1,811 results match your criteria Androgenetic Alopecia


Evaluation of long-term efficacy of finasteride in Korean men with androgenetic alopecia using the basic and specific classification system.

J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea.

Finasteride 1 mg is considered to be the standard treatment method for male androgenetic alopecia (AGA). However, there have only been a few studies investigating its long-term efficacy. Moreover, its effect on various types of AGA remains unknown. Read More

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December 2018

The differentiation potency of trophoblast stem cells from mouse androgenetic embryos.

Stem Cells Dev 2018 Dec 10. Epub 2018 Dec 10.

Tokyo University of Agriculture, 13126, Bioscience , 1-1-1 Sakuragaoka , Setagaya-ku , Tokyo, Japan , 1568502 ;

In mice, trophoblast stem (TS) cells are derived from the polar trophectoderm (TE) of blastocysts. TS cells cultured in the presence of fibroblast growth factor 4 (Fgf4) are in an undifferentiated state and express undifferentiated marker genes such as Cdx2. After removing Fgf4 from the culture medium, TS cells drastically reduce the expression of undifferentiated marker genes, stop cell proliferation and differentiate into all trophoblast cell subtypes. Read More

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December 2018

The relation between androgenetic thin hair diagnosed by trichoscope and benign prostatic hyperplasia.

J Cosmet Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Faculty of Medicine, Benha University, Benha, Egypt.

Background: Androgenetic alopecia carries a major cosmetic disfigurement and benign prostatic hyperplasia is associated with many urinary tract symptoms and both diseases are mediated by dihydrotestosterone.

Objectives: The study aimed to determine the relationship between hair diameter in androgenetic alopecia diagnosed, by trichoscope, to benign prostatic hyperplasia symptoms and signs.

Methods: Fifty androgenetic alopecia males and 50 normal males as control were included. Read More

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December 2018
1 Read

Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis.

Arch Pathol Lab Med 2018 Dec;142(12):1485-1502

From the Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.

Context.—: Distinction of hydatidiform moles from nonmolar specimens and subclassification of hydatidiform moles as complete hydatidiform mole versus partial hydatidiform mole are important for clinical practice and investigational studies. Risk of persistent gestational trophoblastic disease and clinical management differ for these entities. Read More

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December 2018
2 Reads

Acne development in male androgenetic alopecia.

Clin Exp Dermatol 2018 Nov 29. Epub 2018 Nov 29.

Division of Dermatology, University of California Los Angeles David Geffen School of Medicine, 200 Medical Plaza Suite 465, Los Angeles, CA, USA.

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November 2018

Familial frontal fibrosing alopecia: A cross-sectional study of 20 cases from nine families.

Australas J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Servicio de Dermatología, Hospital Universitario Virgen de las Nieves, Granada, Spain.

Background/objectives: Frontal fibrosing alopecia (FFA) is a scarring alopecia whose prevalence is increasing. The pathogenesis of this disease is not well known. Genetic, environmental, hormonal and autoimmunity related factors have been considered; however, only a few cases of familial frontal fibrosing alopecia have been reported. Read More

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November 2018
3 Reads

Use of Minoxidil Sulfate versus Minoxidil Base in Androgenetic Alopecia Treatment: Friend or Foe?

Skin Appendage Disord 2018 Oct 5;4(4):349-350. Epub 2018 Apr 5.

Dermatology Department, São Paulo State University - UNESP, Botucatu, Brazil.

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October 2018
2 Reads

Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq.

Skin Appendage Disord 2018 Oct 7;4(4):268-273. Epub 2017 Dec 7.

Centro de Investigación y Desarrollo en Ciencias de la Salud, UANL, Mexico.

Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. Read More

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October 2018
7 Reads

HrQoL in hair loss-affected patients with alopecia areata, androgenetic alopecia and telogen effluvium: the role of personality traits and psychosocial anxiety.

J Eur Acad Dermatol Venereol 2018 Nov 5. Epub 2018 Nov 5.

Department of Experimental, Diagnostic and Speciality Medicine (DIMES), Alma Mater Studiorum Università di Bologna, Bologna, Italy.

Background: Illness impact on HrQoL has been widely studied in hair loss-affected patients, yet no study has addressed whether individual differences modulate HrQoL in patients with alopecia areata (AA), androgenetic alopecia (AGA) and telogen effluvium (TE).

Objective: To identify the personality dimensions most predictive of the impact of disease on HrQoL.

Method: A single-site cross-sectional study was carried out in the Dermatology Unit of Sant'Orsola-Malpighi Hospital, Bologna between September 2016 and September 2017. Read More

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November 2018
3 Reads

Efficacy of platelet-rich plasma in androgenetic alopecia patients.

J Cosmet Dermatol 2018 Nov 4. Epub 2018 Nov 4.

Department of Biomedical Sciences, Tissue Engineering and Regenerative Medicine Laboratory, King Edward Medical University, Lahore, Pakistan.

Background: Androgenetic alopecia (AGA), a patterned hair loss in both males and females, is a commonly occurring disease worldwide. Conventionally, no curative or satisfactory treatment is available for this condition. Therefore, in the current study, we aim to use platelet-rich plasma (PRP) as an alternative treatment option for the AGA patients. Read More

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November 2018
4 Reads

Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles.

Am J Hum Genet 2018 Nov;103(5):740-751

Department of Human Genetics, McGill University Health Centre, Montréal, QC H4A 3J1, Canada; Department of Obstetrics and Gynecology, McGill University Health Centre, Montréal, QC H4A 3J1, Canada. Electronic address:

Androgenetic complete hydatidiform moles are human pregnancies with no embryos and affect 1 in every 1,400 pregnancies. They have mostly androgenetic monospermic genomes with all the chromosomes originating from a haploid sperm and no maternal chromosomes. Androgenetic complete hydatidiform moles were described in 1977, but how they occur has remained an open question. Read More

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November 2018
1 Read

Impact on Quality of Life in Patients who came with Androgenetic Alopecia for Hair Transplantion Surgery in a Clinic.

JNMA J Nepal Med Assoc 2018 Jul-Aug;56(212):763-765

Department of Dermatology, Kathmandu Medical College, Sinamangal, Kathmandu, Nepal.

Introduction: Androgenetic alopecia, also known as as male pattern baldness, affects up to 50% of men and 10% females worldwide. Patients with baldness seem to have a great impact on quality of life including their self-esteem, confidence, relationship as well as work.

Methods: This is a cross-sectional descriptive study on dermatology quality of life index in patients with androgenetic alopecia who came for hair transplantation surgery at Aavaran Skin Clinic Pvt Ltd, Battisputali, Kathmandu between 15th July 2017 to 15th February 2018. Read More

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November 2018
1 Read

A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l-carnitine to prevent and treat hair loss: A prospective investigation.

Dermatol Ther 2018 Oct 29:e12778. Epub 2018 Oct 29.

Fidia Farmaceutici s.p.a., Abano Terme, Italy.

Hair loss is a common aesthetic disorder that can be triggered by genetic, inflammatory, hormonal, and environmental factors acting on hair follicles and their life cycle. There are several types of hair loss that differ in causes, symptoms, and spatial and temporal progression. Androgenic alopecia, a common form of hair loss, is the consequence of a decreased microcirculation of the scalp as well as the toxic action of elevated dihydrotestosterone levels on the hair bulbs. Read More

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October 2018

Gestational Trophoblastic Neoplasia From Genetically Confirmed Hydatidiform Moles: Prospective Observational Cohort Study.

Int J Gynecol Cancer 2018 Nov;28(9):1772-1780

Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Objective: The aim of this study was to evaluate the incidence and risk factors of gestational trophoblastic neoplasia (GTN) from hydatidiform moles (HMs) cytogenetically diagnosed in a prospective cohort setting.

Methods: The prospective observational cohort study included cases of cytogenetically defined molar pregnancies, which were diagnosed by a multiplex short tandem repeat polymorphism analysis. Cases were classified as androgenetic complete HMs (CHMs), diandric monogynic triploid partial HMs (PHMs), or biparental abortion. Read More

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November 2018
1 Read

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi.

J Vis Exp 2018 Oct 5(140). Epub 2018 Oct 5.

Center for Bioscience Research and Education, Utsunomiya University;

The genetic and molecular components of the sex-determination cascade have been extensively studied in the honeybee, Apis mellifera, a hymenopteran model organism. However, little is known about the sex-determination mechanisms found in other non-model hymenopteran taxa, such as ants. Because of the complex nature of the life cycles that have evolved in hymenopteran species, it is difficult to maintain and conduct experimental crosses between these organisms in the laboratory. Read More

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October 2018

Bold to do - bald to be? Outcomes decades after harvesting the scalp in burned children.

Burns 2018 Oct 15. Epub 2018 Oct 15.

Pediatric Burn Center, Division of Plastic and Reconstructive Surgery, Department of Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8700 Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Steinwiesstrasse 75, 8700 Zurich, Switzerland.

Background: The scalp is the only hidden donor site for split thickness skin grafts. Nevertheless, it is underappreciated due to fear of iatrogenic scarring alopecia. Long-term data showing whether androgenetic hair loss can reveal previously hidden scarring alopecia is unavailable. Read More

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October 2018
7 Reads

Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons.

Authors:
Gordon H Sasaki

Aesthetic Plast Surg 2018 Oct 15. Epub 2018 Oct 15.

Loma Linda Medical University, Loma Linda, CA, USA.

Plastic surgeons are frequently asked to manage male- and female-pattern hair loss in their practice. This article discusses the epidemiology, pathophysiology, and current management of androgenetic alopecia and emphasizes more recent knowledge of stem cell niches in hair follicles that drive hair cycling, alopecia, and its treatment. The many treatment programs available for hair loss include newer strategies that involve the usage of growth factors, platelet-rich plasma, and fat to stimulate follicle growth. Read More

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October 2018
13 Reads

Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions.

Cell Stem Cell 2018 Nov 11;23(5):665-676.e4. Epub 2018 Oct 11.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; University of the Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Unisexual reproduction is widespread among lower vertebrates, but not in mammals. Deletion of the H19 imprinted region in immature oocytes produced bimaternal mice with defective growth; however, bipaternal reproduction has not been previously achieved in mammals. We found that cultured parthenogenetic and androgenetic haploid embryonic stem cells (haESCs) display DNA hypomethylation resembling that of primordial germ cells. Read More

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November 2018
8 Reads

Androgens in Women: Hormone modulating therapies for skin disease (Part II).

J Am Acad Dermatol 2018 Oct 9. Epub 2018 Oct 9.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine. Electronic address:

Androgen-mediated cutaneous disorders (AMCDs) in women including acne, hirsutism, and female pattern hair loss (FPHL) can be treated with hormone-modulating therapies. In the second part of this Continuing Medical Education series, we discuss the hormone-modulating therapies available to dermatologists for the treatment of AMCDs including combined oral contraceptives, spironolactone, finasteride, dutasteride, and flutamide. Available hormone-modulating treatments utilized for each AMCDs are reviewed, along with mechanisms of androgen modulation, safety profile, contraindications, monitoring parameters, and evidence of efficacy. Read More

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October 2018
1 Read

Androgens in Women: Androgen mediated skin disease and patient evaluation (Part I).

J Am Acad Dermatol 2018 Oct 9. Epub 2018 Oct 9.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine. Electronic address:

Androgens are produced throughout the body in steroid-producing organs, such as the adrenal glands and ovaries, as well as in other tissues, like the skin. Several androgens are found normally in women, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), testosterone, dihydrotestosterone (DHT), and androstenedione. These androgens are essential in the development of several common cutaneous conditions in women, including acne, hirsutism, and female pattern hair loss (FPHL) - androgen mediated cutaneous disorders (AMCDs). Read More

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October 2018
2 Reads

Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Nonscarring Alopecia.

Med Arch 2018 Apr;72(2):136-140

Biota Laboratories, R&D Center, Sancaktepe, Istanbul, Turkey.

Background: Currently while, topical minoxidil and oral finasteride are the only medications approved in androgenetic alopecia (AGA), the cause oriented treatment and immunsupressive treatment are being performed in telogen effluvium (TE) and alopecia areata (AA) respectively. Considering the inflammatory factors in the pathogenesis of these three nonscarring alopecia forms, we have formulated a mixture for topical usage composed of six different herbal extracts (HE) which have already known antiinflammatory and antioxidant features.

Materials And Methods: In addition to performing the phytochemical analysis of HE, we detected the gene expression level of IL-1α, the crucial hair loss mediator, for the putative efficacy in nonscarring alopecia. Read More

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April 2018
2 Reads

The rise of transcutaneous drug delivery for the management of alopecia: A review of existing literature and an eye towards the future.

J Cosmet Laser Ther 2018 Oct 9:1-8. Epub 2018 Oct 9.

a Department of Dermatology , University of Minnesota , Minneapolis , Minnesota , United States.

Introduction: Fractional lasers and microneedling devices are increasingly used with topical drugs to treat various conditions, including alopecia, as they grant access to dermal structures such as hair follicles and cutaneous vasculature.

Objective: To perform a comprehensive review on transcutaneous drug delivery for the management of alopecia.

Methods: PubMed, Embase, and Ovid Medline databases were searched using terms including: alopecia, microneedling, lasers, androgenetic alopecia (AGA), alopecia areata (AA), drug delivery. Read More

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October 2018
12 Reads

"Treatment of male pattern alopecia with platelet-rich plasma: a double blind controlled study with analysis of platelet number and growth factor levels".

J Am Acad Dermatol 2018 Oct 1. Epub 2018 Oct 1.

Hemocentro, Hemostasis Laboratory, University of Campinas UNICAMP, Carlos Chagas Street, 480, CEP: 13083-878, Campinas, SP, Brazil.

Background: Promising results were described with platelet-rich plasma (PRP) in androgenetic alopecia that could be associated to platelet number and growth factor levels.

Objective: Analyze the platelet number and growth factor levels in PRP and its correlation with hair growth parameters evaluated by TrichoScan.

Methods: Twenty-six patients randomized to receive four subcutaneous injections of PRP or saline. Read More

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October 2018
2 Reads

Persistent Alopecia in a Breast Cancer Patient Following Taxane Chemotherapy and Adjuvant Endocrine Therapy: Case Report and Review of Post-treatment Hair Loss in Oncology Patients with Breast Cancer.

Cureus 2018 Jul 27;10(7):e3056. Epub 2018 Jul 27.

Dermatologist, San Diego Family Dermatology, San Diego, USA.

Taxane chemotherapy and adjuvant endocrine therapy are commonly used in breast cancer patients following surgery. We describe a 59-year-old woman with a triple-positive invasive right breast cancer that was treated with surgery, radiation, chemotherapy, and adjuvant hormonal therapy. She subsequently developed scalp alopecia, with histopathological features of both androgenetic alopecia and alopecia areata; the hair loss did not resolve after completion of her chemotherapy. Read More

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July 2018
4 Reads

Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition.

Psychoneuroendocrinology 2019 Jan 18;99:206-215. Epub 2018 Sep 18.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy. Electronic address:

Persistent alteration of plasma neuroactive steroid levels associated with major depression has been recently reported in men after the suspension of the treatment for androgenetic alopecia with finasteride, an inhibitor of the enzyme 5alpha-reductase. Observations in male rats confirmed persistent alterations in neuroactive steroid levels also in the brain. In the present study, we have ascertained possible effects on depressive-like behavior, neurogenesis, gliosis, neuroinflammation and gut microbiota in male rats after subchronic treatment for 20 days with finasteride and after one month of its withdrawal. Read More

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January 2019
2 Reads

Telogen hair loss and androgenetic-like alopecia in GAPO syndrome.

Australas J Dermatol 2018 Sep 25. Epub 2018 Sep 25.

Department of Developmental Biology, Harvard School of Dental Medicine and Harvard Medical School, Boston, Massachusetts, USA.

Growth retardation, Alopecia, Pseudoanodontia and Optic atrophy (GAPO) syndrome is a rare autosomal recessive condition whose cardinal features include a recognizable craniofacial dysmorphosis, growth retardation, alopecia, pseudoanodontia, and premature aging. We report on a 2-year-old Pakistani man affected with GAPO syndrome who additionally shows an androgenetic-like alopecia with normal testosterone levels and telogen hair loss. These are novel findings in GAPO syndrome. Read More

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September 2018

Controversies in the treatment of androgenetic alopecia: The history of finasteride.

Dermatol Ther 2018 Sep 25:e12647. Epub 2018 Sep 25.

Department of Dermatology and Venereology, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.

Male androgenetic alopecia (AGA) affects up to 60% of men by the age of 50. Currently, there are only two approved drugs for the treatment of male AGA: topical minoxidil and oral finasteride. Topical minoxidil is readily available over the counter and has a well-established safety record. Read More

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September 2018
3 Reads

Shedding light on the FDA's 510(k) approvals process: low-level laser therapy devices used in the treatment of androgenetic alopecia.

J Dermatolog Treat 2018 Nov 19:1-3. Epub 2018 Nov 19.

b Department of Dermatology, University Hospitals Cleveland Medical Center , Cleveland , OH , USA.

Introduction: Low-level laser therapy has demonstrated superior efficacy relative to other nonsurgical treatment options for the treatment of androgenetic alopecia.

Methods: Records from a public U.S. Read More

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November 2018
5 Reads

Feature characterization of scarring and non-scarring types of alopecia by multiphoton microscopy.

Lasers Surg Med 2018 Sep 24. Epub 2018 Sep 24.

Department of Dermatology, University of California, Irvine, California.

Objectives: Non-invasive visualization of hair follicles is important for proper diagnosis and management of alopecia; however, histological assessment remains the gold standard. Laser imaging technologies have made possible noninvasive in vivo evaluation of skin and hair follicle. The aim of this study was to evaluate the ability of multiphoton microscopy (MPM) to non-invasively identify morphological features that can distinguish scarring from non-scarring alopecia. Read More

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September 2018
2 Reads

Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C's of oral therapy.

Authors:
Renée A Beach

Dermatol Ther 2018 Nov 24;31(6):e12707. Epub 2018 Sep 24.

Division of Dermatology, Department of Medicine, Women's College Hospital, Toronto, Canada.

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November 2018
1 Read

Association of Hair Loss With Health Utility Measurements Before and After Hair Transplant Surgery in Men and Women.

JAMA Facial Plast Surg 2018 Dec;20(6):495-500

Department of Otolaryngology, Massachusetts Eye and Ear, Harvard Medical School, Boston.

Importance: Androgenetic alopecia is a highly prevalent condition across both sexes and can be surgically corrected through hair transplant. Health utility scores, which represent quantitative estimates of individual preferences for a given state of health, are a measure of health-related quality of life. The health utility scores for sex-specific alopecia and the posttransplant state have not previously been quantified. Read More

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December 2018
8 Reads

Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients.

Dermatol Ther 2018 Nov 8;31(6):e12741. Epub 2018 Oct 8.

Applied Biology, Inc., Irvine, California.

Topical minoxidil is the only US FDA approved OTC drug for the treatment of androgenetic alopecia (AGA). Minoxidil is a pro-drug converted into its active form, minoxidil sulfate, by the sulfotransferase enzymes in the outer root sheath of hair follicles. Previously, we demonstrated that sulfotransferase activity in hair follicles predicts response to topical minoxidil in the treatment of AGA. Read More

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November 2018
2 Reads

Transcriptome Analysis of Rainbow Trout () Eggs Subjected to the High Hydrostatic Pressure Treatment.

Int J Genomics 2018 26;2018:5197126. Epub 2018 Aug 26.

Department of Marine Biology and Ecology, Institute of Oceanography, Faculty of Oceanography and Geography, University of Gdansk, M. Piłsudskiego 46 Av, 81-378 Gdynia, Poland.

High hydrostatic pressure (HHP) causes depolymerization of the spindle microtubules. HHP applied to fish eggs prevents extrusion of the second polar body and inhibits the first cell cleavage, and it is used to produce triploids and diploid gynogenetic and androgenetic individuals. HHP has been also found to affect biomolecules including nucleic acids, and it may be presumed that HHP administered to the rainbow trout () eggs disturbs cytoplasmic maternal RNA indispensable for the early embryogenesis. Read More

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Synergistic effect of platelet-rich plasma injections and scalp lifting in androgenetic alopecia.

Clin Dermatol 2018 Sep - Oct;36(5):673-679. Epub 2018 Mar 24.

Department of Medical Research, Research Assistant Center, Show Chwan Memorial Hospital, Changhua, Taiwan. Electronic address:

Androgenetic alopecia (AGA) is a common hair loss disorder, especially in men and the elderly. In this study, we analyzed the therapeutic effects of platelet-rich plasma (PRP) injections and embedded sutures in patients with AGA. In each participant, we administered different treatments in one area of hair loss that was divided into four sections. Read More

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March 2018
1 Read

Platelet-Rich Plasma for Hair Loss: Review of Methods and Results.

Facial Plast Surg Clin North Am 2018 Nov 16;26(4):469-485. Epub 2018 Aug 16.

Spokane Center for Facial Plastic Surgery, 217 West Cataldo Avenue, Spokane, WA 99201, USA; Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA. Electronic address:

Given substantial advances in hair regrowth research and platelet-rich plasma (PRP) science, a review of currently used systems and results is informative for physicians using a biologics approach to hair restoration. Overall positive clinical response to the use of PRP in androgenetic and alopecia areata patients is observed. The effects on hair density, count, and thickness were demonstrated through multiple clinical trials. Read More

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November 2018
12 Reads

Estimation of Zinc and Iron Levels in the Serum and Hair of Women with Androgenetic Alopecia: Case-control Study.

Indian J Dermatol 2018 Sep-Oct;63(5):369-374

Department of Pharmacology and Toxicology, College of Pharmacy, Basra, Iraq.

Background: Although female androgenetic alopecia (FAGA) occurs in genetically susceptible women, some trace elements may play an important role.

Aim Of The Study: This study aimed to evaluate serum and hair zinc and iron levels in patients with FAGA and to compare the findings with normal controls.

Patients And Methods: A case-control study that was conducted at Dermatology Clinic in Basra General Hospital, Basra, Iraq. Read More

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September 2018

Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia.

World J Mens Health 2018 Aug 10. Epub 2018 Aug 10.

Department of Urology, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University Hospital, Jeonju, Korea.

Finasteride is primarily used to treat benign prostatic hyperplasia (BPH) and male androgenetic alopecia (MAA). Five-alpha reductase inhibitors (5α-RIs) could induce male sexual dysfunction due to their effects on testosterone and dihydrotestosterone. There is evidence suggesting that 5α-RIs may independently increase the risk of erectile dysfunction (ED). Read More

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August 2018
1 Read

Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis.

Acta Derm Venereol 2018 Sep 12. Epub 2018 Sep 12.

Department of Dermatology, Institute of Hair and Cosmetic Medicine, Wonju College of Medicine, Yonsei University, 26426 Wonju, Korea.

Treatment of male androgenetic alopecia with 5α-reductase inhibitors is efficacious. However, the risk of adverse sexual effects remains controversial. This systematic review and meta-analysis investigated the risk of adverse sexual effects due to treatment of androgenetic alopecia in male patients with finasteride, 1 mg/day, or dutasteride, 0. Read More

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September 2018

Efficacy and Safety of a Topical Botanical in Female Androgenetic Alopecia: A Randomized, Single-Blinded, Vehicle-Controlled Study.

Skin Appendage Disord 2018 Aug 16;4(3):160-165. Epub 2017 Nov 16.

2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, "Attikon" General University Hospital, Athens, Greece.

Introduction: Androgenetic alopecia (AGA) in females is a difficult to treat skin disorder. A novel topical botanical lotion has been approved for its treatment. It acts by increasing Bcl-2, perifollicular Langerhans and mast cells, and perifollicular collagen. Read More

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August 2018
9 Reads

The new paradigm for androgenetic alopecia and plant-based folk remedies: 5α-reductase inhibition, reversal of secondary microinflammation and improving insulin resistance.

J Ethnopharmacol 2018 Dec 6;227:206-236. Epub 2018 Sep 6.

Department of Chemistry, University of New England, Armidale, NSW 2351, Australia. Electronic address:

Ethnopharmacological Relevance: Research in the past half a century has gradually sketched the biological mechanism leading to androgenetic alopecia (AGA). Until recently the aetiological paradigm has been too limited to enable intelligent commentary on the use of folk remedies to treat or reduce the expression of this condition. However, our understanding is now at a point where we can describe how some folk remedies work, predict how effective they will be or why they fail. Read More

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December 2018
5 Reads

Translation into Portuguese language (Brazil), transcultural adaptation and validation of the quality of life questionnaire in female pattern hair loss (WAA-QoL-BP).

An Bras Dermatol 2018 Sep-Oct;93(5):701-706

Department of Dermatology and Radiotherapy, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu (SP), Brazil.

Background: Female pattern hair loss (FPHL) is a common complaint in adult women and inflicts major impact in quality of life, however, there is no specific questionnaire available in Portuguese for such evaluation.

Objectives: Translation into Brazilian Portuguese, cultural adaptation and validation of the WAA-QoL (Women's Androgenetic Alopecia Quality of Life Questionnaire).

Methods: Methodological study. Read More

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October 2018
3 Reads

Comparison of quality of life in patients with androgenetic alopecia and alopecia areata.

An Bras Dermatol 2018 Sep-Oct;93(5):651-658

Department of Dermatology, University of Istanbul Medeniyet, Istanbul, Turkey.

Background: Androgenetic alopecia is one of the most common forms of hair loss. Alopecia areata is a common autoimmune disorder which causes hair loss. It has been previously reported that both alopecia disorders can have negative effects on quality of life. Read More

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October 2018
2 Reads

Minoxidil in the treatment of androgenetic alopecia.

Dermatol Ther 2018 09 28;31(5):e12686. Epub 2018 Aug 28.

Applied Biology, Inc., Irvine, California.

The National Institutes of Health (US NIH, 2018) estimates that in the US approximately 50 million men and 30 million women suffer from AGA (also known as pattern hair loss). Minoxidil is the only topical drug for the treatment of both female and male pattern hair loss. In the US, minoxidil is approved over-the-counter (OTC) at a maximum concentration of 5%. Read More

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September 2018
13 Reads

Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial.

Dermatol Surg 2018 Sep;44(9):1191-1200

Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.

Background: Studies suggest platelet-rich plasma (PRP) may mitigate androgenetic alopecia (AGA), but each varies in the frequency of and interval between treatments.

Objective: To compare the efficacy, satisfaction, tolerability, and safety of 2 initial PRP injection protocols over 6 months.

Methods: Prospective, randomized, single-blinded trial among 40 patients with moderate AGA. Read More

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September 2018

Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach.

Drug Des Devel Ther 2018 23;12:2259-2265. Epub 2018 Jul 23.

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia,

Introduction: Finasteride (FIN) is known as type II 5α-reductase inhibitor, which has been approved for the treatment and prevention of androgenetic alopecia. Administration of FIN by oral route has led to undesirable systemic side effects that include mood disturbance, gynecomastia, decreased libido, erectile dysfunction, and ejaculation disorder. The aim was to improve FIN delivery through skin layers and hair follicles that could possibly reduce its major side effects resulting from long-term oral administration for the treatment and prevention of male pattern baldness. Read More

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November 2018
8 Reads

Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia.

Dermatol Surg 2018 10;44(10):1295-1303

Department of Pediatrics, Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: A new treatment for androgenetic alopecia (AGA) is a 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth. Read More

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October 2018
8 Reads

Utility of Horizontal Sections of Scalp Biopsies in Differentiating between Androgenetic Alopecia and Alopecia Areata.

Dermatology 2018 9;234(3-4):137-147. Epub 2018 Aug 9.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: Androgenetic alopecia (AGA) and alopecia areata (AA) are common causes of alopecia which can sometimes be difficult to differentiate clinically. Horizontal sections of scalp biopsies are used to study non-cicatricial alopecias due to the ability to perform both quantitative and morphometric analysis of hair follicles on them.

Methods: It was a prospective, cross-sectional study conducted to assess the utility of horizontal sections to differentiate between the alopecias. Read More

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August 2018
5 Reads

Harvested vs estimated follicular units in hair transplantation.

J Cosmet Dermatol 2018 Aug 6. Epub 2018 Aug 6.

Department of Dermatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.

Background: The follicular unit transplantation strip harvesting surgery is one of the gold standard methods of hair transplantation; the counting follicular unit ratio and hair density is a major step in donor site evaluation.

Aims: We conducted the study for analyzing the preoperative donor site evaluation and comparison of the actual harvested and estimated follicular units in hair transplantation.

Patients/methods: In this retrospective study, we enrolled 65 male patients with androgenetic alopecia who underwent follicular unit transplantation. Read More

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August 2018
4 Reads

Biparental/androgenetic mosaicism in a male with features of overgrowth and placental mesenchymal dysplasia.

Clin Genet 2018 Dec 7;94(6):564-568. Epub 2018 Sep 7.

School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri.

Biparental/androgenetic mosaicism is a rarely diagnosed condition in humans. It is typically ascertained prenatally on the basis of placental mesenchymal dysplasia. Fetal outcome can range from demise due to intrauterine growth retardation to term delivery. Read More

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December 2018
12 Reads

Psychological assessment in 355 Chinese college students with androgenetic alopecia.

Medicine (Baltimore) 2018 Aug;97(31):e11315

Department of Gastroenterology, the First Affiliated Hospital of Sun Yat-sen University.

Although the association of the psychological problems and androgenetic alopecia (AGA) gained the increasing attention, the psychosocial state in college students with AGA remains unknown. We recruited a total number of 355 college students with AGA from 18 universities in Southern China for interview. The Symptom Checklist-90-R (SCL-90-R) survey was used to assess the psychological state of these students. Read More

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August 2018
2 Reads