26,893 results match your criteria Anatomy in Cutaneous Surgery


Selective Sensory Axon Reinnervation and TRPV1 Activation.

Mol Neurobiol 2019 Apr 15. Epub 2019 Apr 15.

Division of Neurology, Department of Medicine and the Neuroscience and Mental Health Institute, University of Alberta, 132A-Clinical Sciences Building, 11350 Ave, Edmonton, Alberta, T6G 2G3, Canada.

Current strategies to enhance regeneration of peripheral neurons involve broad activation of sensory, autonomic, and motor axons. Peripheral neuron regeneration is limited in persons with damage or disease of peripheral axons. Here, we provide evidence that subtoxic activation of TRPV1 channels in sensory neurons is associated with activation of growth and subtle changes in skin reinnervation. Read More

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http://link.springer.com/10.1007/s12035-019-1574-6
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http://dx.doi.org/10.1007/s12035-019-1574-6DOI Listing
April 2019
4 Reads

Anatomical variations in the cutaneous innervation on the dorsum of the foot.

Anat Cell Biol 2019 Mar 29;52(1):34-37. Epub 2019 Mar 29.

Department of Anatomy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Generally among the branches of common peroneal nerve, the superficial peroneal nerve provides cutaneous innervation to major part of the dorsum of the foot whereas the deep peroneal nerve innervates the skin over the first interdigital cleft region. The sural and saphenous nerves supplies the smaller lateral and medial margins of the dorsum respectively. The present study has been taken to classify the patterns of innervations of the nerves on the dorsum of the foot in South Indian population. Read More

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http://dx.doi.org/10.5115/acb.2019.52.1.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449594PMC
March 2019
2 Reads

Modified contralateral C7 nerve transfer: the possibility of permitting ulnar nerve recovery is confirmed by 10 cases of autopsy.

Neural Regen Res 2019 Aug;14(8):1449-1454

Department of Hand Surgery, Huashan Hospital, Fudan University; Key Laboratory of Hand Reconstruction, Ministry of Health; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China.

Contralateral C7 nerve transfer surgery is one of the most important surgical techniques for treating total brachial plexus nerve injury. In the traditional contralateral C7 nerve transfer surgery, the whole ulnar nerve on the paralyzed side is harvested for transfer, which completely sacrifices its potential of recovery. In the present, novel study, we report on the anatomical feasibility of a modified contralateral C7 nerve transfer surgery. Read More

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http://dx.doi.org/10.4103/1673-5374.253530DOI Listing
August 2019
1 Read

Expression of mitochondrial dynamics markers during melanoma progression: Comparative study of head and neck cutaneous and mucosal melanomas.

J Oral Pathol Med 2019 Mar 27. Epub 2019 Mar 27.

Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

Background: Head and neck mucosal melanomas (MMs) are rare tumors with adverse outcomes and poorer prognoses than their more common cutaneous counterparts (cutaneous melanomas-CMs). Few studies have compared the expression of mitochondrial dynamic markers in these tumors. This study aimed to assess the correlations of mitochondrial markers with melanoma progression and their potential as predictors of lymph node involvement and distant metastasis. Read More

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http://dx.doi.org/10.1111/jop.12855DOI Listing
March 2019
1 Read

Volar Midcarpal Portals in Wrist Arthroscopy.

J Hand Surg Am 2019 Mar 19. Epub 2019 Mar 19.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN. Electronic address:

Purpose: To describe the placement of volar midcarpal portals using the inside-out technique, and the surrounding anatomical structures at risk.

Methods: Five fresh-frozen cadavers were used. Volar ulnar midcarpal (VUMC) and volar radial midcarpal (VRMC) portals were placed using an inside-out technique. Read More

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http://dx.doi.org/10.1016/j.jhsa.2019.02.006DOI Listing

Cutaneous angiosome of the chimeric SLGA perforator flap: Anatomical study and clinical considerations.

J Plast Reconstr Aesthet Surg 2019 Mar 2. Epub 2019 Mar 2.

CD Laboratory for the Restoration of Extremity Function, Department of Surgery, Medical University of Vienna, Austria; Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Austria. Electronic address:

Background: The superior lateral genicular artery (SLGA) is the basis for a chimeric perforator flap in the lateral knee region, which may include bone, cartilage, fascia, and/or skin. To the best of our knowledge, a detailed description of the corresponding perforator-based skin area is missing in the literature. The aim of this study was to describe the extent and possible variations of the cutaneous angiosome of the SLGA. Read More

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http://dx.doi.org/10.1016/j.bjps.2019.02.016DOI Listing
March 2019
1 Read

Safety and efficacy of halobetasol propionate lotion 0.01% in the treatment of moderate to severe plaque psoriasis: a pooled analysis of 2 phase 3 studies.

Cutis 2018 Feb;102(2):111-116

Bausch Health, Petaluma, California, USA.

Potent topical corticosteroids (TCSs) are the mainstay of psoriasis treatment. Safety concerns have limited use to 2 to 4 weeks. The objective of our study was to investigate the safety and efficacy of once-daily halobetasol propionate (HP) lotion 0. Read More

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February 2018
2 Reads

miRNA-221 promotes cutaneous squamous cell carcinoma progression by targeting PTEN.

Cell Mol Biol Lett 2019 8;24. Epub 2019 Mar 8.

Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, 226001 China.

Background: Cutaneous squamous cell carcinoma (CSCC) is a common type of skin malignancy. MicroRNA-221 (miRNA-221) is a critical non-coding RNA in tumor initiation and progression. However, the molecular mechanisms of miRNA-221 in the development of CSCC remain unknown. Read More

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http://dx.doi.org/10.1186/s11658-018-0131-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407258PMC

Histologic predictors of invasion in partially biopsied lentigo maligna melanoma.

J Am Acad Dermatol 2019 Apr 26;80(4):1150-1152. Epub 2018 Oct 26.

Research Unit EA 4340 Biomarkers in Cancerology and in Hemato-oncology, University of Versailles-Saint-Quentin-en-Yvelines, Université Paris-Saclay, Boulogne-Billancourt, France; Department of Dermatology, Ambroise Paré Hospital, Boulogne-Billancourt, France.

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http://dx.doi.org/10.1016/j.jaad.2018.10.036DOI Listing

Recent dermatology visit is associated with thinner Breslow depth nodular melanomas.

J Am Acad Dermatol 2019 Apr;80(4):1143-1144

Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida; Veterans Affairs Miami Health Care System, Miami, Florida.

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183274
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http://dx.doi.org/10.1016/j.jaad.2018.10.012DOI Listing
April 2019
3 Reads

MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort.

Lancet Child Adolesc Health 2019 May 12;3(5):332-342. Epub 2019 Mar 12.

Molecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy. Electronic address:

Background: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls.

Methods: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. Read More

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http://dx.doi.org/10.1016/S2352-4642(19)30005-7DOI Listing
May 2019
5 Reads

Just a cutaneous (keratotic) horn?

BMJ 2019 Mar 7;364:l595. Epub 2019 Mar 7.

Silverdale Medical Practice, Salford, Manchester, UK.

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http://dx.doi.org/10.1136/bmj.l595DOI Listing

Do Not Forget About the Importance of Loco-Regional Therapy in Melanoma Management.

Semin Radiat Oncol 2019 04;29(2):166-170

Department of Internal Medicine, New York University, New York, NY.

Immunotherapy agents have significantly changed the landscape of melanoma treatment over the past decade. Paradigm shifts in treatment require reanalysis of the treatment algorithms in melanoma. Despite surgical excision, certain high risk patients with desmoplastic melanoma remain at high risk for local recurrence and retrospective data suggests improvement in local control with adjuvant radiation therapy. Read More

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http://dx.doi.org/10.1016/j.semradonc.2018.11.006DOI Listing
April 2019
3 Reads

Single- versus 2-stage reconstruction for chronic post-radiation chest wall ulcer: A 10-year retrospective study of chronic radiation-induced ulcers.

Medicine (Baltimore) 2019 Feb;98(8):e14567

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.

Radiation therapy can have adverse effects on normal tissue and cause chronic ulcers. The purpose of this study was to compare breast cancer patients who underwent single-stage reconstruction with patients who underwent 2-stage reconstruction for chronic radiation-induced necrotic ulcers of the chest wall.This retrospective study comprised of 50 patients with chronic radiation-induced chest wall ulcers who underwent chest wall reconstruction in our hospital between January 2002 and January 2016. Read More

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http://dx.doi.org/10.1097/MD.0000000000014567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408038PMC
February 2019
1 Read

Supra-inguinal injection for fascia iliaca compartment block results in more consistent spread towards the lumbar plexus than an infra-inguinal injection: a volunteer study.

Reg Anesth Pain Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Cardiovascular Sciences, KU Leuven, Katholieke Universiteit Leuven, Leuven, Belgium.

Background And Objectives: Lumbar plexus block has been used to provide postoperative analgesia after lower limb surgery. The fascia iliaca compartment block (FICB) has been proposed as an anterior approach of the lumbar plexus targeting the femoral, obturator and lateral femoral cutaneous nerve. However, both radiological and clinical evidence demonstrated that an infra-inguinal approach to the fascia iliaca compartment does not reliably block the three target nerves. Read More

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http://dx.doi.org/10.1136/rapm-2018-100092DOI Listing
February 2019

A Cadaveric Study of Cutaneous Vascular Anatomy about the Elbow Using Computed Tomography Angiography.

Clin Anat 2019 May 19;32(4):509-514. Epub 2019 Feb 19.

University of Arkansas for Medical Sciences, Little Rock, Arkansas.

The posterior approach is a commonly employed exposure of the elbow that provides excellent visualization and efficacy for various orthopedic procedures, including total elbow arthroplasty (TEA) and fracture care. The posterior approach to the elbow has been associated with an increased rate of wound complications, including infection, skin necrosis, and wound dehiscence. Despite an association between these complications and decreased elbow perfusion, data regarding the intrinsic anatomic etiology for preferential complications in this area has been scarcely reported in the literature. Read More

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http://dx.doi.org/10.1002/ca.23341DOI Listing
May 2019
2 Reads

Efficacy of Wound Coverage Techniques in Extremity Necrotizing Soft Tissue Infections.

Am Surg 2018 Nov;84(11):1790-1795

Little data exist about management of wounds created by debridement in necrotizing soft tissue infections (NSTIs). Multiple wound coverage techniques exist, including complete primary wound closure, split-thickness skin grafting, secondary intention, and flap creation. We hypothesized that all wound coverage techniques would be associated with high rates of successful wound coverage and low crossover rates to other wound coverage techniques. Read More

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November 2018
2 Reads

Loss of CD169 Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma.

Otolaryngol Head Neck Surg 2019 Feb 12:194599819829741. Epub 2019 Feb 12.

1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: The purpose of this study is to assess CD169 expression in metastatic and nearby tumor-free lymph nodes of patients with head and neck squamous cell carcinoma (SCC).

Study Design: Retrospective analysis based on immunohistochemistry.

Setting: Tertiary care center. Read More

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http://dx.doi.org/10.1177/0194599819829741DOI Listing
February 2019

Reptile Embryology and Regeneration.

Methods Mol Biol 2019 ;1920:219-246

Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada.

Reptiles (lizards, snakes, turtles, and crocodilians) are becoming increasingly popular as models for developmental investigations. In this review the leopard gecko, Eublepharis macularius, is presented as a reptilian model for embryonic and tissue regeneration studies. We provide details of husbandry and breeding and discuss aspects of embryonic nutrition, egg anatomy, and sex determination. Read More

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http://dx.doi.org/10.1007/978-1-4939-9009-2_13DOI Listing
January 2019

Misdiagnosed Malignant Tumor on an Ischemic Limb.

Wounds 2019 Feb;31(2):E12-E13

Hospital de Cabueñes, Gijon, Asturias, Spain.

Introduction: Acral lentiginous melanoma (ALM) is a rare variety of melanoma typically located on distal areas of the body. Due to its presentation, it can be confused with a vascular ulcer.

Case Report: The authors present the case of a 68-year-old man who smokes with a history of hypertension, diabetes, and dyslipidemia, who was referred to the vascular clinic with complaints of intermittent claudication and a developing ulcer on his heel. Read More

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February 2019
8 Reads

Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation.

Nat Commun 2019 02 6;10(1):616. Epub 2019 Feb 6.

Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, 20892, MD, USA.

Hematopoietic chimerism after allogeneic bone marrow transplantation may establish a state of donor antigen-specific tolerance. However, current allotransplantation protocols involve genotoxic conditioning which has harmful side-effects and predisposes to infection and cancer. Here we describe a non-genotoxic conditioning protocol for fully MHC-mismatched bone marrow allotransplantation in mice involving transient immunosuppression and selective depletion of recipient hematopoietic stem cells with a CD117-antibody-drug-conjugate (ADC). Read More

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http://dx.doi.org/10.1038/s41467-018-08202-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365540PMC
February 2019
4 Reads

Radiation-induced thoracic necrosis with a pulmonary cutaneous fistula repaired using a free omental flap: a case report.

BMC Surg 2019 Feb 2;19(1):14. Epub 2019 Feb 2.

Department of Plastic Surgery, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama, 359-0042, Japan.

Background: Chest wall necrosis can manifest as a late effect of radiation therapy for breast cancer. Only two cases of fistulas communicating with the respiratory tract as a result of radiation-induced necrosis of the lungs or bronchi have been reported. To the best of our knowledge, we report the first case of a pulmonary cutaneous fistula arising as a late effect of radiation therapy for breast cancer, which was successfully repaired using a free omental graft. Read More

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https://bmcsurg.biomedcentral.com/articles/10.1186/s12893-01
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http://dx.doi.org/10.1186/s12893-019-0479-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360029PMC
February 2019
11 Reads

Anatomical Study of a Chimeric Fascio-Osteomyocutaneous Fibula Flap for Free Microvascular Tissue Transfer.

J Reconstr Microsurg 2019 Jan 31. Epub 2019 Jan 31.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Background:  Functional restoration in reconstructive surgery can require complex and adaptable approaches. In this anatomical study, the combined angiosome of the septofasciomyocutaneous vessels originating from the fibular artery was defined as basis for a chimeric flap of the lateral lower leg.

Methods:  Methylene blue injection into the fibular artery was performed in 10 legs of fresh cadavers for visualization of the angiosome on the skin, fibula, and adjacent muscles as the lateral hemisoleus (HS) muscle. Read More

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http://dx.doi.org/10.1055/s-0039-1677769DOI Listing
January 2019
2 Reads

Cutaneous eruptions associated with haematologic malignancies: the need for a unifying nomenclature.

J Eur Acad Dermatol Venereol 2019 Jan 29. Epub 2019 Jan 29.

Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1111/jdv.15452DOI Listing
January 2019
1 Read

Intratumoral collagen index predicts mortality and survival in canine cutaneous mast cell tumours.

Vet Dermatol 2019 Apr 28;30(2):162-e48. Epub 2019 Jan 28.

Laboratório de Oncologia Comparada e Translacional (LOCT), Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte 255, CEP 13635-900, Pirassununga, Brazil.

Background: Mast cell tumours (MCTs) constitute almost 25% of cutaneous neoplasms in dogs. Their biological behaviour is predicted using histopathological grading which is based on several subjective criteria that are vulnerable to intra- and interobserver variability. To improve the prediction of the biological behaviour, several complementary markers have been studied. Read More

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http://dx.doi.org/10.1111/vde.12726DOI Listing
April 2019
4 Reads

Role of Early Application of Pressure Garments following Burn Injury and Autografting.

Plast Reconstr Surg 2019 02;143(2):310e-321e

Columbus and Cincinnati, Ohio From the Department of Materials Science and Engineering, the Department of Biomedical Engineering, and the Department of Surgery and Division of Critical Care, Trauma and Burns, The Ohio State University; the Research Department, Shriners Hospitals for Children-Cincinnati; and the Department of Surgery, University of Cincinnati College of Medicine.

Background: Pressure garment therapy, used for reduction of postburn scarring, is commonly initiated after complete healing of the wound or autograft. Although some clinicians have suggested that earlier treatment may improve outcomes, the effect of early initiation of therapy has not been studied in a controlled environment.

Methods: Full-thickness burns were created on red Duroc pigs, burn eschar was excised, and the wound bed was grafted with split-thickness autografts. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005270DOI Listing
February 2019
6 Reads

Vulvar malignant melanoma: Pathogenesis, clinical behaviour and management: Review of the literature.

Cancer Treat Rev 2019 Feb 24;73:91-103. Epub 2018 Dec 24.

Department of Gynaecology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Vulvar malignant melanoma (VMM) is a rare disease, accounting for 5% of all vulvar malignancies and is characterized by low survival and high recurrence rates. It is considered as a distinct entity of mucosal melanoma. Prognostic factors are higher age, advanced Breslow thickness, and lymph node involvement whilst central localization and ulceration status are still under debate. Read More

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http://dx.doi.org/10.1016/j.ctrv.2018.12.005DOI Listing
February 2019
10 Reads

Free bipaddled anterolateral thigh flap for simultaneous reconstruction of large larynx and prelaryngeal skin defects after resection of the local recurrent laryngeal cancer invading the cricoid cartilage and prelaryngeal skin: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14199

Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Rationale: After total or near-total laryngectomy and resection of prelaryngeal skin, laryngeal defects and prelaryngeal skin defects often remain a great challenge for head and neck surgeons when considering simultaneous reconstruction of. In this case report, a free bipaddled anterolateral thigh (ALT) was used for such defects reconstruction.

Patient Concerns: For this 50-year-old male patient whose recurrent tumor invaded the cricoid cartilage and the prelaryngeal skin, supracricoid partial laryngectomy with a cricohyoidepiglottopexy would no longer be an option. Read More

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http://dx.doi.org/10.1097/MD.0000000000014199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358393PMC
January 2019
2 Reads
5.723 Impact Factor

[Clinical effects of perforating branch flaps of medial vastus muscle in repairing secondary wounds in donor sites of free anterolateral femoral perforator flaps].

Zhonghua Shao Shang Za Zhi 2019 Jan;35(1):65-68

Department of Orthopaedics, Tianjin Hospital, Ningqiang County, Hanzhong City, Hanzhong 724400, China.

To investigate the clinical effects of perforating branch flaps of medial vastus muscle in repairing secondary wounds in donor sites of free anterolateral femoral perforator flaps. From August 2014 to December 2016, 12 patients (8 males and 4 females, aged 35-72 years) with skin and soft tissue defects of extremities associated with tendon and bone exposure were treated in Hanzhong Central Hospital. The sizes of the primary wounds after debridement were 10 cm×8 cm-22 cm×14 cm, and the wounds were repaired with 12 cm×10 cm-24 cm×16 cm free anterolateral femoral perforator flaps. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.01.012DOI Listing
January 2019

Clinical, genetic and experimental studies of the Brooke-Spiegler (CYLD) skin tumor syndrome.

J Plast Surg Hand Surg 2019 Apr 24;53(2):71-75. Epub 2019 Jan 24.

a Sahlgrenska Cancer Center, Department of Pathology , University of Gothenburg , Gothenburg , Sweden.

Brooke-Spiegler syndrome (BSS; a.k.a. Read More

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https://www.tandfonline.com/doi/full/10.1080/2000656X.2018.1
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http://dx.doi.org/10.1080/2000656X.2018.1547736DOI Listing
April 2019
9 Reads

The pecs anesthetic blockade: A correlation between magnetic resonance imaging, ultrasound imaging, reconstructed cross-sectional anatomy and cross-sectional histology.

Clin Anat 2019 Apr 5;32(3):421-429. Epub 2019 Feb 5.

Department of Functional Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands.

The interfascial thoracic wall blockades Pecs I and Pecs II are increasingly applied in breast and axillary surgery. Despite the clear anatomical demarcations depicted at their introduction, the clinical outcome is more variable than would be expected based upon the described anatomy. In order to elucidate factors that explain this variability, we evaluated the spread of each injection-medial Pecs I, lateral Pecs I, the deep injection of the Pecs II-separately. Read More

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http://dx.doi.org/10.1002/ca.23333DOI Listing
April 2019
5 Reads

Droplet digital PCR for detection of mutation in formalin-fixed, paraffin-embedded melanoma tissues: a comparison with Cobas 4800, Sanger sequencing, and allele-specific PCR.

Am J Transl Res 2018 15;10(11):3773-3781. Epub 2018 Nov 15.

Division of Oncology, Slovakia JFM CU, Biomedical Center Martin JFM CU, Jessenius Faculty of Medicine in Martin (JFM CU), Commenius University in Bratislava Mala Hora 4C, 036 01 Martin.

Cutaneous melanoma has the worst prognosis of all skin cancers. Although emerging targeted therapies, such as B-Raf kinase inhibitor vemurafenib, improve prognosis they require an accurate and sensitive means of detecting the pathogenic mutation. We compared the sensitivity of four detection methods in formalin-fixed, paraffin-embedded melanoma biopsies from 87 consecutive melanoma patients with Breslow stage I-V disease (staging based on the depth of tumor of invasion). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291720PMC
November 2018
4 Reads

Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas.

Oncotarget 2018 Dec 18;9(99):37291-37304. Epub 2018 Dec 18.

Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Read More

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http://dx.doi.org/10.18632/oncotarget.26458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324666PMC
December 2018
2 Reads

Reconstructive limb-salvage surgery after lower extremity soft tissue sarcoma resection: A 20-year experience.

J Surg Oncol 2019 May 15;119(6):708-716. Epub 2019 Jan 15.

Department of Plastic and Reconstructive Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Reconstructive surgery is often required following lower extremity soft tissue sarcoma resection. The relationship between the method of plastic surgery reconstruction and postoperative wound healing or functional oncologic outcomes in this patient population is poorly understood.

Methods: We performed a retrospective review on all adult patients that underwent soft tissue reconstruction following resection of lower extremity soft tissue sarcomas between 1996 and 2016 at our institution. Read More

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http://dx.doi.org/10.1002/jso.25358DOI Listing
May 2019
1 Read

Melanoma types by in vivo reflectance confocal microscopy correlated with protein and molecular genetic alterations: A pilot study.

Exp Dermatol 2019 Mar 11;28(3):254-260. Epub 2019 Feb 11.

Department of Surgery, Medicine, Dentistry and Morphological Sciences with interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Cutaneous melanoma (CM) is one of the most prevalent skin cancers, which lacks both a prognostic marker and a specific and lasting treatment, due to the complexity of the disease and heterogeneity of patients. Reflectance confocal microscopy (RCM) in vivo analysis is a versatile approach offering immediate morphological information, enabling the identification of four primary cutaneous RCM CM types. Whether RCM CM types are associated with a specific protein and molecular genetic profiles at the tissue level remains unclear. Read More

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http://dx.doi.org/10.1111/exd.13877DOI Listing
March 2019
12 Reads
3.762 Impact Factor

Ultrasound-guided selective block of the medial brachial cutaneous and the intercostobrachial nerves for proximal arteriovenous fistula surgery.

Reg Anesth Pain Med 2019 Jan 11. Epub 2019 Jan 11.

Department of Anesthesiology, Hospital Clínic, Barcelona, Spain

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http://dx.doi.org/10.1136/rapm-2018-100298DOI Listing
January 2019
2 Reads

Pathology of Birt-Hogg-Dubé syndrome: A special reference of pulmonary manifestations in a Japanese population with a comprehensive analysis and review.

Pathol Int 2019 Jan 11;69(1):1-12. Epub 2019 Jan 11.

Department of Pathology, Yokosuka Kyosai Hospital, Yokosuka, Japan.

Birt-Hogg-Dubé (BHD) syndrome is a rare genetic disorder characterized by cutaneous fibrofolliculomas, pulmonary cysts and renal cell carcinomas. Affected individuals inherit germline mutations in the folliculin gene (FLCN). Approximately 150 pathogenic FLCN variants have been identified worldwide. Read More

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http://dx.doi.org/10.1111/pin.12752DOI Listing
January 2019

Invalid freeze-dried platelet gel promotes wound healing.

Saudi Pharm J 2019 Jan 20;27(1):33-40. Epub 2018 Jul 20.

Siriraj Center of Research Excellence for Molecular Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Wound healing is the curative process of tissue injury, composed of three phases: the inflammatory phase, proliferative phase, followed by the maturation cum remodeling phase. Various treatment options were previously depicted for wound healing, however a treatment that accelerates these phases would be highly valuable. Platelet aggregation at the bleeding vessels and release of various growth factors are the most promising factors that stimulates the wound healing progress. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323128PMC
January 2019
2 Reads

Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars.

J Immunol Res 2018 28;2018:5196023. Epub 2018 Nov 28.

"Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania.

Wound healing is a complex biologic process evolving in three phases: inflammation, proliferation, and tissue remodeling controlled by numerous growth factors and cytokines. Oral mucosa wounds heal with significantly less important scars with less numerous macrophages and mast cells and more numerous myofibroblasts than cutaneous counterparts. We analyzed 32 cutaneous and 32 oral mucosa scars for TGFbeta1, TGFbeta2, TGFbeta3, TNFalpha, PDGF BB and FGF1 expression in mesenchymal cells, endothelial cells, macrophages, and multinucleated giant cells. Read More

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http://dx.doi.org/10.1155/2018/5196023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304192PMC
April 2019
1 Read

Understanding Anatomy of the Petrous Pyramid-A New Compartmental Approach.

World Neurosurg 2019 Jan 5. Epub 2019 Jan 5.

Department of Anatomy, University of Lyon 1, Lyon, France; Skull Base Multi-disciplinary Unit, Department of Neurosurgery B, Neurological Hospital Pierre Wertheimer, Hospices Civils de Lyon, Lyon Cedex, France.

Background: Learning surgical anatomy of the petrous pyramid can be a challenge, especially in the beginning of the training process. Providing an easier, holistic approach can be of help to everyone with interest in learning and teaching skull base anatomy. We present the complex organization of petrous pyramid anatomy using a new compartmental approach that is simple to understand and remember. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183279
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http://dx.doi.org/10.1016/j.wneu.2018.11.234DOI Listing
January 2019
10 Reads

Three-Dimensional Vascular Anatomical Study of the Tensor Fasciae Latae Muscle and Perforators.

J Reconstr Microsurg 2019 Jan 7. Epub 2019 Jan 7.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Dalhousie University, Halifax, Canada.

Background:  To harvest any flap on the lateral circumflex femoral artery (LCFA) including tensor fasciae latae (TFL) muscle, a precise description of the vascular anatomy is required. There have been conflicting reports of the vascular supply of TFL and its overlying skin. The objective of this study was to evaluate the anatomy of the TFL muscle according to the location, origin, type, caliber, and length of vessels that supply the muscle. Read More

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http://dx.doi.org/10.1055/s-0038-1677010DOI Listing
January 2019
11 Reads

A Giant Cutaneous Horn on the Cheek.

Facial Plast Surg 2018 Dec 28;34(6):663-664. Epub 2018 Dec 28.

Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

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http://dx.doi.org/10.1055/s-0038-1675635DOI Listing
December 2018
2 Reads

Face and Neck Lift-Postoperative Care.

Facial Plast Surg 2018 Dec 28;34(6):561-569. Epub 2018 Dec 28.

Department of ENT, North Cumbria University Hospitals NHS Trust, Whitehaven, Cumbria, United Kingdom.

Primary aim of the article is a discussion of the postoperative care after face and neck lift. A brief history of face and neck lift along with different techniques are described. Importance of preoperative assessment is stressed. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676380
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http://dx.doi.org/10.1055/s-0038-1676380DOI Listing
December 2018
1 Read

TNF-alpha and metalloproteases as key players in melanoma cells aggressiveness.

J Exp Clin Cancer Res 2018 Dec 28;37(1):326. Epub 2018 Dec 28.

Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, ISS, viale Regina Elena 299, 00161, Rome, Italy.

Background: Melanoma aggressiveness determines its growth and metastatic potential. This study aimed at identifying new molecular pathways controlling melanoma cell malignancy.

Methods: Ten metastatic melanoma cell lines were characterized by their proliferation, migration and invasion capabilities. Read More

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http://dx.doi.org/10.1186/s13046-018-0982-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309098PMC
December 2018
1 Read

A New Approach to an Old Flap: A Technique to Augment Venous Drainage from the Paramedian Forehead Flap.

Plast Reconstr Surg 2019 01;143(1):269-271

Sheffield and London, United Kingdom From the Department of Plastic Surgery, Sheffield Teaching Hospitals NHS Foundation Trust; the Departments of Radiology and Plastic Surgery, Guy's and St Thomas' NHS Foundation Trust; and the Department of Anatomy, King's College London.

The paramedian forehead flap is commonly used in nasal reconstruction, and survival of the distal part of the flap is usually essential for a good cosmetic outcome. Venous congestion leading to tissue necrosis is a recognized complication with this flap. The standard paramedian forehead flap is designed with a number of aims. Read More

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http://Insights.ovid.com/crossref?an=00006534-201901000-0005
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http://dx.doi.org/10.1097/PRS.0000000000005121DOI Listing
January 2019
7 Reads

Small Bowel Pyogenic Granuloma With Cytomegalovirus Infection in a Patient With Crohn's Disease (Report of a Case and Review of the Literature).

In Vivo 2019 Jan-Feb;33(1):251-254

Department of Pathology, Immunology and Laboratory of Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Pyogenic granuloma (PG) represents a lobular capillary proliferation commonly seen in the skin or oral mucosa. They are rarely reported in the gastrointestinal tract. The mechanism underlying PG pathogenesis is not well understood. Read More

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http://dx.doi.org/10.21873/invivo.11468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364075PMC
April 2019
14 Reads
1.148 Impact Factor

[Clinical application of computed tomography angiography and three-dimensional reconstruction in repairing high-voltage electrical burn wounds in necks, shoulders, axillas, and upper arms with tissue flaps].

Zhonghua Shao Shang Za Zhi 2018 Dec;34(12):874-880

Department of Burns and Plastic Surgery, General Hospital of Ningxia Medical University, Yinchuan 750004, China.

To explore the application value of computed tomography angiography (CTA) and three-dimensional reconstruction in repairing high-voltage electrical burn wounds in necks, shoulders, axillas, and upper arms with tissue flaps. From December 2014 to December 2018, 12 patients with high-voltage electrical burns in necks, shoulders, axillas, and upper arms were hospitalized. The size of wounds ranged from 13 cm×10 cm to 32 cm×15 cm after complete debridement. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2018.12.011DOI Listing
December 2018

Primary cutaneous 'ulcerative' tuberculosis of the scrotum: a rare occurrence.

BMJ Case Rep 2018 Dec 19;11(1). Epub 2018 Dec 19.

General Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Tuberculosis (TB) is a global disease and if not adequately treated can lead to morbidity and mortality. Though genitourinary TB is common and only next to pulmonary TB, cutaneous 'ulcerative' tuberculosis of the scrotum is not reported so far in the literature. We present a 32-year-old man with a non-healing scrotal ulcer and underwent excision. Read More

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http://dx.doi.org/10.1136/bcr-2018-227177DOI Listing
December 2018
7 Reads

Epidermoid Cyst Arising on the Body of the Tongue: Case Report and Literature Review.

J Nippon Med Sch 2018 ;85(6):343-346

Department of Cutaneous and Mucosal Pathophysiology, Graduate School of Medicine, Nippon Medical School.

Background: Epidermoid cysts of the body of the tongue are rare. Only 12 cases of such lesions have been reported in the English literature.

Case: A 14-year-old boy had a 7×5-mm-sized cystic lesion with a yellowish-white surface on the ventral aspect of his tongue. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2018_85-56DOI Listing
February 2019
2 Reads