147,049 results match your criteria Anatomical record Hoboken N.J. : 2007[Journal]


An investigation of the detection capability of pulsed wave duplex Doppler of low grade stenosis using ultrasound contrast agent microbubbles - An in-vitro study.

Ultrasonics 2019 Apr 11;96:48-54. Epub 2019 Apr 11.

Medical Physics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.

Objective: The objective of the study was to investigate whether clinically used ultrasonic contrast agents improved the accuracy of spectral Doppler ultrasound in the detection of low grade (<50%) renal artery stenosis. Low grade stenoses in the renal artery are notoriously difficult to reliably detect using Doppler ultrasound due to difficulties such as overlying fat and bowel gas.

Methods: A range of anatomically-realistic renal artery phantoms with varying low degrees of stenosis (0, 30 and 50%) were constructed and peak velocity data was measured from within the pre-stenotic and mid-stenotic regions in each phantom, for both unenhanced and contrast-enhanced spectral Doppler data acquisitions. Read More

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http://dx.doi.org/10.1016/j.ultras.2019.04.003DOI Listing

Effect of Implantation Site on Outcome of Tissue-Engineered Vascular Grafts.

Eur J Pharm Biopharm 2019 Apr 17. Epub 2019 Apr 17.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211 Geneva, Switzerland.

Objective: Vascular prostheses for small caliber bypass grafts in cardiac and vascular diseases or for access surgery are still missing. Poly (Ɛ-caprolactone) (PCL) has been previously investigated by our group and showed good biocompatibility and mechanical properties in vitro and rapid endothelialisation, cellular infiltration and vascularisation in vivo yielding optimal patency in the abdominal aortic position. The aim of the present study is to evaluate our PCL graft in the carotid position and to compare its outcome to the grafts implanted in the abdominal aortic position. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09396411193002
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http://dx.doi.org/10.1016/j.ejpb.2019.04.012DOI Listing
April 2019
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Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation.

J Am Acad Child Adolesc Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

University of Vermont, Burlington; Vermont Center on Behavior and Health, University of Vermont, Burlington.

Objective: To characterize the structural and functional neurobiology of a large group of adolescents exhibiting a behaviorally and emotionally dysregulated phenotype.

Method: Age 14 adolescents from the IMAGEN study were investigated. Latent class analysis (LCA) on the Strengths and Difficulties Questionnaire (SDQ) was used to identify a class of individuals with elevated behavioral and emotional difficulties ("dysregulated"; n=233) who were compared to a matched sample from a low symptom class (controls, n=233). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193026
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http://dx.doi.org/10.1016/j.jaac.2019.01.021DOI Listing
April 2019
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The contribution of KSHV to mortality in hospitalized HIV-infected patients being investigated for tuberculosis in South Africa.

J Infect Dis 2019 Apr 20. Epub 2019 Apr 20.

Division of Medical Biochemistry and Structural Biology, Department of Integrative Biomedical Sciences, University of Cape Town, South Africa.

Background: Despite increasing numbers of human immunodeficiency virus (HIV)-infected South Africans receiving antiretroviral therapy (ART), tuberculosis remains the leading cause of mortality. Approximately 25% of patients treated for tuberculosis have microbiologically unconfirmed diagnoses. We assessed whether elevated Kaposi's sarcoma-associated Herpes Virus (KSHV) viral load (VL) contributes to mortality in hospitalized HIV-infected patients investigated for tuberculosis. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz180DOI Listing
April 2019
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Manual for clinical language tractography.

Acta Neurochir (Wien) 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: We introduce a user-friendly, standardized protocol for tractography of the major language fiber bundles.

Method: The introduced method uses dMRI images for tractography whereas the ROI definition is based on structural T1 MPRAGE MRI templates, without normalization to MNI space. ROIs for five language-relevant fiber bundles were visualized on an axial, coronal, or sagittal view of T1 MPRAGE images. Read More

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http://link.springer.com/10.1007/s00701-019-03899-0
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http://dx.doi.org/10.1007/s00701-019-03899-0DOI Listing
April 2019
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ASYMMETRIC LEAVES1 and REVOLUTA are the key regulatory genes associated with pitcher development in Nepenthes khasiana.

Sci Rep 2019 Apr 19;9(1):6318. Epub 2019 Apr 19.

Stress Physiology and Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.

Nepenthes develops highly specialized insect-eating organs called pitchers that provide adequate insect-derived nutrients to the plants to offset low nutrient availability in their natural habitat. But so far, the molecular basis of Nepenthes pitcher development remains largely unknown. In an attempt to unravel the underlying mechanisms of pitcher formation, we made morphological observations of the developing N. Read More

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http://dx.doi.org/10.1038/s41598-019-42779-6DOI Listing

Temporal lobe epilepsy: Hippocampal pathology modulates connectome topology and controllability.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Neuroimaging of Epilepsy Laboratory (B.C.B., F.F., M.L., B.C., A.B., N.B.) and Multimodal Imaging and Connectome Analysis Laboratory (B.C.B.), McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Canada; Department of Bioengineering and Electrical and Systems Engineering (S.G., D.S.B.), University of Pennsylvania, Philadelphia; and York Neuroimaging Center (E.J., J.S.), University of York, UK.

Objective: To assess whether hippocampal sclerosis (HS) severity is mirrored at the level of large-scale networks.

Methods: We studied preoperative high-resolution anatomical and diffusion-weighted MRI of 44 temporal lobe epilepsy (TLE) patients with histopathologic diagnosis of HS (n = 25; TLE-HS) and isolated gliosis (n = 19; TLE-G) and 25 healthy controls. Hippocampal measurements included surface-based subfield mapping of atrophy and T2 hyperintensity indexing cell loss and gliosis, respectively. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007447DOI Listing
April 2019
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The Selective Expansion and Targeted Accumulation of Bone Marrow-Derived Macrophages Drive Cardiac Vasculitis.

J Immunol 2019 Apr 19. Epub 2019 Apr 19.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia;

The adult heart contains macrophages derived from both embryonic and adult bone marrow (BM)-derived precursors. This population diversity prompted us to explore how distinct macrophage subsets localize within the heart, and their relative contributions in cardiac disease. In this study, using the reciprocal expression of Lyve-1 and Ccr2 to distinguish macrophages with distinct origins, we show that, in the steady state, both embryonic (Lyve) and BM-derived (Ccr2) macrophages populate the major vessels of the heart in mice and humans. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1900071
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http://dx.doi.org/10.4049/jimmunol.1900071DOI Listing
April 2019
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Global Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model.

ASN Neuro 2019 Jan-Dec;11:1759091419843393

1 Department of Pediatrics, Biological Sciences Division, The University of Chicago, IL, USA.

In humans, homozygous mutations in the TPP1 gene results in loss of tripeptidyl peptidase 1 (TPP1) enzymatic activity, leading to late infantile neuronal ceroid lipofuscinoses disease. Using a mouse model that targets the Tpp1 gene and recapitulates the pathology and clinical features of the human disease, we analyzed end-stage (4 months) transcriptional changes associated with lack of TPP1 activity. Using RNA sequencing technology, Tpp1 expression changes in the forebrain/midbrain and cerebellum of 4-month-old homozygotes were compared with strain-related controls. Read More

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http://dx.doi.org/10.1177/1759091419843393DOI Listing
April 2019
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Validation of a freehand technique for cortical bone trajectory screws in the lumbar spine.

J Neurosurg Spine 2019 Apr 19:1-8. Epub 2019 Apr 19.

1Division of Orthopaedic Surgery, University of Toronto, Toronto.

OBJECTIVEThe cortical bone trajectory (CBT) technique for pedicle screw placement has gained popularity among spinal surgeons. It has been shown biomechanically to provide better fixation and improved pullout strength compared to a traditional pedicle screw trajectory. The CBT technique also allows for a less invasive approach for fusion and may have lower incidence of adjacent-level disease. Read More

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https://thejns.org/view/journals/j-neurosurg-spine/aop/artic
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http://dx.doi.org/10.3171/2019.1.SPINE181402DOI Listing
April 2019
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Comprehensive anatomy of the foramen ovale critical to percutaneous stereotactic radiofrequency rhizotomy: cadaveric study of dry skulls.

J Neurosurg 2019 Apr 19:1-9. Epub 2019 Apr 19.

1Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota.

OBJECTIVEPercutaneous stereotactic radiofrequency rhizotomy (PSR) is often used to treat trigeminal neuralgia, a serious condition that results in lancinating, episodic facial pain. Thorough understanding of the microsurgical anatomy of the foramen ovale (FO) and its surrounding structures is required for efficient, effective, and safe use of this technique. This morphometric study compares anatomical and surgical orientations to identify the variations of the FO and assess cannulation difficulty. Read More

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http://dx.doi.org/10.3171/2019.1.JNS18899DOI Listing

Full tractography for detecting the position of cranial nerves in preoperative planning for skull base surgery: technical note.

J Neurosurg 2019 Apr 19:1-11. Epub 2019 Apr 19.

4Department of Neurosurgery, Stanford University Medical Center, Stanford, California.

OBJECTIVEDiffusion imaging tractography has allowed the in vivo description of brain white matter. One of its applications is preoperative planning for brain tumor resection. Due to a limited spatial and angular resolution, it is difficult for fiber tracking to delineate fiber crossing areas and small-scale structures, in particular brainstem tracts and cranial nerves. Read More

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http://dx.doi.org/10.3171/2019.1.JNS182638DOI Listing

Comparison of glenohumeral and humerothoracical range of motion in healthy controls, osteoarthritic patients and patients after total shoulder arthroplasty performing different activities of daily living.

Gait Posture 2019 Apr 6;71:20-25. Epub 2019 Apr 6.

Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany. Electronic address:

Purpose: The purpose of this study was to examine how total shoulder arthroplasty improves performance of activities of daily living compared to patients with glenohumeral osteoarthritis and how they perform compared to healthy controls.

Methods: Glenohumeral and humerothoracical elevation used by patients with primary osteoarthritis (12 participants, 16 shoulders), after total shoulder arthroplasty (16 participants, 24 shoulders) and healthy controls (11 participants, 22 shoulders) for four different activities of daily living were assessed using 3D motion analysis. Analysis of range of motion and angle time series was performed. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.04.001DOI Listing

Directional fast-marching and multi-model strategy to extract coronary artery centerlines.

Comput Biol Med 2019 Apr 5;108:67-77. Epub 2019 Apr 5.

School of Data Science, Fudan University, Shanghai, China. Electronic address:

Background: Computed tomography angiography (CTA) is a non-invasive technique to image coronary arteries and evaluate coronary artery diseases (CAD). The diagnosis of CAD requires modeling anatomical structures and analyzing the function and pathology of the coronary arteries. Therefore, a robust and automated method for extracting reliable coronary artery centerlines is valuable in clinical practice. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.029DOI Listing
April 2019
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Submucosal mucoid as a late complication after appendectomy-A case report.

Int J Surg Case Rep 2019 Apr 5;58:37-40. Epub 2019 Apr 5.

Radiological Department, Klatovy Hospital, Plzeňská 929, 339 01, Klatovy II, Czech Republic.

Introduction: Shortly after an operation infection, intraabdominal abscess, seroma, haemorrhage or development of paralytic ileus may occur. Postoperative adhesions, nonspecific abdominal pain without signs of obstruction, incisional hernia and appendicitis or mucocele in appendiceal stump present common late complications. We present a unique case of a late complication after appendectomy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193017
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http://dx.doi.org/10.1016/j.ijscr.2019.03.051DOI Listing
April 2019
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[Do we need to perform systematic supracervical hysterectomy during laparoscopic sacrocolpopexy?]

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Département de Gynécologie-Obstétrique, Université de Liège, Centre Hospitalier Régional de la Citadelle, Boulevard du 12(e) de Ligne, 1, 4000 Liège, Belgique.

Objective: To evaluate the place of subtotal hysterectomy during laparoscopic sacrocolpopexy.

Methods: This retrospective observational study includes patients undergoing laparoscopic sacrocolpopexy between November 2010 and March 2015 at the Centre Hospitalier Régional de la Citadelle, Liège, Belgium. Patient characteristics, medical and surgical history were collected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687189193015
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http://dx.doi.org/10.1016/j.gofs.2019.04.007DOI Listing
April 2019
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Dependence of resting-state fMRI fluctuation amplitudes on cerebral cortical orientation relative to the direction of B0 and anatomical axes.

Neuroimage 2019 Apr 16. Epub 2019 Apr 16.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th St., Charlestown, Boston, MA 02129, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA, USA. Electronic address:

Functional magnetic resonance imaging (fMRI) is now capable of sub-millimetre scale measurements over the entire human brain, however with such high resolutions each voxel is influenced by the local fine-scale details of the cerebral cortical vascular anatomy. The cortical vasculature is structured with the pial vessels lying tangentially along the grey matter surface, intracortical diving arterioles and ascending venules running perpendicularly to the surface, and a randomly oriented capillary network within the parenchyma. It is well-known that the amplitude of the blood-oxygenation level dependent (BOLD) signal emanating from a vessel depends on its orientation relative to the Bfield. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.04.036DOI Listing

A comparative study of the pharyngeal plate of Apoidea (Hymenoptera: Aculeata), with implications for the understanding of phylogenetic relationships of bees.

Arthropod Struct Dev 2019 Apr 16. Epub 2019 Apr 16.

Laboratório de Biologia Comparada e Abelhas (LBCA) - Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo, 14040-901, Ribeirão Preto, SP, Brazil. Electronic address:

The pharyngeal plate is a morphological complex with extensive anatomical variation among bees and, therefore, potential as a source of phylogenetic information. The pharyngeal plate of bees is divided into four morphologically distinct regions: sitophore, hypopharyngeal lobe, pharyngeal rods, and median oral plate. In this work we illustrate and document in detail for the first time the pharyngeal plate of 44 bee species, providing descriptions of the morphological variation and contrasting these findings with representatives of apoid wasps (Crabronidae and Sphecidae). Read More

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http://dx.doi.org/10.1016/j.asd.2019.04.002DOI Listing

Comparison of 3-Dimensional and Augmented Reality Kidney Models With Conventional Imaging Data in the Preoperative Assessment of Children With Wilms Tumors.

JAMA Netw Open 2019 Apr 5;2(4):e192633. Epub 2019 Apr 5.

Department of Pediatric Surgery, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

Importance: Nephron-sparing surgery can be considered in well-defined cases of unilateral and bilateral Wilms tumors, but the surgical procedure can be very challenging for the pediatric surgeon to perform.

Objective: To assess the added value of personalized 3-dimensional (3-D) kidney models derived from conventional imaging data to enhance preoperative surgical planning.

Design, Setting, And Participants: In a survey study, the conventional imaging data of 10 Dutch children with Wilms tumors were converted to 3-D prints and augmented reality (AR) holograms and a panel of pediatric oncology surgeons (n = 7) assessed the quality of the different imaging methods during preoperative evaluation. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2633DOI Listing

[Visualisation and Radiofrequency Ablation of Sympathetic Innervation Loci in the Left Atrium in Patients with Paroxysmal Atrial Fibrillation].

Kardiologiia 2019 Apr 16;59(4):33-38. Epub 2019 Apr 16.

National Medical Research Center named after acad. E. N. Meshalkin, Novosibirsk.

Introduction: A novel cardiac gamma camera utilizes the radiopharmaceutical Iodine-123-Meta-iodobenzylguanidine (123I-MIBG) to visualize cardiac sympathetic innervation. Physiological accumulation of 123I-mIBG provides an anatomical quantitative determination of the structures of the autonomic nervous system (ANS) with discrete uptake areas (DUA) of sympathetic activity located in the left atrium (LA) corresponding to the main ganglionic plexi (GP) clusters that could not previously be visualized.

Aim: to visualize the DUA of the heart in patients with paroxysmal atrial fibrillation (AF) and to assess the effect of radiofrequency ablation (RFA) on DUA in LA. Read More

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http://dx.doi.org/10.18087/cardio.2019.4.10249DOI Listing
April 2019
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Gibberellin repression of axillary bud formation in Arabidopsis by modulation of DELLA-SPL9 complex activity.

J Integr Plant Biol 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao 266237, China.

The formation of lateral branches has an important and fundamental contribution to the remarkable developmental plasticity of plants, which allows plant to alter their architecture to adapt to the challenging environment conditions. The Gibberellin (GA) phytohormones have been known to regulate the outgrowth of AMs, but the specific molecular mechanisms remain unclear. Here we show that DELLA proteins regulate axillary bud formation by interacting and regulating the DNA-binding ability of SQUAMOSA-PROMOTER BINDING PROTEIN LIKE 9 (SPL9), a microRNA156-targeted squamosa promoter binding protein-like transcription factor. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jipb.12818
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http://dx.doi.org/10.1111/jipb.12818DOI Listing
April 2019
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A novel player in the field: Merkel disk in touch, itch, and pain.

Exp Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, 63110, United States.

Mammalian skin, comprising both hairy and glabrous skin, is innervated by various types of low-threshold mechanoreceptors (LTMRs), which renders skin into a mechanosensitive organ [1]. Based on the degree of axonal myelination and conduction velocity, LTMRs are further divided into C-, Aδ- and Aβ-LTMRs. Electrophysiological recordings from those LTMRs have revealed unique action potential firing patterns upon discriminative mechanical stimuli. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13945
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http://dx.doi.org/10.1111/exd.13945DOI Listing
April 2019
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DNA barcoding uncovers extensive cryptic diversity in the African long-fin tetra Bryconalestes longipinnis (Alestidae: Characiformes).

J Fish Biol 2019 Apr 19. Epub 2019 Apr 19.

Department of Ichthyology, American Museum of Natural History, New York, New York, USA.

To investigate the presence of cryptic diversity in The African longfin-tetra Bryconalestes longipinnis, we employed DNA barcoding in a phylogeographic context, as well as geometric morphometrics, documenting for the first time genetic and body shape variation in the species. Analysis of cytochrome oxidase I gene (coI) sequence variation exposed extremely high levels of genetic differentiation among samples from across the geographic range of the species (up to 18%), certainly much greater than the traditionally employed c. 3% sequence divergence heuristic threshold for conspecifics. Read More

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http://dx.doi.org/10.1111/jfb.13987DOI Listing

Laparoscopic completion gastrectomy in elderly patients with remnant gastric cancer: a case series.

Surg Case Rep 2019 Apr 17;5(1):63. Epub 2019 Apr 17.

Department of Surgery, Saiseikai Yokohamashi Tobu Hospital, 3-6-1, Shimosueyoshi, Tsurumi-ku, Yokohama-shi, Kanagawa, 230-8765, Japan.

Background: Open completion gastrectomy (OCG) has been selected to treat remnant gastric cancer (RGC) due to severe adhesions and difficulty recognizing anatomical orientation after primary gastrectomy. In general, elderly individuals' physiological reserves gradually decrease. Moreover, elderly patients (EPs) often have multiple complicating factors (i. Read More

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http://dx.doi.org/10.1186/s40792-019-0610-0DOI Listing

A complex relation between depression and multiple sclerosis: a descriptive review.

Neurol Sci 2019 Apr 18. Epub 2019 Apr 18.

IRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113 Via Palermo, C.da Casazza, 98124, Messina, Italy.

Background: Multiple sclerosis (MS) is a demyelinating neurodegenerative disease that affects central nervous system (CNS). MS patients are more likely to develop depressive symptoms than patients with other chronic diseases.

Objective: In this review, we have analysed if there is a correlation between brain lesions (BL), structural damage (SD) and depressive symptoms (DS). Read More

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http://link.springer.com/10.1007/s10072-019-03889-1
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http://dx.doi.org/10.1007/s10072-019-03889-1DOI Listing
April 2019
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[Digital OR: better planning and communication].

Authors:
A Meppelink

HNO 2019 Apr 18. Epub 2019 Apr 18.

Brainlab AG, Olof-Palme-Straße 9, 81829, München, Deutschland.

At the center of digital ENT surgery are four primary technological developments: in addition to the potential of a digitalized operating room (OR), these are modern navigation approaches, planning software, and robotics-based assistance systems. In the OR of the future, not only will data enrichment and information integration play a role, but so will the incorporation of high-tech medical devices. Their use and the information they generate are simplified, while at the same time, further clinical data are optimized before, during, and after the surgical procedure. Read More

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http://link.springer.com/10.1007/s00106-019-0664-0
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http://dx.doi.org/10.1007/s00106-019-0664-0DOI Listing
April 2019
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Reviving the lost art of scleral buckling surgery for rhegmatogenous retinal detachment: evaluation of risk factors of detachments, poor physiological outcomes, and perspective from a developing country.

Ther Adv Ophthalmol 2019 Jan-Dec;11:2515841419838662. Epub 2019 Apr 7.

Lumbini Eye Institute, Lumbini, Nepal.

Purpose: To evaluate the primary anatomic and physiological success of scleral buckling surgery for rhegmatogenous retinal detachment and factors influencing its outcomes.

Methods: This is a prospective analytical study of 92 eyes that underwent scleral buckling at the Lumbini Eye Institute and Research Center, in Lumbini, Nepal. Parameters evaluated which could influence the outcome of the surgery included the lens status, duration of symptoms, locations of breaks, the extent of retinal detachment, and preoperative proliferative vitreoretinopathy. Read More

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http://dx.doi.org/10.1177/2515841419838662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454650PMC
April 2019
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A Computational Model of the Escape Response Latency in the Giant Fiber System of .

eNeuro 2019 Mar-Apr;6(2). Epub 2019 Apr 15.

Institute of Healthy Ageing, and GEE, University College London, London WC1E 6BT, United Kingdom.

The giant fiber system (GFS) is a multi-component neuronal pathway mediating rapid escape response in the adult fruit-fly , usually in the face of a threatening visual stimulus. Two branches of the circuit promote the response by stimulating an escape jump followed by flight initiation. A recent work demonstrated an age-associated decline in the speed of signal propagation through the circuit, measured as the stimulus-to-muscle depolarization response latency. Read More

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http://dx.doi.org/10.1523/ENEURO.0423-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469880PMC

Cross-Polarization Optical Coherence Tomography for Brain Tumor Imaging.

Front Oncol 2019 2;9:201. Epub 2019 Apr 2.

Laboratory of Optical Coherence Tomography, Research Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.

This paper considers valuable visual assessment criteria for distinguishing between tumorous and non-tumorous tissues, intraoperatively, using cross-polarization OCT (CP OCT)-OCT with a functional extension, that enables detection of the polarization properties of the tissues in addition to their conventional light scattering. The study was performed on 176 human specimens obtained from 30 glioma patients. To measure the degree to which the typical parameters of CP OCT images can be matched to the actual histology, 100 images of tumors and white matter were selected for visual analysis to be undertaken by three "single-blinded" investigators. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00201/
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http://dx.doi.org/10.3389/fonc.2019.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455095PMC
April 2019
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Lingual and Maxillary Labial Frenuloplasty with Myofunctional Therapy as a Treatment for Mouth Breathing and Snoring.

Case Rep Otolaryngol 2019 10;2019:3408053. Epub 2019 Mar 10.

The Breathe Institute, Los Angeles, CA, USA.

Chronic mouth breathing may adversely affect craniofacial development in children and may result in anatomical changes that directly impact the stability and collapsibility of the upper airway during sleep. Mouth breathing is a multifactorial problem that can be attributed to structural, functional, and neurological etiologies, which are not all mutually exclusive. While therapeutic interventions (myofunctional, speech and swallowing, occupational, and craniosacral therapy) may address the functional and behavioral factors that contribute to mouth breathing, progress may sometimes be limited by restrictive lingual and labial frenum that interfere with tongue and lip mobility. Read More

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http://dx.doi.org/10.1155/2019/3408053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437727PMC

Bilateral Bifid mandibular canals - Special relevance for a general dental practitioner. Report of 2 cases.

J Clin Exp Dent 2019 Mar 1;11(3):e287-e289. Epub 2019 Mar 1.

BDS. College of Medicine and Dentistry, James Cook University. Smithfield, Queensland - 4878. Australia.

Dental practitioners may encounter bifid mandibular canals upon radiographic assessment, and may not understand the true extent of this presentation. The presentation of a bifid mandibular canal poses difficulties when carrying out dental procedures, including administration of mandibular block anaesthesia, oral surgical procedures of the lower third molars, orthognathic surgery and implant placement. Therefore it is of paramount importance that general dental practitioners be aware of the radiographic appearance, as incorrect diagnosis of this rare presentation can lead to detrimental consequences. Read More

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http://dx.doi.org/10.4317/jced.55575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461729PMC

Frontal Anatomical Correlates of Cognitive and Speech Motor Deficits in Amyotrophic Lateral Sclerosis.

Behav Neurol 2019 13;2019:9518309. Epub 2019 Mar 13.

Sunnybrook Research Institute, Hurvitz Brain Sciences Program, Toronto, Canada.

The goal of this study was to identify neurostructural frontal lobe correlates of cognitive and speaking rate changes in amyotrophic lateral sclerosis (ALS). 17 patients diagnosed with ALS and 12 matched controls underwent clinical, bulbar, and neuropsychological assessment and structural neuroimaging. Neuropsychological testing was performed via a novel computerized frontal battery (ALS-CFB), based on a validated theoretical model of frontal lobe functions, and focused on testing energization, executive function, emotion processing, theory of mind, and behavioral inhibition via antisaccades. Read More

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http://dx.doi.org/10.1155/2019/9518309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436339PMC

Wood Growth in Pure and Mixed L. Forests: Drought Influence Depends on Site Conditions.

Front Plant Sci 2019 2;10:397. Epub 2019 Apr 2.

Department of Agricultural Sciences, University of Naples Federico II, Naples, Italy.

Climate response of tree-species growth may be influenced by intra- and inter-specific interactions. The different physiological strategies of stress response and resource use among species may lead to different levels of competition and/or complementarity, likely changing in space and time according to climatic conditions. Investigating the drivers of inter- and intra-specific interactions under a changing climate is important when managing mixed and pure stands, especially in a climate change hot spot such as the Mediterranean basin. Read More

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https://www.frontiersin.org/article/10.3389/fpls.2019.00397/
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http://dx.doi.org/10.3389/fpls.2019.00397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454142PMC
April 2019
2 Reads

Opposite T Response of ACTG1-FOS Subnetwork Differentiate Tailfin Fate in Xenopus Tadpole and Post-hatching Axolotl.

Front Endocrinol (Lausanne) 2019 2;10:194. Epub 2019 Apr 2.

Unité Mixte de Recherche 7221, Centre National de la Recherche Scientifique, Alliance Sorbonne Université, Muséum National d'Histoire Naturelle, Paris, France.

Amphibian post-embryonic development and Thyroid Hormones (TH) signaling are deeply and intimately connected. In anuran amphibians, TH induce the spectacular and complex process known as metamorphosis. In paedomorphic salamanders, at similar development time, raising levels of TH fail to induce proper metamorphosis, as many "larval" tissues (e. Read More

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http://dx.doi.org/10.3389/fendo.2019.00194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454024PMC

Deep Brain Stimulation Programming 2.0: Future Perspectives for Target Identification and Adaptive Closed Loop Stimulation.

Front Neurol 2019 3;10:314. Epub 2019 Apr 3.

Department of Neurology, Ludwig Maximilians University, Munich, Germany.

Deep brain stimulation has developed into an established treatment for movement disorders and is being actively investigated for numerous other neurological as well as psychiatric disorders. An accurate electrode placement in the target area and the effective programming of DBS devices are considered the most important factors for the individual outcome. Recent research in humans highlights the relevance of widespread networks connected to specific DBS targets. Read More

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http://dx.doi.org/10.3389/fneur.2019.00314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456744PMC

The Minimalist Program and the Origin of Language: A View From Paleoanthropology.

Authors:
Ian Tattersall

Front Psychol 2019 2;10:677. Epub 2019 Apr 2.

Division of Anthropology, American Museum of Natural History, New York, NY, United States.

In arguing that articulate language is underpinned by an algorithmically simple neural operation, the Minimalist Program (MP) retrodicts that language emerged in a short-term event. Because spoken language leaves no physical traces, its ancient use must be inferred from archeological proxies. These strongly suggest that modern symbolic human behavior patterns - and, by extension, cognition - emerged both abruptly and late in time (subsequent to the appearance of as an anatomical entity some 200 thousand years kyr ago). Read More

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https://www.frontiersin.org/article/10.3389/fpsyg.2019.00677
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http://dx.doi.org/10.3389/fpsyg.2019.00677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454856PMC
April 2019
1 Read

Planning C2 pedicle screw placement with multiplanar reformatted cervical spine computed tomography.

J Craniovertebr Junction Spine 2019 Jan-Mar;10(1):46-50

Department of Orthopedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, MS, USA.

Object: Careful preoperative planning with thin-slice computed tomography (CT) scan is useful for hardware placement at C2. Prior studies have shown considerable variability in the proportion of C2 vertebrae considered safe for pedicle screw placement, depending on the imaging technique used. Our work sought to more carefully define that proportion using a refined imaging technique on a large number of submillimeter CT scans. Read More

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http://dx.doi.org/10.4103/jcvjs.JCVJS_116_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469326PMC

Superficial anterior atlanto-occipital ligament: Anatomy of a forgotten structure with relevance to craniocervical stability.

J Craniovertebr Junction Spine 2019 Jan-Mar;10(1):42-45

Seattle Science Foundation, Seattle, WA, USA.

Introduction: The superficial anterior atlanto-occipital ligament (SAAOL) is a narrowband located anterior to the anterior atlanto-occipital membrane. Nearly forgotten, it has not been well described in older anatomical textbooks and is missing in the current anatomical literature. As all of the binding structures of the craniocervical junction (CCJ) are important in maintaining stability, this study aims to clarify the anatomy and potential function of the SAAOL. Read More

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http://www.jcvjs.com/text.asp?2019/10/1/42/255720
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http://dx.doi.org/10.4103/jcvjs.JCVJS_110_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469323PMC
April 2019
1 Read

Proposal of a new anatomical landmark to identify the disc space in endoscopic lumbar discectomy.

J Craniovertebr Junction Spine 2019 Jan-Mar;10(1):39-41

Department of Neurosurgery, International Neuroscience Institute, Hannover, Germany.

Introduction: In endoscopic lumbar discectomy for posterolateral disc herniation, we determined some anatomical landmarks for improved disc space access. These landmarks are based on the beginning of the insertion of the ligamentum flavum (LF) to vertebral lamina.

Materials And Methods: In 978 patients operated by posterolateral disc herniation, we measured prospectively the distance between the beginning of the insertion of the LF and space disc rostrally. Read More

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http://www.jcvjs.com/text.asp?2019/10/1/39/255719
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http://dx.doi.org/10.4103/jcvjs.JCVJS_103_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469320PMC
April 2019
1 Read

White matter microstructure reflects individual differences in music reward sensitivity.

J Neurosci 2019 Apr 18. Epub 2019 Apr 18.

Department of Cognition, Development and Educational Psychology, University of Barcelona, L'Hospitalet de Llobregat, 08097 Barcelona, Spain

People show considerable variability in the degree of pleasure they experience from music. These individual differences in music reward sensitivity are driven by variability in functional connectivity between the nucleus accumbens (NAcc), a key structure of the reward system, and the right superior temporal gyrus (STG). However, it is unknown whether a neuroanatomical basis exists for this variability. Read More

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.2020-1
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http://dx.doi.org/10.1523/JNEUROSCI.2020-18.2019DOI Listing
April 2019
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Anatomical and functional changes in neovascular AMD in remission: comparison of fibrocellular and fibrovascular phenotypes.

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, University Vita Salute, Hospital San Raffaele, Milano, Italy

Purpose: To investigate the anatomical changes and the macular function in neovascular age-related macular degeneration (AMD) eyes, according to the recognition of either fibrocellular or fibrovascular phenotype.

Methods: We enrolled eyes with previously treated neovascular AMD in remission (no subretinal haemorrhage, sign of fluid in or under the retina and no treatment for at least 6 months). Subjects underwent multimodal imaging assessment and were tested for macular sensitivity using microperimetry. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313685DOI Listing

Anatomical Correlation of the Helical Structure of the Ventricular Myocardium Through Echocardiography.

Rev Esp Cardiol (Engl Ed) 2019 Apr 15. Epub 2019 Apr 15.

Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico. Electronic address:

Introduction And Objectives: The helical structure of the ventricular myocardium provides a simple view of cardiac anatomy, based on physiological evidence that has been broadly demonstrated in experimental and imaging studies, and helps to explain the electromechanical contraction of the myocardium during the cardiac cycle. The aim of this study was to standardize and provide a detailed description of the technique for preparing and manually dissecting the myocardium proposed empirically by Torrent-Guasp. A further aim was to anatomically and topographically correlate the helical band with echocardiographic long-axis, short-axis, and 4-chamber projections. Read More

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http://dx.doi.org/10.1016/j.rec.2018.10.016DOI Listing

Anomalous Coronary Artery Origin and Sudden Cardiac Death: Clinical and Pathological Insights From a National Pathology Registry.

JACC Clin Electrophysiol 2019 Apr 30;5(4):516-522. Epub 2019 Jan 30.

Cardiovascular Pathology Department, St. George's, University of London, London, United Kingdom. Electronic address:

Objectives: This study sought to describe the clinical and pathological features of anomalous origin of a coronary artery (AOCA) in sudden cardiac death (SCD) victims.

Background: AOCA from the inappropriate sinus of Valsalva or from the pulmonary artery is increasingly diagnosed with current imaging techniques. AOCA is a possible cause of SCD. Read More

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http://dx.doi.org/10.1016/j.jacep.2018.11.015DOI Listing

Localization of Accessory Pathways in Pediatric Patients With Wolff-Parkinson-White Syndrome Using 3D-Rendered Electromechanical Wave Imaging.

JACC Clin Electrophysiol 2019 Apr 30;5(4):427-437. Epub 2019 Jan 30.

Ultrasound Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York; Department of Radiology, Columbia University Medical Center, New York, New York. Electronic address:

Objectives: This study sought to demonstrate the feasibility of electromechanical wave imaging (EWI) for localization of accessory pathways (AP) prior to catheter ablation in a pediatric population.

Background: Prediction of AP locations in patients with Wolff-Parkinson-White syndrome is currently based on analysis of 12-lead electrocardiography (ECG). In the pediatric population, specific algorithms have been developed to aid in localization, but these can be unreliable. Read More

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http://dx.doi.org/10.1016/j.jacep.2018.12.001DOI Listing

Natural sex change in fish.

Curr Top Dev Biol 2019 30;134:71-117. Epub 2019 Jan 30.

Department of Anatomy, University of Otago, Dunedin, New Zealand.

Sexual fate can no longer be considered an irreversible deterministic process that once established during early embryonic development, plays out unchanged across an organism's life. Rather, it appears to be a dynamic process, with sexual phenotype determined through an ongoing battle for supremacy between antagonistic male and female developmental pathways. That sexual fate is not final and is actively regulated via the suppression or activation of opposing genetic networks creates the potential for flexibility in sexual phenotype in adulthood. Read More

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http://dx.doi.org/10.1016/bs.ctdb.2018.12.014DOI Listing
January 2019

Translating genomics to the clinical diagnosis of disorders/differences of sex development.

Curr Top Dev Biol 2019 20;134:317-375. Epub 2019 Mar 20.

Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC, United States; Department of Genomics and Precision Medicine, The George Washington University, Washington, DC, United States. Electronic address:

The medical and psychosocial challenges faced by patients living with Disorders/Differences of Sex Development (DSD) and their families can be alleviated by a rapid and accurate diagnostic process. Clinical diagnosis of DSD is limited by a lack of standardization of anatomical and endocrine phenotyping and genetic testing, as well as poor genotype/phenotype correlation. Historically, DSD genes have been identified through positional cloning of disease-associated variants segregating in families and validation of candidates in animal and in vitro modeling of variant pathogenicity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00702153193000
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http://dx.doi.org/10.1016/bs.ctdb.2019.01.005DOI Listing
March 2019
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Idiopathic intracranial hypertension presenting with isolated unilateral facial nerve palsy: a case report.

J Med Case Rep 2019 Apr 19;13(1):94. Epub 2019 Apr 19.

Neurology Department, University of Minnesota, Minneapolis, MN, USA.

Background: Idiopathic intracranial hypertension, also known as pseudotumor cerebri, is a disorder characterized by increased intracranial pressure of unclear pathogenesis in the absence of other structural and obstructive lesions that is predominantly, although not exclusively, seen in obese women of childbearing age. Patients with idiopathic intracranial hypertension commonly present with a headache, transient visual obscurations, and intracranial noises with some cranial nerves occasionally involved, most commonly CN VI. We report idiopathic intracranial hypertension presenting with isolated complete unilateral facial nerve palsy, as the sole cranial nerve involved, which is a presentation rarely reported in the literature. Read More

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http://dx.doi.org/10.1186/s13256-019-2060-5DOI Listing

A Noninvasive Accurate Measurement of Blood Glucose Levels with Raman Spectroscopy of Blood in Microvessels.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

MOE Key Laboratory of Laser Life Science & Laboratory of Photonic Chinese Medicine, College of Biophotonics, South China Normal University, Guangdong 510631, China.

Raman spectra of human skin obtained by laser excitation have been used to non-invasively detect blood glucose. In previous reports, however, Raman spectra thus obtained were mainly derived from the epidermis and interstitial fluid as a result of the shallow penetration depth of lasers in skin. The physiological process by which glucose in microvessels penetrates into the interstitial fluid introduces a time delay, which inevitably introduces errors in transcutaneous measurements of blood glucose. Read More

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https://www.mdpi.com/1420-3049/24/8/1500
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http://dx.doi.org/10.3390/molecules24081500DOI Listing
April 2019
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Pattern formation of skin cancers: Effects of cancer proliferation and hydrodynamic interactions.

Phys Rev E 2019 Mar;99(3-1):032416

Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Tokyo 192-0397, Japan.

We study pattern formation of skin cancers by means of numerical simulation of a binary system consisting of cancer and healthy cells. We extend the conventional model H for macrophase separations by considering a logistic growth of cancer cells and also a mechanical friction between dermis and epidermis. Importantly, our model exhibits a microphase separation due to the proliferation of cancer cells. Read More

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http://dx.doi.org/10.1103/PhysRevE.99.032416DOI Listing

Interaction of neurotransmitters and neurochemicals with lymphocytes.

J Neuroimmunol 2019 Apr 11;332:99-111. Epub 2019 Apr 11.

The University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Brisbane, Australia; Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia. Electronic address:

Neurotransmitters and neurochemicals can act on lymphocytes by binding to receptors expressed by lymphocytes. This review describes lymphocyte expression of receptors for a selection of neurotransmitters and neurochemicals, the anatomical locations where lymphocytes can interact with neurotransmitters, and the effects of the neurotransmitters on lymphocyte function. Implications for health and disease are also discussed. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.006DOI Listing