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    The Use of Ultrasonography to Identify the Intersection of the Dorsomedial Cutaneous Nerve of the Hallux and the Extensor Hallucis Longus Tendon: A Cadaveric Study.
    J Foot Ankle Surg 2018 Jan 11. Epub 2018 Jan 11.
    Professor and Vice Chair and Director of Anatomy Division, Department of Pathology, Anatomy, and Laboratory Medicine, West Virginia University School of Medicine, Morgantown, WV.
    Terminal branches of the superficial fibular nerve are at risk of iatrogenic damage during foot surgery, including hallux valgus rigidus correction, bunionectomy, cheilectomy, and extensor hallucis longus tendon transfer. One terminal branch, the dorsomedial cutaneous nerve of the hallux, is particularly at risk of injury at its intersection with the extensor hallucis longus tendon. Iatrogenic injuries of the dorsomedial cutaneous nerve of the hallux can result in sensory loss, neuroma formation, and/or debilitating causalgia. Read More

    Lumbar to sacral root rerouting to restore bladder function in a feline spinal cord injury model: Urodynamic and retrograde nerve tracing results from a pilot study.
    Neurourol Urodyn 2018 Jan 4. Epub 2018 Jan 4.
    Department of Anatomy and Cell Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
    Aims: Lumbar to sacral rerouting surgery can potentially allow voiding via a skin-central nervous system-bladder reflex pathway. Here, we assessed if this surgery was effective in treating neurogenic bladder dysfunction/sphincter in felines.

    Methods: Eight cats underwent spinal cord transection (SCT) at thoracic level 10/11. Read More

    Left extensive infection in the forearm caused by whitlow infected by mycobacterium tuberculosis: A case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8992
    Department of Hand Surgery, Wuxi No. 9 People's Hospital Affiliated to Soochow University, Wuxi, China.
    Introduction: Whitlow is a common disease in clinic, characterized by pain and swelling of finger. However, few articles had reported on extensive infection in the forearm caused by whitlow infected by mycobacterium tuberculosis (MTB).

    Patient Concerns: A 70-year-old Chinese female complained of fester in back of left hand for 5 days. Read More

    The significance of BRAF V600E mutation status discordance between primary cutaneous melanoma and brain metastases: The implications for BRAF inhibitor therapy.
    Medicine (Baltimore) 2017 Dec;96(48):e8404
    To compare BRAF V600E status of primary melanoma and brain metastases to assess for discordance by cross-sectional study, and to evaluate clinical implications on BRAF inhibitor therapy.Brain metastases are common in patients with advanced melanoma. Between 40% and 60% of melanomas demonstrate BRAF mutations, BRAF V600E being most common. Read More

    Branchial anomalies in children: A report of 105 surgical cases.
    Int J Pediatr Otorhinolaryngol 2018 Jan 29;104:14-18. Epub 2017 Oct 29.
    Department of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China. Electronic address:
    Background: Branchial anomalies (BAs) account for 20% of all congenital masses in children. We sought to review the incidence of involvement of individual anomalies, diagnostic methods, surgical treatment, and complications of BAs in children. In addition, we also classified our study and analyzed a congenital lower neck cutaneous fistula near the sternoclavicular joint that was thought to be the skin-side remnant of the fourth BAs. Read More

    The Best of Abdominal Wall Reconstruction.
    Plast Reconstr Surg 2018 01;141(1):113e-136e
    Leicester, United Kingdom; and Winnipeg, Manitoba, Canada From the Department of Plastic Surgery, Leicester Royal Infirmary, University Hospitals of Leicester; and the Department of Surgery, Section of Plastic Surgery, Health Sciences Center, University of Manitoba.
    Learning Objectives: After reviewing this article, the participant should be able to: 1. List major risk factors for hernia formation and for failure of primary repair. 2. Read More

    Microbial Evaluation in Capsular Contracture of Breast Implants.
    Plast Reconstr Surg 2018 01;141(1):23-30
    Naples, Italy From the Department of Plastic, Reconstructive and Aesthetic Surgery, the Department of Experimental Medicine, Section of Virology and Microbiology, Università della Campania Luigi Vanvitelli; the Unit of Plastic, Reconstructive and Aesthetic Surgery, Università Federico II; and the Department of Public Health.
    Background: Capsular contracture around breast implants is a severe and unpredictable complication experienced by up to 50 percent of patients after breast augmentation and reconstruction, and represents a major cause leading to reoperation. Several lines of evidence point to the involvement of subclinical infections and of bacterial biofilm formation.

    Methods: To reduce the incidence of capsular contracture following mammaplasty, the authors studied the correlation between contamination by exogenous and endogenous bacterial flora and the capacity to develop bacterial biofilm in mammary implants. Read More

    Venous stent placement ameliorates cutaneous microvascular function in iliocaval venous obstruction.
    J Vasc Surg Venous Lymphat Disord 2018 Jan 22;6(1):57-65. Epub 2017 Sep 22.
    Department of Medical Pharmacology, Faculty of Medicine, Ankara University, Ankara, Turkey.
    Background: The role of cutaneous microvascular dysfunction is well known in the development of chronic venous disease. However, the effects of venous obstruction on microcirculation have not been well investigated. The aim of this study was to assess cutaneous microvascular function in patients with iliocaval venous obstruction (ICVO) before and after venous stent placement. Read More

    Anterior Elbow Pain Caused by Compression of the Lateral Antebrachial Cutaneous Nerve.
    J Orthop Case Rep 2017 Sep-Oct;7(5):63-66
    Department of Orthopaedics, University Hospital South Manchester, UK.
    Introduction: The complex anatomy and biomechanics of the elbow joint can lead to diagnostic uncertainty when a clinician is determining the cause of a patient's anterior elbow pain. We present a case of anterior elbow pain with an uncommon and often overlooked etiology. Elbow pain due to compression of the lateral antebrachial nerve (LACN) has an unknown incidence or prevalence. Read More

    Transfusion of ethylene carbodiimide-fixed donor splenocytes prolongs survival of vascularized skin allografts.
    J Surg Res 2018 Jan 19;221:343-352. Epub 2017 Oct 19.
    Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China. Electronic address:
    Background: Allograft rejection is a major obstacle to the widespread clinical application of vascularized composite allotransplantation. Recent studies revealed a noncytoreductive strategy to protect allografts by the transfusion of ethylene carbodiimide-fixed donor splenocytes (ECDI-SPs). To determine whether this approach offers advantages in protecting skin allografts, we examined the immunological protection of infusing ECDI-SPs with a 30-d administration of rapamycin on the skin allografts of mice. Read More

    Patterns of sural nerve innervation of the sural artery with implication for reconstructive surgery.
    J Surg Res 2017 Dec;220:261-267
    Orthopedic Department, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China. Electronic address:
    Background: Most of the literature concerning the neurocutaneous flap is related to its anatomic investigation and clinical application, and the more in-depth physiological problem such as whether the cutaneous nerve contains sympathetic fibers that innervate its accompanying vessels has never been explored.

    Materials And Methods: Dissection was first performed on three rabbits. In another 22 rabbits, two rabbits undergoing no surgery were used as the normal control group. Read More

    The anatomy of forearm free flap phalloplasty for transgender surgery.
    Clin Anat 2017 Nov 27. Epub 2017 Nov 27.
    Pediatric Urology, University of Pittsburgh Hamot Medical Center, Erie, Pennsylvania, 16503.
    Transgender surgeries are becoming more frequent and visual interpretation of anatomy is essential for both surgeons and patients. Since the forearm free flap phalloplasty was introduced in 1984, it has been known to provide reliable cosmetic and functional results for transitioning men compared with phalloplasty by different flaps. Surgical text descriptions were enhanced by the creation of new anatomic illustrations. Read More

    Anatomy of the pedicled anterolateral thigh flap for phalloplasty in transitioning-males.
    Clin Anat 2017 Nov 27. Epub 2017 Nov 27.
    Department of Urology, UPMC Hamot, Erie, Pennsylvania.
    Incidence of transexualism and request for neophalloplasty is increasing yielding a current prevalence of trans-male in the USA of 1:2500. Surgeons have explored various techniques to improve desirable outcomes of neophallic construction, decrease the length of surgery, and minimize stigmatizing scars. The anterolateral thigh (ALT) flap is an alternative to the traditional radial forearm flap for patients who do not want a forearm scar. Read More

    Blind versus ultrasound-guided maxillary nerve block in donkeys.
    Vet Anaesth Analg 2017 Jul 15. Epub 2017 Jul 15.
    Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt.
    Objectives: To describe the 'blind' and ultrasound-guided approaches to block the maxillary nerve in donkeys. To compare the success and complication rates between the 'blind' and ultrasound-guided techniques based on staining of nerves and other structures in cadavers and assessing level of analgesia in live animals.

    Study Design: Prospective anatomical and experimental study. Read More

    European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers.
    Eur J Cancer 2017 12;87:172-181
    Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Experimental Drug and Gene Electrotransfer (C*EDGE), Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark. Electronic address:
    Aim: Electrochemotherapy is an effective local treatment for cutaneous tumours and metastases. In this prospective trial, six European institutions investigated electrochemotherapy in recurrent, mucosal head and neck tumours.

    Patient And Methods: Forty-three patients with recurrent mucosal head and neck tumours and no further curative or reasonably effective palliative treatment options were enrolled and treated with electrochemotherapy. Read More

    Primary malignant melanoma of the gallbladder with multiple metastases: A case report.
    Medicine (Baltimore) 2017 Nov;96(46):e8793
    aDepartment of Biliary Surgery bDepartment of Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
    Rational: Primary malignant melanoma of the gallbladder is an extremely rare tumor, with fewer than 40 cases reported in the literature worldwide. The majority of patients presented as a solitary lesion in the gallbladder. To our knowledge, only one case of primary malignant melanoma of the gallbladder with multiple metastases has been reported, which involved the stomach, duodenum, pancreas, jejunum and a mesenteric lymph node. Read More

    A rare case of Merkel cell carcinoma presenting as a giant intra-thoracic mass: A case report and review of the literature.
    Medicine (Baltimore) 2017 Nov;96(46):e8743
    aDepartment of General Surgery, Xuzhou Infectious Disease Hospital bDepartment of Thoracic Surgery cDepartment of Respiratory Medicine, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, China.
    Rationale: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine-derived cutaneous cancer. Ectopic or single metastatic MCC located in thorax is extremely rare; meanwhile, its definite management has not been elucidated yet.

    Patient Concerns: A 64-year-old female patient with a giant mass located in her left thorax was presented for stuffy pain of left chest for 6 months and fever for half a month. Read More

    Bilateral femoral posterior neurocutaneous perforater flap successfully treating Fournier gangrene: A case report.
    Medicine (Baltimore) 2017 Nov;96(46):e8720
    Department of Hand Surgery, Wuxi NO.9 People's Hospital Affiliated to Soochow University, Wuxi, China.
    Rationale: Necrotizing fasciitis (NF), characterized by widespread fascial necrosis, is a rare disease in clinic. Fournier gangrene (FG) is a special type of NF involved of perineum and scrotum. To our knowledge, no article has reported on bilateral femoral posterior neurocutaneous perforater flap treating for FG. Read More

    Anatomical etiology of "pseudo-sciatica" from superior cluneal nerve entrapment: a laboratory investigation.
    J Pain Res 2017 1;10:2539-2545. Epub 2017 Nov 1.
    Department of Anatomy, Tokyo Medical University, Tokyo, Japan.
    Objective: The superior cluneal nerve (SCN) may become entrapped where it pierces the thoracolumbar fascia over the iliac crest; this can cause low back pain (LBP) and referred pain radiating into the posterior thigh, calf, and occasionally the foot, producing the condition known as "pseudo-sciatica." Because the SCN was thought to be a cutaneous branch of the lumbar dorsal rami, originating from the dorsal roots of L1-L3, previous anatomical studies failed to explain why SCN causes "pseudo-sciatica". The purpose of the present anatomical study was to better elucidate the anatomy and improve the understanding of "pseudo-sciatica" from SCN entrapment. Read More

    Role of amniotic membrane and full-thickness skin graft in reconstruction of kissing nevus of eyelids.
    Indian J Ophthalmol 2017 Nov;65(11):1219-1221
    Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    A 20-year-old girl presented with a large pigmented lesion over the temporal aspect of left lateral canthus involving the lateral one-third of both eyelids, since birth. A slow increase in its size had been noticed for the past 2 years. On examination, a hairy nevus measuring 34 mm × 22 mm was noticed involving left eyelid skin, the mucocutaneous junction (MCJ), palpebral conjunctiva, and lateral canthus. Read More

    Clinicopathological predictors of recurrence in nodular and superficial spreading cutaneous melanoma: a multivariate analysis of 214 cases.
    J Transl Med 2017 Nov 7;15(1):227. Epub 2017 Nov 7.
    Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Sassari, Italy.
    Background: Nodular melanoma (NM) accounts for most thick melanomas and because of their frequent association with ulceration, fast growth rate and high mitotic rate, contribute substantially to melanoma-related mortality. In a multicentric series of 214 primary melanomas including 96 NM and 118 superficial spreading melanoma (SSM), histopathological features were examined with the aim to identify clinicopathological predictors of recurrence.

    Methods: All consecutive cases of histopathologically diagnosed primary invasive SSM and NM during the period 2005-2010, were retrieved from the 12 participating Italian Melanoma Intergroup (IMI) centers. Read More

    Role of imaging in the diagnosis of parotid infantile hemangiomas.
    Int J Pediatr Otorhinolaryngol 2017 Nov 4;102:61-66. Epub 2017 Sep 4.
    Vascular Anomalies Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Division of Vascular and Interventional Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:
    Objectives: To review the clinical presentation, imaging and follow-up of parotid infantile hemangiomas (IH).

    Methods: Over a 15-year period, all patients with a clinical diagnosis of parotid IH were evaluated. Imaging was available in 35. Read More

    Is initial excision of cutaneous melanoma by General Practitioners (GPs) dangerous? Comparing patient outcomes following excision of melanoma by GPs or in hospital using national datasets and meta-analysis.
    Eur J Cancer 2017 11 5;86:373-384. Epub 2017 Nov 5.
    Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. Electronic address:
    Background: Melanomas are initially excised in primary care, and rates vary internationally. Until now, there has been no strong evidence one way or the other that excising melanomas in primary care is safe or unsafe. European guidelines make no recommendations, and the United Kingdom (UK) melanoma guidelines require all suspicious skin lesions to be initially treated in secondary care based on an expert consensus, which lacks supporting evidence, that primary care excision represents substandard care. Read More

    The structure of the cutaneous pedal glands in the banded snail Cepaea hortensis (Müller, 1774).
    J Morphol 2018 Feb 3;279(2):187-198. Epub 2017 Nov 3.
    Faculty of Life Science, Core Facility Cell Imaging and Ultrastructure Research, University of Vienna, Vienna, Austria.
    Although gastropods have been crawling through the ocean and on the land for 60 million years, we still know very little about the sticky mucus produced in their foot. Most research has been focused on marine species in particular and, to a lesser extent, on the well-known terrestrial species Arion vulgaris and Cornu aspersum. Within this study, we aim to characterize the foot anatomy of a smaller representative of the family Helicidae, the banded snail Cepaea hortensis. Read More

    Glucagonoma syndrome with serous oligocystic adenoma: A rare case report.
    Medicine (Baltimore) 2017 Oct;96(43):e8448
    aDiabetic Foot Center, Department of Endocrinology and Metabolism bDepartment of Pathology cDepartment of Pancreatic Surgery dDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
    Rationale: Glucagonoma and pancreatic serous oligocystic adenoma (SOA) are rare neuroendocrine and exocrine tumors of the pancreas, respectively. The coexistence of glucagonoma syndrome (GS) and SOA is a rare clinical condition and has not yet been reported. Additionally, necrolytic migratory erythema (NME), a hallmark clinical sign of GS, is often misdiagnosed as other skin lesions by clinicians due to their lack of related knowledge, which delays diagnosis of GS and thus exacerbates the prognosis. Read More

    Eyelid Reconstruction.
    Plast Reconstr Surg 2017 Nov;140(5):724e-735e
    Houston, Texas From the Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center.
    Learning Objectives: After reading this article, the participant should be able to: 1. Describe eyelid anatomy and demonstrate full understanding of the critical structures and basic principles of eyelid reconstruction. 2. Read More

    Optimizing Male Periorbital Rejuvenation.
    Dermatol Surg 2017 Nov;43 Suppl 2:S196-S202
    *Charlotte Plastic Surgery, Charlotte, North Carolina; †Hofstra University Northwell School of Medicine, New York, New York; ‡Dallas Plastic Surgery Institute, Dallas, Texas.
    Background: Facial rejuvenation continues to be an increasing trend among males. The periorbital region deserves special mention given the overall differences in aesthetics between sexes.

    Objective: To examine the aesthetics of the upper eyelid, lower eyelid, lateral canthus, and brow with respect to male periorbital rejuvenation. Read More

    New Drug Combination Strategies in Melanoma: Current Status and Future Directions.
    Anticancer Res 2017 11;37(11):5941-5953
    Laboratory of Oncology and Experimental Surgery Institute Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium
    Melanoma is the deadliest form of skin cancer and one of the most difficult cancers to treat. Overall, melanomas have more mutations than any other cancer type. Oncogenic mutations in c-KIT, NRAS and BRAF components of the MAPK pathway have been identified in nearly 90% of cutaneous melanoma and this information has been used to develop small molecules that inhibit their activity. Read More

    Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
    World Neurosurg 2018 Jan 20;109:362-364. Epub 2017 Oct 20.
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA.
    Background: Germline pathogenic variants in BRCA1-associated protein-1 (BAP1), a nuclear ubiquitin carboxy-terminal hydrolase with evidence suggestive of independent tumor suppressor function, predispose affected families to uveal melanoma, cutaneous melanoma, renal cell carcinoma, malignant mesothelioma, and possibly a range of other tumors and malignancies as part of the BAP1 tumor predisposition syndrome, a recently recognized hereditary cancer syndrome.

    Case Description: A 50-year-old woman presented with a malignant peripheral nerve sheath tumor of the left fifth metatarsal head. Further examination revealed a right renal mass and left breast mass. Read More

    [Effects of improved V-Y advancement flap with major artery perforator on repairing skin and soft tissue defects].
    Zhonghua Shao Shang Za Zhi 2017 Oct;33(10):611-615
    Department of Burns and Reconstructive Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To explore the effect of improved V-Y advancement flap with major artery perforator on repairing several skin and soft tissue defects in whole body. Methods: From March 2015 to June 2017, 4 cases with pressure ulcer in sacrococcygeal region, 4 cases with pressure ulcer at ischial tuberosity, 2 cases with scalp and skull defects at occiput, 1 case with secondary wound after tumor resection in axillary region, and 2 cases with skin and soft tissue defects caused by other trauma were hospitalized, with disease duration ranging from 1 week to 6 months. Bones, blood vessels, or nerves were exposed in wounds of 11 cases. Read More

    [Clinical effects of middle and low peroneal artery perforator flap with pedicle on repairing skin and soft tissue defects of ankle].
    Zhonghua Shao Shang Za Zhi 2017 Oct;33(10):607-610
    Department of Burns and Plastic Surgery, the Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China.
    Objective: To investigate clinical effects of middle and low peroneal artery perforator flap with pedicle on repairing skin and soft tissue defects of ankle. Methods: Twenty patients with skin and soft tissue defects of ankle and exposure of tendon and bone were admitted in our burn wards from April 2012 to December 2015. The size of skin and soft tissue defects ranged from 5 cm×4 cm to 23 cm×10 cm. Read More

    [Effects of flap or myocutaneous flap combined with fascia lata or composite mesh on repairing severe high-voltage electrical burn wounds in abdomen of patients].
    Zhonghua Shao Shang Za Zhi 2017 Oct;33(10):602-606
    Department of Burns, Beijing Jishuitan Hospital, Beijing 100035, China.
    Objective: To investigate the effects of flap or myocutaneous flap combined with fascia lata or composite mesh on repairing wounds in abdomen of patients with severe high-voltage electrical burn. Methods: From January 2010 to May 2017, 11 patients with severe high-voltage electrical burn in abdomen were hospitalized in our burn wards. In 3 hours to 7 days after burn, operation was performed when patients were in stable condition. Read More

    Spinal Cavernous Angioma Associated with Klippel-Trenaunay-Weber Syndrome: Case Report and Literature Review.
    World Neurosurg 2018 Jan 17;109:333-337. Epub 2017 Oct 17.
    Department of Neurological Surgery, Nippon Medical School, Tokyo, Japan.
    Background: Klippel-Trenaunay-Weber syndrome (KTWS) is a rare congenital vascular disorder characterized by the classic triad of cutaneous nevi, venous varicosities, and osseous and soft tissue hypertrophy of the affected limb. Various vascular anomalies of the central nervous system have also been described in patients with KTWS. The English language literature to date contains 6 reports of associations between KTWS and spinal cord cavernous angioma (CA), but management of these patients has not been well described. Read More

    Determination of the impact of melanoma surgical timing on survival using the National Cancer Database.
    J Am Acad Dermatol 2018 Jan 17;78(1):40-46.e7. Epub 2017 Oct 17.
    Department of Dermatology and Plastic Surgery, Cleveland Clinic, Cleveland, Ohio. Electronic address:
    Background: The ideal timing for melanoma treatment, predominantly surgery, remains undetermined. Patient concern for receiving immediate treatment often exceeds surgeon or hospital availability, requiring establishment of a safe window for melanoma surgery.

    Objective: To assess the impact of time to definitive melanoma surgery on overall survival. Read More

    Inhibition of apoptosis signal-regulating kinase 1 alters the wound epidermis and enhances auricular cartilage regeneration.
    PLoS One 2017 18;12(10):e0185803. Epub 2017 Oct 18.
    Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States of America.
    Why regeneration does not occur in mammals remains elusive. In lower vertebrates, epimorphic regeneration of the limb is directed by the wound epidermis, which controls blastema formation to promote regrowth of the appendage. Herein, we report that knockout (KO) or inhibition of Apoptosis Signal-regulated Kinase-1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), after full thickness ear punch in mice prolongs keratinocyte activation within the wound epidermis and promotes regeneration of auricular cartilage. Read More

    Superficial temporal artery perforator flap: Anatomic study of number and reliability of distal branches of the superficial temporal artery and clinical applications in three cases.
    Microsurgery 2017 Nov 16;37(8):924-929. Epub 2017 Oct 16.
    Unit of Plastic Surgery and Dermatology, Campus Bio-Medico University, Via Alvaro del Portillo, 200, Rome 00128, Italy.
    Background: Limited information is available about the anatomical feasibility and clinical applications of flaps based on distal divisions of the superficial temporal artery (STA). The aim of this study was to investigate the anatomy of the STA, focusing on the number and reliability of distal branches and to show representative cases for the use of such flaps for zygomatic, parieto-frontal and occipital reconstructions.

    Methods: Fifty volunteers were examined bilaterally by Doppler to investigate the presence and variability of the distal divisions of STA branches. Read More

    Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual.
    CA Cancer J Clin 2017 Nov 13;67(6):472-492. Epub 2017 Oct 13.
    Professor of Melanoma and Surgical Oncology, Melanoma Institute Australia, The University of Sydney and Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
    Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses of this new database, the existing seventh edition AJCC stage IV database, and contemporary clinical trial data, the AJCC Melanoma Expert Panel introduced several important changes to the Tumor, Nodes, Metastasis (TNM) classification and stage grouping criteria. Key changes in the eighth edition AJCC Cancer Staging Manual include: 1) tumor thickness measurements to be recorded to the nearest 0. Read More

    Variations in the Anatomical Structures of the Guyon Canal.
    Plast Surg (Oakv) 2017 May 30;25(2):84-92. Epub 2017 Mar 30.
    Division of Plastic Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
    Background: Compression neuropathy of the ulnar nerve at the Guyon canal is commonly seen by hand surgeons. Different anatomical variations of structures related to the Guyon canal have been reported in the literature. A thorough knowledge of the normal contents and possible variations is essential during surgery and exploration. Read More

    Anatomy of the vasculature of the lower leg and harvest of a fibular flap: a systematic review.
    Br J Oral Maxillofac Surg 2017 Nov 9;55(9):904-910. Epub 2017 Oct 9.
    Department of Oral & Maxillofacial Surgery, St. Richard's Hospital, Western Sussex Hospitals NHS Foundation Trust, Chichester PO19 6SE, UK. Electronic address:
    The fibular free flap (FFF) is based on the peroneal artery, which has a consistent anatomy and makes a minimal contribution to the pedal circulation. However, certain anatomical variations in the vasculature of the leg might leave the peroneal artery with a major role in the perfusion of the foot, and to raise a FFF could lead to ischaemic complications. Our aim was to review the implications of anatomical variants on planning and harvest of a FFF. Read More

    [The clinical observation of NK/T-cell lymphoma of the nasal type].
    Vestn Otorinolaringol 2017;82(4):64-68
    L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152.
    The objective of the present work was to present the results of the clinical analysis of the patient presenting with natural killer (NK)/T-cell lymphoma of the nasal type. We undertook the analysis of the medical documentation concerning the case of interest. It was shown that the development of progressive perforation of the nasal septum and the pronounced destructive changes in the intranasal and adjacent structures following the endonasal surgical interventions made necessary differential diagnostics between the condition under consideration and certain latent disorders (such as Wegener's granulomatosis, leprosy, syphilis, leishmaniasis, dirofilariasis tuberculosis, etc. Read More

    An RNA-targeted therapy for dystrophic epidermolysis bullosa.
    Nucleic Acids Res 2017 Sep;45(17):10259-10269
    EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria.
    Functional impairment or complete loss of type VII collagen, caused by mutations within COL7A1, lead to the severe recessive form of the skin blistering disease dystrophic epidermolysis bullosa (RDEB). Here, we successfully demonstrate RNA trans-splicing as an auspicious repair option for mutations located in a wide range of exons by fully converting an RDEB phenotype in an ex vivo pre-clinical mouse model based on xenotransplantation. Via a self-inactivating (SIN) lentiviral vector a 3' RNA trans-splicing molecule, capable of replacing COL7A1 exons 65-118, was delivered into type VII collagen deficient patient keratinocytes, carrying a homozygous mutation in exon 80 (c. Read More

    Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy.
    Brain 2017 Oct;140(10):2557-2569
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
    Non-freezing cold injury develops after sustained exposure to cold temperatures, resulting in tissue cooling but not freezing. This can result in persistent sensory disturbance of the hands and feet including numbness, paraesthesia and chronic pain. Both vascular and neurological aetiologies of this pain have been suggested but remain unproven. Read More

    Sentinel lymph node biopsy versus observation in thick melanoma: A multicenter propensity score matching study.
    Int J Cancer 2018 Feb 13;142(3):641-648. Epub 2017 Oct 13.
    Dermatology Department, Instituto Valenciano de Oncología, Valencia, Spain.
    The clinical value of sentinel lymph node (SLN) biopsy in thick melanoma patients (Breslow >4 mm) has not been sufficiently studied. The aim of the study is to evaluate whether SLN biopsy increases survival in patients with thick cutaneous melanoma, and, as a secondary objective, to investigate correlations between survival and lymph node status. We included 1,211 consecutive patients with thick melanomas (>4 mm) registered in the participating hospitals' melanoma databases between 1997 and 2015. Read More

    The Functional Angiosome: Clinical Implications of the Anatomical Concept.
    Plast Reconstr Surg 2017 Oct;140(4):721-733
    Parkville, Victoria, Australia From the Taylor Lab, Department of Anatomy and Neuroscience, and the Royal Melbourne Hospital Department of Surgery, University of Melbourne.
    Background: The angiosome is a three-dimensional block of tissue supplied by a source vessel with its boundary outlined either by an anastomotic perimeter of reduced-caliber choke vessels or by true anastomoses with no reduction of vessel caliber. This article focuses on the role of these anastomotic vessels in defining flap survival or the necrotic pattern seen in fulminating meningococcal septicemia.

    Methods: Experiments in pigs, dogs, guinea pigs, and rabbits over the past 46 years were reviewed, focusing on the necrosis line of flaps, the effects of various toxins in vivo, and correlating these results in the clinical setting. Read More

    Facial Assessment and Injection Guide for Botulinum Toxin and Injectable Hyaluronic Acid Fillers: Focus on the Midface.
    Plast Reconstr Surg 2017 Oct;140(4):540e-550e
    São Paulo, Brazil; Aalst, Belgium; Rio de Janeiro, Brazil; and Dallas, Texas From the Clinica Dr. Maurício de Maio; the Aalst Dermatology Clinic, private practice; and the University of Texas Southwestern Medical Center.
    This second article of a three-part series addresses techniques and recommendations for aesthetic treatment of the midface. Injectable fillers are important for rejuvenation of the midface by replacing lost volume and providing structural support; neuromodulators play a smaller role in this facial region. Fillers are used for volumization and contouring of the midface regions, including the upper cheek and lid-cheek junction and the submalar and preauricular areas. Read More

    An ecological study of skin biopsies and skin cancer treatment procedures in the United States Medicare population, 2000 to 2015.
    J Am Acad Dermatol 2018 Jan 22;78(1):47-53. Epub 2017 Sep 22.
    Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:
    Background: Analyses of skin cancer procedures adjusted for population changes are needed.

    Objective: To describe trends in skin cancer-related biopsies and procedures in Medicare beneficiaries.

    Methods: An ecological study of Medicare claims for skin biopsies and skin cancer procedures in 2000 to 2015. Read More

    Modification of fasciocutaneous radial forearm free flap to achieve two-layer closure during reconstruction of circumferential hypopharyngeal defects.
    Eur Ann Otorhinolaryngol Head Neck Dis 2017 Sep 21. Epub 2017 Sep 21.
    Department of Ear Nose and Throat, Manchester Head and Neck Cancer Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
    Circumferential defects of the hypopharynx are a reconstructive challenge. Various local, regional and free flaps have been described with each having advantages and disadvantages in terms of functional outcomes. The fasciocutaneous radial forearm free flap (RFFF) is one of the most common free flaps used for reconstructing circumferential hypopharyngeal defects. Read More

    Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and wound re-epithelialization in human skin.
    Exp Dermatol 2017 Dec 7;26(12):1199-1206. Epub 2017 Nov 7.
    Institute of Anatomy, University of Luebeck, Luebeck, Germany.
    Previous reports have demonstrated that cell-derived nanoparticles (CDNPs) composed of bovine or porcine protein complexes exerted therapeutic effects against viral infections and cancer in mice and humans. Based on these observations, we asked whether CDNPs would improve inflammatory skin disorders. To address this, we utilized two distinct mouse models of cutaneous inflammation: the autoimmune skin-blistering disease epidermolysis bullosa acquisita (EBA) as an example of an autoantibody-induced cutaneous inflammation, and Leishmania major (L. Read More

    Muscle versus Fasciocutaneous Free Flaps in Lower Extremity Traumatic Reconstruction: A Multicenter Outcomes Analysis.
    Plast Reconstr Surg 2018 01;141(1):191-199
    Durham, N.C.; and Philadelphia, Pa. From the Division of Plastic and Reconstructive Surgery, Duke University Medical Center; the Department of Bioengineering, University of Pennsylvania; and the Division of Plastic Surgery and the Department of Orthopaedic Surgery, University of Pennsylvania Health System.
    Background: Clinical indications are expanding for the use of fasciocutaneous free flaps in lower extremity traumatic reconstruction. The authors assessed the impact of muscle versus fasciocutaneous free flap coverage on reconstructive and functional outcomes.

    Methods: A multicenter retrospective review was conducted on all lower extremity traumatic free flaps performed at Duke University (1997 to 2013) and the University of Pennsylvania (2002 to 2013). Read More

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