2,465 results match your criteria Androgen Excess


Hyperandrogenism Induces Histo-Architectural Changes in the Rat Uterus.

Reprod Sci 2018 Jan 1:1933719118783881. Epub 2018 Jan 1.

1 Instituto de Salud y Ambiente del Litoral (ISAL UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.

The effects of androgens on the uterus have been poorly studied and they need to be clarified to understand why androgen excess, such as observed in women with polycystic ovary syndrome (PCOS), is a risk factor for the development of endometrial hyperplasia, cancer, and infertility. Thus, uterine histomorphology in a PCOS experimental model was evaluated. Beginning at weaning, female rats were injected daily with dehydroepiandrosterone (DHEA, 6 mg/100 g body weight) or vehicle (sesame oil) for 20 consecutive days. Read More

View Article
January 2018

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes.

JCI Insight 2018 Jun 21;3(12). Epub 2018 Jun 21.

Department of Medicine, Section of Endocrinology and Metabolism, and.

Androgen excess predisposes women to type 2 diabetes (T2D), but the mechanism of this is poorly understood. We report that female mice fed a Western diet and exposed to chronic androgen excess using dihydrotestosterone (DHT) exhibit hyperinsulinemia and insulin resistance associated with secondary pancreatic β cell failure, leading to hyperglycemia. These abnormalities are not observed in mice lacking the androgen receptor (AR) in β cells and partially in neurons of the mediobasal hypothalamus (MBH) as well as in mice lacking AR selectively in neurons. Read More

View Article

Metabolic Syndrome in Polycystic Ovary Syndrome.

Authors:
Renato Pasquali

Front Horm Res 2018 5;49:114-130. Epub 2018 Apr 5.

Both prevalence and incidence of the metabolic syndrome is very high in women with polycystic ovary syndrome (PCOS). Obesity and visceral fat enlargement play a dominant role in determining the final phenotype of PCOS. Androgen excess and insulin resistance may be responsible for the development of all features of the metabolic syndrome. Read More

View Article
April 2018
1 Read

Monogenic Disorders of Adrenal Steroidogenesis.

Horm Res Paediatr 2018 Jun 6:1-19. Epub 2018 Jun 6.

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.

Disorders of adrenal steroidogenesis comprise autosomal recessive conditions affecting steroidogenic enzymes of the adrenal cortex. Those are located within the 3 major branches of the steroidogenic machinery involved in the production of mineralocorticoids, glucocorticoids, and androgens. This mini review describes the principles of adrenal steroidogenesis, including the newly appreciated 11-oxygenated androgen pathway. Read More

View Article
June 2018
1 Read

Hypomethylation of specific CpG sites in the promoter region of steroidogeneic genes (GATA6 and StAR) in prenatally androgenized rats.

Life Sci 2018 May 30. Epub 2018 May 30.

Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences (RIES), Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address:

Introduction: The methylation level of promoters is one of the most studied and well-known epigenetic mechanisms that programs the amount of gene expression. Over expression of steroidogenesis genes via epigenetic control can result in hypetandrogenism, which is the main endocrine aspect of polycystic ovarian syndrome (PCOS).

Aims: In the present study we aimed to determine and compare the promoter methylation levels of three steroidogenic genes, CYP17, GATA6 and StAR, in theca cells of prenatally androgenized (PNA) rats to those of controls. Read More

View Article

Cardiometabolic risk in polycystic ovary syndrome.

Endocr Connect 2018 May 29. Epub 2018 May 29.

M Pfeifer, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age. Besides hyperandrogenism, oligomenorrhea and fertility issues, it is associated with a high prevalence of metabolic disorders and cardiovascular risk factors. Several genetic polymorphisms have been identified for possible associations with cardiometabolic derangements in PCOS. Read More

View Article

Clitoromegaly in Childhood and Adolescence: Behind One Clinical Sign, a Clinical Sea.

Sex Dev 2018 May 26. Epub 2018 May 26.

The clitoris is a highly complex organ whose structure has only been clarified in recent years through the use of modern imaging techniques. Clitoromegaly is an abnormal enlargement of this organ. It may be congenital or acquired and is usually due to an excess of androgens in fetal life, infancy, or adolescence. Read More

View Article

The diagnosis of PCOS in young infertile women according to different diagnostic criteria: the role of serum anti-Müllerian hormone.

Arch Gynecol Obstet 2018 Jul 25;298(1):207-215. Epub 2018 May 25.

Section of Gynecology and Obstetrics, Academic Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.

Purpose: To diagnose polycystic ovary syndrome (PCOS) in young infertile women using different diagnostic criteria. To define serum anti-Müllerian hormone (AMH) cutoff values for PCOS definition. To investigate the correlation between AMH and body mass index (BMI). Read More

View Article
July 2018
1 Read

[Virilization as demonstration of hypertestosteronism by ovarian tumor: case report].

Vnitr Lek 2018 ;64(4):437-440

Hypertestosteronism as part of hyperandrogenic states in women is generally defined as abundance of male hormones (in this case abundance of testosterone). Spectrum of clinical symptoms include menstrual disorders, amenorrhoea, different range of hirsutism and virilization. Statistically, most androgen secreting tumors are ovarian aetiology (testosterone secreting tumors located in suprarenal gland are very rare). Read More

View Article
January 2018
4 Reads

Adult Premenopausal Bone Health Related to Reproductive Characteristics-Population-Based Data from the Canadian Multicentre Osteoporosis Study (CaM).

Int J Environ Res Public Health 2018 May 18;15(5). Epub 2018 May 18.

Centre for Menstrual Cycle and Ovulation Research; University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

Amenorrhea is important for women's bone health. However, few have reported reproductive, anthropometric (body mass index [BMI], height) and bone health (areal bone mineral density [BMD], prevalent fractures) in a population-based study. The purposes of this cross-sectional study of women in the randomly-selected Canadian Multicentre Osteoporosis Study (CaM) population were: (1) to describe reproductive, demographic, anthropometric and lifestyle variables; and (2) in menstruating women, to relate reproductive and other variables to BMD at the lumbar spine (L1-4, LS), femoral neck (FN) and total hip (TH) sites and to prevalent fragility fractures. Read More

View Article

Androgen Excess- Polycystic Ovary Syndrome Society: position statement on depression, anxiety, quality of life, and eating disorders in polycystic ovary syndrome.

Fertil Steril 2018 May;109(5):888-899

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University and Monash Health, Clayton, Victoria, Australia.

Objective: To formulate clinical consensus recommendations for screening depression, anxiety, health-related quality of life (HRQoL), and disordered eating symptoms in women with polycystic ovary syndrome (PCOS) and review prevalence based on phenotypes and ethnicity, changes over time, etiology, and impact of treatment.

Design: Systematic reviews and preparation of position statement.

Setting: Not applicable. Read More

View Article

Follicular hyperandrogenism and insulin resistance in polycystic ovary syndrome patients with normal circulating testosterone levels.

J Biomed Res 2017 11 1. Epub 2017 Nov 1.

Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

Polycystic ovary syndrome (PCOS) is a common reproductive disease with high heterogeneity. The role of excess androgen in PCOS etiology remains disputed, since around 20%-50% of PCOS women do not display hyperandrogenemia. The microenvironment of the ovary critically influences follicular development. Read More

View Article
November 2017
1 Read

Adrenocortical Carcinoma with Hypercortisolism.

Endocrinol Metab Clin North Am 2018 Jun 9;47(2):395-407. Epub 2018 Apr 9.

Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, Regione Gonzole 10, Orbassano 10043, Italy. Electronic address:

Adrenocortical carcinoma (ACC) is a rare and aggressive tumor. ACC may be associated with different syndromes of hormone excess, most frequently Cushing's syndrome with or without hypersecretion of androgens. Recent data suggest that cortisol excess is a negative prognostic factor in advanced and localized ACC. Read More

View Article

Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1.

J Biol Chem 2018 Jun 9;293(25):9724-9735. Epub 2018 May 9.

From the Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham B15 2TT, United Kingdom.

The high-energy sulfate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways. Sulfotransferase SULT2A1 uses PAPS for sulfation of the androgen precursor dehydroepiandrosterone (DHEA), thereby reducing downstream activation of DHEA to active androgens. Human mutations manifest with undetectable DHEA sulfate, androgen excess, and metabolic disease, suggesting that ubiquitous PAPSS1 cannot compensate for deficient PAPSS2 in supporting DHEA sulfation. Read More

View Article
June 2018
1 Read

Hepatocellular Carcinoma, Virilization, and Hilus Cell Hyperplasia in a Girl With Turner Syndrome.

J Endocr Soc 2018 May 13;2(5):471-475. Epub 2018 Apr 13.

Pediatric Hematology Oncology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Patients with Turner syndrome (TS) are known to be at risk for excess androgen production and virilization associated with gonadoblastoma and Y chromosome mosaicism, and excess androgens are a risk factor for the development of hepatocellular carcinoma. However, virilization and hepatocellular carcinoma have not been described in a patient with TS. A 10-year-old with nonmosaic 45,X TS presented with clitoromegaly, accelerated linear growth velocity, advanced bone age, and elevated testosterone levels as well as a second occurrence of hepatocellular carcinoma. Read More

View Article

Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease.

Exp Ther Med 2018 May 6;15(5):4259-4264. Epub 2018 Mar 6.

Department of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, P.R. China.

The risk factors related to polycystic ovary syndrome (PCOS) patients complicated with non-alcoholic fatty liver disease (NAFLD) were investigated. A total of 188 PCOS patients treated in Shengli Oilfield Central Hospital (Dongying, China) from February 2014 to February 2015 were retrospectively analyzed as PCOS group, and PCOS group was further divided into NAFLD group and non-NAFLD (N-NAFLD) group according to the liver B ultrasound. In the same time-period, 65 healthy people were selected as normal control group. Read More

View Article

Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome.

Biomed Res Int 2018 8;2018:6869705. Epub 2018 Mar 8.

Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, China.

Women with polycystic ovary syndrome (PCOS) show high prevalence of glucose intolerance. This study aimed to investigate the association of androgen excess with glucose intolerance in PCOS. A total of 378 women with PCOS participated in the study. Read More

View Article
March 2018
1 Read

Establishing the cut off values of androgen markers in the assessment of polycystic ovarian syndrome.

Malays J Pathol 2018 Apr;40(1):33-39

University of Malaya, Faculty of Medicine, Department of Pathology, 50603, Kuala Lumpur, Malaysia.

Introduction: Hyperandrogenism remains as one of the key features in Polycystic Ovarian Syndrome (PCOS) and can be assessed clinically or determined by biochemical assays. Hirsutism is the most common clinical manifestation of hyperandrogenism. The clinical assessment is subjected to wide variability due to poor interobserver agreement and multiple population factors such as ethnic variation, cosmetic procedures and genetic trait. Read More

View Article

Androgen excess and post-reproductive health.

Maturitas 2018 Apr 18. Epub 2018 Apr 18.

Division of Endocrinology and Diabetes, Second Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

View Article

Associations between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes.

Minerva Endocrinol 2018 Apr 12. Epub 2018 Apr 12.

Department of Obstetrics and Gynecology, Section of Reproductive Endocrinology and Infertility, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Background: Studies comparing serum 25-hydroxyvitamin D concentrations in women with and without PCOS have produced inconsistent results. Additionally, no previous studies have evaluated associations between vitamin D and specific PCOS phenotypes.

Methods: This case-control study was conducted among women undergoing intrauterine insemination. Read More

View Article

[Maximal androgen deprivation with abiraterone acetate in hormone sensitive prostate cancer.]

Arch Esp Urol 2018 Mar;71(3):267-275

Servicio de Urología. Hospital Universitario 12 de Octubre. Madrid. España.

Objectives: The treatment of metastatic prostate cancer has remained unchanged for more than 70 years, based on androgen deprivation therapy (ADT). In 2015, following the CHAARTED and STAMPEDE trials, it was established that the addition of 6 cycles of docetaxel to ADT was associated with significantly increased survival. In June 2017, the LATITUDE trial and the G arm of the STAMPEDE trial showed that the addition of Abiraterone with Prednisone (5 mg/day) to ADT was also associated with a significant increase in survival in metastatic patients. Read More

View Article
March 2018
3 Reads

EXOGENOUS TESTOSTERONE DOES NOT INDUCE OR EXACERBATE THE METABOLIC FEATURES ASSOCIATED WITH PCOS AMONG TRANSGENDER MEN.

Endocr Pract 2018 Apr 6. Epub 2018 Apr 6.

Center for Transgender Medicine and Surgery, Mount Sinai Health System and Icahn School of Medicine at Mount Sinai, New York, NY 10128 USA.

Objectives: Polycystic ovarian syndrome (PCOS) is a complex condition which can include menstrual irregularity, metabolic derangement, and increased androgen levels. The mechanism of PCOS is unknown. Some suggest that excess production of androgens by the ovaries may cause or exacerbate the metabolic findings. Read More

View Article

Contemporary approaches to the management of polycystic ovary syndrome.

Authors:
Renato Pasquali

Ther Adv Endocrinol Metab 2018 Apr 7;9(4):123-134. Epub 2018 Feb 7.

University Alma Mater Studiorum of Bologna, Via Santo Stefano 38, 40125 Bologna, Italy.

Polycystic ovary syndrome (PCOS) is a common disorder in women in their reproductive years and is characterized by androgen excess, ovulatory dysfunction, and polycystic ovarian morphology. It is also associated with several metabolic abnormalities, particularly insulin resistance and obesity, which play an important role in the pathophysiology of PCOS and, in particular, negatively influence ovarian function and fertility. This review article summarizes the available treatment for women with PCOS. Read More

View Article
April 2018
1 Read

Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS.

JCI Insight 2018 Apr 5;3(7). Epub 2018 Apr 5.

Androgen excess is a hallmark of polycystic ovary syndrome (PCOS), a prevalent yet poorly understood endocrine disorder. Evidence from women and preclinical animal models suggests that elevated perinatal androgens can elicit PCOS onset in adulthood, implying androgen actions in both PCOS ontogeny and adult pathophysiology. Prenatally androgenized (PNA) mice exhibit a robust increase of progesterone-sensitive GABAergic inputs to gonadotropin-releasing hormone (GnRH) neurons implicated in the pathogenesis of PCOS. Read More

View Article

A Klinefelter boy with congenital adrenal hyperplasia: too much or too little androgens?

Ital J Pediatr 2018 Apr 3;44(1):43. Epub 2018 Apr 3.

Department of Pediatrics, Institute for Maternal and Child Health IRCCS, "Burlo Garofolo", Via dell' Istria 65/1, Trieste, Italy.

Background: The simultaneous occurrence of Klinefelter Syndrome (KS) and Congenital Adrenal Hyperplasia (CAH) is an exceptional event: there are just three case reports (two children and a 51 years old man) describing males affected by both KS and 21OHD (21-hydroxylase deficiency) CAH, the first causing androgen deficiency, the latter leading to androgen excess.

Case Report: We report the 4th case of association of KS and CAH in a young man with CAH with good androgen control and with normal secondary sex characteristics, whose Klinefelter syndrome was diagnosed because of reduced testicular volume. He was the first reported case of association of KS and CAH who started androgen replacement therapy in the pubertal age and whose pubertal development was described and followed up step by step. Read More

View Article
April 2018
2 Reads

Improving Rural Nurse Practitioner Knowledge About Polycystic Ovary Syndrome Through Continuing Education.

J Contin Educ Nurs 2018 Apr;49(4):164-170

Background: Polycystic ovary syndrome (PCOS), a common androgen-excess disorder in reproductive-aged women, is often a missed diagnosis. Rural nurse practitioners (NPs) need to be able to diagnose and provide basic management for PCOS. This study's objective was to determine whether a continuing education program about PCOS would improve NPs' knowledge about PCOS. Read More

View Article
April 2018
1 Read

Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: A longitudinal study based on a United Kingdom primary care database.

PLoS Med 2018 Mar 28;15(3):e1002542. Epub 2018 Mar 28.

Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom.

Background: Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), which affects 10% of women and represents a lifelong metabolic disorder, with increased risk of type 2 diabetes, hypertension, and cardiovascular events. Previous studies have suggested an increased risk of nonalcoholic fatty liver disease (NAFLD) in individuals with PCOS and implicated androgen excess as a potential driver.

Methods And Findings: We carried out a retrospective longitudinal cohort study utilizing a large primary care database in the United Kingdom, evaluating NAFLD rates in 63,120 women with PCOS and 121,064 age-, body mass index (BMI)-, and location-matched control women registered from January 2000 to May 2016. Read More

View Article
March 2018
1 Read

Estrogen: The necessary evil for human health, and ways to tame it.

Biomed Pharmacother 2018 Jun 22;102:403-411. Epub 2018 Mar 22.

Department of Botany, Berhampur University, Berhampur, Odisha, 760007, India.

Estrogen is a pivotal enzyme for survival and health in both genders, though their quantum, tropism, tissue-specific distribution, and receptor affinity varies with different phases of life. Converted from androgen via aromatase enzyme, this hormone is indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular health, fertility, and neural functions. However, estrogen is at the center of almost all human pathologies as well-infectious, autoimmune, metabolic to degenerative. Read More

View Article

Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment.

Nat Rev Endocrinol 2018 May 23;14(5):270-284. Epub 2018 Mar 23.

Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in premenopausal women. Heterogeneous by nature, PCOS is defined by a combination of signs and symptoms of androgen excess and ovarian dysfunction in the absence of other specific diagnoses. The aetiology of this syndrome remains largely unknown, but mounting evidence suggests that PCOS might be a complex multigenic disorder with strong epigenetic and environmental influences, including diet and lifestyle factors. Read More

View Article
May 2018
3 Reads

A Major Population of Functional KLRG1 ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers.

Immunohorizons 2018 Feb;2(2):74-86

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.

Humans show significant sex differences in the incidence and severity of respiratory diseases, including asthma and virus infection. Sex hormones contribute to the female sex bias in type 2 inflammation associated with respiratory diseases, consistent with recent reports that female lungs harbor greater numbers of GATA-3-dependent group 2 innate lymphoid cells (ILC2s). In this study, we determined whether sex hormone levels govern sex differences in the numbers, phenotype, and function of ILC2s in the murine lung and bone marrow (BM). Read More

View Article
February 2018
2 Reads

Maternal androgen excess and obesity induce sexually dimorphic anxiety-like behavior in the offspring.

FASEB J 2018 Mar 22:fj201701263RR. Epub 2018 Mar 22.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Maternal polycystic ovary syndrome (PCOS), a condition associated with hyperandrogenism, is suggested to increase anxiety-like behavior in the offspring. Because PCOS is closely linked to obesity, we investigated the impact of an adverse hormonal or metabolic maternal environment and offspring obesity on anxiety in the offspring. The obese PCOS phenotype was induced by chronic high-fat-high-sucrose (HFHS) consumption together with prenatal dihydrotestosterone exposure in mouse dams. Read More

View Article
March 2018
4 Reads

Dehydroepiandrosterone-induced activation of mTORC1 and inhibition of autophagy contribute to skeletal muscle insulin resistance in a mouse model of polycystic ovary syndrome.

Oncotarget 2018 Feb 12;9(15):11905-11921. Epub 2018 Jan 12.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age and also an important metabolic disorder associated with insulin resistance (IR). Hyperandrogenism is a key feature of PCOS. However, whether hyperandrogenism can cause IR in PCOS remains largely unknown. Read More

View Article
February 2018
4 Reads

Congenital adrenal hyperplasia: clinical symptoms and diagnostic methods.

Acta Biochim Pol 2018 15;65(1):25-33. Epub 2018 Mar 15.

Department of Pediatrics, Pediatric Endocrinology and Diabetes, Medical Faculty, University of Rzeszów, Rzeszów, Poland.

The aim of this paper is a straightforward presentation of the steroidogenesis process and the most common type of congenital adrenal hyperplasia (CAH) - 21-hydroxylase deficiency - as well as the analytical diagnostic methods that are used to recognize this disease. CAH is a family of common autosomal recessive disorders characterized by impaired adrenal cortisol biosynthesis with associated androgen excess due to a deficiency of one or more enzymes in the steroidogenesis process within the adrenal cortex. The most common and prototypical example of the CAH disorders group (90-95%) is caused by 21-hydroxylase deficiency. Read More

View Article
March 2018
4 Reads

Long-term urinary symptoms in adolescent and adult women with congenital adrenal hyperplasia.

J Pediatr Urol 2018 Feb 7. Epub 2018 Feb 7.

Gynaecology Department, Royal Children's Hospital, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia. Electronic address:

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition resulting in excess androgen production. Females are typically born with ambiguous genitalia and often undergo feminising genitoplasty in infancy or childhood. Recently, there has been considerable international debate as to whether distressing urinary symptoms in CAH patients are truly present and, if so, whether these urinary problems are a consequence of the feminising genitoplasty. Read More

View Article
February 2018
2 Reads

An ovarian Leydig cell tumor of ultrasound negative in a postmenopausal woman with hirsutism and hyperandrogenism: A case report.

Medicine (Baltimore) 2018 Mar;97(10):e0093

Department of Endocrinology, the First Affiliated Hospital, College of Medicine, Zhejiang University.

Rationale: The incidence of severe hyperandrogenism associated with masculinity in women is very low. While rare and difficult to diagnose, androgen secreting tumors should be suspected in women with hyperandrogenism and hirsutism, especially in the postmenopausal population. Herein we present one case of ovarian Leydig cell tumor (LCT) with markedly elevated serum testosterone levels and frank hirsutism. Read More

View Article
March 2018
11 Reads

Low digit ratio (2D:4D) and late pubertal onset indicate prenatal hyperandrogenziation in alcohol binge drinking.

Prog Neuropsychopharmacol Biol Psychiatry 2018 Feb 27. Epub 2018 Feb 27.

Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany.

Background: Alcohol binge drinking behavior is an important public health issue. Causal rodent and human associational studies show that reinforcement of prenatal androgen signaling increases alcohol consumption in adulthood. However, the effects of prenatal androgen exposure on adult binge drinking patterns have not been investigated yet. Read More

View Article
February 2018
1 Read

A high-throughput UPC-MS/MS method for the separation and quantification of C and C steroids and their C11-oxy steroid metabolites in the classical, alternative, backdoor and 11OHA4 steroid pathways.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Mar 20;1080:71-81. Epub 2018 Feb 20.

Department of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa. Electronic address:

In the present study an ultra-performance convergence chromatography tandem mass spectrometry (UPC-MS/MS) analytical method was developed and validated for the determination of 17 C and 14 C steroids, including C11-oxy C and C11-oxy C steroids. The limit of detection and limit of quantification ranged from 0.01 to 10 ng/mL and from 0. Read More

View Article
March 2018
6 Reads

Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS.

Endocrinology 2018 Apr;159(4):1734-1747

Department of Reproductive Medicine, Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, California.

Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Although its etiology is unknown, excess androgens are thought to be a critical factor driving the pathology of PCOS. We previously demonstrated that continuous exposure to the aromatase inhibitor letrozole (LET) in mice produces many hallmarks of PCOS, including elevated testosterone (T) and luteinizing hormone, anovulation, and obesity. Read More

View Article
April 2018
5 Reads

Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis.

Gut Microbes 2018 Feb 22:1-22. Epub 2018 Feb 22.

a Department of Physiology and Pharmacology , The University of Toledo College of Medicine and Life Sciences , Toledo , OH.

Background: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Read More

View Article
February 2018
3 Reads

Insulin resistance in an animal model of polycystic ovary disease is aggravated by vitamin D deficiency: Vascular consequences.

Diab Vasc Dis Res 2018 Feb 1:1479164118758580. Epub 2018 Feb 1.

3 Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Hyperandrogenic state in females is accompanied with metabolic syndrome, insulin resistance and vascular pathologies. A total of 67%-85% of hyperandrogenic women suffer also from vitamin D deficiency. We aimed to check a potential interplay between hyperandrogenism and vitamin D deficiency in producing insulin resistance and effects on coronary resistance arteries. Read More

View Article
February 2018
5 Reads

MANAGEMENT OF ENDOCRINE DISEASE Hyperandrogenic states in women: pitfalls in laboratory diagnosis.

Eur J Endocrinol 2018 Apr 16;178(4):R141-R154. Epub 2018 Feb 16.

Laboratoire d'Hormonologied'Endocrinologie Moléculaire et des Maladies Rares, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France.

Measuring total testosterone level is the first-line approach in assessing androgen excess in women. The main pitfalls in measuring testosterone relate to its low concentration and to the structural similarity between circulating androgens and testosterone, requiring accurate techniques with high specificity and sensitivity. These goals can be achieved by immunoassay using a specific anti-testosterone monoclonal antibody, ideally after an extraction step. Read More

View Article
April 2018
2 Reads

The impact of sex steroid agonists and antagonists on folliculogenesis in the neonatal porcine ovary via cell proliferation and apoptosis.

Theriogenology 2018 Jun 10;113:19-26. Epub 2018 Feb 10.

Department of Endocrinology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387, Krakow, Poland. Electronic address:

The objective of the study was to examine the effects of androgen and estrogen agonists or antagonists on the follicle formation, ovarian cell proliferation and apoptosis as well as plasma steroid concentration in neonatal pigs. Piglets were injected with testosterone propionate (TP, 20 mg/kg bw), flutamide (FLU, 50 mg/kg bw), 4-tert-octylphenol (OP, 100 mg/kg bw), ICI 182,780 (ICI, 400 μg/kg bw), methoxychlor (MXC, 100 mg/kg bw) or corn oil (CTR, controls) between postnatal Days 1 and 10 (n = 4/group). Heart blood was collected and ovaries were excised from the 11-day-old piglets. Read More

View Article

Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris.

Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.

Lincoln Memorial University-DeBusk College of Osteopathic Medicine.

The purpose of this literature review is to evaluate the use of metformin as an adjunct therapy in the treatment of moderate-to-severe acne in those not diagnosed with polycystic ovary syndrome (PCOS) or androgen excess. The authors conducted independent literature searches. Results were limited to clinical trials and randomized controlled trials. Read More

View Article
November 2017
1 Read

C1QTNF3 in the murine ovary and its function in folliculogenesis.

Reproduction 2018 Apr 1;155(4):333-346. Epub 2018 Feb 1.

Key Laboratory for Regenerative Medicine (JNU-CUHK)Ministry of Education, Department of Developmental and Regenerative Biology, College of Life Science and Technologies, Jinan University, Guangzhou, China

C1q/tumor necrosis factor-related protein 3 (C1QTNF3) is a novel adipokine with modulating effects on metabolism, inflammation and the cardiovascular system. C1QTNF3 expression levels in the sera and omental adipose tissues of women with PCOS are low compared to control subjects. However, the expression and function of C1QTNF3 in the ovary has not previously been examined. Read More

View Article
April 2018
1 Read
3.17 Impact Factor

Genes and Pathways Regulated by Androgens in Human Neural Cells, Potential Candidates for the Male Excess in Autism Spectrum Disorder.

Biol Psychiatry 2018 Jan 9. Epub 2018 Jan 9.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, UMR 7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France; Laboratory of Genetic Diagnostics, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. Electronic address:

Background: Prenatal exposure to androgens during brain development in male individuals may participate to increase their susceptibility to develop neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability. However, little is known about the action of androgens in human neural cells.

Methods: We used human neural stem cells differentiated from embryonic stem cells to investigate targets of androgens. Read More

View Article
January 2018
6 Reads

Hidradenitis Suppurativa Is Associated with Polycystic Ovary Syndrome: A Population-Based Analysis in the United States.

J Invest Dermatol 2018 Jun 19;138(6):1288-1292. Epub 2018 Feb 19.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York, USA.

Polycystic ovary syndrome (PCOS) has been linked to hidradenitis suppurativa (HS). However, evidence establishing a relationship between the two conditions is limited. We sought to determine the prevalence of PCOS among patients with HS and the strength of the association. Read More

View Article
June 2018
6 Reads

Perimenarchal air pollution exposure and menstrual disorders.

Hum Reprod 2018 Jan 25. Epub 2018 Jan 25.

Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Landmark Center, 401 Park Drive, 3rd F West, Boston, MA 02115, USA.

Study Question: What is the association between perimenarchal exposure to total suspended particulate (TSP) in air, menstrual irregularity phenotypes and time to menstrual cycle regularity?

Summary Answer: Exposures to TSP during high school are associated with slightly increased odds of menstrual irregularity and longer time to regularity in high school and early adulthood.

What Is Known Already: The menstrual cycle is responsive to hormonal regulation. Particulate matter air pollution has demonstrated hormonal activity. Read More

View Article
January 2018
1 Read

Circadian blood pressure profiles and ambulatory arterial stiffness index in children and adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency in relation to their genotypes.

Neuro Endocrinol Lett 2017 Dec;38(7):509-518

Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.

Objective: Lifelong steroid therapy and exposure to adrenal androgen excess in 21-hydroxylase deficient (21-OHD) congenital adrenal hyperplasia (CAH) children and adolescents may modify circadian blood pressure profile and result in vascular complications. The objective of the study was to evaluate vascular abnormalities in 21-OHD children and adolescents in relation to their genotypes.

Design: A cross-sectional study conducted at a tertiary referral center. Read More

View Article
December 2017
14 Reads

New perspectives on the definition and management of polycystic ovary syndrome.

J Endocrinol Invest 2018 Jan 23. Epub 2018 Jan 23.

Unit of Endocrinology, S. Orsola-Malpighi Hospital, University Alma Mater Studiorum of Bologna, Bologna, Italy.

Background: There is a growing debate on the opportunity of improving the understanding in the diagnosis and management of polycystic ovary syndrome (PCOS).

Objective: This review article summarizes recent research related to the definition of polycystic ovary syndrome (PCOS).

Methods: Review of the recent literature on the topic. Read More

View Article
January 2018
2 Reads

Testosterone a key factor in gender related metabolic syndrome.

Obes Rev 2018 Apr 21;19(4):557-575. Epub 2018 Jan 21.

Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.

Metabolic syndrome (MetS) is highly correlated with cardiovascular diseases. Although an excess of body fat is a determinant factor for MetS development, a reduced level of testosterone plays a fundamental role in its regulation. Low testosterone level is highly related to insulin resistance, visceral obesity and MetS. Read More

View Article
April 2018
3 Reads