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    Anatomical etiology of "pseudo-sciatica" from superior cluneal nerve entrapment: a laboratory investigation.
    J Pain Res 2017 1;10:2539-2545. Epub 2017 Nov 1.
    Department of Anatomy, Tokyo Medical University, Tokyo, Japan.
    Objective: The superior cluneal nerve (SCN) may become entrapped where it pierces the thoracolumbar fascia over the iliac crest; this can cause low back pain (LBP) and referred pain radiating into the posterior thigh, calf, and occasionally the foot, producing the condition known as "pseudo-sciatica." Because the SCN was thought to be a cutaneous branch of the lumbar dorsal rami, originating from the dorsal roots of L1-L3, previous anatomical studies failed to explain why SCN causes "pseudo-sciatica". The purpose of the present anatomical study was to better elucidate the anatomy and improve the understanding of "pseudo-sciatica" from SCN entrapment. Read More

    Clinicopathological predictors of recurrence in nodular and superficial spreading cutaneous melanoma: a multivariate analysis of 214 cases.
    J Transl Med 2017 Nov 7;15(1):227. Epub 2017 Nov 7.
    Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Sassari, Italy.
    Background: Nodular melanoma (NM) accounts for most thick melanomas and because of their frequent association with ulceration, fast growth rate and high mitotic rate, contribute substantially to melanoma-related mortality. In a multicentric series of 214 primary melanomas including 96 NM and 118 superficial spreading melanoma (SSM), histopathological features were examined with the aim to identify clinicopathological predictors of recurrence.

    Methods: All consecutive cases of histopathologically diagnosed primary invasive SSM and NM during the period 2005-2010, were retrieved from the 12 participating Italian Melanoma Intergroup (IMI) centers. Read More

    The structure of the cutaneous pedal glands in the banded snail Cepaea hortensis (Müller, 1774).
    J Morphol 2017 Nov 3. Epub 2017 Nov 3.
    Faculty of Life Science, Core Facility Cell Imaging and Ultrastructure Research, University of Vienna, Vienna, Austria.
    Although gastropods have been crawling through the ocean and on the land for 60 million years, we still know very little about the sticky mucus produced in their foot. Most research has been focused on marine species in particular and, to a lesser extent, on the well-known terrestrial species Arion vulgaris and Cornu aspersum. Within this study, we aim to characterize the foot anatomy of a smaller representative of the family Helicidae, the banded snail Cepaea hortensis. Read More

    Glucagonoma syndrome with serous oligocystic adenoma: A rare case report.
    Medicine (Baltimore) 2017 Oct;96(43):e8448
    aDiabetic Foot Center, Department of Endocrinology and Metabolism bDepartment of Pathology cDepartment of Pancreatic Surgery dDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
    Rationale: Glucagonoma and pancreatic serous oligocystic adenoma (SOA) are rare neuroendocrine and exocrine tumors of the pancreas, respectively. The coexistence of glucagonoma syndrome (GS) and SOA is a rare clinical condition and has not yet been reported. Additionally, necrolytic migratory erythema (NME), a hallmark clinical sign of GS, is often misdiagnosed as other skin lesions by clinicians due to their lack of related knowledge, which delays diagnosis of GS and thus exacerbates the prognosis. Read More

    Eyelid Reconstruction.
    Plast Reconstr Surg 2017 Nov;140(5):724e-735e
    Houston, Texas From the Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center.
    Learning Objectives: After reading this article, the participant should be able to: 1. Describe eyelid anatomy and demonstrate full understanding of the critical structures and basic principles of eyelid reconstruction. 2. Read More

    Optimizing Male Periorbital Rejuvenation.
    Dermatol Surg 2017 Nov;43 Suppl 2:S196-S202
    *Charlotte Plastic Surgery, Charlotte, North Carolina; †Hofstra University Northwell School of Medicine, New York, New York; ‡Dallas Plastic Surgery Institute, Dallas, Texas.
    Background: Facial rejuvenation continues to be an increasing trend among males. The periorbital region deserves special mention given the overall differences in aesthetics between sexes.

    Objective: To examine the aesthetics of the upper eyelid, lower eyelid, lateral canthus, and brow with respect to male periorbital rejuvenation. Read More

    New Drug Combination Strategies in Melanoma: Current Status and Future Directions.
    Anticancer Res 2017 11;37(11):5941-5953
    Laboratory of Oncology and Experimental Surgery Institute Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium
    Melanoma is the deadliest form of skin cancer and one of the most difficult cancers to treat. Overall, melanomas have more mutations than any other cancer type. Oncogenic mutations in c-KIT, NRAS and BRAF components of the MAPK pathway have been identified in nearly 90% of cutaneous melanoma and this information has been used to develop small molecules that inhibit their activity. Read More

    Inhibition of apoptosis signal-regulating kinase 1 alters the wound epidermis and enhances auricular cartilage regeneration.
    PLoS One 2017 18;12(10):e0185803. Epub 2017 Oct 18.
    Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States of America.
    Why regeneration does not occur in mammals remains elusive. In lower vertebrates, epimorphic regeneration of the limb is directed by the wound epidermis, which controls blastema formation to promote regrowth of the appendage. Herein, we report that knockout (KO) or inhibition of Apoptosis Signal-regulated Kinase-1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), after full thickness ear punch in mice prolongs keratinocyte activation within the wound epidermis and promotes regeneration of auricular cartilage. Read More

    Superficial temporal artery perforator flap: Anatomic study of number and reliability of distal branches of the superficial temporal artery and clinical applications in three cases.
    Microsurgery 2017 Nov 16;37(8):924-929. Epub 2017 Oct 16.
    Unit of Plastic Surgery and Dermatology, Campus Bio-Medico University, Via Alvaro del Portillo, 200, Rome 00128, Italy.
    Background: Limited information is available about the anatomical feasibility and clinical applications of flaps based on distal divisions of the superficial temporal artery (STA). The aim of this study was to investigate the anatomy of the STA, focusing on the number and reliability of distal branches and to show representative cases for the use of such flaps for zygomatic, parieto-frontal and occipital reconstructions.

    Methods: Fifty volunteers were examined bilaterally by Doppler to investigate the presence and variability of the distal divisions of STA branches. Read More

    Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual.
    CA Cancer J Clin 2017 Nov 13;67(6):472-492. Epub 2017 Oct 13.
    Professor of Melanoma and Surgical Oncology, Melanoma Institute Australia, The University of Sydney and Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
    Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses of this new database, the existing seventh edition AJCC stage IV database, and contemporary clinical trial data, the AJCC Melanoma Expert Panel introduced several important changes to the Tumor, Nodes, Metastasis (TNM) classification and stage grouping criteria. Key changes in the eighth edition AJCC Cancer Staging Manual include: 1) tumor thickness measurements to be recorded to the nearest 0. Read More

    Variations in the Anatomical Structures of the Guyon Canal.
    Plast Surg (Oakv) 2017 May 30;25(2):84-92. Epub 2017 Mar 30.
    Division of Plastic Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
    Background: Compression neuropathy of the ulnar nerve at the Guyon canal is commonly seen by hand surgeons. Different anatomical variations of structures related to the Guyon canal have been reported in the literature. A thorough knowledge of the normal contents and possible variations is essential during surgery and exploration. Read More

    Anatomy of the vasculature of the lower leg and harvest of a fibular flap: a systematic review.
    Br J Oral Maxillofac Surg 2017 Nov 9;55(9):904-910. Epub 2017 Oct 9.
    Department of Oral & Maxillofacial Surgery, St. Richard's Hospital, Western Sussex Hospitals NHS Foundation Trust, Chichester PO19 6SE, UK. Electronic address:
    The fibular free flap (FFF) is based on the peroneal artery, which has a consistent anatomy and makes a minimal contribution to the pedal circulation. However, certain anatomical variations in the vasculature of the leg might leave the peroneal artery with a major role in the perfusion of the foot, and to raise a FFF could lead to ischaemic complications. Our aim was to review the implications of anatomical variants on planning and harvest of a FFF. Read More

    Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy.
    Brain 2017 Oct;140(10):2557-2569
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
    Non-freezing cold injury develops after sustained exposure to cold temperatures, resulting in tissue cooling but not freezing. This can result in persistent sensory disturbance of the hands and feet including numbness, paraesthesia and chronic pain. Both vascular and neurological aetiologies of this pain have been suggested but remain unproven. Read More

    The Functional Angiosome: Clinical Implications of the Anatomical Concept.
    Plast Reconstr Surg 2017 Oct;140(4):721-733
    Parkville, Victoria, Australia From the Taylor Lab, Department of Anatomy and Neuroscience, and the Royal Melbourne Hospital Department of Surgery, University of Melbourne.
    Background: The angiosome is a three-dimensional block of tissue supplied by a source vessel with its boundary outlined either by an anastomotic perimeter of reduced-caliber choke vessels or by true anastomoses with no reduction of vessel caliber. This article focuses on the role of these anastomotic vessels in defining flap survival or the necrotic pattern seen in fulminating meningococcal septicemia.

    Methods: Experiments in pigs, dogs, guinea pigs, and rabbits over the past 46 years were reviewed, focusing on the necrosis line of flaps, the effects of various toxins in vivo, and correlating these results in the clinical setting. Read More

    Facial Assessment and Injection Guide for Botulinum Toxin and Injectable Hyaluronic Acid Fillers: Focus on the Midface.
    Plast Reconstr Surg 2017 Oct;140(4):540e-550e
    São Paulo, Brazil; Aalst, Belgium; Rio de Janeiro, Brazil; and Dallas, Texas From the Clinica Dr. Maurício de Maio; the Aalst Dermatology Clinic, private practice; and the University of Texas Southwestern Medical Center.
    This second article of a three-part series addresses techniques and recommendations for aesthetic treatment of the midface. Injectable fillers are important for rejuvenation of the midface by replacing lost volume and providing structural support; neuromodulators play a smaller role in this facial region. Fillers are used for volumization and contouring of the midface regions, including the upper cheek and lid-cheek junction and the submalar and preauricular areas. Read More

    Modification of fasciocutaneous radial forearm free flap to achieve two-layer closure during reconstruction of circumferential hypopharyngeal defects.
    Eur Ann Otorhinolaryngol Head Neck Dis 2017 Sep 21. Epub 2017 Sep 21.
    Department of Ear Nose and Throat, Manchester Head and Neck Cancer Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
    Circumferential defects of the hypopharynx are a reconstructive challenge. Various local, regional and free flaps have been described with each having advantages and disadvantages in terms of functional outcomes. The fasciocutaneous radial forearm free flap (RFFF) is one of the most common free flaps used for reconstructing circumferential hypopharyngeal defects. Read More

    Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and wound re-epithelialization in human skin.
    Exp Dermatol 2017 Sep 23. Epub 2017 Sep 23.
    Institute of Anatomy, University of Luebeck, Luebeck, Germany.
    Previous reports have demonstrated that cell-derived nanoparticles (CDNPs) composed of bovine or porcine protein complexes exerted therapeutic effects against viral infections and cancer in mice and humans. Based on these observations, we asked whether CDNPs would improve inflammatory skin disorders. To address this, we utilized two distinct mouse models of cutaneous inflammation: the autoimmune skin-blistering disease epidermolysis bullosa acquisita (EBA) as an example of an autoantibody-induced cutaneous inflammation, and Leishmania major (L. Read More

    Lichen Planus triggered by infliximab biosimilar CT-P13 and recurred during secukinumab treatment.
    Br J Dermatol 2017 Sep 22. Epub 2017 Sep 22.
    Dermatology Unit, Department of Surgical and Translational Medicine, University of Florence.
    we read with interest the manuscript published by Gonzales et al,(1) highlighting lichenoid reactions as an emerging side effect of biologics, with special regard to infliximab-biosimilar. We recently observed a 50-year-old male patient with a long-standing history of moderate-to-severe psoriasis, who developed oral lichen planus (LP) triggered by infliximab biosimilar CT-P13. Interestingly the same patient experienced cutaneous and oral LP when treated with IL-17A blocker, secukinumab. Read More

    A matter of margins: Surgical and pathologic risk factors for recurrence in extramammary Paget's disease.
    Gynecol Oncol 2017 Nov 19;147(2):358-363. Epub 2017 Sep 19.
    Mayo Clinic, Division of Gynecologic Oncology, United States.
    Objectives: To determine surgical and pathologic variables associated with recurrence in extramammary Paget's disease (EMPD).

    Methods: Medical records of patients seeking care for EMPD from 1/1992-9/2015 were reviewed. Follow-up was restricted to 5years following primary surgery. Read More

    Cutaneous melanoma: an audit of management timeliness against New Zealand guidelines.
    N Z Med J 2017 Sep 22;130(1462):54-61. Epub 2017 Sep 22.
    Regional Cancer Centre, Waikato District Health Board, Hamilton.
    Aim: The New Zealand Ministry of Health's "Faster Cancer Treatment" programme aims for timely care for patients with cancer, including melanoma. Melanoma care guidelines detail investigation and treatment timeliness standards. This audit assesses compliance with these. Read More

    Digital Anaesthesia and Relevant Digital Anatomy for the Dermatologist.
    J Cutan Med Surg 2017 Sep/Oct;21(5):467-471
    1 The Division of Dermatology, Women's College Hospital, University of Toronto, Toronto, ON, Canada.
    Cutaneous surgery requires a precise understanding of anatomy. This review describes the clinically relevant anatomy of the hand and relates it to the most common methods of digital anaesthesia. Read More

    Isolated limb perfusion for locally advanced angiosarcoma in extremities: A multi-centre study.
    Eur J Cancer 2017 Nov 15;85:114-121. Epub 2017 Sep 15.
    Sarcoma Unit, Department of Surgery, Royal Marsden Hospital, London, United Kingdom; Department of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands. Electronic address:
    Background: Angiosarcomas are rare and aggressive soft-tissue sarcomas. The only potential curative treatment is complete surgical excision. This study reports the outcome of isolated limb perfusion (ILP) with high-dose melphalan and tumour necrosis factor α for locally advanced angiosarcoma. Read More

    Intestinal obstruction due to kaposiform hemangioendothelioma in a 1-month-old infant: A case report.
    Medicine (Baltimore) 2017 Sep;96(37):e6974
    Department of Pediatric Surgery, Seoul National University College of Medicine, Seoul, Korea.
    Rationale: Kaposiform hemangioendothelioma (KHE) is an aggressive vascular tumor, mainly occurring in infants and young children and previously reported cases were mainly cutaneous or visceral form. Intestinal kaposiform hemangioma was first reported in 2012. Intestinal type KHE showed better prognosis if the lesion was limited in the gastrointestinal tract and coagulopathy was not accompanied. Read More

    Giant Chest Wall Arteriovenous Malformation: A Case Report and Literature Review.
    Ann Vasc Surg 2017 Sep 7. Epub 2017 Sep 7.
    Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK. Electronic address:
    Background: We present an interesting case of a 55-year-old male with a large left chest mass after significant cutaneous bleeding. Computed tomography angiogram of the chest revealed arteriovenous malformation with blood supply from sub-branches of the left subclavian artery, left internal mammary artery, and left external carotid artery. Measuring 5. Read More

    A new rabbit model of impaired wound healing in an X-ray-irradiated field.
    PLoS One 2017 8;12(9):e0184534. Epub 2017 Sep 8.
    Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
    Radiation is an important therapy for cancer with many benefits; however, its side effects, such as impaired wound healing, are a major problem. While many attempts have been made to overcome this particular disadvantage, there are few effective treatments for impaired wound healing in an X-ray-irradiated field. One reason for this deficiency is the lack of experimental models, especially animal models. Read More

    Resection of Gastrointestinal Metastases in Stage IV Melanoma: Correlation with Outcomes.
    Am Surg 2016 Nov;82(11):1109-1116
    Department of Cutaneous Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
    The prognosis of patients with gastrointestinal (GI) melanoma metastases is poor. Surgery renders select patients disease free and/or palliates symptoms. We reviewed our single-institution experience of resection with GI melanoma metastases. Read More

    Hyaluronic Acid Accelerates Tendon-to-Bone Healing After Rotator Cuff Repair.
    Am J Sports Med 2017 Sep 1:363546517720199. Epub 2017 Sep 1.
    Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Japan.
    Background: There is growing evidence that the subacromial injection of hyaluronic acid (HA) is effective for pain relief in rotator cuff tears; however, its effect on tendon-to-bone healing remains unknown.

    Purpose: To examine the effect of HA on the chondrogenesis of mesenchymal stem cells (MSCs) in vitro and on tendon-to-bone healing in a rotator cuff repair model.

    Study Design: Controlled laboratory study. Read More

    J Med Liban 2016 Jul-Sep;64(3):164-7
    Background: Soft tissue defects in the foot and ankle region are challenging conditions particularly in diabetic patients. We evaluated the reliability of the sural flap in treating such defects among a diabetic population.

    Material And Methods: This is a continuous retrospective series of 14 patients with type 2 diabetes treated with an ipsilateral sural flap for soft tissue defects around the rear foot (11 cases) and over the malleolar areas (3 cases). Read More

    Anatomical and Clinical Implications of the Deep and Superficial Fat Compartments of the Neck.
    Plast Reconstr Surg 2017 Sep;140(3):405e-414e
    Philadelphia, Pa.; and Dallas, Texas From the Department of Surgery, Division of Plastic Surgery, Temple University; and the Department of Plastic Surgery, University of Texas Southwestern Medical Center.
    Anatomical study has proven vital to the understanding and improvement of rejuvenation techniques of the face and neck. The microscopic septa responsible for individual facial fat compartments are also present in the neck. The authors' anatomical studies of the neck, including supraplatysmal and subplatysmal elements, have influenced their surgical and nonsurgical techniques. Read More

    Osteomyocutaneous fibular flap harvesting: Computer-assisted planning of perforator vessels using Computed Tomographic Angiography scan and cutting guide.
    J Craniomaxillofac Surg 2017 Oct 29;45(10):1681-1686. Epub 2017 Jul 29.
    Maxillofacial Surgery Unit, S. Orsola-Malpighi Hospital, Department of Biomedical and Neuromotor Sciences (Head: Prof. Claudio Marchetti), Alma Mater Studiorum University of Bologna, Via S. Vitale 59, 40125 Bologna, Italy. Electronic address:
    Introduction: Mandibular reconstruction performed after virtual planning has become more common during recent years. The gold standard for extensive mandibular reconstruction is of course a fibular free flap. In designing an osteomyocutaneous fibula flap, poor planning, aberrant anatomy and/or inadequate perforator vessels are the most frequent causes of complications and may force the surgeon to modify the flap design, explore the contralateral leg or harvest an additional microvascular flap. Read More

    Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling.
    Sci Rep 2017 Aug 23;7(1):9181. Epub 2017 Aug 23.
    Bluestone Centre for Clinical Research, New York University College of Dentistry, New York, NY, 10010, USA.
    We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneous sensitivity is pigmentation dependent. Read More

    Expression of IL-23/Th17-related cytokines in basal cell carcinoma and in the response to medical treatments.
    PLoS One 2017 22;12(8):e0183415. Epub 2017 Aug 22.
    Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
    Several immune-related markers have been implicated in basal cell carcinoma (BCC) pathogenesis. The BCC inflammatory infiltrate is dominated by Th2 cytokines, suggesting a specific state of immunosuppression. In contrast, regressing BCC are characterized by a Th1 immune response with IFN-γ promoting a tumor suppressive activity. Read More

    The Pararectus approach provides secure access to the deep circumflex iliac vessel for harvest of a large sized and vascularized segment of the iliac crest.
    Injury 2017 Oct 8;48(10):2169-2173. Epub 2017 Aug 8.
    Department of Orthopaedic and Trauma Surgery, University of Bern, Inselspital, Bern, Switzerland. Electronic address:
    Background: The feasibility of harvesting a vascularized iliac crest utilizing the Pararectus approach was assessed in cadavers and then this new technique was implemented in a clinical case.

    Methods: Bilaterally in five cadavers the branches of both external iliac arteries were injected with colored silicone to assess their position to each other and to harvest a bone graft vascularized by the deep circumflex iliac artery (DCIA) through the Pararectus approach. This technique was implemented in a 68-years-old female patient, initially admitted to a level-I-trauma center after sustaining multiple injuries by falling from great height. Read More

    Blue rubber bleb nevus syndrome: our experience and new endoscopic management.
    Medicine (Baltimore) 2017 Aug;96(33):e7792
    aDepartment of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province bDepartment of Nephrology, Jilin City Central Hospital, Jilin, Jilin Province, China.
    The aim of our study is to enhance the awareness of blue rubber bleb nevus syndrome (BRBNS) through the patients in our hospital and introduced a new measure of endoscopic intervention.A retrospective review of 5 patients, who were diagnosed as BRBNS in our hospital from January 2013 to January 2017, was conducted. Data were collected with regard to demographics, clinical presentation, endoscopic and imaging findings, management, and follow-up data. Read More

    Facial Erosive Pustular Dermatosis After Cosmetic Resurfacing.
    JAMA Dermatol 2017 Oct;153(10):1021-1025
    Department of Dermatology, University of Michigan Medical School, Ann Arbor.
    Importance: Erosive pustular dermatosis (EPD) is a rare condition that typically affects actinically damaged skin of the scalp. Characterized by sterile pustules, erosions, and crusts, EPD is difficult to treat and heals slowly. The exact cause of EPD is unknown, although trauma is an inciting factor. Read More

    Tumor model for surgical simulation to assess a minimally invasive endoscopic approach for midcheek mass removal.
    Surg Oncol 2017 Sep 27;26(3):286-289. Epub 2017 May 27.
    Department of Maxillofacial Surgery, University of Naples "Federico II", Naples, Italy.
    Introduction: The midcheek is considered one of the most important facial area due to its involvement in mimic expression and communication. Pathology of this district is complex due to the variety of soft tissue belonging to the face. We propose a surgical simulation, to assess the feasibility of a new minimally invasive endoscopic approach for midcheek mass removal. Read More

    The surgical anatomy of the vascularized lateral thoracic artery lymph node flap-A cadaver study.
    J Surg Oncol 2017 Aug 7. Epub 2017 Aug 7.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
    Background: One promising surgical treatment of lymphedema is the VLNT. Lymph nodes can be harvested from different locations; inguinal, axillary, and supraclavicular ones are used most often. The aim of our study was to assess the surgical anatomy of the lateral thoracic artery lymph node flap. Read More

    Risk of cutaneous squamous cell carcinoma after treatment of basal cell carcinoma with vismodegib.
    J Am Acad Dermatol 2017 Oct 2;77(4):713-718. Epub 2017 Aug 2.
    Department of Dermatology, University of California San Francisco, San Francisco, California.
    Background: Vismodegib is a first-in-class agent targeting the hedgehog signaling pathway for treatment of patients with locally advanced basal cell carcinoma (BCC) and metastatic BCC. There have been concerns about the development of squamous cell carcinoma (SCC) in patients treated with this drug.

    Objective: We sought to determine whether treatment with vismodegib is associated with an increase in the risk of cutaneous SCC. Read More

    Impairments in Skin Integrity.
    Nurs Clin North Am 2017 Sep;52(3):405-417
    Wound, Ostomy, and Continence Nursing Education Center, Emory University, Nell Hodgson Woodruff School of Nursing, 1520 Clifton Road NE, Atlanta, GA 30322, USA. Electronic address:
    Altered skin integrity increases the chance of infection, impaired mobility, and decreased function and may result in the loss of limb or, sometimes, life. Skin is affected by both intrinsic and extrinsic factors. Intrinsic factors can include altered nutritional status, vascular disease issues, and diabetes. Read More

    Radiological anatomy of the perforators of the gluteal region: The "radiosome" based anatomy.
    Microsurgery 2017 Aug 2. Epub 2017 Aug 2.
    Institute of Human Anatomy, Department of Neuroscience, University of Padova, Italy.
    Background: The superior (SGA) and the inferior gluteal artery (IGA) perforator flaps are widely used in pressure-sore repair and in breast reconstruction. The aim was to exhaustively depict the topographical anatomy of the whole system of perforators in the buttock.

    Methods: Eighty lower-extremity computed tomographic angiography (CTA) of patients (20 males/20 females, mean age 61-years old, range 38-81) were considered. Read More

    [Effects of flow-through descending branch of lateral circumflex femoral artery flap on repairing high-voltage electrical burn wounds of wrist of patients].
    Zhonghua Shao Shang Za Zhi 2017 Jul;33(7):422-425
    Department of Burns, Beijing Jishuitan Hospital, Beijing 100035, China.
    Objective: To investigate the effects of flow-through descending branch of lateral circumflex femoral artery flap on repairing high-voltage electrical burn wounds of wrist of patients. Methods: From January 2014 to June 2016, 5 patients with high-voltage electrical burn of unilateral wrist were hospitalized in our burn ward, with extensive necrosis of skin soft tissue of burn wrist. Five patients were transferred to our burn ward 6 to 12 days post injury after undergoing emergency dermotomy of wrist to reduce tension in other hospitals. Read More

    Anatomy of the medial antebrachial cutaneous nerve and its significance in ulnar nerve surgery: An anatomical study.
    J Plast Reconstr Aesthet Surg 2017 Nov 28;70(11):1582-1588. Epub 2017 Jun 28.
    Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Auenbruggerplatz 29/4, 8036 Graz, Austria.
    Background: During cubital tunnel surgery, the medial antebrachial cutaneous nerve (MACN) may be injured, causing painful scars, neuromas, hypaesthesia or hyperalgesia. As the literature on the anatomy of crossing branches in this area is contradictory, this study aimed to re-examine the anatomy of the MACN in this region.

    Methods: Forty upper limbs were dissected. Read More

    A single-institution assessment of superficial spreading melanoma (SSM) in the pediatric population: Molecular and histopathologic features compared with adult SSM.
    J Am Acad Dermatol 2017 Nov 25;77(5):886-892. Epub 2017 Jul 25.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Robert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois. Electronic address:
    Background: The epidemiology of pediatric melanoma is distinct from that seen in adults. This is more distinguishable when pediatric patients are separated into prepubertal and adolescent groups.

    Objective: In this study, we compared epidemiologic, clinical, histologic, and molecular characteristics of pediatric superficial spreading melanoma (SSM) in prepubertal and adolescent patients to that in adults. Read More

    Loss of cutaneous large and small fibers in naive and l-dopa-treated PD patients.
    Neurology 2017 Aug 26;89(8):776-784. Epub 2017 Jul 26.
    From the Neurology Department (M.N., V.P., A.S., G.C., A.S., F.C., B.L.), Istituti Clinici Scientifici Maugeri SpA Società Benefit, IRCCS Telese Terme, Benevento; Department of Neurosciences, Reproductive Sciences and Odontostomatology (F.M., R.I., L.S.), University Federico II of Naples; and Centre for Neurodegenerative Diseases (M.P., P.B.), Department of Medicine and Surgery, Neuroscience Section, University of Salerno, Italy.
    Objective: To study small and large fiber pathology in drug-naive and l-dopa-treated patients affected by Parkinson disease (PD) in early phases, before the occurrence of neuropathic electrophysiologic abnormalities.

    Methods: We enrolled 85 patients with idiopathic PD (male/female 49/36, age 61.3 ± 9. Read More

    Association of Incident Amelanotic Melanoma With Phenotypic Characteristics, MC1R Status, and Prior Amelanotic Melanoma.
    JAMA Dermatol 2017 Oct;153(10):1026-1031
    Department of Dermatology, University of North Carolina, Chapel Hill.
    Importance: We previously reported that survival is poorer from histopathologically amelanotic than pigmented melanoma because of more advanced stage at diagnosis. Identifying patients at risk of amelanotic melanoma might enable earlier diagnosis and improved survival; however, the phenotypic characteristics and underlying genetics associated with amelanotic melanoma are unknown.

    Objective: To determine whether phenotypic characteristics, carriage of MC1R variants, and history of amelanotic melanoma are associated with histopathologically amelanotic melanoma. Read More

    Identifying an Optimal Adjuvant Radiotherapy Dose for Extremity and Trunk Merkel Cell Carcinoma Following Resection: An Analysis of the National Cancer Database.
    JAMA Dermatol 2017 Oct;153(10):1007-1014
    Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.
    Importance: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine neoplasm with a high risk of recurrence following resection. Despite a rising incidence over the past 3 decades, there is a paucity of prospective data owing to the rarity of this disease.

    Objective: To determine the optimal adjuvant radiation therapy (RT) dose following resection of localized MCC of the extremities or trunk. Read More

    Direct Anthropometry of Repaired Bilateral Complete Cleft Lip: A Long-Term Assessment.
    Plast Reconstr Surg 2017 Aug;140(2):326e-332e
    Boston, Mass. From the Department of Plastic and Oral Surgery, Boston Children's Hospital and Harvard Medical School.
    Background: Repair of bilateral complete cleft lip requires more than following a design in a textbook. The operative strategy should incorporate knowledge of anticipated nasolabial changes with growth.

    Methods: Direct nasolabial anthropometry was recorded in 174 children with bilateral complete cleft lip before and immediately after primary repair. Read More

    Vascularized ulnar periosteal pedicled flap for forearm reconstruction: Anatomical study and a case report.
    Microsurgery 2017 Jul 26. Epub 2017 Jul 26.
    Orthopedic Surgery Department, Pediatric Upper Extremity Surgery and Microsurgery, Hospital Sant Joan de Deu. Passeig Sant Joan de Deu, 2, Esplugues de Llobregat, 08950, Spain.
    Purpose: Through an anatomical review, the aim of this study is to define the ulnar periosteal branches of the posterior interosseous vessels (PIV). In addition, we report the clinical utility of a vascularized ulnar periosteal pedicled flap (VUPPF), supplied by the investigated PIV, in a complex case of radial nonunion.

    Methods: Ten upper limbs latex colored from fresh human cadavers were used. Read More

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