5,229,909 results match your criteria Anatomy & cell biology[Journal]

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Heightened Exploratory Behavior Following Chronic Excessive Ethanol Drinking: Mediation by Neurotensin Receptor Type 2 in the Anterior Paraventricular Thalamus.

Alcohol Clin Exp Res 2020 Jul 5. Epub 2020 Jul 5.

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, 19129, USA.

Background: Chronic, excessive alcohol drinkers, even without dependence, can exhibit changes in behavior and neurochemical systems. Identifying these changes and their relationship with one another could provide novel avenues for the prevention and treatment of alcohol use disorder. We recently demonstrated, in rats, that neurotensin (NTS) in the paraventricular thalamus (PVT) regulates excessive ethanol drinking. Read More

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http://dx.doi.org/10.1111/acer.14406DOI Listing

A critical evaluation of the material properties and clinical suitability of in-house printed and commercial tooth replicas for endodontic training.

Int Endod J 2020 Jul 4. Epub 2020 Jul 4.

Department of Conservative Dentistry, University Hospital, Julius-Maximilians-University, Würzburg.

Aim: To assess the suitability of several 3D-printed resins for the manufacturing of tooth replicas for endodontic training in comparison with commercially available replicas by analysing the properties of the materials and comparing them with real teeth during endodontic training.

Methodology: Tooth replicas were 3D printed using four resins (NextDent Model, NextDent C&B, V-Print ee, Vero White Plus) and compared with two commercially available products (VDW, Smile Factory) as well as extracted human teeth. Martens hardness, intendation modulus and radiopacity were investigated on these tooth replicas. Read More

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http://dx.doi.org/10.1111/iej.13361DOI Listing

Parkin, an E3 Ubiquitin Ligase, Plays an Essential Role in Mitochondrial Quality Control in Parkinson's Disease.

Cell Mol Neurobiol 2020 Jul 4. Epub 2020 Jul 4.

Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

Parkinson's disease (PD), as one of the complex neurodegenerative disorders, affects millions of aged people. Although the precise pathogenesis remains mostly unknown, a significant number of studies have demonstrated that mitochondrial dysfunction acts as a major role in the pathogeny of PD. Both nuclear and mitochondrial DNA mutations can damage mitochondrial integrity. Read More

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http://dx.doi.org/10.1007/s10571-020-00914-2DOI Listing

The role of MRI pelvimetry in predicting technical difficulty and outcomes of open and minimally invasive total mesorectal excision: a systematic review.

Tech Coloproctol 2020 Jul 4. Epub 2020 Jul 4.

Surgical Outcomes Research Centre (SOuRCe), Sydney, Australia.

Background: The difficulty of performing total mesorectal excision (TME) for rectal cancer partly relies on the surgeon's subjective assessment of the individual patient's pelvic anatomy and tumour characteristics, which generally influences the choice of platform used (open, laparoscopic, robotic or trans-anal surgery). Recent studies have found associations between several anatomical pelvic measurements and surgical difficulty. The aim of this study was to systematically review existing data reporting the use of magnetic resonance imaging (MRI)-based pelvic measurements to predict technical difficulty and outcomes of TME, and determine whether pelvimetry could optimise patient-specific selection of a particular surgical approach. Read More

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http://dx.doi.org/10.1007/s10151-020-02274-xDOI Listing

Towards reconstructing the dipteran demise of an ancient essential gene: E3 ubiquitin ligase Murinedouble minute.

Dev Genes Evol 2020 Jul 4. Epub 2020 Jul 4.

Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI, 48202, USA.

Genome studies have uncovered many examples of essential gene loss, raising the question of how ancient genes transition from essentiality to dispensability. We explored this process for the deeply conserved E3 ubiquitin ligase Murine double minute (Mdm), which is lacking in Drosophila despite the conservation of its main regulatory target, the cellular stress response gene p53. Conducting gene expression and knockdown experiments in the red flour beetle Tribolium castaneum, we found evidence that Mdm has remained essential in insects where it is present. Read More

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http://dx.doi.org/10.1007/s00427-020-00663-8DOI Listing

Bifascicular nature of the flexor digitorum profundus and flexor pollicis longus tendons: forgotten anatomical characteristics rediscovered with US imaging.

Eur Radiol 2020 Jul 4. Epub 2020 Jul 4.

Service d'imagerie médicale, CHU de Toulouse-Purpan, Bâtiment Pierre Paul Riquet,, Place du Dr Baylac, TSA, 40031-31059, Toulouse, France.

Objectives: To demonstrate the bifid configuration of the flexor digitorum profundus (FDP) and flexor pollicis longus (FPL).

Methods: In the first part of this study, 20 digits from 4 cadaver hands were dissected and analyzed using anatomical and histological slices. The second part of the study was carried out over a 12-month period starting in August 2018. Read More

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http://dx.doi.org/10.1007/s00330-020-07048-5DOI Listing

Synaptic Input to Brain Tumors: Clinical Implications.

Neuro Oncol 2020 Jul 5. Epub 2020 Jul 5.

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF, Heidelberg.

The recent discovery of synaptic connections between neurons and brain tumor cells fundamentally challenges our understanding of gliomas and brain metastases, and shows how these tumors can integrate into complex neuronal circuits. Here, we provide an overview on glutamatergic neuron-to-brain tumor synaptic communication (NBTSC) and explore novel therapeutic avenues. First, we summarize current concepts of direct synaptic interactions between presynaptic neurons and postsynaptic glioma cells, and indirect perisynaptic input to metastatic breast cancer cells. Read More

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http://dx.doi.org/10.1093/neuonc/noaa158DOI Listing

Electron Transport Chain Complex II Regulates Steroid Metabolism.

iScience 2020 Jun 20;23(7):101295. Epub 2020 Jun 20.

Department of Chemistry, University of Alberta, Edmonton, Canada.

The first steroidogenic enzyme, cytochrome P450-side-chain-cleavage (SCC), requires electron transport chain (ETC) complexes III and IV to initiate steroid metabolic processes for mammalian survival. ETC complex II, containing succinate dehydrogenase (quinone), acts with the TCA cycle and has no proton pumping capacity. We show that complex II is required for SCC activation through the proton pump, generating an intermediate state for addition of phosphate by succinate. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101295DOI Listing

Association between reduced heart rate variability components and supraventricular tachyarrhythmias in patients with a systemic right ventricle.

Auton Neurosci 2020 Jun 26;227:102696. Epub 2020 Jun 26.

Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Background: Patients with a systemic right ventricle are prone to develop heart failure. Abnormal heart rate variability (HRV), a measure of autonomic dysfunction, is associated with morbidity and mortality in patients with left ventricular failure. The association between HRV and supraventricular arrhythmias (SVTs), which are associated with adverse events in this population, was assessed. Read More

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http://dx.doi.org/10.1016/j.autneu.2020.102696DOI Listing

Patch-based field-of-view matching in multi-modal images for electroporation-based ablations.

Comput Med Imaging Graph 2020 Jun 16;84:101750. Epub 2020 Jun 16.

University of Bordeaux, IMB, UMR CNRS 5251, INRIA Project team Monc, F-33405 Talence Cedex, France; Department of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Various multi-modal imaging sensors are currently involved at different steps of an interventional therapeutic work-flow. Cone beam computed tomography (CBCT), computed tomography (CT) or Magnetic Resonance (MR) images thereby provides complementary functional and/or structural information of the targeted region and organs at risk. Merging this information relies on a correct spatial alignment of the observed anatomy between the acquired images. Read More

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http://dx.doi.org/10.1016/j.compmedimag.2020.101750DOI Listing

Dentate Nucleus as Target for Deep Brain Stimulation in Dystono-Dyskinetic Syndromes.

Neurochirurgie 2020 Jul 2. Epub 2020 Jul 2.

CHRU Montpellier, Service de Neurochirurgie, Montpellier, F-34295, France; IGF, Montpellier, F-34094, France; CNRS UMR5203, Montpellier, F-34094, France; INSERM, U661, Montpellier, F-34094, France; Université Montpellier I, Montpellier, F-34094, France. Electronic address:

Purpose: To discuss the potential of deep brain stimulation (DBS) of the dentate nucleus as a treatment for dystono-dyskinetic syndromes.

Methods: An extensive literature review covered the anatomy and physiology of the dentate nucleus and the experimental evidence for its involvement in the pathophysiology of dystonia and dyskinesia.

Results: Evidence from animal models and from functional imaging in humans is strongly in favor of involvement of the dentate nucleus in dystono-dyskinetic syndromes. Read More

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http://dx.doi.org/10.1016/j.neuchi.2020.04.132DOI Listing

THC and CBD Produce Divergent Effects on Perception and Panic Behaviours via Distinct Cortical Molecular Pathways.

Prog Neuropsychopharmacol Biol Psychiatry 2020 Jul 2:110029. Epub 2020 Jul 2.

Addiction Research Group, University of Western Ontario, London, Ontario, N6A 5C1, Canada; Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, N6A 5C1, Canada; Department of Psychiatry. Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada. Electronic address:

Clinical and pre-clinical evidence demonstrates divergent psychotropic effects of THC vs. CBD. While THC can induce perceptual distortions and anxiogenic effects, CBD displays antipsychotic and anxiolytic properties. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.110029DOI Listing

RAGE modulatory effects on cytokines network and histopathological conditions in malarial mice.

Exp Parasitol 2020 Jul 2:107946. Epub 2020 Jul 2.

Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. Electronic address:

This study was aimed at investigating the involvement of Receptor for Advanced Glycation End Products (RAGE) during malaria infection and the effects of modulating RAGE on the inflammatory cytokines release and histopathological conditions of affected organs in malarial animal model. Plasmodium berghei (P. berghei) ANKA-infected ICR mice were treated with mRAGE/pAb and rmRAGE/Fc Chimera drugs from day 1 to day 4 post infection. Read More

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http://dx.doi.org/10.1016/j.exppara.2020.107946DOI Listing

Treatment of Urinary Incontinence in Patients With Erectile Dysfunction.

Sex Med Rev 2020 Jul 1. Epub 2020 Jul 1.

Professor, Department of Urology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

Introduction: Concurrent urinary incontinence (UI) and erectile dysfunction (ED) can greatly damage a patient's quality of life. Owing to the intertwined anatomy, treatment options for one most certainly have implications on the other.

Objective: The aim of this review is to characterize and elucidate the treatment patients with postprostatectomy UI undergoing concurrent or subsequent treatment of ED. Read More

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http://dx.doi.org/10.1016/j.sxmr.2020.04.006DOI Listing

Fifty years of bisphosphonates: What are their mechanical effects on bone?

Authors:
David B Burr

Bone 2020 Jul 2:115518. Epub 2020 Jul 2.

Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, United States of America; Department of Biomedical Engineering, Indiana University-Purdue University, Indianapolis, Indianapolis, IN 46202, United States of America. Electronic address:

After fifty years of experience with several generations of bisphosphonates (BPs), and 25 years after these drugs were approved for use in humans, their mechanical effects on bone are still not fully understood. Certainly, these drugs have transformed the treatment of osteoporosis in both men and women. There is no question that they do prevent fractures related to low bone mass, and there is widespread agreement that they increase strength and stiffness of the vertebrae. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115518DOI Listing

Anatomic analysis of the attachment of the posteroinferior labrum and capsule to the glenoid: a cadaveric study.

Arthroscopy 2020 Jul 2. Epub 2020 Jul 2.

Department of Orthopedic Surgery, Juntendo University, Tokyo, Japan.

Purpose: To measure the height of the PIGHL attachment to the labrum and the depth of the posteroinferior labrum to the glenoid, macroscopically, and to investigate the morphology of the attachment of the posteroinferior labrum to the glenoid, histologically.

Methods: Fifty cadaveric shoulders without exposed subchondral bone on the glenoid and detached posterior labrum were used. We examined the frequency of the heights of the PIGHL attachments to the labrum and the length of the labral attachment on the glenoid rim at the 7, 8, 9, and 10 o'clock positions, macroscopically. Read More

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http://dx.doi.org/10.1016/j.arthro.2020.06.016DOI Listing

Organoids can be established reliably from cryopreserved biopsy catheter-derived endometrial tissue of infertile women.

Reprod Biomed Online 2020 Apr 29. Epub 2020 Apr 29.

Department of Reproductive Medicine and Gynaecology, University Medical Centre Utrecht, Heidelberglaan 100, CX Utrecht 3584, the Netherlands.

Research Question: Can organoids be established from endometrial tissue of infertile women and does tissue cryopreservation allow for establishment of organoids comparable to organoids derived from freshly biopsied endometrial tissue?

Design: Endometrial tissue was obtained from six infertile women through minimally invasive biopsy using a Pipelle catheter and subjected to organoid development, immediately after biopsy as well as after tissue cryopreservation. Organoid formation efficiency, morphology, expandability potential, endometrial marker expression (immunostaining and reverse transcription quantitative real-time polymerase chain reaction) and hormonal responsiveness (after oestradiol and progesterone treatment) were assessed.

Results: Organoids established from both fresh and frozen tissue at comparable efficiency could be passaged long-term and showed similar morphology, i. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.03.019DOI Listing

The anatomy and function of a bilateral accessory flexor digitorum superficialis muscle: A case report and review of literature.

Morphologie 2020 Jul 1. Epub 2020 Jul 1.

Orthopaedic Biomechanics Laboratory, Congress Medical Foundation, Pasadena, CA, USA.

Anatomical variations of the flexor digitorum superficialis (FDS) include variations of the muscle belly and/or tendon. We present a case of a bilateral accessory FDS muscle and tendon. Dissection was performed in a male specimen (56 years), where an unusual variation was found: a bilateral accessory FDS muscle and tendon. Read More

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http://dx.doi.org/10.1016/j.morpho.2020.06.002DOI Listing

Eyelid and orbital trauma for the primary care physician.

Dis Mon 2020 Jul 1:101045. Epub 2020 Jul 1.

Division of Ophthalmology, NorthShore University Health System, 2050 Pfingsten Rd., Ste. 280, Glenview, IL 60026, United States; Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, United States. Electronic address:

Patients who experience trauma to the eyelid or the orbit may present to their primary care providers or directly to the emergency room for evaluation of their injuries. These patients will often be in pain and may have bleeding around the eye, which can make evaluation of these patients difficult. Many traumatic injuries to the eye require quick and immediate intervention. Read More

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http://dx.doi.org/10.1016/j.disamonth.2020.101045DOI Listing

Management of preseptal and orbital cellulitis for the primary care physician.

Dis Mon 2020 Jul 1:101044. Epub 2020 Jul 1.

Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, United States; Department of Surgery, Northshore University HealthSystem, 2050 Pfingsten Rd., Ste. 280, Glenview, IL 60026, United States. Electronic address:

Preseptal cellulitis and postseptal (orbital) cellulitis represent a spectrum of orbital infections which a primary care provider and ophthalmologist may see during practice. Most often these conditions occur through spread from the sinuses, though there are a variety of other inciting factors. These conditions can both present with erythema and edema, but a complete and thorough exam can help a practitioner differentiate the two. Read More

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http://dx.doi.org/10.1016/j.disamonth.2020.101044DOI Listing

Use of CAD-based pre-bent implants reduces theatre time in orbital floor reconstruction: results of a prospective study.

Br J Oral Maxillofac Surg 2020 Jul 1. Epub 2020 Jul 1.

Department of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address:

In this prospective study we evaluated the duration of insertion and the accuracy of fitting of computer-aided design (CAD)-based pre-bent orbital floor plates compared with non-preformed orbital plates in reconstruction of the orbital floor. Thirty-six patients with unilateral fractures of the orbital floor were included; pre-bent plates were used in 25 and non-preformed plates in 11. Preoperative computed tomography (CT) scans were used for CAD of individualised implants. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.11.020DOI Listing

Transcription factor MafB in podocytes protects against the development of focal segmental glomerulosclerosis.

Kidney Int 2020 Apr 28. Epub 2020 Apr 28.

Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, Japan; Life Science Center of Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Ibaraki, Japan. Electronic address:

Focal segmental glomerulosclerosis (FSGS) is a common cause of steroid-resistant nephrotic syndrome. Spontaneous remission of FSGS is rare and steroid-resistant FSGS frequently progresses to renal failure. Many inheritable forms of FSGS have been described, caused by mutations in proteins that are important for podocyte function. Read More

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http://dx.doi.org/10.1016/j.kint.2020.02.038DOI Listing

Thyroidectomy induces thyroglobulin formation by parotid salivary glands in rats.

Acta Histochem 2020 Jul 26;122(5):151568. Epub 2020 May 26.

Oral Biology Department, Faculty of Dentistry, Tanta University, Tanta, Egypt.

Structural changes in parotid gland (PG) were previously reported following ablation of thyroid gland. However, the functional alterations (especially for proteins) have not been elucidated yet. Herein, we investigated the effect of rat thyroidectomy on PG structure and protein content and studied the ability of thyroxin-supplementation to alleviate the associated structural and functional changes. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151568DOI Listing

Effects of adipose- derived stromal vascular fraction on asherman syndrome model.

Acta Histochem 2020 Jul 20;122(5):151556. Epub 2020 May 20.

Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Asherman's syndrome (AS) is an endometrial damage that results in infertility in women. Although stem cell therapy has been introduced as a potential treatment for this syndrome, its use in clinical settings remains challenging because of the likelihood of contamination and cell differentiation. Herein, we investigated the effects of adipose-derived stromal vascular fraction (SVF) transplantation on proliferation and angiogenesis in the endometrium in an AS model. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151556DOI Listing

Three-dimensional co-culture of human spermatogonial stem cells with Sertoli cells in soft agar culture system supplemented by growth factors and Laminin.

Acta Histochem 2020 Jul 13;122(5):151572. Epub 2020 Jun 13.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Application of a three-dimensional (3D) culture system for in vitro proliferation and differentiation of human spermatogonial stem cells (SSCs) is a useful tool for the investigation of the spermatogenesis process and the management of male infertility particularly in prepubertal cancer patients. The main purpose of this study was to investigate the proliferation of human SSCs co-cultured with Sertoli cells in soft agar culture system (SACS) supplemented by Laminin and growth factors. Testicular cells were isolated from testes of brain-dead patients and cultured in two-dimensional (2D) culture system for 3 weeks. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151572DOI Listing

Ectopic subcutaneous transplantation of fetal rat urogenital sinus and seminal vesicle promotes the organ growth and formation.

Acta Histochem 2020 Jul 10;122(5):151569. Epub 2020 Jun 10.

Division of Microscopic and Developmental Anatomy, Department of Anatomy, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Purpose: The fate of subcutaneously transplanted urogenital sinus (UGS) and seminal vesicle (SV) was investigated in the present study.

Materials And Methods: Fetal UGS and SV extracted from 20-embryonic-day-old male normal and GFP transgenic rats were subcutaneously transplanted into 7-week-old male immunologically inhibited rats. The transplants were then examined at 2, 4, 8, and 16 weeks after transplantation. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151569DOI Listing

Integration of tumour infiltrating lymphocytes, programmed cell-death ligand-1, CD8 and FOXP3 in prognostic models for triple-negative breast cancer: Analysis of 244 stage I-III patients treated with standard therapy.

Eur J Cancer 2020 Jul 1;136:7-15. Epub 2020 Jul 1.

Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Medical Oncology 2, Istituto Oncologico Veneto IOV - IRCCS, Padova, Italy.

Background: Tumour infiltrating lymphocytes (TILs) are an established prognostic biomarker for triple-negative breast cancer (TNBC). We evaluated the role of programmed cell-death ligand-1 (PD-L1), CD8 and FOXP3 expression in refining a prognostic model for non-metastatic TNBC beyond classic factors and TILs.

Methods: Primary tumour samples from 244 early patients with TNBC, all treated with surgery and chemotherapy, were collected. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.05.014DOI Listing

Questioning the prognostic role of BAP-1 immunohistochemistry in malignant pleural mesothelioma: A single center experience with systematic review and meta-analysis.

Lung Cancer 2020 Jun 21;146:318-326. Epub 2020 Jun 21.

Clinical Oncology, Università Politecnica delle Marche, AOU Ospedali Riuniti, Via Conca 71, 60126, Ancona, Italy. Electronic address:

Introduction: The prognostic role of BRCA1 associated protein-1 (BAP1) expression in malignant pleural mesothelioma (MPM) is a matter of debate. We aimed to clarify whether MPM patients with loss of BAP1 expression have better overall survival (OS) compared to BAP1 positive patients.

Methods: BAP1 immunohistochemical staining of tumor samples from 60 MPM patients treated at our institution with first-line chemotherapy was evaluated. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.024DOI Listing

Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution.

iScience 2020 Jun 20;23(7):101290. Epub 2020 Jun 20.

German Center for Neurodegenerative Diseases (DZNE), Munich 81377, Germany; Munich Cluster of Systems Neurology (SyNergy), Munich 81377, Germany. Electronic address:

Volume electron microscopy enables the ultrastructural analysis of biological tissue. Currently, the techniques involving ultramicrotomy (ATUM, ssTEM) allow large fields of view but afford only limited z-resolution, whereas ion beam-milling approaches (FIB-SEM) yield isotropic voxels but are restricted in volume size. Now we present a hybrid method, named ATUM-FIB, which combines the advantages of both approaches. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101290DOI Listing

Prediction of inter-fractional radiotherapy dose plans with domain translation in spatiotemporal embeddings.

Med Image Anal 2020 May 17;64:101728. Epub 2020 May 17.

Polytechnique Montréal, Montréal, Québec, Canada; CHUM Research Center, Montréal, Québec, Canada. Electronic address:

External beam radiation therapy fractions have become extremely complex and tedious procedures to plan, due to stringent requirements of delivering the highest radiation dose to the tumor while maximally avoiding organs at risk. However, due to anatomic and/or biological changes between fractions, dose re-optimization may be needed. Re-optimization is a time-consuming task which is typically triggered based on subjective visual assessment by an experienced physician. Read More

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http://dx.doi.org/10.1016/j.media.2020.101728DOI Listing

SURGICAL PLANNING with PATIENT-SPECIFIC THREE-DIMENSIONAL PRINTED PANCREATICOBILIER DISEASE MODELS - Cross-Sectional Study.

Int J Surg 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiology.

Background: Three-dimensional (3D) printing has been increasingly used in medical applications with the creation of accurate patient-specific 3D printed models in medical imaging data. This study has been planned based on the fact that research on 3D printing in pancreaticobiliary disease is limited due to lack of studies on validation of model accuracy.

Methods: This is an innovative study where general surgery residents are presented 5 distinct hepatopancreatobiliary disease scenarios to generate a perception and required to compare their perception level of these cases with magnetic resonance cholangiopancreatography (MRCP), 3D images and 1:1 solid models that the pathology, diverse diagnosis and presurgery diagnosis stages can be observed. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.06.017DOI Listing

Castleman's disease in two patients with spondyloarthritis treated by Tumor Necrosis Factor-alpha antagonists.

Joint Bone Spine 2020 Jul 1. Epub 2020 Jul 1.

Department of Rheumatology, CIC/CRB 1404, Rouen University Hospital, Normandie Univ, UNIROUEN, F 76000 Rouen, France. Electronic address:

Castleman's disease is a rare lymphoproliferative syndrome involving several anatomical and clinical entities. We report two cases of Castleman's disease in patients with spondyloarthritis (with and without psoriasis) treated with Tumor Necrosis Factor-alpha blockers. During follow-up, imaging examinations, carried out for disease assessment, fortuitously revealed a pelvic mass close to the psoas or an atypical cervical adenopathy. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.06.012DOI Listing

Phosphatidylserine nanoliposomes inhibit glucocorticoid-induced osteoporosis: A potential combination therapy with alendronate.

Life Sci 2020 Jul 1:118033. Epub 2020 Jul 1.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

The present study purposes to investigate the effects of phosphatidylserine liposomes (PSLs) and phosphatidylserine liposomes containing alendronate (AL-PSLs) on the improvement of methylprednisolone (MP) induced osteoporosis in a rat model. AL-PSLs formulation was prepared, characterized, and evaluated in different pH media to simulate gastrointestinal condition. Osteoporosis was induced by 3 weeks oral administration of methylprednisolone (10 mg/kg) and then treatment by PSLs, AL-PSLs, and alendronate (AL). Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118033DOI Listing

Long-term Labeling of Microelectrode Tracks with Fluorescent Latex Microspheres.

J Neurosci Methods 2020 Jul 1:108839. Epub 2020 Jul 1.

Department of Ophthalmology, Program in Neuroscience, University of California, San Francisco, CA, 94143, USA. Electronic address:

Background: After physiological recordings are performed in behaving animals, it is valuable to identify microelectrode tracks in histological sections so that neuronal responses can be correlated with brain anatomy. However, no good method currently exists for long-term labeling, so that microelectrode tracks can be recovered months or even years after recording sessions.

New Method: Penetrations were made into the brains of mice with microelectrodes coated with fluorescent dyes packaged into 0. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2020.108839DOI Listing

Association of Infra-Patellar Fat Pad Size with Age and Body Weight in Children and Adolescents.

Ann Anat 2020 Jul 1:151533. Epub 2020 Jul 1.

Department of Imaging and Functional Musculoskeletal Research, Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Department of Orthopedic Surgery & Traumatology, Landesklinik Tamsweg, Paracelsus Medical University, Tamsweg, Austria.

Background: The infra-patellar fat pad (IPFP) represents a potential mediator between obesity, low grade inflammation, and knee osteoarthritis via endocrine pathways. Yet, not only in adults, but also in childhood obesity negatively impacts knee structures.

Objective: The current study therefore investigated the sex-specific growth of the IPFP with age and body weight in healthy children and adolescents. Read More

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http://dx.doi.org/10.1016/j.aanat.2020.151533DOI Listing

Is the Die Cast by Surgeon's Choice or Patient's Anatomy? Late Outcomes in Tetralogy of Fallot.

Can J Cardiol 2020 Apr 1. Epub 2020 Apr 1.

University of Texas Southwestern, Children's Health Dallas, Dallas, Texas, USA.

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http://dx.doi.org/10.1016/j.cjca.2020.03.039DOI Listing

Using Deep Learning to Predict Beam-Tunable Pareto Optimal Dose Distribution for Intensity Modulated Radiation Therapy.

Med Phys 2020 Jul 4. Epub 2020 Jul 4.

Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

Purpose: Many researchers have developed deep learning models for predicting clinical dose distributions and Pareto optimal dose distributions. Models for predicting Pareto optimal dose distributions have generated optimal plans in real time using anatomical structures and static beam orientations. However, Pareto optimal dose prediction for Intensity Modulated Radiation Therapy (IMRT) prostate planning with variable beam numbers and orientations has not yet been investigated. Read More

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http://dx.doi.org/10.1002/mp.14374DOI Listing

Effect of fullerene nanoemulsion on the repair of wrinkles induced by UVB radiation: A c57bl6 mice model.

Skin Res Technol 2020 Jul 4. Epub 2020 Jul 4.

Department of Pathology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

Introduction: The effect of fullerene nanoemulsion on skin wrinkle repair in an animal model was evaluated using ultrasonic images processing.

Methods: Wrinkles were created in C57BL6 mice during 35 days of UVB radiation. Then, to investigate the therapeutic effect of fullerene nanoemulsions, mice were divided into three groups of control, UVB radiation, and treatment with fullerene nanoemulsion. Read More

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http://dx.doi.org/10.1111/srt.12903DOI Listing

Morphometric characteristics of myocardial sleeves of the pulmonary veins.

J Cardiovasc Electrophysiol 2020 Jul 4. Epub 2020 Jul 4.

HEART - Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland.

Background: The pulmonary veins are covered by a myocardial layer, which is often an electrical substrate for atrial fibrillation. The aim of this study was to study the morphologic characteristics of the myocardial sleeves of pulmonary veins by examining a large group of freshly autopsied human material.

Methods And Results: The study macroscopically examined a total of 498 pulmonary veins draining the left atrium (120 unpreserved human hearts). Read More

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http://dx.doi.org/10.1111/jce.14651DOI Listing

Epigenetic Restoration of Voltage-gated Potassium Channel Kv1.2 Alleviates Nerve Injury-induced Neuropathic Pain.

J Neurochem 2020 Jul 3. Epub 2020 Jul 3.

Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.

Voltage-gated potassium channels (Kv) are important regulators of neuronal excitability for its role of regulating resting membrane potential and repolarization. Recent studies show that Kv channels participate in neuropathic pain, but the detailed underlying mechanisms are far from being clear. In the current study, we used siRNA, miR-137 agomir and antagomir to regulate the expression of Kv1. Read More

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http://dx.doi.org/10.1111/jnc.15117DOI Listing

Switching Diseased Cells from Cytosolic Aerobic Glycolysis to Mitochondrial Oxidative Phosphorylation: A Metabolic Rhythm Regulated by Melatonin?

J Pineal Res 2020 Jul 3:e12677. Epub 2020 Jul 3.

Department of Cell Systems and Anatomy, UT Health Science Center at San Antonio, San Antonio, Texas, USA.

This commentary reviews the concept of the circadian melatonin rhythm playing an essential role in reducing the development of diseases such as solid tumors which adopt cytosolic aerobic glycolysis (Warburg effect) to support their enhanced metabolism. Experimental data shows that solid mammary tumors depend on aerobic glycolysis during the day but likely revert to mitochondrial oxidative phosphorylation at night for ATP production. This conversion of diseased cells during the day to a healthier phenotype at night occurs under control of the circulating melatonin rhythm. Read More

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http://dx.doi.org/10.1111/jpi.12677DOI Listing

Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study.

Arch Osteoporos 2020 Jul 3;15(1):100. Epub 2020 Jul 3.

Department of Preventive Medicine, Ajou University School of Medicine, 206 Worldcup-ro, Yeongtong-gu, Suwon, 443-721, South Korea.

The bone mineral densities (BMDs) of the femoral neck and total hip, and the lumbar spine trabecular bone score (TBS), tended to decrease with age in both men and women, whereas the lumbar spine BMD tended to increase. Lumbar spine BMD is thus inappropriate for evaluating longitudinal changes in bone loss; the lumbar spine TBS is an alternative measure.

Purpose: Aging is associated with a decrease in bone mass and quality. Read More

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http://dx.doi.org/10.1007/s11657-020-00731-6DOI Listing

The Modulatory Effect of Metformin on Ethanol-Induced Anxiety, Redox Imbalance, and Extracellular Matrix Levels in the Brains of Wistar Rats.

J Mol Neurosci 2020 Jul 3. Epub 2020 Jul 3.

Department of Neuroscience - Psychiatry, Iuliu Hatieganu University of Medicine and Pharmacy, 43 Victor Babes Street, Cluj-Napoca, Romania.

The study investigated the potential neuroprotective effects of metformin (MET) on alcohol-induced neurotoxicity in adult Wistar rats. The animals were randomized in four groups (n = 10): control, alcohol (ALC), ALC + MET, and MET. ALC (2 g/kg b. Read More

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http://dx.doi.org/10.1007/s12031-020-01593-wDOI Listing

Rapid progression to end-stage renal disease in a child with IgA-dominant infection-related glomerulonephritis associated with parvovirus B19.

CEN Case Rep 2020 Jul 3. Epub 2020 Jul 3.

Department of Pediatric Nephrology, School of Medicine, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Parvovirus B19 (PVB19) has been known to cause acute glomerulonephritis and nephrotic syndrome with various renal histologic patterns, such as endocapillary glomerulonephritis and collapsing glomerulopathy. Remission is achieved spontaneously or by treatment with steroid and/or immunosuppressants in most patients, except those with sickle cell anemia or two APOL1 risk alleles. In this study, we report the case of a previously healthy 5-year-old boy with infection-related glomerulonephritis (IRGN) associated with PVB19 that progressed to end-stage renal disease (ESRD). Read More

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http://dx.doi.org/10.1007/s13730-020-00501-wDOI Listing

Endocrine Dysfunction Following Stroke.

J Neuroimmune Pharmacol 2020 Jul 3. Epub 2020 Jul 3.

Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT, 05405-0068, USA.

Endocrine dysfunction is known to occur after traumatic brain injury. The purpose of this study was to examine the incidence of various endocrine dysfunctions after a stroke. The Taiwan National Health Insurance Research Database (NHIRD) was searched from 2001 to 2011 for patients with a diagnosis of stroke. Read More

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http://dx.doi.org/10.1007/s11481-020-09935-6DOI Listing

Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders.

Nat Commun 2020 Jul 3;11(1):3358. Epub 2020 Jul 3.

Developmental Neurogenomics Unit, National Institute of Mental Health, Bethesda, MD, USA.

Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain anatomy. However, it is unclear how genetic risks for neurodevelopmental disorders are translated into spatially patterned brain vulnerabilities. Here, we integrated cortical neuroimaging data from patients with neurodevelopmental disorders caused by genomic copy number variations (CNVs) and gene expression data from healthy subjects. Read More

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http://dx.doi.org/10.1038/s41467-020-17051-5DOI Listing

Prolonged avoidance training exacerbates OCD-like behaviors in a rodent model.

Transl Psychiatry 2020 Jul 3;10(1):212. Epub 2020 Jul 3.

Departments of Psychiatry and Anatomy & Neurobiology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, 00936, USA.

Obsessive-compulsive disorder (OCD) is characterized by compulsive behaviors that often resemble avoidance of perceived danger. OCD can be treated with exposure-with-response prevention (ERP) therapy in which patients are exposed to triggers but are encouraged to refrain from compulsions, to extinguish compulsive responses. The compulsions of OCD are strengthened by many repeated exposures to triggers, but little is known about the effects of extended repetition of avoidance behaviors on extinction. Read More

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http://dx.doi.org/10.1038/s41398-020-00892-5DOI Listing

The morphometric analysis of the male cadaveric native knees of the ethnic igbos of South East Nigeria and its implication in total knee replacement.

Niger J Clin Pract 2020 Jul;23(7):1013-1021

Department of Anatomy, University of Nigeria, Enugu Campus, Enugu, Nigeria.

Background: In spite of its consideration as a very successful procedure nearly all total knee replacement (TKR) prostheses were designed based on the parameters of male 4,Western, and primarily white native knees. Mismatch between prosthesis and bone surface or malposition can lead to poor outcome of TKR.

Aim: To determine the parameters of the native knee of the ethnic Igbos of South East Nigeria, determine any correlations amongst them ,compare the values with that of other populations and discuss its implication in total knee replacement. Read More

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http://dx.doi.org/10.4103/njcp.njcp_700_19DOI Listing

Institutionalized Youth and the Anatomy Lab in Twentieth Century Michigan.

Pediatrics 2020 Jul 3. Epub 2020 Jul 3.

Departments of Internal Medicine and History, Medical School, University of Michigan, Ann Arbor, Michigan

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http://dx.doi.org/10.1542/peds.2019-2748DOI Listing

Novel Prognostic Factor for Uveal Melanoma: Bioinformatics Analysis of Three Independent Cohorts.

Anticancer Res 2020 Jul;40(7):3839-3846

Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea

Background/aim: Because 50% of uveal melanoma metastasize within 10 years of diagnosis, there is urgent need for accurate prognostic factors.

Materials And Methods: To identify genes that can act as prognostic factors in uveal melanoma, we performed survival analyses using three independent cohorts. Using log-rank test and univariate cox regression, genes which could stratify the prognosis in all cohorts simultaneously depending on their expression levels were selected as novel biomarkers. Read More

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http://dx.doi.org/10.21873/anticanres.14373DOI Listing
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