23,631 results match your criteria Androgenetic Alopecia

Clinical course of alopecia after severe acute respiratory syndrome coronavirus 2 infection.

Int J Infect Dis 2021 May 4. Epub 2021 May 4.

Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan; Emerging and Re-emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Japan.

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Alopecia areata is not a risk factor for heart diseases: A 10-year retrospective cohort study.

PLoS One 2021 7;16(5):e0250216. Epub 2021 May 7.

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

Alopecia areata (AA) is an autoimmune skin disease caused by chronic inflammation of hair follicles. Chronic inflammatory skin diseases such as psoriasis and lupus erythematosus can increase the risk of cardiovascular diseases. However, the relationship between AA and heart diseases (HDs) remains unclear. Read More

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Diffuse cicatricial alopecia and multiple telangiectatic indurated leg plaques.

Int J Dermatol 2021 Jun 9;60(6):e222-e226. Epub 2020 Aug 9.

Dermatology Department, Kasr Al Aini Hospital, Cairo University, Cairo, Egypt.

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Emerging Skin Toxicities in Patients with Breast Cancer Treated with New Cyclin-Dependent Kinase 4/6 Inhibitors: A Systematic Review.

Drug Saf 2021 May 6. Epub 2021 May 6.

Department of Dermatology, San Gallicano Dermatological Institute-IRCCS, Via Elio Chianesi 53, 00144, Rome, Italy.

Three cyclin-dependent kinases 4/6, including palbociclib, ribociclib, and abemaciclib, have been approved for the treatment of patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative advanced breast cancer. The objective of this study was to evaluate the occurrence and clinical spectrum of cutaneous adverse events in patients with breast cancer following therapy with cyclin-dependent kinase 4/6 inhibitors. A systematic literature search was performed in the PubMed, Cochrane, and EMBASE databases up to November 2020 to evaluate studies published from 2015 to 2020. Read More

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Case Report: Scarring Alopecia After Scalp Avulsion.

Mil Med 2021 May 7. Epub 2021 May 7.

Department of Dermatology, Naval Medical Center Portsmouth, Portsmouth, VA 23708, USA.

Scalp avulsion is a rare trauma in the developed world but is a common injury in countries with poorly established infrastructure and safety regulations. This case reports the long-term sequelae of this injury, observed while conducting a humanitarian mission, and discusses immediate actions for management in an acute setting. We aim to increase awareness about this injury, its risk factors, and treatment options to better prepare clinicians in the developed world to provide care for this condition in the austere environment, which may include not only chronic pain, functional, and aesthetic concerns, but also a psychological impact that persists years after the initial injury. Read More

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Nevus Unius Lateris with Bilateral Oral Mucosal Lesions: An Unusual Presentation.

Indian Dermatol Online J 2021 Mar-Apr;12(2):302-306. Epub 2021 Feb 22.

Department of Dermatology, Venereology and Leprosy, Government Medical College, Amritsar, Punjab, India.

Verrucous epidermal nevi (VEN) are cutaneous hamartomas characterized by keratinocytic hyperplasia. Majority are linear in distribution and tend to follow the Blaschko lines; however, some may have zosteriform (segmental) or systematized distribution involving widespread areas of skin. The systematized ones are further classified into "" when one-half of the body is affected, and "" showing bilateral distribution, both being the uncommon forms. Read More

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February 2021

Clinico-Epidemiological Profile of Childhood Alopecia Areata Along with Dermoscopic Correlation: A Cross-Section, Observational Study.

Indian Dermatol Online J 2021 Mar-Apr;12(2):250-257. Epub 2021 Mar 2.

Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.

Background: Childhood alopecia areata (AA) is a common cause of dermatologic consultation; however, data is scarce in the present set-up.

Objectives: To evaluate the clinico-epidemiological profile of childhood AA along with dermoscopic correlation.

Methods: We conducted a cross-sectional study including 50 new cases of childhood AA for 1 year. Read More

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Guided suturing technique for midface lift through minimal temporal incision.

J Plast Reconstr Aesthet Surg 2021 Apr 8. Epub 2021 Apr 8.

Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Science, 33 Badachu Rd., Shijingshan District, Beijing 100144, China. Electronic address:

Background: The midface has been a difficult zone to manage in rejuvenating surgeries. The major challenge for midface lift is to achieve extensive dissection and elevate the composite tissues en bloc through minimal incisions.

Methods: In a total of 22 composite midface lift cases, a titanium cable wire was used. Read More

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Permanent Alopecia in Breast Cancer Patients: Role of Taxanes and Endocrine Therapies.

Cutis 2021 Mar;107(3):E17-E22

Dr. Slaught is from the Department of Dermatology, Oregon Health and Science University, Portland. Dr. Roman is from the Department of Psychiatry, University of Pennsylvania, Philadelphia. Dr. Yashar is from the Dermatology Service, Veterans Affairs Greater Los Angeles Healthcare System, California. Drs. Holland and Goh are from the Department of Medicine, Division of Dermatology, UCLA Medical Center, Los Angeles.

Permanent chemotherapy-induced alopecia (PCIA) has been described following high-dose chemotherapy regimens for allogeneic bone marrow transplants; however, reports of PCIA in breast cancer patients are increasing. Many prior reports involve treatment with taxanes, but the role of endocrine therapies has not been well defined. Permanent alopecia in breast cancer patients appears to be a potential adverse effect of taxanes and endocrine therapies. Read More

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Reduction of telogen rate and increase of hair density in androgenetic alopecia by a cosmetic product: Results of a randomized, prospective, vehicle-controlled double-blind study in men.

J Cosmet Dermatol 2021 May 6. Epub 2021 May 6.

Department of Dermatology, Municipal Clinics Karlsruhe, Karlsruhe, Germany.

Background: Considerable parts of the global population are affected by androgenetic alopecia (AGA).

Aims: The efficacy of a foam containing nicotinic acid hexyl ester, polyphenols, zinc, glycine, and caffeine in comparison with a vehicle control foam was assessed in a double-blind vehicle-controlled study in men with AGA over 6 months.

Patients/methods: Sixty-two men with AGA were assigned either to the active ingredients (verum) or the vehicle group. Read More

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Aggregation of autoimmunity in extended families of people with autoimmune Addison's disease.

Intern Med J 2021 May 5. Epub 2021 May 5.

Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, 49 Przybyszewskiego, 60-355, Poznań, Poland.

Background: Autoimmunity accounts for 90% of cases of primary adrenal insufficiency (Addison's disease, AD). Affected persons present a significant co-occurrence of autoimmune conditions, hence, clustering of autoimmunity is also predicted among their relatives.

Aims: The aim of our study was to evaluate the burden of autoimmunity in families of people with AD. Read More

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Clinical report of a Holstein's calf with ichthyosis.

Vet Res Forum 2021 15;12(1):133-135. Epub 2021 Mar 15.

Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Congenital ichthyosis is a disease associated with hair loss and the presence of horny plates in the epidermis, covering the whole skin. The leading cause of the disease in humans and animals is genetic disorders, and they can be found in mild and severe forms. In June 2015, a newly born calf of the Holstein breed was referred to the Livestock Veterinary Hospital internal ward, Shabestar, Iran. Read More

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Wal Mutant Mice Have a Mutation Associated with Autism Spectrum Disorders.

Dokl Biol Sci 2021 Mar 4;497(1):59-61. Epub 2021 May 4.

Koltsov Institute of Developmental Biology, Russian Academy of Sciences, 119334, Moscow, Russia.

The waved alopecia (wal) mutation arose spontaneously in mice. Phenotypically, the wal mutation in a homozygous recessive state is manifested by a wavy coat. Over time, partial baldness develops, which leads to a thinning of the coat in mice. Read More

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Evolving Phenotypes of non-hospitalized Patients that Indicate Long Covid.

medRxiv 2021 Apr 27. Epub 2021 Apr 27.

Many of the symptoms characterized as the post-acute sequelae of SARS-CoV-2 infection (PASC) could have multiple causes or similarly seen in non-COVID patients. An accurate identification of phenotypes will be important to guide future research and the healthcare system to focus its efforts and resources on adequately controlled age- and gender-specific sequelae of COVID-19 infection. This retrospective electronic health records (EHR) cohort study, we applied a computational framework for knowledge discovery from clinical data, MLHO, to identify phenotypes that positively associate with a past positive PCR test for COVID-19. Read More

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Comedonal plaque on the scalp.

JAAD Case Rep 2021 May 25;11:90-92. Epub 2021 Mar 25.

Department of Dermatology, Mohammed V University in Rabat, Ibn Sina University Hospital, Rabat, Morocco.

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The Naming of Alopecia Areata.

Ann Med Hist 1931 Sep;3(5):540-546

San Francisco.

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September 1931

A Phase 1 Study to Investigate the Effects of Cortexolone 17α-Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity.

Clin Pharmacol Drug Dev 2021 May 3. Epub 2021 May 3.

St George's, University of London, London, United Kingdom.

Cortexolone 17α-propionate, also known as clascoterone, is a potent androgen receptor inhibitor intended for the topical treatment of skin diseases associated with androgenic pathway alterations. In nonclinical studies, cortexolone 17α-propionate was found to have a weak inhibitory effect on human Ether-à-go-go-Related Gene (hERG) potassium channels, which are vital for normal electrical activity in the heart. When used in a cream formulation, little cortexolone 17α-propionate is absorbed. Read More

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Biallelic splicing variants in the nucleolar 60S assembly factor RBM28 cause the ribosomopathy ANE syndrome.

Proc Natl Acad Sci U S A 2021 May;118(19)

Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT 06520;

Alopecia, neurologic defects, and endocrinopathy (ANE) syndrome is a rare ribosomopathy known to be caused by a p.(Leu351Pro) variant in the essential, conserved, nucleolar large ribosomal subunit (60S) assembly factor RBM28. We report the second family of ANE syndrome to date and a female pediatric ANE syndrome patient. Read More

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Treatment of Pediatric Alopecia Areata: A Systematic Review.

J Am Acad Dermatol 2021 Apr 30. Epub 2021 Apr 30.

Department of Dermatology, University of California Davis, Sacramento, CA, USA; Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA, USA. Electronic address:

Background: Alopecia areata (AA) is an autoimmune, non-scarring hair loss disorder with slightly greater prevalence in children than adults. Various treatment modalities exist; however, their evidence in pediatric AA patients is lacking.

Methods: We conducted a systematic review on the PubMed database in October 2019 for all published articles involving patients <18 years old. Read More

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Home-based devices in dermatology: a systematic review of safety and efficacy.

Arch Dermatol Res 2021 May 3. Epub 2021 May 3.

Department of Dermatology, State University of New York, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY, 11203, USA.

There is increasing demand for home-based devices for the treatment of dermatologic conditions and cosmesis. Commercially available devices include intense pulsed light, laser diodes, radiofrequency, light-emitting diodes, and ultraviolet B phototherapy. The objective of this report is to evaluate the current evidence regarding the efficacy and safety of home-based devices for the treatment of skin conditions. Read More

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Camouflaging techniques for patients with central centrifugal cicatricial alopecia.

Int J Womens Dermatol 2021 Mar 27;7(2):180-183. Epub 2020 Nov 27.

University of Mississippi Medical Center, Jackson, MS, United States.

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The art of prevention: It's too tight-Loosen up and let your hair down.

Int J Womens Dermatol 2021 Mar 29;7(2):174-179. Epub 2021 Jan 29.

Department of Dermatology, Howard University College of Medicine, Washington, District of Columbia, United States.

Traction alopecia is prevalent in patients of color. Its significance in clinical practice may be underemphasized due to the transient nature of the condition; however, it has the potential to become permanent and cause significant psychosocial distress. Understanding of afro-textured hair and cultural practices, as well as early recognition and treatment, provides an opportunity to prevent permanent traction alopecia and long-term sequelae. Read More

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A boy with multiple patches of alopecia and an affected cat.

Paediatr Child Health 2021 Jun 9;26(3):135-136. Epub 2020 Apr 9.

Department of Pediatrics, The University of Calgary, Alberta Children's Hospital, Calgary, Alberta.

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Case Report: Reversal of Long-Standing Refractory Diffuse Non-Scarring Alopecia Due to Systemic Lupus Erythematosus Following Treatment With Tofacitinib.

Front Immunol 2021 14;12:654376. Epub 2021 Apr 14.

Department of Rheumatology and Immunology, Shenzhen People's Hospital (The First Affiliated Hospital of Southern University of Science and Technology), The Second Clinical Medical College of Jinan University, Shenzhen, China.

The Janus kinases (JAKs) are intracellular tyrosine kinases involved in a broad variety of inflammatory cascades participating in the pathogenesis of systemic lupus erythematosus (SLE). Diffuse non-scarring alopecia is one of the most frequent cutaneous manifestations in SLE, resulting in devastating psychosocial consequences. Although recent studies have shown promising outcomes of the JAK inhibitors in SLE treatment, the efficacy of tofacitinib in diffuse non-scarring alopecia due to SLE has never been reported. Read More

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Male frontal fibrosing alopecia: study of 35 cases and association with sunscreens, facial skin and hair care products.

J Eur Acad Dermatol Venereol 2021 May 1. Epub 2021 May 1.

Center for Dermatology and Hair Diseases Professor Trüeb, Zürich-Wallisellen, Switzerland.

Frontal fibrosing alopecia (FFA) represents a peculiar progressive marginal scarring alopecia. Initially considered uncommon, its frequency has increased exponentially, while its etiology has remained obscure, attracting the attention of the medical community and giving rise to speculations on the role of environmental factors. Questionnaire-based studies have suggested an association between FFA and the use of facial moisturizers and sunscreens. Read More

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Teprotumumab: interpreting the clinical trials in the context of thyroid eye disease pathogenesis and current therapies.

Ophthalmology 2021 Apr 27. Epub 2021 Apr 27.

Department of Ophthalmology, University of California, San Francisco, 490 Illinois Street, San Francisco, CA 94143.

Teprotumumab, a monoclonal antibody targeted against the insulin-like growth factor-1 (IGF-1) receptor, was recently approved by the United States Food and Drug Administration (FDA) for the treatment of thyroid eye disease (TED). Phase I studies of teprotumumab for the treatment of malignancies demonstrated an acceptable safety profile but limited effectivity. Basic research implicating the IGF-1 receptor on the CD-34+ orbital fibrocyte in the pathogenesis of TED renewed interest in the drug. Read More

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Xanthine oxidase activity in thiopurine curative Chinese inflammatory bowel disease patients.

Pharmacol Res Perspect 2021 May;9(3):e00764

Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China.

Xanthine oxidase (XO) competes with thiopurine S-methyltransferase (TPMT) and hypoxanthine guanine phosphoribosyltransferase (HPRT) to metabolize azathioprine (AZA)/6-mercaptopurine (6-MP) in vivo. A retrospective investigation was performed to detect the activity of XO in thiopurine curative Chinese inflammatory bowel disease (IBD) patients. We also evaluated whether a relationship between XO activity and incidence of thiopurine-induced adverse effects (AEs) existed. Read More

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