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Actas Dermosifiliogr 2019 Apr 19. Epub 2019 Apr 19.

Pediatría, Centro de Salud de San Sadurniño, SERGAS, San Sadurniño, A Coruña, España.

J Vet Diagn Invest 2019 Apr 22:1040638719846208. Epub 2019 Apr 22.

Histología y Anatomía Patológica, Facultad de Veterinaria, Universidad de Murcia, Murcia, Spain.

Six, 5-6-wk-old pigs, from 3 farms of the same company, with significant loss of body condition were submitted for postmortem evaluation. Macroscopically, the main lesion observed in all of the pigs was thymic atrophy. Microscopically, all of the pigs had thymic atrophy, superficial lymphocytic fundic gastritis, atrophic enteritis, superficial colitis, and neutrophilic and lymphocytic rhinitis, leading to a diagnosis of porcine periweaning failure-to-thrive syndrome. Read More

Reprod Domest Anim 2019 Apr 21. Epub 2019 Apr 21.

Universidade de Santiago de Compostela, Departamento de Patoloxía Animal, Facultade de Veterinaria, 27002, Lugo, Spain.

Organic farming has traditionally given preference to indigenous breeds that are well adapted to local conditions; however, current trends towards increased yields may produce less robust animals with potentially low fertility. The Holstein-Friesian breed dominates dairy sector, although there is a general concern that these cows may not be well adapted to organic systems. This study aims to evaluate the reproductive performance of organic dairy herds in northern Spain, by comparing organically-reared Holstein-Friesian with their counterparts reared on conventional farms and also with other organically reared breeds and crosses. Read More

Ann Anat 2019 Apr 18. Epub 2019 Apr 18.

Departamento de Morfología y Biología Celular, Grupo SINPOS Universidad de Oviedo, Spain.

Pacinian corpuscles are onion bulb-like multilayered mechanoreceptors that consist of a complicated structure of axon terminals, Schwann related cells (inner core), endoneural related cells (intermediate layer) and perineurial related cells (outer core-capsule). The cells forming those compartments are continuous and share the properties of that covering the nerve fibers. Small leucine-rich proteoglycans are major proteoglycans of the extracellular matrix and regulate collagen fibrillogenesis, cell signalling pathways and extracellular matrix assembly. Read More

Biochim Biophys Acta Mol Basis Dis 2019 Apr 17. Epub 2019 Apr 17.

Scuola Superiore Sant'Anna, Institute of Life Sciences, 56124 Pisa, Italy. Electronic address:

The capacity of inducing angiogenesis is a recognized hallmark of cancer cells. The cancer microenvironment, characterized by hypoxia and inflammatory signals, promotes proliferation, migration and activation of quiescent endothelial cells (EC) from surrounding vascular network. Current anti-angiogenic drugs present side effects, temporary efficacy, and issues of primary resistance, thereby calling for the identification of new therapeutic targets. Read More

Nat Commun 2019 Apr 18;10(1):1812. Epub 2019 Apr 18.

Laboratory of Oncology, Pangaea Oncology, Quiron Dexeus University Hospital, 08028, Barcelona, Spain.

Non-small cell lung cancer (NSCLC) tumors harboring mutations in EGFR ultimately relapse to therapy with EGFR tyrosine kinase inhibitors (EGFR TKIs). Here, we show that resistant cells without the p.T790M or other acquired mutations are sensitive to the Aurora B (AURKB) inhibitors barasertib and S49076. Read More

Actas Dermosifiliogr 2019 Apr 15. Epub 2019 Apr 15.

Unidad de Gestión Clínica de Anatomía Patológica, Hospital Universitario Virgen Macarena, Sevilla, España.

Ann Med Surg (Lond) 2019 May 29;41:6-10. Epub 2019 Mar 29.

Department of Surgery, University of L'Aquila, Italy.

Lymphangiomatosis is a benign proliferation of lymph vessels. Lymphatic diseases can vary from small lymphangioma to generalized lymphangiomatosis, which is a rare condition and can have several clinical manifestations. The gastrointestinal tract may be affected, but the incidence in the intestinal wall is very low. Read More

Aten Primaria 2019 Apr 12. Epub 2019 Apr 12.

Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.

Viruses 2019 Apr 2;11(4). Epub 2019 Apr 2.

Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz/FIOCRUZ, Rio de Janeiro 21040-900, Brazil.

Dengue virus (DENV) is an emerging virus involved in outbreaks in Brazil. The association between the virus and vertical transmission, with disorders in the placenta, has raised a worldwide concern. On the 29th gestational week, a pregnant woman presented severe complications due to a DENV infection leading to maternal and fetus death. Read More

Stem Cells Int 2019 10;2019:1651506. Epub 2019 Mar 10.

Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610000, China.

[This corrects the article DOI: 10.1155/2018/7131532.]. Read More

Epigenetics 2019 Apr 13:1-13. Epub 2019 Apr 13.

a Department of Pharmacy and Biotechnology , University of Bologna , Bologna , Italy.

Several miRNAs are dysregulated in gastrointestinal stromal tumours (GIST), and miR-221/222 appear to have a prominent role in GIST biology. Therefore, we investigated the role of DNA variants located in miR-221/222 precursor sequences and their target KIT 3'UTR. Ninety-five polymorphisms were analysed in 115 GIST cases and 88 healthy controls. Read More

Radiologia 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Objective: To analyze the imaging characteristics of histologically diagnosed metastases to the breast.

Material And Methods: We selected patients histologically diagnosed with metastases to the breast in our diagnostic and interventional breast imaging unit between March 2010 and September 2018.

Results: A total of 9 patients (all women; mean age, 60 y; age range, 28-89 y) were diagnosed with metastases to the breast. Read More

Sci Rep 2019 Apr 11;9(1):5912. Epub 2019 Apr 11.

Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), Madrid, Spain.

Embryonic development requires the coordinated regulation of apoptosis, survival, autophagy, proliferation and differentiation programs. Senescence has recently joined the cellular processes required to master development, in addition to its well-described roles in cancer and ageing. Here, we show that senescent cells are present in a highly regulated temporal pattern in the developing vertebrate inner ear, first, surrounding the otic pore and, later, in the otocyst at the endolymphatic duct. Read More

An Pediatr (Barc) 2019 Apr 8. Epub 2019 Apr 8.

UGC Cirugía Pediátrica, Hospital Universitario Reina Sofía, Córdoba, España.

Introduction And Objectives: Ovarian tumours are rare in childhood, and account for 1-5% of all tumours. The aim of this study is to determine the epidemiological features, histological subtypes, and therapeutic management of ovarian solid ovarian tumours of the paediatric population of the province of Cordoba, in Spain.

Material And Methods: A retrospective, descriptive, observational and institutional study was conducted in which a review was made of the clinical histories of patients younger than 14years-old diagnosed with ovarian tumours, excluding secondary tumours in a University Hospital between 1994 and 2017. Read More

Reumatol Clin 2019 Apr 7. Epub 2019 Apr 7.

Servicio de Reumatología, Complexo Hospitalario Universitario de A Coruña, A Coruña, España.

Rev Clin Esp 2019 Apr 7. Epub 2019 Apr 7.

Servicio de Hematología y Hemoterapia, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, España.

Objectives: To analyse the possible correlation between molecular changes in the JAK2, MPL and CALR genes, the morphological pattern of bone marrow and the clinical-haematologic profile of patients.

Patients And Methods: We conducted a retrospective study that included 140 patients diagnosed with Philadelphia-negative myeloproliferative neoplasia (Ph-MPN) in a single centre.

Results: In essential thrombocythaemia (ET), the patients with the JAK2 V617F mutation presented more leucocytes and neutrophils than patients who presented the CALR mutation, who had more platelets and a greater need for cytoreductive therapy. Read More

Actas Dermosifiliogr 2019 Apr 7. Epub 2019 Apr 7.

Hospital Dermatológico Internacional, Madrid, España.

Front Plant Sci 2019 22;10:342. Epub 2019 Mar 22.

Institute of Geography, Friedrich Alexander University Erlangen-Nürnberg, Nuremberg, Germany.

Under drought conditions, even tropical rainforests might turn from carbon sinks to sources, and tree species composition might be altered by increased mortality. We monitored stem diameter variations of 40 tree individuals with stem diameters above 10 cm belonging to eleven different tree genera and three tree life forms with high-resolution dendrometers from July 2007 to November 2010 and additionally March 2015 to December 2017 in a tropical mountain rainforest in South Ecuador, a biodiversity hotspot with more than 300 different tree species belonging to different functional types. Although our study area receives around 2200 mm of annual rainfall, dry spells occur regularly during so-called "Veranillo del Niño" (VdN) periods in October-November. Read More

Clin Cancer Res 2019 Apr 9. Epub 2019 Apr 9.

Department of Medicine, University of Padua.

Purpose BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1 - V600E) or as dimers (class 2 - codons 597/601), and RAS-dependent with impaired kinase activity (class 3 - codons 594/596). While clinical, pathological and molecular features of V600E BRAF mutated metastatic colorectal cancer (mCRC) are well known, limited data are available from the two other classes. Experimental Design Data from 117 BRAF (92 class 1, 12 class 2, and 13 class 3) mutated mCRC patients were collected. Read More

Polymers (Basel) 2018 May 10;10(5). Epub 2018 May 10.

Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante, P.O. Box 99, E-03080 Alicante, Spain.

We study the behavior of a nanoparticle-polymer composite (NPC) material, based on a thiol-ene monomer system, working with long grating spacing. Thus, we evaluate the suitability of the NPC for storing complex diffractive optical elements with sharp profiles, such as blazed gratings. Using holographic methods, we measure the "apparent" diffusion of the material and the influence of the spatial period on this diffusion. Read More

Polymers (Basel) 2018 Apr 24;10(5). Epub 2018 Apr 24.

Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante, P.O. Box 99, E-03080 Alicante, Spain.

In this work, an accurate numerical modeling of the diffraction properties of transmission holographic polymer dispersed liquid crystal (H-PDLC) gratings is presented. The method considers ellipsoid geometry-based liquid crystal (LC) droplets with random properties regarding size and location across the H-PLDC layer and also the non-homogeneous orientation of the LC director within the droplet. The direction of the LC director inside the droplets can be varied to reproduce the effects of the external voltage applied in H-PDLC-based gratings. Read More

Polymers (Basel) 2018 Mar 11;10(3). Epub 2018 Mar 11.

Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante, Apartado de correos 99, Alicante E-03080, Spain.

In this paper, we theoretically and experimentally evaluated the quality of volume phase transmission lenses stored in an environmentally friendly photopolymer. Holographic lenses (HLs) were obtained using symmetrical and asymmetrical experimental setups with the same positive and negative focal length and pupil diameter. The image quality was evaluated from the calculation of the modulation transfer function (MTF) by capturing the point spread function (PSF) with a charge-coupled device (CCD). Read More

Acta Biomater 2019 Apr 6. Epub 2019 Apr 6.

Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Spain. Electronic address:

Macroporous scaffolds made of a SiO-CaO-PO mesoporous bioactive glass (MBG) and ɛ-polycaprolactone (PCL) have been prepared by robocasting. These scaffolds showed an excellent in vitro biocompatibility in contact with osteoblast like cells (Saos 2) and osteoclasts derived from RAW 264.7 macrophages. Read More

Rev Esp Enferm Dig 2019 Apr 9. Epub 2019 Apr 9.

Servicio de Anatomía Patológica, Hospital Costa del Sol, España.

A 51 years-old male with several family history of gastric cancer, who was studied one year before for dyspepsia. A new gastroscopy was done that objectified in the greater curvature, a sessile polyp with slightly depressed center and a villous crypt pattern with Narrow Band Imaging. The histopathology study shown a horizontalization of the basal glands and basal dysplasia, compatible with serrated adenoma. Read More

Actas Dermosifiliogr 2019 Apr 5. Epub 2019 Apr 5.

Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.

Background And Objective: Merkel cell carcinoma is a rare, aggressive skin cancer that is managed in a great variety of ways. However, international clinical practice guidelines give only partial coverage to issues considered major problems.The recommendations presented here aim to provide Spanish dermatologists with a guide to improving disputed aspects of diagnosis, staging, and treatment of localized Merkel cell carcinomas. Read More

Polymers (Basel) 2019 Feb 13;11(2). Epub 2019 Feb 13.

Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante, Apartado 99, E03080 Alicante, Spain.

A holographic polymer dispersed liquid crystal (HPDLC) is used to record holographic diffraction gratings. Several mixtures of nematic liquid crystals (LC) are used as components of the HPDLC to evaluate their influence in static and dynamic basic properties. The diffraction efficiency obtained in the reconstruction of the holograms is evaluated to compare the influence of the different LC. Read More

Polymers (Basel) 2019 Feb 2;11(2). Epub 2019 Feb 2.

Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante, Apartado 99, 03080 Alicante, Spain.

Tert-Butylthiol (TBT) and tetrahydrothiophene (THT) are odorant substances added to natural gas and liquefied petroleum gas to help their detection by the human smell. In this research, TBT and THT are incorporated into a holographic polymer-dispersed liquid crystal and their influence in the main holographic characteristics of the photopolymer are studied in order to open the way towards the design of a holographic sensor to detect natural gas and liquefied petroleum gas. Read More

Polymers (Basel) 2019 Apr 6;11(4). Epub 2019 Apr 6.

Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante, Apartado de correos 99, Alicante E-03080, Spain.

The storage of volume holographic reflection gratings in low-toxicity photopolymers represents a challenge at present since they can be used in many important applications such as biosensors and holographic optical elements. In this context, an acrylate-based photopolymer developed in our research group was employed to study the recording of unslanted holographic reflection gratings at high spatial frequencies. The optimal preparation conditions of the photopolymer layers were determinated. Read More

Tumour Biol 2019 Apr;42(4):1010428319835684

1 Unidad de Investigación, Hospital Costa del Sol, REDISSEC, Marbella, España.

We investigate the clinical and pathological features related to variations in colorectal tumour apoptosis, proliferation and angiogenesis and the influence of the latter in short-term mortality (2 years); 551 tumour samples from a prospective cohort of patients with colorectal cancer were examined and tumour biology markers were determined as follows: percentage of apoptotic cells, by the terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling technique; Ki-67 antigen, as a cell proliferation marker and density of microvessels (as a marker of angiogenesis). An increase in the percentage of cellular apoptosis is significantly related to the presence of poorly differentiated tumours, with vascular invasion (p < 0.001). Read More

J Matern Fetal Neonatal Med 2019 Apr 18:1-2. Epub 2019 Apr 18.

c Area of Pathology, Department of Woman, Child Health and Public Health , Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Istituto di Anatomia Patologica, Università Cattolica del Sacro Cuore , Rome , Italy.

eNeuro 2019 Mar-Apr;6(2). Epub 2019 Apr 2.

Departamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid 28029, Spain.

Rodents use rhythmic whisker movements at frequencies between 4 and 12 Hz to sense the environment that will be disturbed when the animal touches an object. The aim of this work is to study the response adaptation to rhythmic whisker stimulation trains at 4 Hz in the barrel cortex and the sensitivity of cortical neurons to changes in the timing of the stimulation pattern. Longitudinal arrays of four iridium oxide electrodes were used to obtain single-unit recordings in supragranular, granular, and infragranular neurons in urethane anesthetized mice. Read More

Vet Microbiol 2019 Apr 20;231:18-23. Epub 2019 Feb 20.

IRTA, Centre de Recerca en Sanitat Animal (CRESA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. Electronic address:

This study aimed to describe Mycoplasma hyopneumoniae (M. hyopneumoniae) genetic variability in vaccinated (V) and non-vaccinated (NV) slaughtered pigs showing cranio-ventral pulmonary consolidation (CVPC). Ten V and 10 NV fattening farms with respiratory problems associated to M. Read More

BMC Cancer 2019 Apr 5;19(1):324. Epub 2019 Apr 5.

Diretor do Departamento de Patologia Clínica e Anatomia Patológica do Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: We are reporting a rare case of MUTYH-associated polyposis, a colorectal cancer hereditary syndrome, diagnosticated after an intussusception. Colorectal cancer is an important cause of cancer related mortality that can be manifested by an intussusception, a rare occurrence in adults and almost always related to tumors. Approximately 5% of colorectal cancers can be attributed to syndromes known to cause hereditary colorectal cancer, such as MUTYH-associated polyposis, autosomal genetic syndrome associated with this disease. Read More

J Gerontol A Biol Sci Med Sci 2019 Apr 6. Epub 2019 Apr 6.

Department of Physiology, Institute of Nutrition and Food Technology "Jose Mataix", Biomedical Research Center, University of Granada, Avda. Conocimiento s/n, Armilla, Granada, Spain.

Extending life by delaying the aging process have proven to be the most effective way to fight multiple chronic diseases in elderly adults. Evidence suggests that longevity is inversely related to unsaturation of membrane phospholipids. The present study investigated how different unsaturated dietary fats affect lifespan and cause death in male Wistar rats fed diets based on virgin olive oil (V), sunflower oil (S) or fish oil (F), which were supplemented or not with Coenzyme Q10 (CoQ10). Read More

Front Genet 2019 20;10:225. Epub 2019 Mar 20.

Departamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Universidade de Santiago de Compostela, Lugo, Spain.

[This corrects the article DOI: 10.3389/fgene.2019. Read More

World J Gastroenterol 2019 Mar;25(12):1465-1477

Istituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, Roma 00168, Italy.

Background: Anti-tumor necrosis factor α (TNFα) represents the best therapeutic option to induce mucosal healing and clinical remission in patients with moderate-severe ulcerative colitis. On the other side gut microbiota plays a crucial role in pathogenesis of ulcerative colitis but few information exists on how microbiota changes following anti-TNFα therapy and on microbiota role in mucosal healing.

Aim: To elucidate whether gut microbiota and immune system changes appear following anti TNFα therapy during dextran sulfate sodium (DSS) colitis. Read More

Nat Commun 2019 04 2;10(1):1498. Epub 2019 Apr 2.

Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, 62500, Czech Republic.

WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) of the developing hindbrain, but not the telencephalon, in both mouse and human. Read More

Mar Drugs 2019 Mar 29;17(4). Epub 2019 Mar 29.

División de Investigación en Salud, Unidad Médica de Alta Especialidad, Hospital de Cardiología No. 34, Instituto Mexicano del Seguro Social (IMSS), Av. Lincoln S/N esquina con Enfermera María de Jesús Candia, Col. Valle Verde 2do. Sector, 64360 Monterrey, Nuevo León, México.

Macroalgae represent an important source of bioactive compounds with a wide range of biotechnological applications. Overall, the discovery of effective cytotoxic compounds with pharmaceutical potential is a significant challenge, mostly because they are scarce in nature or their total synthesis is not efficient, while the bioprospecting models currently used do not predict clinical responses. Given this context, we used three-dimensional (3D) cultures of human breast cancer explants to evaluate the antitumoral effect of laurinterol, the major compound of an ethanolic extract of . Read More

Environ Pollut 2019 Mar 11;249:453-462. Epub 2019 Mar 11.

Ecotoxicology of Aquatic Microorganisms Laboratory, GRIL, TOXEN, Department of Biological Sciences, Université du Québec à Montréal, Montréal Succ. Centre-Ville, H3C 3P8, Montréal, QC, Canada.

The co-occurrence of aquatic contaminants, such as antibiotics and herbicides, has motivated investigations into their interactive effects on aquatic organisms. We examined the combined effects of environmental concentrations of the antibiotic Enrofloxacin (Enro; 0-2.25 μg l) and Roundup Original (Roundup; 0-0. Read More

J Anat 2019 Mar 29. Epub 2019 Mar 29.

Departamento de Morfología y Biología Celular, Grupo SINPOS Universidad de Oviedo, Oviedo, Spain.

Decline of tactile sensation associated with ageing depends on modifications in skin and both central and peripheral nervous systems. At present, age-related changes in the periphery of the somatosensory system, particularly concerning the effects on mechanoreceptors, remain unknown. Here we used immunohistochemistry to analyse the age-dependent changes in Meissner's and Pacinian corpuscles as well as in Merkel cell-neurite complexes. Read More

Arch Pathol Lab Med 2019 Apr;143(4):416-417

1  Department of Diseases of the Thorax (Drs Ravaglia, Tomassetti, and Poletti), G.B. Morgagni - L. Pierantoni Hospital, Forlì, Italy.

Mol Genet Genomic Med 2019 Mar 27:e608. Epub 2019 Mar 27.

Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela, Spain.

Background: Autosomal recessive congenital ichthyoses (ARCI) have been associated with different phenotypes including: harlequin ichthyosis (HI), congenital ichthyosiform erythroderma (CIE), and lamellar ichthyosis (LI). While pathogenic variants in all ARCI genes are associated with LI and CIE phenotypes, the unique gene associated with HI is ABCA12. In HI, the most severe ARCI form, pathogenic variants in both ABCA12 gene alleles usually have a severe impact on protein function. Read More

Breast J 2019 Mar 27. Epub 2019 Mar 27.

Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Anatomia Patologica, Università Cattolica del Sacro Cuore, Rome, Italy.

The characterization of breast cancer according to its proliferative activity and the expression of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor-2 is a laboratory routine that has been adopted worldwide for prognostic and therapeutic purposes. By combining data on the expression of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor-2, it is possible to obtain 8 tumor patterns categorized as triple-negative, nonluminal (i.e. Read More

Arq Bras Oftalmol 2019 Mar 25. Epub 2019 Mar 25.

Servicio de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain.

This report was written to describe a case of unilateral brimonidine-induced conjunctival lichen planus. Because the ophthalmic examination indicated chronic conjunctivitis or drug-induced pseudopemphigoid, the patient underwent thorough ophthalmic and systemic examinations, as well as conjunctival biopsy and direct immunofluorescence studies. A 71-year-old woman with unilateral left eye findings of chronic conjunctivitis was referred to our Ophthalmology Department. Read More

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Departamento de Biorregulação, Laboratório de Estudo da Tireoide, Instituto de Saúde e Ciência, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil.

Objectives: We aimed to investigate the prevalence of the BRAF (V600E) mutation in consecutive cases of papillary thyroid carcinoma (PTC) in patients diagnosed and treated at the Hospital Sao Rafael (Salvador, BA, Brazil) and evaluate its association with clinical and pathological characteristics of PTC.

Subjects And Methods: We retrospectively enrolled in the study a total of 43 consecutive PTC patients who underwent total thyroidectomy. We performed DNA extraction from formalin-fixed paraffin-embedded (FFPE) tumour tissue samples. Read More

Rev Esp Enferm Dig 2019 Mar 26;111. Epub 2019 Mar 26.

Cirugía General y del Aparato Digestivo, Hospital Universitario de Gran Canaria Dr. Negrín.

In relation to the interesting article published recently in your scientific journal titled "Hirschsprung disease with debut in adult age as acute intestinal obstruction: a case report" , we would like to provide an exceptional case where the evolution of Hirschsprung's disease and an infrequent surgical complication developed in the long term are combined. Read More

Int J Hyperthermia 2019 26;36(1):376-382. Epub 2019 Mar 26.

aa Division of Interventional Radiology , IEO, European Institute of Oncology IRCCS , Milan , Italy.

Benign thyroid nodules are a common clinical occurrence and usually do not require treatment unless symptomatic. During the last years, ultrasound-guided minimally invasive treatments (MIT) gained an increasing role in the management of nodules causing local symptoms. In February 2018, the Italian MIT Thyroid Group was founded to create a permanent cooperation between Italian and international physicians dedicated to clinical research and assistance on MIT for thyroid nodules. Read More

J Dairy Res 2019 Feb;86(1):3-12

Departamento de Patoloxía Animal, Facultade de Veterinaria,Universidade de Santiago de Compostela,27002 Lugo,Spain.

Organic farming is believed by many to be an environmentally friendly production system that promotes the use of local forage while strongly limiting the input of chemicals, including allopathic treatments. As organic dairy farming has grown, farmers have realised that many available conventional breeds of cow are not well adapted to the new situations and that more 'robust' cows, able to function well in the constraining organic environment, are needed to yield acceptable longevity and productivity. In this review paper, the current breed diversity in organic dairy farming is analysed with the aim of identifying the types of cow that would best fulfil organic breeding goals. Read More

Radiologia 2019 Mar 21. Epub 2019 Mar 21.

Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Background And Objectives: The standard treatment for endometrial cancer is simple hysterectomy with bilateral salpingo-oophorectomy. Patients with high risk also benefit from lumbo-aortic lymphadenectomy. High risk patients include those with grades and histologic subtypes associated with poor prognosis and depth of myometrial invasion greater than 50% (M2). Read More