4,220 results match your criteria Andrologia[Journal]


Oxidative stress-related miRNAs in spermatozoa may reveal the severity of damage in grade III varicocele.

Andrologia 2020 Jun 1:e13598. Epub 2020 Jun 1.

Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Varicocele is associated with excessive production of reactive oxygen species (ROS). Although the harmful effects of ROS on sperm DNA, proteins and lipids are well documented, its impact on the expression of miRNAs in spermatozoa has not been fully understood. In this study, the expression patterns of microRNAs (miRNAs), miR-21, miR-34a and miR-122a as well as the level of ROS in the fertile control (FC; proven fertility without varicocele, n = 15) and grade III varicocele patients with normal (VN; n = 15) and abnormal (VA; n = 15) spermogram were investigated. Read More

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http://dx.doi.org/10.1111/and.13598DOI Listing

Compound heterozygosity for novel AURKC mutations in an infertile man with macrozoospermia.

Andrologia 2020 Jun 1:e13663. Epub 2020 Jun 1.

Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Among causes of infertility, teratozoospermia is characterised by a percentage of morphologically abnormal spermatozoa >4%. Macrozoospermia, one form of monomorphic teratozoospermia, is observed in <1% of cases of male infertility and is described as approximately 100% large-headed and/or multitailed spermatozoa. This study reports that an infertile man with large-head spermatozoa presenting compound heterozygosity aurora kinase C (AURKC) mutations (c. Read More

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http://dx.doi.org/10.1111/and.13663DOI Listing

Maternal CBZ exposure impairs testicular development, spermatogenesis and sperm parameters in male offspring at puberty.

Andrologia 2020 Jun 1:e13657. Epub 2020 Jun 1.

Department of Morphology and Genetics, Developmental Biology Laboratory, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.

Carbamazepine (CBZ), an anticonvulsant drug, is used by pregnant women and crosses the placental barrier, reaching the embryo/foetus. CBZ inhibits testicular steroidogenesis and may lead to alterations in testicular development, spermatogenesis and male fertility. The purpose of this study was to evaluate the CBZ effects on testicular parameters in the neonatal and pubertal phases, as well as the spermatic parameters of pubertal rats, originated from dams treated during different periods of the pregnancy. Read More

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http://dx.doi.org/10.1111/and.13657DOI Listing

Investigation of cholestasis-related changes in characteristics of spermatogonial stem cells in testis tissue of male Wistar rats.

Andrologia 2020 Jun 1:e13660. Epub 2020 Jun 1.

Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.

Paternal metabolic status is an important factor in the health status of offspring. Cholestasis, as a metabolic disorder, significantly disrupts spermatogenesis. Spermatogonial stem cells (SSCs) are considered the dividing germ cells, which maintain spermatogenesis throughout the lifespan. Read More

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http://dx.doi.org/10.1111/and.13660DOI Listing

Melatonin prevents deterioration of erectile function in streptozotocin-induced diabetic rats via sirtuin-1 expression.

Andrologia 2020 Jun 1:e13639. Epub 2020 Jun 1.

Department of Urology, School of Medicine, Marmara University, Istanbul, Turkey.

A review of the literature indicated that sirtuin-1 expression, a regulator of nitric oxide bioavailability in erectile dysfunction (ED) after melatonin therapy, has not yet been investigated. The objective of this study was to evaluate the protective effects of melatonin for erectile function with sirtuin-1 protein expression in type 1 diabetic rat models. Fifty male Sprague Dawley rats were placed into five groups. Read More

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http://dx.doi.org/10.1111/and.13639DOI Listing

Measurement of serum glutathione peroxidase, catalase and superoxide dismutase concentration in patients with external anogenital warts before and after treatment with intralesional tuberculin purified protein derivative.

Andrologia 2020 Jun 1:e13661. Epub 2020 Jun 1.

Department of Andrology, Infertility and Sexually Transmitted Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

External anogenital warts are considered the commonest viral sexually transmitted infection that has serious negative psychological effects on both males and females such as anxiety and marked stress. Aim of this work is to measure serum glutathione peroxidase (GSH-Px), catalase and superoxide dismutase enzyme level in patients with external anogenital warts before and after intralesional tuberculin purified protein derivative (PPD) injection. This study carried out 59 patients with anogenital warts recruited from the dermatology clinic and the andrology clinic, Suez Canal University hospital. Read More

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http://dx.doi.org/10.1111/and.13661DOI Listing

Effects of liver-regulating herb compounds on testicular morphological and ultrastructural changes in varicocele rats through SCF/C-KIT pathway.

Andrologia 2020 Jun 1:e13658. Epub 2020 Jun 1.

Reproductive Medicine Department, Shanxi Provincial People's Hospital Affiliated of Shanxi Medical University, Taiyuan, China.

Liver-regulating herb compound (LRHC) has good effects on improving sperm quality and male fertility of varicocele (VC) patients. But the mechanism of LRHC on VC is still not clear. This study explored the effects of LRHC on histomorphological and ultrastructural changes and expression of stem cell factor (SCF) and C-KIT of VC rat testis. Read More

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http://dx.doi.org/10.1111/and.13658DOI Listing

Evaluation of synergic effects of iodixanol and trehalose on cryosurvival of electroejaculated ram semen.

Andrologia 2020 Jun 1:e13656. Epub 2020 Jun 1.

Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Istanbul University, Istanbul, Turkey.

The primary aim of the study was to investigate whether iodixanol and trehalose would have a synergic effect on the cryosurvival of electroejaculated ram semen. Tris-based diluter was used to prepare 9 different extenders by the addition of iodixanol or trehalose alone or varying combinations of these substances. Diluters were prepared as follows: Tris (control), Io5 (5% iodixanol), Tr25 (25 mmol/L trehalose), Tr50 (50 mmol/L trehalose), Tr50 + Io1. Read More

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http://dx.doi.org/10.1111/and.13656DOI Listing

Identification and verification of key genes in varicocele rats through high-throughput sequencing and bioinformatics analysis.

Andrologia 2020 May 27:e13662. Epub 2020 May 27.

Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.

Varicocele (VC) is the most common treatable cause of infertility, but it is difficult to distinguish fertile from infertile VC populations because the pathogenesis is unclear. In order to study the related mechanism of VC causing male sterility, we made VC rat model by surgery, analysed the rat epididymal spermatozoa and used the transcriptome sequencing to compare all the mRNA expression differences in testicular tissue between VC rats and control rats. The differentially expressed genes (DEGs) of testicular tissue were also screened by the limma package in R software (version 3. Read More

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http://dx.doi.org/10.1111/and.13662DOI Listing

A randomised trial comparing conventional semen parameters, sperm DNA fragmentation levels and satisfaction levels between semen collection at home and at the clinic.

Andrologia 2020 May 26:e13628. Epub 2020 May 26.

Center of Assisted Reproduction and Embryology, The University of Hong Kong - Shenzhen Hospital, Shenzhen, China.

The aim of the randomised trial was to compare conventional semen parameters, sperm DNA fragmentation levels and satisfaction levels between semen samples collected at home and at the clinic. We recruited 110 men with a history of infertility for at least 1 year from the outpatient andrology clinic. Each man collected two semen samples, one at home and one at the clinic. Read More

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http://dx.doi.org/10.1111/and.13628DOI Listing

Acute effect of microdissection testicular sperm extraction on blood total testosterone and luteinising hormone levels.

Andrologia 2020 May 26:e13655. Epub 2020 May 26.

Department of Urology, SBU Okmeydanı SUAM, Istanbul, Turkey.

Testicular sperm extraction is a common surgical procedure to retrieve spermatozoa from men with azoospermia which may affect the tissue and cause hypogonadism (Human Reproduction Update, 24, 2018, 442). We aimed to evaluate the acute effect of micro-TESE on blood total testosterone (TT) and luteinising hormone (LH) levels. Between April 2018 and September 2019, 60 selected NOA (i. Read More

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http://dx.doi.org/10.1111/and.13655DOI Listing

Diagnostic value of advanced semen analysis in evaluation of male infertility.

Andrologia 2020 May 26:e13625. Epub 2020 May 26.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Conventional semen analysis is the standard of care to initially evaluate the fertility status of a male patient. However, it has some limitations and among these are failure to correctly identify the aetiology underlying fertility problems, intra- and inter-observer variability and incomplete information about sperm function. Considering these drawbacks, advanced semen tests have been developed to assess male infertility, including sperm function tests, oxidative stress (OS) and sperm DNA fragmentation (SDF) tests. Read More

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http://dx.doi.org/10.1111/and.13625DOI Listing

Protein profiling in unlocking the basis of varicocele-associated infertility.

Andrologia 2020 May 26:e13645. Epub 2020 May 26.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Varicocele is one of the major causes of male infertility and has a negative impact on spermatogenesis. The conventional semen analysis does not reveal the underlying subcellular mechanisms associated with defects in spermatozoa. Proteomics and bioinformatics analysis can be used to identify the molecular aetiologies associated with poor semen quality in varicocele patients. Read More

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http://dx.doi.org/10.1111/and.13645DOI Listing

The protective effect of cinnamon and ginger hydro-alcoholic extract on carbon tetrachloride-induced testicular damage in rats.

Andrologia 2020 May 26:e13651. Epub 2020 May 26.

Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Sexual dysfunction of men is one of the most serious problems in human society. This study aimed to evaluate the protective effect of cinnamon and ginger extract on testicular damages induced by carbon tetrachloride (CCl4). Thirty-six male Wistar rats were randomly divided into 6 groups (n = 6): 1. Read More

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http://dx.doi.org/10.1111/and.13651DOI Listing

Evaluation of blood-testis barrier integrity in terms of adhesion molecules in nonobstructive azoospermia.

Andrologia 2020 May 26:e13636. Epub 2020 May 26.

Department of Histology and Embryology, Faculty of Medicine, Ankara University, Ankara, Turkey.

Blood-testis barrier (BTB) is critical for maintaining fertility. The integrity of tight junctions (TJs) provides restricted permeability of BTB. The aim of this study was to evaluate the relationship between BTB and Sertoli cells. Read More

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http://dx.doi.org/10.1111/and.13636DOI Listing

Colonisation of the male reproductive tract in asymptomatic infertile men: Effects on semen quality.

Andrologia 2020 May 26:e13637. Epub 2020 May 26.

Obstetrics Service/Assisted Human Reproduction Unit, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Spain.

The objective was to explore presence/detection of microorganisms in the male reproductive tract (PMMRT) in asymptomatic patients undergoing infertility treatment and their effects on semen quality in our region. This study enrolled 205 men (mean age, 35.9 years) in a single-centre, tertiary university hospital from December 2015 to December 2016. Read More

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http://dx.doi.org/10.1111/and.13637DOI Listing

Carob attenuates nicotine-induced oxidative stress and intratesticular damage in male rats.

Andrologia 2020 May 26:e13670. Epub 2020 May 26.

Department of Anatomy, Faculty of Medicine, Yozgat Bozok Üniversity, Yozgat, Turkey.

In this study, we aimed to evaluate the effect of carob extract against intratesticular histological, apoptotic, biochemical and spermatogenic changes in rats exposed to nicotine. Twenty-eight rats were divided into four groups and were administered saline, nicotine, carob, or nicotine + carob once a day for 35 days. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX), GSH, total anti-oxidative status (TAS), total oxidative status (TOS), oxidative stress index (OSI), IL-6, TNF-α and seminal parameters were evaluated. Read More

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http://dx.doi.org/10.1111/and.13670DOI Listing

Protective effect of Alpha-Linolenic acid on Lipopolysaccharide-Induced Orchitis in mice.

Andrologia 2020 May 26:e13667. Epub 2020 May 26.

Urology Department, Cukurova University Medical Faculty, Adana, Turkey.

Previous studies have demonstrated that polyunsaturated fatty acids (PUFAs) have anti-inflammatory effects. One specific PUFA, alpha-linolenic acid (ALA), shows both anti-inflammatory and antioxidant properties. In the testes, inflammatory mediators are known to increase when orchitis is induced by bacterial lipopolysaccharide (LPS). Read More

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http://dx.doi.org/10.1111/and.13667DOI Listing

Genetic contribution of HIST1H1T regulatory region alternations to human nonobstructive azoospermia.

Andrologia 2020 May 25:e13647. Epub 2020 May 25.

Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

HIST1H1T encodes H1T, a testicular variant of histone H1, which is expressed during spermatogenesis especially in primary spermatocytes and facilitates histone to protamine exchanges during maturation of spermatozoa. The goal of the conducted research was to evaluate four genetic variations of HIST1H1T in men with nonobstructive azoospermia. This case-control study was conducted among a total number of 200 men, including 100 nonobstructive azoospermic (NOA) infertile men. Read More

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http://dx.doi.org/10.1111/and.13647DOI Listing

Environmental contaminants and male infertility: Effects and mechanisms.

Andrologia 2020 May 24:e13646. Epub 2020 May 24.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation and the associated discharge of an excess of synthetic substances into the environment. Humans are inevitably exposed to these ubiquitously distributed environmental contaminants, which possess the ability to intervene with the growth and function of male reproductive organs. Several epidemiological reports have correlated the blood and seminal levels of environmental contaminants with poor sperm quality. Read More

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http://dx.doi.org/10.1111/and.13646DOI Listing

Simultaneous quantification of oestrogens and androgens in the serum of patients with benign prostatic hyperplasia by liquid chromatography-Tandem mass spectrometry.

Andrologia 2020 May 22:e13611. Epub 2020 May 22.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China.

Benign prostate hyperplasia (BPH) is a common disease in elderly men. It has been found that the occurrence of BPH was closely related to dysregulated steroid hormones. Here, a rapid, sensitive, accurate and specific method for the quantitative profiling of five androgens in man serum was developed and validated by the use of liquid chromatography-tandem mass spectrometry (LC-MS/MS). Read More

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http://dx.doi.org/10.1111/and.13611DOI Listing

Comparison of the clinical efficacy of daily use of L-arginine, tadalafil and combined L-arginine with tadalafil in the treatment of elderly patients with erectile dysfunction.

Andrologia 2020 May 22:e13640. Epub 2020 May 22.

Dermatology, Venereology and Andrology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

This study aimed to evaluate the efficacy of the daily oral administrations of L-arginine, tadalafil and combined L-arginine with tadalafil in treatments of elderly patients with erectile dysfunction (ED). It was designed as a single-blind placebo-controlled clinical trial. It was conducted on 120 male patients aged ≥60 years old with ED. Read More

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http://dx.doi.org/10.1111/and.13640DOI Listing

The possible role of NF-κB1 Rs28362491 polymorphism in male fertility of Egyptian population.

Andrologia 2020 May 22:e13659. Epub 2020 May 22.

Department of Biochemistry & Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Male reproductive impairment is responsible for at least 50% of cases of couple infertility. Nuclear factor-kappa B (NF-κB) has been functionally linked to germ cell apoptosis, which may affect human fertility. The aim of this study was to determine the association between the rs28362491 SNP of the NF-κB1 gene and infertility in Egyptian men. Read More

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http://dx.doi.org/10.1111/and.13659DOI Listing

Bipolar enucleation of the prostate-step by step.

Andrologia 2020 May 22:e13631. Epub 2020 May 22.

Department of Urology, Seoul National University Hospital, Seoul, Korea.

Bipolar enucleation of prostate (BipolEP) is a useful method for treatment of benign prostatic hyperplasia (BPH). Compared with conventional transurethral resection, the enucleation technique has several advantages. However, since the cost of laser equipment used for enucleation is relatively high, enucleation using bipolar devices has been attempted by many previous surgeons. Read More

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http://dx.doi.org/10.1111/and.13631DOI Listing

Role of identified noncoding RNA in erectile dysfunction.

Andrologia 2020 May 22:e13596. Epub 2020 May 22.

Hangzhou Xixi Hospital affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

Erectile dysfunction (ED) is a common male sexual dysfunction and is closely related to many risk factors such as age, chronic diseases and mental disorder. Phosphodiesterase type 5 inhibitor (PDE5i) is recommended as the first-line medicine in therapy, but up to 35% of patients fail to this treatment. Unfortunately, the pathogenesis of ED is still poorly understood. Read More

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http://dx.doi.org/10.1111/and.13596DOI Listing

The effect of plasma rich platelet graft on post-operative complications in mid-penile hypospadias.

Andrologia 2020 May 20:e13652. Epub 2020 May 20.

Department of Urology, Yuzuncu Yil University, School of Medicine, Van, Turkey.

Hypospadias is one of the most common penile congenital anomalies, which often requires a surgical approach. After the hypospadias is repaired, urethral fistula can occur in around 20% of patients. In this study, we used platelet-rich plasma (PRP) to reduce the urethral fistula and other post-operative complications after hypospadias repair. Read More

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http://dx.doi.org/10.1111/and.13652DOI Listing

The age-dependent effect of pre-pubertal castration on anxiety-like behaviour in male rats.

Andrologia 2020 May 20:e13649. Epub 2020 May 20.

Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.

Adolescence is considered to be a critical period of sex hormone action (re)organising the brain and determining the behavioural phenotype. Such organisational effects in the brain might be the cause of sex differences in some behavioural features. In this experiment, we aimed to examine the role of pubertal sex hormones in development of anxiety in male rats. Read More

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http://dx.doi.org/10.1111/and.13649DOI Listing

Could COVID-19 have an impact on male fertility?

Andrologia 2020 May 21:e13654. Epub 2020 May 21.

Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Terni, Italy.

The pandemic caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to several hypotheses of functional alteration of different organs. The direct influence of this virus on the male urogenital organs is still to be evaluated. However some hypotheses can already be made, especially in the andrological field, for the biological similarity of the SARS-CoV and SARS-CoV2. Read More

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http://dx.doi.org/10.1111/and.13654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267130PMC

Ziziphus jujube ameliorated cavernosal oxidative stress and fibrotic processes in cavernous nerve injury-induced erectile dysfunction in a rat model.

Andrologia 2020 May 20:e13632. Epub 2020 May 20.

Department of Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.

The aim of this study was to investigate potential antioxidant and antifibrotic effects of Ziziphus jujube (ZJ) in a cavernosal nerve injury (CNI)-induced erectile dysfunction (ED) rat model. Forty-eight male rats were assigned to six-sized groups as group 1: sham-operated; group 2: sham-operated + low-dose ZJ (200 mg/kg); group 3: sham-operated + high-dose ZJ (400 mg/kg); group 4: CNI + distilled water; group 5: CNI + low-dose ZJ; and group 6: CNI + high-dose ZJ. At the end of 2 weeks, intracardiac blood was taken and rats were sacrificed. Read More

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http://dx.doi.org/10.1111/and.13632DOI Listing

Are antioxidants a viable treatment option for male infertility?

Andrologia 2020 May 19:e13644. Epub 2020 May 19.

Department of Urology, Cleveland Clinic Foundation, Cleveland, OH, USA.

Oxidative stress is caused by an imbalance between ROS and antioxidants, which plays a significant role in the pathophysiology of many human diseases. There is extensive evidence highlighting the role of oxidative stress in male infertility due to elevated levels of sperm DNA fragmentation and abnormal semen parameters. The use of antioxidants is a potential therapeutic option to reduce ROS and improve semen quality. Read More

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http://dx.doi.org/10.1111/and.13644DOI Listing

Serum nesfatin-1 is associated with testosterone and the severity of erectile dysfunction.

Andrologia 2020 May 19:e13634. Epub 2020 May 19.

Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

This cross-sectional study aimed to evaluate serum nesfatin-1 concentrations in patients with erectile dysfunction (ED). Patients with ED were selected from the Department of Urology of the Second Affiliated Hospital of Anhui Medical University. The International Index of Erectile Function-5 (IIEF-5) was used to evaluate the severity of ED. Read More

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http://dx.doi.org/10.1111/and.13634DOI Listing

Effects of 3-Heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one alone or/in association with cyclophosphamide on testicular function.

Andrologia 2020 May 15:e13622. Epub 2020 May 15.

Faculdade de Medicina do Mucuri (FAMMUC), Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Teófilo Otoni, Brasil.

Chemotherapy for cancer treatment may result in a temporary or long-term gonadal damage resulting in subfertility or infertility. Cyclophosphamide (CY) is a cytotoxic alkylating agent that has been widely used in the treatment of cancer. Recent studies have shown that synthetic resorcinol lipid AMS35AA (3-Heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one) may be an important adjuvant chemotherapy that potentiates mutagenic damage and increases apoptosis caused by CY. Read More

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http://dx.doi.org/10.1111/and.13622DOI Listing

Anatomical endoscopic enucleation of the prostate: The next gold standard? Yes!

Andrologia 2020 May 13:e13643. Epub 2020 May 13.

Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Anatomical endoscopic enucleation of the prostate (AEEP) differs from other surgical techniques for benign prostatic obstruction (BPO) in that it removes the entire benign prostatic hyperplasia (BPH) component of the prostate. We summarise the main advantages of AEEP compared to other surgical techniques for BPO. These include better urodynamic relief of bladder outlet obstruction, superior outcomes for urinary retention even in the presence of impaired detrusor contractility, safe and effective for any size prostate, and superior durability compared to vaporisation and resection techniques. Read More

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http://dx.doi.org/10.1111/and.13643DOI Listing

Using shear wave elastography method to evaluate testicular compartment syndrome after testicular torsion.

Andrologia 2020 May 13:e13618. Epub 2020 May 13.

Department of Ultrasound, Fujian Medical University Union Hospital, Fuzhou, China.

The measurement of compartment pressure is a direct method to objectively evaluate suspected compartment syndrome. However, to evaluate the evolving compartment syndrome, one needs to measure the pressure repeatedly, which may aggravate the damage of tissue. Despite several suggested approaches, an effective, noninvasive and sustainable method to detect testicular compartment syndrome is still lacking. Read More

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http://dx.doi.org/10.1111/and.13618DOI Listing

The association between androgen receptor splice variant 7 status and prognosis of metastatic castration-resistant prostate cancer: A systematic review and meta-analysis.

Andrologia 2020 May 13:e13642. Epub 2020 May 13.

Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Recent studies have found that metastatic castrated-resistant prostate cancer (mCRPC) with positive androgen receptor splice variant 7 (AR-V7) may have poor prognosis during endocrine or chemotherapy treatment, but the specific mechanism was still unclear. We had finished literature search in March 2019 from PubMed, Web of Science database, and Embase. The final results were presented in this research. Read More

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http://dx.doi.org/10.1111/and.13642DOI Listing

Diagnostic value of routine semen analysis in clinical andrology.

Andrologia 2020 May 12:e13614. Epub 2020 May 12.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Infertility is a major health issue affecting over 48.5 million couples around the world, with the male factor accounting for about 50% of the cases. The conventional semen analysis recommended by the World Health Organization (WHO) is the cornerstone in the evaluation of male fertility status. Read More

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http://dx.doi.org/10.1111/and.13614DOI Listing
May 2020
1.172 Impact Factor

Protective effects of Ranolazine on testicular torsion and detorsion injury in rats.

Andrologia 2020 May 13:e13616. Epub 2020 May 13.

Department of Urology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Ranolazine is a drug used in refractory chronic stable angina. In this study, it was aimed to evaluate the protective effect of ranolazine in a testis torsion model in light of objective biochemical and pathological data. A total of 24 pre-pubertal male Wistar albino rats were separated into three groups of 8 as the sham group, control group and ranolazine group. Read More

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http://dx.doi.org/10.1111/and.13616DOI Listing

Identification of two novel mutations in three Chinese families with Kallmann syndrome using whole exome sequencing.

Andrologia 2020 May 12:e13594. Epub 2020 May 12.

Department of Endocrinology, Central South University, Changsha, China.

Kallmann syndrome (KS) is a rare developmental disorder that manifests as congenital hypogonadotropic hypogonadism with anosmia. More than 19 genes have been found to be associated with KS. However, approximately 70% of the causes of KS remain unclear. Read More

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http://dx.doi.org/10.1111/and.13594DOI Listing
May 2020
1.172 Impact Factor

Total antioxidant capacity-Relevance, methods and clinical implications.

Andrologia 2020 May 12:e13624. Epub 2020 May 12.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Oxidative stress is pre-empted by an adequate level of antioxidants, which scavenge oxidants when they are produced in excess by different sources, including leukocytes and immature spermatozoa. Enzymatic antioxidants, such as superoxide dismutase, catalase and glutathione peroxidase, and several non-enzymatic antioxidants (proteins, vitamins and minerals), working as oxidant scavengers and cofactors of enzymatic antioxidants have been identified in seminal plasma. The total antioxidant capacity (TAC) is a diagnostic test that can be utilised in the male infertility workup. Read More

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http://dx.doi.org/10.1111/and.13624DOI Listing
May 2020
1.172 Impact Factor

Protective effect of vitamin E on sperm parameters in rats infected with Candida albicans.

Andrologia 2020 May 12:e13593. Epub 2020 May 12.

Students Research Committee, Arak University of Medical Sciences, Arak, Iran.

Candida albicans is one of the most frequent pathogens present in the reproductive system. The negative in vitro effects of C. albicans on sperm functions have previously been studied. Read More

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http://dx.doi.org/10.1111/and.13593DOI Listing

How to optimise urinary continence in anatomical endoscopic enucleation of the prostate?

Andrologia 2020 May 13:e13621. Epub 2020 May 13.

S.H. Ho Urology Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

The traditional transurethral resection of the prostate (TURP) is considered as gold-standard surgical treatment to relieve symptoms resulting from bladder outlet obstruction by prostate enlargement. However, with the advances of novel laser technologies and more experienced surgeon conquering the steep learning curve, anatomical endoscopic enucleation of prostate (AEEP) has become a more popular alternative surgical technique. Although AEEP has compatible functional outcome, less blood loss, shorter catheterisation duration and hospital stay, the risk of post-operative urinary incontinence (UI) is often an issue of concern. Read More

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http://dx.doi.org/10.1111/and.13621DOI Listing

Surgical outcome of anatomical endoscopic enucleation of the prostate: A systemic review and meta-analysis.

Andrologia 2020 May 12:e13612. Epub 2020 May 12.

Department of Urology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.

An increasing number of evidences demonstrate the safety and efficacy of endoscopic enucleation of the prostate (EEP) using various energy devices. We performed a systemic literature search for all relevant randomised controlled trials (RCTs) comparing any EEP technique with TURP or open prostatectomy (OP). A total of 21 RCTs with 2,957 patients were included; the majority were studies of holmium laser or bipolar diathermy. Read More

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http://dx.doi.org/10.1111/and.13612DOI Listing

Seminal oxidation-reduction potential levels are not influenced by the presence of leucocytospermia.

Andrologia 2020 May 12:e13609. Epub 2020 May 12.

Male Infertility Unit, Urology Department, Hamad General Hospital, Doha, Qatar.

Oxidative stress (OS) is characterised by an excessive amount of reactive oxygen species (ROS) which negatively affect sperm functions. In this study, the influence of leucocytes on seminal oxidation-reduction potential (ORP) and sperm DNA fragmentation (SDF) was investigated in 1,068 men. Seminal leucocyte concentration did not correlate with SDF, unadjusted ORP, ORP normalised for sperm concentration (sORP), ORP normalised for total motile sperm concentration (motORP) or total motile sperm count (TMSC-ORP). Read More

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http://dx.doi.org/10.1111/and.13609DOI Listing
May 2020
1.172 Impact Factor

Obesity and male infertility: Mechanisms and management.

Andrologia 2020 May 12:e13617. Epub 2020 May 12.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Obesity is considered a global health problem affecting more than a third of the population. Complications of obesity include cardiovascular diseases, type 2 diabetes mellitus, malignancy (including prostatic cancer), neurodegeneration and accelerated ageing. In males, these further include erectile dysfunction, poor semen quality and subclinical prostatitis. Read More

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http://dx.doi.org/10.1111/and.13617DOI Listing
May 2020
1.172 Impact Factor

Mutational analysis of Aurora kinase C gene in Egyptian patients with macrozoospermia.

Andrologia 2020 May 12:e13619. Epub 2020 May 12.

Medical Molecular Genetics Department, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt.

Macrozoospermia is a rare syndrome. The key marker of the disease is a high percentage of spermatozoa with abnormal phenotypes namely enlarged head and multiple tails. The presence of at least 70% of spermatozoa with a large head is usually associated with Aurora kinase C gene (AURKC) mutations. Read More

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http://dx.doi.org/10.1111/and.13619DOI Listing
May 2020
1.172 Impact Factor

Evaluation of seminal Oxidation-Reduction potential in male infertility.

Andrologia 2020 May 12:e13610. Epub 2020 May 12.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

The role of oxidative stress in male infertility has been broadly recognised, and the search for a new marker to determine the redox environment in semen has gained considerable interest. Oxidation-reduction potential (ORP) or redox potential, is a measure of the electron transfer from antioxidants to oxidants and provides information on the redox balance. In this review, the benefits of ORP as a new oxidative stress marker, the protocol for its evaluation and the importance of its measurement in the context of male infertility are discussed. Read More

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http://dx.doi.org/10.1111/and.13610DOI Listing
May 2020
1.172 Impact Factor

Gallic acid and omega-3 fatty acids mitigate epididymal and testicular toxicity in manganese-treated rats.

Andrologia 2020 May 12:e13630. Epub 2020 May 12.

Industrial and Nutritional Biochemistry, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria.

Environmental contamination by manganese is correlated with diverse health outcomes plus reproductive dysfunction. Dietary gallic acid (GA) and omega-3 fatty acids (ω-3-FA) are well reported to elicit beneficial health effects. Though, information on GA and ω-3-FA effects on manganese-induced reproductive toxicity is absent in literature. Read More

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http://dx.doi.org/10.1111/and.13630DOI Listing

Male fertility preservation-Methods, indications and challenges.

Andrologia 2020 May 11:e13635. Epub 2020 May 11.

Fertility and IVF Unit, Department of Obstetrics and Gynecology, Barzilai University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.

Male fertility preservation has been steadily increasing over the past two decades. Significant improvements have been achieved in the treatment modalities of cancer and other severe chronic medical conditions, leading to an increase in patient survivorship and the resulting demand for future parenthood. Recognition and proper patient counselling before commencing therapies with a potential gonadotoxic effect are of paramount importance. Read More

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http://dx.doi.org/10.1111/and.13635DOI Listing

Impact of intra-operative doppler ultrasound assistance during microsurgical varicocelectomy on operative outcome and sperm parameters.

Andrologia 2020 May 7:e13641. Epub 2020 May 7.

Urology Department Lütfi Kirdar Training and Research Hospital, Istanbul, Turkey.

The microsurgical varicocelectomy is the gold standard treatment with a low recurrence rate and less postoperative complications. We compared the surgical outcomes and difficulty in intra-operative vascular Doppler ultrasound-assisted microscopic varicocelectomy (IVDU-MV) with MV in primary and recurrent varicocele. A total of 228 infertile patients with clinically palpable varicocele were included in the study. Read More

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Conventional semen analysis and advanced sperm function tests in diagnosis and management of varicocele.

Andrologia 2020 May 5:e13629. Epub 2020 May 5.

Department of Urology, Cleveland Clinic Foundation, Glickman Urological & Kidney Institute, Cleveland, OH, USA.

Clinical varicoceles are a common cause of male infertility and affect sperm parameters as measured in a conventional semen analysis. Varicocelectomy has been shown in prospective studies to improve semen parameters in men with a clinical varicocele. Clinical varicoceles are also a well-known source of oxidative stress which may affect the quality of spermatozoa. Read More

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http://dx.doi.org/10.1111/and.13629DOI Listing