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Andrology 2019 Apr 19. Epub 2019 Apr 19.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), Porto, Portugal.

Background: The human leukocyte antigen (HLA) locus includes several genes with key roles in antigen presentation and immune response, some of them inclusively found to be associated with non-obstructive azoospermia. Still, HLA connections to other infertility phenotypes such as semen hyperviscosity (SHV), asthenozoospermia (AST), and oligozoospermia (OLI) have been often neglected.

Objectives: In this work, we aimed to evaluate the association of HLA class I and II genes with SHV, AST, and OLI phenotypes while exploring a possible role in an adaptive immune response to sexually transmitted diseases (STD). Read More

Andrology 2019 Apr 19. Epub 2019 Apr 19.

Departamento de Biología de la Reproducción Dr. Carlos Gual Castro, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

Background: Plasma membranes of ejaculated sperm are covered by epididymal and accessory glands secreted proteins that must be released from sperm surface during the female reproductive tract passage in order to capacitate and fertilize the oocyte.

Objectives: As human sperm plasma membrane-associated proteins (SMAP) have not yet been investigated, the aim of this study was to characterize the SMAP released during in vitro human capacitation and to study their possible role as decapacitation factors.

Materials And Methods: SMAP were characterized by 2-dimensional electrophoresis and mass spectrometry analysis. Read More

Andrology 2019 Apr 19. Epub 2019 Apr 19.

Research Program in Men's Health: Aging and Metabolism, The Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.

Background: We have shown that testosterone administration suppresses hepcidin, stimulates iron-dependent erythropoiesis, and increases hemoglobin and hematocrit.

Objective: We investigated whether testosterone-mediated suppression of hepcidin plays an essential role in mediating testosterone's stimulatory effects on erythropoiesis.

Methods: We utilized two mouse models to elucidate the role of hepcidin as a mediator of testosterone's effects on erythropoiesis: First, we used a whole-body hepcidin knockout (HepKO) mouse. Read More

Andrology 2019 Apr 16. Epub 2019 Apr 16.

Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.

Background: Nowadays, serodiscordant couples (SDCs) with human immunodeficiency virus (HIV) or hepatitis C virus (HCV)-infected men have the chance to conceive safely, giving birth with a minimum risk of cross-infection.

Objective: To assess the impact of male HIV and HCV infection on the assisted reproductive technologies (ART) outcomes in SDCs, with HIV or HCV seropositive men and negative partners.

Materials And Methods: Of 153 couples: 24 in Group 1 (HIV-seropositive men), 60 in Group 2 (HCV-seropositive men) and 69 in Group 3 (controls). Read More

Andrology 2019 Apr 10. Epub 2019 Apr 10.

Department of Medicine, Division of Endocrinology, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA.

Background: Novel male-based contraceptives are needed to broaden family planning choices. A progestin, Nestorone (Nes) gel, plus a testosterone (T) gel suppresses sperm concentrations to levels associated with effective contraception in normal men. However, administration of two gels on different parts of the body daily is impractical. Read More

Andrology 2019 Apr 10. Epub 2019 Apr 10.

Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Determining stage and anticipating prognosis are the two crucial steps after the diagnosis of a germ-cell cancer that both guide subsequent treatment decisions. This review focuses on metastatic disease, which means germ-cell cancers beyond stage I limited to the testis. In the past, major centers developed separate staging and prognostic classifications for metastatic germ-cell cancer, which heavily impaired communication and comparisons across clinical trials. Read More

Andrology 2019 Apr 10. Epub 2019 Apr 10.

Department of Andrology and Sexual Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background: The correlation between the increased mean platelet volume and varicocele is controversial.

Objectives: We designed this research to demonstrate the correlation relationship between varicocele and mean platelet volume by studying the changes of mean platelet volume in patients with varicocele before and after operation.

Materials And Methods: A total of 317 patients with left unilateral varicocele underwent operation, and 293 healthy adult males were enrolled in the study. Read More

Andrology 2019 May 5;7(3):288-292. Epub 2019 Apr 5.

Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M University, College Station, TX, USA.

Background: Studies have suggested that rapid age-related declines of testosterone (T) level may play a critical role in the development of prostate cancer (PCa), and family history of PCa is another well-established risk factor of PCa, which have been reported to be associated with androgen metabolism-related genes. However, few studies have ever investigated whether a family history of PCa influences the risk of PCa via regulating the age-related trend of T level among males over the life course.

Objectives: To examine the association between family history of PCa and age-related trend of T levels. Read More

Andrology 2019 Apr 1. Epub 2019 Apr 1.

Lin He's Academician Workstation of New Medicine and Clinical Translation at The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Background: Previous studies suggested that sperm head shape may serve as an effective indicator of semen quality. However, there lacks research with large sample and quantitative measurement.

Objectives: The objective of this retrospective study was to explore the association between sperm head elongation (Width/Length ratio) and routine semen parameters. Read More

Andrology 2019 Mar 29. Epub 2019 Mar 29.

Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.

Background: Spermatozoa become competent for fertilization during transit through the epididymis. As spermatozoa from the proximal caudal epididymis can fertilize eggs, proteins from the caput and corpus epididymis are required for sperm maturation.

Objectives: Microarray analysis identified that more than 17,000 genes are expressed in the epididymis; however, few of these genes demonstrate expression restricted to the epididymis. Read More

Andrology 2019 Mar 29. Epub 2019 Mar 29.

Department of Urology, Urological Research Lab, Translational Urooncology, University Medical School Duesseldorf, Duesseldorf, Germany.

Background: Type II germ cell tumors represent the most common solid malignancy in men aged 15-45 years. Despite high cure rates of >90% over all stages, 10-15% of advanced patients develop treatment resistance and potentially succumb to their disease. Treatment of refractory germ cell tumors remains unsatisfactory, and new approaches are needed to further improve outcomes. Read More

Andrology 2019 Mar 29. Epub 2019 Mar 29.

Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: Testicular cancer (TC) is the most common cancer diagnosed in men of reproductive age group. Sperm banking is recommended in these patients prior to cancer treatment. There is no literature describing the proteins dysregulated in the spermatozoa of TC patients with poor motility. Read More

Andrology 2019 May 28;7(3):373-381. Epub 2019 Mar 28.

Department of Animal Reproduction, School of Veterinary Medicine, University of São Paulo, Avenida Professor Doutor Orlando Marques de Paiva, Sao Paulo, Brazil.

Background: Sperm DNA integrity is crucial for transmission of genetic information to future generations and DNA damage can occur during chromatin packaging. Chromatin packaging involves the replacement of somatic nucleosomal histones by nuclear proteins called protamines. Protamine 1 (PRM1) is transcribed and translated in spermatids of all mammals; however, protamine 2 (PRM2) is transcribed in low levels in spermatids and it is not yet described in bull mature spermatozoa. Read More

Andrology 2019 Mar 28. Epub 2019 Mar 28.

Institute for Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany.

Background: The transcription factor DMRTB1 plays a pivotal role in coordinating the transition between mitosis and meiosis in murine germ cells. No reliable data are available for human testis.

Objectives: The present study aims to examine the testicular expression pattern of DMRTB1 in men showing normal and impaired spermatogenesis. Read More

Andrology 2019 Mar 28. Epub 2019 Mar 28.

Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

Background: Humanin has reportedly been expressed in testis and spermatozoa, but no study has yet reported its presence in human seminal plasma (SP).

Objective: The aim of this study was to investigate the presence of humanin in human SP and to determine the correlation between humanin levels in SP/spermatozoa and sperm quality.

Materials And Methods: Semen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation. Read More

Andrology 2019 May 27;7(3):293-301. Epub 2019 Mar 27.

IVI VALENCIA, Valencia, Spain.

Background: Sperm vitrification (V) is a method for cryopreservation, without the use of conventional cryoprotectants, by plunging the sperm suspension directly into liquid nitrogen (LN25).

Objective: This study aimed to compare the new system of V with conventional freezing (CF) protocol using fresh spermatozoa as reference (C).

Material And Methods: Prospective cohort study. Read More

Andrology 2019 Mar 25. Epub 2019 Mar 25.

Department of Veterinary, Universidade Federal de Viçosa, Viçosa, MG, Brazil.

Background: Bulls are of great importance in the productive chain and for this reason they should have a good semen quality. There is no doubt that sperm morphology is very important to bull fertility, although little is known about how exactly the abnormal morphologies may affect sperm functions.

Objectives: To detail the morphological description of the aplastic midpiece defect (AMD), as well as to understand its consequences for male fertility based on membrane and acrosome status, mitochondrial membrane potential and DNA integrity parameters. Read More

Andrology 2019 Mar 23. Epub 2019 Mar 23.

Department of Developmental Pathology, Institute of Pathology, Bonn University Medical School, Bonn, Germany.

Background: Type II testicular germ cell tumors (GCTs) arise from a common precursor lesion (germ cell neoplasia in situ) and are stratified into seminomas and non-seminomas, which differ considerably in morphology, gene expression, and epigenetic landscape. The N6-methyladenosine (6mA) epigenetic modification is the most abundant modification in mRNA and is also detectable in eukaryotic DNA. The functional role of 6mA is not fully understood, but 6mA residues may influence transcription by affecting splicing, miRNA processing, and mRNA stability. Read More

Andrology 2019 Mar 21. Epub 2019 Mar 21.

Department of Pediatrics, Division of Hematology/Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

Background: Testicular germ cell tumors (GCTs) represent the most common malignancy in young men. While GCTs represent a model for curable solid tumors due to exquisite chemosensitivity, mortality for patients with GCT comprises the most life years lost for non-pediatric malignancies. Given limited options for patients with platinum-resistant disease, improved insight into GCT biology could identify novel therapeutic options for patients with platinum-resistant disease. Read More

Andrology 2019 Mar;7 Suppl 1:1-110

Andrology 2019 May 19;7(3):341-349. Epub 2019 Mar 19.

Department of Surgery, Division of Urology, Human Reproduction Section, Sao Paulo Federal University, Sao Paulo, Brazil.

Background: Previous studies have demonstrated an association between obesity and the decreased male fertility.

Objective: to observe the mechanisms by which obesity affects semen quality.

Materials And Methods: A prospective study was performed including 47 male volunteers, of which 27 were obese group (body mass index >30 kg/m ) and 20 were eutrophic (body mass index between 18. Read More

Andrology 2019 May 10;7(3):273-280. Epub 2019 Mar 10.

Division of Obstetrics & Gynaecology, The University of Western Australia, Perth, WA, Australia.

Background: Controversial speculation suggestions that dietary intake may affect semen quality and testicular function, however, there are limited comprehensive studies observing dietary patterns.

Objective: To study associations between major dietary patterns and markers of testicular function in adulthood.

Material And Methods: Observational cross-sectional study of two hundred and ninety men with an average age of 20 years, from the Western Australian Pregnancy Cohort (Raine) Study. Read More

Andrology 2019 May 8;7(3):302-306. Epub 2019 Mar 8.

Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium.

Background: Congenital hypogonadotropic hypogonadism (CHH) is a rare condition characterized by complete sex steroid deficiency. Therefore, CHH is a unique human model to study the impact of long-term testosterone replacement therapy (TRT) on bone.

Objective: In this single-center retrospective observational study, we assessed the long-term impact of TRT on femoral and lumbar bone mineral density (BMD) in adult CHH men. Read More

Andrology 2019 May 27;7(3):329-340. Epub 2019 Feb 27.

IVF Center, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Congenital absence of vas deferens (CAVD) is a major cause of obstructive azoospermia. Mutations in CFTR and ADGRG2 are responsible for this disease. However, until now the genetic spectrum of the CFTR and ADGRG2 genes in Chinese population and the reasons of the differences from Caucasian cohorts were not clear. Read More

Andrology 2019 Mar 22;7(2):131-138. Epub 2019 Feb 22.

Center of Reproductive Medicine and Andrology, Department of Clinical and Surgical Andrology, Institute of Reproductive and Regenerative Biology, Münster, Germany.

Background: It is commonly accepted that testicular function is prevalently regulated by the hypothalamic-pituitary-gonadal axis: The pulsatile secretion of GnRH by the hypothalamus induces pituitary expression of the two gonadotropins FSH and LH, which then stimulate Sertoli and Leydig cells, respectively, therefore regulating steroidogenesis and spermatogenesis. However, a growing body of evidence has recently suggested that other hormones act on the reproductive tract since the early phases of fetal development. Anti-Müllerian hormone and INSL3 are still largely used only for research purposes despite being increasingly recognized as markers of Sertoli and Leydig cells function, respectively. Read More

Andrology 2019 May 22;7(3):357-372. Epub 2019 Feb 22.

Reproduction, Mother and Child Health, Centre de Recherche du CHU de Québec-Université Laval, Quebec, QC, Canada.

Background: GATA4 is a transcription factor essential for male sex determination, testicular differentiation during fetal development, and male fertility in the adult. GATA4 exerts part of its function by regulating multiple genes in the steroidogenic enzyme pathway. In spite of these crucial roles, how the activity of this factor is regulated remains unclear. Read More

Andrology 2019 May 21;7(3):382-390. Epub 2019 Feb 21.

Unit for Reproductive Medicine of Clinics/Clinic for Pigs and Small Ruminants, University of Veterinary Medicine Hannover, Hannover, Germany.

Background: Knowledge on the effect of seminal plasma on sperm function in extended semen during in vitro storage is lacking.

Objectives: The aim was to examine the interactive role of sperm concentration and seminal plasma concentration on boar sperm function during in vitro aging.

Material And Methods: Experiment 1: Twenty-one boar ejaculates were aliquoted with Beltsville Thawing Solution into five semen doses containing between 32. Read More

Andrology 2019 May 20;7(3):319-328. Epub 2019 Feb 20.

Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.

Background: Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) is a Golgi protein that plays a role in vesicular transport and intracellular protein trafficking and degradation. Mice deficient in GOPC protein have globozoospermia and are infertile. The germ cell nuclear factor (GCNF) is a member of the nuclear receptor superfamily which is expressed in male germ cells, from spermatocytes and spermatids, both in the nucleus and the acrosomal region. Read More

Andrology 2019 May 20;7(3):267-272. Epub 2019 Feb 20.

Departamento de Cirurgia, Universidade Federal de Pernambuco, Recife, Brazil.

Background: Human fertility has always been a topic of curiosity and devotion. Many cultures consider fertility to be a necessity for the survival and perpetuation of mankind and since early times, myths were created to explain this fabulous process. Fertility gods were ubiquitous in numerous ancient human cultures and were used both to understand fertility and to cope with infertility by means of rituals and offerings. Read More

Andrology 2019 Feb 20. Epub 2019 Feb 20.

Massachusetts General Hospital, Boston, MA, USA.

Background: While the spermatotoxic properties of cancer treatments such as chemotherapy and radiation therapy are widely recognized, the effect of malignancy itself on male fertility is not clearly understood.

Objectives: To determine whether malignancy is associated with diminished semen quality prior to spermatotoxic treatment among sperm bankers.

Materials And Methods: Retrospective database review of de-identified records was obtained for all episodes of sperm banking performed at a cryobank from January 2004 to May 2017 for one of the following reasons: 'future use' (e. Read More

Andrology 2019 Feb 20. Epub 2019 Feb 20.

Pathology (LEPO), Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.

Background: The microRNA-371a-3p (miR-371a-3p) has been reported to be an informative liquid biopsy (serum and plasma) molecular biomarker for both diagnosis and follow-up of patients with a malignant (testicular) germ cell tumor ((T)GCT). It is expressed in all histological cancer elements, with the exception of mature teratoma. However, normal testis, semen, and serum of males with a disrupted testicular integrity without a TGCT may contain miR-371a-3p levels above threshold, of which the cellular origin is unknown. Read More

Andrology 2019 May 20;7(3):350-356. Epub 2019 Feb 20.

Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Background: Reproductive toxicity of lipopolysaccharide (LPS) on spermatozoa is well established.

Objective: The aim of the present study was to show the potential benefits of alpha lipoic acid (ALA) as a strong antioxidant in alleviating the reproductive toxicity of LPS.

Materials And Methods: Sperm cells and cumulus-oocyte complexes (COCs) were collected from healthy NMRI mice (body weights ranged from 25 to 35 g, 100 females and 200 males). Read More

Andrology 2019 May 19;7(3):315-318. Epub 2019 Feb 19.

Department of Reproductive Medicine, Toulouse University Hospital, Toulouse, France.

Background: Cryopreservation is used for infertility treatment and for fertility preservation. The results of the use of frozen spermatozoa for ART (Assisted Reproductive Technology) are lower than those of fresh spermatozoa. The phospholipase C Zeta (PLCζ) protein is involved in oocyte activation. Read More

Andrology 2019 Mar 15;7(2):139-147. Epub 2019 Feb 15.

Department of Urology, University of Washington Medical Center, Seattle, WA, USA.

Background: In the United States of America (USA), cannabis is legal in 28 states for medical purposes and 8 states for recreational use. In 2016, the legal marijuana industry reached nearly $7 billion in sales in the USA alone. Although consumption continues to increase, the medical effects of marijuana remain understudied. Read More

Andrology 2019 May 13;7(3):307-314. Epub 2019 Feb 13.

Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: The relation between endogenous testosterone concentrations and myocardial mass and function remains incompletely understood.

Objectives: To determine the cross-sectional association between endogenous hormone levels with cardiac magnetic resonance measures of myocardial mass, structure, and function in community-dwelling men across a wide age range.

Methods: A total of 720 men from the Framingham Heart Study Offspring Cohort (age range 37-82, mean = 59. Read More

Andrology 2019 May 7;7(3):281-287. Epub 2019 Feb 7.

MUHC Reproductive Centre, McGill University Health Centre, Montreal, QC, Canada.

Background: The use of testicular over ejaculated spermatozoa for ICSI has been presented as an alternative to overcome infertility in men with poor semen parameters or high levels of sperm DNA fragmentation.

Objective: To evaluate the efficacy of testicular ICSI outcomes in couples with no previous live birth and recurrent ICSI failure using ejaculated spermatozoa by comparison to the outcomes of couples with similar history of recurrent ICSI using ejaculated spermatozoa only.

Materials And Methods: A total of 145 couples undergoing ejaculated or testicular ICSI cycles with no previous live births and with at least two previous failed ICSI cycles with ejaculated spermatozoa were evaluated retrospectively. Read More

Andrology 2019 Jan;7(1)

Departments of Surgery (Andrology and IVF) and Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA.

Andrology 2019 Jan;7(1):124-130

Andrology 2019 Mar 3;7(2):178-183. Epub 2019 Feb 3.

Department of Urology, Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.

Background: Several studies have linked vasectomy with the risk of prostate cancer; however, this association has been attributed to selection bias. Since vasectomy is a common and effective form of contraception, these implications are significant. Therefore, we sought to test this association in a large observational cohort. Read More

Andrology 2019 Mar 21;7(2):148-155. Epub 2019 Jan 21.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.

Background: The association between low testosterone concentration and increased risk of hyperglycemia in men has been demonstrated in observational and interventional studies. However, considering a variety of confounding factors, limited population-based studies have so far been conducted. Also, no information is available regarding the effect of testosterone on progressive development of dysglycemia. Read More

Andrology 2019 Mar 20;7(2):156-162. Epub 2019 Jan 20.

Dipartimento Donna-Bambino-Neonato, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Several diet patterns have been suggested as involved in processes of spermatogenesis and thus in male subfertility. To study the relation between Mediterranean diet and abnormal sperm parameters in men of subfertile couples, we performed a cross-sectional analysis of baseline data from a prospective cohort study.

Methods: Patients were enrolled in an Italian Fertility Clinic. Read More

Andrology 2019 Mar 20;7(2):228-234. Epub 2019 Jan 20.

Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Background: Toll-like receptors play a crucial role in the immunological interaction between the spermatozoa and fallopian tube and contribute to the ovulation, sperm capacitation, fertilization, and pregnancy.

Objectives: To investigate the expression of toll-like receptors and their adaptor molecules and cytokines under the effect of spermatozoa with high DNA fragmentation (high DF) in human fallopian tube cell line (OE-E6/E7) and compare to those in normal spermatozoa.

Materials And Methods: Fresh semen samples were obtained from 10 unexplained infertile males with high DF (more than 20%) and from 10 healthy donors with a DF less than 3%. Read More

Andrology 2019 Jan 20. Epub 2019 Jan 20.

Cancer and Chronic Conditions (C3) Research Group, Department of Public Health, University of Otago, Wellington, New Zealand.

Background: Testicular germ cell tumour is the most common cancer to be diagnosed among young men. In New Zealand, we have observed some puzzling trends in the epidemiology of this disease.

Methods: We have conducted a narrative review of available evidence regarding the puzzling epidemiology of testicular germ cell tumour in New Zealand and discussed the possible drivers of these trends. Read More

Andrology 2019 Jan 20. Epub 2019 Jan 20.

Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Background: We previously demonstrated the normal mouse epididymal lumen contains a non-pathological amyloid matrix that surrounds spermatozoa and plays important roles in sperm maturation and protection.

Objective: The objective herein was to present a review of this work, including studies showing the amyloid structures of four members of the CRES (cystatin-related epididymal spermatogenic) subgroup are integral and essential components of the amyloid matrix.

Methods: We used conformation-dependent reagents that recognize the cross-β-sheet structure characteristic of amyloid, including thioflavin S (ThS), thioflavin T (ThT), anti-amyloid antibodies, and X-ray diffraction, as well as negative-stain transmission electron microscopy (TEM) to visualize amyloid structures in the epididymal lumen. Read More

Andrology 2019 Mar 18;7(2):251-256. Epub 2019 Jan 18.

Department of Clinical and Experimental Sciences, Unit of Endocrinology, University of Brescia, Brescia, Italy.

Background: Copy number variations (CNVs) play an important role in the onset of several diseases, and recently research focused on the relationship between these structural variants and diseases of the reproductive tract, including male infertility and cryptorchidism.

Objectives: To evaluate the contribution of copy number variations of E2F1 gene to idiopathic male infertility and the factors influencing expression of this gene.

Materials And Methods: We performed a retrospective study on 540 subjects recruited from September 2014 to February 2015. Read More

Andrology 2019 Mar 7;7(2):193-198. Epub 2019 Jan 7.

Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: There is wide agreement nowadays that a clinical varicocoele should be ligated to treat male factor infertility. However, the significance of testicular artery preservation in patients with severe oligozoospermia has not been addressed before.

Objectives: To assess the outcome of varicocelectomy in infertile men with severe oligozoospermia and clinical varicocoeles and to compare internal spermatic artery preservation vs. Read More

Andrology 2019 Mar 4;7(2):184-192. Epub 2019 Jan 4.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Background: The clinical value of perineural invasion (PNI) in patients with localized prostate cancer (PCa) is widely explored. However, its role in metastatic PCa (mPCa) remains unknown.

Objectives: We aim to investigate the clinical significance of PNI in patients with mPCa. Read More

Andrology 2019 Jan 4. Epub 2019 Jan 4.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Primary hypogonadism (low testosterone and high luteinizing hormone, LH) is present in approximately 20% of testicular cancer (TC) survivors after orchidectomy with or without chemotherapy.

Objectives: We investigated insulin-like factor 3 (INSL3), a novel marker of Leydig cell function, in TC patients.

Materials And Methods: We analyzed: (I) a cross-sectional cohort of TC patients after orchidectomy with or without chemotherapy (1988-1999) at long-term follow-up (median 36 and 35 years of age at follow-up, respectively) and healthy men of similar age; (II) a longitudinal cohort of chemotherapy-treated TC patients (2000-2008), analyzed before and 1 year after chemotherapy (median 29 years of age at chemotherapy). Read More

Andrology 2018 Dec 21. Epub 2018 Dec 21.

Cancer Registry of North Rhine-Westphalia, Muenster, Germany.

Background: In 2016, the WHO introduced an updated classification for testicular tumors. The application of this updated classification to cancer registry data requires some recoding of tumors.

Objectives: The aim of this study was to provide up-to-date population-based incidence estimates of subtypes of testicular germ cell tumors (TGCT) according to the updated classification. Read More

Andrology 2019 Mar 21;7(2):220-227. Epub 2018 Dec 21.

Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.

Background: Semenogelin 1 (SEMG1) is an important secretory protein in spermatozoa involved in the formation of a gel matrix encasing ejaculated spermatozoa. Previous studies show that the SEMG1 gene is highly expressed in spermatozoa from patients with asthenozoospermia (AZS); however, the underlying molecular mechanisms are not yet clear.

Objectives: To study the molecular mechanism of high expression of SEMG1 gene and its potential roles in AZS. Read More