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Proc Natl Acad Sci U S A 2019 02 13;116(9):3837-3846. Epub 2019 Feb 13.

Departamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain;

Extraocular muscles contain two types of muscle fibers according to their innervation pattern: singly innervated muscle fibers (SIFs), similar to most skeletal muscle fibers, and multiply innervated muscle fibers (MIFs). Morphological studies have revealed that SIF and MIF motoneurons are segregated anatomically and receive different proportions of certain afferents, suggesting that while SIF motoneurons would participate in the whole repertoire of eye movements, MIF motoneurons would contribute only to slow eye movements and fixations. We have tested that proposal by performing single-unit recordings, in alert behaving cats, of electrophysiologically identified MIF and SIF motoneurons in the abducens nucleus. Read More

Biomed Res Int 2019 14;2019:2474273. Epub 2019 Jan 14.

Otorhinolaryngology Surgery Clinic, Institute of Physiology and Pathology of Hearing, Warsaw, Poland.

Background: It is known that cochlear implantation may alter the inner ear and induce vestibular disorders.

Research Question: How does cochlear implantation influence gait stability? . An experimental group of twenty-one subjects scheduled for cochlear implantation underwent gait testing twice, on the day before cochlear implantation (BCI) and three months after cochlear implantation (ACI), using a motion capture system. Read More

Otolaryngol Head Neck Surg 2019 Jan 22:194599818824306. Epub 2019 Jan 22.

2 Department of Otolaryngology-Head & Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Objectives: (1) Describe common patterns of semicircular canal (SCC) anomalies in CHARGE syndrome (CS) and (2) recognize that in CS, the architecture of the superior SCC may be relatively preserved.

Study Design: This is a retrospective review of temporal bone imaging studies.

Setting: Quaternary care center. Read More

Microsc Res Tech 2019 Jan 12. Epub 2019 Jan 12.

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

A thorough understanding of inner ear anatomy is important for investigators. However, investigation of the mouse inner ear is difficult due to the limitations of imaging techniques. X-ray phase contrast tomography increases contrast 100-1,000 times compared with conventional X-ray imaging. Read More

J Anat 2019 Mar 18;234(3):316-326. Epub 2018 Dec 18.

Department of Surgical Sciences, Section of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden.

A thorough knowledge of the gross and micro-anatomy of the human internal acoustic canal (IAC) is essential in vestibular schwannoma removal, cochlear implantation (CI) surgery, vestibular nerve section, and decompression procedures. Here, we analyzed the acoustic-facial cistern of the human IAC, including nerves and anastomoses using synchrotron phase contrast imaging (SR-PCI). A total of 26 fresh human temporal bones underwent SR-PCI. Read More

Handb Clin Neurol 2018 ;159:3-26

Department of Neurology and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, United States. Electronic address:

The review demonstrates that control of posture and locomotion is provided by systems across the caudal-to-rostral extent of the neuraxis. A common feature of the neuroanatomic organization of the postural and locomotor control systems is the presence of key nodes for convergent input of multisensory feedback in conjunction with efferent copies of the motor command. These nodes include the vestibular and reticular nuclei and interneurons in the intermediate zone of the spinal cord (Rexed's laminae VI-VIII). Read More

Handb Clin Neurol 2018 ;159:229-236

Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, University College London, London, United Kingdom. Electronic address:

This chapter presents a review of the literature for falls and abnormalities of balance and gait in isolated dystonia syndromes. Balance appears to be relatively preserved in primary and focal dystonias, except when postural abnormalities significantly displace the center of gravity of the body. Gait can be affected by abnormal dystonic movements and limb deformities, and is commonly abnormal in generalized dystonia. Read More

Pediatr Surg Int 2019 Jan 30;35(1):77-85. Epub 2018 Oct 30.

Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Purpose: Females with recto-vestibular fistula (RVF) can be managed either by one-stage sagittal anorectoplasty (SARP) or by conventional multi-stage approach with colostomy followed by SARP. Our aim was to define which approach, one-stage or multi-stage, is safer and more beneficial.

Methods: Using a defined search strategy, two investigators identified all comparative studies on the mentioned procedures. Read More

Arch Toxicol 2019 Feb 30;93(2):417-434. Epub 2018 Oct 30.

Departament de Ciències Fisiològiques, Institut de Neurociènces, Universitat de Barcelona, Feixa Llarga s/n, 08907, L'Hospitalet de Llobregat, Catalunya, Spain.

The cellular and molecular events that precede hair cell (HC) loss in the vestibular epithelium during chronic ototoxic exposure have not been widely studied. To select a study model, we compared the effects of sub-chronic exposure to different concentrations of 3,3'-iminodipropionitrile (IDPN) in the drinking water of two strains of mice and of both sexes. In subsequent experiments, male 129S1/SvImJ mice were exposed to 30 mM IDPN for 5 or 8 weeks; animals were euthanized at the end of the exposure or after a washout period of 13 weeks. Read More

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418808680

1 Audiology and ENT Clinic, University of Ferrara, Ferrara, Italy.

Autoimmune inner ear disease (AIED) has been defined as a condition of bilateral sensorineural hearing loss (SNHL), caused by an 'uncontrolled' immune system response. The inner ear can be the direct target of the immune response, but it can be additionally damaged by a deposition of circulating immune complexes or by systemic immune-mediated diseases. The clinical expression of immune-mediated inner ear disease shows a progressive bilateral and asymmetric SNHL profile, which typically benefits from a steroid and immunosuppressive therapy. Read More

Neuroscience 2018 12 24;394:177-188. Epub 2018 Oct 24.

Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98., Debrecen H-4032, Hungary; MTA-DE Neuroscience Research Group, Nagyerdei krt. 98., Debrecen 4032, Hungary. Electronic address:

Previously we described similarities and differences in the organization and molecular composition of an aggrecan based extracellular matrix (ECM) in three precerebellar nuclei, the inferior olive, the prepositus hypoglossi nucleus and the red nucleus of the rat associated with their specific cytoarchitecture, connection and function in the vestibular system. The aim of present study is to map the ECM pattern in a mesencephalic precerebellar nucleus, the pararubral area, which has a unique function among the precerebellar nuclei with its retinal connection and involvement in the circadian rhythm regulation. Using histochemistry and immunohistochemistry we have described for the first time the presence of major ECM components, the hyaluronan, aggrecan, versican, neurocan, brevican, tenascin-R (TN-R), and the HAPLN1 link protein in the pararubral area. Read More

Cerebellum 2018 Dec;17(6):699-700

Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan.

Cerebellar Purkinje neurons are arguably some of the most conspicuous neurons in the vertebrate central nervous system. They have characteristic planar fan-shaped dendrites which branch extensively and fill spaces almost completely with little overlap. This dendritic morphology is well suited to receiving a single or a few excitatory synaptic inputs from each of more than 100,000 parallel fibers which run orthogonally to Purkinje cell dendritic trees. Read More

J Biophotonics 2019 Feb 31;12(2):e201800209. Epub 2018 Oct 31.

Graduate Program in Dentistry, Universidade Federal de Pernambuco, Recife, Brazil.

Optical coherence tomography (OCT) is one of the most important imaging modalities for biophotonics applications. In this work, an important step towards the clinical use of OCT in dental practice is reported, by following-up patients treated from periodontal disease (PD). A total of 147 vestibular dental sites from 14 patients diagnosed with PD were evaluated prior and after treatment, using a swept-source OCT and two periodontal probes (Florida probe and North Carolina) for comparison. Read More

J Neurooncol 2018 Dec 20;140(3):679-686. Epub 2018 Sep 20.

Department of Otology and Skull Base Surgery, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai, People's Republic of China.

Purpose: To investigate the relationship between vestibular schwannoma (VS) size and the dysfunction and compensation of the vestibular system.

Methods: One hundred fifty-two patients with unilateral VS were investigated using multiple auditory-vestibular function tests such as audiometry, sensory organization test (SOT), caloric test, cervical vestibular-evoked myogenic potential (cVEMP) test, and ocular VEMP (oVEMP) test.

Results: In this study, 89% of patients with unilateral VS had mild to severe hearing loss on the involved side. Read More

eNeuro 2018 Jul-Aug;5(4). Epub 2018 Aug 30.

Department of Integrative Physiology and Neuroscience, Washington State University, Vancouver, WA 98686.

Excessive noise exposure damages sensory hair cells, leading to permanent hearing loss. Zebrafish are a highly tractable model that have advanced our understanding of drug-induced hair cell death, yet no comparable model exists for noise exposure research. We demonstrate the utility of zebrafish as model to increase understanding of hair cell damage from acoustic trauma and develop protective therapies. Read More

J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2018 Oct 11;204(9-10):835-847. Epub 2018 Sep 11.

Department of Pharmacology and Toxicology, School of Biomedical Sciences and Brain Health Research Centre, University of Otago, Dunedin, New Zealand.

Rats are the most commonly used species in the neurosciences; however, little is known about the effects of selective electrical stimulation of individual vestibular sensors, on their eye movements. This limits their use to study the effects of vestibular stimulation on the brain, and their use in further exploring novel technologies such as artificial vestibular implants. We describe the effects of electrical stimulation of each vestibular sensor on vestibular-related eye movement in rats and compared the results to other species. Read More

Ups J Med Sci 2018 Sep 11;123(3):131-142. Epub 2018 Sep 11.

a Department of Surgical Sciences , Section of Otolaryngology, Uppsala University Hospital , Uppsala , Sweden.

Background: The Uppsala collection of human temporal bones and molds is a unique resource for education and international research collaboration. Micro-computerized tomography (micro-CT) and synchrotron imaging are used to investigate the complex anatomy of the inner ear. Impaired microcirculation is etiologically linked to various inner ear disorders, and recent developments in inner ear surgery promote examination of the vascular system. Read More

J Morphol 2018 Aug 17. Epub 2018 Aug 17.

Rheinische Friedrich-Wilhelms-Universität Bonn, Steinmann Institut für Geologie, Mineralogie und Paläontologie, Bonn, Germany.

The evolution of the various hearing adaptations is connected to major structural changes in nearly all groups of vertebrates. Besides hearing, the detection of acceleration and orientation in space are key functions of this mechanosensory system. The symposium "show me your ear - the inner and middle ear in vertebrates" held at the 11th International Congress of Vertebrate Morphology (ICVM) 2016 in Washington, DC (USA) intended to present current research addressing adaptation and evolution of the vertebrate otic region, auditory ossicles, vestibular system, and hearing physiology. Read More

Results Probl Cell Differ 2018 ;65:585-598

Department of Biology, University of Napoli Federico II, Napoli, Italy.

Octopus vulgaris underwent a radical modification to cope with the benthic lifestyle. It diverged from other cephalopods in terms of body plan, anatomy, behavior, and intelligence. It independently evolved the largest and most complex nervous system and sophisticated behaviors among invertebrates in a separate evolutionary lineage. Read More

PLoS One 2018 31;13(7):e0198155. Epub 2018 Jul 31.

White Mountain Dinosaur Exploration Center, Springerville, Arizona, United States of America.

The soft-tissue reconstruction and associated osteology of the North American therizinosaurian Nothronychus mckinleyi is updated. The cranial nerve topology is revised, bringing it more in line with coelurosaurs. The trunk of the trigeminal nerve is very short, with an incompletely intracranial trigeminal ganglion, an ophthalmic branch diverging anteriorly first, with later divergences of the maxillomandibular branches, following typical pathways. Read More

Aerosp Med Hum Perform 2018 Aug;89(8):744-748

Introduction: Orientation in a 3-dimensional environment increases demands on the vestibular system. The anterior, lateral, and posterior semicircular canals sense pitch, roll, and yaw acceleration, respectively. The macular end organs sense linear acceleration and provide gravity reference. Read More

Exp Brain Res 2018 Oct 17;236(10):2739-2750. Epub 2018 Jul 17.

Center for Neuroscience and Regenerative Medicine, Henry Jackson Foundation, Bethesda, MD, USA.

Dizziness, postural instability, and ataxia are among the most debilitating symptoms of multiple sclerosis (MS), reflecting, in large part, dysfunctional integration of visual, somatosensory, and vestibular sensory cues. However, the role of MS-related supratentorial lesions in producing such symptoms is poorly understood. In this study, motor control test (MCT) and dynamic sensory organization test (SOT) scores of 58 MS patients were compared to those of 72 healthy controls; correlations were determined between the MS scores of 49 patients and lesion volumes within 26 brain regions. Read More

Physiol Rep 2018 Jul;6(13):e13791

Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.

Connections between the vestibular system and the basal ganglia have been postulated since the early 20th century. However, the results of electrophysiological studies investigating neuronal responses to electrical stimulation of the vestibular system have been inconsistent. The aim of this study was to investigate the effects of electrical stimulation of the vestibular labyrinth on single neuron activity and c-Fos expression in the rat striatum. Read More

Exp Brain Res 2018 Oct 2;236(10):2619-2626. Epub 2018 Jul 2.

School of Medicine, Western Sydney University, Sydney, Australia.

We tested the hypothesis that random variations in the magnitude of sinusoidal linear acceleration cause greater modulation of skin sympathetic nerve activity (SSNA), but not muscle sympathetic nerve activity (MSNA), than sinusoidal stimuli of the same frequency but constant amplitude. Subjects (n = 22) were seated in a sealed room mounted on a linear motor that could deliver peak sinusoidal accelerations of 30 mG in the antero-posterior direction. Subjects sat on a padded chair with their neck and head supported vertically, thereby minimizing somatosensory cues, facing the direction of motion in the anterior direction. Read More

Neurochem Res 2018 Aug 13;43(8):1587-1598. Epub 2018 Jun 13.

Department of Anatomy, National University of Singapore, Singapore, 119260, Singapore.

Arachidonic acid and docosahexaenoic acid (DHA) released by the action of phospholipases A (PLA) on membrane phospholipids may be metabolized by lipoxygenases to the anti-inflammatory mediators lipoxin A4 (LXA4) and resolvin D1 (RvD1), and these can bind to a common receptor, formyl-peptide receptor 2 (FPR2). The contribution of this receptor to axonal or dendritic outgrowth is unknown. The present study was carried out to elucidate the distribution of FPR2 in the rat CNS and its role in outgrowth of neuronal processes. Read More

World Neurosurg 2018 Sep 19;117:221-224. Epub 2018 Jun 19.

Department of Neuro-Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

Background: Anaplastic gangliogliomas at the cerebellopontine angle (CPA) are exceptionally rare with only a few reported cases in published literature. These are composed of atypical ganglion cells and astrocytes accounting for nearly 1% of all central nervous system tumors. The authors report the case of anaplastic ganglioglioma in an adult patient presenting as a CPA mass lesion. Read More

Mol Pain 2018 Jan-Dec;14:1744806918783457. Epub 2018 Jun 19.

2 Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Acupuncture at pericardium 6 (PC6) shows a consistently positive efficacy in nausea response suggested by consensus expert guidelines. Nausea encompasses aversive symptom as well as strong emotional components. Disgust is a subjective emotion of uneasy commonly accompanying with a physiological response that is accompanied by strong visceral sensations (e. Read More

PLoS One 2018 30;13(5):e0197079. Epub 2018 May 30.

Northwestern University, Chicago, Illinois, United States of America.

Objective: Our aim was to determine whether overt catch up saccades (OS) provoked by vestibular stimuli, as observed in the video head impulse test (vHIT), have comparable metrics as visually triggered horizontal saccades (VS), indicating a common saccadic brainstem generator.

Methods: Three groups of patients were studied: patients with neurological disorders causing slow saccades (group 1, n = 12), patients with peripheral vestibular lesions (group 2, n = 43), and normal controls (group 3, = 24). All patients underwent vHIT and Videooculographic testing. Read More

Acta Vet Scand 2018 May 22;60(1):31. Epub 2018 May 22.

Department of Diagnostic Medicine/Pathobiology, Kansas State Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, K-221 Mosier Hall, Manhattan, KS, 66506-5802, USA.

Background: An aural cholesteatoma, more appropriately named tympanokeratoma, is an epidermoid cyst of the middle ear described in several species, including dogs, humans and Mongolian gerbils. The cyst lining consists of stratified, keratinizing squamous epithelium with central accumulation of a keratin debris. This case report describes vestibular ganglioneuritis and perineuritis in a dog with chronic otitis, bilateral tympanokeratomas and presumed extension of otic infection to the central nervous system. Read More

Phys Rev E 2018 Apr;97(4-1):042411

Department of Physics, University of California, Los Angeles, California, USA and Department of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.

The amphibian sacculus (AS) is an end organ that specializes in the detection of low-frequency auditory and vestibular signals. In this paper, we propose a model for the AS in the form of an array of phase oscillators with long-range coupling, subject to a steady load that suppresses spontaneous oscillations. The array is exposed to significant levels of frequency dispersion and intrinsic noise. Read More

Anat Rec (Hoboken) 2019 Mar 7;302(3):472-484. Epub 2018 May 7.

Department of Human Anatomy and Psychobiology and IMIB-Arrixaca Institute, School of Medicine, University of Murcia, Murcia, E30071, Spain.

Use of a segmental approach in the study of vestibular centers in the hindbrain improves morphological and functional understanding of this region controlled by Hox genes, among other molecular determinants. Here, we review accrued data about segmental organization of vestibular afferents and efferents. Inner ear-originated vestibular fibers enter the hindbrain, together with auditory ones, through the alar plate of rhombomere 4, then branch into descending and ascending branches to reach appropriate vestibular nuclei along the vestibular column. Read More

Neurosci Lett 2018 06 22;677:60-64. Epub 2018 Apr 22.

Dept. of Pharmacology and Toxicology, School of Biomedical Sciences and Brain Health Research Centre, University of Otago, Dunedin, New Zealand; Brain Research New Zealand Centre of Research Excellence, New Zealand; Eisdell Moore Centre for Hearing and Balance Research, University of Auckland, New Zealand. Electronic address:

Several studies have demonstrated that electrical activation of the peripheral vestibular system can evoke field potential, multi-unit neuronal activity and acetylcholine release in the hippocampus (HPC). However, no study to date has employed the immediate early gene protein, c-Fos, to investigate the distribution of activation of cells in the HPC following electrical stimulation of the vestibular system. We found that vestibular stimulation increased the number of animals expressing c-Fos in the dorsal HPC compared to sham control rats (P ≤ 0. Read More

Anat Rec (Hoboken) 2019 Mar 4;302(3):463-471. Epub 2018 May 4.

Laboratory of Neurobiology of Hearing, Dept. of Immunology, Ophthalmology and Otorhinolaryngology, Faculty of Medicine, Complutense University of Madrid (Spain).

The VIII nerve is formed by sensory neurons that innervate the inner ear, i.e., the vestibular and the auditory receptors. Read More

Anat Histol Embryol 2018 Aug 26;47(4):322-329. Epub 2018 Mar 26.

Department of Veterinary Sciences, University of Messina, Messina, Italy.

The mechanosensory lateral line system of fish is responsible for several functions such as balance, hearing, and orientation in water flow and is formed by neuromast receptor organs distributed on head, trunk and tail. Superficial and canal neuromasts can be distinguished for localization and morphological differences. Several information is present regarding the superficial neuromasts of zebrafish and other teleosts especially during larval and juvenile stages, while not as numerous data are so far available about the ultrastructural characteristics of the canal neuromasts in adult zebrafish. Read More

Front Neurosci 2018 26;12:107. Epub 2018 Feb 26.

Department of Otolaryngology, Medical University of Innsbruck, Innsbruck, Austria.

Stable posture and body movement in humans is dictated by the precise functioning of the ampulla organs in the semi-circular canals. Statistical analysis of the interrelationship between bony and membranous compartments within the semi-circular canals is dependent on the visualization of soft tissue structures. Thirty-one human inner ears were prepared, post-fixed with osmium tetroxide and decalcified for soft tissue contrast enhancement. Read More

Handb Clin Neurol 2018 ;151:119-140

German Center for Vertigo and Balance Disorders-IFB, Ludwig-Maximilians-University, Munich, Germany; Clinical Neuroscience, Ludwig-Maximilians-University, Munich, Germany.

The vestibular cortex differs in various ways from other sensory cortices. It consists of a network of several distinct and separate temporoparietal areas. Its core region, the parietoinsular vestibular cortex (PIVC), is located in the posterior insula and retroinsular region and includes the parietal operculum. Read More

Zoology (Jena) 2018 04 29;127:114-120. Epub 2017 Nov 29.

Laboratory of Functional Morphology, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Movement and Sport Sciences, Ghent University, Watersportlaan 2, 9000 Ghent, Belgium.

The cyclic patterns of terrestrial animal locomotion are frequently perturbed in natural environments. The terrain can be complex or inclined, the substrate can move unexpectedly and animals can misjudge situations. Loosing stability due to perturbations increases the probability of capture by predators and decreases the chance of successful prey capture and winning intraspecific battles. Read More

Sci Rep 2018 02 2;8(1):2301. Epub 2018 Feb 2.

Division of Paleontology, American Museum of Natural History, Central Park West at 79th Street, New York, NY, 10024, USA.

The cheetah, Acinonyx jubatus, is the fastest living land mammal. Because of its specialized hunting strategy, this species evolved a series of specialized morphological and functional body features to increase its exceptional predatory performance during high-speed hunting. Using high-resolution X-ray computed micro-tomography (μCT), we provide the first analyses of the size and shape of the vestibular system of the inner ear in cats, an organ essential for maintaining body balance and adapting head posture and gaze direction during movement in most vertebrates. Read More

Dement Geriatr Cogn Disord 2017 26;44(5-6):294-302. Epub 2018 Jan 26.

Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background/aims: Patients with Alzheimer's disease (AD) experience increased rates of vestibular loss. Recent studies suggest that saccular impairment in mild cognitive impairment (MCI) and AD patients is associated with impaired spatial cognitive function. However, the impact of saccular impairment on everyday behaviors that rely on spatial cognitive function is unknown. Read More

World Neurosurg 2018 Apr 8;112:18-24. Epub 2018 Jan 8.

Skull Base Surgery Unit, Department of Neurosurgery B, University Hospital of Lyon, Hospices Civils de Lyon, Lyon, France; CREATIS Laboratory, CNRS UMR5220, INSERM U1206, Lyon 1 University, INSA, Lyon, France. Electronic address:

Background: Liponeurocytoma is a very rare tumor classified as grade II (neuronal and mixed neuronal-glial tumors) according to 2016 World Health Organization classification of tumors of the central nervous system. The median age at detection is 50 years, and the most frequent location is the posterior cranial fossa, especially within the cerebellar hemispheres; liponeurocytomas arising in the cerebellopontine angle (CPA) are exceptional.

Case Description: Here we report the clinical, radiological, and pathological characteristics of a CPA liponeurocytoma in a 35-year-old woman, as well as a review of the literature. Read More

Eur J Neurol 2018 04 26;25(4):659-665. Epub 2018 Feb 26.

Auckland District Health Board, Auckland.

Background And Purpose: Sensory neuronopathy is a cardinal feature of cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS). Having observed that two patients with CANVAS had small median and ulnar nerves on ultrasound, we set out to examine this finding systematically in a cohort of patients with CANVAS, and compare them with both healthy controls and a cohort of patients with axonal neuropathy. We have previously reported preliminary findings in seven of these patients with CANVAS and seven healthy controls. Read More

Front Neurosci 2017 19;11:713. Epub 2017 Dec 19.

Department for Biomedical Computer Science and Mechatronics, Institute of Electrical and Biomedical Engineering, University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria.

Our sense of balance and spatial orientation strongly depends on the correct functionality of our vestibular system. Vestibular dysfunction can lead to blurred vision and impaired balance and spatial orientation, causing a significant decrease in quality of life. Recent studies have shown that vestibular implants offer a possible treatment for patients with vestibular dysfunction. Read More

Eur J Med Genet 2018 Jun 4;61(6):341-347. Epub 2018 Jan 4.

Department of Otorhinolaryngology, Reference Centre on Lysosomal Storage Disorders, Hospital Senhora da Oliveira, Guimarães, Portugal.

Background: Fabry disease (FD) is a lysosomal storage disorder (LSD) that involves the cochleovestibular system. Tinnitus and progressive sensorineural hearing loss are frequent complains. A stabilization of hearing function has been reported with enzyme replacement therapy (ERT). Read More

Turk J Med Sci 2017 Dec 19;47(6):1903-1911. Epub 2017 Dec 19.

Background/aim: Isolated cell cultures are widely used to study neuronal properties due to their advantages. Although embryonic animals are preferred for culturing, their morphological or electrophysiological properties may not reflect adult neurons, which may be important in neurodegenerative diseases. This paper aims to develop a method for preparing isolated cell cultures of medial vestibular nucleus (MVN) from adult mice and describe its morphological and electrophysiological properties. Read More

PLoS One 2018 5;13(1):e0190596. Epub 2018 Jan 5.

Department of Neurosurgery, Xi'an Jiaotong University School of Medicine, Xi'an, People's Republic of China.

Although many mathematical methods were used to analyze the neural activity under sinusoidal stimulation within linear response range in vestibular system, the reliabilities of these methods are still not reported, especially in nonlinear response range. Here we chose nonlinear least-squares algorithm (NLSA) with sinusoidal model to analyze the neural response of semicircular canal neurons (SCNs) during sinusoidal rotational stimulation (SRS) over a nonlinear response range. Our aim was to acquire a reliable mathematical method for data analysis under SRS in vestibular system. Read More

Acta Odontol Scand 2018 May 4;76(4):247-252. Epub 2017 Dec 4.

e Department of Oral and Maxillofacial Radiology, Faculty of Dentistry , Akdeniz University , Antalya , Turkey.

Objective: This study evaluated the prevalence and morphological characteristics of the superior semicircular canal (SSCC) in cleft lip and palate (CL/P) patients using cone beam computed tomography (CBCT).

Materials And Methods: CBCT images of 53 CL/P patients (28 males and 25 females) and a control group of 76 patients (42 males and 34 females) were evaluated. Retrospectively, 258 temporal bone images from 129 patients were evaluated in terms of SSCC morphology and divided into a normal pattern (0. Read More

Cochlear Implants Int 2018 05 30;19(3):170-179. Epub 2017 Nov 30.

c Department of Medical Imaging (RJR) , St. Peter's Hospital , 315 South Manning Blvd, Albany , NY , USA.

Objective And Importance: To describe cases that illustrate the utility of intraoperative computed tomography (CT) in cochlear implantation of patients with difficult temporal bone anatomy.

Clinical Presentation: A 2-year-old male with congenital X-linked stapes gusher syndrome and a 2-year-old female with enlarged vestibular aqueduct underwent successful cochlear implantation with the help of intraoperative CT. In the latter case, the initial intraoperative C-arm fluoroscopy suggested malposition of the electrode, however, was not able to provide details for adjustments. Read More

J Anat 2017 Dec;231(6):990-1018

Department of Natural Sciences, National Museums Scotland, Edinburgh, UK.

The bony labyrinth of vertebrates houses the semicircular canals. These sense rotational accelerations of the head and play an essential role in gaze stabilisation during locomotion. The sizes and shapes of the semicircular canals have hypothesised relationships to agility and locomotory modes in many groups, including birds, and a burgeoning palaeontological literature seeks to make ecological interpretations from the morphology of the labyrinth in extinct species. Read More

Paediatr Anaesth 2018 Jan 17;28(1):13-22. Epub 2017 Nov 17.

Harvard Medical School, MassGeneral Hospital for Children, The Massachusetts General Hospital, Boston, MA, USA.

Background: There is disagreement regarding the anatomy of the pediatric airway, particularly regarding the shape of the cricoid cartilage and the location of the narrowest portion of the larynx.

Aims: The aim of this review is to clarify the origin and the science behind these differing views.

Methods: We undertook a review of published literature, University Libraries, and authoritative textbooks with key search words and phrases. Read More

Mamm Genome 2018 04 24;29(3-4):229-244. Epub 2017 Oct 24.

CHU Sainte-Justine Research Center, Montréal, QC, Canada.

Planar cell polarity (PCP) signaling controls a number of morphogenetic processes including convergent extension during gastrulation and neural tube formation. Defects in this pathway cause neural tube defects (NTD), the most common malformations of the central nervous system. The Looptail (Lp) mutant mouse was the first mammalian mutant implicating a PCP gene (Vangl2) in the pathogenesis of NTD. Read More