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    20027 results match your criteria Androgenetic Alopecia

    1 OF 401

    Risk of sun-induced skin cancers in patients with alopecia areata, alopecia totalis and alopecia universalis.
    J Eur Acad Dermatol Venereol 2018 Apr 21. Epub 2018 Apr 21.
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH.
    Alopecia areata (AA) is an autoimmune non-scarring hair loss characterized by round patches on the scalp and body. It can progress to alopecia totalis (AT) where there is total loss of scalp hair and alopecia universalis (AU) in where hair loss encompasses the entire body. The pathophysiologic mechanism is unclear, but is thought to be due to peribulbar T-cell inflammation which results in premature induction of anagen follicles to catagen and telogen, without causing destruction of the hair follicle. Read More

    Integrin αvβ6: structure, function and role in health and disease.
    Int J Biochem Cell Biol 2018 Apr 17. Epub 2018 Apr 17.
    Faculty of Dentistry, Department of Oral Biological and Medical Sciences, University of British Columbia, 2199 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada. Electronic address:
    Integrins are cell surface receptors that traditionally mediate cell-to-extracellular matrix and cell-to-cell adhesion. They can, however, also bind a large repertoire of other molecules. Integrin αvβ6 is exclusively expressed in epithelial cells where it can, for example, serve as a fibronectin receptor. Read More

    [Dermatologic toxicities of immune checkpoint inhibitors].
    Ann Dermatol Venereol 2018 Apr 17. Epub 2018 Apr 17.
    Oncodermatologie, institut universitaire du cancer Toulouse Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
    The development of immune checkpoint inhibitors (monoclonal antibodies targeting PD-1/PD-L1 or CTLA-4) represents a significant advance in the treatment of multiple cancers. Given their particular mechanism of action, which involves triggering CD4+/CD8+ T-cell activation and proliferation, they are associated with a specific safety profile. Their adverse events are primarily immune-related, and can affect practically all organs. Read More

    The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms.
    J Dermatol Sci 2018 Apr 11. Epub 2018 Apr 11.
    Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Human Environment Interface Biology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Background: Cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, increases the intracellular level of cyclic adenosine monophosphate to cause vasodilation. Topical application of cilostazol is reported to improve local blood flow and enhance wound healing; however, its effect on human hair follicles is unknown.

    Objective: The purpose of this study was to determine the effect of cilostazol on hair growth. Read More

    Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?
    Endocrine 2018 Apr 19. Epub 2018 Apr 19.
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy.
    Sexual dysfunction is a clinical condition due to different causes including the iatrogenic origin. For instance, it is well known that sexual dysfunction may occur in patients treated with antidepressants like selective serotonin reuptake inhibitors (SSRI). A similar side effect has been also reported during treatment with finasteride, an inhibitor of the enzyme 5alpha-reductase, for androgenetic alopecia. Read More

    Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology.
    J Am Acad Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    University of California, Irvine, Department of Dermatology, Irvine, CA, 92697.
    Background: Janus kinase inhibitors (JAKi) have attracted attention for their role in treating inflammatory disorders. This new class of biologics has the potential to significantly impact the field of dermatology, especially with the development of topical formulations.

    Objective: To summarize published evidence on the efficacy, safety, and tolerability of topical JAKi in the treatment of inflammatory skin conditions. Read More

    Taking advantage from phenotype variability in a local animal genetic resource: identification of genomic regions associated with the hairless phenotype in Casertana pigs.
    Anim Genet 2018 Apr 19. Epub 2018 Apr 19.
    Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy.
    Casertana is an endangered autochthonous pig breed (raised in south-central Italy) that is considered to be the descendant of the influential Neapolitan pig population that was used to improve British breeds in the 19th century. Casertana pigs are characterized by a typical, almost complete, hairless phenotype, even though a few Casertana pigs are normal haired. In this work, using Illumina PorcineSNP60 BeadChip data, we carried out a genome-wide association study and an F analysis with this breed by comparing animals showing the classical hairless phenotype (n = 81) versus pigs classified as haired (n = 15). Read More

    Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology.
    Genet Res Int 2018 18;2018:7624932. Epub 2018 Feb 18.
    Department of Molecular Endocrinology, National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai 400012, India.
    Polycystic ovary syndrome is a multifactorial endocrine disorder whose pathophysiology baffles many researchers till today. This syndrome is typically characterized by anovulatory cycles and infertility, altered gonadotropin levels, obesity, and bulky multifollicular ovaries on ultrasound. Hyperandrogenism and insulin resistance are hallmark features of its complex pathophysiology. Read More

    Traction alopecia: the root of the problem.
    Clin Cosmet Investig Dermatol 2018 6;11:149-159. Epub 2018 Apr 6.
    Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL, USA.
    Traction alopecia (TA) affects one-third of women of African descent who wear various forms of traumatic hairstyling for a prolonged period of time. The risk of TA is increased by the extent of pulling and duration of traction, as well as the use of chemical relaxation. The frequent use of tight buns or ponytails, the attachment of weaves or hair extensions, and tight braids (such as cornrows and dreadlocks) are believed to be the highest risk hairstyles. Read More

    Prospective randomized study of sexual function in men taking dutasteride for the treatment of androgenetic alopecia.
    J Dermatol 2018 Apr 18. Epub 2018 Apr 18.
    GSK, Brentford, Middlesex, UK.
    Treatment with 5α-reductase inhibitors has been associated with sexual adverse events such as impotence (erectile dysfunction) and decreased libido. The primary objective of this study was to evaluate adverse events related to sexual function, based on their frequency, duration, persistence and associated treatment discontinuations, in men treated with dutasteride for androgenetic alopecia. Participants were randomized to receive double-blind dutasteride 0. Read More

    Two phase I, pharmacokinetic, and pharmacodynamic studies of DFP-10917, a novel nucleoside analog with 14-day and 7-day continuous infusion schedules.
    Invest New Drugs 2018 Apr 18. Epub 2018 Apr 18.
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
    Purpose DFP-10917 is a novel deoxycytidine analog with a unique mechanism of action. Brief exposure to high concentrations of DFP-10917 inhibits DNA polymerase resulting in S-phase arrest, while prolonged exposure to DFP-10917 at low concentration causes DNA fragmentation, G2/M-phase arrest, and apoptosis. DFP-10917 demonstrated activity in tumor xenografts resistant to other deoxycytidine analogs. Read More

    Congenital Hydrocephalus: Gómez-López-Hernández syndrome. An underdiagnosed Syndrome. A clinical case.
    Rev Chil Pediatr 2018 Feb;89(1):92-97
    División de Pediatría, Unidad de Neurología Pediátrica, Chile,
    Introduction: Hydrocephalus is defined as complex conditions influenced by genetic and environmental factors. Excluding hydrocephalus acquired from infection or brain tumors, congenital hydrocephalus with a genetic cause may occur isolated (hydrocephalus isolated, pure or non-syndromatic) or as a component of a genetic syndrome (syndromic hydrocephalus).

    Objective: To present a syndromic congenital hydrocephalus with a known diagnosis, in order to be considered in the study of this pathology and to perform a review of hydrocephaly with a genetic cause. Read More

    Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases.
    Trends Mol Med 2018 Apr 13. Epub 2018 Apr 13.
    Centre for Dermatology Research, University of Manchester, MAHSC and NIHR Manchester Biomedical Research Centre, Manchester, UK; Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:
    Inflammation-associated, irreversible damage to epithelial stem cells (eSCs) of the hair follicle in their immunologically privileged niche lies at the heart of scarring alopecia, which causes permanent difficult-to-treat hair loss. We propose that the two most common and closely related forms, lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA), provide excellent model diseases for studying the biology and pathology of adult human eSCs in an easily accessible human mini-organ. Emphasising the critical roles for interferon (IFN)-γ and peroxisome proliferator-activated receptor (PPAR)-γ-mediated signalling in immune privilege (IP) collapse and epithelial-mesenchymal transition (EMT) of these eSCs respectively, we argue that these pathways deserve therapeutic targeting in the future management of LPP/FFA and other eSC diseases associated with IP collapse and EMT. Read More

    Lymphocytic Mural Folliculitis Resembling Epitheliotropic Lymphoma in Tigers ( Panthera tigris).
    Vet Pathol 2018 Jan 1:300985818766213. Epub 2018 Jan 1.
    2 Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
    A striking form of lymphocytic mural folliculitis is described in 6 tigers ( Panthera tigris). Clinically, all tigers exhibited regionally extensive chronic, variably waxing and waning alopecia with minimal scaling and crusting most pronounced over the head, neck, and shoulders. More severely affected tigers exhibited marked hyperpigmentation and lichenification. Read More

    Scalp cooling successfully prevents alopecia in breast cancer patients undergoing anthracycline/taxane-based chemotherapy.
    Breast 2018 Apr 13;40:1-3. Epub 2018 Apr 13.
    Berlin Oncology Center Kurfürstendamm, Kurfürstendamm 216, 10179 Berlin, Germany.
    Introduction: Chemotherapy for breast cancer induces alopecia, representing a major source of patient distress. This study assesses whether a scalp-cooling device is effective in reducing chemotherapy-induced alopecia, and assesses adverse treatment effects.

    Materials And Methods: A prospective observational study including women with breast cancer undergoing chemotherapy and scalp cooling using a Paxman device. Read More

    CME Part 2: Hair disorders in cancer survivors Persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, and hair growth disorders related to endocrine therapy or cancer surgery.
    J Am Acad Dermatol 2018 Apr 13. Epub 2018 Apr 13.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:
    With increasing survival rates across all cancers, survivors represent a growing population that is frequently affected by persistent or permanent hair growth disorders as a result of systemic therapies, radiotherapy, surgical procedures, and therapeutic transplants. These hair disorders include persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, endocrine therapy-induced alopecia and hirsutism, post-surgery alopecia and localized hypertrichosis, alopecia attributed to therapeutic transplants, and to novel anticancer therapies. The information contained in this continuing medical education article should facilitate a better understanding on hair disorders in cancer survivors, so that adequate support and therapies may be provided to cancer survivors. Read More

    CME Part 1: Hair disorders in cancer patients.
    J Am Acad Dermatol 2018 Apr 13. Epub 2018 Apr 13.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:
    Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders (including alopecia, hirsutism, hypertrichosis, pigmentary and textural hair changes). The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy -induced alopecia has been well-documented mainly in the oncology literature, however the effect of other alterations such as radiation-induced alopecia, hirsutism, changes in hair color or texture on quality of life have not been described. Read More

    A Proposed Mechanism for Central Centrifugal Cicatricial Alopecia.
    Exp Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    Wake Forest University, Department of Dermatology, Winston-Salem, NC, USA.
    Central centrifugal cicatricial alopecia (CCCA) has an unknown mechanism. Analyzing other scarring diseases (lichen planopilaris, fibrotic kidney disease, and scleroderma) may help clarify the mechanism of scarring in CCCA. These diseases were chosen for comparison due to either their location of disease (skin or scalp specifically), or prominence in patients of African descent. Read More

    Correlation between physical markers and psychiatric health in a Portuguese systemic lupus erythematosus cohort: The role of suffering in chronic autoimmune disease.
    PLoS One 2018 16;13(4):e0195579. Epub 2018 Apr 16.
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah, United States of America.
    Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects a large number of people throughout the world. Anxiety, depression and fatigue are common symptoms of SLE that substantially contribute to decreased quality of life. This study investigates the interplay between physical and psychiatric manifestations of lupus. Read More

    Efficacy and safety of a new 5% minoxidil formulation in male androgenetic alopecia: A randomized, placebo-controlled, double-blind, noninferiority study.
    J Cosmet Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    Pierre Fabre Dermatologie, Lavaur, France.
    Background: Androgenetic alopecia (AGA) is the most common cause of hair loss in men. Topical minoxidil solutions can help to treat AGA but have to be applied continuously to be effective.

    Objectives: A new minoxidil formulation with improved cosmetic characteristics (DC0120, Pierre-Fabre Dermatologie) was tested for noninferiority vs a comparator minoxidil product (ALOSTIL , Johnson & Johnson) in stimulating hair growth in men with AGA. Read More

    Nail involvement in patients with moderate to severe alopecia areata treated with oral tofacitinib.
    J Dermatolog Treat 2018 Apr 16:1-18. Epub 2018 Apr 16.
    a Department of Dermatology , SMG-SNU Boramae Medical Center , Seoul , Korea.
    Background: A few anecdotal case reports demonstrated that tofacitinib improved nail changes associated with AA.

    Objective: To investigate nail changes in patients with AA treated with tofacitinib and evaluate the relationship between nail and hair responses to tofacitinib.

    Methods: This is a retrospective study of 33 adult patients with moderate-to-severe AA treated with oral tofacitinib monotherapy for at least 4 months. Read More

    Prescribing Habits for Androgenic Alopecia Among Dermatologists in Spain in 2017: A Cross-Sectional Study.
    Actas Dermosifiliogr 2018 Apr 12. Epub 2018 Apr 12.
    Servicio de Dermatología, Hospital Ramón y Cajal, Madrid, España.
    Background: Topical minoxidil and oral finasteride are the only drugs approved for the treatment of androgenetic alopecia (AGA) in Spain. However, the management of this condition is highly variable because numerous treatments are used off-label. The main aim of this study was to describe the prescribing habits of dermatologists in Spain for male AGA (MAGA) and female AGA (FAGA). Read More

    [Clinical and genetic analysis of three pedigrees affected with myotonic dystrophy].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Apr;35(2):175-178
    Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China .
    Objective: To carry out clinical and genetic analysis for three pedigrees affected with myotonic dystrophy type 1 (DM1).

    Methods: Three probands with clinically diagnosed DM and their familial members were recruited. Clinical data of the patients including clinical manifestations, electrocardiogram (ECG), and electromyogram (EEG) was collected. Read More

    [A Case of Successful Treatment with Gemcitabine plus Nab-Paclitaxel Therapy for Nonresected Pancreatic Body Cancer(Stage IVb)].
    Gan To Kagaku Ryoho 2018 Mar;45(3):563-565
    Dept. of Surgery, Hasuda Hospital.
    A 61-year-old woman was introduced for consultation with a chief complaint of frequent vomiting. CT revealed a pancreatic body cancer approximately 40mm in size; an invading stenosis from the horizontal part of the duodenum to the jejunum, superior mesenteric artery, and portal vein, splenic vein obstruction, lymphadenopathy, and some ascitic fluid. We diagnosed a passage disorder due to the invasive stenosis from the horizontal part of the duodenum of the pancreatic body cancer to the jejunum, and subsequently performed a duodenum and jejunum bypass operation. Read More

    Cicatricial alopecia.
    J Dtsch Dermatol Ges 2018 Apr;16(4):435-461
    Department of Dermatology, Venereology, and Allergology, Charité - University Medical Center, Berlin, Germany.
    In the classification of the North American Hair Research Society, primary cicatricial alopecias (PCA) are divided into four groups according to their prominent inflammatory infiltrate: PCAs with lymphocytic, neutrophilic, mixed or nonspecific cell inflammation pattern. The hair loss can begin subclinically and progress slowly so that the exact onset of the disease is often difficult to determine. The diagnosis is often delayed. Read More

    Endocrine Therapy-Induced Alopecia in Patients With Breast Cancer.
    JAMA Dermatol 2018 Apr 11. Epub 2018 Apr 11.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Importance: Endocrine therapy-induced alopecia (EIA) has been anecdotally reported but not systematically described.

    Objective: To characterize EIA in patients with breast cancer.

    Design, Setting, And Participants: Retrospective cohort study of 112 patients with breast cancer, diagnosed with EIA from January 1, 2009, to December 31, 2016, the patients were examined at the dermatology service in a large tertiary care hospital and comprehensive cancer center. Read More

    Increased prevalence of vitamin D deficiency in patients with alopecia areata: A systematic review and meta-analysis.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Republic.
    Background: Alopecia areata (AA) is a hair follicle-specific autoimmune disorder. Vitamin D deficiency has been associated with various autoimmune disorders for its immunomodulatory effects. However, in previous studies, there had been inconsistent association found between AA and vitamin D deficiency. Read More

    Compound heterozygous mutations in desmoplakin associated with skin fragility, follicular hyperkeratosis, alopecia, and nail dystrophy.
    Pediatr Dermatol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology, School of Medicine, Indiana University, Indianapolis, IN, USA.
    Desmoplakin mutations are associated with a wide variety of phenotypes affecting the skin, nails, hair, and heart. A 21-month-old boy was born with multiple erosions resembling epidermolysis bullosa, complete alopecia, nail dystrophy, palmoplantar keratoderma, and areas of follicular hyperkeratosis. He was found to have two heterozygous mutations in the desmoplakin gene: c. Read More

    The side effects of platinum-based chemotherapy drugs: a review for chemists.
    Dalton Trans 2018 Apr 10. Epub 2018 Apr 10.
    Sydney Pharmacy School, The University of Sydney, NSW 2006, Australia.
    The platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events). In total, a cancer patient can experience any combination of around 40 specific side effects. The dose-limiting side effect for cisplatin is nephrotoxicity, for carboplatin it is myelosuppression, and for oxaliplatin it is neurotoxicity. Read More

    Hairline Restoration: Difference in Men and Woman-Length and Shape.
    Facial Plast Surg 2018 Apr 9;34(2):155-158. Epub 2018 Apr 9.
    Facial Plastic Surgery Associates, Clinic, Houston, Texas.
    Hair restoration has become increasingly popular in recent years with both men and women. New technologies such as follicular unit extraction and grafting have made it possible for patients to get a natural looking result with minimal downtime. Men usually experience hairline recession as a result of androgenic alopecia, while women most commonly experience thinning of the crown and vertex, with the preservation of the hairline. Read More

    STABILITY OF SOLUTIONS OF 2,3-DIPHENYLCYCLOPROPENONE IN VARIOUS SOLVENTS. A NOVEL FORMULA - DIPHENYLCYCLOPROPENONE IN ISOPROPANOL MAY BE USEFUL IN TOPICAL THERAPY OF PATIENTS WITH ALOPECIA AREATA.
    Acta Pol Pharm 2017 Mar;74(2):459-464
    The aim of this study was to evaluate the chemical stability of diphenylcyclopropenone (DCP) in var- ious solvents. DCP is being used in topical therapy in patients with alopecia areata (AA). The solvents for DCP used so far were acetone, ethanol and propylene glycol. Read More

    Sirolimus in Refractory Cronkhite-Canada Syndrome and Focus on Standard Treatment.
    J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618765893. Epub 2018 Mar 22.
    Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
    Cronkhite-Canada syndrome is a rare syndrome consisting of extensive gastrointestinal polyposis and ectodermal changes including cutaneous hyperpigmentation, alopecia, and onychodystrophy. We report the case of a 45-year-old Caucasian male patient who failed multiple treatments over 2 years including steroids, azathioprine, adalimumab, and cyclosporine. He had recurrent and prolonged hospitalizations because of diarrhea, abdominal pain, weight loss, and malnutrition. Read More

    A Case of Vogt-Koyanagi-Harada Syndrome Mimicking Optic Neuritis.
    J Coll Physicians Surg Pak 2018 Apr;28(4):325-326
    Department of Ophthalmology, Al-Khidmat Teaching Hospital, Mansoora / University College of Medicine and Dentistry, University of Lahore, Lahore.
    Vogt-Koyanagi-Harada syndrome is a rare disease that occurs commonly in pigmented individuals of Asian origin. A 25-year female presented in medical outpatient department (OPD) of Al-Khidmat Teaching Hospital, Mansoora, Lahore with headache and neck stiffness. She was referred to eye OPD for the complaint of decreased vision. Read More

    Disease Characteristics and Treatment Outcome of Testicular Germ Cell Tumors Treated with Platinum-Based Regimens.
    J Coll Physicians Surg Pak 2018 Apr;28(4):292-296
    Institute of Nuclear Medicine and Oncology (INMOL),Lahore.
    Objective: To determine the disease characteristics of testicular germ cell tumor, biochemical/radiological response to chemotherapy and common toxicity profile.

    Study Design: Case series.

    Place And Duration Of Study: Institute of Nuclear Medicine and Oncology (INMOL), Lahore, from January 2010 to December 2013. Read More

    Topical Hypochlorite and Skin Acidification Improves Erythroderma of Omenn Syndrome.
    Pediatrics 2018 Apr;141(Suppl 5):S408-S411
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio.
    We describe a case of Omenn syndrome displaying exudative erythroderma and other characteristic features, including alopecia, absent B and naïve T cells, hyper immunoglobulin E levels, and eosinophilia. A pathogenic recombination-activating homozygous genetic mutation confirmed the diagnosis. She required frequent antibiotics at both treatment and prophylactic doses, which alone did not control her erythroderma, but her high risk of infection precluded the use of systemic agents such as cyclosporine, which would further suppress her already severely compromised immune system. Read More

    Histopathology of Cutaneous Inflammatory Disorders in Children.
    Pediatr Dev Pathol 2018 Mar-Apr;21(2):115-149
    1 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
    Inflammatory dermatoses encompass a variety of histologic patterns that affect different portions of the skin. In spongiotic, psoriasiform, lichenoid, pityriasiform, and blistering disorders, there are predominately epidermal and junctional activities with variable superficial dermal inflammation. Hypersensitivity reactions can show either epidermal or mostly dermal changes depending on whether the exposure of the exogenous allergen occurs through an external or internal route, respectively. Read More

    Localized Telogen Effluvium Following Hair Transplantation.
    Ann Dermatol 2018 Apr 21;30(2):214-217. Epub 2018 Feb 21.
    Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
    Telogen effluvium is categorized in nonscarring alopecia, which shows scalp hair thinning and shedding diffusely resulting from inducing factors such as physiological stressful events and several acute or chronic diseases. It usually appears in female patients following parturition, as well as after febrile disease, major surgery, emotional stress, abrupt diet, chronic illness, or the taking of certain medication pills. Two patients who both recalled an operational history of hair transplantation visited our department with their frontal and both temporal hair loss. Read More

    Can the Cytokine Analysis of the Scales on Alopecic Patch Predict the Response to Diphenylcyclopropenone Treatment in Alopecia Areata Patients?
    Ann Dermatol 2018 Apr 21;30(2):150-157. Epub 2018 Feb 21.
    Department of Dermatology, Inha University School of Medicine, Incheon, Korea.
    Background: Contact immune modulating therapy with diphenylcyclopropenone (DPCP) is a topical treatment option for extensive alopecia areata (AA). Because the response to DPCP treatment varies according to the patient, and it takes several months to evaluate the clinical effectiveness of the treatment, it is necessary to identify the factors that can predict the prognosis of the disease while treating with topical DPCP.

    Objective: In this study, cytokine levels in the scales of alopecic patches were investigated to identify whether they could predict response to DPCP during the early treatment period. Read More

    Update on the use of trilostane in dogs.
    Can Vet J 2018 Apr;59(4):397-407
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1C 1G9.
    Many articles published in the past few years have contributed to a better understanding of the use of trilostane in dogs. Trilostane is a competitive inhibitor of 3β-hydroxysteroid dehydrogenase, the enzyme essential for synthesis of cortisol and all other steroids. Trilostane is reported to be safe and effective in the treatment of pituitary-dependent hyperadrenocorticism (HAC), adrenal-dependent HAC, and alopecia X. Read More

    A guide to studying human dermal adipocytes in situ.
    Exp Dermatol 2018 Mar 30. Epub 2018 Mar 30.
    Centre for Dermatology Research, The University of Manchester, Manchester, UK.
    Dermal white adipose tissue (DWAT) is a main component of human skin, composed of individual lipid-laden mesenchymal cells known as dermal adipocytes (DAs). Besides their well-known role in lipid storage and release, DAs also promote skin immunity, wound healing and hair follicle cycling and are important players in cutaneous neuro-endocrinology. The ever-growing insights into DWAT functions, albeit mostly in mice, have invited speculation that it may be involved in multiple skin diseases ranging from fibrosis to alopecia and psoriasis, thus designating human DWAT a clinically relevant, but as yet insufficiently investigated skin compartment. Read More

    Immune privilege disruption in folliculotropic mycosis fungoides: investigation of major histocompatibility complex antigen expression.
    Int J Dermatol 2018 Mar 30. Epub 2018 Mar 30.
    Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
    Background: Folliculotropic mycosis fungoides (FMF) is a cutaneous T-cell lymphoma mainly affecting the hair follicle, which seems to represent a place of immune privilege phenomenon.

    Objectives: To explore a possible role of immune privilege (IP) in FMF analyzing the major histocompatibility complex (MHC) expression.

    Methods: Immunohistochemistry for HLA-G and MHC-II was performed to formalin-fixed paraffin-embedded cutaneous skin biopsies of FMF patients (n = 43), conventional mycosis fungoides (CMF; n = 13), alopecia areata (AA; n = 13), and normal scalp skin (NS; n = 12). Read More

    A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women.
    J Drugs Dermatol 2018 Apr;17(4):457-463
    Introduction: Currently, only topical minoxidil (MNX) and oral finasteride (FNS) are approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of androgenetic alopecia. Although FNS is efficacious for hair regrowth, its systemic use is associated with side effects limiting long-term utilization. Exploring topical FNS as an alternative treatment regimen may prove promising. Read More

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