160,059 results match your criteria Anatomical record Hoboken N.J. : 2007[Journal]


The Relationship of Transepicondylar Width with the Distal and Posterior Femoral Condyles and Its Clinical Implications: A Three-Dimensional Study.

J Knee Surg 2020 Jul 6. Epub 2020 Jul 6.

Department of Orthopaedic Surgery, National Orthopaedic Center of Excellence for Research and Learning (NOCERAL), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background:  Restoration of the anatomical joint line, while important for clinical outcomes, is difficult to achieve in revision total knee arthroplasty (rTKA) due to distal femoral bone loss. The objective of this study was to determine a reliable method of restoring the anatomical joint line and posterior condylar offset in the setting of rTKA based on three-dimensional (3D) reconstruction of computed tomography (CT) images of the distal femur.

Methods:  CT scans of 50 lower limbs were analyzed. Read More

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http://dx.doi.org/10.1055/s-0040-1713733DOI Listing

Two Hundred Twenty-Six Consecutive Deep Brain Stimulation Electrodes Placed Using an "Asleep" Technique and the Neuro|MateTM Robot for the Treatment of Movement Disorders.

Oper Neurosurg (Hagerstown) 2020 Jul 6. Epub 2020 Jul 6.

Functional Neurosurgery Group, Clinical Neurosciences, University of Bristol, Bristol, United Kingdom.

Background: Robotics in neurosurgery has demonstrated widening indications and rapid growth in recent years. Robotic precision and reproducibility are especially pertinent to the field of functional neurosurgery. Deep brain stimulation (DBS) requires accurate placement of electrodes in order to maximize efficacy and minimize side effects. Read More

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http://dx.doi.org/10.1093/ons/opaa176DOI Listing

A systematic review on the association between obstructive sleep apnea and chronic kidney disease.

Sleep Med Rev 2020 May 18;53:101337. Epub 2020 May 18.

Department of Clinical, Internal, Anesthetic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

This systematic review aims to provide a more comprehensive overview of the association between obstructive sleep apnea (OSA) and chronic kidney disease (CKD). A PubMed search was conducted using the terms "(obstructive sleep disorders OR obstructive sleep apnea OR obstructive sleep apnea syndrome) AND (kidney function OR renal outcome OR chronic kidney disease OR end stage renal disease)". Four hundred seventy four articles were initially retrieved, 227 in the last five years. Read More

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http://dx.doi.org/10.1016/j.smrv.2020.101337DOI Listing

Knowledge-based assessment of focal dose escalation treatment plans in prostate cancer.

Int J Radiat Oncol Biol Phys 2020 Jul 3. Epub 2020 Jul 3.

Netherlands Cancer Institute, Radiation Oncology, Amsterdam, The Netherlands.

Purpose: In a randomized focal dose escalation radiotherapy trial for prostate cancer ([X]), up to 95 Gy was prescribed to the tumor in the dose-escalated arm, with 77 Gy to the entire prostate in both arms. As dose constraints to organs at risk (OARs) had priority over dose escalation and suboptimal planning could occur, we investigated how well the dose to the tumor was boosted. We developed an anatomy-based prediction model to identify plans with suboptimal tumor dose, and performed replanning to validate our model. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.06.072DOI Listing

Metformin loaded cholesterol-lysine conjugate nanoparticles: a novel approach for protecting HDFs against UVB-induced senescence.

Int J Pharm 2020 Jul 3:119603. Epub 2020 Jul 3.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Cellular senescence is one of the hallmarks of aging. Since senescence of dermal fibroblasts has been reported in vivo, reduction of the deleterious effects of these cells, has been considered an important intervention to counteract skin aging. Promising anti-aging effect of metformin has been reported. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119603DOI Listing

The roles of MicroRNAs in neural regenerative medicine.

Authors:
Xin Tang Cheng Sun

Exp Neurol 2020 Jul 3:113394. Epub 2020 Jul 3.

Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Co-innovation Center of Neuroregenetation, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, China. Electronic address:

MicroRNAs (miRNAs) are an abundant class of small non coding regulatory RNAs that operate as prominent modulators of mammalian gene expression. It is now well established that post-transcriptional regulation of gene expression plays a vital role in both physiological and pathological processes such as neural development and neural regeneration. The flexibility and efficiency of miRNA function provide precise temporal and spatial gene regulatory capacities that are essential for proper maintenance of neural circuits. Read More

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http://dx.doi.org/10.1016/j.expneurol.2020.113394DOI Listing

COVID-19 and anatomy: Stimulus and initial response.

J Anat 2020 Jul 6. Epub 2020 Jul 6.

Centre for Anatomy and Human Identification, School of Science and Engineering, University of Dundee, Dundee, UK.

The outbreak of COVID-19, resulting from widespread transmission of the SARS-CoV-2 virus, represents one of the foremost current challenges to societies across the globe, with few areas of life remaining untouched. Here, we detail the immediate impact that COVID-19 has had on the teaching and practice of anatomy, providing specific examples of the varied responses from several UK, Irish and German universities and medical schools. Alongside significant issues for, and suspension of, body donation programmes, the widespread closure of university campuses has led to challenges in delivering anatomy education via online methods, a particular problem for a practical, experience-based subject such as anatomy. Read More

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http://dx.doi.org/10.1111/joa.13274DOI Listing

Anatomical and histological study of the alar fascia.

Clin Anat 2020 Jul 6. Epub 2020 Jul 6.

Department of Anatomical Sciences, St. George's University, Grenada, West Indies.

Introduction: The alar fascia remains one of the most variably described fascial structure in the human body. Much disagreement persists in the literature and mainstream anatomical texts about its anatomy, function, and clinical significance. It is generally described as a coronally-oriented fascial sheet separating the retropharyngeal space anteriorly from the danger space posteriorly. Read More

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http://dx.doi.org/10.1002/ca.23644DOI Listing

Macromolecular proton fraction mapping based on spin-lock magnetic resonance imaging.

Magn Reson Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong SAR, China.

Purpose: In MRI, the macromolecular proton fraction (MPF) is a key parameter of magnetization transfer (MT). It represents the relative amount of immobile protons associated with semi-solid macromolecules involved in MT with free water protons. We aim to quantify MPF based on spin-lock MRI and explore its advantages over the existing MPF-mapping methods. Read More

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http://dx.doi.org/10.1002/mrm.28362DOI Listing

Three-dimensional measurement of the course of the radial nerve at the posterior humeral shaft: An in vivo anatomical study.

J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(2):2309499020930828

Department of Orthopaedic Surgery, School of Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Purpose: Iatrogenic radial nerve injury caused by surgical exposure of the humerus is a serious complication. We aimed to describe the course of the radial nerve at the posterior humeral shaft using a three-dimensional (3D) reconstruction technique by utilizing computed tomography (CT) images of living subjects. We hypothesized that the course of the radial nerve in the posterior aspect of the humeral shaft would be reliably established using this technique and the measurements would have satisfactory intraobserver/interobserver reliabilities. Read More

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http://dx.doi.org/10.1177/2309499020930828DOI Listing

Computed Tomography Image Analysis and Clinical Correlations of Retromaxillary Cells.

Ear Nose Throat J 2020 Jul 5:145561320936963. Epub 2020 Jul 5.

Department of Otolaryngology-Head and Neck Surgery, Wuhan University, Renmin Hospital, Wuhan, Hubei Province, People's Republic of China.

Objective: This study aimed to investigate and analyze the anatomic characteristics of the retromaxillary cell (RMC) by using computed tomography (CT) images of paranasal sinuses and to improve its identification with ethmomaxillary sinus (EMS).

Methods: The paranasal sinus CT scans of 441 outpatients or inpatients in our hospital from January 2018 to October 2018 were analyzed. The incidence of RMC, EMS, Haller cell, imaging anatomical characteristics, and morphological manifestations were observed via sinus CTs. Read More

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http://dx.doi.org/10.1177/0145561320936963DOI Listing

Orbital anatomical parameters affecting outcome of deep lateral orbital wall decompression.

Eur J Ophthalmol 2020 Jul 6:1120672120941433. Epub 2020 Jul 6.

Division of Orbital and Ophthalmic Plastic Surgery, Jules Stein Eye Institute, University of California-Los Angeles, Los Angeles, CA, USA.

Purpose: To determine orbital anatomical parameters that affect surgical outcome of deep lateral orbital wall decompression.

Methods: Twenty orbits of 20 patients with moderate proptosis (maximum 25 mm) due to thyroid eye disease who were stable for at least 6 months were included in this prospective cohort study. Four parameters including lateral orbital wall distance (LOWD), removable surface area (RSA), removable surface length (RSL), and sphenoid door jamb thickness (SDJ) were evaluated by computed tomography (CT) scan prior to surgery in these patients. Read More

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http://dx.doi.org/10.1177/1120672120941433DOI Listing

Comparative assessment of the efficiency of various decellularization agents for bone tissue engineering.

J Biomed Mater Res B Appl Biomater 2020 Jul 5. Epub 2020 Jul 5.

Department of Anatomical Sciences, School of Medicine, Laboratory for Stem Cell Research, Shiraz University of Medical Sciences, Shiraz, Iran.

Bone regeneration can be possible through grafts or engineered bone replacement when bone defects are larger than the critical size. Decellularized bone extracellular matrix (ECM) is an alternative that is able to accelerate tissue regeneration, while decellularization protocols influence engineered bone quality. The objective of this study was to compare the quality of decellularized bone produced through different methods. Read More

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http://dx.doi.org/10.1002/jbm.b.34677DOI Listing

Congenital left ventricular diverticulum repair in an adult with dual patch technique.

J Card Surg 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, The Mount Sinai Hospital, New York, New York.

Rupture of a congenital left ventricular diverticulum (CLVD), a rare anatomical anomaly, is a catastrophic event, with potential fatal consequences. Repair techniques documented in the literature include primary closure and single patch closure. We describe a case of a 57-year-old woman with symptomatic anterolateral CLVD. Read More

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http://dx.doi.org/10.1111/jocs.14752DOI Listing

Asymptomatic Presacral Paraganglioma: Management of an Unpredictable Intraoperative Finding.

Surg J (N Y) 2020 Apr 30;6(2):e131-e134. Epub 2020 Jun 30.

Department of Surgery, University Hospital of Larissa, Larissa, Greece.

Paragangliomas are rare neuroendocrine tumors originating from the embryological neural crest. We report a rare case of a patient with an asymptomatic presacral mass (incidentaloma) who experienced an unpredictable intraoperative hypertensive crisis after manipulation of the tumor. Presacral neoplasms pose a diagnostic and therapeutic challenge due to their obscure anatomical location and the difficulty in performing an R0 excision. Read More

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http://dx.doi.org/10.1055/s-0040-1712545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326578PMC

Case Report: Virtual and Interactive 3D Vascular Reconstruction Before Planned Pancreatic Head Resection and Complex Vascular Anatomy: A Bench-To-Bedside Transfer of New Visualization Techniques in Pancreatic Surgery.

Front Surg 2020 18;7:38. Epub 2020 Jun 18.

University Hospital for Visceral Surgery, Pius-Hospital, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Bühler's anastomosis (or Bühler's arcade) is an embryonic relic and represents an arterio-arterial connection between the superior mesenteric artery and the celiac trunk. It can be found as a variety in 1-2% of patients. We present a case of a patient with metatastatic squamous cell carcinoma of the lung. Read More

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http://dx.doi.org/10.3389/fsurg.2020.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314924PMC

Toward Generating Subtype-Specific Mesencephalic Dopaminergic Neurons .

Front Cell Dev Biol 2020 17;8:443. Epub 2020 Jun 17.

Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada.

Mesencephalic dopaminergic (mDA) neurons derived from pluripotent stem cells (PSCs) have proven to be pivotal for disease modeling studies and as a source of transplantable tissue for regenerative therapies in Parkinson's disease (PD). Current differentiation protocols can generate standardized and reproducible cell products of dopaminergic neurons that elicit the characteristic transcriptional profile of ventral midbrain. Nonetheless, dopamine neurons residing in the mesencephalon comprise distinct groups of cells within diffusely defined anatomical boundaries and with distinct functional, electrophysiological, and molecular properties. Read More

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http://dx.doi.org/10.3389/fcell.2020.00443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311634PMC

Evaluation of a Novel 3D-Printed Urinary Catheterization Simulation Model in Undergraduate Medical Teaching.

Cureus 2020 May 31;12(5):e8377. Epub 2020 May 31.

Urology, Memorial University of Newfoundland and Labrador, St. John's, CAN.

Introduction Urinary catheter insertion is a mandatory procedure taught during medical school. It is imperative that learners are provided the opportunity to practice the procedure, as an improper catheterization technique can result in urethral trauma and contribute to urinary tract infections. Simulation training offers the advantage of avoiding patient harm while allowing learners to feel comfortable to learn from their mistakes, resulting in increased user confidenceand shortening the learning curve for basic procedures. Read More

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http://dx.doi.org/10.7759/cureus.8377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328704PMC

Optical coherence tomography angiography using the black-and-white pixel binarization histogram software: a new technique for evaluating healing of macular holes in two surgical techniques.

Int J Retina Vitreous 2020 1;6:25. Epub 2020 Jul 1.

Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

Background: Many factors can influence the functional outcomes of macular hole surgery and some studies have tried to describe anatomical features that could predict successful treatment. The purpose of this study is to describe a new technique for evaluating the healing of macular holes after two surgical techniques using a black-and-white pixel binarization histogram software by optical coherence tomography angiography and its potential functional implications.

Methods: This was a retrospective, observational case series of patients who presented with idiopathic full-thickness macular holes and underwent vitreoretinal surgery for successful macular hole closure using the internal limiting membrane peeling technique or the inverted peeling technique or the free internal limiting membrane flap technique. Read More

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http://dx.doi.org/10.1186/s40942-020-00229-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329410PMC

Simultaneous resection of abdominal aortic aneurysm and left renal cell carcinoma: A rare case and review of the literature.

J Cardiovasc Thorac Res 2020 7;12(2):152-155. Epub 2020 Jan 7.

Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA.

We report a rare case of concomitant abdominal aortic aneurysm (AAA) and left renal cell carcinoma (RCC). The patient was an 81-year old man who presented with vague abdominal pain. The investigations revealed a 110*73*62 mm AAA together with 69*56 left renal mass. Read More

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http://dx.doi.org/10.34172/jcvtr.2020.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321004PMC
January 2020

Exercise improves aging-related decreased angiogenesis through modulating VEGF-A, TSP-1 and p-NF-Ƙb protein levels in myocardiocytes.

J Cardiovasc Thorac Res 2020 18;12(2):129-135. Epub 2020 May 18.

Neurophysiology Research Center, Cellular and Molecular Medicine Institute,Urmia University of Medical Sciences, Urmia, Iran.

Aging-dependent decline in the angiogenesis of heart is a risk factor for cardiovascular disease. This study was aimed to characterize effect of exercise on angiogenesis alterations and molecular mediators which are related to angiogenesis in the heart under aging condition. Twenty-one male Wistar rats were assigned into three groups: young, aged, and exercise. Read More

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http://dx.doi.org/10.34172/jcvtr.2020.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321007PMC

Emerging Roles of Mast Cells in the Regulation of Lymphatic Immuno-Physiology.

Front Immunol 2020 17;11:1234. Epub 2020 Jun 17.

Department of Medical Physiology, Texas A&M University Health Science Center College of Medicine, Bryan, TX, United States.

Mast cells (MCs) are abundant in almost all vascularized tissues. Furthermore, their anatomical proximity to lymphatic vessels and their ability to synthesize, store and release a large array of inflammatory and vasoactive mediators emphasize their significance in the regulation of the lymphatic vascular functions. As a major secretory cell of the innate immune system, MCs maintain their steady-state granule release under normal physiological conditions; however, the inflammatory response potentiates their ability to synthesize and secrete these mediators. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311670PMC

Evidence for Reciprocal Structural Network Interactions Between Bilateral Crus Lobes and Broca's Complex.

Front Neuroanat 2020 18;14:27. Epub 2020 Jun 18.

Department of Neurosurgery, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, China.

While the proximal dentatothalamocortical tracts are considered pivotal in the occurrence of cerebellar mutism syndrome (CMS) after medulloblastoma resection, how the cerebellum participates in motor-speech networks through direct structural connectivity is still unclear. tractography, we provide evidence of cerebellar streamlines projecting into the left inferior frontal gyrus majorly connecting Broca's complex and the bilateral Crus lobes. The streamlines, named Crus-Broca tracts, originated from the bilateral Crus lobes, synapsed onto the dentate nucleus, ascended into the superior cerebellar peduncle (where these streamlines were closely superior to the superior border of the supratonsillar cleft and the superolateral roof of the fourth ventricle), surprisingly bypassed the left red nucleus and the left thalamus, and ended at the subregions of Broca's complex. Read More

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http://dx.doi.org/10.3389/fnana.2020.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316155PMC

Anatomical and physiological considerations in scleral lens wear: Conjunctiva and sclera.

Cont Lens Anterior Eye 2020 Jul 2. Epub 2020 Jul 2.

Queensland University of Technology (QUT), Centre for Vision and Eye Research, School of Optometry and Vision Science, Contact Lens and Visual Optics Laboratory, Institute of Health and Biomedical Innovation, Queensland, Australia. Electronic address:

While scleral lenses have been fitted using diagnostic lenses or impression moulding techniques for over a century, recent advances in anterior segment imaging such as optical coherence tomography and corneo-scleral profilometry have significantly improved the current understanding of the anatomy of the anterior eye including the morphometry of the conjunctiva, sclera, and corneo-scleral junction, as well as the ocular surface shape and elevation. These technological advances in ocular imaging along with continual improvements and innovations in scleral lens design and manufacturing have led to a global increase in scleral lens prescribing. This review provides a comprehensive overview of the conjunctiva and sclera in the context of modern scleral lens practice, including anatomical variations in healthy and diseased eyes, the physiological impact of scleral lens wear, potential fitting challenges, and current approaches to lens modifications in order to minimise lens-induced complications and adverse ocular effects. Read More

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http://dx.doi.org/10.1016/j.clae.2020.06.005DOI Listing

Trans-diaphragmatic Pathologies: Anatomical Background and Spread of Disease on Cross-sectional Imaging.

Curr Probl Diagn Radiol 2020 Jun 1. Epub 2020 Jun 1.

Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

The diaphragm is not only a sheet of muscle separating the abdominal and thoracic cavities: it plays an essential role in ventilation and can act as a gateway for the spread of different disease processes between the abdominal and the thoracic cavity. Careful attention to the appearance of the diaphragm on various imaging modalities is essential to ensure the accurate diagnosis of diaphragmatic disorders, which may be secondary to functional or anatomical derangements. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2020.05.007DOI Listing

Editorial Commentary: The Menisco-Tibio-Popliteus-Fibular Complex: As Simple as Possible, But Not Simpler.

Authors:
Mathieu Thaunat

Arthroscopy 2020 Jul;36(7):1926-1927

Centre Orthopédique Santy.

Meniscus extrusion often occurs in the presence of significant knee pathology, predominantly with meniscus tears or osteoarthritis. In patients with isolated meniscal extrusion and an intact meniscus or minimal knee pathology, menisco-tibial ligament abnormality is likely. More detailed knowledge of this anatomical region is needed before we can develop specific treatments that faithfully reproduce the anatomical configuration. Read More

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http://dx.doi.org/10.1016/j.arthro.2020.04.015DOI Listing

A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations.

Skelet Muscle 2020 Jul 6;10(1):19. Epub 2020 Jul 6.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.

Single-cell RNA-sequencing (scRNA-seq) facilitates the unbiased reconstruction of multicellular tissue systems in health and disease. Here, we present a curated scRNA-seq dataset of human muscle samples from 10 adult donors with diverse anatomical locations. We integrated ~ 22,000 single-cell transcriptomes using Scanorama to account for technical and biological variation and resolved 16 distinct populations of muscle-resident cells using unsupervised clustering of the data compendium. Read More

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http://dx.doi.org/10.1186/s13395-020-00236-3DOI Listing

Pregnancy with Covid-19: Management considerations for care of severe and critically ill cases.

Am J Reprod Immunol 2020 Jul 4:e13299. Epub 2020 Jul 4.

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Pregnant women are a potentially highly vulnerable population due to anatomical, physiological and immunological changes under the Covid-19 pandemic. Issues related to pregnancy with Covid-19 attracted widespread attention from researchers. A large number of articles were published aiming to elaborate clinical characteristics and outcomes of pregnant women infected with Covid-19, in order to provide evidence for management. Read More

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http://dx.doi.org/10.1111/aji.13299DOI Listing

Successful Pain Relief by Local Injection Under Ultrasound Guidance in a Patient with Anatomical Abnormality of Cervical 5 Nerve Root.

Pain Ther 2020 Jul 4. Epub 2020 Jul 4.

Department of Anesthesiology, Tongzhou People's Hospital, Nantong, 226300, China.

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http://dx.doi.org/10.1007/s40122-020-00179-zDOI Listing

Malignant Leakage After Sleeve Gastrectomy: Endoscopic and Surgical Approach.

Obes Surg 2020 Jul 4. Epub 2020 Jul 4.

General Endocrine Surgery Department, Lille University Hospital CHU Lille, Lille, France.

Purpose: Gastric leak occurs after sleeve gastrectomy (SG) in 2% of cases. Most staple-line disruptions (SLD) can be successfully treated with first-line endoscopic procedures. Less favorable situations may lead to more complex therapeutic strategies, like conversion to Roux-en-Y gastric bypass (RYGBP). Read More

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http://dx.doi.org/10.1007/s11695-020-04818-4DOI Listing

Ischemia and outcome prediction by cardiac CT based machine learning.

Int J Cardiovasc Imaging 2020 Jul 4. Epub 2020 Jul 4.

Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Heart & Vascular Center, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC, 29425-2260, USA.

Cardiac CT using non-enhanced coronary artery calcium scoring (CACS) and coronary CT angiography (cCTA) has been proven to provide excellent evaluation of coronary artery disease (CAD) combining anatomical and morphological assessment of CAD for cardiovascular risk stratification and therapeutic decision-making, in addition to providing prognostic value for the occurrence of adverse cardiac outcome. In recent years, artificial intelligence (AI) and, in particular, the application of machine learning (ML) algorithms, have been promoted in cardiovascular CT imaging for improved decision pathways, risk stratification, and outcome prediction in a more objective, reproducible, and rational manner. AI is based on computer science and mathematics that are based on big data, high performance computational infrastructure, and applied algorithms. Read More

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http://dx.doi.org/10.1007/s10554-020-01929-yDOI Listing

The role of MRI pelvimetry in predicting technical difficulty and outcomes of open and minimally invasive total mesorectal excision: a systematic review.

Tech Coloproctol 2020 Jul 4. Epub 2020 Jul 4.

Surgical Outcomes Research Centre (SOuRCe), Sydney, Australia.

Background: The difficulty of performing total mesorectal excision (TME) for rectal cancer partly relies on the surgeon's subjective assessment of the individual patient's pelvic anatomy and tumour characteristics, which generally influences the choice of platform used (open, laparoscopic, robotic or trans-anal surgery). Recent studies have found associations between several anatomical pelvic measurements and surgical difficulty. The aim of this study was to systematically review existing data reporting the use of magnetic resonance imaging (MRI)-based pelvic measurements to predict technical difficulty and outcomes of TME, and determine whether pelvimetry could optimise patient-specific selection of a particular surgical approach. Read More

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http://dx.doi.org/10.1007/s10151-020-02274-xDOI Listing

Teratocarcinoma-derived growth factor-1 (Cripto-1) is overexpressed in epithelial odontogenic lesions displaying more aggressive behaviour.

Oral Maxillofac Surg 2020 Jul 5. Epub 2020 Jul 5.

Oral Pathology, Department of Dentistry, Federal University of Rio Grande do Norte-UFRN, Av. Sen Salgado Filho, 1787, Lagoa Nova, Natal, RN, Brazil.

Purpose: Cripto-1 also known as teratoma-derived growth factor 1 (TDGF-1) belongs to the EGF-CFC family of growth factor-like molecules. Cripto-1 is involved with embryonic development and not expressed in adult tissue, but some tumours are accompanied by reactivation.

Methods: The aim of this study was to evaluate the immunohistochemical expression of Cripto-1 in most common odontogenic cysts and tumours. Read More

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http://dx.doi.org/10.1007/s10006-020-00877-0DOI Listing

Bifascicular nature of the flexor digitorum profundus and flexor pollicis longus tendons: forgotten anatomical characteristics rediscovered with US imaging.

Eur Radiol 2020 Jul 4. Epub 2020 Jul 4.

Service d'imagerie médicale, CHU de Toulouse-Purpan, Bâtiment Pierre Paul Riquet,, Place du Dr Baylac, TSA, 40031-31059, Toulouse, France.

Objectives: To demonstrate the bifid configuration of the flexor digitorum profundus (FDP) and flexor pollicis longus (FPL).

Methods: In the first part of this study, 20 digits from 4 cadaver hands were dissected and analyzed using anatomical and histological slices. The second part of the study was carried out over a 12-month period starting in August 2018. Read More

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http://dx.doi.org/10.1007/s00330-020-07048-5DOI Listing

The midterm results of thoracic endovascular aortic repair with a precurved fenestrated endograft in zone 0-1.

Eur J Cardiothorac Surg 2020 Jul 5. Epub 2020 Jul 5.

Department of Cardiovascular Surgery, Tokyo Women's Medical University, The Heart Institute of Japan, Shinjukuku, Tokyo, Japan.

Objectives: Thoracic endovascular aortic repair (TEVAR) for the treatment of aortic arch disease remains challenging due to certain anatomical and haemodynamic features. The purpose of this study was to evaluate the midterm results of TEVAR with a second-generation fenestrated endograft for aortic arch disease.

Methods: This non-randomized, interventional study was part of a multicentre clinical trial conducted between 2010 and 2011 and was designed to assess the effectiveness of a second-generation precurved fenestrated endograft for aortic arch disease. Read More

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http://dx.doi.org/10.1093/ejcts/ezaa165DOI Listing

Comparison of optimal screw configurations in two locking plate systems for proximal humerus fixation - a finite element analysis study.

Clin Biomech (Bristol, Avon) 2020 Jun 27;78:105097. Epub 2020 Jun 27.

AO Research Institute Davos, Davos, Switzerland.

Background: Management of proximal humerus fractures is challenging, especially in elderly. Locking plating is a common surgical treatment option. The Proximal Humerus Internal Locking System (plate-A) has shown to lower complication rates compared to conventional plates, but is associated with impingement risk, which could be avoided using Peri-articular Proximal Humerus Plate (plate-B). Read More

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http://dx.doi.org/10.1016/j.clinbiomech.2020.105097DOI Listing

Deep neural networks for ECG-free cardiac phase and end-diastolic frame detection on coronary angiographies.

Comput Med Imaging Graph 2020 Jun 25;84:101749. Epub 2020 Jun 25.

Digital Services, Digital Technology & Innovation, Siemens Healthineers, 755 College Road, Princeton, 08540 NJ, USA.

Invasive coronary angiography (ICA) is the gold standard in Coronary Artery Disease (CAD) imaging. Detection of the end-diastolic frame (EDF) and, in general, cardiac phase detection on each temporal frame of a coronary angiography acquisition is of significant importance for the anatomical and non-invasive functional assessment of CAD. This task is generally performed via manual frame selection or semi-automated selection based on simultaneously acquired ECG signals - thus introducing the requirement of simultaneous ECG recordings. Read More

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http://dx.doi.org/10.1016/j.compmedimag.2020.101749DOI Listing

Zika virus infection causes widespread damage to the inner ear.

Hear Res 2020 Jun 29;395:108000. Epub 2020 Jun 29.

Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, 39202, USA. Electronic address:

Zika virus (ZIKV) has been recently recognized as a causative agent of newborn microcephaly, as well as other neurological consequences. A less well recognized comorbidity of prenatal ZIKV infection is hearing loss, but cases of hearing impairment following adult ZIKV infection have also been recognized. Diminished hearing following prenatal ZIKV infection in a mouse model has been reported, but no cellular consequences were observed. Read More

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http://dx.doi.org/10.1016/j.heares.2020.108000DOI Listing

Two of a kind? Immunological and clinical risk factors differ between recurrent implantation failure and recurrent miscarriage.

J Reprod Immunol 2020 Jun 20;141:103166. Epub 2020 Jun 20.

Department of Gynecological Endocrinology and Fertility Disorders, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany. Electronic address:

Recurrent miscarriage (RM) and recurrent implantation failure (RIF) are unsolved challenges in reproductive medicine. Whether RIF patients share the same risk factors as RM patients is a matter of debate. Besides clinical factors, immune alterations are discussed in both conditions. Read More

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http://dx.doi.org/10.1016/j.jri.2020.103166DOI Listing

The space for memory in posterior parietal cortex: Re-analyses of bottom-up attention data.

Neuropsychologia 2020 Jul 2:107551. Epub 2020 Jul 2.

Department of Psychology, University of Toronto, 100 St. George Street, Toronto, Canada; Rotman Research Institute, Baycrest, 3560, Bathurst Street, Toronto, Canada. Electronic address:

The ventral (VPC) and dorsal sectors of the posterior parietal cortex are long known to mediate bottom-up and top-down attention to the external space. Because these regions also are implicated in retrieval of episodic memories, we proposed they also mediate attention to the internal (memory) space. One objection to this Attention to Memory hypothesis is that parietal regions involved in directing attention to percepts and memory are spatially adjacent but not overlapping, suggesting that different neural mechanisms are involved in each. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2020.107551DOI Listing

Automated Detection of Subthalamic Nucleus in Deep Brain Stimulation Surgery for Parkinson's disease using Microelectrode Recordings and Wavelet Packet Features.

J Neurosci Methods 2020 Jul 2:108826. Epub 2020 Jul 2.

Department of Neurosurgery, National Neuroscience Institute, Singapore; Department of Neurosurgery, Singapore General Hospital, Singapore; Duke- NUS Medical School, Singapore.

Background: Deep brain stimulation (DBS) to the subthalamic nucleus (STN) is an effective neurosurgery that overcomes the motor system alternations of patients with advanced Parkinson's disease. The most challenging aspect of DBS surgery is the accurate identification of STN and its borders. In general, it is performed manually by a neurophysiologist using the microelectrode recordings (MERs). Read More

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http://dx.doi.org/10.1016/j.jneumeth.2020.108826DOI Listing

Technical Consideration of Interlaminar Approach in the Lumbar Disc Herniation.

World Neurosurg 2020 Jul 2. Epub 2020 Jul 2.

Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan; School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; College of nursing and health sciences, Dayeh University, Taiwan. Electronic address:

With the evolution of endoscopic instruments and techniques, full-endoscopic spine surgery(FESS) has attracted more attention worldwide in recent years. At the initial stage, surgeons conducted endoscopic lumbar discectomy by the transforaminal approach. Then, interlaminar endoscopic lumbar discectomy(IELD) was brought in treating herniation disc at the L5-S1 level. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.211DOI Listing

The anatomy and function of a bilateral accessory flexor digitorum superficialis muscle: A case report and review of literature.

Morphologie 2020 Jul 1. Epub 2020 Jul 1.

Orthopaedic Biomechanics Laboratory, Congress Medical Foundation, Pasadena, CA, USA.

Anatomical variations of the flexor digitorum superficialis (FDS) include variations of the muscle belly and/or tendon. We present a case of a bilateral accessory FDS muscle and tendon. Dissection was performed in a male specimen (56 years), where an unusual variation was found: a bilateral accessory FDS muscle and tendon. Read More

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http://dx.doi.org/10.1016/j.morpho.2020.06.002DOI Listing

Three-dimensional co-culture of human spermatogonial stem cells with Sertoli cells in soft agar culture system supplemented by growth factors and Laminin.

Acta Histochem 2020 Jul 13;122(5):151572. Epub 2020 Jun 13.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Application of a three-dimensional (3D) culture system for in vitro proliferation and differentiation of human spermatogonial stem cells (SSCs) is a useful tool for the investigation of the spermatogenesis process and the management of male infertility particularly in prepubertal cancer patients. The main purpose of this study was to investigate the proliferation of human SSCs co-cultured with Sertoli cells in soft agar culture system (SACS) supplemented by Laminin and growth factors. Testicular cells were isolated from testes of brain-dead patients and cultured in two-dimensional (2D) culture system for 3 weeks. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151572DOI Listing

Accuracy and efficiency of an artificial intelligence tool when counting breast mitoses.

Diagn Pathol 2020 Jul 4;15(1):80. Epub 2020 Jul 4.

Department of Pathology, Samsung Medical Center, Seoul, South Korea.

Background: The mitotic count in breast carcinoma is an important prognostic marker. Unfortunately substantial inter- and intra-laboratory variation exists when pathologists manually count mitotic figures. Artificial intelligence (AI) coupled with whole slide imaging offers a potential solution to this problem. Read More

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http://dx.doi.org/10.1186/s13000-020-00995-zDOI Listing

The relationship between tibiofemoral geometry and musculoskeletal function during normal activity.

Gait Posture 2020 Jun 26;80:374-382. Epub 2020 Jun 26.

Medical Device Research Institute, College of Science and Engineering, Flinders University, Bedford Park, Australia.

Background: The effect of tibiofemoral geometry on musculoskeletal function is important to movement biomechanics.

Research Question: We hypothesised that tibiofemoral geometry determines tibiofemoral motion and musculoskeletal function. We then aimed at 1) modelling tibiofemoral motion during normal activity as a function of tibiofemoral geometry in healthy adults; and 2) quantifying the effect of tibiofemoral geometry on musculoskeletal function. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.06.022DOI Listing

Impact of extracellular folic acid levels on oviductal gene expression.

Theriogenology 2020 May 21;154:161-170. Epub 2020 May 21.

Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Chacabuco 461, T4000ILI, San Miguel de Tucumán, Tucumán, Argentina; Instituto de Biología "Dr. Francisco D. Barbieri", Facultad de Bioquímica, Química y Farmacia, UNT, Chacabuco 461, T4000ILI, San Miguel de Tucumán, Tucumán, Argentina. Electronic address:

Folate plays a specific role as methyl donor for nucleotide synthesis and genomic methylation patterns, which in turn are important epigenetic determinants in gene expression. Previous studies have revealed the presence of folate in bovine oviductal fluid as well as the existence of a fine-tuned regulation of the gene expression of folate receptors and transporters in bovine oviduct epithelial cells (BOECs). However, the functional implications of folate in the oviduct remain unknown. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.05.022DOI Listing

Perforation of gastric volvulus within a giant hiatus hernia secondary to alendronate: A rare complication of bisphosphonate use.

Int J Surg Case Rep 2020 Jun 20;73:5-8. Epub 2020 Jun 20.

Department of Surgery, Redcliffe Hospital, Anzac Avenue, Redcliffe, QLD, Australia.

Introduction: Bisphosphonates are commonly used in the treatment of metabolic bone disease. However, they are associated with gastrointestinal side effects including acid reflux, mucosal erosion, and oesophageal stricture. We present a rare case of alendronate causing perforated gastric volvulus in a patient with giant hiatus hernia. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.068DOI Listing

Prediction of inter-fractional radiotherapy dose plans with domain translation in spatiotemporal embeddings.

Med Image Anal 2020 May 17;64:101728. Epub 2020 May 17.

Polytechnique Montréal, Montréal, Québec, Canada; CHUM Research Center, Montréal, Québec, Canada. Electronic address:

External beam radiation therapy fractions have become extremely complex and tedious procedures to plan, due to stringent requirements of delivering the highest radiation dose to the tumor while maximally avoiding organs at risk. However, due to anatomic and/or biological changes between fractions, dose re-optimization may be needed. Re-optimization is a time-consuming task which is typically triggered based on subjective visual assessment by an experienced physician. Read More

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http://dx.doi.org/10.1016/j.media.2020.101728DOI Listing

Investigation of correlation between bony pelvis dimensions and pelvic organ prolapse in different compartments.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 16;252:213-217. Epub 2020 Jun 16.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China.

Objective: To investigate the association between bony pelvis dimensions and anterior, apical, and posterior compartment pelvic organ prolapse (POP) and explore the mechanism of different types of POP from an anatomical point of view.

Study Design: A total of 253 patients with POP were selected as the experimental group (138 patients with anterior compartment defect, 86 with apical compartment defect, and 29 with posterior compartment defect); 253 patients with uterine myoma constituted the control group. Their demographics were recorded, and anteroposterior diameters of the pelvic inlet, intertuberous diameter, and interspinous diameter were measured. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.026DOI Listing