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    Atorvastatin attenuates testosterone induced benign prostatic hyperplasia in rats: role of peroxisome proliferator activated receptor-γ and cyclo-oxygenase-2.
    Fundam Clin Pharmacol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
    Diabetes and obesity have been reported to alter sex steroid hormone metabolism. In this study, an attempt was made to investigate the protective effect of atorvastatin (ATR) in combination with celecoxib (CEL) or pioglitazone (PIO) on testosterone-induced BPH in rats. Male Wistar rats (200-250 g) were randomly divided into 9 groups (n=8) and orally treated as follows for 28 consecutive days; Group 1: vehicle (10 ml/kg), group 2: vehicle (10 ml/kg), groups 3 - 5: ATR (0. Read More

    Tumor Metabolism in the Microenvironment of Nodal Metastasis in Oral Squamous Cell Carcinoma.
    Otolaryngol Head Neck Surg 2017 Jun 1:194599817709224. Epub 2017 Jun 1.
    4 Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
    Objective In many cancers, including head and neck squamous cell carcinoma (HNSCC), different regions within a tumor have different metabolic phenotypes. Transfer of metabolites between compartments promotes tumor growth and aggressive behavior. Metabolic compartmentalization in HNSCC nodal metastases has not been studied, nor has its impact on extracapsular extension or clinical outcomes been determined. Read More

    Transverse Cervical Artery Perforator Flap: Standardized Surgical Technique and Multiple Reconstructive Opportunity in Head and Neck Surgery.
    Ann Plast Surg 2017 Jun 9. Epub 2017 Jun 9.
    From the *Department of Clinical Sciences and Community Health, San Giuseppe Hospital-Multimedica Group, Università degli Studi di Milano, Milan, Italy; and †Department of Human Anatomy and Histology, Universidad Miguel Hernández de Alicante, Spain.
    The main purpose of head and neck reconstructive surgery is to provide anatomic restoration of the demolited region and to provide preservation and recovery of function. The anatomical investigations conducted over the years has enabled a detailed knowledge of human body vascularization, giving the opportunity to design and harvest more and more versatile and refined flaps, with increasingly satisfactory results. Even if in the last 2 decades free flaps have been considered a reconstructive criterion standard, they still determine a great physical impact for the patient and require a certain surgical experience. Read More

    Aberrant Cutaneous Nerve Loops in the Axilla.
    Acta Medica (Hradec Kralove) 2017 ;60(1):51-54
    Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
    During routine dissection classes, conducted for first year undergraduate medical students, we encountered a rare anatomical variation in relation to the intercostobrachial nerve (ICBN). The ICBN represents the lateral undivided cutaneous branch of second intercostal nerve. In this case, the ICBN formed nerve loops with branches of the lateral cutaneous branch of the third intercostal nerve. Read More

    Using a Thermal Imaging Camera to Locate Perforators on the Lower Limb.
    Arch Plast Surg 2017 May 22;44(3):243-247. Epub 2017 May 22.
    School of Medicine, University of Queensland, Brisbane, New Zealand.
    Reconstruction of the lower limb presents a complex problem after skin cancer surgery, as proximity of skin and bone present vascular and technical challenges. Studies on vascular anatomy have confirmed that the vascular plane on the lower limb lies deep to the deep fascia. Yet, many flaps are routinely raised superficial to this plane and therefore flap failure rates in the lower limb are high. Read More

    Anatomy of the cutaneous lymphatic system of the trunk: a clinico-anatomical study of 90 cutaneous melanomas.
    Surg Radiol Anat 2017 May 29. Epub 2017 May 29.
    Rouen University, Rouen Cedex 1, France.
    Purpose: The cutaneous lymphatic system of the trunk is a complex network, the anatomical knowledge of which remains unclear. The lymphatic system plays a major role in the dissemination of lymphophilic cancers like melanomas. The aim of this study was to improve our knowledge, optimize the care of patients with cutaneous tumors of the trunk, and to use our clinical experience of the topography of pathologic lymph nodes related to cutaneous melanomas and depicted by lymphoscintigraphy. Read More

    Snail mucus - glandular origin and composition in Helix pomatia.
    Zoology (Jena) 2017 Jun 5;122:126-138. Epub 2017 May 5.
    Core Facility Cell Imaging and Ultrastructure Research, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, A-1200 Vienna, Austria. Electronic address:
    Apart from their well-known culinary use, gastropod species such as Helix, which have a hydrogel-like mucus, are increasingly being exploited for cosmetic, bioengineering and medical applications. However, not only are the origin and composition of these "sticky" secretions far from being fully characterized, the number and morphology of the mucus glands involved is also uncertain. This study aims to characterize in detail the cutaneous glands of the Helix pomatia foot on morphological, histochemical and immunohistochemical levels. Read More

    Platelet-released growth factors induce psoriasin in keratinocytes: Implications for the cutaneous barrier.
    Ann Anat 2017 May 25;213:25-32. Epub 2017 May 25.
    Department of Dermatology, University Hospital of Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 7, 24105 Kiel, Germany.
    Millions of patients around the world suffer minor or major extremity amputation due to progressive wound healing complications of chronic or infected wounds, the therapy of which remains a challenge. One emerging therapeutic option for the treatment of these complicated wounds is the local application of an autologous thrombocytes concentrate lysate (e.g. Read More

    Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma.
    Oncotarget 2017 May 2. Epub 2017 May 2.
    Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.
    Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Inflammation is a typical feature in cSCC progression. Analysis of the expression of inflammasome components in cSCC cell lines and normal human epidermal keratinocytes revealed upregulation of the expression of AIM2 mRNA and protein in cSCC cells. Read More

    Origin, Branching, and Communications of the Intercostobrachial Nerve: a Meta-Analysis with Implications for Mastectomy and Axillary Lymph Node Dissection in Breast Cancer.
    Cureus 2017 Mar 17;9(3):e1101. Epub 2017 Mar 17.
    Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
    The intercostobrachial nerve (ICBN), which usually originates from the lateral cutaneous branch of the second intercostal nerve, innervates areas of the axilla, lateral chest, and medial arm. It is at risk for injury during operative procedures that are often used in the management of breast cancer and such injury has been associated with postoperative sensory loss and neuropathic pain, decreasing the quality of life. PubMed, Excerpta Medica Database (EMBASE), ScienceDirect, Google Scholar, China National Knowledge Infrastructure (CNKI), Scientific Electronic Library Online (SciELO), Biosciences Information Service (BIOSIS), and Web of Science were searched comprehensively. Read More

    Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.
    PLoS One 2017 19;12(4):e0175755. Epub 2017 Apr 19.
    The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Australia.
    Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Read More

    Management of the extensive thoracic defects after deep sternal wound infection with the rectus abdominis myocutaneous flap: A retrospective case series.
    Medicine (Baltimore) 2017 Apr;96(16):e6391
    aDepartment of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University bXi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
    Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wound management, especially when 1 or 2 internal mammary arteries were absent. Read More

    Droplet digital PCR (ddPCR) vs quantitative real-time PCR (qPCR) approach for detection and quantification of Merkel cell polyomavirus (MCPyV) DNA in formalin fixed paraffin embedded (FFPE) cutaneous biopsies.
    J Virol Methods 2017 Aug 14;246:15-20. Epub 2017 Apr 14.
    Department of Experimental and Clinical Medicine, University of Florence, Italy. Electronic address:
    Background: Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma and high viral load in the skin was proposed as a risk factor for the occurrence of this tumour. MCPyV DNA was detected, with lower frequency, in different skin cancers but since the viral load was usually low, the real prevalence of viral DNA could be underestimated.

    Objective: To evaluate the performance of two assays (qPCR and ddPCR) for MCPyV detection and quantification in formalin fixed paraffin embedded (FFPE) tissue samples. Read More

    Malignant Melanoma in African-Americans: A Population-Based Clinical Outcomes Study Involving 1106 African-American Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1988-2011).
    Medicine (Baltimore) 2017 Apr;96(15):e6258
    aDepartment of Surgery, Saint Barnabas Medical Center, Livingston, NJ bSaint George's University School of Medicine, Grenada, West Indies cDepartment of Surgery, New Jersey Medical School, Rutgers University, Newark, NJ dDepartment of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ.
    Malignant melanoma accounts for 75% of all skin cancer deaths and is potentially curable if identified early. Although melanoma is rare in African-Americans (AA), it is associated with a worse prognosis than in Caucasians. This study examines the demographic, pathologic, and clinical factors impacting AA melanoma outcomes. Read More

    FIBRIN GEL AS A SCAFFOLD FOR SKIN SUBSTITUTE--PRODUCTION AND CLINICAL EXPERIENCE.
    • Authors:
    Acta Clin Croat 2016 Jun;55(2):279-89
    The purpose of this study was to create a fibrin-based human skin substitute in vitro with epidermal and dermal component and to assess its healing potential in deep partial and full thickness burns. Fibrin scaff olds were prepared from commercial fibrin glue kits. Human fibroblasts were cultured in fibrin gel. Read More

    Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration.
    Aesthet Surg J 2017 May;37(suppl_1):S20-S31
    Dr Nestor is a Voluntary Associate Professor, Department of Dermatology and Cutaneous Surgery, Department of Surgery, Division of Plastic Surgery, University of Miami Leonard Miller School of Medicine, Miami, FL. Dr Ablon is an Associate Clinical Professor of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA. Dr Pickett is Director and Founder of Toxin Science Limited, Wrexham, UK; and an Adjunct Professor at the Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA.
    Time to onset of response and duration of response are key measures of botulinum toxin efficacy that have a considerable influence on patient satisfaction with aesthetic treatment. However, there is no overall accepted definition of efficacy for aesthetic uses of botulinumtoxinA (BoNT-A). Mechanical methods of assessment do not lend themselves to clinical practice and clinicians rely instead on assessment scales such as the Frontalis Activity Measurement Standard, Frontalis Rating Scale, Wrinkle Severity Scale, and Subject Global Assessment Scale, but not all of these have been fully validated. Read More

    Sustained attractiveness and natural youthful appearance by upper lip rejuvenation : Minimally invasive procedures to combat facial aging.
    Wien Med Wochenschr 2017 Apr 5. Epub 2017 Apr 5.
    Clinica Goldman, Porto Alegre/RS, Brazil.
    Facial aging is a complex process individualized by interaction with exogenous and endogenous factors. The upper lip is one of the facial components by which facial attractiveness is defined. Upper lip aging is significantly influenced by maxillary bone and teeth. Read More

    A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities.
    Int J Mol Sci 2017 Apr 3;18(4). Epub 2017 Apr 3.
    State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China.
    The seeds of Strychnosnux-vomica L., as a traditional Chinese medicine, have good anti-inflammatory and analgesic activities. However, it usually leads to gastrointestinal irritation and systemic toxicity via oral administration. Read More

    Three-Dimensional (3D) Columellar Strut Graft in Rhinoplasty.
    Aesthet Surg J 2017 Apr;37(4):398-406
    Dr Topkara is an Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, Pamukkale University Hospital, Denizli, Turkey.
    Background: Nasal tip surgery is the most important and most difficult step of an aesthetic rhinoplasty operation. Various suture and grafting techniques have been described for adequate tip rotation and projection in nasal tip surgery.

    Objectives: The author describes his technique of "three-dimensional (3D) columellar strut graft" in nasal tip surgery. Read More

    Relevant Insertion Site Anatomy of the Conventus Distal Radius System.
    Hand (N Y) 2017 Mar 1:1558944717701239. Epub 2017 Mar 1.
    1 Valley Orthopedic Surgery Residency, Modesto, CA, USA.
    Background: The Conventus Distal Radius System (DRS) is an intramedullary fixation scaffold inserted into the lateral aspect of the distal radius. The purpose of this study was to identify insertion site anatomy to illustrate risks associated with the minimally invasive nature of radial-sided implant application.

    Methods: Ten cadavers were utilized. Read More

    General Guidelines for Quality Assurance of Immunohistochemistry in a Mohs Lab.
    Dermatol Surg 2017 Apr;43(4):507-511
    *Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia;†Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
    Background: The adoption of recently created protocols introduces Mohs laboratories to the principles of immunohistochemistry (IHC) performance validation and clinical laboratory regulations that are unique to these evolving technologies.

    Objective: To review Food and Drug Administration (FDA) IHC reagent classifications, IHC validation protocols, and quality assurance (QA) procedures and documentation needed in conjunction with IHC test guidelines.

    Methods: A focused review of IHC reagent classifications and guidelines in clinical testing laboratories was conducted using PubMed and FDA source documents. Read More

    The Relationship of Superficial Cutaneous Nerves and Interperforator Connections in the Leg: A Cadaveric Anatomical Study.
    Plast Reconstr Surg 2017 Apr;139(4):994e-1002e
    Melbourne, Victoria, Australia From the Jack Brockhoff Reconstructive Plastic Surgery Research Unit (Taylor Lab), Department of Anatomy and Neurosciences, University of Melbourne.
    Background: The lower limb is a source of many flaps both for closure of local defects and for free transfer. Fasciocutaneous flap techniques have been progressively refined, although the vascular basis for their success needs clarification.

    Methods: Archival studies of 48 lower limbs were reviewed and combined with 20 studies of lower limbs from fresh cadavers, making a total of 68 investigations. Read More

    Reporting of mitotic rate in cutaneous melanoma: A study using the national cancer data base.
    J Surg Oncol 2017 Mar;115(3):281-286
    Department of Surgery, Carolinas Medical Center, Levine Cancer Institute, Charlotte, North Carolina.
    Background: The seventh edition of the American Joint Commission on Cancer staging manual (AJCC7, published 2009), updated thin cutaneous melanoma staging protocols with the incorporation of mitotic rate (MR). In these patients, higher MR is associated with decreased survival. This study utilizes the National Cancer Data Base (NCDB) to evaluate MR reporting since AJCC7. Read More

    The role of imaging in the management of patients with nonmelanoma skin cancer: When is imaging necessary?
    J Am Acad Dermatol 2017 Apr;76(4):591-607
    Department of Dermatology, MD Anderson Cancer Center, Houston, Texas.
    When treating aggressive skin cancers, pre- and postoperative imaging provides important information for treatment planning and multidisciplinary cooperation of care. It is important for dermatologists to recognize the clinical scenarios where imaging is indicated in the management of skin cancer. We here address the most common indications for imaging in cutaneous oncology and how to best utilize the modalities available. Read More

    Mucosal melanoma of the head and neck.
    Crit Rev Oncol Hematol 2017 Apr 13;112:136-152. Epub 2017 Feb 13.
    Department Melanoma, Soft Tissues, Musculoskeletal and Head & Neck, Italian National Cancer Institute - IRCCS Pascale Foundation, Naples, Italy.
    Mucosal melanoma of the head and neck is a very rare and aggressive malignancy with a very poor prognosis. The nasal cavity, paranasal sinuses, and oral cavity are the most common locations. One-, 3- and 5-year survival rates between 2000 and 2007 were 63%, 30% and 20%, respectively. Read More

    Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma.
    Am J Pathol 2017 May 17;187(5):1186-1197. Epub 2017 Mar 17.
    Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland. Electronic address:
    Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8) and normal human epidermal keratinocytes (n = 11) with real-time quantitative PCR and Western blotting revealed up-regulation of C3 and CFB expression in cSCC cells. Read More

    Medial Canthoplasty Combined with Conjunctivodacryocystorhinostomy for the Treatment of Delayed Medial Telecanthal Deformity.
    Chin Med J (Engl) 2017 Mar;130(6):698-702
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing 100730, China.
    Background: Rupture of the medial canthal ligament can be caused by many events. It remains a challenge to rebuild the drainage system and restore the function. The aim of this study was to evaluate the clinical efficacy of medial canthoplasty combined with conjunctivodacryocystorhinostomy (CDCR) in patients with medial telecanthal deformities and lacrimal drainage system damage. Read More

    Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis.
    Int J Mol Sci 2017 Mar 10;18(3). Epub 2017 Mar 10.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo 113-8603, Japan.
    Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. Read More

    Retrospective study of rare cutaneous malignant adnexal tumors of the head and neck in a tertiary care cancer hospital: a case series.
    J Med Case Rep 2017 Mar 12;11(1):67. Epub 2017 Mar 12.
    Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, 7-A, Block-R3, Johar Town, Lahore, Pakistan.
    Background: Adnexal tumors of the skin are a large and diverse group of benign and malignant neoplasms, which exhibit morphological differentiation toward one of the different types of adnexal epithelium present in normal skin and they pose a diagnostic challenge. The purpose of this study is to share our experience with these rare but aggressive tumors at a tertiary care cancer hospital in a developing country. A retrospective review of 11 patients diagnosed with rare adnexal tumors and their variants from January 2005 to December 2014, treated either surgically or non-surgically, was performed to describe the clinicopathological characteristics and outcome of the disease. Read More

    Phase 1b study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced melanoma (KEYNOTE-041).
    Cancer Chemother Pharmacol 2017 Apr 11;79(4):651-660. Epub 2017 Mar 11.
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Purpose: This phase I b study evaluated the safety and anti-tumor activity of pembrolizumab in Japanese patients with advanced melanoma.

    Methods: Pembrolizumab (2 mg/kg) was given every 3 weeks (Q3W) for up to 2 years or until confirmed progression or unacceptable toxicity. The tumor response was assessed as per the Response Evaluation Criteria in Solid Tumors version 1. Read More

    A 92-year-old man with primary cutaneous diffuse large B-cell non-Hodgkin's lymphoma manifesting as a giant scalp mass: A case report.
    Medicine (Baltimore) 2017 Mar;96(10):e6270
    Department of Neurosurgery, XinHua Hospital affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China.
    Rationale: Primary cutaneous non-Hodgkin's lymphoma (NHL) is an uncommon entity, representing 10% of all extranodal NHLs. Among all cutaneous sites, the scalp is a rare site of representation.

    Patient Concerns: A 92-year-old Chinese man visited our hospital with a multiple-nodular huge scalp mass on the right parieto-occipital regions. Read More

    Cutaneous Radiation-associated Breast Angiosarcoma: Radicality of Surgery Impacts Survival.
    Ann Surg 2017 Apr;265(4):814-820
    *Division of Surgical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA†Division of Plastic Surgery, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA‡Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA.
    Objective: Cutaneous radiation therapy (RT)-associated breast angiosarcoma (AS) is a rare consequence of breast RT associated with poor outcomes. Previous small case series have documented high recurrence rates and poor survival. We reviewed our experience and focused on the impact of conservative versus radical resections. Read More

    Bimatoprost for the treatment of eyelash, eyebrow and scalp alopecia.
    Expert Opin Investig Drugs 2017 Apr 16;26(4):515-522. Epub 2017 Mar 16.
    b Department of Dermatology and Cutaneous Surgery , University of Miami, Miller School of Medicine , Miami , FL , USA.
    Introduction: Alopecia is a common condition observed among people of all ages. It is a disorder that can involve only the scalp as observed in androgenetic alopecia or scalp and body as in alopecia areata or patients under chemotherapy treatment. There are several treatment options with different safety and efficacy outcomes. Read More

    Expression of Programmed Cell Death Ligand in Cutaneous Squamous Cell Carcinoma and Treatment of Locally Advanced Disease With Pembrolizumab.
    JAMA Dermatol 2017 Apr;153(4):299-303
    Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York.
    Importance: Limited therapies are available in patients with inoperable locally advanced cutaneous squamous cell carcinoma (cSCC).

    Objective: To determine the efficacy of programmed cell death 1 receptor (PD-1) inhibitors in locally advanced cSCC.

    Design, Setting, And Participants: A single patient with locally advanced cSCC who declined surgery and radiotherapy underwent treatment with pembrolizumab, an anti-PD-1 antibody, at an academic dermatologic surgery section and cancer center. Read More

    Association of Oncogenic Mutations in Patients With Advanced Cutaneous Squamous Cell Carcinomas Treated With Cetuximab.
    JAMA Dermatol 2017 Apr;153(4):291-298
    Department of Dermatology, University Hospital of Nice, France.
    Importance: Cetuximab was recently proposed for advanced cutaneous squamous cell carcinomas (cSCC); however, its efficacy is inconsistent and identification of predictive biomarkers for response is necessary.

    Objective: To search for somatic mutations of the HRAS, KRAS, NRAS, BRAF, and EGFR genes in patients with advanced cSCC treated with cetuximab; and to investigate the efficacy and tolerance of cetuximab according to these mutations.

    Design, Setting, And Participants: A multicentric and retrospective study of 31 patients (22 men, 9 women) with histologically confirmed advanced cSCC carried out in 1 department of dermatology and 2 departments of medical oncology in France between January 2008 and December 2014. Read More

    Ocular Adnexal Reconstruction for Cutaneous Periocular Malignancies.
    Semin Plast Surg 2017 Feb;31(1):22-30
    Oculoplastic and Orbital Surgery, Morgenstern Center for Orbital and Facial Plastic Surgery, Wayne, Pennsylvania.
    Although the majority of lesions present in the periocular region are benign, periocular cutaneous malignancies are certainly not uncommon and must be considered. The management of nonmelanoma cutaneous malignancies is predominately surgical with Mohs micrographic surgery or excision with frozen sections. The approach to reconstruction of the resulting defects depends on the defect location and size. Read More

    Locally advanced colon cancer with cutaneous invasion: case report.
    BMC Res Notes 2017 Mar 1;10(1):113. Epub 2017 Mar 1.
    Department of General Surgery, Centro Hospitalar Trás-os-Montes e Alto Douro, Avenida da Noruega, Lordelo, 5000-508, Vila Real, Portugal.
    Background: Locally advanced colon cancer with direct abdominal wall and skin invasion is an extremely rare finding with most data being derived from case reports, historical autopsy-based or single-center retrospective studies. We present a unique case of a colon cancer with direct cutaneous invasion and colocutaneous fistulization.

    Case Presentation: Eighty-six year old Caucasian female with multiple comorbidities, referred to Surgical Consultation due to ulcerated skin lesion in the abdomen. Read More

    miR-155 promotes cutaneous wound healing through enhanced keratinocytes migration by MMP-2.
    J Mol Histol 2017 Apr 28;48(2):147-155. Epub 2017 Feb 28.
    Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an, 710032, Shaanxi, China.
    Inflammation, re-epithelization and tissue remodeling are three essential steps during wound healing. The re-epithelization process plays the most important role which mainly involves keratinocyte proliferation and migration. miR-155 has been reported to participate in cell migration and transformation, however, its function in skin wound healing is largely unknown. Read More

    Consideration of Muscle Depth for Botulinum Toxin Injections: A Three-Dimensional Approach.
    Plast Surg Nurs 2017 Jan/Mar;37(1):32-38
    Julie Bass Kaplan, MSN, RN, CPSN, CANS, PHN, HCMT, works for Allergan as an ACE speaker/trainer, Scientiae Palette Resources as a speaker/trainer, and is a regional trainer for CosmoFrance, DermaSculpt MicroCannulas. She is the founder of Disappearing Act Laser & Skin Rejuvenation, Redding, CA. She also owns Allergan stock.
    Knowledge of variable anatomy is key for excellent outcomes from the administration of botulinum toxin for aesthetic purposes. One must understand the location and function of each facial muscle to predict the patient's desired outcome. One concept often overlooked by injectors is the understanding of the target muscle's depth. Read More

    Diet phytochemicals and cutaneous carcinoma chemoprevention: A review.
    Pharmacol Res 2017 May 24;119:327-346. Epub 2017 Feb 24.
    Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. Electronic address:
    Cutaneous carcinoma, which has occupied a peculiar place among worldwide populations, is commonly responsible for the considerably increasing morbidity and mortality rates. Currently available medical procedures fail to completely avoid cutaneous carcinoma development or to prevent mortality. Cancer chemoprevention, as an alternative strategy, is being considered to reduce the incidence and burden of cancers through chemical agents. Read More

    Rare association of congenital penile urethrocutaneous fistula with Y-type urethral duplication.
    BMJ Case Rep 2017 Feb 24;2017. Epub 2017 Feb 24.
    Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.
    A 24-year-old man presented with symptoms of difficulty in passage of urine, mixed with gas and stool from penoscrotal junction since birth. He had a history of surgery (posterior sagittal anorectoplasty) for imperforate anus in first week of his life. On physical examination, external meatus was adequate with small 5×5 mm fistulous opening noted at penoscrotal junction with normal anal tone and opening. Read More

    Free serratus anterior artery perforator flap: a case report with an anatomic and radiological study.
    Surg Radiol Anat 2017 Feb 24. Epub 2017 Feb 24.
    Department of Hand Surgery, Plastic Surgery, Burn Surgery, CHU University of Bordeaux, Centre François-Xavier-Michelet, Groupe Hospitalier Pellegrin, Place Amélie-Raba-Léon, 33076, Bordeaux, France.
    Perforator flaps have become very popular in reconstructive surgery. The thoracodorsal and lateral thoracic artery perforator flaps are highly studied, and successful clinical series have been reported, whereas the literature concerning the lateral intercostal and serratus anterior artery perforator flaps is quite poor and their vascular anatomy needs yet to be clarified. We describe a case of free serratus anterior artery perforator flap for the reconstruction of a dorsal defect of the foot, followed by an anatomic and radiological study. Read More

    Exosomes derived from human amniotic epithelial cells accelerate wound healing and inhibit scar formation.
    J Mol Histol 2017 Apr 22;48(2):121-132. Epub 2017 Feb 22.
    Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shannxi, China.
    Wound healing is a highly orchestrated physiological process consisting of a complex events, and scarless wound healing is highly desired for the development and application in clinical medicine. Recently, we have demonstrated that human amniotic epithelial cells (hAECs) promoted wound healing and inhibited scar formation through a paracrine mechanism. However, exosomes (Exo) are one of the most important paracrine factors. Read More

    Primary cutaneous diffuse large B cell lymphoma-other successfully treated by the combination of R-CHOP chemotherapy and surgery: A case report and review of literature.
    Medicine (Baltimore) 2017 Feb;96(8):e6161
    aDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, School of Medicine bDepartment of Pathology, Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Xi'an Jiaotong University, School of Medicine, Xi'an, China.
    Rationale: The occurrence of primary cutaneous diffuse large B cell lymphoma-other (PCDLBCL-O) has been rarely reported in the literature. Its diagnosis is based on histopathological and immunohistochemical examinations. To improve the clinical diagnosis and treatment for PCDLBCL-O, we report a case of PCDLBCL-O successfully treated by the combination of R-CHOP (A chemotherapy protocol consists of cyclophosphamide, doxorubicin, vincristine, prednisone plus Rituximab) chemotherapy and surgery. Read More

    FKBP51 Immunohistochemical Expression: A New Prognostic Biomarker for OSCC?
    Int J Mol Sci 2017 Feb 18;18(2). Epub 2017 Feb 18.
    Department of Advanced Biomedical Sciences, University "Federico II", 80131 Naples, Italy.
    Up-to-date, several molecular markers of prognosis have been studied in Oral Squamous Cell Carcinoma (OSCC), but none entered in the clinical setting. Therapy of OSCC tumors mainly relies on surgery, radiotherapy and partially on chemotherapy; there is an urgent need for biomarkers able to better stratify OSCC patients' risk to address targeted therapeutic strategies. The role of immune response in the pathogenesis and biological behavior of OSCC has been investigated by several authors, and promising results have been obtained with immune checkpoint inhibitors. Read More

    Effects of Remote Ischemic Preconditioning on Heme Oxygenase-1 Expression and Cutaneous Wound Repair.
    Int J Mol Sci 2017 Feb 17;18(2). Epub 2017 Feb 17.
    Department of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands.
    Skin wounds may lead to scar formation and impaired functionality. Remote ischemic preconditioning (RIPC) can induce the anti-inflammatory enzyme heme oxygenase-1 (HO-1) and protect against tissue injury. We aim to improve cutaneous wound repair by RIPC treatment via induction of HO-1. Read More

    Transcutaneous carbon dioxide application accelerates muscle injury repair in rat models.
    Int Orthop 2017 May 16;41(5):1007-1015. Epub 2017 Feb 16.
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
    Purpose: Skeletal muscle injuries are commonly observed in sports and traumatology medicine. Previously, we demonstrated that transcutaneous application of carbon dioxide (CO2) to lower limbs increased the number of muscle mitochondria and promoted muscle endurance. Therefore, we aimed to investigate whether transcutaneous CO2 application could enhance recovery from muscle injury. Read More

    Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance.
    Hum Mol Genet 2017 Apr;26(8):1552-1564
    Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, London E1 2AT, UK.
    Solid tumours have oxygen gradients and areas of near and almost total anoxia. Hypoxia reduces sensitivity to 5-fluorouracil (5-FU)-chemotherapy for colorectal cancer (CRC). MicroRNAs (miRNAs) are hypoxia sensors and were altered consistently in six CRC cell lines (colon cancer: DLD-1, HCT116 and HT29; rectal cancer: HT55, SW837 and VACO4S) maintained in hypoxia (1 and 0. Read More

    Resection of Gastrointestinal Metastases in Stage IV Melanoma: Correlation with Outcomes.
    Am Surg 2016 Nov;82(11):1109-1116
    Department of Cutaneous Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
    The prognosis of patients with gastrointestinal (GI) melanoma metastases is poor. Surgery renders select patients disease free and/or palliates symptoms. We reviewed our single-institution experience of resection with GI melanoma metastases. Read More

    Lateral femoral cutaneous nerve transposition: Renaissance of an old concept in the light of new anatomy.
    Clin Anat 2017 Apr;30(3):409-412
    Department of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, Madison, Wisconsin, 53792.
    Meralgia paresthetica causes pain in the anterolateral thigh. Most surgical procedures involve nerve transection or decompression. We conducted a cadaveric study to determine the feasibility of lateral femoral cutaneous nerve (LFCN) transposition. Read More

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