20,913 results match your criteria Androgenetic Alopecia


Bald thigh syndrome in sighthounds-Revisiting the cause of a well-known disease.

PLoS One 2019 22;14(2):e0212645. Epub 2019 Feb 22.

Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Bald thigh syndrome is a common hair loss disorder in sighthounds. Numerous possible causes, including environmental conditions, trauma, stress, endocrinopathies and genetic components have been proposed, but only endocrinopathies have been ruled out scientifically. The overall goal of our study was to identify the cause of bald thigh syndrome and the pathological changes associated with it. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212645PLOS
February 2019

The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review

J Drugs Dermatol 2019 Feb;18(2):155-160

Introduction: Topical minoxidil is the first-line therapy for treating both male and female androgenetic alopecia. Currently there are no comprehensive reviews on the clinical efficacy of minoxidil on hair loss. Method: A literature search was conducted to identify clinically relevant studies regarding the efficacy of topical minoxidil for human subjects for hair loss. Read More

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February 2019

Platelet-Rich Plasma, a powerful tool in dermatology.

J Tissue Eng Regen Med 2019 Feb 22. Epub 2019 Feb 22.

Cellular and Functional Biology and Biomolecules Engineering Group. School of Science, Antonio Nariño University, Bogotá, Colombia.

Platelet-rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion-transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia and skin ulcers. Read More

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http://dx.doi.org/10.1002/term.2832DOI Listing
February 2019

Folliculotropic mycosis fungoides in a pediatric patient mimicking black dot tinea capitis.

Pediatr Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Section of Pediatric Dermatology, Departments of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

Immunosuppression following organ transplantation is a known risk factor for the development of lymphoproliferative disorders. Mycosis fungoides, a rare entity in pediatric patients, has seldom been reported as a post-transplant lymphoproliferative disorder. We report a case of folliculotropic mycosis fungoides in a pediatric patient following liver transplantation that was initially diagnosed as tinea capitis. Read More

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http://dx.doi.org/10.1111/pde.13768DOI Listing
February 2019

Epidermis Activated Gsdma3 Enhances Thermogenesis of Brown Adipose Tissue through Interleukin-6/Stat3 Signaling.

Am J Pathol 2019 Feb 18. Epub 2019 Feb 18.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, Model Animal Research Center, Nanjing University, Nanjing, China.

Missense mutations in the Gasdermin-A3 (Gsdma3) gene are associated with skin inflammation and hair loss in mice. However, the physiological function of Gsdma3 remains unclear. Here we reported that mice carrying the Gsdma3 Y344H mutation that encodes a presumptive activated form of Gsdma3, show increased heat production along with lower body fat percentages. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.012DOI Listing
February 2019

Differential expression patterns of specific long noncoding RNAs and competing endogenous RNA network in alopecia areata.

J Cell Biochem 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Long noncoding RNAs (lncRNAs) regulate gene expression by acting with microRNAs (miRNAs) and indirectly interact with messenger RNA (mRNAs). However, the roles of specific lncRNA and its related competing endogenous RNAs (ceRNA) network in alopecia areata (AA) are not fully understood.

Methods: The blood lncRNA profiles were obtained by microarray from 10 samples, including five alopecia areata samples and five normal samples. Read More

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http://dx.doi.org/10.1002/jcb.28365DOI Listing
February 2019

Phase II Trial of Eribulin in Patients With Metastatic Hormone Refractory Prostate Cancer: A Trial of the ECOG-ACRIN Cancer Research Group (E5805).

Am J Clin Oncol 2019 Feb 15. Epub 2019 Feb 15.

University of Kentucky, Lexington, KY.

Background: Eribulin mesylate, a synthetic analog of halichondrin B, is a novel tubulin-binding agent that inhibits cancer cell proliferation at low-nanomolar levels.

Methods: In a multicenter ECOG trial, patients with progressive metastatic CRPC, ECOG 0-2 were treated with eribulin 1.4 mg/m as an IV bolus over 5 minutes on days 1 and 8 of a 21-day cycle. Read More

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http://dx.doi.org/10.1097/COC.0000000000000526DOI Listing
February 2019

Curvilinear Alopecia in an Infant.

Clin Pediatr (Phila) 2019 Feb 21:9922819832033. Epub 2019 Feb 21.

1 University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1177/0009922819832033DOI Listing
February 2019

Alopecia and techniques in hair restoration: an overview for the cosmetic surgeon.

Oral Maxillofac Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Orthopedics and Plastic Surgery, Wright State University, Dayton, OH, USA.

Purpose: Alopecia is a debilitating disorder affecting millions of individuals worldwide. Although challenging to treat, advances in hair restoration technologies have led to multiple viable options with excellent clinical results. This paper seeks to provide an overview of hair loss and the currently utilized techniques in hair transplantation in order to serve as a reference source for the facial plastic surgeon. Read More

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http://dx.doi.org/10.1007/s10006-019-00750-9DOI Listing
February 2019

FEMALE PATTERN HAIR LOSS AND ANDROGEN EXCESS: A REPORT FROM THE MULTIDISCIPLINARY ANDROGEN EXCESS AND PCOS COMMITTEE.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology and Medicine, Duke University Medical Center, Durham, NC, USA.

Objective: To determine the current state of knowledge and provide evidence-based recommendations that could be valid for all specialists taking care of female pattern hair loss (FPHL), a common form of hair loss in women that is characterized by the reduction of hair density in the central area of the scalp, while the frontal hairline is generally well conserved.

Participants: An expert task force appointed by Androgen Excess and PPCOS society, which included specialists from dermatology, endocrinology, and reproductive endocrinology.

Evidence: Levels of evidence were assessed and graded from A to D. Read More

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http://dx.doi.org/10.1210/jc.2018-02548DOI Listing
February 2019
1 Read

Congenital Triangular Alopecia: A Brief Report.

Int J Trichology 2018 Nov-Dec;10(6):290-291

Department of Dermatology, The Third Hospital of Soochow University, Changzhou, Jiangsu 213003, China.

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http://dx.doi.org/10.4103/ijt.ijt_68_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369636PMC
February 2019

Suspected Herpes Zoster-associated Encephalitis during Treatment with Oral Tofacitinib in Alopecia Universalis.

Int J Trichology 2018 Nov-Dec;10(6):286-288

Department of Dermatology, University of California, Irvine, California, USA.

Systemic administration of Janus kinase inhibitors (JAKis) is associated with adverse events, including serious infections, malignancy, and herpes zoster (HZ). Herein, we report a case of a 17-year-old male with alopecia universalis who developed suspected HZ-associated encephalitis (HZAE) during treatment with oral tofacitinib. Oral tofacitinib was immediately discontinued, and the patient was started on antiviral treatment. Read More

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http://dx.doi.org/10.4103/ijt.ijt_87_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369645PMC
February 2019

New-Onset Androgenic Alopecia following Human Chorionic Gonadotropic Diet and Testosterone Pellet Implantation.

Int J Trichology 2018 Nov-Dec;10(6):284-285

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

A diet involving human chorionic gonadotropic (hCG) injections combined with extreme caloric restriction is sometimes undertaken by people desiring rapid weight loss. We report a patient with new-onset androgenic alopecia following hCG diet combined with the implantation of testosterone pellets. Read More

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http://dx.doi.org/10.4103/ijt.ijt_75_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369644PMC
February 2019

Nuchal Nevus Flammeus and Alopecia Areata: When Size Matters.

Int J Trichology 2018 Nov-Dec;10(6):275-277

Department of Dermatology, Hospital Clínic de Barcelona, Barcelona, Spain.

Introduction: Alopecia areata (AA) is a high-prevalence immuno-mediated hair loss disorder. Extra follicular affections, including nail and ocular abnormalities, are classically related to a worse prognosis of the disease, and previous studies have suggested that the presence of a persistent nuchal nevus flammeus (NNF) also indicates a greater severity and duration of the disease. The association between AA and persistent NNF was first described by Hatzis et al in 1988, who demonstrated that the relation was statistically evident and not due to a simple observer bias. Read More

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http://dx.doi.org/10.4103/ijt.ijt_82_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369638PMC
February 2019

The Impact of Alopecia Areata on Sexual Quality of Life.

Int J Trichology 2018 Nov-Dec;10(6):271-274

Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Alopecia areata (AA) is an autoimmune disease characterized by patches of hair loss that can cause decreased quality of life. This study evaluates the sexual quality of life for patients with AA.

Methods: We surveyed patients in the National Alopecia Areata Foundation patient registry using an online version of the validated Sexual Quality of Life for Females (SQOL-F) and Sexual Quality of Life for Males (SQOL-M) questionnaires. Read More

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http://dx.doi.org/10.4103/ijt.ijt_93_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369646PMC
February 2019

A Comment on the Science of Hair Aging.

Int J Trichology 2018 Nov-Dec;10(6):245-254

Department of Dermatology, Universidade Federal Fluminense, Centro de Ciencias Medicas, Hospital Universitario Antonia Pedro, Niterói-Rio de Janeiro, Brazil.

In contrast to the skin, aging of the hair has seemingly only recently found the attention of dermatological meetings, mainly promoted by the cosmetic industry for marketing purposes. In fact, basic scientists interested in the biology of hair growth and pigmentation have for some time already exposed the hair follicle as a highly accessible model with unique opportunities for the study of age-related effects. As a result, the science of hair aging focuses on two main streams of interest: the esthetic problem of aging hair and its management, in terms of age-related effects on hair color, quantity, and quality; and the biological problem of aging hair, in terms of microscopic, biochemical, and molecular changes underlying the aging process. Read More

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http://dx.doi.org/10.4103/ijt.ijt_56_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369639PMC
February 2019

A phase 1b/2, open-label, dose-escalation, and dose-confirmation study of eribulin mesilate in combination with capecitabine.

Br J Cancer 2019 Feb 20. Epub 2019 Feb 20.

Clinical Research Unit, Beatson West of Scotland Cancer Centre, Glasgow, UK.

Background: Capecitabine and eribulin are widely used as single agents in metastatic breast cancer (MBC) and have nonoverlapping toxicities.

Methods: In phase 1b (dose escalation), patients with advanced, treatment-refractory, solid tumours received eribulin mesilate intravenously in 21-day cycles according to schedule 1 (day 1) or schedule 2 (days 1, 8) with twice-daily oral capecitabine (1000 mg/m days 1-14). In phase 2 (dose confirmation), women with advanced/MBC and ≤3 prior chemotherapies received eribulin mesilate at the maximum tolerated dose (MTD) per the preferred schedule plus capecitabine. Read More

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http://dx.doi.org/10.1038/s41416-018-0366-5DOI Listing
February 2019

Outcomes and adverse effects associated with stereotactic body radiation therapy in dogs with nasal tumors: 28 cases (2011-2016).

J Am Vet Med Assoc 2019 Mar;254(5):602-612

OBJECTIVE To assess outcomes, factors associated with survival time, and radiation-induced toxicoses in dogs treated for nasal tumors with curative-intent stereotactic body radiation therapy (SBRT). DESIGN Retrospective case series. ANIMALS 28 client-owned dogs. Read More

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http://dx.doi.org/10.2460/javma.254.5.602DOI Listing

Evaluation of Association of Vitamin D in Alopecia Areata: A Case-control Study of 100 Patients in a Tertiary Rural Hospital of Southern India.

Indian Dermatol Online J 2019 Jan-Feb;10(1):45-49

Department of Dermatology, Raja Rajeswari Medical College and Hospital, Kambipura, Mysore Road, Bangalore, Karnataka, India.

Background: Alopecia areata is a common autoimmune disorder which is characterized by non-scarring hair loss. Vitamin D plays an important role in immune regulation, cell growth, differentiation, and maintenance of hair cycle.

Aims And Objectives: (1) To evaluate serum vitamin D levels in alopecia areata. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_84_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362755PMC
February 2019

Clinico-Epidemiological Profile of Patients with Vitiligo: A Retrospective Study from a Tertiary Care Center of North India.

Indian Dermatol Online J 2019 Jan-Feb;10(1):38-44

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.

Background: We studied clinico-epidemiological features of 945 patients with vitiligo with an objective to delineate epidemiological and clinical aspects of vitiligo from this part of the country.

Materials And Methods: The medical records of patients with vitiligo attending outpatient clinic over a 5-year period from January 2013 to December 2017 were analyzed retrospectively for this descriptive, observational study.

Results: There were 449 men and 496 women (m:f 1:1. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_124_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362747PMC
February 2019

Hyperadrenocorticism Caused by a Pituitary Ganglioglioma in a Dog.

Vet Pathol 2019 Feb 17:300985819829530. Epub 2019 Feb 17.

5 Laboratory of Veterinary Surgery, Department of Veterinary Clinical Medicine, Faculty of Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan.

An 11-year-old castrated male Chihuahua dog was presented with complaints of polyuria, polydipsia, abdominal enlargement, and alopecia. Hyperadrenocorticism was diagnosed on the basis of clinical signs, blood tests, adrenocorticotropin-stimulation test results, and an elevated serum adrenocorticotropin concentration. Contrast-enhanced magnetic resonance imaging showed that the pituitary gland was enlarged, compatible with a pituitary macroadenoma. Read More

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http://dx.doi.org/10.1177/0300985819829530DOI Listing
February 2019

A Summary of 2018 and What Lies Ahead for Dermatology and Therapy in 2019.

Dermatol Ther (Heidelb) 2019 Mar 15;9(1):1-3. Epub 2019 Feb 15.

Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester NIHR BRC, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s13555-019-0283-4DOI Listing
March 2019
1 Read

Citalopram-Associated Alopecia: A Case Report and Brief Literature Review.

Curr Drug Saf 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychiatry, Western Michigan University, Homer Stryker M.D. School of Medicine, Kalamazoo, MI . United States.

Background: Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatments for various psychiatric disorders. SSRIs offer improved side effect profile compared to older treatments, which improve patient adherence and quality of life.

Case Report: Here we discuss a case of an uncommon, but distressing side effect of citalopram. Read More

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http://dx.doi.org/10.2174/1574886314666190215115857DOI Listing
February 2019
2 Reads

Alopecia neoplastica as a sign of visceral malignancies: a systematic review.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio, Emilia, Italy.

Alopecia neoplastica (AN) from visceral tumors is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumor. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. Read More

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http://dx.doi.org/10.1111/jdv.15498DOI Listing
February 2019
1 Read

Estimating utilities/disutilities for high-risk metastatic hormone-sensitive prostate cancer (mHSPC) and treatment-related adverse events.

Qual Life Res 2019 Feb 14. Epub 2019 Feb 14.

Patient Centered Sciences, Mapi, Boston, USA.

Purpose: To capture UK societal health utility values for high-risk metastatic hormone-sensitive prostate cancer (mHSPC) and the disutility associated with treatment-related adverse events (AEs) to inform future cost-utility analyses.

Methods: A literature review, and patient and clinical expert interviews informed the development of health states characterising mHSPC symptoms and the impact of treatment-related AEs on health-related quality of life (HRQL). Three base health states were developed describing a typical patient with high-risk mHSPC: receiving androgen deprivation therapy (ADT) [Base State 1]; receiving docetaxel plus ADT [Base State 2]; completed docetaxel and still receiving ADT whose disease has not yet progressed [Base State 3]. Read More

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http://dx.doi.org/10.1007/s11136-019-02117-9DOI Listing
February 2019
1 Read

Genetic Susceptibility to Alopecia.

Authors:
Jouni Uitto

N Engl J Med 2019 Feb 13. Epub 2019 Feb 13.

From the Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Philadelphia.

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http://dx.doi.org/10.1056/NEJMe1900042DOI Listing
February 2019

Variant PADI3 in Central Centrifugal Cicatricial Alopecia.

N Engl J Med 2019 Feb 13. Epub 2019 Feb 13.

From the Department of Dermatology (L.M., O.S., A.P., M.P., E.W., L.S., V.B., J.M., E.S.) and the Institute of Pathology (A.G.), Tel Aviv Medical Center, the Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine (L.M., A.P., J.M., E.S.), and the Department of Cell and Developmental Biology (O.I., T.R., N.S.), Tel Aviv University, Tel Aviv, and the Schulich Faculty of Chemistry, Technion, Haifa (N.A.) - all in Israel; the Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany (M.-T.R., R.C.B.); L'Unité Différenciation Epitheliale et Autoimmunité Rhumatoïde (UDEAR), INSERM, Université Paul Sabatier, Université de Toulouse Midi-Pyrénées, Toulouse, France (M.-C.M., M.S.); the Department of Dermatology, Wake Forest Baptist Medical Center, Winston-Salem, NC (L.U., A.M.); and the Dermatology Department, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa (N.C.D).

Background: Central centrifugal cicatricial alopecia (CCCA) is the most common form of scarring alopecia among women of African ancestry. The disease is occasionally observed to affect women in families in a manner that suggests an autosomal dominant trait and usually manifests clinically after intense hair grooming. We sought to determine whether there exists a genetic basis of CCCA and, if so, what it is. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1816614
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http://dx.doi.org/10.1056/NEJMoa1816614DOI Listing
February 2019
4 Reads

JAK inhibitors for alopecia areata: a systematic review and meta-analysis.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Liverpool Hospital, Sydney, Australia.

Background: There have been a number of case reports and small clinical trials reporting promising outcomes of JAK inhibitors tofacitinib, ruxolitinib, and baracitinib for alopecia areata (AA). The majority of the literature to date is based on small volume data, with a lack of definitive evidence or guidelines.

Objective: To determine the expected response of AA to JAK inhibitor therapy, and factors which influence response and recurrence rates. Read More

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http://dx.doi.org/10.1111/jdv.15489DOI Listing
February 2019
1 Read

Ischemic modified albumin as a new biomarker in predicting oxidative stress in alopecia areata

Turk J Med Sci 2019 Feb 11;49(1):129-138. Epub 2019 Feb 11.

Background/aim: Results show that oxidative stress is a pathophysiologic factor for alopecia areata (AA); however, the markers used can be confounding. Thus, we aimed to investigate the role of oxidative stress in the pathogenesis of AA through an evaluation of ischemia-modified albumin (IMA); other markers of the oxidant/antioxidant system, such as SOD, CAT, GSH-ST, and MDA; and contributing clinical risk factors.

Materials And Methods: The usefulness of IMA as a new marker for oxidative stress was compared with that of other markers and evaluated in patients with AA. Read More

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http://dx.doi.org/10.3906/sag-1708-35DOI Listing
February 2019

Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice.

BMC Cancer 2019 Feb 13;19(1):149. Epub 2019 Feb 13.

Division of RI application, Korea Institute of Radiological and Medical Sciences, 75 Nowon-Gil, Gongneung-Dong, Nowon-Gu, Seoul, 01812, Korea.

Background: Chemotherapy-induced alopecia has been well documented as a cause of distress to patients undergoing cancer treatment. Almost all traditional chemotherapeutic agents cause severe alopecia. Despite advances in the treatment of chemotherapy-induced alopecia, there is no effective treatment for preventing chemotherapy-induced alopecia. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5323-zDOI Listing
February 2019
2 Reads

En coup de sabre.

Cutis 2019 Jan;103(1):34-36

St. Joseph Mercy Hospital System, Reichert Health Center, Ypsilanti, Michigan, USA.

En coup de sabre (ECDS) is a rare form of localized scleroderma that typically manifests in children and women. It presents as a fibrous pansclerotic plaque extending in a bandlike distribution on the frontoparietal scalp with surrounding scarring alopecia. Many patients have comorbid central nervous system involvement in addition to the cutaneous findings. Read More

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January 2019
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Trichoscopy features of trichotillomania.

Pediatr Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Dermatology, Hospital Clinico Universitario, Valencia, Spain.

Trichotillomania is a form of traction alopecia resulting from repetitive and compulsive hair pulling and plucking. Trichotillomania and patchy alopecia areata may have similar clinical and dermoscopic features in some cases. On trichoscopic examination, the presence of black dots, coiled or hook hair, shafts of varying lengths with fraying or split ends (trichoptilosis), and an absence of exclamation mark hairs and yellow dots are suggestive of trichotillomania. Read More

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http://dx.doi.org/10.1111/pde.13756DOI Listing
February 2019
2 Reads

The Effectiveness of Oral Mini-Pulse Methylprednisolonein - the Treatment of Alopecia Areata in Vietnam.

Open Access Maced J Med Sci 2019 Jan 29;7(2):291-292. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Background: Systemic corticosteroid is used to treat alopecia areata, but it is associated with side effects. Mini-pulse therapy is thought to be effective but able to reduce side effects.

Aim: The study aimed to evaluate the effectiveness of oral mini-pulse methylprednisolone in the treatment of alopecia areata. Read More

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http://dx.doi.org/10.3889/oamjms.2019.097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364712PMC
January 2019

Efficacy and Safety of Methotrexate in Combination with Mini Pulse Doses of Methylprednisolone in Severe Alopecia Areata. The Vietnamese Experience.

Open Access Maced J Med Sci 2019 Jan 23;7(2):200-203. Epub 2019 Jan 23.

University of Rome G. Marconi, Rome, Italy.

Background: Treatment of severe alopecia areata remains very difficult, especially in alopecia areata totalis and alopecia areata universalis. Methotrexate is known to be effective in the treatment of severe and chronic autoimmune disorders.

Objective: To assess the effectiveness and safety of MTX in combination with mini pulse dose of methylprednisolone in the treatment of severe alopecia areata. Read More

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http://dx.doi.org/10.3889/oamjms.2019.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364718PMC
January 2019

A Study of the Histopathological Features of Alopecias on Transverse Sections of Scalp Biopsies.

Indian J Dermatol 2019 Jan-Feb;64(1):47-54

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Transverse sections of scalp biopsies are performed for the assessment of alopecias and are considered advantageous over vertical sections.

Aim: The aim was to study the histopathological features of alopecias on transverse sections of scalp biopsies.

Methods: It was a descriptive study. Read More

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http://dx.doi.org/10.4103/ijd.IJD_477_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340243PMC
February 2019
2 Reads

The Association of Metabolic Syndrome and Insulin Resistance in Early-Onset Androgenetic Alopecia in Males: A Case-Control Study.

Indian J Dermatol 2019 Jan-Feb;64(1):23-27

Department of Dermatology, Venereology and Leprosy, Adichunchanagiri Institute of Medical Sciences, Mandya, Karnataka, India.

Background: Men with premature androgenetic alopecia (AGA) are found to be susceptible to cardiovascular diseases, metabolic syndrome (MS), diabetes mellitus and hypertension, and also premature baldness can have a definite negative impact on self-image and self-esteem in these patients. The aim of this study was to assess the strength of association between MS and/or insulin resistance (IR) in males with early-onset AGA.

Methods: A total of 50 male patients with premature AGA and equal number of age-matched controls were enrolled in the study. Read More

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http://dx.doi.org/10.4103/ijd.IJD_724_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340235PMC
February 2019
2 Reads

Clinical Profile of Androgenic Alopecia and Its Association with Cardiovascular Risk Factors.

Indian J Dermatol 2019 Jan-Feb;64(1):19-22

Department of Skin and VD, Amrita Institute of Medical Sciences, Kochi, Kerala, India.

Context: Androgenic alopecia (AGA) is a hereditary androgen-dependent disorder, characterized by gradual conversion of terminal hair into miniaturized hair and defined by various patterns. Common age group affected is between 30 and 50 years. Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that include diabetes and prediabetes, abdominal obesity, dyslipidemia, and hypertension. Read More

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http://dx.doi.org/10.4103/ijd.IJD_526_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340244PMC
February 2019
1 Read

Assessment of Metabolic Profile and Ischemia-modified Albumin Level in Patients with Alopecia Areata: A Case-Control Study.

Indian J Dermatol 2019 Jan-Feb;64(1):12-18

Department of Medical Biochemistry, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Background: Alopecia areata (AA) is an autoimmune-mediated hair follicle disorder. In the literature, there is no study evaluating metabolic syndrome and levels of ischemia-modified albumin (IMA) which is proposed as an oxidative stress biomarker in patients with AA.

Aims: The aim was to investigate the presence of metabolic syndrome and the levels of IMA, small dense low-density lipoprotein (sd-LDL), and visfatin levels in AA patients. Read More

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http://dx.doi.org/10.4103/ijd.IJD_238_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340238PMC
February 2019
2 Reads

Alopecia Areata Different View; Heavy Metals.

Indian J Dermatol 2019 Jan-Feb;64(1):7-11

Department of Dermatology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.

Background: Alopecia areata (AA) is a noncicatricial alopecia affecting any hair-bearing area. Although AA is considered to be an autoimmune disease, oxidative stress has been shown to be an important factor in the etiology of AA. Trace elements are highly essential for humans since they form the building blocks of large molecules, function as the cofactors of enzymes, and have some key biological functions. Read More

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http://dx.doi.org/10.4103/ijd.IJD_137_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340228PMC
February 2019
2 Reads

Pathogenesis of Alopecia Areata Based on Bioinformatics Analysis.

Indian J Dermatol 2019 Jan-Feb;64(1):1-6

Department of Toxicology, School of Public Health, Shaanxi University of Chinese Medicine, Xi'an, China.

Background: Alopecia areata (AA) describes a sudden localized patchy alopecia. The cause of AA is not completely clear and its incidence may be related to genetic, autoimmune, and environmental factors.

Aim: To explore the possible mechanisms of AA and to provide a basis for the early diagnosis and treatment of AA. Read More

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http://dx.doi.org/10.4103/ijd.IJD_68_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340232PMC
February 2019
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Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30859-3DOI Listing
February 2019
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Safety of eribulin as third-line chemotherapy in HER2-negative, advanced breast cancer pre-treated with taxanes and anthracycline: OnSITE study.

Breast J 2019 Feb 8. Epub 2019 Feb 8.

Medical Oncology Department, Hospital 12 De Octubre, Madrid, Spain.

Eribulin is active and safe in heavily pre-treated metastatic breast cancer patients. Few safety data have been published in third line. We aimed to report the specific safety profile on third line beyond taxanes and anthracyclines in advanced breast cancer (ABC). Read More

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http://dx.doi.org/10.1111/tbj.13199DOI Listing
February 2019
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LICHENOID FOLLICULITIS OF THE SCALP IN FOUR PATIENTS WITH ICHTHYOSIFORM SKIN DISORDERS AND CICATRICIAL ALOPECIA.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Dermatology, Federal Fluminense University, Antonio Pedro University Hospital, Marques de Parana Avenue, Niteroi, 24220-900, Brazil.

Ichthyosis is a heterogeneous group of inherited skin disorders characterized by a defect of keratinization. Patients diagnosed with lamellar ichthyosis (LI) and some ichthyosiform syndromes, such as the Conradi-Hünermann-Happle syndrome (CHHS), usually present with hair loss. Even though only few dermatologic complaints carry as many emotional overtones as hair loss, there is extremely little data available in the literature regarding scalp histopathologic features on ichthyosis. Read More

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http://dx.doi.org/10.1111/cup.13439DOI Listing
February 2019
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Polysaccharides as potential anticancer agents-A review of their progress.

Carbohydr Polym 2019 Apr 29;210:412-428. Epub 2019 Jan 29.

SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India.

Cancer is one of the most common diseases seen in developed countries, with over 1.6 million new cases estimated in 2017, in the US alone. The current chemotherapeutic drugs available for the therapeutic management of cancer are associated with major adverse effects like alopecia, anemia, immunodeficiency, fatigue, peripheral neuropathy, fertility issues and neurological problems, to name a few of them. Read More

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http://dx.doi.org/10.1016/j.carbpol.2019.01.064DOI Listing
April 2019
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Prostaglandins in androgenetic alopecia in 12 men and 4 female.

J Eur Acad Dermatol Venereol 2019 Feb 7. Epub 2019 Feb 7.

Universidad Autónoma de Nuevo León, Facultad de Medicina, Departamento de Dermatología, Monterrey, Mexico.

Androgenetic alopecia (AGA) is the most common form of hair loss in humans. Evidence suggests the participation of prostaglandins in the development of AGA. The aim of this study was to analyze the expression of the PTGDR2 (GPR44 receptor), PTGDS (Prostaglandin D2 synthase), and PTGES (Prostaglandin E synthase) transcripts in biopsies from balding scalp of hispanic patients with AGA and female androgenetic alopecia (FAGA). Read More

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http://dx.doi.org/10.1111/jdv.15479DOI Listing
February 2019
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[Androgen-secreting tumours of the ovaries].

Ugeskr Laeger 2019 Feb;181(6)

The diagnosis of an androgen-secreting tumour of the ovaries should be considered in women with hyperandrogenism. Clinical manifestations of hyperandrogenism include virilisation with hirsutism, vocal change, increased muscle mass, hypertrophy of clitoris and alopecia. Definitive diagnosis is made by histopathologic examination, and the most common diagnoses are granulosa cell tumour, ovarian stromal hyperplasia and Sertoli-Leydig cell tumour. Read More

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February 2019
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Autoimmune-Associated Hemophagocytosis and Myelofibrosis in a Newly Diagnosed Lupus Patient: Case Report and Literature Review.

Case Rep Hematol 2019 9;2019:3879148. Epub 2019 Jan 9.

Section of Hematology, Department of Medicine, UP-Philippine General Hospital, Manila, Philippines.

Bone marrow abnormalities in SLE are now becoming increasingly recognized, suggesting that the bone marrow may also be an important site of target organ damage. In this study, we present a rare case of concurrent autoimmune hemophagocytic syndrome and autoimmune myelofibrosis, potentially life-threatening conditions, in a newly diagnosed SLE patient. We report a case of a 30-year-old Filipino woman who presented with a one-year history of fever, constitutional symptoms, exertional dyspnea, joint pains, and alopecia and physical examination findings of fever, facial flushing, cervical lymphadenopathies, and knee joint effusions. Read More

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http://dx.doi.org/10.1155/2019/3879148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343163PMC
January 2019
1 Read