26,646 results match your criteria Anatomy in Cutaneous Surgery


Loss of CD169 Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma.

Otolaryngol Head Neck Surg 2019 Feb 12:194599819829741. Epub 2019 Feb 12.

1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: The purpose of this study is to assess CD169 expression in metastatic and nearby tumor-free lymph nodes of patients with head and neck squamous cell carcinoma (SCC).

Study Design: Retrospective analysis based on immunohistochemistry.

Setting: Tertiary care center. Read More

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http://dx.doi.org/10.1177/0194599819829741DOI Listing
February 2019

Reptile Embryology and Regeneration.

Methods Mol Biol 2019 ;1920:219-246

Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada.

Reptiles (lizards, snakes, turtles, and crocodilians) are becoming increasingly popular as models for developmental investigations. In this review the leopard gecko, Eublepharis macularius, is presented as a reptilian model for embryonic and tissue regeneration studies. We provide details of husbandry and breeding and discuss aspects of embryonic nutrition, egg anatomy, and sex determination. Read More

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http://dx.doi.org/10.1007/978-1-4939-9009-2_13DOI Listing
January 2019

Anatomical Study of a Chimeric Fascio-Osteomyocutaneous Fibula Flap for Free Microvascular Tissue Transfer.

J Reconstr Microsurg 2019 Jan 31. Epub 2019 Jan 31.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Background:  Functional restoration in reconstructive surgery can require complex and adaptable approaches. In this anatomical study, the combined angiosome of the septofasciomyocutaneous vessels originating from the fibular artery was defined as basis for a chimeric flap of the lateral lower leg.

Methods:  Methylene blue injection into the fibular artery was performed in 10 legs of fresh cadavers for visualization of the angiosome on the skin, fibula, and adjacent muscles as the lateral hemisoleus (HS) muscle. Read More

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http://dx.doi.org/10.1055/s-0039-1677769DOI Listing
January 2019
1 Read

Cutaneous eruptions associated with hematologic malignancies: the need for a unifying nomenclature.

J Eur Acad Dermatol Venereol 2019 Jan 29. Epub 2019 Jan 29.

Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

we read with interest the study by Visseaux et al., entitled "T-cell papulosis associated with B-cell malignancies: a distinctive clinicopathologic entity". Herein, the authors reviewed retrospectively 37 patients with B-cell malignancies, mostly B-cells chronic lymphocytic leukaemia (B-CLL), showing recurrent episodes of pruritic papules, papulo-vesicles or nodules. Read More

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http://dx.doi.org/10.1111/jdv.15452DOI Listing
January 2019
1 Read

Vulvar malignant melanoma: Pathogenesis, clinical behaviour and management: Review of the literature.

Cancer Treat Rev 2019 Feb 24;73:91-103. Epub 2018 Dec 24.

Department of Gynaecology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Vulvar malignant melanoma (VMM) is a rare disease, accounting for 5% of all vulvar malignancies and is characterized by low survival and high recurrence rates. It is considered as a distinct entity of mucosal melanoma. Prognostic factors are higher age, advanced Breslow thickness, and lymph node involvement whilst central localization and ulceration status are still under debate. Read More

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http://dx.doi.org/10.1016/j.ctrv.2018.12.005DOI Listing
February 2019
4 Reads

Free bipaddled anterolateral thigh flap for simultaneous reconstruction of large larynx and prelaryngeal skin defects after resection of the local recurrent laryngeal cancer invading the cricoid cartilage and prelaryngeal skin: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14199

Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Rationale: After total or near-total laryngectomy and resection of prelaryngeal skin, laryngeal defects and prelaryngeal skin defects often remain a great challenge for head and neck surgeons when considering simultaneous reconstruction of. In this case report, a free bipaddled anterolateral thigh (ALT) was used for such defects reconstruction.

Patient Concerns: For this 50-year-old male patient whose recurrent tumor invaded the cricoid cartilage and the prelaryngeal skin, supracricoid partial laryngectomy with a cricohyoidepiglottopexy would no longer be an option. Read More

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http://dx.doi.org/10.1097/MD.0000000000014199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358393PMC
January 2019
1 Read
5.723 Impact Factor

The pecs anesthetic blockade: A correlation between magnetic resonance imaging, ultrasound imaging, reconstructed cross-sectional anatomy and cross-sectional histology.

Clin Anat 2019 Jan 21. Epub 2019 Jan 21.

Department of Functional Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands.

The interfascial thoracic wall blockades Pecs I and Pecs II are increasingly applied in breast and axillary surgery. Despite the clear anatomical demarcations depicted at their introduction, the clinical outcome is more variable than would be expected based upon the described anatomy. In order to elucidate factors that explain this variability, we evaluated the spread of each injection-medial Pecs I, lateral Pecs I, the deep injection of the Pecs II-separately. Read More

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http://dx.doi.org/10.1002/ca.23333DOI Listing
January 2019
1 Read

Droplet digital PCR for detection of mutation in formalin-fixed, paraffin-embedded melanoma tissues: a comparison with Cobas 4800, Sanger sequencing, and allele-specific PCR.

Am J Transl Res 2018 15;10(11):3773-3781. Epub 2018 Nov 15.

Division of Oncology, Slovakia JFM CU, Biomedical Center Martin JFM CU, Jessenius Faculty of Medicine in Martin (JFM CU), Commenius University in Bratislava Mala Hora 4C, 036 01 Martin.

Cutaneous melanoma has the worst prognosis of all skin cancers. Although emerging targeted therapies, such as B-Raf kinase inhibitor vemurafenib, improve prognosis they require an accurate and sensitive means of detecting the pathogenic mutation. We compared the sensitivity of four detection methods in formalin-fixed, paraffin-embedded melanoma biopsies from 87 consecutive melanoma patients with Breslow stage I-V disease (staging based on the depth of tumor of invasion). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291720PMC
November 2018
1 Read

Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas.

Oncotarget 2018 Dec 18;9(99):37291-37304. Epub 2018 Dec 18.

Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Read More

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http://dx.doi.org/10.18632/oncotarget.26458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324666PMC
December 2018

Melanoma types by in vivo reflectance confocal microscopy correlated with protein and molecular genetic alterations: A pilot study.

Exp Dermatol 2019 Jan 12. Epub 2019 Jan 12.

Department of Surgery, Medicine, Dentistry and Morphological Sciences with interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Cutaneous melanoma (CM) is one of the most prevalent skin cancers, which lacks both a prognostic marker and a specific and lasting treatment, due to the complexity of the disease and heterogeneity of patients. Reflectance confocal microscopy (RCM) in vivo analysis is a versatile approach offering immediate morphological information, enabling the identification of four primary cutaneous RCM CM types. Whether RCM CM types are associated with a specific protein and molecular genetic profiles at the tissue level remains unclear. Read More

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http://dx.doi.org/10.1111/exd.13877DOI Listing
January 2019
5 Reads

Ultrasound-guided selective block of the medial brachial cutaneous and the intercostobrachial nerves for proximal arteriovenous fistula surgery.

Reg Anesth Pain Med 2019 Jan 11. Epub 2019 Jan 11.

Department of Anesthesiology, Hospital Clínic, Barcelona, Spain

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http://dx.doi.org/10.1136/rapm-2018-100298DOI Listing
January 2019
2 Reads

Invalid freeze-dried platelet gel promotes wound healing.

Saudi Pharm J 2019 Jan 20;27(1):33-40. Epub 2018 Jul 20.

Siriraj Center of Research Excellence for Molecular Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Wound healing is the curative process of tissue injury, composed of three phases: the inflammatory phase, proliferative phase, followed by the maturation cum remodeling phase. Various treatment options were previously depicted for wound healing, however a treatment that accelerates these phases would be highly valuable. Platelet aggregation at the bleeding vessels and release of various growth factors are the most promising factors that stimulates the wound healing progress. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323128PMC
January 2019
1 Read

Understanding Anatomy of the Petrous Pyramid-A New Compartmental Approach.

World Neurosurg 2019 Jan 5. Epub 2019 Jan 5.

Department of Anatomy, University of Lyon 1, Lyon, France; Skull Base Multi-disciplinary Unit, Department of Neurosurgery B, Neurological Hospital Pierre Wertheimer, Hospices Civils de Lyon, Lyon Cedex, France.

Background: Learning surgical anatomy of the petrous pyramid can be a challenge, especially in the beginning of the training process. Providing an easier, holistic approach can be of help to everyone with interest in learning and teaching skull base anatomy. We present the complex organization of petrous pyramid anatomy using a new compartmental approach that is simple to understand and remember. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183279
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http://dx.doi.org/10.1016/j.wneu.2018.11.234DOI Listing
January 2019
10 Reads

Three-Dimensional Vascular Anatomical Study of the Tensor Fasciae Latae Muscle and Perforators.

J Reconstr Microsurg 2019 Jan 7. Epub 2019 Jan 7.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Dalhousie University, Halifax, Canada.

Background:  To harvest any flap on the lateral circumflex femoral artery (LCFA) including tensor fasciae latae (TFL) muscle, a precise description of the vascular anatomy is required. There have been conflicting reports of the vascular supply of TFL and its overlying skin. The objective of this study was to evaluate the anatomy of the TFL muscle according to the location, origin, type, caliber, and length of vessels that supply the muscle. Read More

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http://dx.doi.org/10.1055/s-0038-1677010DOI Listing
January 2019
6 Reads

TNF-alpha and metalloproteases as key players in melanoma cells aggressiveness.

J Exp Clin Cancer Res 2018 Dec 28;37(1):326. Epub 2018 Dec 28.

Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, ISS, viale Regina Elena 299, 00161, Rome, Italy.

Background: Melanoma aggressiveness determines its growth and metastatic potential. This study aimed at identifying new molecular pathways controlling melanoma cell malignancy.

Methods: Ten metastatic melanoma cell lines were characterized by their proliferation, migration and invasion capabilities. Read More

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http://dx.doi.org/10.1186/s13046-018-0982-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309098PMC
December 2018

"Five-point eight-line" anatomic flap design for precise hemitongue reconstruction.

Head Neck 2018 Dec 17. Epub 2018 Dec 17.

Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Background: Reconstruction of hemiglossectomy defects requires careful flap design to avoid adverse functional and aesthetic outcomes.

Methods: Hemitongue specimens were obtained from minipigs to study the three-dimensional anatomy and to define anatomic landmarks for precise measurements of flap requirement. The concept developed in animal models was then applied to hemiglossectomy reconstruction in clinical practice. Read More

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http://dx.doi.org/10.1002/hed.25571DOI Listing
December 2018
1 Read

Exceptional and Durable Responses to TDM-1 After Trastuzumab Failure for Breast Cancer Skin Metastases: Potential Implications of an Immunological Sanctuary.

Front Oncol 2018 3;8:581. Epub 2018 Dec 3.

Division of Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy.

Breast Cancer (BC) skin metastases represent a challenging clinical scenario. Although they usually arise when other distant metastases are already present, they may also represent a form of locoregional recurrence (LRR). Systemic therapy in this setting may have a role both in case a radical locoregional approach is unfeasible in order to achieve disease control, and as adjuvant strategy after radical removal of cutaneous lesions, in order to prevent or delay subsequent disease spread. Read More

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http://dx.doi.org/10.3389/fonc.2018.00581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287048PMC
December 2018
1 Read

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma.

J Exp Clin Cancer Res 2018 Dec 17;37(1):318. Epub 2018 Dec 17.

Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.

Background: Combination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved in these long-term treatment failures. We previously reported in lung cancer that CSCs maintenance is due to altered lipid metabolism and dependent upon Stearoyl-CoA-desaturase (SCD1)-mediated upregulation of YAP and TAZ. Read More

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http://dx.doi.org/10.1186/s13046-018-0989-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298024PMC
December 2018
1 Read

The clinicopathologic impacts and prognostic significance of GLUT1 expression in patients with lung cancer: A meta-analysis.

Gene 2019 Mar 12;689:76-83. Epub 2018 Dec 12.

Department of Thoracic Oncology, First Affiliated Hospital of Xi'an Medical University, Xi'an 710032, Shaanxi Province, PR China. Electronic address:

Background: Accumulating studies have reported that GLUT1 is aberrantly expressed in lung cancer; nevertheless, the clinicopathologic significance and the prognostic role of GLUT1 still remain controversial. The aim of this meta-analysis was to identify the clinicopathologic and prognostic implications of the GLUT1 expression in lung cancer patients.

Materials And Methods: Databases with literature published in English, including Cochrane Library, Embase, Web of Science, and PubMed, and the China National Knowledge Infrastructure (CNKI) and WanFang database in Chinese were searched comprehensively for relevant studies in August 2017. Read More

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http://dx.doi.org/10.1016/j.gene.2018.12.006DOI Listing
March 2019
2 Reads

T cell-lymphoma in the eyelid of a 9-year-old English Setter.

Acta Vet Scand 2018 Dec 6;60(1):79. Epub 2018 Dec 6.

Eye Pathology Section, Department of Pathology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Frederik V's Vej, 11, 1st Floor, 2100, Copenhagen Ø, Denmark.

Background: Eyelid tumours are frequently found in dogs, most of these being benign. In case of an ulcerating eyelid tumour, malignancy must be considered. We report a unique case of a low-grade peripheral T-cell lymphoma in the eyelid of a 9-year-old English Setter. Read More

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http://dx.doi.org/10.1186/s13028-018-0432-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284267PMC
December 2018
4 Reads

Evaluation of levels of interleukin-6, interleukin-8 and some haematologic parameters of dogs with cutaneous wounds.

Cytokine 2019 Jan 28;113:128-138. Epub 2018 Jun 28.

Department of Veterinary Medicine, ABU, Zaria, Nigeria.

The aim of the study was to investigate the time-course of serum and wound fluids interleukin (IL)-6 and IL-8 levels in dogs with cutaneous wounds and their relationship with some haematologic parameters. The experimental group comprised of six adult dogs that underwent surgery with wounds (n = 6) on the mid lateral aspect of the right antebrachium; and control group of six, apparently, healthy intact (free from cutaneous wounds) adult dogs, comprising equal number of both sexes. Vital signs evaluated were within normal limits. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.06.024DOI Listing
January 2019
3 Reads

Mixed (nodular and morpheic) upper eyelid basal cell carcinoma with orbital invasion - histological and clinical features.

Rom J Morphol Embryol 2018 ;59(3):977-983

Department of Plastic Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

Basal cell carcinoma (BCC) is the most common type of cancer located in the periocular area. We will present the clinical case of a 63-year-old male patient who was admitted to the 2nd Clinic of Neurosurgery, "Prof. Dr. Read More

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January 2019
6 Reads

Identification of a robust methylation classifier for cutaneous melanoma diagnosis.

J Invest Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, NC; Lineberger Comprehensive Cancer Center (LCCC), University of North Carolina at Chapel Hill, Chapel Hill, NC.

Early diagnosis improves melanoma survival, yet the histopathological diagnosis of cutaneous primary melanoma can be challenging even for expert dermatopathologists. Analysis of epigenetic alterations, such as DNA methylation, that occur in melanoma can aid in its early diagnosis. Using a genome-wide methylation screen, we assessed CpG methylation in a diverse set of 89 primary invasive melanomas, 73 nevi, and 41 melanocytic proliferations of uncertain malignant potential, classified based on interobserver review by dermatopathologists. Read More

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http://dx.doi.org/10.1016/j.jid.2018.11.024DOI Listing
December 2018
1 Read
7.216 Impact Factor

A Comparative Study of the Reverse Sural Fascio-Cutaneous Flap Outcomes in the Management of Foot and Ankle Soft Tissue Defects in Diabetic and Trauma Patients.

Foot Ankle Spec 2018 Dec 7:1938640018816378. Epub 2018 Dec 7.

Department of Orthopedic Surgery, Lebanese American Hospital Medical Center-Rizk Hospital, Beirut, Lebanon (CA, CS, TH, KY), Center for Evidence-based Anatomy, Sports and Orthopedic Research, Beirut, Lebanon.

Introduction: Soft tissue defects in the distal leg and foot are challenging conditions for reconstruction. The widely used reverse sural fascio-cutaneous flap (RSFCF) has been reported with large variation in complication frequency. Some authors reported higher complications in the diabetic population when compared with trauma patients. Read More

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http://dx.doi.org/10.1177/1938640018816378DOI Listing
December 2018
1 Read

Medical Castration is a Rare but Possible Trigger of Torsade de Pointes and Ventricular Fibrillation.

Int Heart J 2019 Jan 5;60(1):193-198. Epub 2018 Dec 5.

Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui.

Prostate cancer is the most common non-cutaneous malignancy in men and has been steadily rising in an aging society. Medical castration therapy is effective for metastatic prostate cancer, but the proarrhythmic properties have not been reported. We present a 71-year-old Japanese man with metastasis prostate cancer that, during medical castration therapy, had torsades de pointes (TdP) with a QT prolongation and ventricular fibrillation (VF). Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-127DOI Listing
January 2019
5 Reads

Surgical anatomy of the dorsal cutaneous branch of the ulnar nerve and its clinical significance in surgery at the ulnar side of the wrist.

J Hand Surg Eur Vol 2018 Dec 5:1753193418815800. Epub 2018 Dec 5.

Upper Extremity and Reconstructive Microsurgery Unit, Institute of Orthopaedics, Lerdsin General Hospital, Department of Orthopaedic Surgery, College of Medicine, Rangsit University, Bangkok, Thailand.

The dorsal cutaneous branch of the ulnar nerve can be easily injured during surgery at the ulnar side of the wrist. We sought to identify the surgical anatomy, the pathway around the ulnar styloid process and the safe zone of the dorsal cutaneous branch of the ulnar nerve. In 44 forearm dissections, we found that the dorsal cutaneous branch of the ulnar nerve originated at a median distance of 6. Read More

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http://journals.sagepub.com/doi/10.1177/1753193418815800
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http://dx.doi.org/10.1177/1753193418815800DOI Listing
December 2018
15 Reads

Healing effect of andiroba-based emulsion in cutaneous wound healing via modulation of inflammation and transforming growth factor beta 31.

Acta Cir Bras 2018 Nov;33(11):1000-1015

MD, Postgraduate Program in Surgical Science, Department of Surgery, School of Medicine, UFRJ, Rio de Janeiro-RJ, Brazil. Manuscript writing, critical revision, final approval.

Purpose: To evaluate the effects and mechanisms of andiroba-based emulsion (ABE) topical treatment on full-thickness cutaneous wounds in rats.

Methods: The wounds were harvested on days 3, 7, 15, and 20 post-surgery. Wound contraction rate, quantitative immunohistochemistry [macrophages, myofibroblasts, capillaries, collagens (col) I and III, transforming growth factor β3β (TGFβ3)], and tensile strength were assessed. Read More

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http://dx.doi.org/10.1590/s0102-865020180110000007DOI Listing
November 2018
11 Reads

Anatomy of the Superficial Fascia System of the Breast: A Comprehensive Theory of Breast Fascial Anatomy.

Plast Reconstr Surg 2018 Nov;142(5):1135-1144

St. Petersburg and Bradenton, Fla.; and Lynchburg, Va. From plastic surgery private practice; OMS-II, Lake Erie College of Osteopathic Medicine; general surgery private practice; and general medicine private practice.

Background: It has been two centuries since Petrus Camper identified superficial fascia and over 175 years since Sir Astley Cooper wrote his book on the anatomy of the breast. In the 1990s, Ted Lockwood taught us the importance of the superficial fascia layers in body contouring procedures he pioneered. These descriptions, however, fail to explain the three-dimensional fascial system in the breast. Read More

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http://dx.doi.org/10.1097/PRS.0000000000004948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211786PMC
November 2018
3 Reads

Combination of meshed dermis graft and cultured epithelial autograft for massive burns: Three case reports.

Medicine (Baltimore) 2018 Nov;97(48):e13313

Department of Plastic Surgery, Gunma Children's Medical Center, Gunma, Japan.

Rationale: This study reviewed the use of a combination of meshed dermis graft and cultured epithelial autografts (CEA) made in Japan "JACE" (JACE; Japan Tissue Engineering Co., Ltd. Japan) for the treatment of massively burns. Read More

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http://dx.doi.org/10.1097/MD.0000000000013313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283229PMC
November 2018
3 Reads

Conjunctival Colloid Milium.

Cornea 2019 Mar;38(3):386-387

Department of Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: To describe a rare case of conjunctival colloid milium.

Methods: Case report.

Results: We report a 45-year-old woman with a history of a slow-growing, painless mass extending from the medial canthal region to the inferior fornix and the inferior bulbar conjunctiva associated with redness. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001824DOI Listing
March 2019
5 Reads

Trehalose inhibits cell proliferation and amplifies long-term temozolomide- and radiation-induced cytotoxicity in melanoma cells: A role for autophagy and premature senescence.

J Cell Physiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

Cutaneous melanomas frequently metastasize to the brain, with temozolomide (TMZ) plus radiotherapy (RT) offering little control of these lesions. We tested whether trehalose, a natural glucose disaccharide proved to induce autophagy, could enhance the effect of TMZ and ionizing radiation (IR). In two melanoma cell lines (A375 and SK-Mel-28), which greatly differ in chemosensitivity and radiosensitivity, trehalose significantly inhibited short-term cell proliferation and also enhanced IR-induced cytostasis. Read More

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http://dx.doi.org/10.1002/jcp.27838DOI Listing
November 2018
1 Read

Dermoscopy of squamoid eccrine ductal carcinoma: an aid for early diagnosis.

An Bras Dermatol 2018 Nov/Dec;93(6):893-895

Dermatology Service, Hospital do Servidor Público Estadual de São Paulo, São Paulo (SP), Brazil.

Squamoid eccrine ductal carcinoma is a cutaneous malignancy that originates from the eccrine sweat gland. A 76-year-old woman presented with an asymptomatic papule on her nose that had been present for one year. Dermoscopy showed pseudocysts, irregular linear crown vessels, and yellowish-brown globules surrounded by white halos. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/abd1806-4841.20187307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256200PMC
February 2019
4 Reads

Lokivetmab therapy for pruritus in a dog with cutaneous mastocytosis.

Vet Dermatol 2019 Feb 26;30(1):73-e22. Epub 2018 Nov 26.

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, GA, 30602, USA.

Background: Cutaneous mastocytosis (CM) is a rare disease of dogs characterized by rash, pruritus and proliferation of mast cells in the skin. Oral H1 antihistamines are recommended as the treatment to control pruritus.

Hypothesis/objective: To describe the effective treatment of pruritus associated with CM with lokivetmab in one dog. Read More

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http://doi.wiley.com/10.1111/vde.12702
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http://dx.doi.org/10.1111/vde.12702DOI Listing
February 2019
13 Reads

Prognostic importance of mitochondrial markers in mucosal and cutaneous head and neck melanomas.

Hum Pathol 2018 Nov 20. Epub 2018 Nov 20.

Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

Mitochondrial dysfunction is caused by an imbalance in the fission and fusion processes, and it has been implicated in the pathogenesis of several human cancers. However, the role of mitochondrial markers in melanomas still remain poorly understood. In this study, the authors assessed the expression of three mitochondrial markers [antimitochondrial (AMT), fission protein 1 (FIS1) and mitofusin 2 (MFN2)] in a series of head and neck mucosal and cutaneous melanomas. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.009DOI Listing
November 2018
2 Reads

Defect Reconstruction of an Infected Diabetic Foot Using Split- and Full-thickness Skin Grafts With Adjuvant Negative Pressure Wound Therapy: A Case Report and Review of the Literature.

Wounds 2018 Nov;30(11):E108-E115

University Hospital Rebro, Department of Plastic, Reconstructive and Aesthetic Surgery, Zagreb, Croatia.

Introduction: Any alteration or impairment to normal wound healing can result in the development of chronic wounds, which may lead to serious complications such as infection and loss of body fluid and proteins. Primary closure alone may not be sufficient to fulfill the criteria of successful defect reconstruction. Therefore, additional procedures such as skin grafting must be considered as an option. Read More

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November 2018
6 Reads

Prognostic impact of regression in patients with primary cutaneous melanoma >1 mm in thickness.

J Am Acad Dermatol 2019 Jan 14;80(1):99-105.e5. Epub 2018 Nov 14.

Unit of Medical Oncology, Papa Giovanni XXIII Hospital, Bergamo, Italy. Electronic address:

Background: The impact of histologic regression on sentinel lymph node biopsy (SLNB) status and on clinical outcome is uncertain.

Objective: To investigate whether and to what extent regression <75% is able to predict SLNB status and clinical outcome of patients with melanoma >1-mm thick.

Methods: The study included patients with diagnoses given at 4 centers of the Italian Melanoma Intergroup. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183221
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http://dx.doi.org/10.1016/j.jaad.2018.06.054DOI Listing
January 2019
12 Reads
4.450 Impact Factor

The hemodynamic and molecular mechanism study on the choke vessels in the multi-territory perforator flap transforming into true anastomosis.

Gene 2019 Mar 15;687:99-108. Epub 2018 Nov 15.

Department of Hand and Microsurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China. Electronic address:

Background: The aim of this study was to explore the hemodynamic and morphological changes of the choke vessels, and to investigate the role of HIF-1α in the flap adaptation to hypoxic and choke vessel transformation after multi-territory perforator flap transplantation.

Methods: Animal model of single pedicle multi-territory perforator flap was established in the back of SD rats and the blood supply characteristics were studied by gelatin-oxide perfusion technique. HE staining and stereomicroscope were used to observe vascular changes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119183116
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http://dx.doi.org/10.1016/j.gene.2018.11.019DOI Listing
March 2019
10 Reads

Cadaveric Dissection of the Axillary Nerve: An Investigation of Extra-Muscular and Intra-Muscular Branching Patterns.

J Hand Surg Asian Pac Vol 2018 Dec;23(4):533-538

1 Department of Hand Surgery and Peripheral Nerve Surgery, Royal North Shore Hospital (Northern Sydney Local Health District), University of Sydney, Sydney, Australia.

Background: Variations in the axillary nerve branching patterns have been reported. The aim of the study is to investigate the extra- and intra-muscular course of the axillary nerve and quantify the regional innervation of the deltoid.

Methods: In fresh frozen specimens, the origin of the axillary nerve from the posterior cord of the brachial plexus and its extra- and intra-muscular course were identified. Read More

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http://dx.doi.org/10.1142/S2424835518500546DOI Listing
December 2018
9 Reads

Phantom Sensation-Underreported Sensory Outcome Following Intercostal-to-Musculocutaneous Nerve Transfer.

World Neurosurg 2019 Feb 9;122:303-307. Epub 2018 Nov 9.

School of Medicine, Emory University, Atlanta, Georgia, USA; Department of Neurosurgery, Emory University, Atlanta, Georgia, USA.

Background: Intercostal-to-musculocutaneous nerve transfer is commonly performed in patients with brachial plexus avulsion injuries. As techniques have improved since its inception in 1963, most patients now experience some level of motor function improvement of their affected arm. While motor outcomes are well described, there is a paucity of literature describing sensory outcomes. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.216DOI Listing
February 2019
2 Reads

Lamellar rotation surgery: a new procedure for repairing upper eyelid defects.

Authors:
Qingji Li

BMC Ophthalmol 2018 Nov 7;18(1):291. Epub 2018 Nov 7.

Department of Oculoplastic and Reconstructive Surgery, Tianjin Aier Eye Hospital, No.102, Fukang Road, Nankai District, Tianjin, 300190, People's Republic of China.

Background: To report "Lamellar Rotation Surgery",a new technique for repairing large and moderate full-thickness upper eyelid defects.

Methods: A two-stage technique is described in which a vertical incision is made in the tarsus of the lower eyelid with elevation of the lateral posterior lamella while sparing the lower eyelid orbicularis and skin to be rotated superiorly to form the reconstructed posterior lamella of the upper eyelid. Additionally, a lateral periosteal flap is used to reconstruct the lateral canthal tendon, and a McGregor procedure is used to reconstruct the anterior lamella of the upper eyelid. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0958-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222999PMC
November 2018
9 Reads

Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis.

Neoplasia 2018 12 4;20(12):1198-1208. Epub 2018 Nov 4.

Department of Surgery, Regensburg University Hospital, Franz-Josef-Strauss Allee 9, Regensburg, Germany; Department of General and Visceral Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, Germany. Electronic address:

Mammalian target of rapamycin complex 2 (mTORC2) with its pivotal component rapamycin-insensitive companion of mTOR (RICTOR) is the major regulator of AKT phosphorylation and is increasingly implicated in tumor growth and progression. In cutaneous melanoma, an extremely aggressive and highly metastatic disease, RICTOR overexpression is involved in tumor development and invasiveness. Therefore, we investigated the impact of RICTOR inhibition in melanoma cells in vitro and in vivo with special emphasis on hepatic metastasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14765586183036
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http://dx.doi.org/10.1016/j.neo.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224335PMC
December 2018
11 Reads

Risk Factors for Regional and Systemic Metastases in Patients with Sentinel Lymph Node-negative Melanoma.

Anticancer Res 2018 Nov;38(11):6571-6577

Department of Surgery, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: Sentinel lymph node status is a strong prognostic factor in melanoma. However, up to 21% of sentinel lymph node-negative patients develop locoregional and distant metastases during follow-up.

Aim: To analyze risk factors for locoregional and distant metastasis in patients with sentinel lymph node-negative melanoma. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13024DOI Listing
November 2018
11 Reads

Long-term Survival of Stage IV Melanoma Patients Treated with BOLD Combination Chemotherapy and Intermediate-dose Subcutaneous Interferon-alpha.

Anticancer Res 2018 Nov;38(11):6393-6397

Department of Oncology and Radiotherapy, University of Turku and Turku University Hospital and FICAN West Cancer Centre, Turku, Finland.

Background: Immune checkpoint and serine/threonine-protein kinase inhibitors have become a standard of care for advanced cutaneous melanoma, but dacarbazine-based chemotherapies are occasionally used. This study assessed the long-term efficacy of chemoimmunotherapy (bleomycin, vincristine, lomustine and dacarbazine with/without subcutaneous interferon-alpha: BOLD-INF-α) as real-world data in patients with metastatic melanoma not eligible for clinical trials.

Patients And Methods: Medical data of 146 patients with stage IV melanoma who had received BOLD/BOLD-INFα regimen during 1991-2010 were analyzed. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.12
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http://dx.doi.org/10.21873/anticanres.12999DOI Listing
November 2018
13 Reads

Probable cutaneous loxoscelism with mild systemic symptoms: A case report from Spain.

Toxicon 2018 Dec 2;156:7-12. Epub 2018 Nov 2.

Head of the Unit of Infectious Diseases, University and Polytechnic Hospital La Fe, Avinguda de Fernando Abril Martorell 106, 46026, Valencia, Spain.

We present a case from Valencia, Spain, of a 25-year-old woman who presented with a painful erythematous skin lesion, initially diagnosed as cellulitis. The lesion was unresponsive to antibiotic treatments and progressed into a hemorrhagic blister with necrotic ulcer formation. Posterior collection of a spider from the patient's home and expert identification of the spider as Loxosceles rufescens was achieved, establishing the diagnosis of probable cutaneous loxoscelism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183071
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http://dx.doi.org/10.1016/j.toxicon.2018.10.304DOI Listing
December 2018
5 Reads

Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate.

J Zhejiang Univ Sci B 2018 Nov.;19(11):853-862

Department of Plastic Surgery, Peking Union Medical College Hospital, Beijing 100730, China.

Objective: Keloids are exuberant cutaneous scars that form due to abnormal growth of fibrous tissue following an injury. The primary aim of this study was to assess the efficacy and mechanism of hyperbaric oxygen therapy (HBOT) to reduce the keloid recurrence rate after surgical excision and radiotherapy.

Methods: (1) A total of 240 patients were randomly divided into two groups. Read More

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http://dx.doi.org/10.1631/jzus.B1800132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238115PMC
February 2019
27 Reads

Matrix composition in 3-D collagenous bioscaffolds modulates the survival and angiogenic phenotype of human chronic wound dermal fibroblasts.

Acta Biomater 2019 Jan 29;83:199-210. Epub 2018 Oct 29.

Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond St, London, Ontario N6A 5C1, Canada; Department of Chemical and Biochemical Engineering, Thompson Engineering Building, The University of Western Ontario, London, ON N6A 5B9, Canada. Electronic address:

There is a substantial need for new strategies to stimulate cutaneous tissue repair in the treatment of chronic wounds. To address this challenge, our team is developing modular biomaterials termed "bead foams", comprised of porous beads synthesized exclusively of extracellular matrix (ECM) and assembled into a cohesive three-dimensional (3-D) network. In the current study, bead foams were fabricated from human decellularized adipose tissue (DAT) or commercially-sourced bovine tendon collagen (COL) to explore the effects of ECM composition on human wound edge dermal fibroblasts (weDF) sourced from chronic wound tissues. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183064
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http://dx.doi.org/10.1016/j.actbio.2018.10.042DOI Listing
January 2019
8 Reads

In vitro artificial skin engineering by decellularized placental scaffold for secondary skin problems of meningomyelocele.

J Clin Neurosci 2019 Jan 29;59:291-297. Epub 2018 Oct 29.

Bahçeşehir University, Faculty of Medicine, Turkey.

Background: Meningomyelocele (MMC) is a condition that is originated by the fusion defect of the neural tube. It is a congenital anomaly and can be characterized by spinal cord defects and impaired skin integrity. It is very important to close the skin openings via three-dimensional artificial skin like construction for preventing infection and maintaining the healthy skin structure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183086
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http://dx.doi.org/10.1016/j.jocn.2018.10.044DOI Listing
January 2019
9 Reads

Laparoscopic pancreaticoduodenectomy for metastatic pancreatic melanoma: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e12940

Second Hospital of Hebei Medical University, Shijiazhuang.

Rationale: Pancreatic metastases from other malignant tumors are an uncommon clinical condition and account for approximately 2% of all pancreatic malignancies. The most common primary malignancy that metastasizes to pancreas is renal cell cancer. We reported a rare clinical case of metastatic melanoma to pancreas who underwent a successful laparoscopic pancreaticoduodenectomy (LPD) at our department. Read More

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http://dx.doi.org/10.1097/MD.0000000000012940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221747PMC
November 2018
8 Reads

[A Case of Myocardial and Cutaneous Metastases of Squamous Cell Lung Cancer Post Left Pneumonectomy and Radical Surgery for Cutaneous Metastasis during Nivolumab Therapy].

Gan To Kagaku Ryoho 2018 Oct;45(10):1441-1444

Dept. of General Thoracic Surgery, Nihonkai General Hospital.

Background: Concomitant myocardial and cutaneous metastases of squamous cell lung cancer after left pneumonectomy are very rare. Although nivolumab is used as a standard second-line chemotherapy for non-small cell lung cancer(NSCLC), its efficacy for concomitant myocardial and cutaneous metastases remains unclear.

Case: A 66-year-old man with no chief complaints was diagnosed with myocardial metastasis by CT scan. Read More

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October 2018
1 Read