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    1 OF 386

    Infectious diseases causing autonomic dysfunction.
    Clin Auton Res 2017 Jul 20. Epub 2017 Jul 20.
    Neurology Department, Raigmore Hospital, Inverness, UK.
    Objectives: To review infectious diseases that may cause autonomic dysfunction.

    Methods: Review of published papers indexed in medline/embase.

    Results: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Read More

    Severe cyclophosphamide-related hyponatremia in a patient with acute glomerulonephritis.
    World J Nephrol 2017 Jul;6(4):217-220
    Pasquale Esposito, Maria Valentina Domenech, Nicoletta Serpieri, Marta Calatroni, Ilaria Massa, Alessandro Avella, Edoardo La Porta, Luca Estienne, Elena Caramella, Teresa Rampino, Department of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico "San Matteo" and University of Pavia, 27100 Pavia, Italy.
    Cyclophosphamide is frequently used to treat cancer, autoimmune and renal diseases, such as rapidly progressive glomerulonephritis. Its side effects are well-known, including bone marrow depression, infections, alopecia, sterility, bladder malignancy and hemorrhagic cystitis. Moreover, in some cases cyclophosphamide use has been related to the onset of hyponatremia, by development of a syndrome of inappropriate antidiuresis. Read More

    Thermal imaging and dermoscopy for detecting inflammation in frontal fibrosing alopecia.
    J Cosmet Dermatol 2017 Jul 20. Epub 2017 Jul 20.
    Chair and Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
    Background: Frontal fibrosing alopecia (FFA) is an inflammatory condition of the scalp, which leads to scarring and slowly progressive recession of frontotemporal and/or frontoparietal hairline. Choice of FFA treatment is highly dependent on accurate assessment of disease phase, as medical treatments are effective only during the initial inflammatory stage.

    Methods: To objectively quantify the activity of the inflammatory process in FFA, 22 female patients were examined by both infrared thermography and optical dermoscopy before tissue sampling. Read More

    Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss.
    Stem Cell Investig 2017 27;4:58. Epub 2017 Jun 27.
    Department of Plastic and Reconstructive Surgery, University of Rome "Tor Vergata" School of Medicine, Rome 00173, Italy.
    Background: Hair follicles are known to contain a well-characterized niche for adult stem cells: the bulge, which contains epithelial and melanocytic stem cells. Stem cells in the hair bulge, a clearly demarcated structure within the lower permanent portion of hair follicles, can generate the interfollicular epidermis, hair follicle structures, and sebaceous glands. The bulge epithelial stem cells can also reconstitute in an artificial in vivo system to a new hair follicle. Read More

    Cronkhite-Canada Syndrome: A Rare Cause of Chronic Diarrhea.
    Gastroenterology Res 2017 Jun 30;10(3):196-198. Epub 2017 Jun 30.
    Bassett Medical Center, Cooperstown, NY, USA.
    Cronkhite-Canada syndrome (CCS) is a rare non-hereditary disease characterized by chronic diarrhea, diffuse intestinal polyposis and onychodystrophy. We present here a case of a middle-aged female who presented with chronic intermittent bloody diarrhea associated alopecia and loss of finger and toe nails. Labs were remarkable for microcytic anemia and severe hypoalbuminemia. Read More

    Two years results of electronic brachytherapy for basal cell carcinoma.
    J Contemp Brachytherapy 2017 Jun 5;9(3):251-255. Epub 2017 Jun 5.
    Dermatology Department.
    Purpose: The use of radiation therapy (RT) for non-melanoma skin cancer (NMSC) has been changing throughout the last century. Over the last decades, the use of radiotherapy has surged with the development of new techniques, applicators, and devices. In recent years, electronic brachytherapy (eBT) devices that use small x-ray sources have been introduced as alternative to radionuclide dependence. Read More

    Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats.
    Parasit Vectors 2017 Jul 19;10(1):341. Epub 2017 Jul 19.
    Ceva Santé Animale, 10 avenue de la Ballastière, 33500, Libourne, France.
    Background: The cat flea, Ctenocephalides felis felis (C. felis), is a cosmopolitan hematophagous ectoparasite, and is considered to be the most prevalent flea species in both Europe and the USA. Clinical signs frequently associated with flea bites include pruritus, dermatitis and in severe cases even pyodermatitis and alopecia. Read More

    [Mesotherapy in trichology].
    Cas Lek Cesk 2017 ;156(3):145-146
    Mesotherapy (from Greek meso = in between, therapeia = treat) is a non-surgical, mostly cosmetic therapy, where active substances are injected intradermally into a depth of about 4 mm. It is an effective and easy-to-use method in the treatment of alopecia. It is effective both in the therapy of androgenetic alopecia and telogen effluvium. Read More

    Nothing is more important than my partner's health: Turkish men's perspectives on partner's appearance after mastectomy and alopecia.
    Eur J Oncol Nurs 2017 Aug 10;29:23-30. Epub 2017 May 10.
    Gümüşhane University, Faculty of Health Sciences, Nursing Department, 29100 Gümüşhane, Turkey. Electronic address:
    Purposes: The aim of this study was to acquire a deeper understanding of male experiences on the emotional and social impact of their partners' mastectomy and chemotherapy-induced alopecia.

    Methods: A purposive sample of 16 males whose partners had undergone mastectomy and alopecia due to chemotherapy was chosen. The data were collected through a semi-structured interview method. Read More

    Alopecia Areata: a Comprehensive Review of Pathogenesis and Management.
    Clin Rev Allergy Immunol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Dermatology, Universidade Federal Fluminense, Centro de Ciências Médicas, Hospital Universitário Antonio Pedro, Niterói, Rio de Janeiro, Brazil.
    Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. The current understanding is that the condition represents an organ-specific autoimmune disease of the hair follicle with a genetic background. Read More

    Frontal fibrosing alopecia among men: A clinicopathologic study of 7 cases.
    J Am Acad Dermatol 2017 Jul 14. Epub 2017 Jul 14.
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
    Background: Frontal fibrosing alopecia (FFA) is a lichen planopilaris-variant scarring alopecia that has rarely been described in men.

    Objective: To characterize the clinicopathologic findings of FFA in men by studying a series of 7 male patients.

    Methods: We conducted a retrospective review of all cases of male patients with FFA at the Mayo Clinic from 1992 to 2016. Read More

    A novel pathogenic variant in an Iranian Ataxia telangiectasia family revealed by next-generation sequencing followed by in silico analysis.
    J Neurol Sci 2017 Aug 12;379:212-216. Epub 2017 Jun 12.
    Ahvaz Noor Genetics Laboratory, Ahvaz, Iran; Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:
    Ataxia telangiectasia (A-T) is a neurodegenerative autosomal recessive disorder with the main characteristics of progressive cerebellar degeneration, sensitivity to ionizing radiation, immunodeficiency, telangiectasia, premature aging, recurrent sinopulmonary infections, and increased risk of malignancy, especially of lymphoid origin. Ataxia Telangiectasia Mutated gene, ATM, as a causative gene for the A-T disorder, encodes the ATM protein, which plays an important role in the activation of cell-cycle checkpoints and initiation of DNA repair in response to DNA damage. Targeted next-generation sequencing (NGS) was performed on an Iranian 5-year-old boy presented with truncal and limb ataxia, telangiectasia of the eye, Hodgkin lymphoma, hyper pigmentation, total alopecia, hepatomegaly, and dysarthria. Read More

    Establishing and Prioritising Research Questions for the Prevention, Diagnosis and Treatment of Hair Loss (excluding Alopecia Areata): The Hair Loss Priority Setting Partnership.
    Br J Dermatol 2017 Jul 17. Epub 2017 Jul 17.
    University of Manchester, Salford Royal NHS Foundation Trust, The Dermatology Centre, Salford, Greater Manchester, UK.
    Background: Hair and scalp problems are common. Unfortunately, many uncertainties exist around the most effective management and treatments strategies for these disorders.

    Objectives: To identify uncertainties in hair loss management, prevention, diagnosis and treatment that are important to both people with hair loss and healthcare professionals. Read More

    Treatment of Nonclassic 11-Hydroxylase Deficiency with Ashwagandha Root.
    Case Rep Endocrinol 2017 20;2017:1869560. Epub 2017 Jun 20.
    Department of Medicine, New York City Health + Hospitals/Woodhull, 760 Broadway, Brooklyn, NY 11206, USA.
    An elderly woman presented with acne and male pattern alopecia, which upon diagnostic evaluation was found to be due to nonclassic 11-hydroxylase deficiency. We previously reported that Ashwagandha root ameliorates nonclassic 3-β-ol dehydrogenase and aldosterone synthase deficiencies. This is the first report of its use being associated with amelioration of nonclassic 11-hydroxylase deficiency, where its apparent effects appear to be dose-related. Read More

    Does a male polycystic ovarian syndrome equivalent exist?
    J Endocrinol Invest 2017 Jul 15. Epub 2017 Jul 15.
    Department of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", via S. Sofia 78, 95123, Catania, Italy.
    The occurrence of a genetic background in the etiology of polycystic ovarian syndrome (PCOS) represents the rational basis to postulate the existence of a male PCOS equivalent. Hormonal and metabolic abnormalities have been described in male relatives of women with PCOS. These males also have a higher prevalence of early onset (<35 years) androgenetic alopecia (AGA). Read More

    Typical and atypical clinical appearance of atopic dermatitis.
    Clin Dermatol 2017 Jul - Aug;35(4):354-359. Epub 2017 Mar 24.
    Icahn School of Medicine at Mt Sinai, New York, NY. Electronic address:
    Atopic dermatitis is a complex, systemic inflammatory disorder associated with a variety of clinical features. The original criteria of Hanifin and Rajka include major criteria and a list of about two dozen minor criteria however, even the minor criteria do not include some features of atopic dermatitis noted less commonly but still seen with some frequency. This contribution first reviews the common clinical appearance of atopic dermatitis in infancy, childhood, and adulthood, as well as the less typical appearances, including lichenoid atopic dermatitis; juvenile plantar dermatosis; nummular-type atopic dermatitis; follicular atopic dermatitis; alopecia of atopic dermatitis; eczema coxsackium; and psoriasiform, perineal, and lip licker's dermatitis. Read More

    Encephalocraniocutaneous lipomatosis: A case report with review of literature.
    Neuroradiol J 2017 Jan 1:1971400917693638. Epub 2017 Jan 1.
    1 Department of Radiodiagnosis, Jawaharlal Nehru Medical College, Aligarh Muslim University, India.
    Encephalocraniocutaneous lipomatosis (ECCL) or Haberland syndrome is an uncommon sporadic neurocutaneous syndrome of unknown origin. The rarity and common ignorance of the condition often makes diagnosis difficult. The hallmark of this syndrome is the triad of skin, ocular and central nervous system (CNS) involvement and includes a long list of combination of conditions. Read More

    Lichenoid Dermatitis in an Adult with Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome.
    Skinmed 2017 1;15(3):231-234. Epub 2017 Jun 1.
    Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.
    A 23-year-old man presented to our practice with erythroderma and an unusual retiform eruption, along with alopecia universalis and nail dystrophy. He had had no skin findings at birth, but since early infancy had had localized eczematous eruptions of his skin. At 10 years of age, he had developed a generalized eczematous flare requiring hospitalization, and another generalized episode occurred in October 2010. Read More

    Long-Term Prognosis of Alopecia Totalis and Alopecia Universalis: A Longitudinal Study with More than 10 Years of Follow-Up: Better than Reported.
    Dermatology 2017 Jul 14. Epub 2017 Jul 14.
    Department of Dermatology, Kyungpook National University School of Medicine, Daegu, South Korea.
    Background: In alopecia totalis (AT) and alopecia universalis (AU), the chance of full hair regrowth is known to be less than 10%. However, this information is based on a few older studies conducted in the 1950s and 1960s.

    Objective: We investigated the current long-term prognosis of individuals with AT/AU. Read More

    The evolution of artificial hair implantation.
    J Biol Regul Homeost Agents 2017 07 13;31(2 Suppl. 2). Epub 2017 Jul 13.
    Chair of Dermatology, University of Rome “G. Marconi”, Rome, Italy.
    From the beginning, artificial hair implantation has aroused a lot of interest, sometimes controversial, in the field of hair restoration. The artificial fiber must be of high quality and biocompatible. Biofibre® is a very fine fiber having diameter of 80 m. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 07 13;31(2 Suppl. 2). Epub 2017 Jul 13.
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Ruxolitinib found to cause eyelash growth: a case report.
    J Med Case Rep 2017 Jul 12;11(1):189. Epub 2017 Jul 12.
    Center for Oculofacial & Orbital Surgery, 3771 Katella Ave., #209, Los Alamitos, CA, 90720, USA.
    Background: Hypereosinophilic syndrome is a hematologic disorder in which the eosinophils proliferate. Oral Janus kinase inhibitors are known to be effective treating hypereosinophilic syndrome. Janus kinase inhibitors have also demonstrated efficacy in alopecia. Read More

    Fatigue, alopecia and stomatitis among patients with breast cancer receiving cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis.
    Expert Rev Anticancer Ther 2017 Jul 20:1-6. Epub 2017 Jul 20.
    b Clinical Oncology Department, Faculty of Medicine , Aim Shams University , Cairo , Egypt.
    Background: Cyclin-dependent kinase (CDK) inhibitors emerge as efficacious agents in hormone positive metastatic breast cancer with more acceptable toxicity profiles than cytotoxic chemotherapy. However, some adverse effects such as fatigue, alopecia and stomatitis, vastly concern patients.

    Methods: The search was conducted in PubMed, American Society of Clinical Oncology meeting library, European Society for Medical Oncology meeting abstract, and the San Antonio meeting abstract databases. Read More

    Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia Areata.
    Open Access Maced J Med Sci 2017 Jun 11;5(3):305-309. Epub 2017 Jun 11.
    Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition.

    Aim: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals. Read More

    Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia.
    Sci Rep 2017 Jul 11;7(1):5102. Epub 2017 Jul 11.
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
    Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) is a rare disorder, caused by bialellic mutations of the vitamin D receptor (VDR) gene, sometimes associated with alopecia. The aim of this study is to elucidate the mechanism of functional disruption of a novel mutation, detected in a patient with HVDRR, comparing to other mutations with or without alopecia. The patient was a 2-year-old girl with alopecia, who was clinically diagnosed as HVDRR. Read More

    ADULT syndrome: dental features of a very rare condition.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):61-65
    Department of Medicine and Surgery, Research Centre into Paediatric Dentistry and Rare Syndromes, University of Insubria, ASST dei Sette Laghi, Dental Clinic, Varese, Italy.
    The Acro-Dermato-Ungual-Lacrimal-Tooth syndrome (ADULT syndrome) is one of the rarest ectodermal dysplasias and it is associated with several malformations involving especially the limbs. The most clinical features are the presence of ectrodactyly, syndactyly, hypermelanosis or multiple lentigines, onhycodysplasia, abnormalities in the lacrimal duct, recurrent conjuntivitis, photophobia, mammarian hypoplasia, hypotrichosis and frontal alopecia, hypohydrosis, cutaneous photosensitivity, nasal bridge prominence, exfoliative dermatitis and xerosis. The ectodermal dysfunction expresses itself with conoid teeth, enamel hypoplasia, dentinal dysplasia and especially hypodontia, with following functional and aesthetic defects. Read More

    Therapeutic experience with oral finasteride for androgenetic alopecia in female-to-male transgender patients.
    Clin Exp Dermatol 2017 Jul 10. Epub 2017 Jul 10.
    Dermatology Department, Hospital Universitario Ramon y Cajal, Madrid, Spain.
    Background: Androgenic treatment of female-to-male transgender patients may result in androgenetic alopecia (AGA). Use of 5-alpha-reductase inhibitors are useful as oral treatment of AA in men. There are no previous studies of the use of finasteride in transgender men as treatment of AGA. Read More

    Trichoscopic Findings of Erosive Pustular Dermatosis of the Scalp Associated with Gefitinib.
    Case Rep Dermatol 2017 May-Aug;9(2):44-49. Epub 2017 Jun 14.
    Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    Alopecia associated with epidermal growth factor receptor (EGFR) inhibitor therapy is a rare cutaneous side effect with the potential to progress to scarring alopecia. Thus, dermatologists should make an early diagnosis. We present the case of a 57-year-old Japanese female with scarring alopecia associated with gefitinib, which is an EGFR inhibitor, including trichoscopic findings. Read More

    Microneedling: Where do we stand now? A systematic review of the literature.
    J Plast Reconstr Aesthet Surg 2017 Jun 17. Epub 2017 Jun 17.
    Department of Plastic and Reconstructive Surgery - Burn Center, University Hospital of Ghent, De Pintelaan 185, 9000 Ghent, Belgium.
    Background: Patients who suffer from scars or wrinkles have several therapeutic options to improve the appearance of their skin. The available treatment modalities that provide desirable results are often overtly invasive and entail a risk of undesirable adverse effects. Microneedling has recently emerged as a non-ablative alternative for treating patients who are concerned with the aesthetic changes that result from injury, disease or ageing. Read More

    [Two cases of the rare Cronkhite-Canada syndrome].
    Ugeskr Laeger 2017 Jul;179(27)
    Cronkhite-Canada syndrome (CCS) is a rare non-heritable condition characterized by gastrointestinal polyposis, dysgeusia, malnutrition, total alopecia and onychodystrophia. Two Danish cases of CCS (an 88-year-old female and a 69-year-old male) presented with signs of malnutrition, dyspepsia, vomiting, dysgeusia and hair loss. An upper endoscopy revealed marked oedema and polyposis in the stomach. Read More

    Experimental and early investigational drugs for androgenetic alopecia.
    Expert Opin Investig Drugs 2017 Jul 12:1-16. Epub 2017 Jul 12.
    a Department of Dermatology and Skin Science , University of British Columbia , Vancouver , Canada.
    Introduction: Treatments for androgenetic alopecia constitute a multi-billion-dollar industry, however, currently available therapeutic options have variable efficacy. Consequently, in recent years small biotechnology companies and academic research laboratories have begun to investigate new or improved treatment methods. Research and development approaches include improved formulations and modes of application for current drugs, new drug development, development of cell-based treatments, and medical devices for modulation of hair growth. Read More

    Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia.
    Skin Pharmacol Physiol 2017 Jul 8;30(4):197-204. Epub 2017 Jul 8.
    CBiOS, Research Center for Biosciences and Health Technologies, Universidade Lusófona de Humanidades e Tecnologias, Universidade de Lisboa, Lisbon, Portugal.
    Background/aims: Androgenetic alopecia is an extremely common dermatological disorder affecting both men and women. Oral finasteride (FNS), a synthetic 4-aza-3-oxosteroid compound with poor aqueous solubility, blocks the peripheral conversion of testosterone to dihydrotestosterone (DHT) in a significant reduction in DHT concentration, achieving satisfactory results in alopecia treatment. However, its oral intake generally causes severe side effects. Read More

    Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?
    Bioessays 2017 Jul 7. Epub 2017 Jul 7.
    Centre for Dermatology Research, School of Biological Sciences, University of Manchester, Manchester, UK.
    Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition. Read More

    Unusual acute lupus hemophagocytic syndrome - a test of diagnostic criteria: a case report.
    J Med Case Rep 2017 Jul 7;11(1):185. Epub 2017 Jul 7.
    Postgraduate Institute of Medicine, University of Colombo, Colombo, Sri Lanka.
    Background: Hemophagocytic lymphohistiocytosis is an aggressive life-threatening syndrome of excessive immune activation. Hemophagocytic lymphohistiocytosis due to systemic lupus erythematosus is described as acute lupus hemophagocytic syndrome. Acute lupus hemophagocytic syndrome presenting with negative antinuclear antibody is uncommon. Read More

    Transgenic mice display hair loss and regrowth overexpressing mutant Hr gene.
    Exp Anim 2017 Jul 5. Epub 2017 Jul 5.
    Henan Academy of Medical and Pharmaceutical Sciences.
    Mutations in the hairless (Hr) gene in both mice and humans have been implicated in the development of congenital atrichia, but the role of Hr in skin and hair follicle (HF) biology remains unknown. Here, we established transgenic mice (TG) overexpressing mutant Hr to investigate its specific role in the development of HF. Three transgenic lines were successfully constructed, and two of them (TG3 and TG8) displayed a pattern of hair loss and regrowth with alternation in the expression of HR protein. Read More

    Injections of platelet-rich plasma for androgenic alopecia: A systematic review.
    J Stomatol Oral Maxillofac Surg 2017 Jul 1. Epub 2017 Jul 1.
    Department of Plastic & Reconstructive Surgery and Maxillo-Facial Surgery, Henri-Mondor Hospital, 51 avenue du Maréchal-de-Lattre-de-Tassigny, Créteil 94010, France.
    The aim of this literature review was to evaluate the effects of PRP injections into the scalp of patients with androgenic alopecia. A literature review was conducted using the Pubmed and Google Scholar databases with the search terms "platelet-rich plasma" or "platelet-rich fibrin" and "hair" or "alopecia" or "androgenic alopecia". The publications included had to clinically assess the efficacy of PRP injections in patients with androgenic alopecia. Read More

    Hair Follicle Generation by Injections of Adult Human Follicular Epithelial and Dermal Papilla Cells into Nude Mice.
    Cell J 2017 Jul-Sep;19(2):259-268. Epub 2017 Feb 22.
    Department of Regenerative Biomedicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
    Objective: Dermal papilla and hair epithelial stem cells regulate hair formation and the growth cycle. Damage to or loss of these cells can cause hair loss. Although several studies claim to reconstitute hairs using rodent cells in an animal model, additional research is needed to develop a stable human hair follicle reconstitution protocol. Read More

    25-hydroxyvitamin D status in patients with alopecia areata.
    Postepy Dermatol Alergol 2017 Jun 29;34(3):248-252. Epub 2017 May 29.
    Department of Dermatology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
    Introduction: Alopecia areata (AA) is a T cell-mediated autoimmune disease that causes inflammation around anagen-phase hair follicles. Insufficient levels of vitamin D have been implicated in a variety of autoimmune diseases.

    Aim: To investigate the status of serum 25-hydroxyvitamin D (25(OH)D) in patients with AA, serum 25(OH)D concentrations were compared between AA patients and healthy controls and thus determine if a possible association exists between serum 25(OH)D levels and AA. Read More

    Trichoscopy of scalp dysesthesia.
    Postepy Dermatol Alergol 2017 Jun 29;34(3):245-247. Epub 2017 May 29.
    Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
    Introduction: Scalp dysesthesia is characterized by localized pruritus, burning sensations or even pain.

    Aim: To describe characteristic trichoscopic features of scalp dysesthesia.

    Material And Methods: The study was a retrospective analysis (2010-2016) of 9 patients (8 females and 1 male; median age: 52 years; range: 38-66 years). Read More

    Single-Agent Oral Vinorelbine as First-Line Chemotherapy for Endocrine-Pretreated Breast Cancer With Bone Metastases and No Visceral Involvement: NORBREAST-228 Phase II Study.
    Clin Breast Cancer 2017 Jun 27. Epub 2017 Jun 27.
    Institut de Recherche Pierre Fabre, Boulogne-Billancourt Cédex, France.
    Purpose: Single-agent oral chemotherapy is widely used in patients with bone metastases without visceral involvement, especially in hormone receptor-positive metastatic breast cancer (mBC). However, this option has been poorly evaluated in clinical trials.

    Methods: Eligible patients had mBC with predominantly bone but not visceral metastases, were receiving bisphosphonate therapy, and had previously received endocrine therapy (any setting) but not chemotherapy for mBC. Read More

    The role of the zinc transporter SLC30A2/ZnT2 in transient neonatal zinc deficiency.
    Metallomics 2017 Jun 30. Epub 2017 Jun 30.
    The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion-Israel Institute of Technology, Haifa, 32000, Israel.
    Breast milk is the optimal nutrient mix for infants until the age of 6 months. However, in some cases, due to genetic alterations as well as nutrient deficiencies in nursing mothers, infants may suffer from inadequate levels of micronutrients upon exclusive breastfeeding. In this respect, transient neonatal zinc deficiency (TNZD) is caused by loss-of-function mutations in the zinc transporter SLC30A2/ZnT2 gene, resulting in poor secretion of zinc into the breast milk. Read More

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