30,704 results match your criteria Anatomy in Cutaneous Surgery

Head CT Image Segmentation and Three-Dimensional Reconstruction Technology Based on Human Anatomy.

Comput Intell Neurosci 2022 16;2022:7091476. Epub 2022 Jun 16.

Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.

With the continuous development of computer science and technology, the level of medical image processing and analysis technology has been significantly improved. In order to further optimize the medical imaging technology and provide assistance for medical diagnosis and treatment, this study will explore the head CT image segmentation technology and three-dimensional reconstruction technology based on human anatomy, using two morphological operation methods of image expansion and image corrosion, as well as the triangulation method based on surface contour, Optimize CT image segmentation technology and three-dimensional reconstruction technology. The results show that the CT image segmentation technology based on human anatomy can obtain the more essential morphology and features of the target image, and significantly improve the image quality. Read More

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Role of Inflammasomes in Keloids and Hypertrophic Scars-Lessons Learned from Chronic Diabetic Wounds and Skin Fibrosis.

Int J Mol Sci 2022 Jun 19;23(12). Epub 2022 Jun 19.

Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo 113-8603, Japan.

Keloids and hypertrophic scars are pathological cutaneous scars. They arise from excessive wound healing, which induces chronic dermal inflammation and results in overwhelming fibroblast production of extracellular matrix. Their etiology is unclear. Read More

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Galunisertib Exerts Antifibrotic Effects on TGF-β-Induced Fibroproliferative Dermal Fibroblasts.

Int J Mol Sci 2022 Jun 15;23(12). Epub 2022 Jun 15.

Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.

Dermal fibroblasts in pathological scars secrete constitutively elevated levels of TGF-β, signaling the transcription of fibrotic genes via activin-like kinase 5 (ALK5). In the present study, we examine the antifibrotic effects of galunisertib, a small-molecule inhibitor of ALK5, on fibroproliferative dermal fibroblasts in an in vitro model of wound healing. We induced fibrosis in human dermal fibroblasts with exogenous TGF-β and performed cellular proliferation assays after treatment with varying concentrations of galunisertib. Read More

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J Fam Pract 2022 May;71(4):178-179

Department of Dermatology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.

THE COMPARISONA. Acral lentiginous melanoma on the sole of the foot of a 30-year-old Black woman. The depth of the lesion was 2 mm with a positive sentinel lymph node biopsy. Read More

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Resurfacing of Face and Neck Using Superthin Thoracodorsal Artery Perforator Free Flaps.

J Craniofac Surg 2022 May 1;33(3):931-934. Epub 2021 Oct 1.

Department of Plastic and Reconstructive Surgery, College of Medicine, Hanyang University, Seoul, South Korea.

Background: Resurfacing of facial and neck defects is challenging due to the unique skin color, texture, and thickness of the region. With the development of microsurgical reconstruction, perforator- free flaps can provide adequate soft tissue. However, despite various modifications, such flaps hardly satisfy cosmetic requirements, due to differences in color and bulkiness. Read More

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Use of the O-Z Flap to Repair Scalp Defects After Cancer Tumor Resection.

J Craniofac Surg 2022 May 26;33(3):892-894. Epub 2021 Oct 26.

Ningbo City First Hospital, Ningbo, China.

Background: Large benign and malignant tumors in the scalp cannot be sutured directly after resection. Instead, skin grafting or skin flap repair is the most commonly used techniques. Local tissue depression and lack of hair growth are some of the drawbacks associated with these techniques. Read More

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Use of Serial Flap Transfer Technique in En Bloc Reconstruction of Extensive Soft Tissue Defects in the Head and Neck.

J Craniofac Surg 2022 May 12;33(3):809-813. Epub 2021 Apr 12.

Department of Plastic and Reconstructive Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Shijingshan District, Beijing, china.

Abstract: En bloc reconstruction of extensive head and neck defects is feasible with matched tissue from the medial arm or chest. Nevertheless, the donor site faces significant morbidity following massive cutaneous flap harvesting. The serial flap transfer technique can increase the reconstructive ability of these flaps and minimize the donor site morbidity. Read More

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[Reconstruction of facial skin defects by the V-Y subcutaneous pedicle flap].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):718-723

Department of Otolaryngology, Guangdong Province Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528200, China.

To investigate the method and efficacy of reconstruction of facial skin defects after removing the lesions by applying the V-Y subcutaneous pedicle flap. A retrospective analysis was performed on 23 patients with facial reconstruction by using V-Y subcutaneous pedicle flap in the Otolaryngology Department of Guangdong Integrated Traditional Chinese and Western Medicine Hospital from March 2012 to April 2021. Patient ages ranged from 45 to 85 years old, with a mean age of 66. Read More

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Perianal basal cell carcinoma managed with wide excision and random flap reconstruction.

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Department of Surgery, University of the Philippines-Philippine General Hospital, Manila, Metro Manila, Philippines.

Basal cell carcinoma (BCC) is a common skin malignancy and usually occurs in sun-exposed areas like the head and neck. Occurrence in the perianal area is rare, accounting for only 0.08% of all BCC, and 0. Read More

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[Stereotactic radiotherapy with CyberKnife and linear accelerator in the management of malignant melanoma].

Magy Onkol 2022 Jun 28;66(2):127-133. Epub 2022 May 28.

Onkodermatológiai Osztály, Országos Onkológiai Intézet, Budapest, Hungary.

Stereotactic radiotherapy gains more and more importance in the management of malignant melanoma, owing to technical developments of recent years. This approach might be applied with success in solitary or oligometastatic cases, since the deliverable biological dose is far higher than that of conventional radiotherapy. Beyond chemotherapy of decreasing importance, there is a widening range of new targeted and immunotherapy agents, leading to longer survival times even in disseminated stages. Read More

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Second-Intention Healing in Mohs Micrographic Surgery: A Single-Center Academic Experience.

Adv Skin Wound Care 2022 Jul;35(7):375-380

Julián Barrera-Llaurador, MD, is Dermatology Assistant Professor, Department of Dermatology, University of Puerto Rico School of Medicine, San Juan. Osward Y. Carrasquillo, MD, MPH, is Mohs Micrographic Surgery Fellow, Department of Dermatology, University of North Carolina, Chapel Hill. Marely Santiago-Vázquez, MD, is Dermatology Resident, Department of Dermatology, University of Puerto Rico School of Medicine. Valeria J. González-Molina, MD, is Clinical Fellow, Department of Dermatology, HCA Corpus Christi Medical Center-Bay Area, Texas. Sheila M. Valentín-Nogueras, MD, is Mohs Micrographic Surgeon, Director of Dermatologic Surgery, Department of Dermatology, University of Puerto Rico School of Medicine. The authors have disclosed no financial relationships related to this article. Submitted August 18, 2021; accepted in revised form January 10, 2022.

Objective: To describe the trends in second-intention healing (SIH) use at a single Mohs micrographic surgery (MMS) dermatology clinic and assess outcomes and patient satisfaction.

Methods: The authors conducted a single-center, retrospective study of patients who underwent MMS from November 2012 through November 2018. Data obtained for each patient included sex, age, tumor characteristics, number of MMS stages, final defect size, and postoperative complications. Read More

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M6A-Related Bioinformatics Analysis Reveals a New Prognostic Risk Signature in Cutaneous Malignant Melanoma.

Dis Markers 2022 6;2022:8114731. Epub 2022 Jun 6.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.

Cutaneous malignant melanoma (CMM) is the most deadly skin cancer worldwide. Despite advances in the treatments of CMM, its incidence and mortality rates are still increasing. N6-methyladenosine (m6A) is the most common form of RNA modification and has attracted increasing interest in cancer initiation and progression. Read More

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[Recurrent Darier-Ferrand dermatofibrosarcoma in the abdominal wall: the role of preoperative radiotherapy (case report)].

Pan Afr Med J 2022 22;41:234. Epub 2022 Mar 22.

Service de Radiothérapie, CHU Mohammed VI, Oujda, Maroc.

Dermatofibrosarcoma is a rare cancer, accounting for 0.01% of all cancers. We here report the case of a 44-year-old female patient presenting with the 5 recurrence of locally advanced Darier-Ferrand dermatofibrosarcoma, that progressed on many cycles of neoadjuvant therapy and required emergency radiotherapy with good response. Read More

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Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review.

BMC Neurol 2022 Jun 18;22(1):223. Epub 2022 Jun 18.

Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Background: Eccrine spiradenocarcinoma (SC), also known as malignant eccrine spiradenoma, is a rare malignant cutaneous adnexal neoplasm arising from long-standing benign eccrine spiradenoma. Malignant skin tumors rarely show direct intracranial invasion. However, once the intracranial structure is infiltrated, curative excision with sufficient margins can become extremely difficult, particularly when the venous sinuses are involved. Read More

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[Application of free transverse gracilis myocutaneous flap for soft tissue defects of foot and ankle].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2022 Jun;36(6):766-769

Department of Trauma and Microreconstructive Surgery, Orthopaedic Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.

Objective: To investigate the effectiveness of free transverse gracilis myocutaneous flap for soft tissue defects of foot and ankle.

Methods: Between January 2017 and December 2020, 16 cases (17 feet) of soft tissue defects of foot and ankle were repaired with free transverse gracilis myocutaneous flaps. There were 10 males and 6 females, with an average age of 38 years (range, 23-60 years). Read More

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Controlling Inflammation Pre-Emptively or at the Time of Cutaneous Injury Optimises Outcome of Skin Scarring.

Front Immunol 2022 27;13:883239. Epub 2022 May 27.

Plastic and Reconstructive Surgery Research, National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, University of Manchester, Manchester, United Kingdom.

Inflammation plays an active role during the wound healing process. There is a direct association between the extent of injury as well as inflammation and the amount of subsequent cutaneous scarring. Evidence to date demonstrates that high levels of inflammation are associated with excessive dermal scarring and formation of abnormal pathological scars such as keloids and hypertrophic scars. Read More

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Subcutaneous Lateral Temporal Lift.

Clin Plast Surg 2022 Jul 13;49(3):365-375. Epub 2022 May 13.

Northwell Health System/Hofstra University, Zucker School of Medicine, Manhattan Eye, Ear and Throat Hospital, 1009 Park Avenue, New York, NY 10028, USA. Electronic address:

Over the past decades, the understanding of the nuances of forehead anatomy and facial aging has grown immensely. Safe and reliable options for forehead rejuvenation followed. Although noninvasive techniques are an important adjunct in forehead rejuvenation, the mainstay of treatment of the eyebrow is operative intervention. Read More

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Brow Anatomy and Aesthetics of the Upper Face.

Clin Plast Surg 2022 Jul;49(3):339-348

Cleveland Clinic Department of Plastic Surgery, 9500 Eucllid Avenue, Cleveland Ohio 44195, USA.

The surgical approach to the brow has changed perhaps more than any other facial esthetic procedure in the past 20 years. Understanding the functional anatomy of the upper face is the best means of maximizing results and minimizing untoward events in this region. The surgical and clinical correlation is addressed in detail in this article. Read More

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Facial Plast Surg 2022 Jun 16. Epub 2022 Jun 16.

Facial Plastic Surgery, FACEISTANBUL, istanbul, Turkey.

Facelift techniques can be classified according to the depth and extent of the dissection applied. Imbrication and plication of the SMAS referred to as "SMAS lifts" or "classical facelifts" are the most commonly used techniques. Plication techniques involve in-folding of the SMAS and suture suspension without any SMAS incision whereas imbrication techniques involve a SMAS incision with a portion of the SMAS either removed or transposed with or without limited subSMAS dissection. Read More

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Does Residual Invasive Disease in Wide Local Excision after Diagnosis with Partial Biopsy Technique Influence Survival in Melanoma? Matched-Pair Analysis of Multicenter Selective Lymphadenectomy Trial I and II.

J Am Coll Surg 2022 Jul 5;235(1):49-59. Epub 2022 May 5.

From Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA.

Background: Current guidelines recommend excisional/complete biopsy for melanoma diagnosis, owing to high rates of residual disease found at wide local excision (WLE) after partial biopsy techniques. We sought to determine any survival disadvantage associated with the presence of residual invasive melanoma in the WLE after diagnosis with a partial biopsy technique.

Study Design: Data were examined from Multicenter Selective Lymphadenectomy Trials I and II (MSLT-I and -II), 2 large melanoma trials. Read More

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Perforators of the Anteromedial Thigh Skin and Possible Design of the Anteromedial Thigh Flap: A Cadaveric Study.

Ann Plast Surg 2022 Jun 11. Epub 2022 Jun 11.

From the Human Anatomy and Embryology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background: Specific perforator-based flaps are a new era in plastic reconstruction. They have replaced many of the traditional paradigms in plastic surgery. The anteromedial thigh flap is a versatile flap that can be used as a primary choice for many reconstructive purposes or as a secondary choice for the anterolateral thigh flap. Read More

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Nationwide multidisciplinary consensus on the clinical management of Merkel cell carcinoma: a Delphi panel.

J Immunother Cancer 2022 Jun;10(6)

Melanoma Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori IRCCS Fondazione "G.Pascale", Napoli, Italy

Merkel cell carcinoma (MCC) is a rare and highly aggressive cutaneous neuroendocrine carcinoma. The MCC incidence rate has rapidly grown over the last years, with Italy showing the highest increase among European countries. This malignancy has been the focus of active scientific research over the last years, focusing mainly on pathogenesis, new therapeutic trials and diagnosis. Read More

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Population-based assessment of sentinel lymph node biopsy in the management of cutaneous melanoma.

Can J Surg 2022 May-Jun;65(3):E394-E403. Epub 2022 Jun 14.

From the University of British Columbia, Vancouver, BC (Ollek, Minkova, Taqi, Chen, Martinka); and the British Columbia Cancer Agency, Vancouver, BC (Davis, Hamilton, Stuart).

Background: Sentinel lymph node biopsy (SLNB) for melanoma plays a central role in determining prognosis and guiding treatment and surveillance strategies. Despite widely published guidelines for SLNB, variation exists in its use. We aimed to determine the frequency of and predictive factors for SLNB in patients with clinically node-negative melanoma in British Columbia. Read More

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Mohs Micrographic Surgery in Squamous Cell Carcinoma of the Nail Unit.

Actas Dermosifiliogr 2022 05 17;113(5):526-528. Epub 2021 Nov 17.

Servicio de Dermatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España.

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Practical Considerations About Optimal Skin Incisions/Excisions in Dermatologic Surgery with Emphasis on Incisions Orientation and Primary Cutaneous Melanoma Surgery.

R Moro E Nagore

Actas Dermosifiliogr 2022 May 31;113(5):491-497. Epub 2022 Jan 31.

Departamento de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

Dermatologic surgery has 2main objectives: 1) to guarantee surgical radicality; and 2) to achieve optimal aesthetic and functional results. These 2paradigms and their hierarchy must be considered when performing surgical procedures on the skin. Even the easiest intervention, the elliptical excision, presents some features that should be known to achieve such goals. Read More

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scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft.

Int J Med Sci 2022 21;19(5):952-964. Epub 2022 May 21.

Department of Burns and Plastic Surgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, P.R. China.

Preventing fibrosis or hypertrophic scar formation following tissue damage is still a big challenge despite the numerous approaches clinicians currently use. Hitherto, no written account was available of a successful case of scarless skin healing after a severe burn injury. Here, we report the first case of the "perfect regenerative healing" of a severe burn wound with no hypertrophic scar formation in which a postage stamp skin autograft was covered with human cytotoxic-T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) gene-transferred pig skin. Read More

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A Comparison of Complication Rates in Wise Pattern Versus Vertical Breast Reduction.

Ann Plast Surg 2022 06;88(5 Suppl 5):S498-S500

Department of Surgery, University of Mississippi Medical Center, Jackson, MS.

Background: Breast reduction has a well-chronicled history and remains a common reason for patients to seek plastic surgery consultation. The Wise pattern is the most common skin reduction pattern in the United States. Vertical pattern reduction is also widely used and offers the potential for decreased scar burden. Read More

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Higher proportions of CD39+ tumor-resident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy.

J Immunother Cancer 2022 Jun;10(6)

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia

Background: Adjuvant immune checkpoint inhibitor (ICI) immunotherapies have significantly reduced the recurrence rate in high-risk patients with stage III melanoma compared with surgery alone. However, 48% of anti-PD-1-treated patients will develop recurrent disease within 4 years. There is a need to identify biomarkers of recurrence after adjuvant ICI to enable identification of patients in need of alternative treatment strategies. Read More

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Cutaneous Melanomas: A Single Center Experience on the Usage of Immunohistochemistry Applied for the Diagnosis.

Int J Mol Sci 2022 May 25;23(11). Epub 2022 May 25.

Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, 40139 Bologna, Italy.

Cutaneous melanoma (cM) is the deadliest of all primary skin cancers. Its prognosis is strongly influenced by the stage at diagnosis, with early stages having a good prognosis and being potentially treatable with surgery alone; advanced stages display a much worse prognosis, with a high rate of recurrence and metastasis. For this reason, the accurate and early diagnosis of cM is crucial-misdiagnosis may have extremely dangerous consequences for the patient and drastically reduce their chances of survival. Read More

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Reconstruction of a fistula in the anterior soft triangle of the nose after basal cells carcinoma excision: A case report.

Int J Surg Case Rep 2022 Jun 18;95:107225. Epub 2022 May 18.

University of Sassari, Department of Medical, Surgical and Experimental Sciences, Sassari University Hospital Trust, Plastic Surgery Unit, Sassari, Italy; University of Sassari, School of Specialization in Plastic, Reconstructive and Aesthetic Surgery. Electronic address:

Introduction And Importance: Basal cell carcinomas represent the most frequent skin cancer and the nose is the most common site of presentation. This has an impact on both aesthetics and function of the nose and consequences in patients' psyche.

Case Presentation: In our paper, the first case in literature of a cutaneous fistula in the nasal soft triangle, after a basal cell carcinoma excision, and its reconstruction, is reported. Read More

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