, Queensland, Australia.

Background: Iron deficiency (ID) with or without anemia is a common complication of pediatric inflammatory bowel disease (IBD), causing significant morbidity. Despite this, ID remains prevalent and undertreated, related in part to questions surrounding optimal formulation and route of administration. Ferric carboxymaltose (FCM) is a recent formulation of intravenous iron, allowing higher doses and rapid infusion times. Read More

Cardiovasc Diagn Ther 2019 Feb;9(1):68-72

Instituto Nacional de Saúde, Maputo, Mozambique.

Unacceptably high incidence of pediatric HIV despite worldwide increased access to antiretroviral therapy. The routine management of these children includes provision of antiretroviral therapy, and periodic assessment of its results and complications. However, no systematic assessment of the nutritional status, lipid profile or screening for cardiovascular disease is done. Read More

Case Rep Gastrointest Med 2019 6;2019:4526472. Epub 2019 Feb 6.

Department of Gastroenterology, Hamad Medical Corporation, Doha, Qatar.

Ectopic varices are portosystemic collaterals that occur away from the gastroesophageal junction and account for 1-5% of all variceal bleeding. Its occurrence in the jejunum is rare. Most common cause of ectopic jejunal varices is portal hypertension especially in those patients who have undergone prior abdominal surgery. Read More

J Parasitol Res 2019 6;2019:8528430. Epub 2019 Feb 6.

Grupo de Inmunobiología, Centro de Estudios Biomédicos y Veterinarios, Universidad Nacional Experimental Simón Rodríguez-IDECYT, Caracas, Venezuela.

There are three trypanosoma species of veterinary importance in South America: (1) the causative agent of derrengadera mechanically transmitted by bloodsucking insects such as tabanids, (2) , also mechanically transmitted by some dipteras hematophages as tabanids and/or and (3) a tissue parasite adapted to sexual transmission and the causative agent of dourine, a distinctive disease that affects only Equidae. In order to evaluate the parasitological, hematological, and serological response of sheep infected with , , and , four female sheep were experimentally infected with Venezuelan trypanosome field isolates: two of differing virulences, one ; one . Parasitemia and clinical parameters such as hematocrit, red blood cell count, hemoglobin, and body temperature were measured. Read More

Oncol Lett 2019 Apr 18;17(4):3687-3700. Epub 2019 Feb 18.

Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Fanconi anemia group D2 protein (FANCD2) and breast cancer type 1 susceptibility protein (BRCA1), within the FA/BRCA pathway, are involved in the regulation of DNA damage repair, which is associated with breast cancer (BC) progression. The present study aimed to investigate BRCA1 and FANCD2 expression in breast cancer, and to highlight the association with patient clinical characteristics and prognoses. The BRCA1 and FANCD2 proteins were detected by immunohistochemistry in 335 tissue samples obtained from patients with BC, including 141 patients with familial BC (FBC), 147 patients with sporadic breast cancer (SBC) and 47 patients with benign breast tumors. Read More

Pak J Med Sci 2019 Jan-Feb;35(1):82-85

Dr. Gulden Sincan, Department of Hematology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.

Objective: We aimed to compare laboratory features, histopathological types, response to treatment of patients with non hodgkin lymphoma in our department and other regions.

Methods: A total of 80 patients nonhodgkin lymphoma were evaluated. Because we had only 80 patients with complete data, we used T test for comparison of groups. Read More

Pak J Med Sci 2019 Jan-Feb;35(1):61-65

Dr. Neelam Siddiqui, MRCP, FRCP, CCST (Medical Oncology), Consultant Oncologist, Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Objective: Purpose of this study was to find out frequency of anemia and its causes in newly diagnosed treatment naive lymphoma patients.

Methods: We retrospectively studied all lymphoma patients (> 18 years age) diagnosed and treated at Shaukat Khanum Memorial Cancer Hospital and Research Centre, from January 2016 till January 2017. The data was collected from electronic Hospital Information System. Read More

EJIFCC 2019 Mar 1;30(1):99-105. Epub 2019 Mar 1.

Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.

A 28-year-old male with acute on chronic liver failure (ACLF) and hepatic encephalopathy had deranged liver function with curiously low level (0-15 IU/L) of serum alkaline phosphatase (ALP). Peripheral smear examination suggested hemolytic anemia. The finding of persistent low ALP, after ruling out pre-analytical causes, in ACLF has been reported in Wilson's disease (WD) with/ without autoimmune hemolytic anemia (AIHA). Read More

EJIFCC 2019 Mar 1;30(1):67-81. Epub 2019 Mar 1.

Department of Hematology & Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Ethiopia.

Diamond Blackfan Anaemia (DBA) is a sporadic inherited anemia with broad spectrum of anomalies that are presented soon after delivery. It is inherited mainly in autosomal dominant inheritance manner and caused by mutations and deletions in either large or small ribosomal protein genes that results in an imbalance between the biosynthesis of rRNA and ribosomal proteins, eventually the activation and stabilization of p53. Diagnosing DBA is usually problematic due to a partial phenotype and its wide inconsistency in its clinical expression; however, molecular studies have identified a heterozygous mutated gene in up to 50% of the DBA cases and corticosteroid drugs are the backbone treatment options of DBA. Read More

EJIFCC 2019 Mar 1;30(1):35-47. Epub 2019 Mar 1.

Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Ethiopia.

Background: Anemia in children continues to be a major public health challenge in most developing countries, particularly in Africa.In the early stages of life, it leads to severe negative consequences on the cognitive functions as well as growth and development of the children, which may persist even after treatment.

Objective: The main aim of this study was to assess the prevalence and associated factors of anemia among hospitalized children attending at university of Gondar comprehensive and specialized referral hospital, Northwest Ethiopia. Read More

Infect Drug Resist 2019 5;12:521-527. Epub 2019 Mar 5.

School of Medicine, Department of Medical Laboratory Science, College of Health Science and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

Background: Malaria is a major health problem in the tropics, with 300-500 million cases and 1.1-2.7 million deaths occurring annually. Read More

Onco Targets Ther 2019 28;12:1681-1689. Epub 2019 Feb 28.

Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong 250117, China,

Purpose: The aim of this study was to assess the efficacy and safety of concurrent apatinib and docetaxel therapy vs apatinib monotherapy as third- or subsequent-line treatment for advanced gastric adenocarcinoma (GAC).

Methods: Patients, who had received apatinib with or without docetaxel as third or more line therapy for advanced GAC, were retrospectively reviewed. Propensity score matching (PSM) analysis was performed to minimize the potential confounding bias. Read More

Indian J Public Health 2019 Jan-Mar;63(1):79-82

Professor, Centre of Food Technology, University of Allahabad, Allahabad, Uttar Pradesh, India.

Anemia and zinc deficiency are two of the most daunting nutritional problems afflicting the young children among developing countries like India. Thus, in view of this the following study was designed to investigate the status of undernutrition and micronutrient status (iron and zinc) of children aged between 4 and 6 years of Allahabad district. The anthropometric measurements (height and weight); biochemical parameters (hemoglobin and serum zinc), and general information of the children were recorded. Read More

Indian J Public Health 2019 Jan-Mar;63(1):58-64

Professor and Head, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.

Background: Salt fortification with iron is a potential strategy to increase population-level iron intake. The current evidence regarding double-fortified salt (DFS) in improving iron nutrition status is equivocal.

Objective: To study the efficacy of DFS as compared to iodine fortified salt (IS) in improving iron nutrition status. Read More

Hematology 2019 Dec;24(1):355-361

a Department of Hematology and Hematopoietic Stem Cell Transplantation , Yamanashi Prefectural Central Hospital , Kofu , Japan.

Objectives: To explore real-world prognoses for tyrosine kinase inhibitor (TKI) discontinuation in chronic myeloid leukemia (CML) patients and the associated reasons for TKI discontinuation.

Methods: We investigated, using the medical records of 85 consecutive CML patients who received TKIs between December 2001 and August 2016 at our hospital, reasons for discontinuation, duration of TKI treatment before discontinuation, molecular response (MR) status at TKI discontinuation, treatment-free remission (TFR) duration, and overall survival after TKI discontinuation.

Results: TKI therapy was discontinued in 21 patients. Read More

Toxicol Appl Pharmacol 2019 Mar 14. Epub 2019 Mar 14.

Division of Hematology/Oncology, Department of Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States; Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, United States. Electronic address:

N,N-Diethyl-3-methylbenzamide (DEET) is the most widely used insect repellent in the world. Adverse effects following DEET exposure are well documented. Moreover, DEET has been shown to possess cytotoxic and apoptotic properties in nucleated cells. Read More

Transplant Proc 2019 Mar 28;51(2):376-379. Epub 2018 Oct 28.

Section of Pulmonary Medicine, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.

Background: Hepatitis E virus (HEV) is one of the common causes of acute and chronic viral hepatitis with a global distribution. Genotypes 1 and 2 only affect humans and produce acute hepatitis epidemics in endemic regions (Asia, Africa). In nonendemic areas (America, Europe), genotypes 3 and 4 are considered a zoonosis and cause sporadic acute hepatitis. Read More

Acta Virol 2019 ;63(1):19-25

Chicken infectious anemia (CIA) is an immunosuppressive disease that causes great economic loss in poultry industry globally. This disease is caused by chicken anemia virus (CAV), an icosahedral and single-stranded DNA virus that is transmitted both vertically and horizontally. CAV, which belongs to the genus Gyrovirus has been reported in human, mouse and dog feces. Read More

Korean J Intern Med 2019 Mar 19. Epub 2019 Mar 19.

Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.

Background/aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and safety of SOF/RBV in Korean patients with HCV GT2 infection and clinical factors predicting sustained virological response 12 weeks (SVR12) after the end of SOF/RBV treatment.

Methods: A total of 181 patients with HCV GT2 with/without cirrhosis were treated with SOF/RBV for 16/12 weeks. Read More

Dig Dis Sci 2019 Mar 16. Epub 2019 Mar 16.

Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX, 77030, USA.

Background: Anemia is a common complication of inflammatory bowel disease (IBD). Despite existing guidelines for anemia in IBD, it is frequently under-treated and the prevalence of anemia has remained high. To address this gap, the Crohn's and Colitis Foundation developed the Anemia Care Pathway (ACP). Read More

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

US Air Force Hospital Keesler AFB, Keesler AFB, Mississippi, USA.

Lanthanum carbonate is a phosphate binder that is used to reduce serum phosphate levels in patients with end-stage renal disease (ESRD). Lanthanum forms insoluble lanthanum phosphate complexes that are supposed to pass through the gastrointestinal (GI) tract unabsorbed. Phosphate binders have been reported to deposit in the GI tract and can cause mucosal injury. Read More

Clin Chim Acta 2019 Mar 13. Epub 2019 Mar 13.

First Department of Propaedeutic Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Aims: To investigate the effect of heterozygous β-thalassemia on HbA1c levels in a population without diabetes mellitus (DM).

Methods: Using a cross-sectional design, HbA1c levels were compared between two groups of 100 consecutive carriers of β-thalassemia and 100 healthy controls matched for age, gender and BMI, taking into account fasting serum glucose and fructosamine levels. The effect of hemoglobin concentration on HbA1c was also examined. Read More

Cell Syst 2019 Mar 11. Epub 2019 Mar 11.

Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Graduate Program in Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

Systems biology requires not only genome-scale data but also methods to integrate these data into interpretable models. Previously, we developed approaches that organize omics data into a structured hierarchy of cellular components and pathways, called a "data-driven ontology." Such hierarchies recapitulate known cellular subsystems and discover new ones. Read More

Crit Rev Oncol Hematol 2019 Apr 15;136:37-47. Epub 2019 Feb 15.

Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland; Department for BioMedical Research, University of Bern, Switzerland. Electronic address:

Anemic patients with lower risk myelodysplastic syndromes are frequently treated with erythropoiesis stimulating agents (ESA), eventually in combination with granulocyte colony stimulating factor (G-CSF). However, the evidence for the efficacy of a combined treatment remains controversial. The goal of our analysis was to assess the available evidence for a combined treatment. Read More

Aging Clin Exp Res 2019 Mar 14. Epub 2019 Mar 14.

The Department of Family Medicine, MacKay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Zhongshan Dist., Taipei, 104, Taiwan, ROC.

Background: Pneumonia is a leading cause of hospitalization and death worldwide. However, studies focusing on risk factors of community-acquired pneumonia (CAP) in the home health care (HHC) population remain scarce.

Aims: This study aimed to evaluate risk factors associated with hospitalization for CAP among HHC patients in Taiwan. Read More

J Allergy Clin Immunol Pract 2019 Mar 12. Epub 2019 Mar 12.

Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA, USA. Electronic address:

Background: While autoimmunity and hyperinflammation secondary to recombinase activating gene (RAG) deficiency have been associated with delayed diagnosis and even death, our current understanding is limited primarily to small case series.

Objective: Understand the frequency, severity, and treatment responsiveness of autoimmunity and hyperinflammation in RAG deficiency.

Methods: In reviewing the literature and our own database, we identified 85 patients with RAG deficiency, reported between 2001 and 2016, and compiled the largest case series to date of 63 patients with prominent autoimmune and/or hyperinflammatory pathology. Read More

Ticks Tick Borne Dis 2019 Mar 8. Epub 2019 Mar 8.

Universidade Católica Dom Bosco (UCDB), Avenida Tamandaré, 6000, Campo Grande, MS, Brazil. Electronic address:

Brazilian Pantanal is the world´s largest wetland ecosystem, where cattle's ranching is the most important economic activity. The objective of this study was to compile some epidemiological features on equine piroplasmids from the Nhecolândia sub-region of Pantanal wetland through the evaluation of the patterns of T. equi and B. Read More

Exp Hematol 2019 Mar 12. Epub 2019 Mar 12.

Project Division of ALA Advanced Medical Research, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan; Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, Fukuoka, Japan. Electronic address:

Krüppel-like factor 1 (KLF1), a transcription factor controlling definitive erythropoiesis, is involved in sequential control of terminal cell division and enucleation via fine regulation of key cell-cycle regulator genes expression in erythroid lineage cells. Type IV congenital dyserythropoietic anemia (CDA) is caused by a monoallelic mutation at the second zinc finger of KLF1 (c.973G>A; p. Read More

Lancet 2019 Mar 8. Epub 2019 Mar 8.

Murdoch Children's Research Institute, Melbourne, VIC, Australia; Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Centre for Adolescent Health, Royal Children's Hospital, Parkville, VIC, Australia.

Background: Rapid demographic, epidemiological, and nutritional transitons have brought a pressing need to track progress in adolescent health. Here, we present country-level estimates of 12 headline indicators from the Lancet Commission on adolescent health and wellbeing, from 1990 to 2016.

Methods: Indicators included those of health outcomes (disability-adjusted life-years [DALYs] due to communicable, maternal, and nutritional diseases; injuries; and non-communicable diseases); health risks (tobacco smoking, binge drinking, overweight, and anaemia); and social determinants of health (adolescent fertility; completion of secondary education; not in education, employment, or training [NEET]; child marriage; and demand for contraception satisfied with modern methods). Read More

Nutrients 2019 Mar 15;11(3). Epub 2019 Mar 15.

Department of Physiology (Faculty of Pharmacy, Campus Universitario de Cartuja) and Institute of Nutrition and Food Technology "José Mataix", University of Granada, E-18071 Granada, Spain.

Although dietary iron is a determinant of iron status in animals, body fat mass has been reported to have an inverse association with iron status in human studies. The goal of this study was to determine the relationship between Fe homeostasis, body composition, energy expenditure and neuroendocrine regulators for severe Fe-deficiency anaemia. Forty male Wistar albino rats recently weaned were divided at random into two groups: the control group was fed the basal diet, AIN-93G diet (normal-Fe) and the anaemic group received a low-Fe diet for 40 days. Read More

J Neurosurg 2019 Mar 15:1-10. Epub 2019 Mar 15.

OBJECTIVEThe complex decision analysis of unruptured intracranial aneurysms entails weighing the benefits of aneurysm repair against operative risk. The goal of the present analysis was to build and validate a predictive scale that identifies patients with the greatest odds of a postsurgical adverse event.METHODSData on patients who underwent surgical clipping of an unruptured aneurysm were extracted from the prospective National Surgical Quality Improvement Program registry (NSQIP; 2007-2014); NSQIP does not systematically collect data on patients undergoing intracranial endovascular intervention. Read More

DNA Repair (Amst) 2019 Feb 27;77:36-44. Epub 2019 Feb 27.

Graduate Field of Biochemistry, Molecular and Cellular Biology, Cornell University, Ithaca, NY, 14853, USA; Division of Nutritional Sciences, Cornell University, 127 Savage Hall, Ithaca, NY, 14853, USA. Electronic address:

Genomic instability is implicated in the etiology of several deleterious health outcomes including megaloblastic anemia, neural tube defects, and neurodegeneration. Uracil misincorporation and its repair are known to cause genomic instability by inducing DNA strand breaks leading to apoptosis, but there is emerging evidence that uracil incorporation may also result in broader modifications of gene expression, including: changes in transcriptional stalling, strand break-mediated transcriptional upregulation, and direct promoter inhibition. The factors that influence uracil levels in DNA are cytosine deamination, de novo thymidylate (dTMP) biosynthesis, salvage dTMP biosynthesis, dUTPase, and DNA repair. Read More

Int J Clin Oncol 2019 Mar 14. Epub 2019 Mar 14.

Division of Breast and Medical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, Japan.

Background: Radium-223 is a first-in-class targeted alpha therapy to prolong overall survival (OS) in castration-resistant prostate cancer with bone metastases (mCRPC). The aim of the present analysis was to assess the long-term safety with radium-223 in Japanese patients with mCRPC.

Methods: Patients with symptomatic mCRPC, ≥ 2 bone metastases and no known visceral metastases received up to 6 injections of radium-223 (55 kBq/kg), one every 4 weeks. Read More

Arch Rheumatol 2018 Dec 23;33(4):473-477. Epub 2018 Mar 23.

Department of Pediatric Surgery, Ege University School of Medicine, İzmir, Turkey.

Symptoms of infantile inflammatory bowel disease (I-IBD) can be life-threatening and associated with poor prognosis. The presence of Mediterranean fever (MEFV) gene mutations play an important role in treatment of I-IBD. In this article, we describe a case of I-IBD with a resistant fistula, in which remission occurred following colchicine therapy. Read More

Arch Rheumatol 2018 Dec 23;33(4):455-463. Epub 2018 Mar 23.

Department of Medicine, The University of Jordan, Amman, Jordan.

Objectives: This study aims to describe the clinical and immunological characteristics of systemic lupus erythematosus in the Arab world.

Materials And Methods: We searched PubMed and Google Scholar for observational studies describing the clinical and serologic features of systemic lupus erythematosus in adult patients in the Arab world. We used the search terms "lupus in Arabs" and the names of individual Arab countries. Read More