5,006,493 results match your criteria Anatomy & cell biology[Journal]

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A microanatomical study of the far lateral approach.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Yijishan Hospital, Wannan Medical College, Wuhu, China. Electronic address:

Objetive: The far-lateral approach (FLA) remains a challenge for neurosurgeons due to the complex anatomy of this region, especially in patients with anatomical variations. There is therefore an urgent need for better quantitative knowledge of the microsurgical anatomy of the FLA.

Methods: The study was performed using the dried skulls and atlas vertebrae of 50 Chinese adults, in which significant clinical parameters were measured. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.004DOI Listing

Carotid sinus nerve: a comprehensive review of its anatomy, variations, pathology, and clinical applications.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Seattle Science Foundation, Seattle, WA, USA; Department of Anatomical Sciences, St. George's University, St. George's, Grenada, West Indies.

The carotid sinus nerve branches off the glossopharyngeal nerve just after its appearance from the jugular foramen, descends along the internal carotid artery, and enters the carotid sinus. There have been many studies of the pathway and the course of the carotid sinus nerve and its communications with surrounding nerves. The intercommunication is exceedingly complicated. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.064DOI Listing

Determinants of structural segregation and patterning in the human cortex.

Neuroimage 2019 Apr 14. Epub 2019 Apr 14.

Department of Anatomy & Neurobiology, University of California, Irvine, USA.

This study aimed at uncovering mechanisms that govern the spatio-temporal patterning of the human cortex and its structural variability, and drawing links between fetal brain development and variability in adult brains. A data-driven analytic approach based on structural MR images revealed the following findings: (1) The cortical surface can be subdivided into 13 independent regions ("communities") based on macroscopic features. (2) Thirty centers of low inter-subject variability were found in major sulci on the cortical surface. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193031
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http://dx.doi.org/10.1016/j.neuroimage.2019.04.031DOI Listing
April 2019
1 Read

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

Cell Rep 2019 Apr;27(3):971-986.e9

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada; Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

Glioblastoma therapies have remained elusive due to limitations in understanding mechanisms of growth and survival of the tumorigenic population. Using CRISPR-Cas9 approaches in patient-derived GBM stem cells (GSCs) to interrogate function of the coding genome, we identify actionable pathways responsible for growth, which reveal the gene-essential circuitry of GBM stemness and proliferation. In particular, we characterize members of the SOX transcription factor family, SOCS3, USP8, and DOT1L, and protein ufmylation as important for GSC growth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193036
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http://dx.doi.org/10.1016/j.celrep.2019.03.047DOI Listing
April 2019
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Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

Cell Rep 2019 Apr;27(3):860-871.e8

Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Inflammation Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Department of Otolaryngology-Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

A truncating mutation in the mouse Srrm4 gene, which encodes a neuronal splicing factor, causes alternative splicing defects selectively in the ear. The mechanism by which splicing is preserved in the brain of these mice is not known. Here, we show that SRRM3 limits the Srrm4 mutation-associated defects to the ear and that, in cortical neurons, overlapping SRRM3-SRRM4 activity regulates the development of interneuronal inhibition. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.072DOI Listing

Transforaminal epidural steroid injection and infraneural approach.

Agri 2019 Apr;31(2):104-106

Department of Anesthesiology and Reanimation, Pain Clinic, Ege University, Izmir, Turkey.

Transforaminal epidural steroid injections are a common intervention in the treatment of radicular pain. Complications are rare, but can be catastrophic. One of the potentially devastating complications is occlusion of the artery of Adamkiewicz (AKA). Read More

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http://www.agridergisi.com/jvi.aspx?pdir=agri&plng=eng&a
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http://dx.doi.org/10.5505/agri.2017.26097DOI Listing
April 2019
1 Read

The Role of Schlemm's Canal Endothelium Cellular Connectivity in Giant Vacuole Formation: A 3D Electron Microscopy Study.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1630-1643

Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States.

Purpose: We investigated whether cellular connectivity between Schlemm's canal (SC) inner wall (IW) endothelium, and juxtacanalicular connective tissue (JCT), and between IW endothelial cells, plays a role in giant vacuole (GV) and pore formation by comparing perfusion- and immersion-fixed eyes.

Methods: Normal human donor eyes (n = 4) were either immersion-fixed (0 mm Hg) or perfusion-fixed (15 mm Hg). Trabecular meshwork near SC was imaged using serial block-face scanning electron microscopy. Read More

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http://dx.doi.org/10.1167/iovs.18-26011DOI Listing
April 2019
4 Reads

Interactive biomedical ontology matching.

PLoS One 2019 17;14(4):e0215147. Epub 2019 Apr 17.

College of Information Science and Engineering, Fujian University of Technology, Fuzhou, Fujian, China.

Due to continuous evolution of biomedical data, biomedical ontologies are becoming larger and more complex, which leads to the existence of many overlapping information. To support semantic inter-operability between ontology-based biomedical systems, it is necessary to identify the correspondences between these information, which is commonly known as biomedical ontology matching. However, it is a challenge to match biomedical ontologies, which dues to: (1) biomedical ontologies often possess tens of thousands of entities, (2) biomedical terminologies are complex and ambiguous. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215147PLOS

A new hadrosauroid (Dinosauria: Ornithopoda) from the Late Cretaceous Baynshire Formation of the Gobi Desert (Mongolia).

PLoS One 2019 17;14(4):e0208480. Epub 2019 Apr 17.

Department of Geosciences, Faculty of Science, Osaka City University, Osaka Prefecture, Osaka, Japan.

A new genus and species of non-hadrosaurid hadrosauroid, Gobihadros mongoliensis, is described from a virtually complete and undeformed skull and postcranial skeleton, as well as extensive referred material, collected from the Baynshire Formation (Cenomanian-Santonian) of the central and eastern Gobi Desert, Mongolia. Gobihadros mongoliensis is the first non-hadrosaurid hadrosauroid from the Late Cretaceous of central Asia known from a complete, articulated skull and skeleton. The material reveals the skeletal anatomy of a proximate sister taxon to Hadrosauridae in remarkable detail. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208480PLOS

Receptor-dependence of BDNF Actions in Superficial Dorsal Horn; Relation to Central Sensitization and Actions of Macrophage Colony Stimulating Factor 1 (CSF-1).

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Neuroscience and Mental Health Institute and Dept. of Pharmacology, University of Alberta, Canada.

Peripheral nerve injury elicits an enduring increase in the excitability of the spinal dorsal horn. This change, which contributes to the development of neuropathic pain, is a consequence of release and prolonged exposure of dorsal horn neurons to various neurotrophins and cytokines. We have shown in rats that nerve injury increases excitatory synaptic drive to excitatory neurons but decreases drive to inhibitory neurons. Read More

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http://dx.doi.org/10.1152/jn.00839.2018DOI Listing

Functional effects of blocking VEGF/VEGFR2 signaling in the rat urinary bladder in acute and chronic CYP-induced cystitis.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Neurological Sciences, University of Vermont, United States.

High expression of vascular endothelial growth factor (VEGF) is associated with immature angiogenesis within the urinary bladder wall and bladder afferent nerve sensitization leading to visceral hyperalgesia and pelvic pain. Research suggests a shift in VEGF alternative splice variant (VEGF-Aa, VEGF-Ab) expression with several pathologies (e.g. Read More

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http://dx.doi.org/10.1152/ajprenal.00083.2019DOI Listing

GLP-1 induces alpha cell proliferation and overrides leptin suppression induced by negative energy balance in vagotomized rats.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Endocrine, Cardiovascular & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

Glucagon-like peptide-1 (GLP-1) influences energy balance by exerting effects on food intake and glucose metabolism, through mechanisms that are partially dependent on the vagal pathway. The aim of this study was to characterize the effects of chronic GLP-1 stimulation on energy homeostasis and glucose metabolism in the absence of vagal innervation Truncal vagotomized (VGX) and sham operated rats (SHAM) received an intraperitoneal GLP-1 infusion (3.5 pmol/kg/min) trough mini-osmotic pumps. Read More

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http://dx.doi.org/10.1002/jcb.28719DOI Listing

Machine-learning identifies parkinson's disease patients based on resting-state between-network functional connectivity.

Br J Radiol 2019 Apr 17:20180886. Epub 2019 Apr 17.

1 Department of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty , Dusseldorf , Germany.

Objectives: Evaluation of a data-driven, model-based classification approach to discriminate idiopathic Parkinson's disease (PD) patients from healthy controls (HC) based on between-network connectivity in whole-brain resting-state functional MRI (rs-fMRI).

Methods: Whole-brain rs-fMRI (EPI/TR = 2.2  s/TE = 30  ms/flip angle = 90°/resolution = 3. Read More

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http://dx.doi.org/10.1259/bjr.20180886DOI Listing

Role of Cardiac Computed Tomography in the Diagnosis of Left Ventricular Myocardial Diseases.

J Cardiovasc Imaging 2019 Apr;27(2):73-92

Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Multimodality imaging is indicated for the evaluation of left ventricular (LV) myocardial diseases. Cardiac magnetic resonance (CMR) allows morphological and functional assessment of the LV along with soft tissue characterization. Technological advances in cardiac computed tomography (CT) have led to the development of techniques for diagnostic acquisition in LV myocardial disease. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4250/jcvi.2019.2
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http://dx.doi.org/10.4250/jcvi.2019.27.e17DOI Listing
April 2019
1 Read

Aluminum chloride causes 5-fluorouracil resistance in hepatocellular carcinoma HepG2 cells.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Public Health, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan.

Chemoresistance is one of the major obstacles in chemotherapy-based hepatocellular carcinoma (HCC) intervention. Aluminum (Al) is an environmental pollutant that plays a vital role in carcinogenesis, tumorigenesis, and metastasis. However, the effect of Al on chemoresistance remains unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28625
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http://dx.doi.org/10.1002/jcp.28625DOI Listing
April 2019
2 Reads

Evolutionary trajectories, accessibility, and other metaphors: the case of C and CAM photosynthesis.

Authors:
Erika J Edwards

New Phytol 2019 Apr 16. Epub 2019 Apr 16.

Department of Ecology and Evolutionary Biology, Yale University, 165 Prospect St, New Haven, CT, 06520-8105, USA.

Are evolutionary outcomes predictable? Adaptations that show repeated evolutionary convergence across the Tree of Life provide a special opportunity to dissect the context surrounding their origins, and identify any commonalities that may predict why certain traits evolved many times in particular clades and yet never evolved in others. The remarkable convergence of C and Crassulacean Acid Metabolism (CAM) photosynthesis in vascular plants makes them exceptional model systems for understanding the repeated evolution of complex phenotypes. This review highlights what we have learned about the recurring assembly of C and CAM, focusing on the increasingly predictable stepwise evolutionary integration of anatomy and biochemistry. Read More

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http://dx.doi.org/10.1111/nph.15851DOI Listing

Climatic adaptation in human inferior nasal turbinate morphology: Evidence from Arctic and equatorial populations.

Am J Phys Anthropol 2019 Apr 16. Epub 2019 Apr 16.

Department of Anthropology, University of Iowa, Iowa City, Iowa.

Objectives: The nasal turbinates directly influence the overall size, shape, and surface area of the nasal passages, and thus contribute to intranasal heat and moisture exchange. However, unlike the encapsulating walls of the nasal cavity, ecogeographic variation in nasal turbinate morphology among humans has not yet been established. Here we investigate variation in inferior nasal turbinate morphology in two populations from climatically extreme environments. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ajpa.23840
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http://dx.doi.org/10.1002/ajpa.23840DOI Listing
April 2019
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Reconstruction of lymphatic vessels in the mouse tail after cupping therapy.

Folia Morphol (Warsz) 2019 Apr 17. Epub 2019 Apr 17.

Department of Anatomy and Physiology, Shandong College of Traditional Chinese Medicine, Yantai, China.

Background: To investigate the regulatory mechanism of local lymphatic reconstruction after cupping therapy in a mouse model.

Materials And Methods: The lymphatic reconstruction process in the mouse tail after cupping therapy as well as the expression levels of the vascular endothelial identification molecule CD34, prospero homeobox protein 1 (PROX1), and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) were investigated for a duration of 4 days through immunohistochemistry experiments.

Results: On day 1 after cupping therapy, the CD34+ and LYVE-1+ cell densities were significantly increased, and the formed CD34+LYVE-1+ tubular structure started to express PROX1. Read More

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https://journals.viamedica.pl/folia_morphologica/article/vie
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http://dx.doi.org/10.5603/FM.a2019.0044DOI Listing
April 2019
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Semi-automatic segmentation and surface reconstruction of CT images by using rotoscoping and warping techniques.

Folia Morphol (Warsz) 2019 Apr 17. Epub 2019 Apr 17.

Department of Emergency Medical Technology, Gachon University of College of Health Science, 119 Hambakmoe-ro, Yeonsu-gu, Incheon 406-799, South Korea, incheon, Korea, Republic Of.

Background: Quick and large-scale segmentation along with three-dimensional (3D) reconstruction is necessary to make precise 3D musculoskeletal models for surface anatomy education, palpation training, medical communication, morphology research, and virtual surgery simulation. However, automatic segmentation of the skin and muscles remain undeveloped.

Materials And Methods: Therefore, in this study, we developed workflows for semi-automatic segmentation and surface reconstruction, using rotoscoping and warping techniques. Read More

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http://dx.doi.org/10.5603/FM.a2019.0045DOI Listing

Pedicle screw navigation using surface digitization on the Microsoft HoloLens.

Int J Comput Assist Radiol Surg 2019 Apr 15. Epub 2019 Apr 15.

Computer Assisted Research and Development Group, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008, Zurich, Switzerland.

Purpose: In spinal fusion surgery, imprecise placement of pedicle screws can result in poor surgical outcome or may seriously harm a patient. Patient-specific instruments and optical systems have been proposed for improving precision through surgical navigation compared to freehand insertion. However, existing solutions are expensive and cannot provide in situ visualizations. Read More

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http://dx.doi.org/10.1007/s11548-019-01973-7DOI Listing

Endoscopic transvestibular anatomy of the infratemporal fossa and upper parapharyngeal spaces for clinical surgery: a cadaver study.

Eur Arch Otorhinolaryngol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otorhinolaryngology-Head and Neck Surgery (Shanghai Key Clinical Disciplines of Otorhinolaryngology), Eye, Ear, Nose and Throat Hospital, Fudan University, Fenyang Road Num83, Xuhui District, Shanghai, 200031, China.

Aims: To investigate the anatomy of the infratemporal fossa (ITF) and to discuss the practicality of endoscopic transvestibular surgery for an ITF tumor.

Methods: Five fresh cadaveric specimens (10 sides) with vascular silicone injection were prepared for endoscopic anatomy. A transvestibular vertical incision was made along the ramus of the mandible, and pivotal nerves, arteries, and muscles were exposed to sculpt the anatomic landmarks of the ITF. Read More

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http://dx.doi.org/10.1007/s00405-019-05410-yDOI Listing

Relationships between differences in the number of fiber bundles of the anterior talofibular ligament and differences in the angle of the calcaneofibular ligament and their effects on ankle-braking function.

Surg Radiol Anat 2019 Apr 16. Epub 2019 Apr 16.

Department of Anatomy, School of Life Dentistry at Niigata, Nippon Dental University, Niigata, Japan.

Purpose: The aim was to clarify the relationships between differences in the number of fiber bundles of the anterior talofibular ligament (ATFL) and differences in the angle of the calcaneofibular ligament (CFL) with respect to the long axis of the fibula and their effects on ankle braking function.

Methods: The study sample included 110 Japanese cadavers. ATFLs were categorized as: Type I with one fiber bundle; Type II with two fiber bundles with incomplete separation and complete separation; and Type III with three fiber bundles. Read More

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http://dx.doi.org/10.1007/s00276-019-02239-2DOI Listing

A computed tomography study of the fibula: morphology, morphometry, intramedullary anatomy, application prospects on intramedullary nailing.

Surg Radiol Anat 2019 Apr 11. Epub 2019 Apr 11.

Centre Hospitalier Universitaire de Limoges Dupuytren, 2 Avenue Martin Luther King, 87000, Limoges, France.

Purpose: The intramedullary percutaneous pinning in fractures of the lateral malleolus is a technique of osteosynthesis that can reduce complications of ORIF. Our study describes the morphology and the morphometry of the fibula, in particular intramedullary, so as to specify the best fibular nail features.

Methods: We conducted a retrospective study on CT acquisitions of fibulae in vivo. Read More

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http://link.springer.com/10.1007/s00276-019-02213-y
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http://dx.doi.org/10.1007/s00276-019-02213-yDOI Listing
April 2019
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Laparoscopic Transcystic Versus Transductal Common Bile Duct Exploration: A Systematic Review and Meta-analysis.

World J Surg 2019 Apr 16. Epub 2019 Apr 16.

Department of General Surgery, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

Objective: To evaluate comparative outcomes of laparoscopic transcystic (TC) and transductal (TD) common bile duct (CBD) exploration.

Methods: We systematically searched MEDLINE, EMBASE, CINAHL, CENTRAL, the World Health Organization International Clinical Trials Registry, ClinicalTrials.gov, ISRCTN Register, and bibliographic reference lists. Read More

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http://dx.doi.org/10.1007/s00268-019-05005-yDOI Listing

The Expression of Key Guidance Genes at a Forebrain Axon Turning Point Is Maintained by Distinct Fgfr Isoforms but a Common Downstream Signal Transduction Mechanism.

eNeuro 2019 Mar-Apr;6(2). Epub 2019 Apr 9.

Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

During development the axons of neurons grow toward and locate their synaptic partners to form functional neural circuits. Axons do so by reading a map of guidance cues expressed by surrounding tissues. Guidance cues are expressed at a precise space and time, but how guidance cue expression is regulated, and in a coordinated manner, is poorly understood. Read More

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http://eneuro.org/lookup/doi/10.1523/ENEURO.0086-19.2019
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http://dx.doi.org/10.1523/ENEURO.0086-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464512PMC
April 2019
1 Read

Practical applications and learning curve for EUS-guided hepaticoenterostomy: results of a large single-center US retrospective analysis.

Endosc Int Open 2019 Apr 12;7(4):E600-E607. Epub 2019 Apr 12.

Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.

 Endoscopic ultrasound-guided hepaticoenterostomy (EUS-HE) is an effective method of endoscopic biliary drainage in cases where endoscopic retrograde cholangiopancreatography has failed or is deemed impossible. Indications for EUS-HE have expanded, resulting in increased interest by endoscopists to learn the procedure; however, few data exist on breadth of application or experience needed to develop proficiency. We describe utilization of EUS-HE for biliary decompression at a large tertiary referral center along with procedural learning curve. Read More

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http://dx.doi.org/10.1055/a-0867-9599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461550PMC

Endovascular Aneurysm Repair by Combining Different Endografts: the Zenith Body and Endurant Limbs.

Vasc Specialist Int 2019 Mar;35(1):10-15

Division of Vascular and Endovascular Surgery, Department of Surgery, College of Medicine, Daegu Catholic University, Daegu, Korea.

Purpose: There are several commercially approved stent grafts in Korea for the treatment of abdominal aortic aneurysms (AAAs). Each device has its advantages and disadvantages based on the patient's anatomy and the clinical situation. The Zenith device allows accurate and precise endograft placement, whereas the Endurant device has improved flexibility and trackability. Read More

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http://www.vsijournal.org/journal/DOIx.php?id=10.5758/vsi.20
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http://dx.doi.org/10.5758/vsi.2019.35.1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453599PMC
March 2019
1 Read

CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors.

Cell Death Discov 2019 11;5:87. Epub 2019 Apr 11.

3Cancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), PO Box 34110, Doha, Qatar.

The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tumor cells. In the current study, we observed that several cancer cell lines, e. Read More

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http://dx.doi.org/10.1038/s41420-019-0169-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459874PMC

Safety and efficacy of cervical disc arthroplasty in preventing the adjacent segment disease: a meta-analysis of mid- to long-term outcomes in prospective, randomized, controlled multicenter studies.

Ther Clin Risk Manag 2019 28;15:531-539. Epub 2019 Mar 28.

Department of Bioengineering, Institute of Biomedical Engineering, Technical University of Wroclaw, Wroclaw, Poland.

Objectives: Cervical disc arthroplasty (CDA) has become an alternative treatment for cervical radiculopathy and myelopathy. This technique preserves appropriate motion at both the index and adjacent disc levels and consequently may prevent adjacent segment degeneration (ASD). The authors performed a meta-analysis to compare the safety and efficacy of CDA to those of the gold standard, anterior cervical discectomy and fusion (ACDF). Read More

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http://dx.doi.org/10.2147/TCRM.S196349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445235PMC
March 2019
1 Read

Immune mechanisms of hypertension.

Nat Rev Immunol 2019 Apr 16. Epub 2019 Apr 16.

Centre for Cardiovascular Biology and Disease Research, Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, Victoria, Australia.

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke. Traditionally, hypertension has been regarded as a disorder of two systems that are involved in the regulation of salt-water balance and cardiovascular function: the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system (SNS). However, current treatments that aim to limit the influence of the RAAS or SNS on blood pressure fail in ~40% of cases, which suggests that other mechanisms must be involved. Read More

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http://dx.doi.org/10.1038/s41577-019-0160-5DOI Listing

Publisher Correction: NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies.

Nat Commun 2019 Apr 16;10(1):1840. Epub 2019 Apr 16.

Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine, Hermann-Rein-Str. 3, 37075, Göttingen, Germany.

Michael W. Sereda was incorrectly associated with the Department of Cellular Neurophysiology, Hanover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany. Read More

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http://dx.doi.org/10.1038/s41467-019-09886-4DOI Listing

India ink: a time-tested histological marker.

Reg Anesth Pain Med 2019 Apr 16. Epub 2019 Apr 16.

Anesthesia, Dalhousie University - Faculty of Health Professions, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1136/rapm-2019-100493DOI Listing

India ink: a time-tested histological marker.

Reg Anesth Pain Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology, CEU San Pablo University School of Medicine, Madrid, Spain.

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http://dx.doi.org/10.1136/rapm-2019-100553DOI Listing

Suprainguinal fascia iliaca block for pediatric hip surgeries.

Reg Anesth Pain Med 2019 Apr 16. Epub 2019 Apr 16.

Anesthesiology and Reanimation, Kocaeli Universitesi Tip Fakultesi, Kocaeli, Turkey.

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http://dx.doi.org/10.1136/rapm-2019-100520DOI Listing

How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.

Learn Mem 2019 May 16;26(5):133-150. Epub 2019 Apr 16.

Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School of the University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

With memory encoding reliant on persistent changes in the properties of synapses, a key question is how can memories be maintained from days to months or a lifetime given molecular turnover? It is likely that positive feedback loops are necessary to persistently maintain the strength of synapses that participate in encoding. Such feedback may occur within signal-transduction cascades and/or the regulation of translation, and it may occur within specific subcellular compartments or within neuronal networks. Not surprisingly, numerous positive feedback loops have been proposed. Read More

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http://dx.doi.org/10.1101/lm.049395.119DOI Listing

BRCA1-No Matter How You Splice It.

Cancer Res 2019 Apr 16. Epub 2019 Apr 16.

The University of Kansas Cancer Center, Kansas City, Kansas.

(breast cancer 1, early onset), a well-known breast cancer susceptibility gene, is a highly alternatively spliced gene. alternative splicing may serve as an alternative regulatory mechanism for the inactivation of the gene in both hereditary and sporadic breast cancers, and other -associated cancers. The alternative transcripts of can mimic known functions, possess unique functions compared with the full-length transcript, and in some cases, appear to function in opposition to full-length In this review, we will summarize the functional "naturally occurring" alternative splicing transcripts of and then discuss the latest next-generation sequencing-based detection methods and techniques to detect alternative splicing patterns and their potential use in cancer diagnosis, prognosis, and therapy. Read More

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-3190DOI Listing
April 2019
1 Read

Varus talar tilt combined with an internal rotation pivot stress assesses the supination instability vector in lateral ankle ligaments' injury - cadaver study.

Foot Ankle Surg 2019 Mar 27. Epub 2019 Mar 27.

Department of Anatomy and Human Embryology, Faculty of Medicine, University of Barcelona, Spain; Department of Orthopaedics, Clinica del Remei, Barcelona, Spain.

Background: The lack of consensus on the relevance of the varus talar tilt test (VTTT) might be due to the divergence between the insufficiency vector of lateral ankle instability and the direction of this clinical test. Our hypothesis is that the VTTT is more accurate to diagnose lateral ankle ligaments rupture when it's applied with a pre-positioning of the foot in internal rotation (IR).

Methods: We compared, in 12 cadaver ankles, the varus opening during a classic VTTT with the same test starting in an IR pivot, using a new arthrometer. Read More

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http://dx.doi.org/10.1016/j.fas.2019.03.007DOI Listing

Oromandibular Dystonia Causing Recurrent Mandibular Open Lock in Two Adolescents Managed with Botulinum Toxin.

J Dent Child (Chic) 2019 Jan;86(1):47-52

Professor, chief and director, Orofacial Pain Program, Department of Oral Health Science, both at the University of Kentucky School of Dentistry, Lexington, KY., USA.

Mandibular open lock is a condition in which the patient is unable to close his/her mouth. This is an uncommon condition in children and adolescents that, when recurrent, can severely affect their quality of life. It can also prove to be a challenge for the clinician. Read More

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January 2019

Establishing a common instantaneous center of rotation for the metatarso-phalangeal and metatarso-sesamoid joints: a theoretical geometric model based on specific morphometrics.

J Orthop Surg Res 2019 Apr 16;14(1):107. Epub 2019 Apr 16.

Center for Statistical Research and Methodology, U.S. Census Bureau, Washington, D.C., USA.

Background: Previous research has identified separate sagittal plane instantaneous centers of rotation for the metatarso-phalangeal and metatarso-sesamoid joints, but surprisingly, it does not appear that any have integrated the distinctive morphological characteristics of all three joints and their respective axes into a model that collectively unifies their functional motions. Since all joint motion is defined by its centers of rotation, establishing this in a complicated multi-dimensional structure such as the metatarso-phalangeal-sesamoid joint complex is fundamental to understanding its functionality and subsequent structural failures such as hallux abducto valgus and hallux rigidus.

Methods: Based on a hypothesis that it is possible to develop an instantaneous center of rotation common to all four osseous structures, specific morphometrics were selected from a sequential series of 0. Read More

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http://dx.doi.org/10.1186/s13018-019-1110-4DOI Listing

A novel approach to neuraxial anesthesia: application of an automated ultrasound spinal landmark identification.

BMC Anesthesiol 2019 Apr 16;19(1):57. Epub 2019 Apr 16.

Department of Women's Anaesthesia, KK Women's and Children's Hospital, Singapore, Singapore.

Background: Neuraxial procedures are commonly performed for therapeutic and diagnostic indications. Currently, they are typically performed via palpation-guided surface landmark. We devised a novel intelligent image processing system that identifies spinal landmarks using ultrasound images. Read More

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http://dx.doi.org/10.1186/s12871-019-0726-6DOI Listing

Safety of EndoAnchors in real-world use: A report from the Manufacturer and User Facility Device Experience database.

Vascular 2019 Apr 16:1708538119844041. Epub 2019 Apr 16.

1 Division of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, KS, USA.

Objectives: A hostile proximal neck anatomy is the most common cause of abdominal aorta endovascular aneurysm repair failure leading to a higher risk of device migration, proximal type I endoleak, and subsequent open surgical repair. Endostapling is a technique to attain better fixation of the endograft to the aortic wall, and the only available device in the USA is Aptus Heli-FX EndoAnchor system (Medtronic Vascular, Santa Rosa, CA, USA). Preliminary data have shown efficacy and safety of its use, and the aim of this study is to assess device-related adverse events in real-world clinical use. Read More

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http://dx.doi.org/10.1177/1708538119844041DOI Listing

Mesenchymal stem cells pretreated with platelet-rich plasma modulate doxorubicin-induced cardiotoxicity.

Hum Exp Toxicol 2019 Apr 16:960327119842613. Epub 2019 Apr 16.

1 Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, Egypt.

The cardiotoxic adverse effect of doxorubicin (DOX) is the major factor limiting its use. Recently, mesenchymal stem cells (MSCs) have been implicated in the preclinical studies of treatment of DOX-induced cardiotoxicity. The question is MSCs pretreated with platelet-rich plasma (PRP) have a better influence on DOX-induced cardiotoxicity compared to the influence of MSCs alone. Read More

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http://journals.sagepub.com/doi/10.1177/0960327119842613
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http://dx.doi.org/10.1177/0960327119842613DOI Listing
April 2019
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Sensitivity of Fine-Needle Aspiration and Imaging Modalities in the Diagnosis of Low-Grade Mucoepidermoid Carcinoma of the Parotid Gland.

Ann Otol Rhinol Laryngol 2019 Apr 16:3489419842582. Epub 2019 Apr 16.

1 Department of Otolaryngology-Head and Neck Surgery, BS, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: To determine the diagnostic accuracy of fine-needle aspiration (FNA) and imaging modalities for low-grade mucoepidermoid carcinoma (MEC) of the parotid gland.

Methods: Retrospective chart review of patients diagnosed with low-grade MEC of the parotid gland following surgical excision between January 2010 and June 2018. Imaging from patients with MEC were randomly mixed with imaging from patients with benign pathology and reviewed in a blinded fashion. Read More

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http://dx.doi.org/10.1177/0003489419842582DOI Listing

[Temporal bone anatomy via transcanal endoscopy].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;54(4):314-320

Department of Otology and Lateral Skull Base Surgery, the First People's Hospital of Foshan, Medical Engineering Research for Hearing and Balance, Foshan 528000, China.

Based on anatomy and clinical operation, this article discussed the anatomical structure of temporal bone and its contiguous relationship under oto-endoscope, through two approaches: the natural external auditory canal and the enlarged external auditory canal. To give an account of the anatomical characteristics of temporal bone under oto-endoscope. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.04.017DOI Listing

Real-Time Measurement of Melanoma Cell-Mediated Human Brain Endothelial Barrier Disruption Using Electric Cell-Substrate Impedance Sensing Technology.

Biosensors (Basel) 2019 Apr 15;9(2). Epub 2019 Apr 15.

Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand.

Electric cell-substrate impedance sensing (ECIS) is an impedance-based method for monitoring changes in cell behaviour in real-time. In this paper, we highlight the importance of ECIS in measuring the kinetics of human melanoma cell invasion across human brain endothelium. ECIS data can be mathematically modelled to assess which component of the endothelial paracellular and basolateral barriers is being affected and when. Read More

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http://dx.doi.org/10.3390/bios9020056DOI Listing

The Accuracy and Cost-Effectiveness of Selective Fetal Echocardiography for the Diagnosis of Congenital Heart Disease in Patients with Pregestational Diabetes Stratified by Hemoglobin A1c.

Am J Perinatol 2019 Apr 16. Epub 2019 Apr 16.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, Ohio.

Objective:  To evaluate the accuracy of antenatal diagnosis of congenital heart disease (CHD) using screening methods including a combination of elevated hemoglobin A1c, detailed anatomy ultrasound, and fetal echocardiography.

Study Design:  This is a retrospective cohort study of all pregnancies complicated by pregestational diabetes from January 2012 to December 2016. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated for each screening regimen. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685490
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http://dx.doi.org/10.1055/s-0039-1685490DOI Listing
April 2019
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Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review.

Eur J Pharm Sci 2019 Apr 13. Epub 2019 Apr 13.

Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, UK. Electronic address:

Oral administration is the most common route of drug delivery. The absorption of a drug from the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of the active pharmaceutical ingredient and its transport across the gut wall. The efficiency of these processes is determined by highly complex and dynamic interplay between the gastrointestinal tract, the dosage form and the API. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.04.013DOI Listing

Challenges associated with the development and transfer of assisted breeding technology in marsupials and monotremes: lessons from the koala, wombat and short-beaked echidna.

Authors:
Stephen Johnston

Reprod Fertil Dev 2019 Apr 17. Epub 2019 Apr 17.

This reflective review describes how a research model, which was originally established for the successful AI of the koala (Phascolarctos cinereus), is currently being developed and extended to the wombat (Lasiorhinus latifrons and Vombatus ursinus) and short-beaked echidna (Tachyglossus aculeatus). The research model centres around the establishment of an AI program and involves: (1) semen collection, evaluation and preservation, requiring an understanding of male reproductive physiology and gamete biology; (2) timing of insemination, based on a knowledge of oestrous cycle and gestation physiology and oestrous behaviour; and (3) the appropriate placement of semen, which relies on an accurate description of female reproductive anatomy. Published and unpublished studies of assisted breeding technology (ABT) development in all three species of Australian mammals reported in this review (koala, wombat and short-beaked echidna) clearly demonstrate the importance of recognising species-specific variation in reproductive biology. Read More

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http://dx.doi.org/10.1071/RD18113DOI Listing

The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy.

Hum Mol Genet 2019 Mar 5. Epub 2019 Mar 5.

MDUK Oxford Neuromuscular Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK.

Duchenne muscular dystrophy (DMD) is a lethal neuromuscular disorder caused by loss of dystrophin. Several therapeutic modalities are currently in clinical trials but none will achieve maximum functional rescue and full disease correction. Therefore, we explored the potential of combining the benefits of dystrophin with increases of utrophin, an autosomal paralogue of dystrophin. Read More

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddz049DOI Listing
March 2019
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Concurrent query processing in a GPU-based database system.

PLoS One 2019 16;14(4):e0214720. Epub 2019 Apr 16.

Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, PA, United States of America.

The unrivaled computing capabilities of modern GPUs meet the demand of processing massive amounts of data seen in many application domains. While traditional HPC systems support applications as standalone entities that occupy entire GPUs, there are GPU-based DBMSs where multiple tasks are meant to be run at the same time in the same device. To that end, system-level resource management mechanisms are needed to fully unleash the computing power of GPUs in large data processing, and there were some researches focusing on it. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214720PLOS
April 2019
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