245,467 results match your criteria Anemia

Methodologies and tools to shed light on erythrophagocytosis.

Biochimie 2022 Aug 8. Epub 2022 Aug 8.

Université de La Réunion, INSERM, UMR 1188 Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), Saint-Denis de La Réunion, France. Electronic address:

Red blood cells (RBC) are the most abundant circulating cell of the human body. RBC are constantly exposed to multiple stresses in the circulation, leading to molecular and structural impairments and death. The physiological process of RBC senescence or ageing is referred to as eryptosis. Read More

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Sodium-glucose co-transporter 2 inhibitors and hematopoiesis.

J Cell Physiol 2022 Aug 11. Epub 2022 Aug 11.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Many patients with diabetes mellitus, especially those with chronic kidney disorders, have some degree of anemia due to a spectrum of causes and underlying pathophysiologic pathways. As such, enhancement in erythropoiesis is important in these patients. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a relatively new class of antidiabetic drugs with confirmed protective effects in kidney and cardiovascular tissues. Read More

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Low mean HbA1c does not increase all-cause and cardiovascular mortality in patients with diabetes: Effect-modifications by anemia and chronic kidney disease stages.

PLoS One 2022 11;17(8):e0272137. Epub 2022 Aug 11.

Department of Endocrinology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

Background: Previous studies reported that low levels of glycated hemoglobin A1c (HbA1c) were associated with increased mortality. We investigated rates and risks of all-cause and cardiovascular mortality in association with mean HbA1c levels with stratification of anemia and chronic kidney disease (CKD) stages, major causes of low HbA1c.

Methods: 47,145 patients with prescription of antidiabetic agents >6 months in the outpatient visits (2003-2018) were linked to Taiwan's National Death Registry to identify all-cause and cardiovascular mortality. Read More

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Clinical Diagnosis and Therapeutic Management of Trypanosoma theileri Infection Associated with Peritonitis in Crossbred Cow: A Rare Case Report.

Acta Parasitol 2022 Aug 11. Epub 2022 Aug 11.

Veterinary Diagnostic Laboratory, Department of Veterinary Clinical Complex, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, 125004, India.

Purpose: The present study reports a very rare case of Trypanosoma theileri like infection in the peritoneal fluid of a 6-year-old female Holstein Friesian (HF) cattle brought to Veterinary Clinical Complex, Lala Lajpat Rai University of Veterinary and Animal Sciences (LUVAS), Hisar. The aim of the clinical study was to report an unusual case of T. theileri-like infection associated with peritonitis and its therapeutic management. Read More

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Gastrointestinal symptoms and endoscopy findings after pediatric solid organ transplantation: A case series.

Pediatr Transplant 2022 Aug 11:e14374. Epub 2022 Aug 11.

Department of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.

Background: Gastrointestinal symptoms are common among solid organ transplant (SOT) recipients. Information about colonoscopy findings after pediatric SOT is limited. This retrospective study reports endoscopy findings in a nationwide pediatric transplant recipient cohort. Read More

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Hb Wanjiang: A New β-Globin Chain Variant with Two Amino Acid Substitutions (: c.255_264delinsTTTTTCTCAG).

Hemoglobin 2022 Aug 11:1-3. Epub 2022 Aug 11.

Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou, People's Republic of China.

We report a new hemoglobin (Hb) variant that we have named Hb Wanjiang (: c.255_264delinsTTTTTCTCAG). We identified this variant in a Chinese man by the next-generation sequencing (NGS) method. Read More

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Clinical Severity of β-Thalassemia Pediatric Patients in Myanmar.

Hemoglobin 2022 Jan;46(1):66-70

Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.

β-Thalassemia (β-thal) is highly prevalent in Myanmar, but limited data are available on the molecular basis and the clinical manifestations in Myanmar patients. In this study, we investigated the clinical features and β-globin gene abnormalities in 15 homozygous β-thal and 60 Hb E (: c.79G>A)/β-thal pediatric patients who attended Yangon Children Hospital, the biggest thalassemia day care unit center in Myanmar. Read More

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January 2022

Efficacy of Extract on Chemotherapy-Related Tasted Disorders in Pancreatic Cancer Patients.

Nutr Cancer 2022 Aug 11:1-11. Epub 2022 Aug 11.

Department of Surgery, Kansai Medical University, Hirakata, Japan.

Patients undergoing chemotherapy suffer from taste disorders that affect the quality of life (QOL). In this study, a randomized, double-blind, placebo-controlled trial was conducted to explore the effectiveness of AHCC, a standardized extract of cultured , for chemotherapy-related adverse events and taste disorders in patients with gastrointestinal cancer. Patients who received chemotherapy were randomized to receive either placebo or AHCC. Read More

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Phase III MANIFEST-2: pelabresib + ruxolitinib vs placebo + ruxolitinib in JAK inhibitor treatment-naive myelofibrosis.

Future Oncol 2022 Aug 11. Epub 2022 Aug 11.

Division of Hematology and Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Myelofibrosis (MF) is a clonal myeloproliferative neoplasm, typically associated with disease-related symptoms, splenomegaly, cytopenias and bone marrow fibrosis. Patients experience a significant symptom burden and a reduced life expectancy. Patients with MF receive ruxolitinib as the current standard of care, but the depth and durability of responses and the percentage of patients achieving clinical outcome measures are limited; thus, a significant unmet medical need exists. Read More

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Quantification and influencing factors of perioperative hidden blood loss in patients undergoing laparoscopic ovarian cystectomy for benign ovarian tumours.

J Obstet Gynaecol 2022 Aug 11:1-6. Epub 2022 Aug 11.

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

This retrospective, monocentric study quantified hidden blood loss (HBL) and investigated its influencing factors in benign ovarian tumour patients undergoing laparoscopic ovarian cystectomy. Data from 153 patients who underwent laparoscopic ovarian cystectomy were retrospectively reviewed. HBL was calculated using the formula derived from 'Nadler' and 'Cross'. Read More

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Age-Dependent Hematologic Toxicity Profiles and Prognostic Serologic Markers in Postoperative Radiochemotherapy Treatment for Uterine Cervical Cancer.

Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221118188

Department of Radiation Oncology, 27178Heidelberg University Hospital, Heidelberg, Germany.

In the adjuvant setting for cervical cancer, classical risk factors for postoperative radiochemotherapy have been established. However, data on laboratory changes during therapy and the prognostic value of serological markers are limited and further knowledge is needed to optimize the toxic trimodal regimen. We retrospectively identified 69 women who underwent weekly postoperative radiochemotherapy with 40 mg/m of cisplatin for cervical cancer between 2010 and 2021 at a single center. Read More

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Pregnancy in the Sickle Cell Disease and Fetomaternal Outcomes in Different Sickle cell Genotypes: A Systematic Review and Meta-Analysis.

Ethiop J Health Sci 2022 Jul;32(4):849-864

Social Determinants in Health Promotion Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Background: Pregnancy is a major concern among women with the sickle cell disease (SCD), and it is associated with increased adverse outcomes. The aim of the present meta-analysis is to report the fetomaternal outcomes in different sickle cell genotypes.

Methods: In this systematic review and meta-analysis, a comprehensive search of databases and search engines such as PubMed, Scopus, Web of Science, ProQuest, Cochrane Library, Science Direct and Google Scholar were performed. Read More

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Spontaneous Twin Pregnancy: A Challenging and Exceptional Scenario in a Patient on Maintenance Hemodialysis in Sub-Saharan Africa.

Case Rep Nephrol Dial 2022 May-Aug;12(2):90-95. Epub 2022 Jun 7.

Nephrology Service, Yaounde General Hospital, Yaounde, Cameroon.

Chronic hemodialysis is associated with reduced fertility. Hence, pregnancy remains rare, challenging, and deleterious when unplanned, especially in low-resource countries. Contraception and births are very important in these settings. Read More

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Stem cells as an option for the treatment of COVID-19.

World J Clin Cases 2022 Jun;10(18):6338-6340

Institute of Biomedical Sciences, Autonomous University of Ciudad Juárez, Ciudad Juarez 32310, Chihuahua, Mexico.

The application of stem cells is among the many strategies currently available for the treatment of multiple diseases. Stem cells are characterized as undifferentiated cells that have the ability to differentiate towards multiple lineages and self-renewal, among other attributes. Since the first umbilical cord stem cell transplant for the treatment of Fanconi anemia, the use of stem cells for the treatment of multiple diseases, including coronavirus disease 2019, has increased, showing promising results that require evaluation through research studies that include a longer follow-up time. Read More

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Expression and prognostic potential of TMEM204: a pan-cancer analysis.

Int J Clin Exp Pathol 2022 15;15(7):258-271. Epub 2022 Jul 15.

Endoscopic Center, The Six Affiliated Hospital, South China University of Technology (People's Hospital of Nanhai District) Foshan 528200, Guangdong, China.

TMEM204 (Transmembrane Protein 204) is a member of the TMEM family that regulates cell function and angiogenesis. Previous studies showed that TMEM204 is related to pancreatic cancer, but its roles in other cancers remain unknown. To reveal this relationship, we conducted a pan-cancer analysis by several online databases. Read More

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Trametinib: Could It Be a Promising Drug to Treat Atypical Chronic Myeloid Leukemia?

Cureus 2022 Jul 6;14(7):e26619. Epub 2022 Jul 6.

Oncology, Saint Luke's Cancer Institute, University of Missouri Kansas City, Kansas City, USA.

Atypical chronic myeloid leukemia (aCML) is a rare disease that is currently classified under the myelodysplastic (MDS)/myeloproliferative neoplasm (MPN) disease spectrum. MDS/MPN diseases are characterized by the absence of the Philadelphia (Ph) chromosome and the overlap between bone marrow fibrosis and dysplastic features. The Ph chromosome, resulting from BCR-ABL1 translocation, helps to distinguish aCML from chronic myeloid leukemia (CML). Read More

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The Challenges in Diagnosis and Management of Acquired Thrombotic Thrombocytopenic Purpura: Consensus Report from Three Gulf Countries.

Oman Med J 2022 Jul 31;37(4):e407. Epub 2022 Jul 31.

Department of Hematology, Dubai Hospital, Dubai, UAE.

Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare hematological emergency characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, and multiorgan failure due to autoimmune-mediated deficiency in ADAMTS-13 activity. Currently, plasma exchange, with or without steroids, is the frontline option for the management of aTTP. The treatment should be started promptly once the disorder is clinically suspected. Read More

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Clinicopathological Profile of Paroxysmal Nocturnal Hemoglobinuria among Omani Patients: A Case Series.

Oman Med J 2022 Jul 31;37(4):e405. Epub 2022 Jul 31.

Department of Hematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

We aimed to estimate the nature and prevalence of paroxysmal nocturnal hemoglobinuria (PNH) among Omani patients. We performed a retrospective review of all patients who were tested for PNH by flow cytometry at the Sultan Qaboos University Hospital, Muscat, between 2012 and 2019. Manifestations, treatment modalities, and outcomes were assessed. Read More

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Novel SPTB frameshift mutation in a Chinese neonatal case of hereditary spherocytosis type 2: A case report.

Exp Ther Med 2022 Sep 28;24(3):600. Epub 2022 Jul 28.

Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Heifei, Anhui 230601, P.R. China.

Hereditary spherocytosis (HS) is an erythrocyte membrane disease with a non-specific phenotype, particularly occurring in neonatal patients, and its diagnosis is challenging. The present study reports on a patient with neonatal HS and reviewed the genetic characteristics of reported neonatal HS cases in China. The patient was admitted only a few hours after birth with jaundice. Read More

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September 2022

Gastric Tube Ulcer that Could Be Saved by Early Conservative Treatment.

Case Rep Gastroenterol 2022 May-Aug;16(2):357-361. Epub 2022 Jun 13.

Department of Gastrointesinal Surgery, The Jikei University School of Medicine, Tokyo, Japan.

The patient was an 81-year-old man who had received subtotal esophagectomy for esophageal cancer reconstructed by a gastric tube via a posterior mediastinal route. He presented to our emergency room with a complaint of epigastric pain and a small amount of hematemesis. Thoracoabdominal computed tomography showed that the reconstructed gastric tube was filled fluid and had irregular wall thickening. Read More

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Recurrent and Multiple Intracerebral Hemorrhages in Polycythemia Vera Secondary to Myelofibrosis: A Case Report and Literature Review.

Case Rep Neurol 2022 May-Aug;14(2):274-280. Epub 2022 Jun 7.

Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.

Polycythemia vera (PV) is one of the myeloproliferative neoplasms and has higher frequency of the V617F mutation. Hemorrhagic stroke is rare in PV, and myelofibrosis is secondary to PV. A 76-year-old Japanese man was diagnosed as PV with the V617F mutation at the age of 63 years. Read More

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A 75-Year-Old Female Smoker with Advanced Small-Cell Lung Cancer and Eastern Cooperative Oncology Group Performance Status 2 who Responded to Combination Immunochemotherapy with Atezolizumab, Etoposide, and Carboplatin.

Am J Case Rep 2022 Aug 11;23:e936536. Epub 2022 Aug 11.

Second Department of Lung Diseases and Tuberculosis, Medical University of Białystok, Białystok, Poland.

BACKGROUND Atezolizumab is an immune checkpoint inhibitor used as first-line treatment with carboplatin and etoposide chemotherapy for advanced small cell lung cancer. Immunochemotherapy treatment decisions can be affected by patients' physical ability. Because of the exclusion of patients with an Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≥2 from clinical trials, treatment outcome evidence in this group is limited. Read More

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Identifying Patients at Risk for Venous Thromboembolic Events After Isolated Upper Extremity Trauma: A Predictive Scale.

Orthopedics 2022 Aug 10:1-8. Epub 2022 Aug 10.

Previous studies have defined risk factors for development of venous thromboembolisms (VTEs) among patients with lower extremity orthopedic trauma. Limited data exist on this risk after upper extremity orthopedic trauma. A total of 269,137 incidents of upper extremity orthopedic trauma (fractures of the clavicle, scapula, humerus, elbow, or lower arm) were identified in the State Inpatient Database for 4 states included in the analysis (California, Florida, New York, and Washington) from 2006 to 2014. Read More

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A Systematic Review, Meta-Analysis, and Indirect Comparison of Blindly Adjudicated Cardiovascular Event Incidence with Ferric Derisomaltose, Ferric Carboxymaltose, and Iron Sucrose.

Adv Ther 2022 Aug 10. Epub 2022 Aug 10.

Department of Cardiology, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.

Introduction: Intravenous (IV) iron is the preferred treatment for patients with iron deficiency anemia (IDA) who require rapid replenishment of iron stores or in whom oral iron is not tolerated or effective. Data from two large-scale randomized controlled trials (RCTs) have recently been published reporting the incidence of adjudicated cardiovascular events after ferric derisomaltose (FDI) and iron sucrose (IS). The objective was to calculate the relative incidence of cardiovascular events with FDI and IS, and to conduct an indirect comparison with ferric carboxymaltose (FCM) based on previously published studies of cardiovascular risk. Read More

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Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia.

Blood Adv 2022 Aug 10. Epub 2022 Aug 10.

UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

In sickle cell disease (SCD), the relative importance of reduced hemoglobin and peripheral oxygen saturation (SpO2) on brain structure remains uncertain. We applied graph-theoretical analysis to diffusion MRI data to investigate the effect of structural brain connectivity on cognitive function, alongside presence/absence, number and volume of silent cerebral infarction (SCI). In patients, we investigated the relationships between network properties, blood oxygenation and cognition (working memory, WMI, and processing speed, PSI, indices). Read More

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Clinical characteristics of heart failure patients with mid-range ejection fraction.

Acta Cardiol 2022 Aug 10:1-8. Epub 2022 Aug 10.

Research Group on Heart Failure, IIS Aragón, Zaragoza, Spain.

Background: We aimed to characterise and compare the clinical profile of heart failure (HF) with mid-range (HFmrEF), reduced (HFrEF) and preserved (HFpEF) left-ventricular ejection fraction.

Methods: We conducted a descriptive, observational study in 267 HF patients admitted to the Internal Medicine department of a tertiary hospital during 2010-2016. The study population was divided into three groups according to the ejection fraction rate: HFrEF (<40%), HFmrEF (40-49%), and HFpEF (≥50%). Read More

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Nutritional Deficiencies in Morbid Obese Patients Before and After Laparoscopic Sleeve Gastrectomy.

Turk J Gastroenterol 2022 Aug 10. Epub 2022 Aug 10.

Türkçapar Bariatrics, Obesity Center, İstanbul, Turkey.

Background: This study aims to assess the prevalence of preoperative and postoperative nutritional deficiencies and associated factors in patients who are eligible for laparoscopic sleeve gastrectomy.

Methods: Patients who underwent primary laparoscopic sleeve gastrectomy between December 2018 and April 2020 were included in the study. All patients were screened by detailed laboratory tests pre- and post-laparoscopic sleeve gastrectomy 6th and 12th months. Read More

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Interaction of hemoglobin, transfusion, and acute kidney injury in patients undergoing cardiopulmonary bypass: a group-based trajectory analysis.

Ren Fail 2022 Dec;44(1):1368-1375

Department of Intensive Care, Zhejiang Hospital, Hangzhou, China.

Anemia is a risk factor for acute kidney injury (AKI) following cardiopulmonary bypass (CPB). Whether red blood cell (RBC) transfusion-enhanced hemoglobin levels contribute to low AKI rates remains unclear. We investigated the interaction between hemoglobin, RBC transfusion, and AKI after CPB. Read More

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December 2022

A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma Patients.

Hematol Oncol 2022 Aug 10. Epub 2022 Aug 10.

Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Ruxolitinib with lenalidomide and dexamethasone shows anti-myeloma effects in vitro and in vivo. MUC1 leads to lenalidomide resistance in multiple myeloma (MM) cells, and ruxolitinib blocks its expression. Thus, ruxolitinib may restore sensitivity to lenalidomide. Read More

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Sutimlimab for treatment of cold agglutinin disease: why, how and for whom?

Immunotherapy 2022 Aug 10. Epub 2022 Aug 10.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Therapies for cold agglutinin disease have been directed at the pathogenic B-cell clone. Sutimlimab, a monoclonal antibody that targets C1s, is the first complement inhibitor to be extensively studied in cold agglutinin disease. Sutimlimab selectively blocks the classical activation pathway and leaves the alternative and lectin pathways intact. Read More

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