213,745 results match your criteria Anemia


Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination.

Cell Rep 2019 Jan;26(3):564-572.e5

Department of Pediatrics, Yale Medical School, New Haven, CT 06520, USA; Department of Pathology, Yale Medical School, New Haven, CT 06520, USA. Electronic address:

Fanconi anemia (FA) is characterized by developmental abnormalities, bone marrow failure, and cancer predisposition. FA cells are hypersensitive to DNA replicative stress and accumulate co-transcriptional R-loops. Here, we use the Damage At RNA Transcription assay to reveal colocalization of FANCD2 with R-loops in a highly transcribed genomic locus upon DNA damage. Read More

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http://dx.doi.org/10.1016/j.celrep.2018.12.084DOI Listing
January 2019

The Best Cutoff Value of Middle Cerebral Artery Peak Systolic Velocity for the Diagnosis of Fetal Homozygous Alpha Thalassemia-1 Disease.

Prenat Diagn 2019 Jan 16. Epub 2019 Jan 16.

Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objective: To determine the best cutoff value of middle cerebral artery peak systolic velocity (MCA-PSV) for the diagnosis of fetuses with homozygous alpha thalassemia-1 disease.

Methods: Pregnancies at risk for fetal homozygous alpha thalassemia-1 disease at 18-22 weeks were recruited. MCA-PSV was measured before cordocentesis for hemoglobin typing and complete blood count. Read More

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http://dx.doi.org/10.1002/pd.5419DOI Listing
January 2019

Sea lice, Lepeophtheirus salmonis (Krøyer 1837), infected Atlantic salmon (Salmo salar L.) are more susceptible to infectious salmon anemia virus.

PLoS One 2019 16;14(1):e0209178. Epub 2019 Jan 16.

Aquaculture Research Institute, University of Maine, Hitchner Hall, Orono, Maine, United States of America.

The role of parasitic sea lice (Siphonostomatoida; Caligidae), especially Lepeophtheirus salmonis, in the epidemiology of Infectious Salmon Anemia Virus (ISAv) has long been suspected. The epidemiological studies conducted during the 1998 major Infectious Salmon Anaemia (ISA) outbreak in Scotland demonstrated a strong correlation between sea lice presence and ISAv positive sites or subsequent clinical outbreaks of ISA. The question posed from this observation was "do sea lice infestations on Atlantic salmon make them more susceptible to viral infections?" This study investigated the role that sea lice infestations have on the severity of ISAv infections and disease mortality in experimental populations of farmed Atlantic salmon (Salmo salar). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209178PLOS
January 2019

Serum albumin level and long-term outcome in acute heart failure.

Acta Cardiol 2019 Jan 16:1-7. Epub 2019 Jan 16.

a University Hospital of Liège, GIGA Cardiovascular Sciences, Acute Care Unit, Heart Failure Clinic, CHU Sart Tilman , Liège , Belgium.

Objective: Hypoalbuminemia is common in heart failure (HF), especially in elderly patients. It is associated with an increased risk of death. The present study sought to examine the prognostic significance of serum albumin level in the prediction of long-term mortality in patients admitted for acute HF. Read More

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http://dx.doi.org/10.1080/00015385.2018.1521557DOI Listing
January 2019

Impact of the Nutrition-Friendly School Initiative: analysis of anthropometric and biochemical data among school-aged children in Ouagadougou.

Glob Health Promot 2019 Jan 16:1757975918789350. Epub 2019 Jan 16.

2 University of Montreal, Montreal, Quebec, Canada.

The Nutrition-Friendly School Initiative was developed in 2006 to counter the double burden of malnutrition and implemented on a pilot basis in primary schools in Ouagadougou (Burkina Faso) in 2009. A baseline study was conducted in intervention and control schools and repeated in 2014 to assess the impact. This paper reports on anthropometric and biochemical data in the final and baseline surveys. Read More

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http://dx.doi.org/10.1177/1757975918789350DOI Listing
January 2019

Exercise training in kidney transplant recipients: a systematic review.

J Nephrol 2019 Jan 16. Epub 2019 Jan 16.

Division of Nephrology, Dialysis and Transplantation, Nephrology Unit, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.

Background And Aims: Evidences on the benefits of physical exercise in kidney transplant patients (KTx) are not conclusive and concerns on safety remain. We here gather and interpret current evidence on the benefits/harms of exercise training intervention in KTx.

Methods: Systematic review of exercise training programs in KTx. Read More

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http://dx.doi.org/10.1007/s40620-019-00583-5DOI Listing
January 2019

Ironing out the Relation between Iron Supplementation and Exercise Performance in the Absence of Anemia.

J Nutr 2019 Jan 10. Epub 2019 Jan 10.

Department of Nutrition, Food, and Exercise Sciences, Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL.

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http://dx.doi.org/10.1093/jn/nxy288DOI Listing
January 2019

Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial.

Am J Clin Nutr 2019 Jan 15. Epub 2019 Jan 15.

Center of Excellence for Nutrition, North-West University, Potchefstroom, South Africa.

Background: Evidence on the effect of small-quantity lipid-based nutrient supplements (SQ-LNSs) on early child growth and development is mixed.

Objective: This study assessed the effect of daily consumption of 2 different SQ-LNS formulations on linear growth (primary outcome), psychomotor development, iron status (secondary outcomes), and morbidity in infants from age 6 to 12 mo within the context of a maize-based complementary diet.

Methods: Infants (n = 750) were randomly assigned to receive SQ-LNS, SQ-LNS-plus, or no supplement. Read More

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http://dx.doi.org/10.1093/ajcn/nqy282DOI Listing
January 2019

7 Is the New 8: Improving Adherence to Restrictive PRBC Transfusions in the Pediatric ICU.

J Healthc Qual 2019 Jan 3. Epub 2019 Jan 3.

Up to 30%-40% of children admitted to the pediatric intensive care unit (PICU) have anemia, and approximately 15% receive packed red blood cell (pRBC) transfusions. Current literature supports a pRBC transfusion threshold of hemoglobin less than or equal to seven for most PICU patients. Our objective was to determine pRBC transfusion rates, assess compliance with transfusion guidelines, understand patient-level variables that affect transfusion practices, and use cross-industry innovation to implement a practice strategy. Read More

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http://dx.doi.org/10.1097/JHQ.0000000000000176DOI Listing
January 2019

Mini-commentary on 2018-OG-22151R1: Maternal Anaemia and Maternal, Foetal and Neonatal Outcomes In A Prospective Cohort Study In India and Pakistan.

Authors:
Blair Wylie

BJOG 2019 Jan 16. Epub 2019 Jan 16.

Division of Maternal-Fetal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

In this issue of BJOG, Parks and colleagues from the Global Network for Women's and Children's Health report the results of a large observational cohort of pregnant women from low- and middle-income country settings (LMICs) in India and Pakistan in which they evaluate the prevalence of anaemia during pregnancy and its association with maternal, fetal and neonatal mortality (Parks et al. BJOG xxxx). The authors take advantage of the Global Network's large community-based pregnancy registry in which key clinical information and outcomes are collected prospectively for all pregnancies in participating geographic clusters. Read More

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http://dx.doi.org/10.1111/1471-0528.15613DOI Listing
January 2019

Pernicious anemia and endocrine glands antibodies.

Endokrynol Pol 2019 Jan 16. Epub 2019 Jan 16.

Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Introduction: The aim of the study was to determine the frequency of occurrence of antibodies participating in the development of endocrine diseases in patients with autoimmune hematopoietic disease, thus documenting the potential suitability of specific diagnostic and screening tests.

Material And Methods: The study group consisted of 124 persons (men and women) with newly diagnosed Pernicious Anemia (PA) and the control group (C) of 41 healthy people. Antibodies against: internal factor (IFAb), gastric parietal cells (APCA), thyroid peroxidase (TPOAb), thyroglobulin (TgAb), adrenal cortex (AdrenalAb) and pituitary anterior lobe (PituitaryAb) were determined in the blood. Read More

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http://dx.doi.org/10.5603/EP.a2018.0086DOI Listing
January 2019

Should postoperative haemoglobin and potassium levels be checked routinely following blood-conserving primary total joint arthroplasty?

Bone Joint J 2019 Jan;101-B(1_Supple_A):25-31

Joint Implant Surgeons, Inc., White Fence Surgical Suites, and Mount Carmel Health System, New Albany, Ohio, USA.

Aims: Despite declining frequency of blood transfusion and electrolyte supplementation following total joint arthroplasty, postoperative blood analyses are still routinely ordered for these patients. This study aimed to determine the rate of blood transfusion and electrolyte restoration in arthroplasty patients treated with a perioperative blood conservation protocol and to identify risk factors that would predict the need for transfusion and electrolyte supplementation.

Patients And Methods: Patients undergoing primary total joint arthroplasty of the hip or knee between July 2016 and February 2017 at a single institution were included in the study. Read More

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http://dx.doi.org/10.1302/0301-620X.101B1.BJJ-2018-0554.R1DOI Listing
January 2019

Myelophthisic Anemia in a Patient with Lobular Breast Carcinoma Metastasized to the Bone Marrow.

Cureus 2018 Nov 4;10(11):e3541. Epub 2018 Nov 4.

Hematology / Oncology, The Brooklyn Hospital Center, Brooklyn, USA.

Breast tumors have a predilection for metastasizing to the bone leading to cells being displaced by the cancer cells subsequently producing immature leukocytes and erythrocytes in the peripheral blood. We present a case of a 57-year-old female who was found to have myelophthisic anemia secondary to stage four lobular breast carcinoma metastasized to the bone marrow after being misdiagnosed as having thrombotic thrombocytopenia purpura. Diagnosis of myelophthisic anemia requires a thorough workup and treatment is based upon secondary management of the malignancy. Read More

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http://dx.doi.org/10.7759/cureus.3541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324862PMC
November 2018

Sub-acute Cardiac Tamponade as an Early Clinical Presentation of Childhood Systemic Lupus Erythematosus: A Case Report.

Cureus 2018 Oct 22;10(10):e3478. Epub 2018 Oct 22.

Surgery, Jinnah Sindh Medical University, Karachi, PAK.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple systems by the process of inflammation and formation of auto-antibodies. When it presents in childhood, it is referred to as childhood systemic lupus erythematosus (cSLE). Cardiac tamponade is a rare but potentially lethal complication of cSLE, even rarer as an initial presentation. Read More

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http://dx.doi.org/10.7759/cureus.3478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318088PMC
October 2018

Maternal Mortality at the Dori Regional Hospital in Northern Burkina Faso, 2014-2016.

Int J MCH AIDS 2018 ;7(2):235-241

West African Field Epidemiology Training Program, Ouagadougou, BURKINA FASO.

Background: Maternal mortality is of considerable magnitude. It is particularly relevant to developing countries, including those in Sub-Saharan Africa. The aim of this work was to study the cases of maternal deaths in the Dori Regional Hospital, Burkina Faso in the Sahel region, by analyzing the epidemiological aspects of these deaths in order to guide decision-making. Read More

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http://dx.doi.org/10.21106/ijma263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328931PMC
January 2018

Cyclin-Dependent Kinase 4/6 Inhibitor (Palbociclib) Induced Aplastic Anemia in a Patient with Metastatic Breast Cancer.

Case Rep Hematol 2018 13;2018:9249506. Epub 2018 Dec 13.

Section of Hematology and Medical Oncology, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.

Breast cancer is the most common cancer diagnosed in women worldwide. Over the years, breast cancer treatment has undergone revolutionary changes especially for women with hormone receptor positive metastatic disease. As a result, women are living longer with their disease, particularly in developed countries. Read More

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http://dx.doi.org/10.1155/2018/9249506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311830PMC
December 2018

Effect of iron deficiency anemia on HbA1c in diabetic patients at Tikur Anbessa specialized teaching hospital, Addis Ababa Ethiopia.

BMC Hematol 2019 9;19. Epub 2019 Jan 9.

1College of Medicine and Health Sciences Department of Medical Laboratory Sciences, Wolkite University, Wolkite, Ethiopia.

Background: Hemoglobin A1C (HbA1c) is the predominant hemoglobin found in HbA1 fractions. A1c assay is the recommended assay for diagnosing diabetes and any condition that changes red cell turnover such as Iron deficiency Anemia (IDA), will lead to spurious A1C results. Therefore, the present study was aimed at determining the effect of IDA on HbA1c in diabetic patients attending Black Lion Specialized Teaching Hospital, Addis Ababa, Ethiopia. Read More

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http://dx.doi.org/10.1186/s12878-018-0132-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327502PMC
January 2019

Clinical and pathological factors of renal anaemia in patients with IgA nephropathy in Chinese adults: a cross-sectional study.

BMJ Open 2019 Jan 15;9(1):e023479. Epub 2019 Jan 15.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, People's Republic of China.

Objective: Few studies with large sample populations concerning renal anaemia and IgA nephropathy have been reported worldwide. The purpose of this cross-sectional study was to examine the clinical and pathological characteristics and influencing factors associated with renal anaemia in patients with IgA nephropathy, which is the most common aetiology of chronic kidney disease.

Methods: A total of 462 hospitalised patients with IgA nephropathy confirmed by renal biopsy who met the inclusion criteria were consecutively recruited from January 2014 to January 2016. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023479DOI Listing
January 2019

[The Cutting-edge of Medicine ; Hepcidin and renal anemia].

Authors:
Naohisa Tomosugi

Nihon Naika Gakkai Zasshi 2016 Dec;105(12):2450-2457

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December 2016

[The prevalence of overweight and obesity in moscow pregnant women and principles of alimentary correction of these conditions].

Vopr Pitan 2016 23;85(3):61-70. Epub 2016 Jun 23.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The aim was to study the prevalence of overweight and obesity in Moscow pregnant women, as well as to conduct a comparative study of normal and excessive women`s body weight influence on the course and outcome of pregnancy and delivery, anthropometric indices and state of newborn`s health, to assess women's dietary intake and to develop approaches to nutritional correction of overweight and obesity in pregnant women. The prevalence of overweight and obesity among pregnant women in Moscow in 2009-2011 was 8.3% of the total number of pregnant women observed. Read More

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http://dx.doi.org/10.24411/0042-8833-2016-00036DOI Listing

[Thinking on Treatment of Severe Aplastic Anemia by Detoxication, Blood Activating, and Yin Nourishing Method].

Zhongguo Zhong Xi Yi Jie He Za Zhi 2016 Sep;36(9):1132-1134

Chinese medicine therapy has advantages in treating aplastic anemia (AA) in depart- ments of Chinese medicine (CM) blood diseases. But there is no unified syndrome typing standard of CM for severe AA. Heat-toxin induced yin deficiency syndrome is one of severe AA syndrome types com- monly seen in authors' long-term clinical practice. Read More

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September 2016
1 Read

ruxolitinib (JAKAVI°) and polycythaemia vera Inconclusive evaluation.

Authors:

Prescrire Int 2016 Oct;25(175):229-231

Patients with polycythaemia vera, a myeloproliferative syndrome, are at increased risk of thrombotic events. Marrow fibrosis and transformation to acute leukaemia can also occur after several years. Treatment is based on phlebotomy and aspirin at low (antiplatelet) doses, sometimes combined with hydroxycarbamide, a cytotoxic drug. Read More

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October 2016

Trends in Socioeconomic Inequalities and Prevalence of Anemia Among Children and Nonpregnant Women in Low- and Middle-Income Countries.

JAMA Netw Open 2018 Sep 7;1(5):e182899. Epub 2018 Sep 7.

School of Health Policy and Management, Nanjing Medical University, Nanjing, China.

Importance: Anemia remains a major challenge for women's and children's health in low- and middle-income countries (LMICs).

Objective: To assess the socioeconomic inequalities and prevalence of anemia among children and nonpregnant girls and women in LMICs over time.

Design, Setting, And Participants: This cross-sectional and repeated cross-sectional analysis used data from the Demographic and Health Surveys collected from January 1, 2000, through December 31, 2014. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.2899DOI Listing
September 2018
1 Read

Outcomes of self-induced late pregnancy termination in women presenting to a tertiary hospital in the Eastern Cape Province, South Africa.

S Afr Med J 2018 Oct 26;108(11):965-971. Epub 2018 Oct 26.

Walter Sisulu University and Eastern Cape Department of Health, East London, South Africa.

Background: Little is known about the outcomes of self-induced pregnancy termination after 24 weeks' gestation, as previous studies have concentrated on outcomes before 24 weeks.

Objectives: To investigate the gestational age, misoprostol dosage, source of information on misoprostol, reasons for termination and outcomes of self-induced pregnancy termination after 24 weeks' gestation.

Methods: A quantitative, retrospective case series observational research design was utilised. Read More

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http://dx.doi.org/10.7196/SAMJ.2018.v108i11.12979DOI Listing
October 2018
1 Read

Associations between iron deficiency anemia and clinical features among pregnant women: a prospective cohort study [Retraction].

Authors:

J Blood Med 2019 27;10:19. Epub 2018 Dec 27.

[This retracts the article on p. 163 in vol. 9, PMID: 30323700. Read More

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http://dx.doi.org/10.2147/JBM.S198516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312047PMC
December 2018

Comparative effectiveness and safety of traditional Chinese medicine supporting Qi and enriching blood for cancer related anemia in patients not receiving chemoradiotherapy: a meta-analysis and systematic review.

Drug Des Devel Ther 2019 28;13:221-230. Epub 2018 Dec 28.

Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Chaoyang District, Beijing 100015, People's Republic of China,

A systematic review and meta-analysis of previous randomized controlled trials of traditional Chinese medicine (TCM) supporting Qi and enriching blood in the treatment of cancer related anemia (CRA) in patients not receiving chemoradiotherapy were conducted. A total of 13 randomized controlled trials were included. Compared with the control group, better improvement was found for the level of hemoglobin (mean difference=4. Read More

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http://dx.doi.org/10.2147/DDDT.S181182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312692PMC
December 2018

Efficacy and safety of sodium cantharidinate and vitamin B6 injection for the treatment of digestive system neoplasms: a meta-analysis of randomized controlled trials.

Drug Des Devel Ther 2019 28;13:183-203. Epub 2018 Dec 28.

Department of Radiotherapy, Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, Liaocheng 252000, Shandong Province, China,

Objective: To systematically evaluate the efficacy and safety of sodium cantharidinate and vitamin B6 (SC/B6) combined with conventional medical treatment (CMT) for the treatment of patients with advanced digestive system neoplasms (DSNs).

Methods: The Cochrane Library, Embase, PubMed, Web of Science, Chinese Scientific Journal Database (VIP), China National Knowledge Infrastructure, and Wanfang databases were searched for clinical trials using SC/B6 for DSNs. Outcome measures, including therapeutic efficacy, quality of life (QoL), and adverse events, were extracted and systematically evaluated. Read More

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https://www.dovepress.com/efficacy-and-safety-of-sodium-cant
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http://dx.doi.org/10.2147/DDDT.S190674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312696PMC
December 2018
2 Reads

[Diagnosis and treatment for 46 cases of Peutz-Jeghers syndrome].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1323-1327

Department of Gastroenterology, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China.

Objective: To explore the clinical features, pathological features, gene test results, diagnosis, treatment and prognosis of Peutz-Jeghers syndrome(PJS).
 Methods: We retrospectively analyzed clinical data of 46 hospitalized cases of PJS during 2007 and 2017.
 Results: All 46 patients had mucocutaneous melanin pigmentation and multiple gastrointestinal polyposis. Read More

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http://www.csumed.org/xbwk/CN/10.11817/j.issn.1672-7347.2018
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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.007DOI Listing
December 2018
1 Read

Safety and activity of ibrutinib in combination with nivolumab in patients with relapsed non-Hodgkin lymphoma or chronic lymphocytic leukaemia: a phase 1/2a study.

Lancet Haematol 2019 Jan 11. Epub 2019 Jan 11.

Department of Hematology, Jagiellonian University, Krakow, Poland.

Background: Preclinical studies have shown synergistic antitumour effects between ibrutinib and immune-checkpoint blockade. The aim of this study was to assess the safety and activity of ibrutinib in combination with nivolumab in patients with relapsed or refractory B-cell malignant diseases.

Methods: We did a two-part, open-label, phase 1/2a study at 21 hospitals in Australia, Israel, Poland, Spain, Turkey, and the USA. Read More

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http://dx.doi.org/10.1016/S2352-3026(18)30217-5DOI Listing
January 2019

Sex-Differences in the Pattern of Comorbidities, Functional Independence, and Mortality in Elderly Inpatients: Evidence from the RePoSI Register.

J Clin Med 2019 Jan 12;8(1). Epub 2019 Jan 12.

Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy.

Background: The RePoSi study has provided data on comorbidities, polypharmacy, and sex dimorphism in hospitalised elderly patients.

Methods: We retrospectively analysed data collected from the 2010, 2012, 2014, and 2016 data sets of the RePoSi register. The aim of this study was to explore the sex-differences and to validate the multivariate model in the entire dataset with an expanded follow-up at 1 year. Read More

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http://dx.doi.org/10.3390/jcm8010081DOI Listing
January 2019

Distinguishing iron deficiency anemia from thalassemia by the red blood cell lifespan with a simple CO breath test: A pilot study.

J Breath Res 2019 Jan 14. Epub 2019 Jan 14.

Haikou Municipal People's Hospital, Affiliated Haikou Hospital Xiangya School of Medicine Central South University, Haikou, CHINA.

Background: Extant indices for distinguishing between iron deficiency anemia (IDA) and thalassemia (Thal) have substantial practical limitations. The aim of this pilot study was to assess the predictive value of red blood cell lifespan (RBCLS), as determined by an automated CO breath test analysis approach, in the differential diagnosis of these two common forms of microcytic hypochromic anemia (MHA). Methods: RBCLS measurements were conducted in 35 healthy controls (HCs) and 114 patients diagnosed with MHA (IDA, N = 59; and Thal, N = 55) with ELS TESTER that provides a direct RBCLS value read-out. Read More

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http://dx.doi.org/10.1088/1752-7163/aafe4fDOI Listing
January 2019

S-1 combined with paclitaxel may benefit advanced gastric cancer: evidence from a systematic review and meta-analysis.

Int J Surg 2019 Jan 12. Epub 2019 Jan 12.

Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, China.

Background: Gastric cancer, as one of the increasingly common malignancies, has experienced high morbidity throughout many countries at present. Currently, chemotherapy regimen with more efficacy and safety for advanced gastric cancer (AGC) is needed. We aimed to assess the clinical efficacy and safety of S-1 combined with paclitaxel (PTX) for AGC by performing a systematic review and meta-analysis of the published studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17439191183170
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http://dx.doi.org/10.1016/j.ijsu.2018.11.010DOI Listing
January 2019
2 Reads

Consider Allogeneic Bone Marrow Transplantation for Older, Fit Patients with Aplastic Anemia.

Authors:
George E Georges

Biol Blood Marrow Transplant 2019 Jan 11. Epub 2019 Jan 11.

Associate Member, Fred Hutchison Cancer Research Center, Seattle, Washington; Associate Professor, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.01.015DOI Listing
January 2019

Comparable Outcome with a Faster Engraftment of Optimized Haploidentical Hematopoietic Stem Cell Transplantation Compared to Transplantations from Other Donor Types in Pediatric Acquired Aplastic Anemia.

Biol Blood Marrow Transplant 2019 Jan 10. Epub 2019 Jan 10.

Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, Seoul, Korea.

Haploidentical family donors have been used as an alternative source in hematopoietic cell transplantation for patients with severe aplastic anemia. We evaluated and compared the outcomes of transplantation in pediatric-acquired severe aplastic anemia based on donor type. Sixty-seven patients who underwent transplantation between 1998 and 2017 were included. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.01.010DOI Listing
January 2019

The changing face of chronic autoimmune atrophic gastritis: an updated comprehensive perspective.

Autoimmun Rev 2019 Jan 10. Epub 2019 Jan 10.

Division of Gastroenterology and Center for Autoimmune Liver Diseases, San Gerardo Hospital, Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy.

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http://dx.doi.org/10.1016/j.autrev.2018.08.011DOI Listing
January 2019

Circulatory control of phrenic motor plasticity.

Respir Physiol Neurobiol 2019 Jan 10. Epub 2019 Jan 10.

Center for Respiratory Research and Rehabilitation, Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA. Electronic address:

Acute intermittent hypoxia (AIH) elicits distinct mechanisms of phrenic motor plasticity initiated by brainstem neural network activation versus local (spinal) tissue hypoxia. With moderate AIH (mAIH), hypoxemia activates the carotid body chemoreceptors and (subsequently) brainstem neural networks associated with the peripheral chemoreflex, including medullary raphe serotonergic neurons. Serotonin release and receptor activation in the phrenic motor nucleus then elicits phrenic long-term facilitation (pLTF). Read More

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http://dx.doi.org/10.1016/j.resp.2019.01.004DOI Listing
January 2019

[Short-term effects with sucroferric oxyhydroxide in hemodialysis patients: Experience in NephroCare France].

Nephrol Ther 2019 Jan 10. Epub 2019 Jan 10.

NephroCare Tassin-Charcot, 69110 Sainte-Foy-Lès-Lyon, France.

Introduction: Despite a better management of hyperphosphatemia in haemodialysis patients observed during the past years, most of them remain insufficiently treated and exposed to bone and cardiovascular complications that are associated with this biological abnormality. The availability of calcium-free phosphate binders among therapeutical options is confirmed to significantly reduce serum phosphate levels without the risk of excess exposure to calcium. Currently sucroferric oxyhydroxyde (SO) is the only iron-based phosphate binder available in France. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.08.003DOI Listing
January 2019

The Tumor Suppressor PALB2: Inside Out.

Trends Biochem Sci 2019 Jan 10. Epub 2019 Jan 10.

CHU de Québec Research Center, Oncology Division, 9 McMahon, Québec City, QC, G1R 3S3, Canada; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Québec City, QC, G1V 0A6, Canada. Electronic address:

Partner and Localizer of BRCA2 (PALB2) has emerged as an important and versatile player in genome integrity maintenance. Biallelic mutations in PALB2 cause Fanconi anemia (FA) subtype FA-N, whereas monoallelic mutations predispose to breast, and pancreatic familial cancers. Herein, we review recent developments in our understanding of the mechanisms of regulation of the tumor suppressor PALB2 and its functional domains. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09680004183021
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http://dx.doi.org/10.1016/j.tibs.2018.10.008DOI Listing
January 2019
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[Gaucher disease: A review].

Rev Med Interne 2019 Jan 10. Epub 2019 Jan 10.

Service de médecine interne, hôpitaux universitaires Paris Nord-Val-de-Seine, hôpital Beaujon, Assistance publique-Hôpitaux de Paris (AP-HP), 100, boulevard du Général-Leclerc, 92110 Clichy, France; Centre de référence des maladies lysosomales, hôpitaux universitaires Paris Nord-Val-de-Seine, hôpital Beaujon, Assistance publique-Hôpitaux de Paris (AP-HP), 100, boulevard du Général-Leclerc, 92110 Clichy, France.

Gaucher disease is a rare autosomal recessive genetic disease, caused by a deficiency of the lysosomal enzyme, glucocerebrosidase that leads to the accumulation of its substrate (glucosylceramide) in lysosomal macrophages. In the general population, its incidence varies between 0.4 and 5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02488663183118
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http://dx.doi.org/10.1016/j.revmed.2018.11.012DOI Listing
January 2019
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The blood transcriptome of childhood malaria.

EBioMedicine 2019 Jan 9. Epub 2019 Jan 9.

Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany; Vietnamese-German Center for Medical Research, Hanoi, Viet Nam; Duy Tan University, Da Nang, Viet Nam. Electronic address:

Background: Transcriptomic research of blood cell lineages supports the understanding of distinct features of the immunopathology in human malaria.

Methods: We used microarray hybridization, validated by real-time RT-PCR to analyze whole blood gene expression in healthy Gabonese children and children with various conditions of Plasmodium falciparum infection, including i) asymptomatic infection, ii) uncomplicated malaria, iii) malaria associated with severe anemia and iv) cerebral malaria.

Findings: Our data indicate that the expression profile of 22 genes significantly differed among the investigated groups. Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.12.055DOI Listing
January 2019

Efficacy and safety of niraparib as maintenance treatment in older patients (≥ 70 years) with recurrent ovarian cancer: Results from the ENGOT-OV16/NOVA trial.

Gynecol Oncol 2019 Jan 9. Epub 2019 Jan 9.

Dana-Farber Cancer Institute, Boston, MA, USA.

Objective: To analyze the safety and efficacy of niraparib in patients aged ≥70 years with recurrent ovarian cancer in the ENGOT-OV16/NOVA trial.

Methods: The trial enrolled 2 independent cohorts with histologically diagnosed recurrent ovarian, fallopian tube, or peritoneal cancer who responded to platinum rechallenge, on the basis of germline breast cancer susceptibility gene mutation (gBRCAmut) status. Patients were randomized 2:1 to receive niraparib (300 mg) or placebo once daily until disease progression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183147
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http://dx.doi.org/10.1016/j.ygyno.2018.12.009DOI Listing
January 2019
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The Role of Plasmapheresis in Treating Lethal Cupric Sulfate Poisoning.

Authors:
Yu Du Yi Mou

Am J Med Sci 2018 Nov 29. Epub 2018 Nov 29.

Geroscience and Chronic Disease Department, The 8th Municipal People's Hospital, Chengdu, China. Electronic address:

The mortality rate of cupric sulfate is relatively high in contrast to that of other heavy metals. Cases of orally ingested cupric sulfate poisoning are very rare, with a reported half lethal dose of 10 g. Cupric sulfate poisoning leads to gastrointestinal corrosion, intravascular hemolysis, hemolytic anemia, methemoglobinemia and acute renal and hepatic impairment. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.014DOI Listing
November 2018

A mummy emerges from the grave: Scurvy confounding the clinical presentation of a child with Fanconi Anemia.

Am J Hematol 2019 Jan 13. Epub 2019 Jan 13.

Division of Pediatric Hematology, Oncology & HSCT Center, Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey.

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http://dx.doi.org/10.1002/ajh.25402DOI Listing
January 2019

Acquisition of Streptococcus mutans and dental caries experience in pediatric sickle cell anaemia patients under various prophylactic therapies.

Eur Arch Paediatr Dent 2019 Jan 14. Epub 2019 Jan 14.

Department of Oral Medicine and Radiology, Maitri Dental College, Durg, Chhattisgarh, India.

Objectives: To determine the acquisition of Streptococcus mutans and dental caries experience in children with sickle cell anaemia (SCA) under various prophylactic therapies.

Methods: This study involved a total of 200 children who were divided into five groups comprising of 40 children each. Group SP included children who received prophylactic penicillin, Group SV who received pneumococcal vaccination, Group SPV who received both prophylactic penicillin and pneumococcal vaccination, Group SW who did not receive any prophylactic therapy and Group CC who were controls. Read More

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http://dx.doi.org/10.1007/s40368-019-00415-xDOI Listing
January 2019

Response of an oscillatory differential delay equation to a periodic stimulus.

J Math Biol 2019 Jan 12. Epub 2019 Jan 12.

Departments of Physiology, Physics and Mathematics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, H3G 1Y6, Canada.

Periodic hematological diseases such as cyclical neutropenia or cyclical thrombocytopenia, with their characteristic oscillations of circulating neutrophils or platelets, may pose grave problems for patients. Likewise, periodically administered chemotherapy has the unintended side effect of establishing periodic fluctuations in circulating white cells, red cell precursors and/or platelets. These fluctuations, either spontaneous or induced, often have serious consequences for the patient (e. Read More

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http://dx.doi.org/10.1007/s00285-018-1322-yDOI Listing
January 2019

The Progress of Traditional Chinese Medicine in the Treatment of Aplastic Anemia.

J Transl Int Med 2018 Dec 31;6(4):159-164. Epub 2018 Dec 31.

Department of Hematology, First Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China.

Aplastic anemia (AA) is a common hematologic disease that is characterized by hematopoietic failure of the bone marrow and pancytopenia of the peripheral blood, which can be divided into severe and non-severe aplastic ane-mia, or acute and chronic aplastic anemia according to the severity of the disease and the progress of the clinical course. During the past years, the advantages of Traditional Chinese Medicine (TCM) on the treatment of AA have been well clarified and its theory system has been improved as well. This review is mainly on representing the pathogenesis, therapeutic principle and method, research progression, and advantages of TCM on AA. Read More

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http://dx.doi.org/10.2478/jtim-2018-0031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326026PMC
December 2018

Prevalence of anemia among adults at Hawassa University referral hospital, Southern Ethiopia.

BMC Hematol 2019 8;19. Epub 2019 Jan 8.

2School of Nursing and Midwifery, Hawassa University College of Medicine and Health Sciences, Hawassa, Ethiopia.

Introduction: Anemia is a public health problem in Ethiopia. In spite of the fact that anemia is a common health burden with much severe consequences, the prevalence of the different types of anemia and its severity have not yet been well documented in different parts of the country. The study aimed to assess the prevalence of different types of anemia, including severity and association with age and sex of study population. Read More

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http://dx.doi.org/10.1186/s12878-018-0133-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323856PMC
January 2019

[Lead intoxication revealing sickle cell disease].

Pan Afr Med J 2018 31;30:305. Epub 2018 Aug 31.

Service de Rhumatologie, CHU Mohammed VI, BP 2360 principal, Avenue Ibn Sina, Marrakech, Maroc.

We here report the case of a 18 year old patient with two brothers who died from sickle cell anemia. He had a 5-day history of diffuse bone pain. He had drunk a preparation containing lead to obtain an analgesic effect without improvement. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.305.16222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320453PMC

[Study of fetal heart rate abnormalities observed on cardiotocography in Lubumbashi: about a cases followed at the Lubumbashi University Clinic and the General Hospital of the Cinquantenaire].

Pan Afr Med J 2018 17;30:278. Epub 2018 Aug 17.

Département de Gynécologie-Obstétrique de la Faculté de Médecine de l'Université de Lubumbashi, Republique Démocratique du Congo.

Cardiotocography (CTG) has recently come into use in Lubumbashi but no thorough study has yet been conducted to identify its impact on perinatal morbi-mortality. This study aims to determine the frequency of fetal heart rate abnormalities (FHR)in order to identify the associated factors and to propose a suitable management. We conducted a cross-sectional, descriptive study of 411 women in labour over a period of 19 months (March 2015-December 2016). Read More

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http://dx.doi.org/10.11604/pamj.2018.30.278.13365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317385PMC

Obstetric admissions to tertiary level intensive care unit - Prevalence, clinical characteristics and outcomes.

Indian J Anaesth 2018 Dec;62(12):940-944

Department of Obstetrics and Gynaecology, CMC and Hospital, Ludhiana, Punjab, India.

Background And Aims: Obstetric admissions to the intensive care unit (ICU) are a subject of increasing interest, as it is an indirect indicator of maternal morbidity and mortality. The studies from areas reported to have a higher maternal mortality rate are lacking. Thus, we undertook this study to determine the prevalence pattern, clinical characteristics and outcome of obstetric patients admitted to the ICU of a tertiary care hospital. Read More

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http://dx.doi.org/10.4103/ija.IJA_537_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299771PMC
December 2018