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J Med Chem 2021 May 4. Epub 2021 May 4.

Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Puerto Real, 11510 Cádiz, Spain.

A small library of phorbol 12,13-diesters bearing low lipophilicity ester chains was prepared as potential neurogenic agents in the adult brain. They were also used in a targeted UHPLC-HRMS screening of the latex of . Two new 12-deoxy-16-hydroxyphorbol 13,16-diesters were isolated, and their structures were deduced using two-dimensional NMR spectroscopy and NOE experiments. Read More

Ann Med Hist 1927 Jun;9(2):180-182

Omaha, Nebraska.

Anat Rec (Hoboken) 2021 May 4. Epub 2021 May 4.

Departamento de Medicina Legal, Psiquiatría y Anatomía Patológica, Universidad Complutense de Madrid, España.

Arch Esp Urol 2021 May;74(4):419-426

Instituto de Medicina y Biología Experimental de Cuyo (IMBECU). Centro Científico y Tecnológico Mendoza. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Mendoza. Argentina.

Introduction: Prolactin (PRL) binds its receptor (PRLR) and stimulates cell proliferation, differentiation and survival in prostate cancer (PCa) cell lines via STAT5a, MAPK and AKT.

Objective: To evaluate the expression of PRL and PRLR in normal and tumor prostate tissues with different Gleason patterns.

Methods: Samples of normal, benign prostatic hyperplasia and PCa with different Gleason patterns were selected from radical prostatectomy. Read More

Actas Dermosifiliogr 2021 Apr 30. Epub 2021 Apr 30.

Servicio de Dermatología. Hospital General Universitario de Alicante, Alicante, España.

Recent years have seen important advances in our understanding of calciphylaxis, especially regarding newly identified risk factors and histologic findings that may aid diagnosis. This retrospective study of cases of calciphylaxis treated in our hospital in the last 13 years focuses on newly revealed aspects of this disease. We describe 16 patients (62. Read More

Actas Dermosifiliogr 2021 Apr 30. Epub 2021 Apr 30.

Departamento de Anatomía Patológica, Hospital Universitario Son Espases, Palma de Mallorca, España.

Actas Dermosifiliogr 2021 Apr 30. Epub 2021 Apr 30.

Servicio de Dermatología, Complejo Hospitalario de Navarra, Spain.

Dis Colon Rectum 2021 May;64(5):576-582

1 Surgical Anatomy Unit, Department of Human Anatomy and Embryology, Faculty of Medicine and Dentistry. University of Valencia, Spain 2 European Center for Colorectal Surgery, Coloproctology Unit, Vithas Valencia, Valencia, Spain 3 Department of General and Digestive Surgery, Coloproctology Unit, University General Hospital Consortium, Valencia, Spain 4 Department of General and Digestive Surgery, Coloproctology Unit, Son Espases University Hospital, Palma de Mallorca, Spain.

Background: Below the anterior peritoneal reflection, the anterior rectal wall and mesorectum are separated from the posterior vaginal wall by a virtual rectovaginal space. In this space, the description of a specific and independent rectovaginal septum as a female counterpart of Denonvilliers fascia has been the subject of debate over the years.

Objective: The aim of this study is to perform an accurate anatomical study of the rectovaginal area in a cadaveric simulation model of total mesorectal excision to evaluate the possible structures and the dissection planes contained within the rectovaginal space. Read More

Acta Neuropathol 2021 May 2. Epub 2021 May 2.

Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain.

Tauopathies, including Alzheimer's disease (AD) and frontotemporal lobar degeneration with Tau pathology (FTLD-tau), are a group of neurodegenerative disorders characterized by Tau hyperphosphorylation. Post-translational modifications of Tau such as phosphorylation and truncation have been demonstrated to be an essential step in the molecular pathogenesis of these tauopathies. In this work, we demonstrate the existence of a new, human-specific truncated form of Tau generated by intron 12 retention in human neuroblastoma cells and, to a higher extent, in human RNA brain samples, using qPCR and further confirming the results on a larger database of human RNA-seq samples. Read More

BMC Med Educ 2021 May 1;21(1):250. Epub 2021 May 1.

Departamento de Anatomia Humana. Francisco I. Madero and Jose E. Gonzalez sin número, Colonia Mitras Centro Monterrey, Universidad Autónoma de Nuevo León, Facultad de Medicina, 64460, Monterrey, Nuevo León, Mexico.

Background: Acquisition of Basic Surgical Skills (BSS) are essential for medical students. The objective was to determine it's fidelity impact.

Methods: Using four suturing models (SM) (pigskin, sponge, commercial pad, and orange), SM-quality and student-SM interaction were evaluated. Read More

Int J Gynecol Cancer 2021 May;31(5):797-798

Servicio de Anatomía Patológica, Clínica Universidad de Navarra, Madrid, Spain.

Int J Mol Sci 2021 Apr 27;22(9). Epub 2021 Apr 27.

Department of Anatomy, Histology and Neuroscience, Medical School, Autónoma University of Madrid, 28029 Madrid, Spain.

Craniofacial neuropathic pain affects millions of people worldwide and is often difficult to treat. Two key mechanisms underlying this condition are a loss of the negative control exerted by inhibitory interneurons and an early microglial reaction. Basic features of these mechanisms, however, are still poorly understood. Read More

Cancers (Basel) 2021 Apr 27;13(9). Epub 2021 Apr 27.

Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.

Recently, retrospective analysis began to shed light on metastatic colorectal cancers (mCRCs) harboring rare non-V600 mutations, documenting a distinct phenotype and a favorable prognosis. This study aimed to confirm features and prognosis of rare non-V600 mCRCs compared to V600E and wild-type mCRCs treated at two Italian Institutions. Overall, 537 cases were retrospectively evaluated: 221 wild-type, 261 mutated, 46 V600E and 9 non-V600. Read More

Int J Mol Sci 2021 Apr 16;22(8). Epub 2021 Apr 16.

Department of Health Surveillance and Bioethics, Section of Legal Medicine, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Inherited cardiomyopathies are frequent causes of sudden cardiac death (SCD), especially in young patients. Despite at the autopsy they usually have distinctive microscopic and/or macroscopic diagnostic features, their phenotypes may be mild or ambiguous, possibly leading to misdiagnoses or missed diagnoses. In this review, the main differential diagnoses of hypertrophic cardiomyopathy (e. Read More

Diagnostics (Basel) 2021 Apr 16;11(4). Epub 2021 Apr 16.

Unità di Gineco-Patologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.

Background: To date, useful diagnostic applications of p16 IHC have been documented in gynecological pathology both for HPV-related and non-HPV-related lesions. In the present article, we reported our experience with the novel anti-p16 INK4a antibody (clone BC42), whose expression was tested across all different gynecologic neoplasms; we also compared it to the traditional E6H4 clone. Moreover, we discussed and explored all the diagnostic applications of p16 IHC in gynecologic pathology. Read More

Diagnostics (Basel) 2021 Apr 15;11(4). Epub 2021 Apr 15.

Unità di Ginecopatologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Roma, Italy.

Colonization of breast carcinoma by non-neoplastic melanocytes of epidermal origin was first described by Azzopardi and Eusebi in 1977. We herein report two cases on the exceptional clinical and pathological features of this phenomenon in a 66-year-old and a 51-year-old patients. The pathogenesis is not fully understood, but a disrupted basement membrane and the role of tumoral growth factors are considered essential. Read More

Cells 2021 Apr 15;10(4). Epub 2021 Apr 15.

Departamento de Anatomía y Biología Celular, Instituto de Investigación Sanitaria Marqués de Valdecilla (IDIVAL), Universidad de Cantabria, 39011 Santander, Spain.

During limb formation in vertebrates with free digits, the interdigital mesoderm is eliminated by a massive degeneration process that involves apoptosis and cell senescence. The degradation process is preceded by intense DNA damage in zones located close to methylated DNA, accompanied by the activation of the DNA repair response. In this study, we show that trimethylated histone 3 (H3K4me3, H3K9me3, and H3K27me3) overlaps with zones positive for 5mC in the nuclei of interdigital cells. Read More

Int J Mol Sci 2021 Apr 14;22(8). Epub 2021 Apr 14.

Departamento de Anatomía Humana, Medicina Legal e Historia de la Ciencia, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, 29071 Málaga, Spain.

Deficiency of pregnancy-associated plasma protein-A2 (PAPP-A2), an IGF-1 availability regulator, causes postnatal growth failure and dysregulation of bone size and density. The present study aimed to determine the effects of recombinant murine IGF-1 (rmIGF-1) on bone composition and remodeling in constitutive knock-out (ko/ko) mice. To address this challenge, X-ray diffraction (XRD), attenuated total reflection-fourier transform infra-red (ATR-FTIR) spectroscopy and gene expression analysis of members of the IGF-1 system and bone resorption/formation were performed. Read More

Int J Environ Res Public Health 2021 Apr 9;18(8). Epub 2021 Apr 9.

Departamento de Bioquímica, Biología Molecular y Fisiología, Facultad de Ciencias de la Salud, GIR de Ejercicio Físico y Envejecimiento, Campus Universitario "Los Pajaritos", Universidad de Valladolid, 42004 Soria, Spain.

Objective: The work of health professionals in hospital emergency rooms is highly demanding due to the decisions they must take. In the present study, we consider assessing stress response in emergency health workers, measuring related biomarkers such as cortisol, dehydroepiandrosterone (DHEA) and salivary α-amylase during the whole working day.

Method: An analytical, descriptive and cross-sectional study was carried out. Read More

Int J Mol Sci 2021 Apr 6;22(7). Epub 2021 Apr 6.

UOC Radiodiagnostica e Neuroradiologia, Istituto di Radiologia, Fondazione Policlinico Universitario "A.Gemelli" IRCCS, Università Cattolica S.Cuore, 00168 Roma, Italy.

Magnetic resonance imaging (MRI) is the gold standard for glioblastoma (GBM) patient evaluation. Additional non-invasive diagnostic modalities are needed. GBM is heavily infiltrated with tumor-associated macrophages (TAMs) that can be found in peripheral blood. Read More

Animals (Basel) 2021 Apr 3;11(4). Epub 2021 Apr 3.

Dipartimento di Medicina Veterinaria, Sez, Patologia Aviare, Università Degli Studi di Bari, Strada Provinciale Per Casamassima Km.3, 70010 Valenzano, Italy.

Large numbers of wild animals are injured every year in road traffic accidents. Scant data are available for rescued wild carnivores, in particular for red foxes. Cases of foxes with head trauma were retrospectively considered for inclusion in this study. Read More

Biomedicines 2021 Apr 4;9(4). Epub 2021 Apr 4.

Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, Spain.

Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or 15 months after diagnosis is low. It is therefore necessary to identify new therapeutic targets to fight GBM progression and recurrence. Read More

J Eur Acad Dermatol Venereol 2021 Apr 29. Epub 2021 Apr 29.

Servicio de Dermatología. Hospital do Meixoeiro. EOXI. Vigo.

A caliber persistent artery (CPA) is a vascular anomaly where an arterial branch reaches the epithelial or mucosa surface, without branching or reducing its diameter. Pulsatile beat can erode these surfaces causing bleeding . We present a case of CPA in a unique location, the nape. Read More

Front Oncol 2021 12;11:663489. Epub 2021 Apr 12.

Unit of Medical Oncology and Biomolecular Therapy, Polilinico Riuniti, Foggia, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Malignant Brenner Tumor (mBT) is extremely rare. Although BT are almost exclusive ovarian neoplasms, they may constitute a highly unusual tumor of the testis; in fact, only seven fully documented cases have been reported to date. Because of their rarity, the pathogenesis of these tumors has not been clarified and there is no standard therapeutic approach. Read More

Front Oncol 2021 12;11:628027. Epub 2021 Apr 12.

Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, México.

Breast cancer (BRCA) is a serious public health problem, as it is the most frequent malignant tumor in women worldwide. BRCA is a molecularly heterogeneous disease, particularly at gene expression (mRNAs) level. Recent evidence shows that coding RNAs represent only 34% of the total transcriptome in a human cell. Read More

Indian J Dermatol 2021 Jan-Feb;66(1):93-95

Servicio de Dermatología, Hospital Universitario de Cabueñes, Gijón. E-mail:

J Neurosci 2021 Apr 19. Epub 2021 Apr 19.

Departamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, 28029, Spain

Insulin-like growth factor-I (IGF-I) signalling plays a key role in learning and memory processes. While the effects of IGF-I on neurons have been studied extensively, the involvement of astrocytes in IGF-I signalling and the consequences on synaptic plasticity and animal behavior remain unknown. We have found that IGF-I induces long-term potentiation (LTP, here called LTP) of the postsynaptic potentials that is caused by a long-term depression (LTD) of inhibitory synaptic transmission in mice. Read More

PLoS One 2021 28;16(4):e0249935. Epub 2021 Apr 28.

R&D Department, APC EUROPE, S.L.U., Granollers, Barcelona, Spain.

Spray-dried animal plasma (SDAP) is widely used in diets of domestic animals to improve health status and increase growth and feed efficiency. Individual steps in the SDAP manufacturing process, including spray-drying, have been validated to inactivate potential pathogens. Manufacturing standards have established a minimum exit temperature of 80°C and a minimum post-drying storage period of 14 days at 20°C for production of SDAP. Read More

Arch Endocrinol Metab 2021 Apr 27. Epub 2021 Apr 27.

Departamento de Ciencias Básicas, Universidad Católica de la Santísima Concepción, Concepción, Chile,

Objective: To study the association of gene variants with obesity and metabolic markers in nondiabetic Chilean adults.

Methods: This cross-sectional study included 263 non-diabetic adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by real-time PCR. Read More

Protoplasma 2021 Apr 28. Epub 2021 Apr 28.

Instituto de Ciências Biológicas, Laboratório de Anatomia Vegetal, Departamento de Botânica, Universidade Federal de Minas Gerais, Caixa postal 486, Belo Horizonte, Minas Gerais, CEP: 31270-901, Brazil.

Gall cytological, metabolic, and structural traits are established due to the feeding habits of the associated galling herbivores, and sometimes are influenced by other organisms involved in the interaction. We tested this assumption on three gall morphotypes, the globoid, the lenticular, and the fusiform, induced by Cecidomyiidae on leaflets of Inga ingoides (Rich.) Willd. Read More