29,374 results match your criteria Anatomy in Cutaneous Surgery

Treatment of painful median nerve neuroma using pedicled vascularized lateral antebrachial cutaneous nerve with adipofascial flap: a cadaveric study and exploration of clinical application.

J Plast Surg Hand Surg 2021 Jun 9:1-5. Epub 2021 Jun 9.

Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Japan.

The most common procedure for the treatment of painful median nerve neuroma is coverage with vascularized soft tissue following external neurolysis. However, the ideal treatment should include reconnecting the proximal and distal stumps of the damaged nerve to allow the growth of regenerating axons to their proper targets for a functional recovery. We developed a useful technique employing radial artery perforator adipofascial flap including the lateral antebrachial cutaneous nerve (LABCN) to repair the median nerve by vascularized nerve grafting and to achieve coverage of the nerve with vascularized soft tissue. Read More

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Auricular reconstruction after Mohs micrographic surgery: analysis of 101 cases.

An Bras Dermatol 2021 Jun 2. Epub 2021 Jun 2.

Dermatology Service, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil; Postgraduate Program in Internal Medicine and Health Sciences, Universidade Federal do Paraná, Curitiba, PR, Brazil; Private Practice, Curitiba, PR, Brazil.

Background: The ear is a region that has a high prevalence of cutaneous carcinomas and several guidelines indicate Mohs micrographic surgery as the first-choice treatment in such cases. Although the technique allows maximum preservation of healthy tissue, many auricular surgical wounds constitute a challenge due to the peculiar local anatomy, with evident curves and reliefs. Auricular reconstruction should prioritize function before aesthetics, but without leaving the latter aside, since postoperative distortions can have a significant psychological impact. Read More

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Fluorescence angiography-assisted debridement of critically perfused glabrous skin in degloving foot injuries: Two case reports.

Medicine (Baltimore) 2021 Jun;100(22):e26235

Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Rationale: Degloving foot injuries are challenging to treat and associated with life-long sequelae for patients. An appropriate debridement of ischemic soft tissues with maximal preservation of glabrous skin is key during the reconstruction of these injuries. Indocyanine green (ICG) fluorescence angiography is an established technique for the intraoperative evaluation of tissue perfusion. Read More

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Construction of autophagy prognostic signature and analysis of prospective molecular mechanisms in skin cutaneous melanoma patients.

Medicine (Baltimore) 2021 Jun;100(22):e26219

Spine and Osteopathy Ward, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi.

Background: Autophagy is closely related to skin cutaneous melanoma (SKCM), but the mechanism involved is unclear. Therefore, exploration of the role of autophagy-related genes (ARGs) in SKCM is necessary.

Materials And Methods: Differential expression autophagy-related genes (DEARGs) were first analysed. Read More

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Total Denervation of the Elbow: Cadaveric Feasibility Study.

J Hand Surg Am 2021 May 29. Epub 2021 May 29.

Department of Orthopaedic Surgery, Hôpital Pierre-Paul Riquet, Toulouse, France.

Purpose: Total elbow arthroplasty for the treatment of patients with severe elbow osteoarthritis is associated with postoperative activity limitations and risk of midterm complications. Elbow denervation could be an attractive therapeutic option for young, active patients. The aim of our study was to assess the feasibility of selective total elbow denervation via 2 anteriorly based approaches. Read More

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Do-It-Yourself Preoperative High-Resolution Ultrasound-Guided Flap Design of the Superficial Circumflex Iliac Artery Perforator Flap (SCIP).

J Clin Med 2021 May 30;10(11). Epub 2021 May 30.

Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.

The superficial circumflex iliac artery perforator (SCIP) flap is a well-documented, thin, free tissue flap with a minimal donor site morbidity, and has the potential to become the new method for resurfacing moderate-size skin defects. The aim of this study is to describe an easy, reliable, systematic, and standardized approach for preoperative SCIP flap design and perforator characterization, using color-coded duplex sonography (CCDS). A list of customized settings and a straightforward algorithm are presented, which are easily applied by an operator with minimal experience. Read More

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Improvement of Superficial and Deep Cutaneous Microcirculation Due to Axillary Plexus Anesthesia Impaired by Smoking.

J Clin Med 2021 May 14;10(10). Epub 2021 May 14.

Department of Plastic Surgery and Hand Surgery, Burn Center, BG Universitätsklinikum Bergmannsheil Bochum, Ruhr-University Bochum, 44789 Bochum, Germany.

Background: Understanding microvascular physiology is key to any reconstructive procedure. Current concepts in anesthesia increasingly involve regional peripheral nerve blockade during microvascular reconstructive procedures. Whereas favorable effects on perfusion due to these techniques have been reported earlier, little evidence focusing on its effects in most peripheral vascular compartments is available. Read More

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Lower Extremity Ulcers.

Med Clin North Am 2021 Jul;105(4):663-679

Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 N.W. 10th Avenue, RMSB, Room 2023-A, USA. Electronic address:

Lower extremity ulcerations contribute to significant morbidity and economic burden globally. Chronic wounds, or those that do not progress through healing in a timely manner, are estimated to affect 6.5 million people in the United States alone causing, significant morbidity and economic burden of at least an estimated $25 billion annually. Read More

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Recognition, Staging, and Management of Melanoma.

Med Clin North Am 2021 Jul;105(4):643-661

Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02466, USA. Electronic address:

Melanoma accounts for approximately 1% of all skin cancers but contributes to almost all skin cancer deaths. The developing picture suggests that melanoma phenotypes are driven by epigenetic mechanisms that reflect a complex interplay between genotype and environment. Furthermore, the growing consensus is that current classification standards, notwithstanding pertinent clinical history and appropriate biopsy, fall short of capturing the vast complexity of the disease. Read More

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[Research advances on the role and mechanism of inflammatory response in the formation of hypertrophic scars and keloids].

Zhonghua Shao Shang Za Zhi 2021 May;37(5):490-494

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.

Hypertrophic scars and keloids are common sequelae after wound healing, with a high incidence, which seriously affect the patient's quality of life. However, there is still a lack of effective prevention and treatment methods, mainly because the pathogenesis of scars is not clear. Current research believe that inflammatory response plays a critical role in the process of scar formation, and through the researches on the mechanisms it is hopeful to find new potential therapeutic drug targets for the prevention and treatment of hypertrophic scars and keloids. Read More

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Impact of Circulating and Tissue Biomarkers in Adjuvant and Neoadjuvant Therapy for High-Risk Melanoma: Ready for Prime Time?

Am J Clin Dermatol 2021 May 25. Epub 2021 May 25.

Unit of Medical Oncology, Department of Surgery and Medicine, University of Perugia, Perugia, Italy.

The prognosis of patients with metastatic melanoma has substantially improved over the last years with the advent of novel treatment strategies, mainly immune checkpoint inhibitors and BRAF and MEK inhibitors. Given the survival benefit provided in the metastatic setting and the evidence from prospective clinical trials in the early stages, these drugs have been introduced as adjuvant therapies for high-risk resected stage III disease. Several studies have also investigated immune checkpoint inhibitors, as well as BRAF and MEK inhibitors, for neoadjuvant treatment of high-risk stage III melanoma, with preliminary evidence suggesting this could be a very promising approach in this setting. Read More

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Duplicated transverse cervical nerve and external jugular vein.

Anat Cell Biol 2021 May 25. Epub 2021 May 25.

Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, USA.

The transverse cervical nerve arises from anterior rami of the second and third cervical spinal nerves via the cervical plexus. We present a case of a left duplicated transverse cervical nerve with a duplicated external jugular vein in a 72-year-old female cadver. The transverse cervical nerve bifurcated into two branches, . Read More

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Eccrine poroma presented as spindle-shaped plaque: A case report.

Medicine (Baltimore) 2021 May;100(20):e25971

Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, School of Medicine, Xi'an, China.

Rationale: Eccrine poroma, a benign cutaneous neoplasm originating from the intraepidermal portion of the eccrine sweat duct, is relatively common in clinical practice. Nevertheless, the 1 presenting as spindle-shaped plaque is extremely rare and easily misdiagnosed as seborrheic keratosis or other dermatoses. Thus, the current study demonstrates a case of eccrine poroma with unique clinical manifestation. Read More

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Digital ischaemia aetiologies and mid-term follow-up: A cohort study of 323 patients.

Medicine (Baltimore) 2021 May;100(20):e25659

Department of Internal Medicine.

Abstract: Upper extremity digital ischaemia (UEDI) is a rare heterogeneous condition whose frequency is 40 times less than that of toe ischaemia. Using a large cohort, the aim of this study was to evaluate aetiologies, prognosis and midterm clinical outcomes of UEDI.All patients with UEDI with or without cutaneous necrosis in a university hospital setting between January 2000 to December 2016 were included. Read More

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[Reconstruction of complex tissue defects in temporal region: report of 3 cases].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 May;56(5):487-492

Institute of Otolaryngology, Chinese PLA General Hospital, Beijing 100853, China National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China.

To discuss the techniques and repairing methods of various degree of compound tissue defects in the auriculotemporal region. Retrospective analysis was conducted on three cases of different repairing methods for huge compound tissue defects in different degrees in the auriculotemporal region after the resection of the malignant tumor or sinus tract due to repeated infection in our hospital. Following total removal of the tumors or sinus tract in all patients, we applied retroauricular lingual flap transfer repairing, latissimus dorsi flap free transfer repairing and vascular anastomosis, scalp tissue expansion in stage Ⅰ, then repairing the lesion with expanded scalp and filling the huge mastoid cavity with abdominal fat in stage Ⅱ, respectively, according to the characteristics of compound tissue defects in the auriculotemporal region. Read More

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Encoding of limb state by single neurons in the cuneate nucleus of awake monkeys.

J Neurophysiol 2021 05 19. Epub 2021 May 19.

Department of Biomedical Engineering, Northwestern University, Evanston, IL, United States.

The cuneate nucleus (CN) is among the first sites along the neuraxis where proprioceptive signals can be integrated, transformed, and modulated. The objective of the study was to characterize the proprioceptive representations in CN. To this end, we recorded from single CN neurons in three monkeys during active reaching and passive limb perturbation. Read More

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[Anatomical and clinical rationale for the use of a perforant flap from the periauricular region the blood-supplied from pool of the superficial temporal artery].

Khirurgiia (Mosk) 2021 (5):78-88

Medical Research and Education Center University Clinic of the Lomonosov Moscow State University, Moscow, Russia.

There is an urgent desire to use a method for the reconstruction of facial tissues that allows not only to reliably eliminate the defect, but also to recreate all the features of the damaged area, with an inconspicuous scar and minimal trauma. But one of the most difficult issues in microsurgical autotransplantation of tissues of the maxillofacial area is the choice of the donor area and vessels for the safe and adequate isolation and revascularization of flaps.

The Aim Of The Study: Was to increase the efficiency of functional and aesthetic results of surgical treatment by developing new flaps from the STA pool while eliminating limited soft tissue facial defects. Read More

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Innervation of digital joints: an anatomical overview.

Surg Radiol Anat 2021 May 6. Epub 2021 May 6.

Department of Orthopedic Surgery, Rouen University Hospital, Rouen, France.

Introduction: The innervation of the digital joints as well as the anatomical relationships of the articular branches is present in this anatomical work to determine the technical feasibility of a selective and efficient denervation of the digital joints.

Materials And Methods: A study of 40 distal interphalangeal (DIP), 40 proximal interphalangeal (PIP), 50 metacarpophalangeal (MCP), 10 interphalangeal (IP) of the thumb, and 10 trapezo-metacarpophalangeal (TMC) joints was performed on ten hands. Under magnification and a proper surgical approach, we collected the course, the source origin, the number of articular nerve branches, and their caliber. Read More

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The immune cell landscape of metastatic uveal melanoma correlates with overall survival.

J Exp Clin Cancer Res 2021 May 4;40(1):154. Epub 2021 May 4.

Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.

Background: Uveal melanoma (UM) represents the most common primary intra-ocular malignancy in adults. Up to 50% of the patients develop distant metastases within 10 years from diagnosis, with the liver as the most common site. Upon metastatization, life expectancy strongly reduces and immune checkpoint inhibitors that prove effective in cutaneous melanoma do not modify clinical outcome. Read More

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Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki 8891692, Japan.

Dermal wound healing describes the progressive repair and recalcitrant mechanism of 12 damaged skin, and eventually, reformatting and reshaping the skin. Many probiotics, nutritional supplements, metal nanoparticles, composites, skin constructs, polymers, and so forth have been associated with the improved healing process of wounds. The exact mechanism of material-cellular interaction is a point of immense importance, particularly in pathological conditions such as diabetes. Read More

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Autocrine and Paracrine Effects of Vascular Endothelial Cells Promote Cutaneous Wound Healing.

Biomed Res Int 2021 10;2021:6695663. Epub 2021 Apr 10.

Department of Plastic Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine, Ministry of Education, Guangzhou, Guangdong Province 510630, China.

Background: When vascular endothelial cells are subjected to external stimuli, paracrine hormones and cytokines act on adjacent cells. The regulation of the biological behaviour of cells is closely related to the maintenance of organ function and the occurrence and development of disease. However, it is unclear whether vascular endothelial cells affect the biological behaviour of cells involved in wound repair through autocrine and paracrine mechanisms and ultimately play a role in wound healing. Read More

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Dilemmas in the management of rhinophyma in pigmented individuals.

Ann R Coll Surg Engl 2021 May;103(5):e165-e168

Queen Victoria Hospital NHS Trust, East Grinstead, UK.

Rhinophyma affects predominantly the Caucasian population and is rare in those with Fitzpatrick skin type IV-VI. Diagnosis is based on clinical evaluation. Prominent features include abnormal coloration and texture of skin, impaired vascularity, irregular nodular exophytic growth and telangiectasia. Read More

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Elevated APOBEC mutational signatures implicate chronic injury in etiology of an aggressive head-and-neck squamous cell carcinoma: a case report.

J Med Case Rep 2021 Apr 30;15(1):252. Epub 2021 Apr 30.

Department of Dermatology, University of California, San Francisco, CA, 94115, USA.

Background: Aggressive squamous cell carcinomas (SCCs) present frequently in the context of chronic skin injury occurring in patients with the congenital blistering disease recessive dystrophic epidermolysis bullosa. Recently, these cancers were shown to harbor mutation signatures associated with endogenous deaminases of the active polynucleotide cytosine deaminase family, collectively termed APOBEC, and clock-like COSMIC [Catalogue of Somatic Mutations in Cancer] signatures, which are associated with normal aging and might result from cumulative DNA replication errors. We present a case of a nasal septal SCC arising in the context of recurrent injury, but also modest past tobacco use. Read More

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Prognostic and Predictive Biomarkers in Stage III Melanoma: Current Insights and Clinical Implications.

Int J Mol Sci 2021 Apr 27;22(9). Epub 2021 Apr 27.

Department of Medical Sciences, Dermatologic Clinic, University of Turin, 10126 Turin, Italy.

Melanoma is one of the most aggressive skin cancers. The 5-year survival rate of stage III melanoma patients ranges from 93% (IIIA) to 32% (IIID) with a high risk of recurrence after complete surgery. The introduction of target and immune therapies has dramatically improved the overall survival, but the identification of patients with a high risk of relapse who will benefit from adjuvant therapy and the determination of the best treatment choice remain crucial. Read More

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Pretreatment with High Mobility Group Box-1 Monoclonal Antibody Prevents the Onset of Trigeminal Neuropathy in Mice with a Distal Infraorbital Nerve Chronic Constriction Injury.

Molecules 2021 Apr 2;26(7). Epub 2021 Apr 2.

Department of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Persistent pain following orofacial surgery is not uncommon. High mobility group box 1 (HMGB1), an alarmin, is released by peripheral immune cells following nerve injury and could be related to pain associated with trigeminal nerve injury. Distal infraorbital nerve chronic constriction injury (dIoN-CCI) evokes pain-related behaviors including increased facial grooming and hyper-responsiveness to acetone (cutaneous cooling) after dIoN-CCI surgery in mice. Read More

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Cellular Senescence and Inflammaging in the Skin Microenvironment.

Int J Mol Sci 2021 Apr 8;22(8). Epub 2021 Apr 8.

Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 107-11, Korea.

Cellular senescence and aging result in a reduced ability to manage persistent types of inflammation. Thus, the chronic low-level inflammation associated with aging phenotype is called "inflammaging". Inflammaging is not only related with age-associated chronic systemic diseases such as cardiovascular disease and diabetes, but also skin aging. Read More

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The Molecular Landscape of Primary Acral Melanoma: A Multicenter Study of the Italian Melanoma Intergroup (IMI).

Int J Mol Sci 2021 Apr 7;22(8). Epub 2021 Apr 7.

Pathological Anatomy Unit, Padua University Hospital, 35128 Padua, Italy.

Acral melanoma (AM) is a rare and aggressive subtype of melanoma affecting the palms, soles, and nail apparatus with similar incidence among different ethnicities. AM is unrelated to ultraviolet radiation and has a low mutation burden but frequent chromosomal rearrangements and gene amplifications. Next generation sequencing of 33 genes and somatic copy number variation (CNV) analysis with genome-wide single nucleotide polymorphism arrays were performed in order to molecularly characterize 48 primary AMs of Italian patients in association with clinicopathological and prognostic features. Read More

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Nitroglycerin patch use in digital ischemia secondary to sepsis: a case report.

Pan Afr Med J 2021 3;38:114. Epub 2021 Feb 3.

Neonatal Intensive Care Unit, Al Jalila Children´s Specialty Hospital, Dubai, United Arab Emirates.

Sepsis results in intense disturbances in homoeostasis and is responsible for considerable morbidity and mortality in early infancy. Owing to insufficiency on part of infant to develop adequate inflammatory response to localize the infection, they usually progress to disseminated systemic infection, pneumonia and/or meningitis. We present the case of a 26 weeks preterm boy with acute digital ischemia in right index finger progressing to impending gangrene as a manifestation of septicemia. Read More

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Three-dimensional histological explanation of the dermoscopy patterns in acral melanocytic lesions.

J Dermatol 2021 Apr 27. Epub 2021 Apr 27.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Dermoscopic images of pigmented lesions have distinct features on the sole where skin ridges and furrows exist. Pigmentation of benign nevus usually locates on the skin furrow, while the malignant melanoma is pigmented on the skin ridge. Correspondence between dermoscopy and pathology in the pigmented lesions on soles have been studied based on conventional vertical pathological images. Read More

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Meralgia Paresthetica: A Case Report With an Update on Anatomy, Pathology, and Therapy.

Cureus 2021 Mar 17;13(3):e13937. Epub 2021 Mar 17.

Neurology, Flowers Medical Group, Dothan, USA.

Meralgia paresthetica, a condition characterized by tingling, numbness, and burning pain in the lateral aspect of the thigh, is caused by compression of the lateral femoral cutaneous nerve. The incidence of meralgia paresthetica increases with obesity and diabetes. The unique anatomy of the nerve that tunnels through the inguinal ligament predisposes it to inflammation, trauma, and entrapment. Read More

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