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    Induction and Maintenance Immunosuppression Treatment of Proliferative Lupus Nephritis: A Network Meta-analysis of Randomized Trials.
    Am J Kidney Dis 2017 Feb 20. Epub 2017 Feb 20.
    Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia; Diaverum Medical Scientific Office and Diaverum Academy, Lund, Sweden; Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy. Electronic address:
    Background: Intravenous (IV) cyclophosphamide has been first-line treatment for inducing disease remission in lupus nephritis. The comparative efficacy and toxicity of newer agents such as mycophenolate mofetil (MMF) and calcineurin inhibitors are uncertain.

    Study Design: Network meta-analysis. Read More

    Escalating dosimetry of UVA-1 in the treatment of alopecia areata.
    Int J Dermatol 2017 Feb 23. Epub 2017 Feb 23.
    Dermatology Department, Universidad Autonoma de Nuevo Leon, Facultad de Medicina, University Hospital, Monterrey, Mexico.
    Background: Phototherapy can be an option in unresponsive alopecia areata (AA); however, variable results have been reported with its use. We could not find literature of treatment with UVA-1 in AA. A study was designed to evaluate progressive dosimetry to determine the initial dose and its increments. Read More

    Dermoscopic Findings of Scalp Aplasia Cutis Congenita.
    Skin Appendage Disord 2017 Jan 8;2(3-4):177-179. Epub 2016 Dec 8.
    Hair and Scalp Diseases, Outpatient Clinic, Division of Dermatology, Santa Casa de Misericórdia, Porto Alegre, Brazil.
    Aplasia cutis congenita (ACC) is a rare disease characterized by congenital absence of skin, affecting preferentially the scalp. Diagnosis is made clinically; however, recent studies have shown that dermoscopy can be a useful tool for the diagnosis and differentiation from sebaceous nevus. The clinical findings include a shiny atrophic alopecic patch associated with dermoscopic findings of absent follicular openings, thicker vessels and a distinct collar hypertrichosis. Read More

    Frontal Fibrosing Alopecia Coexisting with Lupus Erythematosus: Poor Response to Hydroxychloroquine.
    Skin Appendage Disord 2017 Jan 12;2(3-4):162-165. Epub 2016 Nov 12.
    Dermatology Clinic, Hospital do Servidor Público Municipal de São Paulo, São Paulo, Brazil.
    Lupus erythematosus, especially the discoid form, and lichen planopilaris may be associated and can occur in different topographies (coexistence) or in the same lesion (lupus eythematosus/lichen planus overlap syndrome). Frontal fibrosing alopecia is considered a variant form of lichen planopilaris and is characterized by frontotemporal hairline and eyebrow involvement. Of the association with lupus erythematosus we have only a few descriptions. Read More

    Frontal Fibrosing Alopecia and Vitiligo: Coexistence or True Association?
    Skin Appendage Disord 2017 Jan 3;2(3-4):152-155. Epub 2016 Nov 3.
    2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, "Attikon" General University Hospital, Athens, Greece.
    Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia characterized by a progressive band-like recession of the frontotemporal hairline and frequent loss of the eyebrows. It predominantly affects postmenopausal women. Coexistence of FFA and vitiligo is rarely reported in the literature. Read More

    Clinical Evidence of Increase in Hair Growth and Decrease in Hair Loss without Adverse Reactions Promoted by the Commercial Lotion ECOHAIR®.
    Skin Pharmacol Physiol 2017 Feb 23;30(1):46-54. Epub 2017 Feb 23.
    Facultad de Farmacia y Bioquímica, Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina.
    Background/aims: Hair exerts protection, sensory functions, thermoregulation, and sexual attractiveness. Hair loss (alopecia) is caused by several diseases, drug intake, hormone imbalance, stress, and infections (Malassesia furfur). Drugs usually used in alopecia produce irreversible systemic and local side effects. Read More

    Do you know this syndrome? Hand-foot syndrome.
    An Bras Dermatol 2017 Jan-Feb;92(1):131-133
    Department of Dermatology and Radiotherapy, Medical School of Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp) - Botucatu (SP), Brazil.
    Hand-foot syndrome is a common cutaneous adverse effect associated with certain systemic chemotherapy drugs. It is characterized by erythema, edema, and burning sensation, especially over palmoplantar surfaces. We report the case of an elderly patient undergoing chemotherapy after a breast cancer surgery who developed symptoms two months after the start of the regimen. Read More

    Trichotillomania: a case report with clinical and dermatoscopic differential diagnosis with alopecia areata.
    An Bras Dermatol 2017 Jan-Feb;92(1):118-120
    Department of Dermatology of the Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.
    Trichotillomania is a psychodermatologic disorder characterized by uncontrollable urge to pull one's own hair. Differential diagnoses include the most common forms of alopecia such as alopecia areata. It is usually associated with depression and obsessive-compulsive disorder. Read More

    Frequency, severity and related factors of androgenetic alopecia in dermatology outpatient clinic: hospital-based cross-sectional study in Turkey.
    An Bras Dermatol 2017 Jan-Feb;92(1):35-40
    Department of Dermatology - Sisli Hamidiye Etfal Training and Research Hospital - Istanbul, Turkey.
    Background:: Androgenetic alopecia (AGA) is a patterned hair loss occurring due to systemic androgen and genetic factors. It is the most common cause of hair loss in both genders. In recent years, many studies investigating the relation between systemic diseases and androgenetic alopecia presented controversial results. Read More

    What people with Down Syndrome can teach us about cardiopulmonary disease.
    Eur Respir Rev 2017 Jan 21;26(143). Epub 2017 Feb 21.
    Dept of Bioengineering, University of Colorado Denver, Aurora, CO, USA
    Down syndrome is the most common chromosomal abnormality among live-born infants. Through full or partial trisomy of chromosome 21, Down syndrome is associated with cognitive impairment, congenital malformations (particularly cardiovascular) and dysmorphic features. Immune disturbances in Down syndrome account for an enormous disease burden ranging from quality-of-life issues (autoimmune alopecia) to more serious health issues (autoimmune thyroiditis) and life-threatening issues (leukaemia, respiratory tract infections and pulmonary hypertension). Read More

    Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo.
    Skin Pharmacol Physiol 2017 Feb 22;30(1):42-45. Epub 2017 Feb 22.
    Department of Surgery/Dermatology, Carol Davila University, Bucharest, Romania.
    Finasteride has proved to be relatively safe and effective in the therapeutic management of male androgenic alopecia. However, literature data report several endocrine imbalances inducing various adverse effects, which often persist after treatment cessation in the form of post-finasteride syndrome. Here we present the case of a 52-year-old man receiving finasteride (1 mg/day) who developed an uncommon adverse effect represented by generalized vitiligo 2 months after finasteride discontinuation. Read More

    The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study.
    Dermatol Surg 2017 Feb 17. Epub 2017 Feb 17.
    *Department of Dermatology, BTI Biotechnology Institute, Vitoria, Spain; †Eduardo Anitua Foundation, Vitoria, Álava, Spain; ‡Clínica Dermatológica, Vitoria, Spain.
    Background: Autologous growth factors have proved to promote tissue regeneration in various medical fields. Recent findings suggest that platelet rich plasma may also play an important role in hair follicle restoration.

    Objective: The objective of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGFs) for the treatment of androgenetic alopecia (AGA). Read More

    The Hair Shedding Visual Scale: A Quick Tool to Assess Hair Loss in Women.
    Dermatol Ther (Heidelb) 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Avenue Suite 2175, Miami, FL, USA.
    Introduction: Hair shedding is a common consequence of the normal hair cycle that changes with internal and external factors. Female pattern hair loss (FPHL) is difficult to assess in terms of shedding severity as the conscious perception of hair shedding varies according to each individual, and most utilized methods are semi-invasive or very time consuming. In this study, we establish and validate a hair-shedding scale for women with thick hair of different lengths. Read More

    Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems.
    Int J Mol Sci 2017 Feb 14;18(2). Epub 2017 Feb 14.
    Plastic and Reconstructive Surgery Department, University of Rome Tor Vergata, Via Courmayeur, No. 102, 00135 Rome, Italy.
    Platelet rich plasma (PRP) was tested as a potential therapy for androgenetic alopecia (AGA) through two different clinical protocols in which one population (18 participants) received half-head treatment with autologous non-activated PRP (A-PRP) produced by CPunT Preparation System (Biomed Device, Modena, Italy) and the other half-head with placebo, and a second separated population in which all participants (n = 6, 3 participants per group) received treatment with calcium-activated PRP (AA-PRP) produced from one of two different PRP collection devices (Regen Blood Cell Therapy or Arthrex Angel System). For the A-PRP study, three treatments were administered over 30-day intervals. Trichoscan analysis of patients, three months post-treatment, showed a clinical improvement in the number of hairs in the target area (36 ± 3 hairs) and in total hair density (65±  5 hair cm2), whereas negligible improvements in hair count (1. Read More

    Erosive pustular dermatosis of the scalp: Clinical, trichoscopic, and histopathologic features of 20 cases.
    J Am Acad Dermatol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Specialized, Clinical, and Experimental Medicine, Division of Dermatology, University of Bologna, Bologna, Italy.
    Background: Erosive pustular dermatosis of the scalp is a chronic eruption that leads to scarring alopecia.

    Objective: The clinical, dermoscopic, and histopathological features and the course of the disease in 20 patients were reviewed and compared with the reports in the literature.

    Methods: Gender, age at diagnosis, age at onset, duration, topography, predisposing factors, concomitant diseases, trichoscopy, histology, treatment, and outcome were taken into consideration. Read More

    [Psychosomatic disorders of the scalp].
    Hautarzt 2017 Feb 17. Epub 2017 Feb 17.
    Vivantes Netzwerk für Gesundheit GmbH, Klinik für Dermatologie und Allergologie, Immunonkologisches Zentrum, Schwerpunkt Männermedizin, Vivantes Klinikum Spandau, Akademisches Lehrkrankenhaus, Charité - Universitätsmedizin Berlin, Neue Bergstr. 6, 13585, Berlin, Deutschland.
    Psychosomatic disorders of the scalp have some special characteristics due to the visibility, possible stigmatization, and amount/patterns of hair. Of practical relevance is trichotillomania, which is now classified as an obsessive-compulsive disorder (OCD). Patients who are obsessed with normal physiological hair loss represent a further psychodermatological challenge. Read More

    Diffuse scarring alopecia in a female pattern hair loss distribution.
    Australas J Dermatol 2017 Feb 17. Epub 2017 Feb 17.
    Dermatology Department, Royal Newcastle Centre, Sydney, Newcastle, New South Wales, Australia.
    We describe three cases of hair loss in a female pattern hair loss (FPHL) distribution with histologic features of lichen planopilaris (LPP). All patients had a history of diffuse, gradual hair loss in a Christmas tree pattern that clinically presented as FPHL on gross and dermoscopic examination. Notably, there were no characteristic clinical signs of LPP and no histologic features of FPHL. Read More

    Cataracts and strabismus associated with hand rearing using artificial milk formulas in Bengal tiger (Panthera tigris spp tigris) cubs.
    Open Vet J 2017 31;7(1):23-31. Epub 2017 Jan 31.
    Universidade Federal do Paraná (UFPR), Departamento de Medicina Veterinária, Rua dos Funcionários, 1540, Bairro Juvevê, 80035-050, Curitiba - PR, Brazil.
    The aim of this investigation is to describe the potential contributing nutritional factors involved in the development of ophthalmic and dermatologic changes in four Bengal tiger (Panthera tigris spp tigris) cubs fed an artificial milk formula. The affected animals were compared with two other tiger cubs that had been nursed by their dam naturally. After the first clinical signs appeared, the tiger cubs underwent ophthalmic evaluation. Read More

    Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.
    Aging (Albany NY) 2017 Feb 15. Epub 2017 Feb 15.
    The Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden.
    MtDNA mutator mice exhibit marked features of premature aging. We find that these mice treated from age of ≈100 days with the mitochondria-targeted antioxidant SkQ1 showed a delayed appearance of traits of aging such as kyphosis, alopecia, lowering of body temperature, body weight loss, as well as ameliorated heart, kidney and liver pathologies. These effects of SkQ1 are suggested to be related to an alleviation of the effects of an enhanced reactive oxygen species (ROS) level in mtDNA mutator mice: the increased mitochondrial ROS released due to mitochondrial mutations probably interact with polyunsaturated fatty acids in cardiolipin, releasing malondialdehyde and 4-hydroxynonenal that form protein adducts and thus diminishes mitochondrial functions. Read More

    Noninvasive imaging of human immune responses in a human xenograft model of graft-versus-host disease.
    J Nucl Med 2017 Feb 16. Epub 2017 Feb 16.
    Whitehead Institute for Biomedical Research, United States.
    The immune system plays a crucial role in many diseases. Activation or suppression of immunity is often related to clinical outcome. Methods to explore the dynamics of immune responses are important to elucidate their role in conditions characterized by inflammation, such as infectious disease, cancer or auto-immunity. Read More

    Quality of life assessment in patients with alopecia areata and androgenetic alopecia in the People's Republic of China.
    Patient Prefer Adherence 2017 27;11:151-155. Epub 2017 Jan 27.
    Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
    Introduction: In medical terms, alopecia is considered a relatively mild dermatological condition that nevertheless is a serious condition, but it causes major depression in many sufferers. Alopecia areata (AA) and androgenetic alopecia (AGA) are the main types of hair loss. This study assessed the quality of life (QoL) of Chinese patients with AA and AGA using the Dermatology Life Quality Index (DLQI) questionnaire. Read More

    [The alpha-herpesviridae in dermatology : Varicella zoster virus. German version].
    Hautarzt 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgien.
    The second part of this publication deals with varicella zoster virus (VZV) and presents an overview of new, rare, and atypical clinical manifestations, including photolocalized varicella, hemorrhagic bullae during varicella, the implication of VZV in immunoglobulin A vasculitis, VZV-related alopecia, ulcerative varicella skin lesions, childhood herpes zoster (HZ), prolonged prodromal pains, recurrent HZ, VZV implication in burning mouth syndrome, verruciform VZV lesions, the significance of satellite lesions during HZ, and late HZ complications, either neurological or internal. Furthermore, certain associations between the occurrence of HZ and subsequent internal pathologies, as well as risk factors for HZ and new developments in vaccination against HZ will be addressed. Read More

    The alpha-herpesviridae in dermatology : Varicella zoster virus.
    Hautarzt 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgium.
    The second part of this publication deals with varicella zoster virus (VZV) and presents an overview of new, rare, and atypical clinical manifestations, including photolocalized varicella, hemorrhagic bullae during varicella, the implication of VZV in immunoglobulin A vasculitis, VZV-related alopecia, ulcerative varicella skin lesions, childhood herpes zoster (HZ), prolonged prodromal pains, recurrent HZ, VZV implication in burning mouth syndrome, verruciform VZV lesions, the significance of satellite lesions during HZ, and late HZ complications, either neurological or internal. Furthermore, certain associations between the occurrence of HZ and subsequent internal pathologies, as well as risk factors for HZ and new developments in vaccination against HZ will be addressed. Read More

    Association Between Use of a Scalp Cooling Device and Alopecia After Chemotherapy for Breast Cancer.
    JAMA 2017 02;317(6):606-614
    Weill Cornell Medical College, New York, New York.
    Importance: Chemotherapy-induced alopecia is a common and distressing adverse effect. In previous studies of scalp cooling to prevent chemotherapy-induced alopecia, conclusions have been limited.

    Objectives: To evaluate whether use of a scalp cooling system is associated with a lower amount of hair loss among women receiving specific chemotherapy regimens for early-stage breast cancer and to assess related changes in quality of life. Read More

    Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial.
    JAMA 2017 02;317(6):596-605
    Baylor College of Medicine, Houston, Texas.
    Importance: Chemotherapy may induce alopecia. Although scalp cooling devices have been used to prevent this alopecia, efficacy has not been assessed in a randomized clinical trial.

    Objectives: To assess whether a scalp cooling device is effective at reducing chemotherapy-induced alopecia and to assess adverse treatment effects. Read More

    Enhanced Expansion and Sustained Inductive Function of Skin-Derived Precursor Cells in Computer-Controlled Stirred Suspension Bioreactors.
    Stem Cells Transl Med 2017 Feb 9;6(2):434-443. Epub 2016 Sep 9.
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
    Endogenous dermal stem cells (DSCs) reside in the adult hair follicle mesenchyme and can be isolated and grown in vitro as self-renewing colonies called skin-derived precursors (SKPs). Following transplantation into skin, SKPs can generate new dermis and reconstitute the dermal papilla and connective tissue sheath, suggesting they could have important therapeutic value for the treatment of skin disease (alopecia) or injury. Controlled cell culture processes must be developed to efficiently and safely generate sufficient stem cell numbers for clinical use. Read More

    Acquired Hair Curling after Diphenylcyclopropenone Immunotherapy in Alopecia Areata Patient.
    J Eur Acad Dermatol Venereol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Contact immunotherapy using diphenylcyclopropenone (DPCP) is commonly used treatment modality for moderate to severe alopecia areata (AA)(1) . The most common side effects associated with topical immunotherapy using DPCP include eczema, hyperpigmentation, hypopigmentation, vitiligo, and cicatricial alopecia. However, we identified an interesting case of a patient whose entire scalp of straight hair (Figure 1A) became curly after DPCP immunotherapy, which has not been reported previously. Read More

    Risk of Distinctive Hair Changes Associated With Pazopanib in Patients With Renal Cell Carcinoma (RCC) Versus Patients Without RCC: A Comparative Systematic Review and Meta-analysis.
    Clin Genitourin Cancer 2017 Jan 12. Epub 2017 Jan 12.
    Ain Shams University, Faculty of Medicine, Cairo, Egypt.
    Objective: This systematic review and meta-analysis was accomplished with the purpose of evaluating the risk of encountering selected hair changes in patients with cancer receiving pazopanib.

    Methods: We favored relevant prospective randomized phase II and III trials that assessed pazopanib in patients with cancer, depicting various hair-related changes, as eligible for inclusion.

    Results: After elimination of ineligible studies, a total of 11 clinical trials were regarded as eligible for the meta-analysis. Read More

    Biological dose-escalated definitive radiation therapy in head and neck cancer.
    Br J Radiol 2017 Feb 10:20160477. Epub 2017 Feb 10.
    5 Medical Physics Department, Portuguese Oncology Institute of Coimbra Francisco Gentil, Coimbra, Portugal.
    Objective: To compare treatment outcome of patients with head and neck (HN) tumours treated with definitive Radiation Therapy (RT) that, mainly due to differences in the fractionation scheme used with simultaneous integrated boost techniques, resulted in a different biological dose.

    Methods: 181 HN cancer patients, prescribed to about 70.2 Gy in the primary tumour, were included in this study. Read More

    Differential pharmacology and clinical utility of sonidegib in advanced basal cell carcinoma.
    Onco Targets Ther 2017 24;10:515-520. Epub 2017 Jan 24.
    Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia.
    Patients suffering from advanced basal cell carcinoma (BCC) have very limited treatment options. Sonidegib selectively inhibits the growth of Hedgehog pathway-dependent tumors and can treat locally advanced BCC patients who are not candidates for surgery or radiation therapy. The BOLT clinical trials were conducted to evaluate the efficacy/potency of sonidegib in the treatment of advanced BCC or metastatic BCC. Read More

    Transarterial chemoembolization (TACE) combined with sorafenib versus TACE for hepatocellular carcinoma with portal vein tumor thrombus: a systematic review and meta-analysis.
    Oncotarget 2017 Feb 3. Epub 2017 Feb 3.
    Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University. Shanghai, China.
    Background: The benefits of transarterial chemoembolization plus sorafenib (TACE-S) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) remain controversial. We compared the effectiveness and safety of TACE-S and TACE for HCC with PVTT.

    Methods: The Cochrane Library, PubMed, EMBASE, Chinese National Knowledge Infrastructure, VIP, Wan Fang, and Sino Med databases were systematically searched for studies of HCC with PVTT treated using TACE-S. Read More

    Janus kinase inhibitors in dermatology: A systematic review.
    J Am Acad Dermatol 2017 Feb 3. Epub 2017 Feb 3.
    Department of Dermatology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel. Electronic address:
    Background: Janus kinase (JAK) inhibitors are emerging as a promising new treatment modality for many inflammatory conditions.

    Objective: Our aim was to systematically review the available data on the use of JAK inhibitors in cutaneous diseases.

    Methods: This is a systematic review of PubMed and ClinicalTrials. Read More

    The role of hydroxychloroquine in the treatment of lichen planopilaris: A retrospective case series and review.
    Dermatol Ther 2017 Feb 6. Epub 2017 Feb 6.
    Department of Dermatology, University Hospital Galway, Galway, Ireland.
    A variety of systemic agents are used to treat lichen planopilaris (LPP) with a limited evidence base. The aim of our study was to retrospectively review the response rate to and tolerability of hydroxychloroquine in a cohort of patients with LPP in an effort to add to the evidence base for its use. Twenty-three patients with a clinical and histopathological diagnosis of LPP who had been treated with hydroxychloroquine for their disease in a single center were identified. Read More

    Gsdma3 is required for mammary gland development in mice.
    Histochem Cell Biol 2017 Feb 6. Epub 2017 Feb 6.
    Department of Cell Biology, Third Military Medical University, Chongqing, 400038, China.
    AE (alopecia and excoriation) is a mouse mutant phenotype that harbours a mutation in Gsdma3. Gsdma3 has been reported to regulate the development of skin and hair follicles. However, its role in the mammary glands has not been reported. Read More

    Carbon dioxide laser ablation for trichoepitheliomas: the largest reported series.
    J Cosmet Laser Ther 2017 Feb 6. Epub 2017 Feb 6.
    c St. John's Institute of Dermatology , St. Thomas' Hospital , London , United Kingdom of Great Britain and Northern Ireland.
    Trichoepitheliomas are benign cutaneous tumours often occurring on the face and can lead to considerable psychological distress to its sufferers. Treatment is often difficult and surgery is limited by the obvious scars and multiple number of lesions. Carbon dioxide laser ablation can be used safely with good cosmetic outcome and low recurrence rate and in this article we describe our experience in the treatment of these tumours with the carbon dioxide laser. Read More

    Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders.
    Int J Mol Sci 2017 Feb 3;18(2). Epub 2017 Feb 3.
    Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea.
    Erythroid differentiation regulator 1 (Erdr1) is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Read More

    Skin depigmentation associated with toceranib phosphate in a dog.
    Vet Dermatol 2017 Feb 6. Epub 2017 Feb 6.
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 220 Trowbridge Road, East Lansing, MI, 48824, USA.
    Background: Drug-induced depigmentation is frequently observed in humans undergoing tyrosine kinase inhibitor therapy, whereas it is not reported in dogs. The skin depigmentation can occur after the first week of treatment and it is reversible within a few weeks after drug discontinuation.

    Objectives: To report the clinical and histopathological features of an episode of cutaneous adverse drug reaction associated with short term administration of toceranib phosphate. Read More

    Short stature and growth hormone deficiency in a girl with encephalocraniocutaneous lipomatosis and Jaffe-Campanacci syndrome: a case report.
    Ann Pediatr Endocrinol Metab 2016 Dec 31;21(4):240-244. Epub 2016 Dec 31.
    Department of Pathology, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
    A 9-year-old Tajikistani girl presented to Keimyung University Dongsan Medical Center for evaluation of a skin lesion on her left eyelid, focal alopecia, unilateral ventricular dilatation, and aortic coarctation. She was diagnosed with encephalocraniocutaneous lipomatosis (ECCL) according to Moog's diagnostic criteria. Café-au-lait spots were found on the left side of her trunk. Read More

    Long-term sequelae of chikungunya virus disease: A systematic review.
    Travel Med Infect Dis 2017 Feb 2. Epub 2017 Feb 2.
    Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, DD1100 Amsterdam, The Netherlands. Electronic address:
    Background: The acute phase of chikungunya is well documented; less so are its long-term effects. This systematic literature review provides an overview of the currently available data.

    Methods: We performed an electronic search in PubMed/Medline and checked reference lists. Read More

    Safety Profile of Finasteride: Distribution of Adverse Effects According to Structural and Informational Dichotomies of the Mind/Brain.
    Clin Drug Investig 2017 Feb 4. Epub 2017 Feb 4.
    Department of Urology, Carol Davila University, Bucharest, Romania.
    Finasteride is currently used extensively for male androgenic alopecia and benign prostatic hyperplasia; however, some adverse effects are severe and even persistent after treatment cessation, the so-called 'post-finasteride syndrome'. The following most severe adverse effects-sexual dysfunction and depression-often occur together and may potentiate one other, a fact that could explain (at least in part) the magnitude and persistence of finasteride adverse effects. This paper presents the pharmacological action of finasteride and the corresponding adverse effects, the biological base explaining the occurrence, persistence and distribution of these adverse effects, and a possible therapeutic solution for post-finasteride syndrome. Read More

    Hair loss at injection sites of mesotherapy for alopecia.
    J Cosmet Dermatol 2017 Feb 3. Epub 2017 Feb 3.
    Faculty of Medicine, Cairo University, Cairo, Egypt.
    Background: The side effects of mesotherapy for treatment of various forms of alopecia are often underreported, while scientific data for its efficacy are severely lacking.

    Objective: To demonstrate the late onset side effects of mesotherapy for alopecia.

    Methods: Three patients with androgenetic alopecia showed hair loss after previously uneventful mesotherapy sessions up to 1 year. Read More

    Eradication of damaged keratinocytes in cutaneous lichen planus forms demonstrated by evaluation of epidermal and follicular expression of CK15, indices of apoptosis and regulatory protein S100.
    Pol J Pathol 2016 ;67(3):258-269
    Department of Physics, Riga Stradins University, Riga, Latvia.
    The study of cytoskeleton arrangement and its contribution to survival of cell-to-cell contacts appears to be essential for understanding of numerous cellular and tissue processes. Applying CK15, S100 labeling and TUNEL reaction to cutaneous lichen planus subtypes, we found CK15 expression in the outer and inner root sheath of hair follicles, the basal epidermal layer, and eccrine glands. Its follicular expression was decreased in nearby inflammatory infiltrates. Read More

    Chemotherapy-induced alopecia management: Clinical experience and practical advice.
    J Cosmet Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Dermatology, "Sapienza" University of Rome, II School, Rome, Italy.
    Background: Chemotherapy-induced alopecia (CIA) is probably one of the most shocking aspects for oncological patients and underestimated by physicians. Among hair loss risk factors, there are treatment-related aspects such as drug dose, administration regimen, and exposure to X-rays, but also patient-related characteristics. To the best of our knowledge, no guidelines are available about CIA management. Read More

    Changes of serum trace elements level in patients with alopecia areata: A meta-analysis.
    J Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Dermatology and Venerology, No. 2 Hospital of Jilin University, Changchun, China.
    Abnormalities of serum trace elements are involved in the etiology and pathogenesis of alopecia areata (AA); however, the results of published studies are controversial. The purpose of the present study is to investigate the alterations of serum level of trace elements and AA using a meta-analysis approach. We searched all articles indexed in PubMed, Embase and Science Citation Index published up to 30 April 2016 concerning the association between serum level of zinc, copper, iron/ferritin, selenium or magnesium and AA. Read More

    Systemic granulomatous and haemorrhagic syndrome in New Zealand dairy cattle.
    N Z Vet J 2017 Feb 1:1-25. Epub 2017 Feb 1.
    f Gribbles Veterinary Pathology , Christchurch , New Zealand.
    Case History: Cases were obtained through passive surveillance reporting by veterinary pathologists, via the Ministry for Primary Industries Exotic Pest and Disease Hotline. They included ill or dead cows that had evidence of frank haemorrhage, petechial haemorrhages on mucous membranes, wasting or dermatitis of unknown cause, and were reported between 2009-2014. Affected cows (n=16) were from nine seasonally calving dairy farms, aged ≥3 years, and were predominantly in their mid-to-late non-lactating period. Read More

    Interleukin-31 Pathway and its Role in Atopic Dermatitis: A Systematic Review.
    J Dermatolog Treat 2017 Feb 1:1-28. Epub 2017 Feb 1.
    a Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine , Winston-Salem , North Carolina.
    Background: Atopic dermatitis, a chronic inflammatory disease, has a lifetime prevalence of 10-20%. Atopic dermatitis reduces quality of life, primarily due to pruritus. Interleukin-31 and its target receptor are newly discovered entities that are involved in pruritus. Read More

    A case report of coup de sabre patient with hair transplantation.
    J Dermatolog Treat 2017 Jan 31:1-6. Epub 2017 Jan 31.
    b Tongde Hospital of Zhejiang Province , Hangzhou , China.
    Background: Treatment of coup de sabre must remain conservative until the disease is no longer in an active state. When activity has ceased, some operative intervention is safe and effective for the correction of deformity. While hair transplantation showed high survival rates for the correction of cicatricial alopecia, it has rarely reported to be performed for the correction of coup de sabre. Read More

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