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    Tumor model for surgical simulation to assess a minimally invasive endoscopic approach for midcheek mass removal.
    Surg Oncol 2017 Sep 27;26(3):286-289. Epub 2017 May 27.
    Department of Maxillofacial Surgery, University of Naples "Federico II", Naples, Italy.
    Introduction: The midcheek is considered one of the most important facial area due to its involvement in mimic expression and communication. Pathology of this district is complex due to the variety of soft tissue belonging to the face. We propose a surgical simulation, to assess the feasibility of a new minimally invasive endoscopic approach for midcheek mass removal. Read More

    The surgical anatomy of the vascularized lateral thoracic artery lymph node flap-A cadaver study.
    J Surg Oncol 2017 Aug 7. Epub 2017 Aug 7.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
    Background: One promising surgical treatment of lymphedema is the VLNT. Lymph nodes can be harvested from different locations; inguinal, axillary, and supraclavicular ones are used most often. The aim of our study was to assess the surgical anatomy of the lateral thoracic artery lymph node flap. Read More

    Radiological anatomy of the perforators of the gluteal region: The "radiosome" based anatomy.
    Microsurgery 2017 Aug 2. Epub 2017 Aug 2.
    Institute of Human Anatomy, Department of Neuroscience, University of Padova, Italy.
    Background: The superior (SGA) and the inferior gluteal artery (IGA) perforator flaps are widely used in pressure-sore repair and in breast reconstruction. The aim was to exhaustively depict the topographical anatomy of the whole system of perforators in the buttock.

    Methods: Eighty lower-extremity computed tomographic angiography (CTA) of patients (20 males/20 females, mean age 61-years old, range 38-81) were considered. Read More

    Anatomy of the medial antebrachial cutaneous nerve and its significance in ulnar nerve surgery: An anatomical study.
    J Plast Reconstr Aesthet Surg 2017 Jun 28. Epub 2017 Jun 28.
    Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Auenbruggerplatz 29/4, 8036 Graz, Austria.
    Background: During cubital tunnel surgery, the medial antebrachial cutaneous nerve (MACN) may be injured, causing painful scars, neuromas, hypaesthesia or hyperalgesia. As the literature on the anatomy of crossing branches in this area is contradictory, this study aimed to re-examine the anatomy of the MACN in this region.

    Methods: Forty upper limbs were dissected. Read More

    Vascularized ulnar periosteal pedicled flap for forearm reconstruction: Anatomical study and a case report.
    Microsurgery 2017 Jul 26. Epub 2017 Jul 26.
    Orthopedic Surgery Department, Pediatric Upper Extremity Surgery and Microsurgery, Hospital Sant Joan de Deu. Passeig Sant Joan de Deu, 2, Esplugues de Llobregat, 08950, Spain.
    Purpose: Through an anatomical review, the aim of this study is to define the ulnar periosteal branches of the posterior interosseous vessels (PIV). In addition, we report the clinical utility of a vascularized ulnar periosteal pedicled flap (VUPPF), supplied by the investigated PIV, in a complex case of radial nonunion.

    Methods: Ten upper limbs latex colored from fresh human cadavers were used. Read More

    Feasibility of Postoperative Radiotherapy Using Conventional Fractionation for Lymph Node Metastasis from Cutaneous Melanoma.
    Anticancer Res 2017 Aug;37(8):4239-4246
    Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    Aim: In the present study we assessed if postoperative radiotherapy (PORT) using conventional fractionation confers a benefit in cutaneous melanoma patients with lymph node (LN) metastasis.

    Patients And Methods: Sixty-two patients with axillary or inguinal LN metastasis were retrospectively reviewed. Twenty-eight patients received PORT. Read More

    Review of the Nomenclature of the Retaining Ligaments of the Cheek: Frequently Confused Terminology.
    Arch Plast Surg 2017 Jul 15;44(4):266-275. Epub 2017 Jul 15.
    Area88 Plastic Surgery Clinic, Seoul, Korea.
    Since the time of its inception within facial anatomy, wide variability in the terminology as well as the location and extent of retaining ligaments has resulted in confusion over nomenclature. Confusion over nomenclature also arises with regard to the subcutaneous ligamentous attachments, and in the anatomic location and extent described, particularly for zygomatic and masseteric ligaments. Certain historical terms-McGregor's patch, the platysma auricular ligament, parotid cutaneous ligament, platysma auricular fascia, temporoparotid fasica (Lore's fascia), anterior platysma-cutaneous ligament, and platysma cutaneous ligament-delineate retaining ligaments of related anatomic structures that have been conceptualized in various ways. Read More

    Malignant melanoma misdiagnosed as diabetic foot ulcer: A case report.
    Medicine (Baltimore) 2017 Jul;96(29):e7541
    aDepartment of Endocrinology and Metabolism bHealth Management Center cDiabetic Foot Care Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
    Rationale: Acral lentiginous melanoma (AML) does not exhibit the classic signs of malignant melanoma. ALM is frequently misdiagnosed because of its unusual sites and atypical clinical morphologies, which lead to poor prognosis.

    Patient Concerns: A female patient aged 78 years was presented to our center with two ulcers on her right foot. Read More

    Lady with wings: a case report of giant neurofibromatosis type I.
    Medicine (Baltimore) 2017 Jul;96(29):e7523
    Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, P.R. China.
    Rationale: Neurofibromatosis type I (NF-I) accounts for approximately 90% of neurofibromatosis. NF-I is an autosomal dominant genetic disease which results from the gene mutation of NF-I situated in chromosome 17q11.2. Read More

    X-shaped inferior extensor retinaculum and its doubtful use in the Bröstrom-Gould procedure.
    Knee Surg Sports Traumatol Arthrosc 2017 Jul 14. Epub 2017 Jul 14.
    Human Anatomy Unit, Department of Pathology and Experimental Therapeutics, School of Medicine, University of Barcelona, C/FeixaLlarga, s/n, 09806, Hospitalet de Llobregat, Barcelona, Spain.
    Purpose: The inferior extensor retinaculum (IER) is an aponeurotic structure located in the anterior aspect of the ankle. According to the literature, it can be used to reinforce a repair of the anterior talofibular ligament in ankle instability. Despite its usual description as an Y-shaped structure, it is still unclear which part of the retinaculum is used for this purpose, or if it is instead the crural fascia that is being used. Read More

    Parry Romberg Syndrome and linear facial scleroderma: management in pediatric population.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):131-138
    Maxillofacial and Dental Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.
    Among all different types of cutaneous scleroderma, Parry Romberg syndrome and linear scleroderma “en coup de sabre” typically involve the visage. Gradual degeneration of the tissues, from the skin up to the bone, is the stigmata of the diseases and the range of clinical manifestations is wide. They typically start during childhood and slowly progress before stabilizing. Read More

    The Physiology and Biomechanics of Skin Flaps.
    Facial Plast Surg Clin North Am 2017 Aug 30;25(3):303-311. Epub 2017 May 30.
    Facial Plastic and Reconstructive Surgery, Carl R. Darnall Army Medical Center, 36065 Santa Fe Avenue, Fort Hood, TX 76544, USA; Department of Surgery, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road #A3007, Bethesda, MD 20814, USA. Electronic address:
    Facial skin defects created by Mohs micrographic surgery are commonly reconstructed using local cutaneous flaps from surrounding skin. To provide optimal survival and aesthetic outcomes, the cutaneous surgeon must command a thorough understanding of the complex vascular anatomy and physiology of the skin as well as the imperative physiologic and biomechanical considerations when elevating and transferring tissue via local skin flaps. Read More

    Staying Out of Double-Bubble and Bottoming-Out Deformities in Dual-Plane Breast Augmentation: Anatomical and Clinical Study.
    Aesthetic Plast Surg 2017 Jun 27. Epub 2017 Jun 27.
    Department of Plastic and Reconstructive Surgery, Università Cattolica del "Sacro Cuore" - University Hospital "A. Gemelli", Largo A. Gemelli 8, 00168, Rome, Italy.
    Background: Double-bubble and bottoming-out deformities represent the second most common reason for revision surgery in breast augmentation. Etiopathogenesis of these complications is still unclear. The aim of this paper is to report our findings in breast cadaver dissections focusing on the inframammary fold (IMF) applied anatomy and to critically review our ten-year experience in breast augmentation. Read More

    [Effects of hypoxia on the phenotype transformation of human dermal fibroblasts to myofibroblasts and the mechanism].
    Zhonghua Shao Shang Za Zhi 2017 Jun;33(6):368-373
    Burn Center of PLA, Department of Burns and Cutaneous Surgery, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China.
    Objective: To investigate the effects of hypoxia on the phenotype transformation of human dermal fibroblasts to myofibroblasts and the mechanism. Methods: The third passage of healthy adult human dermal fibroblasts in logarithmic phase were cultured in DMEM medium containing 10% fetal bovine serum for the following five experiments. (1) In experiments 1, 2, and 3, cells were divided into normoxia group and hypoxia group according to the random number table, with 10 dishes in each group. Read More

    [Effects of activating silent information regulator 1 on early kidney damage in rats with severe burn].
    Zhonghua Shao Shang Za Zhi 2017 Jun;33(6):344-348
    Burn Center of PLA, Department of Burns and Cutaneous Surgery, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China.
    Objective: To investigate the effects of activating silent information regulator 1 (SIRT1) on the early kidney damage in rats with severe burn. Methods: Thirty healthy male SD rats were divided into sham injury group (SI), pure burn group (PB), and SIRT1 activator group (SA) according to the random number table, with 10 rats in each group. Rats in groups PB and SA were inflicted with 30% total body surface area full-thickness scald (hereinafter referred to as burn) on the back. Read More

    Tumor Metabolism in the Microenvironment of Nodal Metastasis in Oral Squamous Cell Carcinoma.
    Otolaryngol Head Neck Surg 2017 Jun 1:194599817709224. Epub 2017 Jun 1.
    4 Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
    Objective In many cancers, including head and neck squamous cell carcinoma (HNSCC), different regions within a tumor have different metabolic phenotypes. Transfer of metabolites between compartments promotes tumor growth and aggressive behavior. Metabolic compartmentalization in HNSCC nodal metastases has not been studied, nor has its impact on extracapsular extension or clinical outcomes been determined. Read More

    Transverse Cervical Artery Perforator Flap: Standardized Surgical Technique and Multiple Reconstructive Opportunity in Head and Neck Surgery.
    Ann Plast Surg 2017 Jun 9. Epub 2017 Jun 9.
    From the *Department of Clinical Sciences and Community Health, San Giuseppe Hospital-Multimedica Group, Università degli Studi di Milano, Milan, Italy; and †Department of Human Anatomy and Histology, Universidad Miguel Hernández de Alicante, Spain.
    The main purpose of head and neck reconstructive surgery is to provide anatomic restoration of the demolited region and to provide preservation and recovery of function. The anatomical investigations conducted over the years has enabled a detailed knowledge of human body vascularization, giving the opportunity to design and harvest more and more versatile and refined flaps, with increasingly satisfactory results. Even if in the last 2 decades free flaps have been considered a reconstructive criterion standard, they still determine a great physical impact for the patient and require a certain surgical experience. Read More

    Aberrant Cutaneous Nerve Loops in the Axilla.
    Acta Medica (Hradec Kralove) 2017;60(1):51-54
    Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
    During routine dissection classes, conducted for first year undergraduate medical students, we encountered a rare anatomical variation in relation to the intercostobrachial nerve (ICBN). The ICBN represents the lateral undivided cutaneous branch of second intercostal nerve. In this case, the ICBN formed nerve loops with branches of the lateral cutaneous branch of the third intercostal nerve. Read More

    Using a Thermal Imaging Camera to Locate Perforators on the Lower Limb.
    Arch Plast Surg 2017 May 22;44(3):243-247. Epub 2017 May 22.
    School of Medicine, University of Queensland, Brisbane, New Zealand.
    Reconstruction of the lower limb presents a complex problem after skin cancer surgery, as proximity of skin and bone present vascular and technical challenges. Studies on vascular anatomy have confirmed that the vascular plane on the lower limb lies deep to the deep fascia. Yet, many flaps are routinely raised superficial to this plane and therefore flap failure rates in the lower limb are high. Read More

    Anatomy of the cutaneous lymphatic system of the trunk: a clinico-anatomical study of 90 cutaneous melanomas.
    Surg Radiol Anat 2017 May 29. Epub 2017 May 29.
    Rouen University, Rouen Cedex 1, France.
    Purpose: The cutaneous lymphatic system of the trunk is a complex network, the anatomical knowledge of which remains unclear. The lymphatic system plays a major role in the dissemination of lymphophilic cancers like melanomas. The aim of this study was to improve our knowledge, optimize the care of patients with cutaneous tumors of the trunk, and to use our clinical experience of the topography of pathologic lymph nodes related to cutaneous melanomas and depicted by lymphoscintigraphy. Read More

    Snail mucus - glandular origin and composition in Helix pomatia.
    Zoology (Jena) 2017 Jun 5;122:126-138. Epub 2017 May 5.
    Core Facility Cell Imaging and Ultrastructure Research, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, A-1200 Vienna, Austria. Electronic address:
    Apart from their well-known culinary use, gastropod species such as Helix, which have a hydrogel-like mucus, are increasingly being exploited for cosmetic, bioengineering and medical applications. However, not only are the origin and composition of these "sticky" secretions far from being fully characterized, the number and morphology of the mucus glands involved is also uncertain. This study aims to characterize in detail the cutaneous glands of the Helix pomatia foot on morphological, histochemical and immunohistochemical levels. Read More

    Platelet-released growth factors induce psoriasin in keratinocytes: Implications for the cutaneous barrier.
    Ann Anat 2017 Sep 25;213:25-32. Epub 2017 May 25.
    Department of Dermatology, University Hospital of Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 7, 24105 Kiel, Germany.
    Millions of patients around the world suffer minor or major extremity amputation due to progressive wound healing complications of chronic or infected wounds, the therapy of which remains a challenge. One emerging therapeutic option for the treatment of these complicated wounds is the local application of an autologous thrombocytes concentrate lysate (e.g. Read More

    Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma.
    Oncotarget 2017 Jul;8(28):45825-45836
    Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.
    Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Inflammation is a typical feature in cSCC progression. Analysis of the expression of inflammasome components in cSCC cell lines and normal human epidermal keratinocytes revealed upregulation of the expression of AIM2 mRNA and protein in cSCC cells. Read More

    Multiple Visceral Resections for Synchronous Left and Transverse Colon Adenocarcinoma with Gastrocolic-cutaneous Fistula - Case Report and Literature Review.
    Anticancer Res 2017 05;37(5):2601-2607
    Department of General Surgery, Ponderas Academic Hospital, Bucharest, Romania.
    Synchronous adenocarcinomas of the colon represent a rare situation, characterized by the presence of at least two colonic malignancies separated by at least 4-cm distance, in the absence of submucosal spread. Gastrocolic-cutaneous fistulas also represent a rare complication associated with the presence of colonic or gastric adenocarcinomas. We present the case of a 61-year-old patient who presented for abdominal pain, vomiting, weight loss and cutaneous exteriorization of purulent liquid. Read More

    Use of fat transfer to treat a chronic, non-healing, post-radiation ulcer: a case study.
    J Wound Care 2017 May;26(5):272-273
    Consultant Plastic and Reconstructive Surgeon.
    Objective: Problematic wound healing and ulceration in radiation-damaged tissue is a surgical challenge. Clinical studies have shown that grafting fat tissue in an irradiated area can improve the quality of the skin and has regenerative effects. This case study describes how fat transfer led to the healing of a chronic ulcer resistant to other forms of treatment. Read More

    Outlier Practice Patterns in Mohs Micrographic Surgery: Defining the Problem and a Proposed Solution.
    JAMA Dermatol 2017 Jun;153(6):565-570
    The Skin Surgery Center, Winston-Salem, North Carolina11Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
    Importance: Outlier physician practices in health care can represent a significant burden to patients and the health system.

    Objective: To study outlier physician practices in Mohs micrographic surgery (MMS) and the associated factors.

    Design, Setting, And Participants: This retrospective analysis of publicly available Medicare Part B claims data from January 2012 to December 2014 includes all physicians who received Medicare payments for MMS from any practice performing MMS on the head and neck, genitalia, hands, and feet region of Medicare Part B patients. Read More

    Utility of a Noninvasive 2-Gene Molecular Assay for Cutaneous Melanoma and Effect on the Decision to Biopsy.
    JAMA Dermatol 2017 Jul;153(7):675-680
    Department of Dermatology, Northwestern University, Chicago, Illinois.
    Importance: Expression of long intergenic non-protein coding RNA 518 (LINC00518) and preferentially expressed antigen in melanoma (PRAME) genes, obtained via noninvasive adhesive patch biopsy, is a sensitive and specific method for detection of cutaneous melanoma. However, the utility of this test in biopsy decisions made by dermatologists has not been evaluated.

    Objective: To determine the utility of the pigmented lesion assay (PLA) for LINC00518/PRAME expression in decisions to biopsy a series of pigmented skin lesions. Read More

    Improvement of Flap Necrosis in a Rat Random Skin Flap Model by In Vivo Electroporation-Mediated HGF Gene Transfer.
    Plast Reconstr Surg 2017 May;139(5):1116e-1127e
    Bern, Switzerland Department of Dermatology, and the Department of Pulmonary Medicine, Inselspital, Bern University Hospital; and the Department of Clinical Research and the Graduate School for Cellular and Biomedical Sciences, University of Bern.
    Background: Despite great understanding of underlying mechanisms for flap necrosis and advances in surgical techniques, flap necrosis remains a critical issue. In the present study, the authors investigated the efficacy of electroporation-mediated hepatocyte growth factor (HGF) gene delivery to random dorsal skin flaps (McFarlane) to accelerate wound healing and reduce flap necrosis.

    Methods: Fifteen male Wistar rats (290 to 320 g) were divided randomly into three groups. Read More

    Surgical Techniques for Closure of a Scalp Defect After Resection of Skin Malignancy.
    Dermatol Surg 2017 May;43(5):715-723
    *All authors are affiliated with the Department of Head and Neck Cancer, Maria Skłodowska Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.
    Background: Surgery for scalp malignancies is aimed at the complete resection and a good aesthetic outcome. The goal was to develop an algorithm for scalp reconstruction based on the authors' surgical experience.

    Methods: This is a retrospective analysis of 123 procedures of scalp malignancies in 105 patients. Read More

    Origin, Branching, and Communications of the Intercostobrachial Nerve: a Meta-Analysis with Implications for Mastectomy and Axillary Lymph Node Dissection in Breast Cancer.
    Cureus 2017 Mar 17;9(3):e1101. Epub 2017 Mar 17.
    Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
    The intercostobrachial nerve (ICBN), which usually originates from the lateral cutaneous branch of the second intercostal nerve, innervates areas of the axilla, lateral chest, and medial arm. It is at risk for injury during operative procedures that are often used in the management of breast cancer and such injury has been associated with postoperative sensory loss and neuropathic pain, decreasing the quality of life. PubMed, Excerpta Medica Database (EMBASE), ScienceDirect, Google Scholar, China National Knowledge Infrastructure (CNKI), Scientific Electronic Library Online (SciELO), Biosciences Information Service (BIOSIS), and Web of Science were searched comprehensively. Read More

    Comparison of Efficacy and Safety Between Propranolol and Steroid for Infantile Hemangioma: A Randomized Clinical Trial.
    JAMA Dermatol 2017 Jun;153(6):529-536
    Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea.
    Importance: There are limited data from randomized clinical trials comparing propranolol and steroid medication for treatment of infantile hemangioma (IH).

    Objective: To determine the efficacy and safety of propranolol compared with steroid as a first-line treatment for IH.

    Design, Setting, And Participants: This randomized clinical noninferiority trial tested the efficacy and safety of propranolol vs steroid treatment for IH at a single academic hospital. Read More

    Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.
    PLoS One 2017 19;12(4):e0175755. Epub 2017 Apr 19.
    The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Australia.
    Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Read More

    Management of the extensive thoracic defects after deep sternal wound infection with the rectus abdominis myocutaneous flap: A retrospective case series.
    Medicine (Baltimore) 2017 Apr;96(16):e6391
    aDepartment of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University bXi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
    Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wound management, especially when 1 or 2 internal mammary arteries were absent. Read More

    Droplet digital PCR (ddPCR) vs quantitative real-time PCR (qPCR) approach for detection and quantification of Merkel cell polyomavirus (MCPyV) DNA in formalin fixed paraffin embedded (FFPE) cutaneous biopsies.
    J Virol Methods 2017 Aug 14;246:15-20. Epub 2017 Apr 14.
    Department of Experimental and Clinical Medicine, University of Florence, Italy. Electronic address:
    Background: Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma and high viral load in the skin was proposed as a risk factor for the occurrence of this tumour. MCPyV DNA was detected, with lower frequency, in different skin cancers but since the viral load was usually low, the real prevalence of viral DNA could be underestimated.

    Objective: To evaluate the performance of two assays (qPCR and ddPCR) for MCPyV detection and quantification in formalin fixed paraffin embedded (FFPE) tissue samples. Read More

    Is pelvic sentinel node biopsy necessary for lower extremity and trunk melanomas?
    Am J Surg 2017 May 27;213(5):921-925. Epub 2017 Mar 27.
    Department of Surgery, Division of Surgical Oncology, Oregon Health & Science University, Portland, OR, USA.
    Objective: There is currently no consensus regarding how to address pelvic sentinel lymph nodes (PSLNs) in melanoma. Thus, our objectives were to identify the incidence and clinical impact of PSLNs.

    Methods: Retrospective review of a prospectively collected multi-institutional melanoma database. Read More

    Malignant Melanoma in African-Americans: A Population-Based Clinical Outcomes Study Involving 1106 African-American Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1988-2011).
    Medicine (Baltimore) 2017 Apr;96(15):e6258
    aDepartment of Surgery, Saint Barnabas Medical Center, Livingston, NJ bSaint George's University School of Medicine, Grenada, West Indies cDepartment of Surgery, New Jersey Medical School, Rutgers University, Newark, NJ dDepartment of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ.
    Malignant melanoma accounts for 75% of all skin cancer deaths and is potentially curable if identified early. Although melanoma is rare in African-Americans (AA), it is associated with a worse prognosis than in Caucasians. This study examines the demographic, pathologic, and clinical factors impacting AA melanoma outcomes. Read More

    FIBRIN GEL AS A SCAFFOLD FOR SKIN SUBSTITUTE--PRODUCTION AND CLINICAL EXPERIENCE.
    • Authors:
    Acta Clin Croat 2016 Jun;55(2):279-89
    The purpose of this study was to create a fibrin-based human skin substitute in vitro with epidermal and dermal component and to assess its healing potential in deep partial and full thickness burns. Fibrin scaff olds were prepared from commercial fibrin glue kits. Human fibroblasts were cultured in fibrin gel. Read More

    Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration.
    Aesthet Surg J 2017 05;37(suppl_1):S20-S31
    Director and Founder of Toxin Science Limited, Wrexham, UK.
    Time to onset of response and duration of response are key measures of botulinum toxin efficacy that have a considerable influence on patient satisfaction with aesthetic treatment. However, there is no overall accepted definition of efficacy for aesthetic uses of botulinumtoxinA (BoNT-A). Mechanical methods of assessment do not lend themselves to clinical practice and clinicians rely instead on assessment scales such as the Frontalis Activity Measurement Standard, Frontalis Rating Scale, Wrinkle Severity Scale, and Subject Global Assessment Scale, but not all of these have been fully validated. Read More

    Surgical Treatment of Subungual Squamous Cell Carcinoma by Wide Excision of the Nail Unit and Skin Graft Reconstruction: An Evaluation of Treatment Efficiency and Outcomes.
    JAMA Dermatol 2017 May;153(5):442-448
    Department of Dermatology, Centre Hospitalier Lyon Sud, Pierre-Bénite, France2Health Department, Université Claude Bernard Lyon 1, Lyon, France3Lyons Cancer Research Center, Lyon, France.
    Importance: The best surgical treatment modalities for subungual squamous cell carcinoma (SUSCC) without bone invasion need to be determined. The limited available data on Mohs micrographic surgery do not demonstrate its use as a standard procedure. A previous study in a limited series of patients has shown that wide surgical excision of the nail unit was associated with a low rate of recurrence. Read More

    Sustained attractiveness and natural youthful appearance by upper lip rejuvenation : Minimally invasive procedures to combat facial aging.
    Wien Med Wochenschr 2017 Apr 5. Epub 2017 Apr 5.
    Clinica Goldman, Porto Alegre/RS, Brazil.
    Facial aging is a complex process individualized by interaction with exogenous and endogenous factors. The upper lip is one of the facial components by which facial attractiveness is defined. Upper lip aging is significantly influenced by maxillary bone and teeth. Read More

    Randomized clinical trial of autologous skin cell suspension for accelerating re-epithelialization of split-thickness donor sites.
    Br J Surg 2017 Jun 5;104(7):836-842. Epub 2017 Apr 5.
    Department of Burn Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
    Background: Split-thickness skin graft (STSG) is used frequently, but may result in complications at the donor site. Rapid healing of donor-site wounds is critical to relieving morbidity. This study investigated whether autologous skin cell suspension could improve healing of STSG donor-site wounds. Read More

    A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities.
    Int J Mol Sci 2017 Apr 3;18(4). Epub 2017 Apr 3.
    State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China.
    The seeds of Strychnosnux-vomica L., as a traditional Chinese medicine, have good anti-inflammatory and analgesic activities. However, it usually leads to gastrointestinal irritation and systemic toxicity via oral administration. Read More

    Restoration of basic hand function following devastating hand injuries using a microsurgically fabricated chimeric iliac osteocutaneous flap.
    J Plast Reconstr Aesthet Surg 2017 Jun 21;70(6):723-728. Epub 2017 Mar 21.
    Institute of Orthopedic Trauma Surgery of the Chinese People's Liberation Army, 89th Hospital, Weifang, China.
    Reconstruction following devastating hand injuries, with amputations of the thumb plus multiple digits, is challenging. Double flap or combined flap transfers may be options in such cases. Between 2012 and 2014, 6 patients underwent hand reconstruction following devastating injuries with amputations of the thumb and multiple digits. Read More

    Elective Neck Dissection for Head and Neck Cutaneous Squamous Cell Carcinoma with Skull Base Invasion.
    Otolaryngol Head Neck Surg 2017 Apr 28;156(4):671-676. Epub 2017 Feb 28.
    1 The University of Utah School of Medicine, Otolaryngology Head and Neck Surgery, Salt Lake City, Utah, USA.
    Objectives Skull base invasion from cutaneous squamous cell carcinoma (cSCC) via perineural spread affects survival and the rate of regional metastasis. Our objective is to investigate the factors associated with elective neck dissection (END) in this population and the survival difference with END compared with observation for patients with a cN0 neck. Study Design Case series with chart review. Read More

    European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome - Update 2017.
    Eur J Cancer 2017 May 31;77:57-74. Epub 2017 Mar 31.
    Department of Dermatology, Medical University of Vienna, Vienna, Austria.
    In order to provide a common standard for the treatment of mycosis fungoides (MF) and Sézary syndrome (SS), the European Organisation for Research and Treatment of Cancer-Cutaneous Lymphoma Task Force (EORTC-CLTF) published in 2006 its consensus recommendations for the stage-adapted selection of management options for these neoplasms. Since then, the understanding of the pathophysiology and epidemiology of MF/SS has advanced, the staging system has been revised, new outcome data have been published and novel treatment options have been introduced. The purpose of the present document is to update the original recommendations bearing in mind that there are still only a limited number of controlled studies to support treatment decisions for MF/SS and that often treatment is determined by institutional experience and availability. Read More

    Three-Dimensional (3D) Columellar Strut Graft in Rhinoplasty.
    Aesthet Surg J 2017 04;37(4):398-406
    Assistant Professor, Department of Plastic, Reconstructive, and Aesthetic Surgery, Pamukkale University Hospital, Denizli, Turkey.
    Background: Nasal tip surgery is the most important and most difficult step of an aesthetic rhinoplasty operation. Various suture and grafting techniques have been described for adequate tip rotation and projection in nasal tip surgery.

    Objectives: The author describes his technique of "three-dimensional (3D) columellar strut graft" in nasal tip surgery. Read More

    Trichilemmal cystis in metastatic melanoma: a case report.
    Exp Oncol 2017 03;39(1):86-87
    Department of Dermatology, Department of Critical Care Medicine and Surgery, University of Florence, Firenze 50121, 50132, Italy.
    The malignant melanoma is a neoplasm associated with a wide variety of cutaneous paraneoplastic syndromes, as dermatomyositis, systemic sclerosis, paraneoplastic pemphigus. We describe a case of four multiple trichilemmal cystis arising on frontal region in the same patient with brain metastasis and unknown primary melanoma and discuss their relationship. Read More

    Temporary skin grafts based on hybrid graphene oxide-natural biopolymer nanofibers as effective wound healing substitutes: pre-clinical and pathological studies in animal models.
    J Mater Sci Mater Med 2017 May 30;28(5):73. Epub 2017 Mar 30.
    Department of Materials Science and Engineering, Sharif University of Technology, P.O. Box11155-9161, Azadi Avenue, Tehran, 14588, Iran.
    In recent years, temporary skin grafts (TSG) based on natural biopolymers modified with carbon nanostructures have received considerable attention for wound healing. Developments are required to improve physico-mechanical properties of these materials to match to natural skins. Additionally, in-deep pre-clinical examinations are necessary to ensure biological performance and toxicity effect in vivo. Read More

    Relevant Insertion Site Anatomy of the Conventus Distal Radius System.
    Hand (N Y) 2017 Mar 1:1558944717701239. Epub 2017 Mar 1.
    1 Valley Orthopedic Surgery Residency, Modesto, CA, USA.
    Background: The Conventus Distal Radius System (DRS) is an intramedullary fixation scaffold inserted into the lateral aspect of the distal radius. The purpose of this study was to identify insertion site anatomy to illustrate risks associated with the minimally invasive nature of radial-sided implant application.

    Methods: Ten cadavers were utilized. Read More

    General Guidelines for Quality Assurance of Immunohistochemistry in a Mohs Lab.
    Dermatol Surg 2017 Apr;43(4):507-511
    *Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia;†Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
    Background: The adoption of recently created protocols introduces Mohs laboratories to the principles of immunohistochemistry (IHC) performance validation and clinical laboratory regulations that are unique to these evolving technologies.

    Objective: To review Food and Drug Administration (FDA) IHC reagent classifications, IHC validation protocols, and quality assurance (QA) procedures and documentation needed in conjunction with IHC test guidelines.

    Methods: A focused review of IHC reagent classifications and guidelines in clinical testing laboratories was conducted using PubMed and FDA source documents. Read More

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