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MMW Fortschr Med 2020 Aug;162(14):22-24

Institut für Biochemie und Molekulare Zellbiologie (IBMZ) Interdisziplinäre Arbeitsgruppe Eisenstoffwechsel, Martinistr. 52, D-20246, Hamburg, Deutschland.

Curr Hematol Malig Rep 2020 Aug 11. Epub 2020 Aug 11.

Section of Hematology/Oncology, Department of Medicine, University of Chicago Medicine, 5841 S. Maryland Avenue, MC 2115, Chicago, IL, 60637, USA.

Purpose Of Review: Ruxolitinib is the first FDA-approved JAK inhibitor for the treatment of myeloproliferative neoplasms and is an effective means of controlling symptom burden and improving splenomegaly. However, a majority of patients will develop disease progression with long-term use. Fedratinib, momelotinib, and pacritinib are three newer-generation JAK inhibitors being prospectively evaluated and we will discuss their roles in the treatment of myeloproliferative neoplasms. Read More

J Clin Sleep Med 2020 Aug 11. Epub 2020 Aug 11.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

Study Objectives: To characterize older adult Medicare beneficiaries seen by board-certified sleep medicine providers (BCSMPs) and identify predictors of being seen by a BCSMP.

Methods: Our data source was a random 5% sample of Medicare administrative claims data (2006-2013). BCSMPs were identified using a cross-matching procedure based on national provider identifiers (NPIs) available within the Medicare database and assigned based on the first sleep disorder diagnosis received. Read More

Pediatr Blood Cancer 2020 Aug 11:e28652. Epub 2020 Aug 11.

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background: Myelodysplastic syndromes (MDS) represent a group of clonal hematopoietic stem cell disorders that commonly progress to acute myeloid leukemia (AML). The diagnostics, prognostics, and treatment of adult MDS are established but do not directly translate to children and adolescents. Pediatric MDS is a rare disease, characterized by unique cytogenetics and histology compared with adult MDS, and often arises secondary to germline predisposition or cytotoxic exposures. Read More

J Vet Intern Med 2020 Aug 11. Epub 2020 Aug 11.

Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, Davis, California, USA.

Background: Azotemia occurs in cats administered doxorubicin, but risk factors have not been explored.

Objective: To determine incidence of progressive increases in serum creatinine concentration in cats with cancer receiving doxorubicin in single or multiagent chemotherapy protocols and associated risk factors.

Animals: Seventy cats with cancer receiving doxorubicin. Read More

J Bras Nefrol 2020 Aug 10. Epub 2020 Aug 10.

University Corporation Antonio Jose de Sucre, Sincelejo, Sucre, Colombia.

Primary atypical hemolytic-uremic syndrome is a rare disease characterized by non-immune microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction; it is related to alterations in the regulation of the alternative pathway of complement due to genetic mutations. The association with nephrotic syndrome is unusual. We present here a pediatric patient diagnosed with primary atypical hemolytic-uremic syndrome associated with nephrotic syndrome who responded to eculizumab treatment. Read More

Biomater Sci 2020 Aug 11. Epub 2020 Aug 11.

Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P.R. China.

Multiple myeloma (MM), known as a tumor of plasma cells, is not only refractory but also has a high relapse rate, and is the second-most common hematologic tumor after lymphoma. It is often accompanied by multiple osteolytic damage, hypercalcemia, anemia, and renal insufficiency. In terms of diagnosis, conventional detection methods have many limitations, such as it is invasive and time-consuming and has low accuracy. Read More

Turk J Pediatr 2020 ;62(4):652-656

Department of Allergy and Immunology, Dr. Behçet Uz Children Research and Training Hospital, İzmir, Turkey.

Background: The recently described FBXL4-related encephalomyopathic mitochondrial DNA depletion syndrome 13 (MTDPS13) manifests with severe encephalopathy, early-onset lactic acidosis, hypotonia, developmental delay and feeding difficulty. Less than 100 cases with FBXL4-related MTDPS13 and 47 pathogenic mutations in the FBXL4 gene have been identified thus far. Here, we describe a patient diagnosed with MTDPS13 with two novel variants of the FBXL4 gene. Read More

Turk J Pediatr 2020 ;62(4):525-532

Departments of Pediatric Hematology-Oncology, Dr. Behçet Uz Children Research and Training Hospital, İzmir, Turkey.

Background And Objectives: Autoimmune cytopenias are a group of heterogeneous disorders characterized by immune-mediated destruction of one or more hematopoietic lineage cells. The differential diagnosis of children with autoimmune cytopenias requires much time and laboratory investigations. The aim of the present study was to evaluate the clinical course and significance of autoimmune cytopenias due to immunodeficiency or autoimmune diseases in children at a single children`s hospital. Read More

Clin Exp Nephrol 2020 Aug 10. Epub 2020 Aug 10.

Department of Nephrology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, 299 Qingyang Rd, Wuxi, Jiangsu, 214023, China.

Background: ESRD (End-stage renal disease) treatment is a comprehensive medical process and requires numerous serological biochemical tests (SBTs) in diagnosis. To reduce these invasive, expensive, cumbersome, and time-consuming SBTs, there is a need to develop an alternative serological biochemical composition evaluation method. Bioelectrical impedance analysis (BIA) is affected by body's chemical and physical components, which might be correlated with serological biochemical composition and can be potentially used to evaluate biochemical composition in hemodialysis patient treatments. Read More

Proc Natl Acad Sci U S A 2020 Aug 10. Epub 2020 Aug 10.

Seraphina Therapeutics, Inc., San Diego, CA 92106.

While it is believed that humans age at different rates, a lack of robust longitudinal human studies using consensus biomarkers meant to capture aging rates has hindered an understanding of the degree to which individuals vary in their rates of aging. Because bottlenose dolphins are long-lived mammals that develop comorbidities of aging similar to humans, we analyzed data from a well-controlled, 25-y longitudinal cohort of 144 US Navy dolphins housed in the same oceanic environment. Our analysis focused on 44 clinically relevant hematologic and clinical chemistry measures recorded during routine blood draws throughout the dolphins' lifetimes. Read More

Clin Lymphoma Myeloma Leuk 2020 Jul 16. Epub 2020 Jul 16.

Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL. Electronic address:

Introduction: Anemia in myelofibrosis (MF) occurs frequently, is poorly addressed by US Food and Drug Administration-approved JAK inhibitors, and negatively impacts quality of life. Immunomodulatory imide agents (IMiDs) such as thalidomide and lenalidomide are among the limited treatment options that have demonstrated anemia benefit in single-arm studies.

Patients And Methods: To better understand the comparative impact of lenalidomide and thalidomide in MF patients, we analyzed 176 consecutive MF patients who received lenalidomide or thalidomide for at least 4 weeks. Read More

Rev Esp Cardiol (Engl Ed) 2020 Aug 7. Epub 2020 Aug 7.

Servicio de Cardiología, Hospital Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Introduction And Objectives: To evaluate the interaction between comorbidity burden and the benefits of in-hospital revascularization in elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS).

Methods: This retrospective study included 7211 patients aged ≥ 70 years from 11 Spanish NSTEACS registries. Six comorbidities were evaluated: diabetes, peripheral artery disease, cerebrovascular disease, chronic pulmonary disease, renal failure, and anemia. Read More

BMC Public Health 2020 Aug 10;20(1):1221. Epub 2020 Aug 10.

School of Health and Environmental Studies, Hamdan Bin Mohammed Smart University, Dubai, United Arab Emirates.

Background: Between 2010 and 2018, measles-related mortality had halved in India mainly with effective measles vaccination campaigns and widespread coverage across the states and population subgroups. Despite the commendable vaccination coverage, 2.9 million children in India missed the first dose of measles vaccine (MCV1) in 2017, and many of those vaccinated were not vaccinated at the recommended age (i. Read More

Nutr Neurosci 2020 Aug 11:1-10. Epub 2020 Aug 11.

Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.

This study examined how the lower cognitive skills in children who consumed iron-fortified formula in infancy relate to outcomes in young adulthood. Participants were 443 Chilean young adults ( age = 21.2y, 55% female) who took part in a randomized controlled iron-deficiency anemia preventive trial during infancy (6-12 m). Read More

J Matern Fetal Neonatal Med 2020 Aug 10:1-6. Epub 2020 Aug 10.

Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.

Background: Maternal morbidity presents a growing challenge to the American healthcare system and increasing numbers of patients are requiring higher levels of care in pregnancy. Identifying patients at high risk for critical care interventions, including intensive care unit admission, during delivery hospitalizations may facilitate appropriate multidisciplinary planning and lead to improved maternal safety. Baseline risk factors for critical care in pregnancy have not been well-described previously. Read More

Urology 2020 Aug 7. Epub 2020 Aug 7.

Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. Electronic address:

Purpose: To present the clinicopathological characteristics and outcome of children with bladder and ureteral inflammatory myofibroblastic tumors (IMTs) in our center.

Methods: We reviewed the medical records of patients with bladder and ureteral IMTs from 2010 to 2018. We recorded patients' demographic data, presentation, hemoglobin level, presence of hydronephrosis, tumor size, treatment, and outcomes. Read More

Paediatr Anaesth 2020 Aug 10. Epub 2020 Aug 10.

Department of Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital, Houston, Texas, USA.

The Kasabach-Merritt phenomenon is a rare, life threatening condition characterized by a consumptive coagulopathy resulting in thrombocytopenia, hypofibrinogenemia, hemolytic anemia, and clotting factor deficiencies(1)with mortality rates as high as 30%(1). The Kasabach-Merritt phenomenon is a consumptive coagulopathy that can accompany certain highly vascular tumors which often present during the neonatal period and may involve the head and neck potentially obstructing the airway. However, treatment of coagulopathy can increase tumor burden and should be carefully considered. Read More

Am J Hematol 2020 Aug 10. Epub 2020 Aug 10.

Vanderbilt-Meharry Sickle Cell Center for Excellence, Vanderbilt University Medical Center, Nashville, TN.

Blood Adv 2020 Aug;4(15):3688-3698

Department of Mechanical and Aerospace Engineering, Case School of Engineering, and.

Sickle cell disease (SCD), which afflicts 100 000 Americans, as well as millions worldwide, is associated with anemia, lifelong morbidity, and early mortality. Abnormal adhesion of sickle red blood cells (RBCs) to activated vascular endothelium may contribute acutely to the initiation of painful vaso-occlusive crises and chronically to endothelial damage in SCD. Sickle RBCs adhere to activated endothelium through several adhesion mechanisms. Read More

Blood Adv 2020 Aug;4(15):3699-3707

Department of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Hairy cell leukemia (HCL) remains an incurable disease. However, first-line treatment with either intravenous or subcutaneous cladribine generally leads to long-lasting remissions. Although there are excellent long-term data for intravenous application, similar data regarding subcutaneous administration are lacking. Read More

PLoS One 2020 10;15(8):e0236720. Epub 2020 Aug 10.

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Hemoglobin (Hb) is associated with cerebral oxygenation status owing to its important role of carrying oxygen to systemic tissues. However, data concerning the associations between Hb levels and cerebral regional oxygen saturation (rSO2) of hemodialysis (HD) patients is limited. We aimed to identify these associations to consider a target Hb level for renal anemia management. Read More

Clin Lab 2020 Aug;66(8)

Background: Anemia is a frequent disorder worldwide. Iron deficiency anemia (IDA) is the most common form of anemia. Although oral iron is the first choice for treatment, the efficacy of oral iron preparations may be limited. Read More

Pediatr Blood Cancer 2020 Aug 9:e28444. Epub 2020 Aug 9.

Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Background: Recent data show survival after matched unrelated donor (MUD) bone marrow transplantation (BMT) is similar to matched sibling procedures for young patients with severe aplastic anemia (SAA). Donor delays, risk of transplant-related mortality (TRM), and concern about chronic graft versus host disease raise questions about whether MUD BMT or immune suppression therapy (IST) should be preferred initial therapy for young patients lacking matched sibling donors.

Procedure: We performed a pilot trial to assess the feasibility of randomizing patients under age 26 with newly diagnosed SAA to receive IST versus MUD BMT. Read More

Pediatr Blood Cancer 2020 Aug 9:e28511. Epub 2020 Aug 9.

Division of Pediatric Hematology/Oncology, Staten Island University Hospital Northwell Health, Staten Island, New York, New York.

J Bras Nefrol 2020 Aug 7. Epub 2020 Aug 7.

Centro Hospitalar de Trás-os-Montes e Alto Douro, Serviço de Nefrologia, Vila Real, Portugal.

The pregnancy rate of women on dialysis is still very low when compared to that of the remaining population. However, recent years have seen an increase in the success rates of these pregnancies. Among the main precautions that must be taken with pregnant women on dialysis are the maintenance of low levels of pre-dialysis urea, the adequacy of the tension profile, the control of anemia and care to avoid infections, nutritional deficits, changes in phosphorus-calcium metabolism and electrolytic fluctuations. Read More

Heliyon 2020 Jul 30;6(7):e04558. Epub 2020 Jul 30.

Epidemiology, Applied Economics, Public Health, School of Microbiology of the University of Antioquia, Colombia.

Introduction: Pregnancy-associated malaria (PAM) is a health problem with serious clinical, epidemiological and economic effects.

Purpose: To analyze the microeconomic evaluations of PAM reported in the world scientific literature.

Methods: Systematic review with 15 different search strategies in PubMed, ScienceDirect, Scielo, Google Scholar and Malaria in Pregnancy (MiP) Library. Read More

Am J Med Case Rep 2020 29;8(9):281-283. Epub 2020 May 29.

Department of Medicine, State University of New York Downstate Health Science University, Brooklyn, NY 11203 USA.

Background: Left ventricular non-compaction cardiomyopathy (LVNC) is a rare congenital cardiomyopathy characterized by increased trabeculation in one or more segments of the ventricle. LVNC presented with non-specific symptoms and highly variable clinical presentation ranging from asymptomatic to progressive heart failure and recurrent or life-threatening arrhythmias.

Case Presentation: 54-year-old Black man with a history of hypertension, diabetes and end-stage renal disease presented with one day palpitations and lightheadedness following a dialysis session. Read More

Int J Cardiol Heart Vasc 2020 Oct 30;30:100597. Epub 2020 Jul 30.

Clinical Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-ayutthaya Road, Phyathai, Ratchathewi, Bangkok 10400, Thailand.

Background: Heart failure (HF) has become a significant health burden in developing countries where anemia is highly prevalent. Limited data exists on the effects of anemia on HF in these population.

Methods: A retrospective observational study was conducted in all adult patients hospitalized due to HF at Buriram Hospital in Thailand, during July 2010 to June 2015. Read More

GE Port J Gastroenterol 2020 Jul 10;27(4):244-254. Epub 2020 Jan 10.

Pediatric Gastroenterology, Hepatology and Nutrition Unit and Clinical Academic Center 2CA-Braga, Hospital de Braga, Braga, Portugal.

Anemia is a common extraintestinal manifestation of inflammatory bowel disease (IBD), both in pediatric and in adult patients. Iron deficiency is the main cause of anemia in patients with IBD. Anemia is a clinically relevant comorbidity, with impact on patients' quality of life and it should be timely diagnosed and adequately treated. Read More

Biomed Res Int 2020 26;2020:9371426. Epub 2020 Jul 26.

Clinical College, Hubei University of Chinese Medicine, Wuhan 430000, China.

During hundreds of years of medication, it is believed that the steamed (SPN) can enrich and regulate the blood, replenish the body, and improve the health. The aim of this study was to optimize the steaming conditions of SPN which are related to the hematopoietic effect. In the study, network pharmacology and pharmacological experiments were used to predict and verify the potential hematopoietic active ingredients of SPN. Read More

Cureus 2020 Jul 5;12(7):e9005. Epub 2020 Jul 5.

Internal Medicine, Sheikh Zayed Hospital, Lahore, PAK.

Atypical hemolytic uremic syndrome (aHUS), defines as non-Shiga toxin HUS, is thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and renal impairment. aHUS is associated with high morbidity and mortality, necessitating the need for an early diagnosis to limit target organ damage. Mutations or autoantibodies against specific complement factors over-activate the complement system forming microthrombi. Read More

Cureus 2020 Jul 3;12(7):e8995. Epub 2020 Jul 3.

Internal Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, USA.

Parvovirus B19 infections are prevalent in children and commonly present as slapped cheek fever, also known as the fifth disease. They are seen frequently in daycares and professions that require close contact with children. The most common presentation is a rash that is prominent on the cheeks; less common symptoms include painful or swollen joints (polyarthopathy syndrome). Read More

Anemia 2020 24;2020:6574358. Epub 2020 Jul 24.

Department of Biomedical Sciences, Faculty of Health Sciences, Woldia University, Woldia, Ethiopia.

Background: Anemia in pregnancy is defined as a hemoglobin (Hb) concentration of less than 11 grams (gm)/deciliter (dl) in venous blood. Globally, it affects 1.62 billion people. Read More

Anemia 2020 21;2020:4634709. Epub 2020 Jul 21.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Introduction: Thalassemia bone disease is one of the disease-related complications in patients with thalassemia. Prevalence of fractures and the role of a trabecular bone score (TBS) as a predictive factor for fractures were evaluated in patients with thalassemia.

Methods: A cross-sectional study was conducted in patients with thalassemia aged ≥18 years at Srinagarind Hospital, Khon Kaen University, Thailand. Read More

J Parasitol Res 2020 21;2020:4846102. Epub 2020 Jul 21.

Post Graduate of Department of Parasitology and Microbiology, Medicine Faculty, Universitas Padjadjaran, Bandung, Indonesia.

Worms are still a serious problem for poor and developing countries. Children, especially school-age children, are more at risk of infection. Efforts need to be made to prevent the effects of worms. Read More

Porcine Health Manag 2020 4;6:18. Epub 2020 Aug 4.

Clinic for Swine, Department of Clinical Veterinary Science, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.

Background: Thrombocytopenia is an immune-mediated disease, which affects suckling piglets. Piglets are pale and inactive, show multiple hemorrhages and often die within days. Pathological examination reveals severe haemorrhages and oedema in several organs. Read More

Pan Afr Med J 2020 9;36:78. Epub 2020 Jun 9.

Maternal and Paediatric Critical Care Unit, Hassan II Academic Hospital, Fez, Morocco.

Hepatic infarction is a rare and fatal complication associated with hemolysis, elevated liver enzymes and low platelets syndrome. It can develop into fulminant liver failure and lead to death in 16% of cases. A 25-year-old woman, with unremarkable prenatal history, was sent to gynecological emergency unit for management of severe preeclampsia at 30 weeks and 4 days of pregnancy. Read More

Pan Afr Med J 2020 27;36:40. Epub 2020 May 27.

Département de Chirurgie des Cliniques Universitaires de Lubumbashi, Université de Lubumbashi, Province du Haut-Katanga, Ville de Lubumbashi, République Démocratique du Congo.

Angiosarcoma is a rare tumor which can affect multiple sites. However, it most commonly arises from the skin. Then symptoms have been associated with clinical polymorphism. Read More

Pan Afr Med J 2020 21;36:26. Epub 2020 May 21.

Oncology Department, Jules Bordet Institute, Brussels, Belgium.

Everolimus is a mTOR inhibitor which demonstrates clinical activity in several solid tumors, especially in kidney cancer after first line TKI anti VEGF treatment and in breast cancer in association with exemesthane after failure of aroamatase inhibitors. The purpose of this study was to analyze in clinical practice the tolerance of everolimus in patients with breast cancer and kidney cancer. We conducted a retrospective study on patients followed up for breast cancer and kidney cancer over the period January 2008 - January 2015. Read More

Oncol Lett 2020 Oct 15;20(4):10. Epub 2020 Jul 15.

Medical Oncology Department of Gastrointestinal Cancer, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China.

The fibrinogen-to-albumin ratio (FAR), reflecting the systemic coagulation, nutritional and inflammation status of patients, has matured into a prognostic marker for several tumor types. However, only a few studies have assessed the utility of the FAR as a prognostic indicator in patients with advanced gastric cancer (GC) receiving first-line chemotherapy. In the present study, 273 patients with advanced GC who received first-line chemotherapy between January 2014 and January 2019 at the Cancer Hospital of China Medical University (Shenyang, China) were retrospectively analyzed. Read More

Case Rep Oncol 2020 May-Aug;13(2):783-788. Epub 2020 Jul 2.

Department of Hematology, National Centre for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

The commonest etiologies of new-onset pancytopenia are congenital bone marrow failure syndromes, marrow space-occupying lesions, infections, and peripheral destruction. Nutritional deficiencies, including folate and vitamin B12, can occasionally cause pancytopenia. We report a 48-year-old gentleman who presented with a 1-week history of dizziness and upper gastrointestinal bleeding. Read More

Case Rep Oncol 2020 May-Aug;13(2):760-763. Epub 2020 Jun 30.

Department of Medical Oncology, National Center for Cancer Care and Research, Doha, Qatar.

Iron overload is a common complication in patients with chronic renal failure treated with dialysis prior to the availability of recombinant human erythropoietin therapy. Iron overload was the result of hypoproliferative erythroid marrow function coupled with the need for frequent red blood cell transfusions to manage symptomatic anemia. The repetitive use of intravenous iron with or without the use of red blood cell transfusions also contributed to iron loading and was associated with iron deposition in liver parenchymal and reticuloendothelial cells. Read More

Case Rep Oncol 2020 May-Aug;13(2):721-724. Epub 2020 Jun 24.

Department of Medical Oncology, National Center for Cancer Care and Research, Doha, Qatar.

Iron deficiency anemia is common and worldwide distributed, particularly among females; however, it can also occur among males. Iron deficiency anemia is commonly associated with thrombocytosis; little is known about the effect of iron therapy (oral or intravenous) on other hematological parameters. We report a 29-year-old male patient with iron deficiency anemia, who received oral iron replacement therapy and developed neutropenia which recovered spontaneously 1 month later. Read More

Case Rep Oncol 2020 May-Aug;13(2):649-654. Epub 2020 Jun 11.

Department of Pathology, Lehigh Valley Health Network, Allentown, Pennsylvania, USA.

Soft tissue sarcomas are common neoplasms accounting for 1% of all adult malignancies; however, soft tissue sarcomas infrequently arise from the abdominal viscera. Many case reports discuss gastric and esophageal neoplasms. In the group of gastrointestinal liposarcomas, primary duodenal liposarcomas are among the rarest, with only three previous cases reported in the literature. Read More

Case Rep Oncol 2020 May-Aug;13(2):643-648. Epub 2020 Jun 11.

Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

Background: An isolated metachronous recurrence in the mesorectum from a primary ascending colon cancer is a rare finding that has not been previously reported. This may represent a form of retroperitoneal spread, sometimes referred to as "drop metastasis," which is an uncommon mechanism for metachronous recurrence.

Case Presentation: A 38-year-old male presented to the Emergency Department in January of 2018 with profound anemia. Read More

Dose Response 2020 Jul-Sep;18(3):1559325820941351. Epub 2020 Jul 29.

Department of Pharmacy, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Medicine School of University of Electronic Science and Technology, Chengdu, People's Republic of China.

Background: Trials reported there are beneficial effects of the addition of bevacizumab to chemotherapy in advanced cervical cancer but might have adverse effects. The purposes of the study were to evaluate the treatment response and safety of the addition of bevacizumab to paclitaxel plus carboplatin in advanced cervical cancer women.

Methods: Data on treatment response, adverse effects, and overall survival of women who received paclitaxel plus carboplatin every 3 weeks (ACT cohort, n = 161) or paclitaxel, carboplatin, and bevacizumab every 3 weeks (PCB cohort, n = 127) until disease progression or severe adverse events were collected and analyzed. Read More

Thromb J 2020 3;18:14. Epub 2020 Aug 3.

Department of Internal Medicine, Kantonsspital Aarau, 5000 Aarau, Switzerland.

Background: Anticoagulants are commonly prescribed in medical practices and could be of significant harm in the case of medication errors. We conducted a retrospective observational study to determine the frequency and consequences of the therapeutic duplication of anticoagulants (TDA). As a secondary objective, we aimed to determine the characteristics of the population in which TDA occurs. Read More

Am J Case Rep 2020 Aug 10;21:e923750. Epub 2020 Aug 10.

Department of Internal Medicine, Overlook Medical Center, Summit, NJ, USA.

BACKGROUND Myasthenia gravis (MG) is an autoimmune disease characterized by antibodies binding skeletal muscle acetylcholine receptors (AChR). Rarely does the disease manifest with orolaryngeal symptoms before ocular ones. We present a case of MG that on initial presentation had symptoms of cranial nerves (CN) IX and X weakness, including dysphagia and dysphonia. Read More

Transfus Apher Sci 2020 Aug 3:102900. Epub 2020 Aug 3.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Erciyes University, Faculty of Medicine, Kayseri, Turkey.

Introduction: Hepatitis-associated aplastic anemia is a rare type of acquired aplastic anemia that occurs after hepatitis. This study investigated cases with hepatitis-associated aplastic anemia.

Methods: The files of patients with hepatitis-associated aplastic anemia who were followed up in our hospital between 2011-2019 were reviewed retrospectively. Read More