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    19618 results match your criteria Androgenetic Alopecia

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    Ruxolitinib-conjugated gold nanoparticles for topical administration: An alternative for treating alopecia?
    Med Hypotheses 2017 Nov 27;109:42-45. Epub 2017 Sep 27.
    Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.
    Alopecia is a dermatological condition for which Janus kinase (JAK) inhibitors have recently emerged as potential therapy options, but with limited practical use because of the systemic side effects. The topical use of Ruxolitinib in alopecia universalis has been demonstrated, but little is known about the pharmacodynamics and pharmacokinetics of this way of administration. Nanomedicine provides improved therapeutics. Read More

    GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.
    Nat Commun 2017 Nov 17;8(1):1584. Epub 2017 Nov 17.
    Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
    Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; however, the known genes explain little of the heritability. Here, we present the results of a genome-wide association study including more than 70,000 men, identifying 71 independently replicated loci, of which 30 are novel. These loci explain 38% of the risk, suggesting that MPB is less genetically complex than other complex traits. Read More

    [NISCH syndrome, a rare cause of neonatal cholestasis: A case report].
    Arch Pediatr 2017 Nov 13. Epub 2017 Nov 13.
    Service de gastropédiatrie, Assistance publique-Hôpitaux de Marseille (AP-HM), hôpital de La Timone, 264, rue Saint-Pierre, 13385 Marseille, France.
    NISCH syndrome is a rare autosomal recessive disease. It is characterized by scalp hypotrichosis, scarring alopecia, ichthyosis, and neonatal sclerosing cholangitis. It is caused by mutations in the CLDN1 gene encoding the claudin-1 protein, which is located at tight junctions. Read More

    New Insight Into the Pathophysiology of Hair Loss Trigger a Paradigm Shift in the Treatment Approach.
    J Drugs Dermatol 2017 Nov;16(11):s135-s140

    Hair loss affects millions of men and women of all ages and ethnicities, impacting appearance, social interactions, and psycho-emotional well-being. Although a number of options are available, they are limited, carry a potential risk of side effects, and none have proven to be comprehensive for treatment of hair loss. Across the spectrum of hair loss disorders, there has long been a segmentation into distinct mechanisms, driving the main trend in current therapeutics to focus on targeting single molecules or pathways. Read More


    Vitamin D Deficiency in an Alopecia Referral Clinic During a 3-Month Period: The Need to Pursue Systemic Screening.
    Skinmed 2017 1;15(5):339-341. Epub 2017 Oct 1.
    Dermatology Department, Kaiser Permanente Health Network, Vallejo, CA.
    Alopecia is typically viewed as a localized process, and comorbidities are not usually analyzed. The authors examine the prevalence of vitamin D deficiency among patients attending an alopecia clinic during a 3-month period. The data showed that 79% of patients had vitamin D deficiency, and the average value of low vitamin D was 19. Read More

    Early-onset baldness and the risk of aggressive prostate cancer: findings from a case-control study.
    Cancer Causes Control 2017 Nov 14. Epub 2017 Nov 14.
    Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
    Purpose: We aimed to evaluate the associations between androgenetic alopecia at a young age and subsequent development of aggressive prostate cancer (PC).

    Methods: Using a case-control design with self-administered questionnaire, we evaluated the association between aggressive PC and very early-onset balding at age 20, and early-onset balding at age 40 years in 1,941 men. Cases were men with high-grade and/or advanced stage cancer and controls were clinic based men who had undergone biopsy and were found to be histologically cancer negative. Read More

    Recessive Mutation in Tetraspanin CD151 Causes Kindler Syndrome-like Epidermolysis Bullosa with Multi-systemic Manifestations Including Nephropathy.
    Matrix Biol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA; Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:
    Epidermolysis bullosa (EB) is caused by mutations in as many as 19 distinct genes. We have developed a next-generation sequencing (NGS) panel targeting genes known to be mutated in skin fragility disorders, including tetraspanen CD151 expressed in keratinocytes at the dermal-epidermal junction. The NGS panel was applied to a cohort of 92 consanguineous families of unknown subtype of EB. Read More

    Unilesional Follicular Mycosis Fungoides: Report of 6 Cases and Review of the Literature.
    Am J Dermatopathol 2017 Oct 24. Epub 2017 Oct 24.
    *Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY; †Division of Dermatology, Memorial Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, RI; and ‡Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
    Unilesional follicular mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma characterized by selective involvement of the hair follicles by neoplastic T lymphocytes presenting initially as a solitary lesion occupying less than 5% of the body surface; there are 22 previous reported cases. We describe 6 patients with this rare variant of MF, all males (age range 6-64 years; mean age: 28 years) presenting with a solitary lesion primarily on the face and scalp except 1 patient who presented with a truncal lesion. All the patients had the lesions for at least a few months. Read More

    Skin Manifestations of Targeted Antineoplastic Therapy.
    Curr Probl Dermatol 2018 7;53:93-104. Epub 2017 Nov 7.
    Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain.
    The management of oncology patients has changed significantly over recent years, with the development of new targeted anticancer therapies. Cutaneous adverse effects are among the most frequently observed toxicities with many targeted agents; their intensity can be dose-limiting or lead to the discontinuation of therapy. Tyrosine kinase inhibitors can cause maculopapular rash and hand-foot reaction, whereas papulopustular rash, paronychia, regulatory changes in hair, and dryness are caused by epidermal growth factor receptor inhibitors. Read More

    Efficacy of subcutaneous injection of platelet-rich plasma in alopecia: A clinical and histological pilot study on a rat model with a six-month long-term follow-up experience.
    J Cosmet Dermatol 2017 Nov 11. Epub 2017 Nov 11.
    Université Paris Diderot, Paris, France.
    Purpose: To assess the potential of platelet-rich plasma (PRP) subcutaneous injection of to treat alopecia and to evaluate local toxicity.

    Materials-methods: Twelve Hairless rats were used. At D0, we performed systematic clinical examination and divided the rat back into four quadrants (Q). Read More

    Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid.
    Stem Cells Int 2017 10;2017:9271869. Epub 2017 Oct 10.
    Laboratory of Cell Biology, N.K. Koltzov Institute of Developmental Biology, 26 Vavilov St., Moscow 119334, Russia.
    Hair follicle (HF) reconstruction in vitro is a promising field in alopecia treatment and human HF development research. Here, we combined postnatal human dermal papilla (DP) cells and skin epidermal keratinocytes (KCs) in a hanging drop culture to develop an artificial HF germ. The method is based on DP cell hair-inducing properties and KC self-organization. Read More

    Objective Outcome Measures: Collecting Meaningful Data on Alopecia Areata.
    J Am Acad Dermatol 2017 Nov 8. Epub 2017 Nov 8.
    University of Minnesota, Minneapolis, MN.
    Background: Although alopecia areata is a common disorder, it has no FDA approved treatment and evidence-based therapeutic data is lacking.

    Objective: To develop guidelines for the diagnosis, evaluation, assessment, response criteria and endpoints for alopecia areata.

    Methods: Literature review and expert opinion of a group of dermatologists specializing in hair disorders. Read More

    Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with Alopecia.
    Sci Rep 2017 Nov 10;7(1):15337. Epub 2017 Nov 10.
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
    The functional study of different mutations on vitamin D receptor (VDR) gene causing hereditary vitamin D-resistant rickets (HVDRR) remains limited. This study was to determine the VDR mutation and the mechanisms of this mutation-causing phenotype in a family with HVDRR and alopecia. Phenotype was analyzed, and in vitro functional studies were performed. Read More

    Effects of management practices on the welfare of dairy donkeys and risk factors associated with signs of hoof neglect.
    J Dairy Res 2017 Nov 10:1-9. Epub 2017 Nov 10.
    Dipartimento di Medicina Veterinaria,Università degli Studi di Milano,20133 Milano,Italy.
    This Research Paper aimed to investigate donkey welfare in dairy husbandry systems and to identify the potential factors affecting it at animal level. In 2015, twelve dairy donkey farms (19-170 donkeys per farm, mean = 55 ± 48), distributed throughout Italy, were visited. On each farm, the Animal Welfare Indicators (AWIN) welfare assessment protocol for donkeys was used by two trained assessors to evaluate the welfare of animals for a total of 257 donkeys assessed. Read More

    Identification of functional patterns of androgenetic alopecia using transcriptome profiling in distinct locations of hair follicles.
    J Invest Dermatol 2017 Nov 6. Epub 2017 Nov 6.
    Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province, 510515, China. Electronic address:

    The technique of superselective ophthalmic artery chemotherapy for retinoblastoma: The Garrahan Hospital experience.
    Interv Neuroradiol 2017 Jan 1:1591019917738962. Epub 2017 Jan 1.
    3 Department of Oncology, 36947 Hospital Nacional de Pediatria JP Garrahan , Buenos Aires, Argentina.
    Background Superselective ophthalmic artery chemotherapy (SOAC) is a proven therapy for the treatment of retinoblastomas. We describe the technique, results and complications of SOAC performed in our hospital. Objective The aim of this article is to demonstrate that a seemingly complex technique can be carried out with a low morbidity rate. Read More

    Three Cases of Hair Loss Analyzed by the Point of View of the Analytical Psychology.
    Int J Trichology 2017 Oct-Dec;9(4):177-180
    Department of Clinical Psychology, Pontifícia universidade Católica de São Paulo, São Paulo, Brazil.
    Psychotrichology is the science, which covers the psychosomatics applied to hair problems, i.e., body-psyche phenomena involving scalp and hair disorders. Read More

    A Proposal of an Effective Platelet-rich Plasma Protocol for the Treatment of Androgenetic Alopecia.
    Int J Trichology 2017 Oct-Dec;9(4):165-170
    Department of Dermatology, Hospital Clínic, University of Barcelona, Barcelona, Spain.
    Background: Platelet-rich plasma (PRP) has emerged as a promising treatment for androgenetic alopecia (AGA). In spite of the several studies previously reported, to date, a standardized protocol for PRP preparation and application, as well as a standard method for evaluating results has not been established.

    Aims: The aim of this study is to propose a standardized method for preparation and application of PRP for male AGA (MAGA) and female AGA (FAGA) and assess its safety and efficacy as a co-adjuvant therapy. Read More

    Utilization of Mental Health Resources and Complementary and Alternative Therapies for Alopecia Areata: A U.S. Survey.
    Int J Trichology 2017 Oct-Dec;9(4):160-164
    Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.
    Background: The efficacy of traditional medical treatments for alopecia areata (AA) is limited, leading some to pursue alternative treatments. The utilization and nature of these treatments are unclear.

    Objective: To assess the extent to which patients with AA pursue alternative treatments and to characterize these treatments. Read More

    Detection of Tumor Necrosis Factor-alpha in Nonlesional Tissues of Alopecia Areata Patients: A Prove for a Systemic Disease.
    Int J Trichology 2017 Oct-Dec;9(4):154-159
    Department of Biochemistry, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt.
    Introduction: The pathogenesis of alopecia areata (AA) remains incompletely understood. Different cytokines may play a role in AA. Tumor necrosis factor-alpha (TNF-α) has been shown to be inhibitory to hair follicle growth in in vitro studies suggesting that it may play an important role in AA. Read More

    Insignificant Correlation between Thyroid Hormone and Antithyroid Peroxidase Antibodies in Alopecia Areata Patients in Northern Rajasthan.
    Int J Trichology 2017 Oct-Dec;9(4):149-153
    Department of Dermatology, STDs and Leprosy, SMS Medical College, Jaipur, Rajasthan, India.
    Background: Alopecia areata (AA) is a common, recurrent form of nonscarring alopecia which often presents as circumscribed patches of spontaneous hair loss. The global prevalence of this disease varies from 0.1% to 0. Read More

    Dissecting Cellulitis of the Scalp Early Diagnosed by Color Doppler Ultrasound.
    Int J Trichology 2017 Oct-Dec;9(4):147-148
    Department of Dermatology, Faculty of Medicine, Pontifical Catholic University, Santiago, Chile.
    Dissecting cellulitis of the scalp (DC) is a chronic inflammatory condition of the scalp that ultimately leads to scarring alopecia. A healthy 19-year-old male presented with a solitary, soft, alopecic nodule that had appeared 1 year before. A color Doppler ultrasound examination showed a hypodermal anechoic fluid collection in the left parietotemporal region of the scalp, connected to the base of widened hair follicles, and presented inner echoes suggestive of debris, as well as several fragments of hair tracts. Read More

    Monogenic interferonopathies: Phenotypic and genotypic findings of CANDLE syndrome and its overlap with C1q deficient SLE.
    Int J Rheum Dis 2017 Nov 8. Epub 2017 Nov 8.
    Department of Allergy and Immunology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
    Objective: To report the clinical and genetic features of the first cases of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome in an Arab population and to compare them with patients of C1q deficient systemic lupus erythematosus (SLE).

    Materials And Methods: This is a retrospective case series of patients with CANDLE syndrome and C1q deficient SLE seen at a single tertiary hospital. Medical records were reviewed for demographic data, clinical and laboratory features, histopathology and imaging findings, and response to therapeutic intervention. Read More

    Subclinical Sensitization with Diphenylcyclopropenone is Sufficient for the Treatment of Alopecia Areata: Retrospective Analysis of 159 Cases.
    J Am Acad Dermatol 2017 Nov 3. Epub 2017 Nov 3.
    Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. Electronic address:
    Background: Contact immunotherapy with diphenylcyclopropenone (DPCP) is presently considered the treatment of choice for extensive alopecia areata (AA). However, a major concern with contact immunotherapy is that it causes various adverse effects (AEs) that contribute to discontinuation of treatment.

    Objective: We investigated whether a modified DPCP treatment protocol can promote hair regrowth with fewer AEs. Read More

    Epithelial-mesenchymal stem cell transition in a human organ: Lessons from lichen planopilaris.
    J Invest Dermatol 2017 Oct 26. Epub 2017 Oct 26.
    Centre for Dermatology Research, University of Manchester, MAHSC and NIHR Biomedical Research Centre, Manchester, UK. Electronic address:
    Epithelial-to-mesenchymal transition (EMT) is critical for embryonic development and wound healing, and occurs in fibrotic disease and carcinoma. Here, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of human scalp hair follicles (HFs), during the inflammatory permanent alopecia, lichen planopilaris (LPP). We show that a molecular EMT signature can be experimentally induced in healthy human eSCs in situ by antagonizing E-cadherin, combined with TGF-ß1, EGF, and interferon-γ administration, which to our knowledge is previously unreported. Read More

    Pediatric severity of alopecia tool.
    Pediatr Dermatol 2017 Nov 6. Epub 2017 Nov 6.
    Division of Pediatrics, Section of Dermatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    The Severity of Alopecia Tool serves as a tool for alopecia research and a clinical guideline for following progression of disease. The original Severity of Alopecia Tool score does not take into account pediatric age groups. As new clinical trials for alopecia areata include more children, a more accurate tool should be available for this population. Read More

    An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata.
    J Invest Dermatol 2017 Nov 3. Epub 2017 Nov 3.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. Electronic address:
    Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Read More

    Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma (PRP) for Treating Androgenic Alopecia.
    Aesthetic Plast Surg 2017 Nov 3. Epub 2017 Nov 3.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Meram Faculty of Medicine, Necmettin Erbakan University, 42080, Meram, Konya, Turkey.
    Background: Androgenetic alopecia (AGA), the most common cause of hair loss in both sexes, accounts for 95% of all cases of hair loss. Although the literature has suggested that both nonactivated (n-PRP) and activated autologous (a-PRP) PRP can be used to treat AGA, we did not find any study investigating the use of homologous PRP (h-PRP) for this purpose. Also, to the best of our knowledge, there are no studies comparing the efficacy of h-PRP, a-PRP, or n-PRP on AGA therapy. Read More

    Social hair pulling in captive rhesus macaques (Macaca mulatta).
    Am J Primatol 2017 Nov 2. Epub 2017 Nov 2.
    Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon.
    Alopecia is common among captive populations of nonhuman primates. There are many potential causes of alopecia, including physiological conditions such as hormonal imbalance and infection, features of the captive environment such as housing type, ground substrate, and group density, as well as behavioral abnormalities such as self-plucking. A potential behavioral cause of alopecia in group-housed primates is social hair pulling, where one animal pulls hair from a conspecific. Read More

    Hematuria and Hematospermia Associated with the Use of Finasteride for the Treatment of Androgenic Alopecia: A Case Report.
    Drug Saf Case Rep 2017 Oct 31;4(1):14. Epub 2017 Oct 31.
    New Mansoura General Hospital, Mansoura, Egypt.
    In this report we address an unusual adverse effect of finasteride (Propecia 1 mg tablets) that was associated with painless hematuria and hematospermia in a 38-year-old healthy male during treatment of androgenic alopecia at a dose of 1 mg/day. It was found that the bleeding was linked to finasteride use as it occurred 2-3 days after use and stopped upon discontinuation of the drug. The patient was subjected to urological examination, laboratory investigations, and radiological imaging to identify the probable cause of bleeding. Read More

    Development and evaluation of finasteride loaded ethosomes for targeting to the pilosebaceous unit.
    Artif Cells Nanomed Biotechnol 2017 Oct 31:1-10. Epub 2017 Oct 31.
    a Department of Pharmaceutics , PSG College of Pharmacy , Coimbatore , India.
    Androgenetic alopecia, a major cause for baldness, is caused by the deposition of dihydrotestosterone (DHT) at the androgen receptors present in the pilosebaceous unit (PSU). Finasteride (FIN) is a potent 5α-reductase inhibitor capable of preventing the conversion of testosterone to DHT. But, its oral administration in males causes infertility. Read More

    Alopecia Areata. Current situation and perspectives.
    Arch Argent Pediatr 2017 Dec;115(6):e404-e411
    Centro Dermatológico Brunnenhalt de Reynosa, Reynosa, Tamaulipas, México.
    Alopecia areata (AA) is a dermatological disease characterized by non-scarring hair loss of the scalp and/or body, with an unpredictable and variable evolution in the patients in which, despite multidisciplinary efforts, its etiology is not entirely known, although some evidence suggests that environmental, immunological and genetic factors could be generating the disease. The aim of this review is to provide an updated panorama of the clinical characteristics, diagnosis and treatment of AA, to analyze the mechanisms that could participate in its etiology, as well as to review some of the most important genetic variants that could confer susceptibility to the development of this disease. Read More

    Syphilitic alopecia: uncommon trichoscopic findings.
    Dermatol Pract Concept 2017 Jul 31;7(3):55-59. Epub 2017 Jul 31.
    Dermatology Unit, Department of Medical, Surgical and Neuro Sciences, University of Siena, Siena, Italy.
    Syphilitic alopecia (SA) is considered an uncommon manifestation of secondary syphilis. SA can present in a diffuse form, resembling telogen effluvium, or in a moth-eaten form that mimics a variety of conditions (i.e. Read More

    Alopecia areata is characterized by expansion of circulating Th2/Tc2/Th22, within the skin-homing and systemic T-cell populations.
    Allergy 2017 Oct 30. Epub 2017 Oct 30.
    Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Background: Characterizing blood profile of alopecia areata (AA) is not only important for treatment advancements, but also for possibly identifying peripheral biomarkers that will eliminate the need for scalp biopsies. We aimed to compare frequencies of skin homing (CLA(+) ) vs. systemic (CLA(-) ) "polar" CD4(+) and CD8(+) and activated T-cell subsets in AA vs. Read More

    Genome-wide microRNA analysis implicates miR-30b/d in the etiology of alopecia areata.
    J Invest Dermatol 2017 Oct 25. Epub 2017 Oct 25.
    Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. Electronic address:
    Alopecia areata (AA) is one of the most common forms of human hair loss. Although genetic studies have implicated autoimmune processes in AA etiology, understanding of the etiopathogenesis is incomplete. Recent research has implicated microRNAs, a class of small non-coding RNAs, in diverse autoimmune diseases. Read More

    Characterization of minoxidil/hydroxypropyl-β-cyclodextrin inclusion complex in aqueous alginate gel useful for alopecia management: Efficacy evaluation in male rat.
    Eur J Pharm Biopharm 2017 Oct 24. Epub 2017 Oct 24.
    Pharmaceutical Technology, Department of Pharmacy- Pharmaceutical Sciences, University of Bari, Italia.
    Solid inclusion complex between hydroxypropyl-β-cyclodextrin (HP-β-CD) and minoxidil (MXD) was prepared by freeze-drying and characterized by yield, drug loading and dissolution rate. Moreover, the complex was formulated as alginate gel (GEL HP-β-CD)/MXD 3.5% w/w). Read More

    The effect of plasma rich in growth factors combined with follicular unit extraction surgery for the treatment of hair loss: A pilot study.
    J Cosmet Dermatol 2017 Oct 26. Epub 2017 Oct 26.
    BTI Biotechnology Institute, Vitoria (Álava), Spain.
    Background: Hair transplant surgery using follicular unit extraction technique (FUE) is a common surgical procedure for the treatment of severe hair loss. Blood-derived autologous growth factors have also proved to promote hair regeneration in patients with different types of alopecia.

    Aims: The aim of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGF) technology as an adjuvant therapy for FUE surgery in hair loss affected patients. Read More

    Lichen planus pigmentosus and its variants: review and update.
    Int J Dermatol 2017 Oct 26. Epub 2017 Oct 26.
    Department of Dermatology, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Nuevo León, México.
    Lichen planus pigmentosus (LPP) is considered a rare variant of lichen planus (LP). It is characterized by acquired dark brown to gray macular pigmentation located on sun-exposed areas of the face, neck, and flexures, commonly found in dark-skinned patients. In patients with LPP, an inflammatory lichenoid response results in marked pigmentary incontinence. Read More

    Dramatic effect of hydroxychloroquine on lupus alopecia.
    J Dermatol 2017 Oct 25. Epub 2017 Oct 25.
    Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
    Lupus alopecia is usually difficult to treat. We report a case of a 40-year-old woman with Sjögren's syndrome and atopic dermatitis who presented with discoid lupus erythematosus on the forearms and lupus erythematosus profundus with alopecia involving the scalp. A biopsy specimen taken from the discoid lupus erythematosus lesion on the forearm further exhibited a xanthomatous reaction, which however was not detected in another specimen from the lupus erythematosus profundus on the scalp. Read More

    Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X.
    PLoS One 2017 24;12(10):e0186469. Epub 2017 Oct 24.
    Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
    Alopecia X is a hair cycle arrest disorder in Pomeranians. Histologically, kenogen and telogen hair follicles predominate, whereas anagen follicles are sparse. The induction of anagen relies on the activation of hair follicle stem cells and their subsequent proliferation and differentiation. Read More

    Hair Transplantation Controversies.
    Dermatol Surg 2017 Nov;43 Suppl 2:S158-S162
    *Private Practice, Dermatology, New York, New York; †Weill Cornell Medical Center, New York, New York; ‡Heights Dermatology, Brooklyn, New York; §Tulane Health Sciences Center, New Orleans, Louisiana; ‖Private Practice, Old Metairie Dermatology, Metairie, Louisiana.
    Background: Hair transplant surgery creates consistently natural appearing transplanted hair for men. It is increasingly popular procedure to restore natural growing hair for men with hair loss.

    Objective: To review some current controversies in hair transplant surgery. Read More

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