10,629 results match your criteria Anatomia Histologia Embryologia[Journal]


Alopecia and Hypoesthesia in Folliculotropic T-Cell Lymphocytosis.

Actas Dermosifiliogr 2019 Apr 19. Epub 2019 Apr 19.

Pediatría, Centro de Salud de San Sadurniño, SERGAS, San Sadurniño, A Coruña, España.

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http://dx.doi.org/10.1016/j.ad.2018.05.015DOI Listing

Unusual histopathologic features in thymic corpuscles associated with porcine periweaning failure-to-thrive syndrome.

J Vet Diagn Invest 2019 Apr 22:1040638719846208. Epub 2019 Apr 22.

Histología y Anatomía Patológica, Facultad de Veterinaria, Universidad de Murcia, Murcia, Spain.

Six, 5-6-wk-old pigs, from 3 farms of the same company, with significant loss of body condition were submitted for postmortem evaluation. Macroscopically, the main lesion observed in all of the pigs was thymic atrophy. Microscopically, all of the pigs had thymic atrophy, superficial lymphocytic fundic gastritis, atrophic enteritis, superficial colitis, and neutrophilic and lymphocytic rhinitis, leading to a diagnosis of porcine periweaning failure-to-thrive syndrome. Read More

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http://dx.doi.org/10.1177/1040638719846208DOI Listing

Organic or conventional dairy farming in northern Spain: impacts on cow reproductive performance.

Reprod Domest Anim 2019 Apr 21. Epub 2019 Apr 21.

Universidade de Santiago de Compostela, Departamento de Patoloxía Animal, Facultade de Veterinaria, 27002, Lugo, Spain.

Organic farming has traditionally given preference to indigenous breeds that are well adapted to local conditions; however, current trends towards increased yields may produce less robust animals with potentially low fertility. The Holstein-Friesian breed dominates dairy sector, although there is a general concern that these cows may not be well adapted to organic systems. This study aims to evaluate the reproductive performance of organic dairy herds in northern Spain, by comparing organically-reared Holstein-Friesian with their counterparts reared on conventional farms and also with other organically reared breeds and crosses. Read More

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http://dx.doi.org/10.1111/rda.13446DOI Listing

CLASS I AND CLASS II SMALL LEUCINE-RICH PROTEOGLYCANS IN HUMAN CUTANEOUS PACINIAN CORPUSCLES.

Ann Anat 2019 Apr 18. Epub 2019 Apr 18.

Departamento de Morfología y Biología Celular, Grupo SINPOS Universidad de Oviedo, Spain.

Pacinian corpuscles are onion bulb-like multilayered mechanoreceptors that consist of a complicated structure of axon terminals, Schwann related cells (inner core), endoneural related cells (intermediate layer) and perineurial related cells (outer core-capsule). The cells forming those compartments are continuous and share the properties of that covering the nerve fibers. Small leucine-rich proteoglycans are major proteoglycans of the extracellular matrix and regulate collagen fibrillogenesis, cell signalling pathways and extracellular matrix assembly. Read More

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http://dx.doi.org/10.1016/j.aanat.2019.02.007DOI Listing

MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.

Biochim Biophys Acta Mol Basis Dis 2019 Apr 17. Epub 2019 Apr 17.

Scuola Superiore Sant'Anna, Institute of Life Sciences, 56124 Pisa, Italy. Electronic address:

The capacity of inducing angiogenesis is a recognized hallmark of cancer cells. The cancer microenvironment, characterized by hypoxia and inflammatory signals, promotes proliferation, migration and activation of quiescent endothelial cells (EC) from surrounding vascular network. Current anti-angiogenic drugs present side effects, temporary efficacy, and issues of primary resistance, thereby calling for the identification of new therapeutic targets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09254439193011
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http://dx.doi.org/10.1016/j.bbadis.2019.04.008DOI Listing
April 2019
1 Read

AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy.

Nat Commun 2019 Apr 18;10(1):1812. Epub 2019 Apr 18.

Laboratory of Oncology, Pangaea Oncology, Quiron Dexeus University Hospital, 08028, Barcelona, Spain.

Non-small cell lung cancer (NSCLC) tumors harboring mutations in EGFR ultimately relapse to therapy with EGFR tyrosine kinase inhibitors (EGFR TKIs). Here, we show that resistant cells without the p.T790M or other acquired mutations are sensitive to the Aurora B (AURKB) inhibitors barasertib and S49076. Read More

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http://www.nature.com/articles/s41467-019-09734-5
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http://dx.doi.org/10.1038/s41467-019-09734-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472415PMC
April 2019
1 Read

Tumors Distributed Linearly Near the Scapula in a Young Man.

Actas Dermosifiliogr 2019 Apr 15. Epub 2019 Apr 15.

Unidad de Gestión Clínica de Anatomía Patológica, Hospital Universitario Virgen Macarena, Sevilla, España.

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http://dx.doi.org/10.1016/j.ad.2018.04.012DOI Listing

Lymphangiomatosis of the ileum with perforation: A case report and review of the literature.

Ann Med Surg (Lond) 2019 May 29;41:6-10. Epub 2019 Mar 29.

Department of Surgery, University of L'Aquila, Italy.

Lymphangiomatosis is a benign proliferation of lymph vessels. Lymphatic diseases can vary from small lymphangioma to generalized lymphangiomatosis, which is a rare condition and can have several clinical manifestations. The gastrointestinal tract may be affected, but the incidence in the intestinal wall is very low. Read More

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http://dx.doi.org/10.1016/j.amsu.2019.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449703PMC

[Fast-evolving necrotic ulcer].

Aten Primaria 2019 Apr 12. Epub 2019 Apr 12.

Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.

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http://dx.doi.org/10.1016/j.aprim.2019.02.002DOI Listing

A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization.

Viruses 2019 Apr 2;11(4). Epub 2019 Apr 2.

Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz/FIOCRUZ, Rio de Janeiro 21040-900, Brazil.

Dengue virus (DENV) is an emerging virus involved in outbreaks in Brazil. The association between the virus and vertical transmission, with disorders in the placenta, has raised a worldwide concern. On the 29th gestational week, a pregnant woman presented severe complications due to a DENV infection leading to maternal and fetus death. Read More

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http://dx.doi.org/10.3390/v11040319DOI Listing

Corrigendum to "Comparison of the Proliferation and Differentiation Potential of Human Urine-, Placenta Decidua Basalis-, and Bone Marrow-Derived Stem Cells".

Stem Cells Int 2019 10;2019:1651506. Epub 2019 Mar 10.

Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610000, China.

[This corrects the article DOI: 10.1155/2018/7131532.]. Read More

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http://dx.doi.org/10.1155/2019/1651506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431511PMC

The rs17084733 variant in the KIT 3' UTR disrupts a miR-221/222 binding site in gastrointestinal stromal tumour: a sponge-like mechanism conferring disease susceptibility.

Epigenetics 2019 Apr 13:1-13. Epub 2019 Apr 13.

a Department of Pharmacy and Biotechnology , University of Bologna , Bologna , Italy.

Several miRNAs are dysregulated in gastrointestinal stromal tumours (GIST), and miR-221/222 appear to have a prominent role in GIST biology. Therefore, we investigated the role of DNA variants located in miR-221/222 precursor sequences and their target KIT 3'UTR. Ninety-five polymorphisms were analysed in 115 GIST cases and 88 healthy controls. Read More

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http://dx.doi.org/10.1080/15592294.2019.1595997DOI Listing

Metastases to the breast, an uncommon diagnosis: what do radiologists need to know?

Radiologia 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Objective: To analyze the imaging characteristics of histologically diagnosed metastases to the breast.

Material And Methods: We selected patients histologically diagnosed with metastases to the breast in our diagnostic and interventional breast imaging unit between March 2010 and September 2018.

Results: A total of 9 patients (all women; mean age, 60 y; age range, 28-89 y) were diagnosed with metastases to the breast. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00338338193003
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http://dx.doi.org/10.1016/j.rx.2019.02.004DOI Listing
April 2019
2 Reads

TGFβ2-induced senescence during early inner ear development.

Sci Rep 2019 Apr 11;9(1):5912. Epub 2019 Apr 11.

Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), Madrid, Spain.

Embryonic development requires the coordinated regulation of apoptosis, survival, autophagy, proliferation and differentiation programs. Senescence has recently joined the cellular processes required to master development, in addition to its well-described roles in cancer and ageing. Here, we show that senescent cells are present in a highly regulated temporal pattern in the developing vertebrate inner ear, first, surrounding the otic pore and, later, in the otocyst at the endolymphatic duct. Read More

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http://www.nature.com/articles/s41598-019-42040-0
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http://dx.doi.org/10.1038/s41598-019-42040-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459823PMC
April 2019
1 Read

[Analysis of solid ovarian tumours in a Spanish paediatric population].

An Pediatr (Barc) 2019 Apr 8. Epub 2019 Apr 8.

UGC Cirugía Pediátrica, Hospital Universitario Reina Sofía, Córdoba, España.

Introduction And Objectives: Ovarian tumours are rare in childhood, and account for 1-5% of all tumours. The aim of this study is to determine the epidemiological features, histological subtypes, and therapeutic management of ovarian solid ovarian tumours of the paediatric population of the province of Cordoba, in Spain.

Material And Methods: A retrospective, descriptive, observational and institutional study was conducted in which a review was made of the clinical histories of patients younger than 14years-old diagnosed with ovarian tumours, excluding secondary tumours in a University Hospital between 1994 and 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16954033193007
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http://dx.doi.org/10.1016/j.anpedi.2019.02.002DOI Listing
April 2019
2 Reads

Reply.

Reumatol Clin 2019 Apr 7. Epub 2019 Apr 7.

Servicio de Reumatología, Complexo Hospitalario Universitario de A Coruña, A Coruña, España.

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http://dx.doi.org/10.1016/j.reuma.2019.01.005DOI Listing

Comprehensive clinical, molecular and histopathological analysis of bone marrow in chronic myeloproliferative neoplasia.

Rev Clin Esp 2019 Apr 7. Epub 2019 Apr 7.

Servicio de Hematología y Hemoterapia, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, España.

Objectives: To analyse the possible correlation between molecular changes in the JAK2, MPL and CALR genes, the morphological pattern of bone marrow and the clinical-haematologic profile of patients.

Patients And Methods: We conducted a retrospective study that included 140 patients diagnosed with Philadelphia-negative myeloproliferative neoplasia (Ph-MPN) in a single centre.

Results: In essential thrombocythaemia (ET), the patients with the JAK2 V617F mutation presented more leucocytes and neutrophils than patients who presented the CALR mutation, who had more platelets and a greater need for cytoreductive therapy. Read More

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http://dx.doi.org/10.1016/j.rce.2018.11.012DOI Listing
April 2019
1 Read

Molluscum Contagiosum on the Palms: An Uncommon Location.

Actas Dermosifiliogr 2019 Apr 7. Epub 2019 Apr 7.

Hospital Dermatológico Internacional, Madrid, España.

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http://dx.doi.org/10.1016/j.ad.2018.02.043DOI Listing

Tree Circumference Changes and Species-Specific Growth Recovery After Extreme Dry Events in a Montane Rainforest in Southern Ecuador.

Front Plant Sci 2019 22;10:342. Epub 2019 Mar 22.

Institute of Geography, Friedrich Alexander University Erlangen-Nürnberg, Nuremberg, Germany.

Under drought conditions, even tropical rainforests might turn from carbon sinks to sources, and tree species composition might be altered by increased mortality. We monitored stem diameter variations of 40 tree individuals with stem diameters above 10 cm belonging to eleven different tree genera and three tree life forms with high-resolution dendrometers from July 2007 to November 2010 and additionally March 2015 to December 2017 in a tropical mountain rainforest in South Ecuador, a biodiversity hotspot with more than 300 different tree species belonging to different functional types. Although our study area receives around 2200 mm of annual rainfall, dry spells occur regularly during so-called "Veranillo del Niño" (VdN) periods in October-November. Read More

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http://dx.doi.org/10.3389/fpls.2019.00342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439692PMC

Class 1, 2 and 3 BRAF mutated metastatic colorectal cancer: a detailed clinical, pathological and molecular characterization.

Clin Cancer Res 2019 Apr 9. Epub 2019 Apr 9.

Department of Medicine, University of Padua.

Purpose BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1 - V600E) or as dimers (class 2 - codons 597/601), and RAS-dependent with impaired kinase activity (class 3 - codons 594/596). While clinical, pathological and molecular features of V600E BRAF mutated metastatic colorectal cancer (mCRC) are well known, limited data are available from the two other classes. Experimental Design Data from 117 BRAF (92 class 1, 12 class 2, and 13 class 3) mutated mCRC patients were collected. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-19-0311DOI Listing
April 2019
3 Reads

Diffractive and Interferometric Characterization of Nanostructured Photopolymer for Sharp Diffractive Optical Elements Recording.

Polymers (Basel) 2018 May 10;10(5). Epub 2018 May 10.

Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante, P.O. Box 99, E-03080 Alicante, Spain.

We study the behavior of a nanoparticle-polymer composite (NPC) material, based on a thiol-ene monomer system, working with long grating spacing. Thus, we evaluate the suitability of the NPC for storing complex diffractive optical elements with sharp profiles, such as blazed gratings. Using holographic methods, we measure the "apparent" diffusion of the material and the influence of the spatial period on this diffusion. Read More

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http://dx.doi.org/10.3390/polym10050518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415438PMC

Numerical Analysis of H-PDLC Using the Split-Field Finite-Difference Time-Domain Method.

Polymers (Basel) 2018 Apr 24;10(5). Epub 2018 Apr 24.

Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante, P.O. Box 99, E-03080 Alicante, Spain.

In this work, an accurate numerical modeling of the diffraction properties of transmission holographic polymer dispersed liquid crystal (H-PDLC) gratings is presented. The method considers ellipsoid geometry-based liquid crystal (LC) droplets with random properties regarding size and location across the H-PLDC layer and also the non-homogeneous orientation of the LC director within the droplet. The direction of the LC director inside the droplets can be varied to reproduce the effects of the external voltage applied in H-PDLC-based gratings. Read More

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http://dx.doi.org/10.3390/polym10050465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415371PMC

Holographic Lenses in an Environment-Friendly Photopolymer.

Polymers (Basel) 2018 Mar 11;10(3). Epub 2018 Mar 11.

Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante, Apartado de correos 99, Alicante E-03080, Spain.

In this paper, we theoretically and experimentally evaluated the quality of volume phase transmission lenses stored in an environmentally friendly photopolymer. Holographic lenses (HLs) were obtained using symmetrical and asymmetrical experimental setups with the same positive and negative focal length and pupil diameter. The image quality was evaluated from the calculation of the modulation transfer function (MTF) by capturing the point spread function (PSF) with a charge-coupled device (CCD). Read More

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http://dx.doi.org/10.3390/polym10030302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414980PMC

Mesoporous bioactive glass/ɛ-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep.

Acta Biomater 2019 Apr 6. Epub 2019 Apr 6.

Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Spain. Electronic address:

Macroporous scaffolds made of a SiO-CaO-PO mesoporous bioactive glass (MBG) and ɛ-polycaprolactone (PCL) have been prepared by robocasting. These scaffolds showed an excellent in vitro biocompatibility in contact with osteoblast like cells (Saos 2) and osteoclasts derived from RAW 264.7 macrophages. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.019DOI Listing
April 2019
3 Reads

Gastric serrated adenoma.

Rev Esp Enferm Dig 2019 Apr 9. Epub 2019 Apr 9.

Servicio de Anatomía Patológica, Hospital Costa del Sol, España.

A 51 years-old male with several family history of gastric cancer, who was studied one year before for dyspepsia. A new gastroscopy was done that objectified in the greater curvature, a sessile polyp with slightly depressed center and a villous crypt pattern with Narrow Band Imaging. The histopathology study shown a horizontalization of the basal glands and basal dysplasia, compatible with serrated adenoma. Read More

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http://dx.doi.org/10.17235/reed.2019.6145/2018DOI Listing

Diagnosis and Treatment of Merkel Cell Carcinoma in Specialized Dermatology Units: A Clinical Practice Guideline of the Spanish Academy of Dermatology and Venereology.

Actas Dermosifiliogr 2019 Apr 5. Epub 2019 Apr 5.

Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.

Background And Objective: Merkel cell carcinoma is a rare, aggressive skin cancer that is managed in a great variety of ways. However, international clinical practice guidelines give only partial coverage to issues considered major problems.The recommendations presented here aim to provide Spanish dermatologists with a guide to improving disputed aspects of diagnosis, staging, and treatment of localized Merkel cell carcinomas. Read More

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http://dx.doi.org/10.1016/j.ad.2019.01.006DOI Listing
April 2019
2 Reads

Holographic Characteristics of Photopolymers Containing Different Mixtures of Nematic Liquid Crystals.

Polymers (Basel) 2019 Feb 13;11(2). Epub 2019 Feb 13.

Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante, Apartado 99, E03080 Alicante, Spain.

A holographic polymer dispersed liquid crystal (HPDLC) is used to record holographic diffraction gratings. Several mixtures of nematic liquid crystals (LC) are used as components of the HPDLC to evaluate their influence in static and dynamic basic properties. The diffraction efficiency obtained in the reconstruction of the holograms is evaluated to compare the influence of the different LC. Read More

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http://dx.doi.org/10.3390/polym11020325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419176PMC
February 2019

Influence of Tert-Butylthiol and Tetrahydrofuran on the Holographic Characteristics of a Polymer Dispersed Liquid Crystal: A Research Line Toward a Specific Sensor for Natural Gas and Liquefied Petroleum Gas.

Polymers (Basel) 2019 Feb 2;11(2). Epub 2019 Feb 2.

Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante, Apartado 99, 03080 Alicante, Spain.

Tert-Butylthiol (TBT) and tetrahydrothiophene (THT) are odorant substances added to natural gas and liquefied petroleum gas to help their detection by the human smell. In this research, TBT and THT are incorporated into a holographic polymer-dispersed liquid crystal and their influence in the main holographic characteristics of the photopolymer are studied in order to open the way towards the design of a holographic sensor to detect natural gas and liquefied petroleum gas. Read More

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http://dx.doi.org/10.3390/polym11020254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419087PMC
February 2019

LED-Cured Reflection Gratings Stored in an Acrylate-Based Photopolymer.

Polymers (Basel) 2019 Apr 6;11(4). Epub 2019 Apr 6.

Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante, Apartado de correos 99, Alicante E-03080, Spain.

The storage of volume holographic reflection gratings in low-toxicity photopolymers represents a challenge at present since they can be used in many important applications such as biosensors and holographic optical elements. In this context, an acrylate-based photopolymer developed in our research group was employed to study the recording of unslanted holographic reflection gratings at high spatial frequencies. The optimal preparation conditions of the photopolymer layers were determinated. Read More

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http://dx.doi.org/10.3390/polym11040632DOI Listing

Clinical-pathological characteristics and short-term follow-up associated with proliferation, apoptosis and angiogenesis in a prospective cohort of patients with colorectal tumours.

Tumour Biol 2019 Apr;42(4):1010428319835684

1 Unidad de Investigación, Hospital Costa del Sol, REDISSEC, Marbella, España.

We investigate the clinical and pathological features related to variations in colorectal tumour apoptosis, proliferation and angiogenesis and the influence of the latter in short-term mortality (2 years); 551 tumour samples from a prospective cohort of patients with colorectal cancer were examined and tumour biology markers were determined as follows: percentage of apoptotic cells, by the terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling technique; Ki-67 antigen, as a cell proliferation marker and density of microvessels (as a marker of angiogenesis). An increase in the percentage of cellular apoptosis is significantly related to the presence of poorly differentiated tumours, with vascular invasion (p < 0.001). Read More

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http://dx.doi.org/10.1177/1010428319835684DOI Listing

Comment to: "small for gestational age infants and the association with placental and umbilical cord morphometry: a digital imaging study".

J Matern Fetal Neonatal Med 2019 Apr 18:1-2. Epub 2019 Apr 18.

c Area of Pathology, Department of Woman, Child Health and Public Health , Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Istituto di Anatomia Patologica, Università Cattolica del Sacro Cuore , Rome , Italy.

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http://dx.doi.org/10.1080/14767058.2019.1604664DOI Listing

Response Adaptation in Barrel Cortical Neurons Facilitates Stimulus Detection during Rhythmic Whisker Stimulation in Anesthetized Mice.

eNeuro 2019 Mar-Apr;6(2). Epub 2019 Apr 2.

Departamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid 28029, Spain.

Rodents use rhythmic whisker movements at frequencies between 4 and 12 Hz to sense the environment that will be disturbed when the animal touches an object. The aim of this work is to study the response adaptation to rhythmic whisker stimulation trains at 4 Hz in the barrel cortex and the sensitivity of cortical neurons to changes in the timing of the stimulation pattern. Longitudinal arrays of four iridium oxide electrodes were used to obtain single-unit recordings in supragranular, granular, and infragranular neurons in urethane anesthetized mice. Read More

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http://dx.doi.org/10.1523/ENEURO.0471-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449164PMC

Characterization of Mycoplasma hyopneumoniae strains in vaccinated and non-vaccinated pigs from Spanish slaughterhouses.

Vet Microbiol 2019 Apr 20;231:18-23. Epub 2019 Feb 20.

IRTA, Centre de Recerca en Sanitat Animal (CRESA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. Electronic address:

This study aimed to describe Mycoplasma hyopneumoniae (M. hyopneumoniae) genetic variability in vaccinated (V) and non-vaccinated (NV) slaughtered pigs showing cranio-ventral pulmonary consolidation (CVPC). Ten V and 10 NV fattening farms with respiratory problems associated to M. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.02.023DOI Listing
April 2019
1 Read

Intussusception reveals MUTYH-associated polyposis syndrome and colorectal cancer: a case report.

BMC Cancer 2019 Apr 5;19(1):324. Epub 2019 Apr 5.

Diretor do Departamento de Patologia Clínica e Anatomia Patológica do Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: We are reporting a rare case of MUTYH-associated polyposis, a colorectal cancer hereditary syndrome, diagnosticated after an intussusception. Colorectal cancer is an important cause of cancer related mortality that can be manifested by an intussusception, a rare occurrence in adults and almost always related to tumors. Approximately 5% of colorectal cancers can be attributed to syndromes known to cause hereditary colorectal cancer, such as MUTYH-associated polyposis, autosomal genetic syndrome associated with this disease. Read More

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http://dx.doi.org/10.1186/s12885-019-5505-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451307PMC
April 2019
1 Read

Longevity and cause of death in male Wistar rats fed lifelong diets based on virgin olive oil, sunflower oil or fish oil.

J Gerontol A Biol Sci Med Sci 2019 Apr 6. Epub 2019 Apr 6.

Department of Physiology, Institute of Nutrition and Food Technology "Jose Mataix", Biomedical Research Center, University of Granada, Avda. Conocimiento s/n, Armilla, Granada, Spain.

Extending life by delaying the aging process have proven to be the most effective way to fight multiple chronic diseases in elderly adults. Evidence suggests that longevity is inversely related to unsaturation of membrane phospholipids. The present study investigated how different unsaturated dietary fats affect lifespan and cause death in male Wistar rats fed diets based on virgin olive oil (V), sunflower oil (S) or fish oil (F), which were supplemented or not with Coenzyme Q10 (CoQ10). Read More

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http://dx.doi.org/10.1093/gerona/glz091DOI Listing

Corrigendum: Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot () Enteromyxosis.

Front Genet 2019 20;10:225. Epub 2019 Mar 20.

Departamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Universidade de Santiago de Compostela, Lugo, Spain.

[This corrects the article DOI: 10.3389/fgene.2019. Read More

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http://dx.doi.org/10.3389/fgene.2019.00225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436033PMC

Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis.

World J Gastroenterol 2019 Mar;25(12):1465-1477

Istituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, Roma 00168, Italy.

Background: Anti-tumor necrosis factor α (TNFα) represents the best therapeutic option to induce mucosal healing and clinical remission in patients with moderate-severe ulcerative colitis. On the other side gut microbiota plays a crucial role in pathogenesis of ulcerative colitis but few information exists on how microbiota changes following anti-TNFα therapy and on microbiota role in mucosal healing.

Aim: To elucidate whether gut microbiota and immune system changes appear following anti TNFα therapy during dextran sulfate sodium (DSS) colitis. Read More

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http://dx.doi.org/10.3748/wjg.v25.i12.1465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441917PMC
March 2019
1 Read

WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.

Nat Commun 2019 04 2;10(1):1498. Epub 2019 Apr 2.

Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, 62500, Czech Republic.

WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) of the developing hindbrain, but not the telencephalon, in both mouse and human. Read More

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http://dx.doi.org/10.1038/s41467-019-09298-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445127PMC
April 2019
3 Reads

Antitumoral Effect of Laurinterol on 3D Culture of Breast Cancer Explants.

Mar Drugs 2019 Mar 29;17(4). Epub 2019 Mar 29.

División de Investigación en Salud, Unidad Médica de Alta Especialidad, Hospital de Cardiología No. 34, Instituto Mexicano del Seguro Social (IMSS), Av. Lincoln S/N esquina con Enfermera María de Jesús Candia, Col. Valle Verde 2do. Sector, 64360 Monterrey, Nuevo León, México.

Macroalgae represent an important source of bioactive compounds with a wide range of biotechnological applications. Overall, the discovery of effective cytotoxic compounds with pharmaceutical potential is a significant challenge, mostly because they are scarce in nature or their total synthesis is not efficient, while the bioprospecting models currently used do not predict clinical responses. Given this context, we used three-dimensional (3D) cultures of human breast cancer explants to evaluate the antitumoral effect of laurinterol, the major compound of an ethanolic extract of . Read More

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http://dx.doi.org/10.3390/md17040201DOI Listing

Enrofloxacin and Roundup interactive effects on the aquatic macrophyte Elodea canadensis physiology.

Environ Pollut 2019 Mar 11;249:453-462. Epub 2019 Mar 11.

Ecotoxicology of Aquatic Microorganisms Laboratory, GRIL, TOXEN, Department of Biological Sciences, Université du Québec à Montréal, Montréal Succ. Centre-Ville, H3C 3P8, Montréal, QC, Canada.

The co-occurrence of aquatic contaminants, such as antibiotics and herbicides, has motivated investigations into their interactive effects on aquatic organisms. We examined the combined effects of environmental concentrations of the antibiotic Enrofloxacin (Enro; 0-2.25 μg l) and Roundup Original (Roundup; 0-0. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.026DOI Listing

Ageing of the somatosensory system at the periphery: age-related changes in cutaneous mechanoreceptors.

J Anat 2019 Mar 29. Epub 2019 Mar 29.

Departamento de Morfología y Biología Celular, Grupo SINPOS Universidad de Oviedo, Oviedo, Spain.

Decline of tactile sensation associated with ageing depends on modifications in skin and both central and peripheral nervous systems. At present, age-related changes in the periphery of the somatosensory system, particularly concerning the effects on mechanoreceptors, remain unknown. Here we used immunohistochemistry to analyse the age-dependent changes in Meissner's and Pacinian corpuscles as well as in Merkel cell-neurite complexes. Read More

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http://dx.doi.org/10.1111/joa.12983DOI Listing
March 2019
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Report Standardization in Transbronchial Lung Cryobiopsy.

Arch Pathol Lab Med 2019 Apr;143(4):416-417

1  Department of Diseases of the Thorax (Drs Ravaglia, Tomassetti, and Poletti), G.B. Morgagni - L. Pierantoni Hospital, Forlì, Italy.

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http://dx.doi.org/10.5858/arpa.2018-0438-LEDOI Listing

A novel ABCA12 pathologic variant identified in an Ecuadorian harlequin ichthyosis patient: A step forward in genotype-phenotype correlations.

Mol Genet Genomic Med 2019 Mar 27:e608. Epub 2019 Mar 27.

Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela, Spain.

Background: Autosomal recessive congenital ichthyoses (ARCI) have been associated with different phenotypes including: harlequin ichthyosis (HI), congenital ichthyosiform erythroderma (CIE), and lamellar ichthyosis (LI). While pathogenic variants in all ARCI genes are associated with LI and CIE phenotypes, the unique gene associated with HI is ABCA12. In HI, the most severe ARCI form, pathogenic variants in both ABCA12 gene alleles usually have a severe impact on protein function. Read More

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http://dx.doi.org/10.1002/mgg3.608DOI Listing

ER-/PR+/HER2- breast cancer type shows the highest proliferative activity among all other combined phenotypes and is more common in young patients: Experience with 6643 breast cancer cases.

Breast J 2019 Mar 27. Epub 2019 Mar 27.

Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Anatomia Patologica, Università Cattolica del Sacro Cuore, Rome, Italy.

The characterization of breast cancer according to its proliferative activity and the expression of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor-2 is a laboratory routine that has been adopted worldwide for prognostic and therapeutic purposes. By combining data on the expression of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor-2, it is possible to obtain 8 tumor patterns categorized as triple-negative, nonluminal (i.e. Read More

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http://dx.doi.org/10.1111/tbj.13236DOI Listing
March 2019
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Brimonidine-induced unilateral ocular lichen planus: a case report.

Arq Bras Oftalmol 2019 Mar 25. Epub 2019 Mar 25.

Servicio de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain.

This report was written to describe a case of unilateral brimonidine-induced conjunctival lichen planus. Because the ophthalmic examination indicated chronic conjunctivitis or drug-induced pseudopemphigoid, the patient underwent thorough ophthalmic and systemic examinations, as well as conjunctival biopsy and direct immunofluorescence studies. A 71-year-old woman with unilateral left eye findings of chronic conjunctivitis was referred to our Ophthalmology Department. Read More

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http://dx.doi.org/10.5935/0004-2749.20190047DOI Listing

Association between BRAF (V600E) mutation and clinicopathological features of papillary thyroid carcinoma: a Brazilian single-centre case series.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Departamento de Biorregulação, Laboratório de Estudo da Tireoide, Instituto de Saúde e Ciência, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil.

Objectives: We aimed to investigate the prevalence of the BRAF (V600E) mutation in consecutive cases of papillary thyroid carcinoma (PTC) in patients diagnosed and treated at the Hospital Sao Rafael (Salvador, BA, Brazil) and evaluate its association with clinical and pathological characteristics of PTC.

Subjects And Methods: We retrospectively enrolled in the study a total of 43 consecutive PTC patients who underwent total thyroidectomy. We performed DNA extraction from formalin-fixed paraffin-embedded (FFPE) tumour tissue samples. Read More

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http://dx.doi.org/10.20945/2359-3997000000120DOI Listing
March 2019
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Aganglionic megacolon in the adult. Urgent and surprising cause of intestinal occlusion.

Rev Esp Enferm Dig 2019 Mar 26;111. Epub 2019 Mar 26.

Cirugía General y del Aparato Digestivo, Hospital Universitario de Gran Canaria Dr. Negrín.

In relation to the interesting article published recently in your scientific journal titled "Hirschsprung disease with debut in adult age as acute intestinal obstruction: a case report" , we would like to provide an exceptional case where the evolution of Hirschsprung's disease and an infrequent surgical complication developed in the long term are combined. Read More

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http://dx.doi.org/10.17235/reed.2019.5922/2018DOI Listing
March 2019
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Minimally-invasive treatments for benign thyroid nodules: a Delphi-based consensus statement from the Italian minimally-invasive treatments of the thyroid (MITT) group.

Int J Hyperthermia 2019 26;36(1):376-382. Epub 2019 Mar 26.

aa Division of Interventional Radiology , IEO, European Institute of Oncology IRCCS , Milan , Italy.

Benign thyroid nodules are a common clinical occurrence and usually do not require treatment unless symptomatic. During the last years, ultrasound-guided minimally invasive treatments (MIT) gained an increasing role in the management of nodules causing local symptoms. In February 2018, the Italian MIT Thyroid Group was founded to create a permanent cooperation between Italian and international physicians dedicated to clinical research and assistance on MIT for thyroid nodules. Read More

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http://dx.doi.org/10.1080/02656736.2019.1575482DOI Listing
March 2019
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Breeding for organic dairy farming: what types of cows are needed?

J Dairy Res 2019 Feb;86(1):3-12

Departamento de Patoloxía Animal, Facultade de Veterinaria,Universidade de Santiago de Compostela,27002 Lugo,Spain.

Organic farming is believed by many to be an environmentally friendly production system that promotes the use of local forage while strongly limiting the input of chemicals, including allopathic treatments. As organic dairy farming has grown, farmers have realised that many available conventional breeds of cow are not well adapted to the new situations and that more 'robust' cows, able to function well in the constraining organic environment, are needed to yield acceptable longevity and productivity. In this review paper, the current breed diversity in organic dairy farming is analysed with the aim of identifying the types of cow that would best fulfil organic breeding goals. Read More

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https://www.cambridge.org/core/product/identifier/S002202991
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http://dx.doi.org/10.1017/S0022029919000141DOI Listing
February 2019
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Diagnostic yield of magnetic resonance imaging and intraoperative frozen section in the determination of deep myometrial invasion in endometrial cancer.

Radiologia 2019 Mar 21. Epub 2019 Mar 21.

Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Background And Objectives: The standard treatment for endometrial cancer is simple hysterectomy with bilateral salpingo-oophorectomy. Patients with high risk also benefit from lumbo-aortic lymphadenectomy. High risk patients include those with grades and histologic subtypes associated with poor prognosis and depth of myometrial invasion greater than 50% (M2). Read More

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http://dx.doi.org/10.1016/j.rx.2019.01.007DOI Listing
March 2019
1 Read