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    Origin, Branching, and Communications of the Intercostobrachial Nerve: a Meta-Analysis with Implications for Mastectomy and Axillary Lymph Node Dissection in Breast Cancer.
    Cureus 2017 Mar 17;9(3):e1101. Epub 2017 Mar 17.
    Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
    The intercostobrachial nerve (ICBN), which usually originates from the lateral cutaneous branch of the second intercostal nerve, innervates areas of the axilla, lateral chest, and medial arm. It is at risk for injury during operative procedures that are often used in the management of breast cancer and such injury has been associated with postoperative sensory loss and neuropathic pain, decreasing the quality of life. PubMed, Excerpta Medica Database (EMBASE), ScienceDirect, Google Scholar, China National Knowledge Infrastructure (CNKI), Scientific Electronic Library Online (SciELO), Biosciences Information Service (BIOSIS), and Web of Science were searched comprehensively. Read More

    Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.
    PLoS One 2017 19;12(4):e0175755. Epub 2017 Apr 19.
    The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Australia.
    Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Read More

    Droplet digital PCR (ddPCR) vs quantitative real-time PCR (qPCR) approach for detection and quantification of Merkel cell polyomavirus (MCPyV) DNA in formalin fixed paraffin embedded (FFPE) cutaneous biopsies.
    J Virol Methods 2017 Apr 14. Epub 2017 Apr 14.
    Department of Experimental and Clinical Medicine, University of Florence, Italy. Electronic address:
    Background: Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma and high viral load in the skin was proposed as a risk factor for the occurrence of this tumour. MCPyV DNA was detected, with lower frequency, in different skin cancers but since the viral load was usually low, the real prevalence of viral DNA could be underestimated.

    Objective: To evaluate the performance of two assays (qPCR and ddPCR) for MCPyV detection and quantification in formalin fixed paraffin embedded (FFPE) tissue samples. Read More

    Malignant Melanoma in African-Americans: A Population-Based Clinical Outcomes Study Involving 1106 African-American Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1988-2011).
    Medicine (Baltimore) 2017 Apr;96(15):e6258
    aDepartment of Surgery, Saint Barnabas Medical Center, Livingston, NJ bSaint George's University School of Medicine, Grenada, West Indies cDepartment of Surgery, New Jersey Medical School, Rutgers University, Newark, NJ dDepartment of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ.
    Malignant melanoma accounts for 75% of all skin cancer deaths and is potentially curable if identified early. Although melanoma is rare in African-Americans (AA), it is associated with a worse prognosis than in Caucasians. This study examines the demographic, pathologic, and clinical factors impacting AA melanoma outcomes. Read More

    Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration.
    Aesthet Surg J 2017 May;37(suppl_1):S20-S31
    Dr Nestor is a Voluntary Associate Professor, Department of Dermatology and Cutaneous Surgery, Department of Surgery, Division of Plastic Surgery, University of Miami Leonard Miller School of Medicine, Miami, FL. Dr Ablon is an Associate Clinical Professor of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA. Dr Pickett is Director and Founder of Toxin Science Limited, Wrexham, UK; and an Adjunct Professor at the Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA.
    Time to onset of response and duration of response are key measures of botulinum toxin efficacy that have a considerable influence on patient satisfaction with aesthetic treatment. However, there is no overall accepted definition of efficacy for aesthetic uses of botulinumtoxinA (BoNT-A). Mechanical methods of assessment do not lend themselves to clinical practice and clinicians rely instead on assessment scales such as the Frontalis Activity Measurement Standard, Frontalis Rating Scale, Wrinkle Severity Scale, and Subject Global Assessment Scale, but not all of these have been fully validated. Read More

    Sustained attractiveness and natural youthful appearance by upper lip rejuvenation : Minimally invasive procedures to combat facial aging.
    Wien Med Wochenschr 2017 Apr 5. Epub 2017 Apr 5.
    Clinica Goldman, Porto Alegre/RS, Brazil.
    Facial aging is a complex process individualized by interaction with exogenous and endogenous factors. The upper lip is one of the facial components by which facial attractiveness is defined. Upper lip aging is significantly influenced by maxillary bone and teeth. Read More

    Relevant Insertion Site Anatomy of the Conventus Distal Radius System.
    Hand (N Y) 2017 Mar 1:1558944717701239. Epub 2017 Mar 1.
    1 Valley Orthopedic Surgery Residency, Modesto, CA, USA.
    Background: The Conventus Distal Radius System (DRS) is an intramedullary fixation scaffold inserted into the lateral aspect of the distal radius. The purpose of this study was to identify insertion site anatomy to illustrate risks associated with the minimally invasive nature of radial-sided implant application.

    Methods: Ten cadavers were utilized. Read More

    The Relationship of Superficial Cutaneous Nerves and Interperforator Connections in the Leg: A Cadaveric Anatomical Study.
    Plast Reconstr Surg 2017 Apr;139(4):994e-1002e
    Melbourne, Victoria, Australia From the Jack Brockhoff Reconstructive Plastic Surgery Research Unit (Taylor Lab), Department of Anatomy and Neurosciences, University of Melbourne.
    Background: The lower limb is a source of many flaps both for closure of local defects and for free transfer. Fasciocutaneous flap techniques have been progressively refined, although the vascular basis for their success needs clarification.

    Methods: Archival studies of 48 lower limbs were reviewed and combined with 20 studies of lower limbs from fresh cadavers, making a total of 68 investigations. Read More

    Reporting of mitotic rate in cutaneous melanoma: A study using the national cancer data base.
    J Surg Oncol 2017 Mar;115(3):281-286
    Department of Surgery, Carolinas Medical Center, Levine Cancer Institute, Charlotte, North Carolina.
    Background: The seventh edition of the American Joint Commission on Cancer staging manual (AJCC7, published 2009), updated thin cutaneous melanoma staging protocols with the incorporation of mitotic rate (MR). In these patients, higher MR is associated with decreased survival. This study utilizes the National Cancer Data Base (NCDB) to evaluate MR reporting since AJCC7. Read More

    The role of imaging in the management of patients with nonmelanoma skin cancer: When is imaging necessary?
    J Am Acad Dermatol 2017 Apr;76(4):591-607
    Department of Dermatology, MD Anderson Cancer Center, Houston, Texas.
    When treating aggressive skin cancers, pre- and postoperative imaging provides important information for treatment planning and multidisciplinary cooperation of care. It is important for dermatologists to recognize the clinical scenarios where imaging is indicated in the management of skin cancer. We here address the most common indications for imaging in cutaneous oncology and how to best utilize the modalities available. Read More

    Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma.
    Am J Pathol 2017 May 17;187(5):1186-1197. Epub 2017 Mar 17.
    Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland. Electronic address:
    Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8) and normal human epidermal keratinocytes (n = 11) with real-time quantitative PCR and Western blotting revealed up-regulation of C3 and CFB expression in cSCC cells. Read More

    Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis.
    Int J Mol Sci 2017 Mar 10;18(3). Epub 2017 Mar 10.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo 113-8603, Japan.
    Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. Read More

    A 92-year-old man with primary cutaneous diffuse large B-cell non-Hodgkin's lymphoma manifesting as a giant scalp mass: A case report.
    Medicine (Baltimore) 2017 Mar;96(10):e6270
    Department of Neurosurgery, XinHua Hospital affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China.
    Rationale: Primary cutaneous non-Hodgkin's lymphoma (NHL) is an uncommon entity, representing 10% of all extranodal NHLs. Among all cutaneous sites, the scalp is a rare site of representation.

    Patient Concerns: A 92-year-old Chinese man visited our hospital with a multiple-nodular huge scalp mass on the right parieto-occipital regions. Read More

    Bimatoprost for the treatment of eyelash, eyebrow and scalp alopecia.
    Expert Opin Investig Drugs 2017 Apr 16;26(4):515-522. Epub 2017 Mar 16.
    b Department of Dermatology and Cutaneous Surgery , University of Miami, Miller School of Medicine , Miami , FL , USA.
    Introduction: Alopecia is a common condition observed among people of all ages. It is a disorder that can involve only the scalp as observed in androgenetic alopecia or scalp and body as in alopecia areata or patients under chemotherapy treatment. There are several treatment options with different safety and efficacy outcomes. Read More

    Expression of Programmed Cell Death Ligand in Cutaneous Squamous Cell Carcinoma and Treatment of Locally Advanced Disease With Pembrolizumab.
    JAMA Dermatol 2017 Apr;153(4):299-303
    Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York.
    Importance: Limited therapies are available in patients with inoperable locally advanced cutaneous squamous cell carcinoma (cSCC).

    Objective: To determine the efficacy of programmed cell death 1 receptor (PD-1) inhibitors in locally advanced cSCC.

    Design, Setting, And Participants: A single patient with locally advanced cSCC who declined surgery and radiotherapy underwent treatment with pembrolizumab, an anti-PD-1 antibody, at an academic dermatologic surgery section and cancer center. Read More

    Association of Oncogenic Mutations in Patients With Advanced Cutaneous Squamous Cell Carcinomas Treated With Cetuximab.
    JAMA Dermatol 2017 Apr;153(4):291-298
    Department of Dermatology, University Hospital of Nice, France.
    Importance: Cetuximab was recently proposed for advanced cutaneous squamous cell carcinomas (cSCC); however, its efficacy is inconsistent and identification of predictive biomarkers for response is necessary.

    Objective: To search for somatic mutations of the HRAS, KRAS, NRAS, BRAF, and EGFR genes in patients with advanced cSCC treated with cetuximab; and to investigate the efficacy and tolerance of cetuximab according to these mutations.

    Design, Setting, And Participants: A multicentric and retrospective study of 31 patients (22 men, 9 women) with histologically confirmed advanced cSCC carried out in 1 department of dermatology and 2 departments of medical oncology in France between January 2008 and December 2014. Read More

    Ocular Adnexal Reconstruction for Cutaneous Periocular Malignancies.
    Semin Plast Surg 2017 Feb;31(1):22-30
    Oculoplastic and Orbital Surgery, Morgenstern Center for Orbital and Facial Plastic Surgery, Wayne, Pennsylvania.
    Although the majority of lesions present in the periocular region are benign, periocular cutaneous malignancies are certainly not uncommon and must be considered. The management of nonmelanoma cutaneous malignancies is predominately surgical with Mohs micrographic surgery or excision with frozen sections. The approach to reconstruction of the resulting defects depends on the defect location and size. Read More

    Locally advanced colon cancer with cutaneous invasion: case report.
    BMC Res Notes 2017 Mar 1;10(1):113. Epub 2017 Mar 1.
    Department of General Surgery, Centro Hospitalar Trás-os-Montes e Alto Douro, Avenida da Noruega, Lordelo, 5000-508, Vila Real, Portugal.
    Background: Locally advanced colon cancer with direct abdominal wall and skin invasion is an extremely rare finding with most data being derived from case reports, historical autopsy-based or single-center retrospective studies. We present a unique case of a colon cancer with direct cutaneous invasion and colocutaneous fistulization.

    Case Presentation: Eighty-six year old Caucasian female with multiple comorbidities, referred to Surgical Consultation due to ulcerated skin lesion in the abdomen. Read More

    miR-155 promotes cutaneous wound healing through enhanced keratinocytes migration by MMP-2.
    J Mol Histol 2017 Apr 28;48(2):147-155. Epub 2017 Feb 28.
    Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an, 710032, Shaanxi, China.
    Inflammation, re-epithelization and tissue remodeling are three essential steps during wound healing. The re-epithelization process plays the most important role which mainly involves keratinocyte proliferation and migration. miR-155 has been reported to participate in cell migration and transformation, however, its function in skin wound healing is largely unknown. Read More

    Rare association of congenital penile urethrocutaneous fistula with Y-type urethral duplication.
    BMJ Case Rep 2017 Feb 24;2017. Epub 2017 Feb 24.
    Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.
    A 24-year-old man presented with symptoms of difficulty in passage of urine, mixed with gas and stool from penoscrotal junction since birth. He had a history of surgery (posterior sagittal anorectoplasty) for imperforate anus in first week of his life. On physical examination, external meatus was adequate with small 5×5 mm fistulous opening noted at penoscrotal junction with normal anal tone and opening. Read More

    Free serratus anterior artery perforator flap: a case report with an anatomic and radiological study.
    Surg Radiol Anat 2017 Feb 24. Epub 2017 Feb 24.
    Department of Hand Surgery, Plastic Surgery, Burn Surgery, CHU University of Bordeaux, Centre François-Xavier-Michelet, Groupe Hospitalier Pellegrin, Place Amélie-Raba-Léon, 33076, Bordeaux, France.
    Perforator flaps have become very popular in reconstructive surgery. The thoracodorsal and lateral thoracic artery perforator flaps are highly studied, and successful clinical series have been reported, whereas the literature concerning the lateral intercostal and serratus anterior artery perforator flaps is quite poor and their vascular anatomy needs yet to be clarified. We describe a case of free serratus anterior artery perforator flap for the reconstruction of a dorsal defect of the foot, followed by an anatomic and radiological study. Read More

    Exosomes derived from human amniotic epithelial cells accelerate wound healing and inhibit scar formation.
    J Mol Histol 2017 Apr 22;48(2):121-132. Epub 2017 Feb 22.
    Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shannxi, China.
    Wound healing is a highly orchestrated physiological process consisting of a complex events, and scarless wound healing is highly desired for the development and application in clinical medicine. Recently, we have demonstrated that human amniotic epithelial cells (hAECs) promoted wound healing and inhibited scar formation through a paracrine mechanism. However, exosomes (Exo) are one of the most important paracrine factors. Read More

    Primary cutaneous diffuse large B cell lymphoma-other successfully treated by the combination of R-CHOP chemotherapy and surgery: A case report and review of literature.
    Medicine (Baltimore) 2017 Feb;96(8):e6161
    aDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, School of Medicine bDepartment of Pathology, Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Xi'an Jiaotong University, School of Medicine, Xi'an, China.
    Rationale: The occurrence of primary cutaneous diffuse large B cell lymphoma-other (PCDLBCL-O) has been rarely reported in the literature. Its diagnosis is based on histopathological and immunohistochemical examinations. To improve the clinical diagnosis and treatment for PCDLBCL-O, we report a case of PCDLBCL-O successfully treated by the combination of R-CHOP (A chemotherapy protocol consists of cyclophosphamide, doxorubicin, vincristine, prednisone plus Rituximab) chemotherapy and surgery. Read More

    FKBP51 Immunohistochemical Expression: A New Prognostic Biomarker for OSCC?
    Int J Mol Sci 2017 Feb 18;18(2). Epub 2017 Feb 18.
    Department of Advanced Biomedical Sciences, University "Federico II", 80131 Naples, Italy.
    Up-to-date, several molecular markers of prognosis have been studied in Oral Squamous Cell Carcinoma (OSCC), but none entered in the clinical setting. Therapy of OSCC tumors mainly relies on surgery, radiotherapy and partially on chemotherapy; there is an urgent need for biomarkers able to better stratify OSCC patients' risk to address targeted therapeutic strategies. The role of immune response in the pathogenesis and biological behavior of OSCC has been investigated by several authors, and promising results have been obtained with immune checkpoint inhibitors. Read More

    Effects of Remote Ischemic Preconditioning on Heme Oxygenase-1 Expression and Cutaneous Wound Repair.
    Int J Mol Sci 2017 Feb 17;18(2). Epub 2017 Feb 17.
    Department of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands.
    Skin wounds may lead to scar formation and impaired functionality. Remote ischemic preconditioning (RIPC) can induce the anti-inflammatory enzyme heme oxygenase-1 (HO-1) and protect against tissue injury. We aim to improve cutaneous wound repair by RIPC treatment via induction of HO-1. Read More

    Resection of Gastrointestinal Metastases in Stage IV Melanoma: Correlation with Outcomes.
    Am Surg 2016 Nov;82(11):1109-1116
    Department of Cutaneous Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
    The prognosis of patients with gastrointestinal (GI) melanoma metastases is poor. Surgery renders select patients disease free and/or palliates symptoms. We reviewed our single-institution experience of resection with GI melanoma metastases. Read More

    Lateral femoral cutaneous nerve transposition: Renaissance of an old concept in the light of new anatomy.
    Clin Anat 2017 Apr;30(3):409-412
    Department of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, Madison, Wisconsin, 53792.
    Meralgia paresthetica causes pain in the anterolateral thigh. Most surgical procedures involve nerve transection or decompression. We conducted a cadaveric study to determine the feasibility of lateral femoral cutaneous nerve (LFCN) transposition. Read More

    Chemosaturation With Percutaneous Hepatic Perfusion in Unresectable Hepatic Metastases.
    Cancer Control 2017 Jan;24(1):96-101
    Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL.
    Background: In patients with hepatic metastases from solid-organ malignancies, surgical resection may be a potentially curative option, but it is not possible in most cases. Chemosaturation with percutaneous hepatic perfusion was developed for the management of unresectable metastases to the liver.

    Methods: Relevant medical literature was summarized with regard to the outcomes and limitations of chemosaturation with percutaneous hepatic perfusion. Read More

    Cervical spine arteriovenous fistula associated with hereditary haemorrhagic telangiectasia.
    BMJ Case Rep 2017 Feb 7;2017. Epub 2017 Feb 7.
    Department of Neurology, St Vincent's University Hospital, Dublin, Ireland.
    Reported is a case of a man aged 55 years who presented with progressive spastic paraparesis. Examination demonstrated multiple cutaneous telangiectases. Subsequent development of upper limb weakness, acute urinary retention and eventual respiratory compromise resulted in the requirement for intensive care unit admission and mechanical ventilation. Read More

    Lateral arm free tissue transfer for parotid reconstruction: A pictorial essay.
    Head Neck 2017 May 7;39(5):1015-1019. Epub 2017 Feb 7.
    Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, The James Cancer Hospital and Solove Research Institute, Columbus, Ohio.
    Background: The goals of parotid reconstruction are to provide accurate volume reconstruction of the defect while minimizing ptosis, optimize color match to surrounding facial skin, maintain anatomic position of the auricle, and to perform facial nerve rehabilitation in cases in which the facial nerve is removed.

    Methods And Results: For many complex parotid defects, the lateral arm free tissue transfer achieves these reconstructive goals and is the ideal donor site for microvascular reconstruction. In this pictorial essay, we describe the anatomy, harvest, inset, and reconstructive advantages of the lateral arm free tissue transfer in complex parotid reconstruction. Read More

    Low-Grade Neuroendocrine Carcinoma of the Skin (Primary Cutaneous Carcinoid Tumor) as a Distinctive Entity of Cutaneous Neuroendocrine Tumors: A Clinicopathologic Study of 3 Cases With Literature Review.
    Am J Dermatopathol 2017 Apr;39(4):250-258
    *Department of Diagnostic Pathology, Kainan Hospital, Yatomi, Japan; †Sapporo Dermatopathology Institute, Sapporo, Japan; ‡Department of Plastic and Reconstructive Surgery, Saitama Medical University, Saitama, Japan; §Departments of Dermatology, and ¶Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan; and ‖Department of Breast Surgery, Kainan Hospital, Yatomi, Japan.
    There is scarcity of information on primary cutaneous low-grade neoplasms commonly known as carcinoid tumors, owing to their rarity. The authors present 3 cases that were named "low-grade neuroendocrine carcinoma of the skin" (LGNECS). These occurred in the dermis and subcutis of the anterior chest or the inguinal region in the elderly. Read More

    Bikini versus traditional incision direct anterior approach: is there any difference in soft tissue damage?
    Hip Int 2017 Feb 6. Epub 2017 Feb 6.
    Department of Anatomy and Cell Biology, Western University, Ontario - Canada.
    Introduction: The direct anterior approach for total hip replacements has reported advantages of improved early function and muscle preservation. In an effort to improve healing and cosmesis, a change in the orientation of the incision has been proposed. Traditionally, the skin incision is in-line with the tensor fasciae latae muscle belly. Read More

    Sebaceous Carcinoma Treated With Mohs Micrographic Surgery.
    Dermatol Surg 2017 Feb;43(2):281-286
    *Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York;†Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri.
    Background: Sebaceous carcinoma is a rare and potentially aggressive adnexal neoplasm with historic data indicating high rates of recurrence, metastasis, and cancer-specific mortality.

    Objective: To evaluate the incidence of local recurrence, metastasis, disease-specific mortality, and all-cause mortality and to identify work-up approaches.

    Patients And Methods/materials: Retrospective review of patients with sebaceous carcinoma treated with Mohs micrographic surgery between 2001 and 2013 at one institution. Read More

    Clinical and pathologic factors associated with subclinical spread of invasive melanoma.
    J Am Acad Dermatol 2017 Apr 28;76(4):714-721. Epub 2017 Jan 28.
    Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
    Background: Indications to treat invasive melanoma with Mohs micrographic surgery (MMS) or analogous techniques with exhaustive microscopic margin assessment have not been defined.

    Objective: Identify clinical and histologic factors associated with subclinical spread of invasive melanoma.

    Methods: This retrospective, cross-sectional study evaluated 216 invasive melanomas treated with MMS and melanoma antigen recognized by T cells 1 immunostaining. Read More

    Perforator variability in the anterolateral thigh free flap: a systematic review.
    Surg Radiol Anat 2017 Jan 30. Epub 2017 Jan 30.
    Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.
    Objectives: The use of free flaps greatly improves reconstruction options and quality of life for patients undergoing oncological resections. The anterolateral thigh (ALT) free flap is frequently used in the head and neck. The aim of this review was to provide a summary of published evidence assessing perforator anatomy of this flap. Read More

    Primary cerebral malignant melanoma: A case report with literature review.
    Medicine (Baltimore) 2017 Jan;96(4):e5805
    aDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University bDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Dongcheng District, Beijing, P. R. China cDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, MA dDepartment of Neurovascular Surgery, Chinese Armed Police General Hospital, Haidian District eDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Xuanwu District, Beijing, P. R. China.
    Primary intracranial melanomas are uncommon and constitute approximately 1% of all melanoma cases and 0.07% of all brain tumors. In nature, these primary melanomas are very aggressive and can spread to other organs. Read More

    A reappraisal of the surgical planning of the superficial circumflex iliac artery perforator flap.
    J Plast Reconstr Aesthet Surg 2017 Apr 22;70(4):469-477. Epub 2016 Dec 22.
    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Electronic address:
    Objective: The popularity of the superficial circumflex iliac artery perforator (SCIP) flap has been limited by factors such as variable vascular anatomy and short arterial pedicle. This article aimed to delineate flap design and harvest strategies based around either the proximal or distal perforators of the superficial circumflex iliac artery (SCIA) and propose a set of strategies that can help deal with the limitations of the flap.

    Method: From August 2011 to June 2015, the SCIP flap was used in 80 patients for soft tissue defects at our institution. Read More

    Experimental Study of the Effects of Nanodispersed Ceria on Wound Repair.
    Bull Exp Biol Med 2017 Jan 14;162(3):395-399. Epub 2017 Jan 14.
    N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
    We studied the effects of nanodispersed ceria on wound healing in vitro and in vivo. It was found that cerium dioxide stimulated wound healing, which manifested in shrinkage of burn wound area (by 1.5 times) and intensification (by 2. Read More

    Clinical factors associated with subclinical spread of in situ melanoma.
    J Am Acad Dermatol 2017 Apr 7;76(4):707-713. Epub 2017 Jan 7.
    Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
    Background: Subclinical spread of in situ melanoma occurs at a wide frequency, ranging from 12% to 71%.

    Objective: To identify clinical factors associated with subclinical spread of in situ melanoma.

    Methods: We used a retrospective, cross-sectional study of 674 consecutive in situ melanomas to examine 627 patients treated with Mohs surgery and melanoma antigen recognized by T cells 1 immunostaining. Read More

    Venous drainage of the face.
    J Plast Reconstr Aesthet Surg 2017 Apr 14;70(4):433-440. Epub 2016 Dec 14.
    Department of Plastic and Reconstructive Surgery, Fujita Health University School of Medicine, Tokyo, Japan.
    The venous anatomy of the face was examined in 12 fresh cadavers. Venograms and arteriovenograms were obtained after the injection of contrast medium. In 8 of the 12 cadavers, a large loop was formed by the facial vein, the supratrochlear vein, and the superficial temporal vein, which became the main trunk vein of the face. Read More

    A stab wound to the axilla illustrating the importance of brachial plexus anatomy in an emergency context: a case report.
    J Med Case Rep 2017 Jan 4;11(1). Epub 2017 Jan 4.
    Anatomy Department, NOVA Medical School, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056, Lisbon, Portugal.
    Background: Although open injuries involving the brachial plexus are relatively uncommon, they can lead to permanent disability and even be life threatening if accompanied by vascular damage. We present a case report of a brachial plexus injury in which the urgency of the situation precluded the use of any ancillary diagnostic examinations and forced a rapid clinical assessment.

    Case Presentation: We report a case of a Portuguese man who had a stabbing injury at the base of his left axilla. Read More

    Endoscopic Anatomy and Features of Anterior Cervical Foraminotomy by Destandau Technique.
    Open Access Maced J Med Sci 2016 Dec 22;4(4):650-653. Epub 2016 Nov 22.
    Department of Neurosurgery, International Neurosciences Institute, Hannover, Germany.
    Background: Minimally invasive spine surgery limits surgical trauma and avoids traditional open surgery so in the majority of cases, recovery is much quicker and patients have less pain after surgery.

    Aim: The authors describe an endoscopic approach to anterior cervical foraminotomy (ACF) by Destandau's method.

    Material And Methods: Anterior cervical foraminotomy by Destandau's method is carried out under general anaesthesia. Read More

    Vascular Supply of the Auricle: Anatomical Study and Applications to External Ear Reconstruction.
    Dermatol Surg 2017 Jan;43(1):87-97
    *Department of Head and Neck Surgery, University Hospital, Nantes, France;†Laboratory of Anatomy, Nantes University Hospital, Nantes, France;‡Department of Dermatology, Nantes University Hospital, Nantes, France.
    Background: Reliable reconstructive flaps require convenient vascular supply. Thus, precise description of the vascular patterns of external ear is not completely elucidated.

    Objective: This anatomical study aims to provide comprehensive data of the arterial network of the auricular region, anastomosis, and patterns of arterial dependence regarding external ear subunits. Read More

    Anatomy of the Platysma Muscle.
    J Craniofac Surg 2017 Mar;28(2):539-542
    Department of Plastic Surgery, Inha University School of Medicine, Incheon, Korea.
    The aim of this paper was to review the anatomy the platysma systematically.The term "platysma AND anatomy" was used to search PubMed and Scopus, producing 394 and 214 papers, respectively. After excluding 95 duplicate titles, 513 abstracts and 98 full papers were reviewed. Read More

    Differentiating Intralymphatic Histiocytosis, Intravascular Histiocytosis, and Subtypes of Reactive Angioendotheliomatosis: Review of Clinical and Histologic Features of All Cases Reported to Date.
    Am J Dermatopathol 2017 Jan;39(1):33-39
    *Virginia Tech Carilion Dermatology and Mohs Surgery, Roanoke, VA; and †Cleveland Clinic, Dermatology and Plastic Surgery Institute, Cleveland, OH.
    Reactive angioendotheliomatosis (REA) is a rare benign angioproliferative condition of the skin, which has been noted to occur in patients with a variety of underlying systemic diseases. Histopathologically, this condition is characterized by vascular proliferation, and endothelial cell hyperplasia within the lumina and around dermal vessels, without significant cellular atypia. Since the first case of RAE was reported in 1958, multiple histologic patterns of benign cutaneous vascular proliferations with similar clinical presentations to RAE have been described in the literature and have been proposed as subtypes of the originally described condition. Read More

    Is sentinel lymph node biopsy warranted for desmoplastic melanoma? A systematic review.
    J Plast Reconstr Aesthet Surg 2017 Feb 16;70(2):274-280. Epub 2016 Nov 16.
    Department of Plastic and Reconstructive Surgery, St George's Hospital, Blackshaw Rd, Tooting, London, SW17 0QT, United Kingdom.
    Background: Desmoplastic melanoma (DM) is an uncommon malignancy associated with a high local recurrence rate. The aim of this systematic review was to determine the positivity rate of sentinel lymph node biopsy (SLNB) in patients with DM. The secondary outcome was to establish if SLNB is warranted for both pure DM (PDM) and mixed DM (MDM). Read More

    MiR-21 and miR-205 are induced in invasive cutaneous squamous cell carcinomas.
    Arch Dermatol Res 2017 Mar 24;309(2):133-139. Epub 2016 Dec 24.
    Department of Dermatology and Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller School of Medicine, 1600 N.W. 10th Avenue, RMSB, Room 2023-A, Miami, FL, 33136, USA.
    Cutaneous squamous cell carcinoma (cSCC) is a malignant proliferation of keratinocytes with an uncertain molecular basis causing significant morbidity. MicroRNAs (miRs) are small RNA molecules that regulate gene expression on post- transcriptional level. MiRs are critical to various biological processes. Read More

    Anatomical variability and histological structure of the ulnar nerve in the Guyon's canal.
    Arch Orthop Trauma Surg 2017 Feb 23;137(2):277-283. Epub 2016 Dec 23.
    Department of Anatomy, Jagiellonian University Medical College, 12 Kopernika St, 31-034, Krakow, Poland.
    Objectives: The goal of our study was to analyze the prevalence of variations, branching patterns, and histology of the ulnar nerve (UN) in Guyon's canal to address its importance in hand surgery, particularly decompression of the UN.

    Methods: Fifty fresh cadavers were dissected bilaterally, and the nerve in the area of Guyon's canal was visualized. Samples for histology were also taken and prepared. Read More

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