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    2301 results match your criteria Androgen Excess

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    High serum progesterone associated with infertility in a woman with nonclassic congenital adrenal hyperplasia.
    J Obstet Gynaecol Res 2017 Feb 11. Epub 2017 Feb 11.
    Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Nonclassic congenital adrenal hyperplasia (NCAH) is an autosomal-recessive disorder caused by 21-hydroxylase deficiency and manifests as hirsutism and oligomenorrhea due to excess adrenal androgen and progesterone. We report a case of a woman with NCAH who showed continuous high serum progesterone levels in the follicular phase associated with impaired folliculogenesis. NCAH was diagnosed based on high 17-hydroxyprogesterone levels after rapid adrenocorticotropic hormone loading, and three heterozygous missense mutations in CYP21A2, encoding 21-hydroxylase, were identified. Read More

    Sex differences in the effects of androgens acting in the central nervous system on metabolism.
    Dialogues Clin Neurosci 2016 Dec;18(4):415-424
    Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA.
    One of the most sexually dimorphic aspects of metabolic regulation is the bidirectional modulation of glucose and energy homeostasis by testosterone in males and females. Testosterone deficiency predisposes men to metabolic dysfunction, with excess adiposity, insulin resistance, and type 2 diabetes, whereas androgen excess predisposes women to insulin resistance, adiposity, and type 2 diabetes. This review discusses how testosterone acts in the central nervous system, and especially the hypothalamus, to promote metabolic homeostasis or dysfunction in a sexually dimorphic manner. Read More

    Is acne a sign of androgen excess disorder or not?
    Eur J Obstet Gynecol Reprod Biol 2017 Jan 23;211:21-25. Epub 2017 Jan 23.
    Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
    Objective: Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Read More

    Adrenocortical neoplasms in adulthood and childhood: distinct presentation. Review of the clinical, pathological, and imaging characteristics.
    J Pediatr Endocrinol Metab 2017 Feb 7. Epub 2017 Feb 7.
    Adrenocortical tumors (ACT) in adulthood and childhood vary in clinical, histopathological, molecular, prognostic, and imaging aspects. ACT are relatively common in adults, as adenomas are often found incidentally on imaging. ACT are rare in children, though they have a significantly higher prevalence in the south and southeast regions of Brazil. Read More

    Cryptotanshinone Regulates Androgen Synthesis through the ERK/c-Fos/CYP17 Pathway in Porcine Granulosa Cells.
    Evid Based Complement Alternat Med 2017 12;2017:5985703. Epub 2017 Jan 12.
    Research Institute of Integrated Traditional Chinese Medicine and Western Medicine, Guangzhou Medical University, Guangzhou 510120, China; Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
    The aim of the study is to investigate the molecular mechanism behind androgen reduction in porcine granulosa cells (pGCs) with Salvia miltiorrhiza Bunge extract cryptotanshinone. PGCs were isolated from porcine ovaries and identified. Androgen excess model of the pGCs was induced with the MAPK inhibitor PD98059 and then treated with cryptotanshinone. Read More

    Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review.
    Am J Clin Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    Background: The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required.

    Objective: Our aim was to conduct a hybrid systematic review of the evidence for benefits and potential harms of oral spironolactone in the management of acne in adult females. Read More

    Selective deletion of Pten in theca-interstitial cells leads to androgen excess and ovarian dysfunction in mice.
    Mol Cell Endocrinol 2017 Mar 28;444:26-37. Epub 2017 Jan 28.
    Department of OB/GYN & Women's Health, University of Louisville School of Medicine, Louisville, KY 40202, USA. Electronic address:
    Theca cell-selective Pten mutation (tPtenMT) in mice resulted in increases in PDK1 and Akt phosphorylation, indicating an over-activation of PI3K signaling in the ovaries. These mice displayed elevated androgen levels, ovary enlargement, antral follicle accumulation, early fertility loss and increased expression of Lhcgr and genes that are crucial to androgenesis. These abnormalities were partially reversed by treatments of PI3K or Akt inhibitor. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: update on the management of adult patients and prenatal treatment.
    Eur J Endocrinol 2017 Apr 23;176(4):R167-R181. Epub 2017 Jan 23.
    AP-HPIE3M, Hôpital Pitié-Salpêtrière, Department of Endocrinology and Reproductive Medicine and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Centre de Référence des Pathologies Gynécologiques Rares, ICAN, Paris, France
    Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is characterized by cortisol and in some cases aldosterone deficiency associated with androgen excess. Goals of treatment are to replace deficient hormones and control androgen excess, while avoiding the adverse effects of exogenous glucocorticoid. Over the last 5 years, cohorts of adults with CAH due to 21-hydroxylase deficiency from Europe and the United States have been described, allowing us to have a better knowledge of long-term complications of the disease and its treatment. Read More

    Premature pubarche in a child with abnormal 3β-hydroxysteroid dehydrogenase function and Klinefelter syndrome: the intriguing relationship between androgen deficiency and excess.
    Clin Case Rep 2017 Jan 20;5(1):57-60. Epub 2016 Dec 20.
    Department of Pediatrics Division of Pediatric Endocrinology Baystate Medical Center Springfield Massachusetts USA.
    Disorders of androgen excess may coexist with disorders of androgen deficiency, such as Klinefelter syndrome, and can create diagnostic and therapeutic challenges. Read More

    Prevalence of hormonal and endocrine dysfunction in patients with lichen planopilaris (LPP): A retrospective data analysis of 168 patients.
    J Am Acad Dermatol 2017 Feb;76(2):314-320
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:
    Background: Studies on the pathophysiology and comorbidities associated with lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are limited.

    Objective: The purpose of this study was to determine the prevalence of androgen excess in the postmenopausal LPP population, in relation to demographics and comorbidities.

    Methods: A retrospective data analysis of 413 patients with LPP, FFA, and LPP/FFA seen in the Department of Dermatology at the Cleveland Clinic Foundation in Ohio between 2005 and 2015 was conducted. Read More

    A Comparison of Sexual Function in Women with Polycystic Ovary Syndrome (PCOS) Whose Mothers Had PCOS During Their Pregnancy Period with Those Without PCOS.
    Arch Sex Behav 2017 Jan 9. Epub 2017 Jan 9.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive ages. Clinical symptoms associated with PCOS, such as hirsutism, acne, alopecia, obesity, and infertility, may lead to emotional morbidity and then impaired sexual function in those affected. During intrauterine development, the fetus may program the development of diseases during adulthood. Read More

    Effect of Exercise on Ovulation: A Systematic Review.
    Sports Med 2016 Dec 29. Epub 2016 Dec 29.
    Laboratory of Protein Biochemistry, Federal University of State of Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Infertility has been described as a devastating life crisis for couples, and has a particularly severe effect on women, in terms of anxiety and depression. Anovulation accounts for around 30% of female infertility, and while lifestyle factors such as physical activity are known to be important, the relationship between exercise and ovulation is multi-factorial and complex, and to date there are no clear recommendations concerning exercise regimes.

    Objectives: The objective of this review was to systematically assess the effect of physical activity on ovulation and to discuss the possible mechanisms by which exercise acts to modulate ovulation in reproductive-age women. Read More

    Metabolic and carbohydrate characteristics of different phenotypes of polycystic ovary syndrome.
    J Turk Ger Gynecol Assoc 2016 1;17(4):201-208. Epub 2016 Dec 1.
    Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey.
    Objective: To compare the prevalence of various metabolic and cardiovascular risk factors and insulin resistance between polycystic ovary syndrome (PCOS) patients with or without hyperandrogenism.

    Material And Methods: This is a retrospective cross-sectional study involving women with PCOS as diagnosed according to the Androgen Excess (AE) Society definition (n=504) and women with normoandrogenemic PCOS (n=183). Anthropometrics, lipid profile, glucose, insulin, oral glucose tolerance test (OGTT), and reproductive hormone levels were evaluated. Read More

    Adrenal disorders and nonalcoholic fatty liver disease.
    Minerva Endocrinol 2016 Dec 14. Epub 2016 Dec 14.
    Unit of Translation and Clinical Research in Endocrinology, University of Athens Medical School, Athens, Greece.
    Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the developed world and its pathogenesis is complex and multifactorial. It is considered the hepatic manifestation of the metabolic syndrome and is the leading cause of hepatic cirrhosis. This review aims to present current knowledge on the involvement of the adrenal glands in the development of NAFLD. Read More

    Low Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and Nuclear Hepatic Androgen Receptor Mechanisms.
    Endocrinology 2016 Dec 14:en20161553. Epub 2016 Dec 14.
    Division of Pediatric Endocrinology, Johns Hopkins School of Medicine, Baltimore, MD.
    Androgen excess in women is associated with metabolic dysfunction (obesity, hyperinsulinemia, insulin resistance, and increased risk of type 2 diabetes (T2D)) and reproductive dysfunction (polycystic ovaries, amenorrhea, dysregulated gonadotropin release, and infertility). We sought to identify the effects of androgen excess on glucose metabolic dysfunction and the specific mechanisms of action by which androgens are inducing pathology. We developed a mouse model that displayed pathophysiological serum androgen levels with normal body mass/composition to ensure that the phenotypes were directly from androgens and not an indirect consequence of obesity. Read More

    Gestational Hyperandrogenism in Developmental Programming.
    Endocrinology 2016 Dec 14:en20161801. Epub 2016 Dec 14.
    3 Department of Pediatrics Texas Tech Health Sciences Permian Basin 79763.
    Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. Potential causes of androgen excess in women include: polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity amongst many others. During pregnancy, luteoma, placental aromatase deficiency, and fetal CAH are additional causes of gestational hyperandrogenism. Read More

    Growth of a progesterone receptor-positive meningioma in a female patient with congenital adrenal hyperplasia.
    Endocrinol Diabetes Metab Case Rep 2016 21;2016. Epub 2016 Nov 21.
    Department of Endocrinology , Adelaide and Meath Hospitals, incorporating the National Children's Hospital, Tallaght, Dublin , Ireland.
    : Meningioma growth has been previously described in patients receiving oestrogen/progestogen therapy. We describe the clinical, radiological, biochemical and pathologic findings in a 45-year-old woman with congenital adrenal hyperplasia secondary to a defect in the 21-hydroxylase enzyme who had chronic poor adherence to glucocorticoid therapy with consequent virilisation. The patient presented with a frontal headache and marked right-sided proptosis. Read More

    Clinical perspectives in congenital adrenal hyperplasia due to 11β-hydroxylase deficiency.
    Endocrine 2017 Jan 7;55(1):19-36. Epub 2016 Dec 7.
    Department of Endocrinology, Royal Darwin Hospital, Darwin, NT, Australia.
    Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency is a rare autosomal recessive genetic disorder. It is caused by reduced or absent activity of 11β-hydroxylase (CYP11B1) enzyme and the resultant defects in adrenal steroidogenesis. The most common clinical features of 11 beta-hydroxylase deficiency are ambiguous genitalia, accelerated skeletal maturation and resultant short stature, peripheral precocious puberty and hyporeninemic hypokalemic hypertension. Read More

    Polycystic ovary syndrome in adolescent girls.
    Curr Opin Endocrinol Diabetes Obes 2017 Feb;24(1):56-66
    Division of Pediatric Endocrinology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA.
    Purpose Of Review: Polycystic ovary syndrome (PCOS) is a common heterogeneous disorder that appears to have its origins during the peripubertal years. The diagnostic conundrum is that the typical clinical features, irregular menses and acne, occur during normal female puberty. Understanding the physiologic origins and molecular basis of the dysregulated hypothalamic-pituitary-gonadal axis in PCOS is fundamental to interrupting the distinctive vicious cycle of hyperandrogenism and chronic anovulation. Read More

    Bilateral testicular tumors resulting in recurrent Cushing's syndrome after bilateral adrenalectomy".
    J Clin Endocrinol Metab 2016 Nov 30:jc20162702. Epub 2016 Nov 30.
    1 Department of Medicine, Division of Endocrinology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
    Context: Recurrence of hypercortisolism in patients after bilateral adrenalectomy for Cushing's disease is extremely rare.

    Patient: We present a rare case of a 27-year-old man who previously underwent bilateral adrenalectomy for Cushing's disease with complete clinical resolution. Cushingoid features recurred 12 years later, along with bilateral testicular enlargement. Read More

    11-oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome.
    J Clin Endocrinol Metab 2016 Nov 30:jc20163285. Epub 2016 Nov 30.
    1 Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT.
    Context: Androgen excess is a defining feature of polycystic ovary syndrome (PCOS) but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to the androgen excess phenotype in women with PCOS. Read More

    Maternal Polycystic Ovary Syndrome and Risk for Attention-Deficit/Hyperactivity Disorder in the Offspring.
    Biol Psychiatry 2016 Oct 6. Epub 2016 Oct 6.
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. Electronic address:
    Background: Attention-deficit/hyperactivity disorder (ADHD) is the most common childhood neurodevelopmental disorder, and boys are two to three times more likely to develop ADHD. Maternal polycystic ovary syndrome (PCOS), a common metabolic disorder associated with excess circulating androgens, has been associated with increased risk for autism spectrum disorder in the offspring. In this study, we aimed to investigate whether maternal PCOS increases the risk for ADHD in the offspring. Read More

    Polycystic ovarian syndrome: clinical and biological diagnosis.
    Ann Biol Clin (Paris) 2016 Dec;74(6):661-667
    Service d'endocrinologie et médecine de la reproduction et Centre de référence des maladies endocriniennes rares de la croissance, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France ; UPMC Université Paris 6, Paris, France.
    Polycystic ovary syndrome (PCOS) is the most common ovarian disorder associated with androgen excess in women, which justifies the growing interest of endocrinologists. This syndrome leads to clinical hyperandrogenism and/or a biological dysovulation and infertility. Its diagnosis is based on consensual diagnostic criteria, but which are likely to change in the near future with the rise of the interest of new markers such as AMH. Read More

    Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia.
    J Clin Endocrinol Metab 2016 Nov 15:jc20162855. Epub 2016 Nov 15.
    1 Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK.
    Context: The classic androgen synthesis pathway proceeds via DHEA, androstenedione and testosterone to 5α-dihydrotestosterone (DHT). However, DHT synthesis can also be achieved by an alternative pathway originating from 17α-hydroxyprogesterone (17OHP), which accumulates in congenital adrenal hyperplasia (CAH). Similarly, recent work has highlighted androstenedione-derived 11-oxygenated 19-carbon steroids as active androgens and, in CAH, androstenedione is generated directly from 17OHP. Read More

    Association between the angiotensin converting enzyme gene insertion/deletion polymorphism and metabolic disturbances in women with polycystic ovary syndrome.
    Mol Med Rep 2016 Dec 31;14(6):5401-5407. Epub 2016 Oct 31.
    Department of Infertility and Reproductive Endocrinology, Poznań University of Medical Sciences, 60‑535 Poznań, Poland.
    Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. A number of PCOS complications may be associated with the elevated level of angiotensin II and low bradykinin concentrations. The aim of the present study was to investigate the frequencies of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms in women with PCOS and to determine the association between ACE genetic variants and the risk of metabolic and cardiovascular complications in such women. Read More

    Spatiotemporal dynamics of androgen signaling underlie sexual differentiation and congenital malformations of the urethra and vagina.
    Proc Natl Acad Sci U S A 2016 Nov 7;113(47):E7510-E7517. Epub 2016 Nov 7.
    Department of Molecular Genetics and Microbiology, University of Florida Genetics Institute, University of Florida, Gainesville, FL 32610.
    Disorders of sex development (DSDs) are congenital anomalies that affect sexual differentiation of genitourinary organs and secondary sex characters. A common cause of female genital virilization is congenital adrenal hyperplasia (CAH), in which excess androgen production during development of 46XX females can result in vaginal atresia, masculinization of the urethra, a single urogenital sinus, and clitoral hypertrophy or ambiguous external genitalia. Development of the vagina depends on sexual differentiation of the urogenital sinus ridge, an epithelial thickening that forms where the sex ducts attach to the anterior urethra. Read More

    Plexiform schwannoma: an unusual clitoral mass.
    Am J Obstet Gynecol 2016 Nov 3. Epub 2016 Nov 3.
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI.
    Acquired clitoral enlargement is a rare condition resulting from a variety of etiologies, including tumors and excess androgens. Few cases of nonmalignant schwannoma, a benign tumor of the peripheral nerve sheath, have been reported in the literature as causes of clitoral enlargement in patients without known neurofibromatosis. These painless, slow-growing tumors rarely recur once excised. Read More

    Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance.
    Obesity (Silver Spring) 2016 Nov;24(11):2399-2406
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
    Objective: Increased liver fat and type 2 diabetes are prevalent in women with polycystic ovarian syndrome (PCOS) and cause excess mortality, yet little is known about their development during adolescence. The objective of this study was to measure hepatic steatosis and related metabolic contributors in girls with obesity, with and without PCOS.

    Methods: Nondiabetic adolescents with obesity, 41 with PCOS (PCOS; age 15. Read More

    Hypogonadism alters cecal and fecal microbiota in male mice.
    Gut Microbes 2016 Nov 22;7(6):533-539. Epub 2016 Sep 22.
    a Division of Applied Life Sciences , Graduate School of Life and Environmental Sciences, Osaka Prefecture University , Sakai , Osaka , Japan.
    Low testosterone levels increase the risk for cardiovascular disease in men and lead to shorter life spans. Our recent study showed that androgen deprivation via castration altered fecal microbiota and exacerbated risk factors for cardiovascular disease, including obesity, impaired fasting glucose, excess hepatic triglyceride accumulation, and thigh muscle weight loss only in high-fat diet (HFD)-fed male mice. However, when mice were administered antibiotics that disrupted the gut microbiota, castration did not increase cardiovascular risks or decrease the ratio of dried feces to food intake. Read More

    Does Fluoride Affect Serum Testosterone and Androgen Binding Protein with Age-Specificity? A Population-Based Cross-Sectional Study in Chinese Male Farmers.
    Biol Trace Elem Res 2016 Dec 6;174(2):294-299. Epub 2016 May 6.
    Department of Occupational and Environmental Health, Institute of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China.
    Many studies have demonstrated that exposure to excess fluoride was associated with a variety of diseases. Little is known about the variation of testosterone (T) levels caused by fluoride exposure. The aim of this study is to explore the association of fluoride exposure and age with serum T and androgen-binding protein (ABP) levels in male farmers. Read More

    Excess Testosterone Exposure Alters Hypothalamic-Pituitary-Testicular Axis Dynamics and Gene Expression in Sheep Fetuses.
    Endocrinology 2016 Nov 27;157(11):4234-4245. Epub 2016 Sep 27.
    Department of Physiology and Pharmacology (C.E.R., R.A., K.P.G.), Oregon Health and Science University, Portland, Oregon 97239-3098; and Department of Animal and Rangeland Sciences (K.C., F.S., C.T.E.) and College of Veterinary Medicine (C.T.E.), Oregon State University, Corvallis, Oregon 97331-4501.
    Prenatal exposure to excess androgen may result in impaired adult fertility in a variety of mammalian species. However, little is known about what feedback mechanisms regulate gonadotropin secretion during early gestation and how they respond to excess T exposure. The objective of this study was to determine the effect of exogenous exposure to T on key genes that regulate gonadotropin and GnRH secretion in fetal male lambs as compared with female cohorts. Read More

    Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A.
    Endocrinology 2016 Nov 27;157(11):4473-4486. Epub 2016 Sep 27.
    Department of Medicine (L.D.T., M.S.R., A.F., C.F.), Unit of Andrology and Reproductive Medicine, University of Padova and Department of Laboratory Medicine (M.P.), University-Hospital, 35128 Padova, Italy; Department of Molecular Medicine (D.G.), University of Padova Medical School, 35121 Padova, Italy; Laboratory of Protein Chemistry (V.D.F., S.T.), Department of Pharmaceutical and Pharmacological Sciences, School of Medicine, University of Padova, 35131 Padova, Italy; and European Academy of Bozen/Bolzano (G.S.), Institute of Mountain Emergency Medicine, 39100 Bolzano, Italy.
    The undercarboxylated form of osteocalcin (ucOC) regulates male fertility and energy metabolism, acting through the G protein-coupled receptor (GPRC)6A, thus forming a new pancreas-bone-testis axis. Recently, GPRC6A has also been suggested to mediate the nongenomic responses of free testosterone (T). However, these data did not consider the physiological scenario, where circulating T is mainly bound to sex hormone-binding globulin (SHBG) and only a small percentage circulates freely in the blood. Read More

    Comorbidity and age cannot explain variation in life expectancy associated with treatment of non-metastatic prostate cancer.
    World J Urol 2016 Oct 28. Epub 2016 Oct 28.
    Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada.
    Introduction: Age and Charlson comorbidity index (CCI) affect life expectancy (LE) and other-cause mortality (OCM) in non-metastatic prostate cancer (nmPCa) patients. We examined their ability to predict OCM in individuals treated with radical prostatectomy (RP), brachytherapy (BT), external beam radiation (EBRT) androgen deprivation (ADT) or observation. We postulated that these variables are not sufficient to explain OCM and LE patterns according to different treatment types. Read More

    Inositol Treatment and ART Outcomes in Women with PCOS.
    Int J Endocrinol 2016 4;2016:1979654. Epub 2016 Oct 4.
    Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
    Polycystic ovary syndrome (PCOS) affects 5-10% of women in reproductive age and is characterized by oligo/amenorrhea, androgen excess, insulin resistance, and typical polycystic ovarian morphology. It is the most common cause of infertility secondary to ovulatory dysfunction. The underlying etiology is still unknown but is believed to be multifactorial. Read More

    Testosterone differentially regulates targets of lipid and glucose metabolism in liver, muscle and adipose tissues of the testicular feminised mouse.
    Endocrine 2016 Nov 4;54(2):504-515. Epub 2016 Aug 4.
    Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK.
    Testosterone deficiency is commonly associated with obesity, metabolic syndrome, type 2 diabetes and their clinical consequences-hepatic steatosis and atherosclerosis. The testicular feminised mouse (non-functional androgen receptor and low testosterone) develops fatty liver and aortic lipid streaks on a high-fat diet, whereas androgen-replete XY littermate controls do not. Testosterone treatment ameliorates these effects, although the underlying mechanisms remain unknown. Read More

    Apparent diffusion coefficient measurement of ovarian stroma: A potential tool for the diagnosis of polycystic ovary syndrome.
    Diagn Interv Imaging 2017 Jan 20;98(1):57-61. Epub 2016 Oct 20.
    Department of radiology, Cerrahpasa faculty of medicine, Istanbul university, KMPasa, Cerrahpasa Medical, Kocamustapasa street, 34098 Fatih/Istanbul, Turkey. Electronic address:
    Purpose: The purpose of this study was to assess the diagnostic value of measuring the apparent diffusion coefficient (ADC) of ovarian stroma in polycystic ovary syndrome (PCOS).

    Materials And Methods: This study was approved by the institutional review board and informed consent was obtained from each women. A total of 17 women (mean age, 22. Read More

    High Serum Tumor Necrosis Factor-Alpha Levels in Women with Polycystic Ovary Syndrome: A Meta-Analysis.
    PLoS One 2016 20;11(10):e0164021. Epub 2016 Oct 20.
    Department of Obstetrics and Gynecology, Clinical Medical College of Yangzhou University (Subei People's Hospital of Jiangsu Province), Yangzhou, Jiangsu, China.
    The objective of the study is to assess the TNF-α levels in PCOS patients and healthy controls. A comprehensive electronic search in Medline, Embase, and the Cochrane Library database was conducted up to July 2016. Random-effects model was used to estimate the standardized mean differences (SMDs) with 95% confidence intervals (CIs). Read More

    Perinatal exposure to androgen excess and the effects on the rat uterine estradiol responsiveness.
    Environ Toxicol 2016 Nov 30;31(11):1460-1468. Epub 2015 May 30.
    Department of Morphology, Institute of Biosciences, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
    Androgen exposure during sexual development induces alterations in steroidal target tissues. The objective of this study was to evaluate the uterine responsiveness to estradiol after perinatal androgenization. Pregnant Wistar rats were exposed to corn oil or testosterone propionate at 0. Read More

    Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer.
    Sci Rep 2016 Oct 17;6:35354. Epub 2016 Oct 17.
    Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) is a validated treatment target for the treatment of metastatic castration-resistant prostate cancer (CRPC). Abiraterone acetate (AA) inhibits both 17α-hydroxylase (hydroxylase) and 17,20-lyase (lyase) reactions catalyzed by CYP17A1 and thus depletes androgen biosynthesis. However, coadministration of prednisone is required to suppress the mineralocorticoid excess and cortisol depletion that result from hydroxylase inhibition. Read More

    A cross-sectional study to assess any possible linkage of C/T polymorphism in CYP17A1 gene with insulin resistance in non-obese women with polycystic ovarian syndrome.
    Indian J Med Res 2016 Jun;143(6):739-747
    Department of Biochemistry, Burdwan Medical College & Hospital, Burdwan, India.
    Background & Objectives: Insulin resistance (IR) is a major confounding factor in polycystic ovarian syndrome (PCOS) irrespective of obesity. Its exact mechanism remains elusive till now. C/T polymorphism in the -34 promoter region of the CYP17 gene is inconsistently attributed to elucidate the mechanism of IR and its link to hyperandrogenemia in obese PCOS patients. Read More

    The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis.
    Hum Reprod 2016 Dec 22;31(12):2841-2855. Epub 2016 Sep 22.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Hacettepe University, 06100, Sihhiye, Ankara, Turkey
    Study Question: What is the reported overall prevalence of polycystic ovary syndrome (PCOS) according to the criteria of the National Institutes of Health (NIH), Rotterdam or the Androgen Excess and PCOS Society (AE-PCOS Society)?

    Summary Answer: The reported overall prevalence of PCOS (95% CI) according to diagnostic criteria of the NIH, Rotterdam and the AE-PCOS Society is 6% (5-8%, n = 18 trials), 10% (8-13%, n = 15 trials) and 10% (7-13%, n = 10 trials), respectively.

    What Is Already Known: PCOS is the most common endocrine disorder among women of reproductive age. Although many studies have investigated the prevalence of PCOS, there are discrepancies in their results, in part due to the use of various definitions of the syndrome and its subphenotypes, differences between study cohorts, ethnicities, and types of recruitment and sampling. Read More

    Effects of 17β-Estradiol and Androgen on Glucose Metabolism in Skeletal Muscle.
    Endocrinology 2016 Dec 21;157(12):4691-4705. Epub 2016 Sep 21.
    Laboratory of Molecular Life Science (A.I., Y.N.), Institute of Biomedical Research and Innovation, Kobe 650-0047, Japan; Department of Diabetes and Genes (A.I., O.I.), Advanced Medical Initiatives, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Department of Health Promotion Sciences (N.L.F.), Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo 192-0397, Japan; and Faculty of Sports and Health Science (Y.H.) and Institute for Physical Activity (Y.H.), Fukuoka University, Fukuoka 814-0180, Japan.
    Diabetes develops predominantly in males in experimental models, and extensive evidence suggests that 17β-estradiol (E2) modulates progression of diabetes in humans. We previously developed a severely diabetic transgenic (Tg) mouse model by β-cell-specific overexpression of inducible cAMP early repressor (ICER) and found that male ICER-Tg mice exhibit sustained severe hyperglycemia, but female ICER-Tg mice gradually became normoglycemic with aging. This implies that differences in circulating androgen and E2 levels might influence skeletal muscle glucose uptake and glycemic status. Read More

    Executive functioning in children with congenital adrenal hyperplasia.
    J Investig Med 2017 Jan 15;65(1):49-52. Epub 2016 Sep 15.
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
    Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is a disorder characterized by impaired cortisol synthesis leading to excessive production of adrenal androgens. Prenatal and postnatal exposure to excess androgens may increase neural vulnerability to insult and affect cognitive functions, particularly dopamine-dependent neural circuits responsible for executive functioning (EF). Our study aimed to investigate relationship between more pronounced androgen exposure and EF-related behaviors in children with CAH, as well as sex differences in these associations. Read More

    Antisecretive and Antitumor Activity of Abiraterone Acetate in Human Adrenocortical Cancer: A Preclinical Study.
    J Clin Endocrinol Metab 2016 Dec 14;101(12):4594-4602. Epub 2016 Sep 14.
    Section of Pharmacology, Department of Molecular and Translational Medicine (C.F., M.F., S.V., S.A.B., D.G., C.M., M.M., S.S.), University of Brescia, 25123 Brescia, Italy; Molecular Pharmacology Unit (P.P., M.T., N.Z.), Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy; Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health (M.C., A.B.), University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy; Surgical Clinic, Department of Clinical and Experimental Sciences (G.A.T.), University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy; Internal Medicine 1, Department of Clinical and Biological Sciences (M.T.), University of Turin, San Luigi Gonzaga Hospital, 10043 Orbassano, Italy; and Medical Oncology I, Genitourinary Unit (G.P.), Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
    Context: Patients with adrenocortical carcinoma (ACC) frequently suffer from cortisol excess, which portends a negative prognosis. Rapid control of cortisol hypersecretion and tumor growth are the main goals of ACC therapy. Abiraterone acetate (AA) is a potent inhibitor of 17alpha-hydroxylase/17,20-lyase, a key enzyme of adrenal steroidogenesis. Read More

    Localized Hypertrichosis Following Vaccination in an Infant.
    Int J Trichology 2016 Apr-Jun;8(2):84-6
    Department of Dermatology, Swami Dayanand Hospital, New Delhi, India.
    Hypertrichosis is characterized by increased hair growth independent of androgen excess. There are various causes of acquired localized hypertrichosis including chronic irritation and inflammation. Localised hypertrichosis following pentavalent vaccine has not been described previously in Indian literature. Read More

    eRah: A Computational Tool Integrating Spectral Deconvolution and Alignment with Quantification and Identification of Metabolites in GC/MS-Based Metabolomics.
    Anal Chem 2016 Oct 14;88(19):9821-9829. Epub 2016 Sep 14.
    Metabolomics Platform, Department of Electronic Engineering (DEEEA), Universitat Rovira i Virgili , 43003 Tarragona, Catalonia, Spain.
    Gas chromatography coupled to mass spectrometry (GC/MS) has been a long-standing approach used for identifying small molecules due to the highly reproducible ionization process of electron impact ionization (EI). However, the use of GC-EI MS in untargeted metabolomics produces large and complex data sets characterized by coeluting compounds and extensive fragmentation of molecular ions caused by the hard electron ionization. In order to identify and extract quantitative information on metabolites across multiple biological samples, integrated computational workflows for data processing are needed. Read More

    Endocrine Society of Australia position statement on male hypogonadism (part 2): treatment and therapeutic considerations.
    Med J Aust 2016 Sep;205(5):228-31
    Hudson Institute of Medical Research, Melbourne, VIC.
    Introduction: Part 1 of this position statement dealt with the assessment of male hypogonadism, including the indications for testosterone therapy. This article, Part 2, focuses on treatment and therapeutic considerations for male hypogonadism and identifies key questions for future research.

    Main Recommendations: Key points and recommendations are:Excess cardiovascular events have been reported in some but not all studies of older men without pathological hypogonadism who were given testosterone treatment. Read More

    Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols.
    Int J Endocrinol 2016 4;2016:6306410. Epub 2016 Aug 4.
    Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, 98125 Messina, Italy.
    Polycystic ovary syndrome (PCOS) is characterized by chronical anovulation and hyperandrogenism which may be present in a different degree of severity. Insulin-resistance and hyperinsulinemia are the main physiopathological basis of this syndrome and the failure of inositol-mediated signaling may concur to them. Myo (MI) and D-chiro-inositol (DCI), the most studied inositol isoforms, are classified as insulin sensitizers. Read More

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