22,379 results match your criteria Androgenetic Alopecia


Efficacy and safety of very low dose oral minoxidil 1.25mg in male androgenetic alopecia.

J Am Acad Dermatol 2020 May 31. Epub 2020 May 31.

Department of Dermatology & Dermoscopy, Skinnocence: the Skin Clinic & Research Centre, Gurugram, India. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.05.129DOI Listing

Onset of Schamberg's disease and resolution of alopecia areata during treatment of atopic dermatitis with dupilumab.

J Investig Allergol Clin Immunol 2020 Jun 3. Epub 2020 Jun 3.

Unit of Dermatology, University of Padua, Padua, Italy.

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http://dx.doi.org/10.18176/jiaci.0541DOI Listing

The impact of oxidative stress in androgenic alopecia in women.

Postepy Dermatol Alergol 2020 Feb 9;37(1):119-120. Epub 2020 Mar 9.

Department of Dermatology, Sexually Transmitted Disorders and Immunodermatology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

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http://dx.doi.org/10.5114/ada.2019.81685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247070PMC
February 2020

Dithranol: An insight on its novel delivery cargos for psoriasis management.

Curr Drug Res Rev 2020 May 25. Epub 2020 May 25.

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana. India.

Objective: Dithranol (DTH) is a promising well known moiety that has long been used to impede and treat skin disorders, particularly psoriasis. Now a days, a rekindled interest in the use of DTH for this disorder has been observed. Side effects associated with conventional topical formulations of this moiety have aroused interest of scientific community in novel cargos for psoriasis management. Read More

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http://dx.doi.org/10.2174/2589977512666200525154954DOI Listing

Scarring alopecia in chronic cutaneous lupus erythematosus with neutrophils: A new scenario with therapeutic connotations.

J Cutan Pathol 2020 Jun 1. Epub 2020 Jun 1.

Department of Dermatology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.

The relationship between autoinflammatory and autoimmune conditions has been demonstrated in recent decades. Several autoimmune conditions exhibit an autoinflammatory component, which can manifest in various ways. Neutrophilic dermatosis in the context of lupus erythematosus (LE) is one example. Read More

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http://dx.doi.org/10.1111/cup.13764DOI Listing

Limbal Stem Cell Dysfunction in Ichthyosis Follicularis, Alopecia, and Photophobia Syndrome.

Cornea 2020 May 29. Epub 2020 May 29.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.

Purpose: To describe the presentation and management of limbal stem cell dysfunction in ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome.

Methods: A retrospective case report.

Results: A 6-day-old male infant was diagnosed with IFAP syndrome based on family history and a mutation detected in the MBTPS2 gene. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002393DOI Listing

Dermatoscopic findings of syphilitic alopecia.

An Bras Dermatol 2020 May 11. Epub 2020 May 11.

Department of Dermatology and Radiotherapy, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo, SP, Brazil.

Syphilis is an infectious disease that has afflicted mankind for centuries, but a recent increase in worldwide incidence has been evidenced. The authors describe a patient with typical lesions of secondary syphilis and moth-eaten alopecia, whose dermoscopic examination demonstrated empty hair follicles, vellus hair, follicular hyperkeratosis, peripheral black dots, dilated and tortuous vessels, reddish brown background, and hypopigmentation of the hair shafts. Furthermore, this case presented an erythematous background more evident than previously described cases. Read More

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http://dx.doi.org/10.1016/j.abd.2020.01.007DOI Listing

Ischemia-modified albumin as a possible marker of oxidative stress in patients with telogen effluvium.

An Bras Dermatol 2020 May 6. Epub 2020 May 6.

Department of Biochemistry, Ataturk Training and Research Hospital, Ankara, Turkey.

Background: Telogen effluvium is the most common form of non-scarring alopecia characterized by diffuse hair loss. Ischemia-modified albumin is a marker of oxidative stress and inflammation.

Objective: The aim of this study was to compare the levels of ischemia-modified albumin of telogen effluvium patients with healthy controls. Read More

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http://dx.doi.org/10.1016/j.abd.2020.01.005DOI Listing

A Hypohidrotic Ectodermal Dysplasia Arising From a New Mutation in a Yorkshire Terrier Dog.

Top Companion Anim Med 2020 Jun 23;39:100404. Epub 2020 Jan 23.

Graduate Program in Animal Science, School of Life Sciences. Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, Brazil.

Hypohidrotic ectodermal dysplasias (HED) constitute a group of genetic disorders that affect ectodermal derivatives such as sweat glands, sebaceous glands, hair, and teeth. The vast majority of cases of HED are caused by a recessive mutation of the EDA gene located in the X chromosome. In these cases, affected individuals are usually male and have alopecia and hypotrichosis with characteristic distribution, in addition to malformed teeth and fewer than normal. Read More

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http://dx.doi.org/10.1016/j.tcam.2020.100404DOI Listing

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth.

Cells 2020 May 28;9(6). Epub 2020 May 28.

Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam 13494, Korea.

Conventional therapeutic applications of mesenchymal stromal cells (MSCs) focus on cell replacement and differentiation; however, increasing evidence suggests that most of their therapeutic effects are carried out by their various secretions. This study investigated the application of conditioned medium (CM) from human umbilical cord blood-derived MSCs (hUCB-MSCs) to improve hair growth and developed a method to reliably produce this optimized CM. Primed MSC-derived CM (P-CM) with combinations of TGF-β1 and LiCl was optimized by comparing its effects on the cell viability of dermal papilla cells (DPCs). Read More

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http://dx.doi.org/10.3390/cells9061344DOI Listing

First- and third- generation EGFR inhibitors mediate distinct phosphoprotein signalling networks: implications for adverse dermatologic reactions.

Br J Dermatol 2020 Jun 1. Epub 2020 Jun 1.

Department of Anesthesiology, Duke University School of Medicine, Durham, NC, 27701, USA.

Epidermal growth factor receptor (EGFR) inhibitors are used to treat several malignancies but notoriously exert dermatologic toxicities, reducing patient adherence. Despite targeting the same receptor, different EGFR inhibitors exhibit distinct toxicities. Up to 90% of patients on EGFR inhibitors present with a papulopustular rash, with varying severity and frequency depending on the inhibitor. Read More

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http://dx.doi.org/10.1111/bjd.19263DOI Listing

The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta-analysis.

Dermatol Ther 2020 Jun 1:e13741. Epub 2020 Jun 1.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University.

Background: Androgenetic alopecia (AGA) is the most common type of baldness affecting both men and women. Studies investigating combination therapies for AGA reported greater efficacy than monotherapy but without rigorous examination. The authors performed a meta-analysis and systemic review to further verify the evidence. Read More

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http://dx.doi.org/10.1111/dth.13741DOI Listing

Comparative Study between Fractional Carbon Dioxide Laser vs Intralesional Steroid injection in Treatment of Alopecia Areata.

Dermatol Ther 2020 Jun 1. Epub 2020 Jun 1.

Dermatology, Venereology and Andrology Department, Ain Shams University Hospitals, Cairo, Egypt.

Few studies have reported Fractional Carbon Dioxide (FCO2) laser use in treating Alopecia Areata (AA), yet, effectiveness of this therapy has not been comparatively analyzed. To assess efficacy and safety of FCO2 laser in comparison to traditional intralesional corticosteroids injection (ILCs) in treatment of AA. This study included 20 patients with at least 2 patches of AA. Read More

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http://dx.doi.org/10.1111/dth.13742DOI Listing

Pregnancy during the course of Cushing's syndrome: a case report and literature review.

Endocrinol Diabetes Metab Case Rep 2020 Apr 12;2020. Epub 2020 Apr 12.

Division of Endocrinology, Guillermo Almenara Irigoyen National Hospital, Lima, Peru.

Summary: Cushing's syndrome is an endocrine disorder that causes anovulatory infertility secondary to hypercortisolism; therefore, pregnancy rarely occurs during its course. We present the case of a 24-year-old, 16-week pregnant female with a 10-month history of unintentional weight gain, dorsal gibbus, nonpruritic comedones, hirsutism and hair loss. Initial biochemical, hormonal and ultrasound investigations revealed hypokalemia, increased nocturnal cortisolemia and a right adrenal mass. Read More

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http://dx.doi.org/10.1530/EDM-20-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159255PMC

Giving A Face to Chemotherapy-Induced Alopecia: A Feasibility Study on Drawings by Patients.

Asia Pac J Oncol Nurs 2020 Apr-Jun;7(2):218-224. Epub 2020 Mar 30.

Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, Netherlands.

Objective: Individuals with cancer experience the impact of chemotherapy on hair loss in different ways. The aim of this pilot study was to explore patients' experiences of alopecia through patients' drawings.

Methods: Fifteen female patients diagnosed with cancer and treated with chemotherapy were recruited at the oncological day-care unit of a teaching hospital in the Netherlands. Read More

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http://dx.doi.org/10.4103/apjon.apjon_8_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233558PMC

Ocrelizumab-induced alopecia areata-A series of five patients from Ontario, Canada: A case report.

SAGE Open Med Case Rep 2020 6;8:2050313X20919614. Epub 2020 May 6.

Division of Dermatology, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: Ocrelizumab is a humanized monoclonal antibody that targets the CD20 antigen found on B-cells. It is indicated in the treatment of both relapsing-remitting multiple sclerosis and primary progressive multiple sclerosis.

Objective: The aim of this study is to report and describe the characteristics of alopecia areata following treatment with ocrelizumab for multiple sclerosis. Read More

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http://dx.doi.org/10.1177/2050313X20919614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233903PMC

Effective use of oral tofacitinib and phototherapy in a patient with concomitant alopecia areata, vitiligo, and plaque and inverse psoriasis.

Clin Case Rep 2020 May 27;8(5):819-822. Epub 2020 Feb 27.

Department of Dermatology Warren Alpert Medical School Brown University Providence RI USA.

This case presentation suggests that tofacitinib combined with phototherapy may be an effective treatment option for patients with concomitant alopecia areata, vitiligo, and different phenotypes of psoriasis including plaque and inverse psoriasis. Read More

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http://dx.doi.org/10.1002/ccr3.2759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250974PMC

Enhanced Follicular Delivery of Finasteride to Human Scalp Skin Using Heat and Chemical Penetration Enhancers.

Pharm Res 2020 May 31;37(6):112. Epub 2020 May 31.

Centre for Research in Topical Drug Delivery and Toxicology, University of Hertfordshire, College Lane, Hatfield, AL10 9AB, UK.

Purpose: The aim of this work was to evaluate whether improved topical delivery of finasteride, focussed to the hair follicles of human scalp skin could be achieved with application of short durations of heat and use of specific chemical penetration enhancers.

Methods: Franz cell experiments with human scalp skin were performed with a range of chemical penetration enhancers at 32°C and 45°C to simulate normal and heated conditions. Selected chemical penetration enhancers were taken forward for finite dose Franz cell studies which examined the effect of heat produced by a prototype external heating system that supplied either 20 or 30 min of additional heat over both a 24 h and a 1 h time period. Read More

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http://dx.doi.org/10.1007/s11095-020-02822-yDOI Listing

Foreign Body Reaction Due To Intralesional Steroid Injection In Treatment Of Alopecia Areata.

Dermatol Ther 2020 May 31:e13703. Epub 2020 May 31.

Fırat Universty Radiology Department, Elazığ.

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http://dx.doi.org/10.1111/dth.13703DOI Listing

Tofacitinib in the treatment of lichen planopilaris: a retrospective review.

J Am Acad Dermatol 2020 May 28. Epub 2020 May 28.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina.

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http://dx.doi.org/10.1016/j.jaad.2020.05.104DOI Listing

LC-MS bioanalytical method for simultaneous determination of latanoprost and minoxidil in the skin.

J Pharm Biomed Anal 2020 May 20;187:113373. Epub 2020 May 20.

Laboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, 70910-900, Brasília, DF, Brazil. Electronic address:

The association of minoxidil sulphate and latanoprost is currently emerging as a promising strategy for the treatment of androgenic alopecia, which is the most common type of scalp hair loss. In order to support the development of new pharmaceutical products containing such drugs combination, this study proposes a simple and efficient LC-MS bioanalytical method to simultaneously quantify minoxidil sulphate and latanoprost in different skin layers. Compounds separation was performed by liquid chromatography using a C column with gradient elution of a mobile phase composed of 0. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113373DOI Listing

A randomized, single-blinded, vehicle-controlled study of a topical active blend in the treatment of androgenetic alopecia.

Dermatol Ther 2020 May 30:e13734. Epub 2020 May 30.

Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, "Attikon" General University Hospital, Athens, Greece.

Introduction: Αndrogenetic alopecia (AGA) is the most common hair disorder, affecting approximately 50% of men and women. A topical lotion that contains two patented formulas (Redensyl® and Sepicontrol A5®), has been introduced as an alternative approach to standard therapies for AGA.

Methods: Forty-four patients with AGA were randomized either to apply the active lotion or the vehicle, twice daily for 24 weeks. Read More

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http://dx.doi.org/10.1111/dth.13734DOI Listing

Interferon-gamma (IFN-γ) Serum Level and Immunohistochemical expression of CD8 cells in tissue biopsies in patients with Alopecia areata in correlation with the trichoscopic findings.

Dermatol Ther 2020 May 29:e13718. Epub 2020 May 29.

Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University.

Alopecia areata is an autoimmune form of non-scarring hair loss Aim: to assess the serum concentration of IFN-γ and CD8 cell expression in lesional skin biopsies in correlation with the disease severity, activity, duration and trichoscopic findings in patients with alopecia areata.

Patients And Methods: the study included 30 patients with AA and 15 age and sex matched healthy controls. Trichoscopy was performed and Photographs were captured for the alopecic areas, ELIZA technique was used for serum level of interferon-gamma assessment and immunohistochemiistry for CD8 cells. Read More

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http://dx.doi.org/10.1111/dth.13718DOI Listing

Safety and efficacy of CDX-014, an antibody-drug conjugate directed against T cell immunoglobulin mucin-1 in advanced renal cell carcinoma.

Invest New Drugs 2020 May 29. Epub 2020 May 29.

Dana-Farber Cancer Institute, Lank Center for Genitourinary Oncology, Boston, MA, USA.

CDX-014 is an antibody-drug conjugate directed against TIM-1, a surface marker highly expressed in renal cell carcinoma (RCC) and ovarian carcinoma. This phase I, first-in-human trial was conducted to evaluate the safety and preliminary activity of CDX-014 in patients with advanced refractory RCC, following a dose-escalation and dose expansion design. CDX-014 was administered intravenously at doses ranging from 0. Read More

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http://dx.doi.org/10.1007/s10637-020-00945-yDOI Listing

Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep.

Cell Death Dis 2020 May 29;11(5):407. Epub 2020 May 29.

Beijing Key Laboratory of Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.

Fibroblast growth factor 5 (FGF5) is a famous dominant inhibitor of anagen phase of hair cycle. Mutations of FGF5 gene result in a longer wool in mice, donkeys, dogs, cats, and even in human eyelashes. Sheep is an important source of wool production. Read More

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http://dx.doi.org/10.1038/s41419-020-2622-xDOI Listing

Association between major depressive disorder and subsequent autoimmune skin diseases: A nationwide population-based cohort study.

J Affect Disord 2020 May 25;274:334-338. Epub 2020 May 25.

School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:

Background: Major depressive disorder (MDD) has been implicated as a risk factor for various immune-related disorders; however, the association between MDD and subsequent autoimmune skin diseases (ASDs) remains unclear. This study aimed to investigate the association of MDD with risk of subsequent ASDs.

Methods: Subjects were recruited from the National Health Insurance Research Database in Taiwan. Read More

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http://dx.doi.org/10.1016/j.jad.2020.05.070DOI Listing

Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use.

Yonsei Med J 2020 Jun;61(6):553-555

Department of Neurology, Gangnam Severance Hospital, Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Korea.

Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults with known risk factors of prothrombotic conditions, pregnancy, infection, malignancy, and drugs. Dutasteride is a 5α-reductase inhibitor that is used for benign prostate hypertrophy and androgenetic alopecia. To date, CVT caused by dutasteride use has not been reported. Read More

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http://dx.doi.org/10.3349/ymj.2020.61.6.553DOI Listing

Expression of CD117 and platelet-derived growth factor receptor α in patients with alopecia areata.

Indian J Dermatol Venereol Leprol 2020 May 27. Epub 2020 May 27.

Department of Pathology, Indira Gandhi Medical College and Research Institute, Puducherry, India.

Background: Alopecia areata is a disease of uncertain, probably autoimmune etiology. The role of growth factors like platelet-derived growth factor and C-kit (CD117) in alopecia areata is unknown.

Aims: To compare the expression of CD117 and platelet-derived growth factor receptor α in tissue samples of alopecia areata and normal controls. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_557_19DOI Listing

Review of the Use of Platelet-Rich Plasma in the Treatment of Alopecia.

Authors:

Plast Surg Nurs 2020 Apr/Jun;40(2):E5

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http://dx.doi.org/10.1097/PSN.0000000000000318DOI Listing

Review of the Use of Platelet-Rich Plasma in the Treatment of Alopecia.

Authors:
Emma Coleman

Plast Surg Nurs 2020 Apr/Jun;40(2):68-72

Emma Coleman, RGN, is the founder of the Emma Coleman Skin Clinics, Kent, England.

Platelet-rich plasma (PRP) therapy is a new approach in dermatology and there is evidence to suggest that it provides excellent adjuvant treatment for nonscarring alopecia cases. There is evidence supporting the hypothesis that PRP therapy increases hair growth and thickness in patients with nonscarring alopecia. Studies including participants with scarring alopecia are limited and larger scale studies with tighter controls in PRP preparation, administration, and follow-up are needed to determine whether this is a clinically sound approach. Read More

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http://dx.doi.org/10.1097/PSN.0000000000000299DOI Listing

Comment on "Azathioprine in combination with methotrexate: a therapeutic alternative in severe and recalcitrant forms of alopecia areata?"

J Eur Acad Dermatol Venereol 2020 May 27. Epub 2020 May 27.

Department of Dermatology, Venereology & Leprology, All India Institute of Medical Sciences, Jodhpur, 342005, India.

We went through the article with great interest and we appreciate the innovative effort of the authors. Authors found that a combination of methotrexate (MTX) and azathioprine (AZA) showed encouraging results in a series of patients with severe, recalcitrant and cosmetically unacceptable multiple alopecia areata (AA) and alopecia totalis (AT). They proposed that this combination immunosuppressive therapy could be justified since the pathogenesis of AA is based on immunological disturbances in skin. Read More

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http://dx.doi.org/10.1111/jdv.16675DOI Listing

Recalcitrant lichen planopilaris and frontal fibrosing alopecia responding to tildrakizumab.

Dermatol Ther 2020 May 26:e13694. Epub 2020 May 26.

Sinclair Dermatology, 2 Wellington Parade, East Melbourne, VIC, Australia.

Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocytic, cicatricial alopecias. Clinically, LPP presents with multifocal patchy alopecia, while FFA, considered a variant of LPP, results in hairline recession. Frontal recession in FFA may progress as far as the mid-scalp and infrequently beyond. Read More

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http://dx.doi.org/10.1111/dth.13694DOI Listing

CYP17 gene polymorphic sequence variation is associated with hyperandrogenism in Kashmiri women with polycystic ovarian syndrome.

Gynecol Endocrinol 2020 May 27:1-5. Epub 2020 May 27.

Department of Biochemistry, University of Kashmir, Srinagar, India.

Polycystic ovarian syndrome is a complex reproductive as well as endocrinological disorder characterized by anovulatory dysfunction, androgen excess and polycystic ovarian morphology. Hyperandrogenism is regarded as a cardinal feature of the disease. It is believed that the excess androgens are produced due to abnormality in steroid biosynthesis pathway wherein cytochrome P450, 17α-hydroxylase (CYP17) plays an imperative role. Read More

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http://dx.doi.org/10.1080/09513590.2020.1770724DOI Listing

Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy's Effectiveness.

Diagnostics (Basel) 2020 May 24;10(5). Epub 2020 May 24.

State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, bldg 6, 107076 Moscow, Russia.

Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment's effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I-IV by the Norwood-Hamilton scale, were treated for 4 months with 5% topical minoxidil joints with corrections for trace element and vitamin imbalances. Read More

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http://dx.doi.org/10.3390/diagnostics10050336DOI Listing

Rosemary ( L., syn Spenn.) and Its Topical Applications: A Review.

Plants (Basel) 2020 May 21;9(5). Epub 2020 May 21.

Faculty of Pharmaceutical Sciences, University of Campinas (Unicamp), Campinas 13083-871, Brazil.

Topical application is an important administration route for drugs requiring local action on the skin, thereby avoiding their systemic absorption and adverse side effects. L. (syn. Read More

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http://dx.doi.org/10.3390/plants9050651DOI Listing

A transcriptomic map of murine and human alopecia areata.

JCI Insight 2020 May 26. Epub 2020 May 26.

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, United States of America.

Alopecia areata (AA) is one of the most common autoimmune conditions, presenting initially with loss of hair without other overt skin changes. The unremarkable appearance of the skin surface contrasts with the complex immune activity occurring at the hair follicle. AA pathogenesis is due to the loss of immune privilege of the hair follicle leading to autoimmune attack. Read More

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http://dx.doi.org/10.1172/jci.insight.137424DOI Listing

Thermal Injury in a Patient Using a Scalp Cooling System to Prevent Chemotherapy-Induced Alopecia.

JCO Oncol Pract 2020 May 26:OP2000021. Epub 2020 May 26.

Department of Dermatology, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1200/OP.20.00021DOI Listing

A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats.

Int J Oral Maxillofac Surg 2020 May 22. Epub 2020 May 22.

State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases, and Department of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University, Xi'an, China. Electronic address:

The aim of this study was to investigate the protective effect of hydrogen in a rat model of osteoradionecrosis of the jaw (ORNJ). The rats and bone marrow-derived mesenchymal stem cells (BMSCs) were pre-treated with hydrogen before receiving irradiation (7Gy per fraction, five fractions in total once a day for rats, 4Gy for BMSCs). Reactive oxygen species (ROS) and cell differentiation were measured in the BMSCs. Read More

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http://dx.doi.org/10.1016/j.ijom.2020.04.011DOI Listing

The efficacy and safety of oral low dose naltrexone versus placebo in the patients with lichen planopilaris; a randomized controlled clinical trial.

J Dermatolog Treat 2020 May 23:1-18. Epub 2020 May 23.

Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Lichen planopilaris (LPP) is one of the important causes of cicatricial alopecia. We aimed to evaluate the efficacy and safety of low-dose naltrexone (LDN) in the setting of a clinical trial in patients with LPP. We included patients with LPP between 2018 and 2020. Read More

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http://dx.doi.org/10.1080/09546634.2020.1774488DOI Listing

An IL17RA frameshift variant in a Holstein cattle family with psoriasis-like skin alterations and immunodeficiency.

BMC Genet 2020 May 24;21(1):55. Epub 2020 May 24.

Institute of Animal Breeding and Genetics, Faculty of Agricultural Sciences, Nutritional Sciences and Environmental Management, Justus-Liebig University Giessen, 35390, Giessen, Germany.

Background: Skin lesions and dermatoses in cattle are often associated with infections due to bacteria, fungi or environmental risk factors. Dermatoses with genetic etiology have been described in cattle. Among these rare disorders, there are primary congenital dermatoses that are associated with inherited nutritional deficiencies, such as bovine hereditary zinc deficiency or zinc deficiency-like syndrome. Read More

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http://dx.doi.org/10.1186/s12863-020-00860-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247147PMC

Paradoxical Skin Reaction to Certolizumab, an Overlap of Pyoderma Gangrenosum and Psoriasis in a Young Woman Treated for Ankylosing Spondylitis: Case Report with Literature Review.

Dermatol Ther (Heidelb) 2020 May 23. Epub 2020 May 23.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wrocław, Poland.

Introduction: Biologic agents form an indispensable part of modern therapeutic regimens for the treatment of severe inflammatory diseases, especially in the fields of rheumatology, dermatology and gastroenterology. They are favoured by both physicians and patients due to their high effectiveness, good patient tolerance and safety. However, interference in the regulation and dynamics of inflammatory cytokines can on occasion lead to an onset of a dermatological condition also known as paradoxical skin reaction. Read More

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http://dx.doi.org/10.1007/s13555-020-00398-4DOI Listing

Spironolactone use does not increase the risk of female breast cancer recurrence: A retrospective analysis.

J Am Acad Dermatol 2020 May 21. Epub 2020 May 21.

Department of Dermatology, The George Washington School of Medicine and Health Sciences, Washington, DC. Electronic address:

Background: Spironolactone is used off-label for androgenic alopecia because of its ability to arrest hair loss progression and long-term safety profile. However, little is known about the safety of spironolactone in breast cancer (BC) survivors. Due to spironolactone's estrogenic effects, there is a theoretical risk for BC recurrence. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.081DOI Listing

Genetically confirmed CARASIL: A case report with a novel HTRA1 mutation and literature review.

World Neurosurg 2020 May 20. Epub 2020 May 20.

Department of Neurology, The Affiliated Hefei Hospital of Anhui Medical University, Hefei, Anhui 230011 P.R. China. Electronic address:

Background: Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is an extremely rare monogenic autosomal disease associated with the HtrA serine protease 1 (HTRA 1) gene mutation. Recently, a few genetically confirmed CARASIL cases with novel HTRA 1 mutations have been reported in countries other than Japan.

Case Description: Here, we report a case of a patient presenting with worsening right hemiplegia and hemiparesthesia. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.128DOI Listing

Different freezing time of superficial liquid nitrogen cryotherapy in treatment of recalcitrant alopecia areata: Randomized clinical trial.

Dermatol Ther 2020 May 22:e13640. Epub 2020 May 22.

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assiut University, Asyut, Egypt.

Recalcitrant alopecia areata is not uncommon in clinical practice and some patients experienced either treatment failure or recurrence with most of the conventional therapies. Several studies have evaluated the efficacy of cryotherapy in the treatment of alopecia areata with controversial results. This study aimed to optimize the ideal timing of liquid nitrogen cryospraying to achieve the most favorable results. Read More

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http://dx.doi.org/10.1111/dth.13640DOI Listing

An atypical presentation of alopecia in discoid lupus erythematosus.

J Cutan Pathol 2020 May 22. Epub 2020 May 22.

Department of Dermatology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.

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http://dx.doi.org/10.1111/cup.13758DOI Listing

Mixed-pattern syphilitic alopecia of the scalp associated with uveitis and asymptomatic neurosyphilis.

J Dermatol 2020 May 22. Epub 2020 May 22.

Departments of, Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1111/1346-8138.15405DOI Listing

A comparison of the efficacy and tolerability of three corticosteroid treatment regimens in patients with alopecia areata.

J Dermatolog Treat 2020 May 22:1-21. Epub 2020 May 22.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Topical corticosteroids (TC) and/or intralesional corticosteroids (IC) are considered first-line treatments for patch-type alopecia areata (AA). However, the efficacies of TC monotherapy, IC monotherapy, and combined topical and intralesional corticosteroids (CC) in patients with AA have never been compared. To evaluate and compare the efficacy and tolerability of 3 corticosteroid treatments (TC, IC, and CC) in patients with AA. Read More

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http://dx.doi.org/10.1080/09546634.2020.1773384DOI Listing

Biotinidase Deficiency: Prevalence, Impact And Management Strategies.

Pediatric Health Med Ther 2020 4;11:127-133. Epub 2020 May 4.

Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey.

Biotinidase deficiency is an autosomal recessive inherited neurocutaneous disorder. Clinically untreated patients with BD can present with variable neurological and dermatological signs, such as seizures, hypotonia, feeding problems, developmental delay, hearing loss, optic atrophy ataxia, alopecia, and skin rash. Clinical findings of patients with partial BD reported in the literature show that it can occur from infancy to adulthood. Read More

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http://dx.doi.org/10.2147/PHMT.S198656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211084PMC

Current advances in stem cell-based therapies for hair regeneration.

Eur J Pharmacol 2020 May 18:173197. Epub 2020 May 18.

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, PR China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, PR China; Jiangsu Engineering Research Center for New-Type External and Transdermal Preparations, PR China. Electronic address:

Alopecia is resulted from various factors that can decrease the regeneration capability of hair follicles and affect hair cycles. This process can be devastating physically and psychologically. Nevertheless, the available treatment strategies are limited, and the therapeutic outcomes are not satisfactory. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173197DOI Listing