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J Pathol 2020 Jun 3. Epub 2020 Jun 3.

CITAB, Universidade de Trás-os-Montes e Alto Douro, UTAD, Vila Real, Portugal.

Penile cancer is an under-studied disease that occurs more commonly in developing countries and 30-50% of cases show high-risk human papillomavirus (HPV) infection. Therapeutic advances are slow, largely due to the absence of animal models for translational research. Here, we report the first mouse model for HPV-related penile cancer. Read More

Surg Radiol Anat 2020 Jun 1. Epub 2020 Jun 1.

Departamento de Anatomía Humana, Facultad de Medicina, Universidad Autónoma de Nuevo León, Francisco I. Madero and Aguirre Pequeño Sin Numero, Colonia Mitras Centro Monterrey, 64460, Nuevo León, Mexico.

Purpose: To determine the anatomical variations and morphology of the external carotid artery (ECA) and its anterior branches.

Methods: Using computed tomography angiography (CTA), the origin, internal diameter, and surface laterality emergence of the superior thyroid (STA), lingual (LA), and facial (FA) arteries were evaluated retrospectively evaluated and classified. The bifurcation level of the common carotid artery (CCA) in relation to the cervical vertebrae and disc was also determined. Read More

Acta Otorrinolaringol Esp 2020 May 30. Epub 2020 May 30.

Servicio de Otorrinolaringología, Hospital Universitario Virgen de la Victoria, Málaga, España.

Pathogens 2020 May 31;9(6). Epub 2020 May 31.

OIE Collaborating Centre for the Research and Control of Emerging and Re-Emerging Swine Diseases in Europe (IRTA-CReSA), 08193 Bellaterra, Spain.

The genus includes several species and mostly causes asymptomatic infections. (PCV-2) and, with increasing evidence, (PCV-3), have been associated with different clinical conditions all over the world. In 2019, a new porcine circovirus (PCV-4) was identified from diseased animals in China. Read More

Funct Plant Biol 2016 Oct;43(10):973-985

Cátedra de Fisiología Vegetal, Facultad de Ciencias Naturales e IML, Miguel Lillo 205, CP 4000, Tucumán, Argentina.

The effect of cadmium on roots of four citrus rootstocks was studied to assess the relationships between oxidative stress, carbohydrates, phenolics and antioxidant responses. Swingle citrumelo (SC), Rangpur lime (RL), Troyer citrange (TC) and Volkamer lemon (VL) genotypes were exposed to 0, 5 and 10µM Cd over 7 days, after which Cd accumulation was markedly higher in roots compared with stems and leaves. Malondialdehyde (MDA) and lipoxygenase (LOX) activity increased in Cd-treated SC and RL roots, suggesting that a lipid peroxidation is the main driver of plasma membrane damage. Read More

Biochim Biophys Acta Mol Cell Res 2020 May 30:118761. Epub 2020 May 30.

Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Hemato-Oncologia Molecular, Instituto Nacional de Câncer (INCA), Praça da Cruz Vermelha, 23, 6° andar, Centro, 20 230 130 Rio de Janeiro, RJ, Brazil. Electronic address:

Evasion from apoptosis is one of the hallmarks of cancer. X-linked inhibitor of apoptosis protein (XIAP) is known to modulate apoptosis by inhibiting caspases and ubiquitinating target proteins. XIAP is mainly found at the cytoplasm, but recent data link nuclear XIAP to poor prognosis in breast cancer. Read More

Rep Pract Oncol Radiother 2020 Jul-Aug;25(4):527-532. Epub 2020 May 22.

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Roma, Italy.

Aim: This manuscript focuses on the first experience in literature of a patient with a complicated Adult Onset Still's Disease-related heart failure who thereafter underwent adjuvant radiotherapy for left breast cancer.

Background: AOSD is a rare autoimmune inflammation-related disease, in which life-threatening pulmonary and cardiac complications can occur. In literature, AOSD is often associated with cancer, as paraneoplastic syndrome, but there are few data about primary AOSD and management of oncological therapies. Read More

Reumatol Clin 2020 May 28. Epub 2020 May 28.

Servicio Medicina Interna. Hospital Universitario Puerta de Hierro Majadahonda, Madrid, España.

Introduction: Temporal arteritis is an uncommon disorder in young people. A 39-year-old woman with juvenile temporal arteritis is described and we performed a literature review of all cases of juvenile temporal arteritis described to date.

Case Presentation: A 39-year-old woman presented with a subcutaneous temporal nodule in the right temple with no other associated symptoms or background and unremarkable physical examination. Read More

Clin Rheumatol 2020 May 29. Epub 2020 May 29.

Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHULN, Centro Académico de Medicina de Lisboa, Lisbon, Portugal.

Giant cell arteritis (GCA) is a granulomatous vasculitis involving large- and middle-sized arteries, with a predilection for cranial arteries. In this paper, we aim to describe a case of a biopsy- and ultrasound-proven GCA, presenting with anterior ischemic optic neuropathy (AION) and normal CRP and ESR at diagnosis and during follow-up, and to review the literature on GCA cases with low inflammatory markers, with a particular focus on the presence of eye involvement. Both CRP and ESR are important in the diagnosis of GCA; occurrence of this disease with normal acute phase reactants is unusual but does not rule out the diagnosis. Read More

Actas Dermosifiliogr 2020 May 26. Epub 2020 May 26.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España; Escuela de Medicina, Universidad Católica de Valencia San Vicente Mártir, Valencia, España. Electronic address:

Redox Biol 2020 May 16;34:101575. Epub 2020 May 16.

Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain. Electronic address:

AMP-activated protein kinase (AMPK) is a cellular energy sensor activated during energy stress to stimulate ATP production pathways and restore homeostasis. AMPK is widely expressed in the kidney and involved in mitochondrial protection and biogenesis upon acute renal ischemia, AMPK activity being blunted in metabolic disease-associated kidney disease. Since little is known about AMPK in the regulation of renal blood flow, the present study aimed to assess the role of AMPK in renal vascular function. Read More

PLoS One 2020 29;15(5):e0233468. Epub 2020 May 29.

Oryzon Genomics, S.A., Cornellà de Llobregat, Spain.

Transcription disequilibria are characteristic of many neurodegenerative diseases. The activity-evoked transcription of immediate early genes (IEGs), important for neuronal plasticity, memory and behavior, is altered in CNS diseases and governed by epigenetic modulation. KDM1A, a histone 3 lysine 4 demethylase that forms part of transcription regulation complexes, has been implicated in the control of IEG transcription. Read More

Naturwissenschaften 2020 May 28;107(3):24. Epub 2020 May 28.

Laboratorio de Anatomía Comparada y Evolución de los Vertebrados, Museo Argentino de Ciencias Naturales "Bernardino Rivadavia", Av. Ángel Gallardo 470, C1405DJR, Buenos Aires, Argentina.

The fossil record of basal paravians in Gondwana is still poorly known, being limited to the Cretaceous unenlagiids from South America and the problematic Rahonavis from Madagascar. Here we report on a new paravian from the Cenomanian-Turonian (Late Cretaceous) of Río Negro province, NW Patagonia, Argentina. The new taxon exhibits a derived bird-like morphology of the forelimbs (e. Read More

Acta Otorrinolaringol Esp 2020 May 11. Epub 2020 May 11.

Servicio de Medicina Laboral, Hospital del Mar, Parc de Salut Mar, Barcelona, España.

There is debate as to whether olfactory dysfunction should be considered a symptom of COVID-19 infection. We undertook a systematic literature review of the articles indexed in PubMed on olfactory disorders in viral respiratory tract conditions, with special emphasis on COVID-19. The main objective was to find evidence of clinical interest to support the relationship between anosmia and COVID-19. Read More

Med Clin (Barc) 2020 May 24. Epub 2020 May 24.

Servicio de Anatomía Patológica, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, España.

Parasitology 2020 May 28:1-34. Epub 2020 May 28.

Grupo Integrado de Pesquisas em Biomarcadores, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), 30190-002, Belo Horizonte, MG, Brazil.

Plast Reconstr Surg 2020 Jun;145(6):1037e-1049e

Rio de Janeiro, Brazil; and Verona, Italy From the Programa de Pós-Graduação em Ciências Cirúrgicas and the Instituto de Biofísica Carlos Chagas Filho, Laboratório de Imunopatologia, Universidade Federal do Rio de Janeiro; the Dipartamento di Scienze Neurologiche e del Movimento, Sezione di Anatomia e Istologia della Universitá degli Studi di Verona; the Unità di Chirurgia Rigenerativa dela Clinica San Francesco; and the Centro de Medicina Regenerativa, Faculdade de Medicina de Petrópolis.

Background: The major intrinsic cause of facial skin degeneration is age, associated with extrinsic factors such as exposure to sun. Its major pathologic causes are degeneration of the elastin matrix, with loss of oxytalan and elaunin fibers in the subepidermal region, and actinic degeneration of elastin fibers that lose their functional properties in the deep dermis. Therapy using autologous adipose mesenchymal stem cells for regeneration of extracellular matrix in patients with solar elastosis was addressed in qualitative and quantitative analyses of the dermal elastic fiber system and the associated cells. Read More

Arch Pathol Lab Med 2020 Jun;144(6):671

Imagepat Anatomia Patologica, Salvador, Bahia, Brazil.

Parasitol Res 2020 May 26. Epub 2020 May 26.

IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Catalonia, Spain.

Bulls chronically affected by bovine besnoitiosis can suffer from sterility. There is limited information about the distribution of Besnoitia cysts and their associated lesions within the male genital organs. This work describes the gross and histological abnormalities in the genital organs of 6 bulls chronically infected with Besnoitia besnoiti, including both clinically (n = 4) and subclinically (n = 2) affected cases. Read More

Acta Cytol 2020 May 26:1-17. Epub 2020 May 26.

Department of Medicine and Surgery, Università degli Studi di Salerno, Fisciano, Salerno, Italy,

Background: The evaluation of lymph nodes (LN) by fine-needle aspiration cytology (FNAC) is routinely used in many institutions but it is not uniformly accepted mainly because of the lack of guidelines and a cytopathological diagnostic classification. A committee of cytopathologists has developed a system of performance, classification, and reporting for LN-FNAC.

Methods: The committee members prepared a document that has circulated among them five times; the final text has been approved by all the participants. Read More

Am J Gastroenterol 2020 May 25. Epub 2020 May 25.

Department of Medical Sciences, Division of Gastroenterology and Hepatology, A.O. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.

Introduction: We investigated the longitudinal impact of antinuclear antibody (ANA) on clinical outcomes and survival in nonalcoholic fatty liver disease (NAFLD).

Methods: ANA were found in 16.9% of 923 biopsy-proven NAFLD patients, but none of them had histologic autoimmune hepatitis (AIH) or developed AIH after a mean follow-up of 106±50 months. Read More

Actas Dermosifiliogr 2020 May 22. Epub 2020 May 22.

Servicio de Anatomía Patológica, Hospital Universitario Infanta Sofía, Spain.

BMJ Open 2020 May 24;10(5):e035796. Epub 2020 May 24.

Prevention and Implementation Group, International Agency for Research on Cancer, Lyon, Rhône-Alpes, France.

Introduction: Human papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV testing sensitivity, particularly in low-income and middle-income countries (LMICs), where cytology performance has been suboptimal. Read More

Arch Bronconeumol 2020 May 20. Epub 2020 May 20.

Servicio de Anatomía Patológica, Hospital Clínico Universitario Valladolid, Valladolid, España.

Med Intensiva 2020 May 20. Epub 2020 May 20.

Servicio de Anatomía Patológica, Hospital Universitario de Burgos, Burgos, España.

Microsc Res Tech 2020 May 23. Epub 2020 May 23.

Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

This study represents the first morphological description of the lymphatic drainage of the ciliary body in vivo by comparative hyperspectral fluorescence imaging techniques of Quantum Qdot655 (QD) nanoparticles and indocyanine green (ICG). A volume of 1.25 μl of QD was injected into the left anterior camera of all rats. Read More

Endocrinol Diabetes Nutr 2020 May 19. Epub 2020 May 19.

Departamento de Endocrinología y Nutrición, Hospital del Mar, Barcelona, España.

Int J Mol Sci 2020 May 20;21(10). Epub 2020 May 20.

Instituto de Biomarcadores de Patologias Moleculares, Universidad de Extremadura, 06006 Badajoz, Spain.

3-Nitropropionic acid (NPA) administration to rodents produces degeneration of the striatum, accompanied by neurological disturbances that mimic Huntington's disease (HD) motor neurological dysfunctions. It has been shown that inflammation mediates NPA-induced brain degeneration, and activated microglia secreting cytokines interleukin-1α (IL-1α) and tumor necrosis factor α (TNFα) can induce a specific type of reactive neurotoxic astrocytes, named A1, which have been detected in post-mortem brain samples of Huntington's, Alzheimer's, and Parkinson's diseases. In this work we used an experimental model based on the intraperitoneal (i. Read More

Medicina (B Aires) 2020 ;80(3):280-284

Servicio de Anatomía Patológica, Hospital Británico de Buenos Aires, Argentina.

Desmoplastic melanoma is a rare presentation of melanoma with a different clinical behavior compared to other histological variants. Its diagnosis in early stages is a challenge due to its variable clinical presentation, with a predominant dermal component and the frequent absence of pigment. Its histology is divided into pure and mixed type, and this classification has important prognostic implications. Read More

Rheumatology (Oxford) 2020 May 23. Epub 2020 May 23.

Dipartimento di Scienze Cliniche e Molecolari, Clinica Medica, Università Politecnica delle Marche, Ancona, Italy.

Objectives: Gut microbiota has been widely reported to be involved in systemic inflammation through microbial translocation and T cell activation in several diseases. In this work we aimed to investigate bacterial infiltration and epithelial impairment in the gut of patients with IBD-associated SpA (SpA-IBD), as well as the relationship of microbial translocation with immune system activation and their putative role in the pathogenesis of joint inflammation in IBD patients.

Methods: Tight-junction proteins (TJPs) occludin and claudin-1/-4 and bacteria were assessed by real-time PCR analysis and immunohistochemical staining of the ileum. Read More

Clin Chem Lab Med 2020 May 22. Epub 2020 May 22.

Dipartimento di Medicina di Laboratorio, Azienda Ospedaliera Universitaria di Padova, and Dipartimento di Medicina - Università di Padova, Padova, Italy.

Important advances achieved in pharmacological cancer treatment have led progressively to a reduction in mortality from many forms of cancer, and increasing numbers of previously incurable patients can now hope to become cancer-free. Yet, to achieve these improved outcomes a high price has been paid in terms of untoward side effects associated with treatment, cardio-toxicity in particular. Several recent studies have reported that cardiac troponin assay using high-sensitivity methods (hs-cTn) can enable the early detection of myocardial injury related to chemotherapy or abuse of drugs that are potentially cardiotoxic. Read More

J Chemother 2020 May 22:1-13. Epub 2020 May 22.

Clinical Pharmacology Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

We studied the predictive value for response and toxicity of functional polymorphisms in genes involved in the oxaliplatin/fluorouracil pathway in colorectal cancer patients. One hundred and twenty-seven (127) patients were treated with curative intended surgery followed by adjuvant chemotherapy with FOLFOX (fluorouracil, leucovorin and oxaliplatin) regimen. The median age was 65. Read More

Med Clin (Barc) 2020 May 18. Epub 2020 May 18.

Servicio de Anatomía Patológica, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España.

Cir Esp 2020 May 18. Epub 2020 May 18.

Unidad de Cirugía Hepato-Bilio-Pancreática y Trasplante de Órganos Abdominales, Servicio de Cirugía General, Hospital Universitario 12 de Octubre, Madrid, España; Departamento de Cirugía, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, España.

Introduction: The hepatic cystic tumour is a very rare neoplasm, representing about 5% of all cystic liver neoplasms. The preoperative diagnosis is difficult and can lead to confusion. The aim of this study is to analyze a number of cases operated at our centre with an histologic diagnosis of liver cystic neoplasms and also to describe the sintomathology, diagnosis and management as per the recent classification. Read More

Semin Musculoskelet Radiol 2020 Apr 21;24(2):113-124. Epub 2020 May 21.

Department of Health Sciences (DISSAL), Università di Genova, Genova, Italy.

Ligament injuries around the subtalar, talocalcaneonavicular, and calcaneocuboid joints are often underestimated on clinical and imaging findings during investigation of patients with ankle and foot injuries. Because a delayed diagnosis of midtarsal ligament tears may lead to chronic pain and functional disability, an in-depth knowledge of the complex regional anatomy and of the appropriate ultrasound scanning technique is a prerequisite for evaluating these structures and avoiding misdiagnoses. The objective of this article is twofold: to describe the relevant anatomy and biomechanics related to the ligaments that stabilize the subtalar, talocalcaneonavicular, and calcaneocuboid joints, and to illustrate reasoned landmark-based scanning techniques to provide a systematic examination of these ligaments and thus make ultrasound an effective tool for assessment of patients with suspected subtalar or midtarsal sprain. Read More

Semin Musculoskelet Radiol 2020 Apr 21;24(2):101-112. Epub 2020 May 21.

Department of Health Sciences (DISSAL), Università di Genova, Genova, Italy.

With the advent of high-frequency ultrasound (US) transducers, new perspectives have been opened in evaluating millimetric and submillimetric nerves that, despite their dimensions, can be considered relevant in clinical practice. In the posterior triangle of the neck, the suprascapular, long thoracic, phrenic, supraclavicular, great auricular, lesser occipital, and transverse cervical nerves are amenable to US examination and the object of special interest because they may be involved in many pathologic processes or have a value as targets of advanced therapeutic procedures. The correct identification of these nerves requires a deep knowledge of local neck anatomy and the use of a complex landmarks-based approach with US. Read More

Actas Dermosifiliogr 2020 May 16. Epub 2020 May 16.

Servicio de Dermatología, Clínica Dermatológica Internacional, Madrid, España.

F1000Res 2020 27;9:52. Epub 2020 Jan 27.

Department of Pathology, Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, 77555, USA.

A novel coronavirus recently identified in Wuhan, China (SARS-CoV-2) has expanded the number of highly pathogenic coronaviruses affecting humans. The SARS-CoV-2 represents a potential epidemic or pandemic threat, which requires a quick response for preparedness against this infection. The present report uses the informational spectrum methodology to identify the possible origin and natural host of the new virus, as well as putative therapeutic and vaccine targets. Read More

Kidney Int Rep 2020 May 17. Epub 2020 May 17.

U.O. Nefrologia, Azienda Ospedaliero-Universitaria di Parma.

J Orthop 2020 Nov-Dec;22:203-206. Epub 2020 Mar 26.

Red Clínica Universidad de Chile, 7910000, Chile.

Objective: Our purpose was to evaluate the validity and reliability of the laxity with the GNRB arthrometer in subjects with anterior cruciate ligament injury.

Material And Method: A diagnostic study was performed by three operators using the Genourob arthrometer, measuring the displacement of the anterior cruciate ligament. The concordance was assessed by the intraclass correlation coefficient mixed effects model, Lin correlation coefficient and graphic method from Bland-Altman. Read More

Indian J Hematol Blood Transfus 2020 Apr 28;36(2):442-443. Epub 2019 Oct 28.

2Dipartimento di Scienze Mediche e Sanità Pubblica, SC Ematologia e CTMO, Ospedale Businco, P.O. Businco, Università di Cagliari, Azienda Ospedaliera Brotzu, Via Jenner, sn, 09124 Cagliari, Italy.

G Ital Cardiol (Rome) 2020 Jun;21(6):457-468

Dipartimento CardioToracoVascolare "De Gasperis", ASST Grande Ospedale Metropolitano Niguarda, Milano.

"Athlete's heart" represents a series of mechanisms through which cardiac chambers can adapt to physical activity. Echocardiography has a major role in sports cardiology and it can help physicians to investigate the so-called "grey zones", defined as diagnostic overlaps between athlete's heart and several cardiac diseases: wall thickness and left ventricular size in hypertrophic and dilated cardiomyopathy, ventricular trabeculations in left ventricular non-compaction cardiomyopathy, left atrial size and atrial fibrillation, right ventricular systolic dysfunction in arrhythmogenic right ventricular cardiomyopathy. The use of advanced ultrasound methods such as tissue Doppler and two-dimensional strain can be added to the classic echocardiographic assessment to complete a multi-parametric evaluation, guiding the sports physician and cardiologist in the correct framing of these patients. Read More

J Assist Reprod Genet 2020 May 19. Epub 2020 May 19.

Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo -CEBBAD, Universidad Maimónides, C1405BCK, Buenos Aires, Argentina.

Purpose: The objective of this study was to analyse the expression and cellular localization of FOXO3, pFOXO3 and PTEN throughout human ovary development both before and after birth.

Methods: Foetal, pubertal and adult paraffin-embedded ovarian samples were analysed by immunohistochemistry for cellular localization of FOXO3, pFOXO3 and PTEN proteins. Protein and mRNA expression were analysed by western blot and real time PCR, respectively, from fresh biopsies. Read More

Sci Rep 2020 May 18;10(1):8173. Epub 2020 May 18.

Laboratorio de Óptica, Instituto Universitario de Investigación en Óptica y Nanofísica, Universidad de Murcia, Campus de Espinardo (Ed. 34), 30100, Murcia, Spain.

Over the last decades, the prevalence of myopia has suddenly increased, and at this rate, half of the world's population will be myopic by the year 2050. Contemporary behavioural and lifestyle circumstances, along with emergent technology, are thought to be responsible for this increase. Twin studies mostly reported a high heritability of refractive error across ethnicities. Read More

Actas Dermosifiliogr 2020 May 15. Epub 2020 May 15.

Departamento de Dermatología, Hospital Universitari Son Espases, Palma de Mallorca, Islas Baleares, España.

Nutrients 2020 May 14;12(5). Epub 2020 May 14.

Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, Biomedical Research Center, University of Granada, Avda del Conocimiento sn, Armilla, 18016 Granada, Spain.

Increasing evidence connects periodontitis with a variety of systemic diseases, including metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD progression to non-alcoholic steatohepatitis. Male rabbits were maintained on a commercial standard diet or a diet rich in saturated fat (3% lard /) and cholesterol (1. Read More

Clin Transl Oncol 2020 May 16. Epub 2020 May 16.

Department of Pathology, University of Valencia, Hospital Clínico Universitario de Valencia, CIBERONC, Valencia, Spain.

In this update of the consensus of the Spanish Society of Medical Oncology (Sociedad Española de Oncología Médica-SEOM) and the Spanish Society of Pathology (Sociedad Española de Anatomía Patológica-SEAP), advances in the analysis of biomarkers in advanced colorectal cancer (CRC) as well as susceptibility markers of hereditary CRC and molecular biomarkers of localized CRC are reviewed. Recently published information on the essential determination of KRAS, NRAS and BRAF mutations and the convenience of determining the amplification of human epidermal growth factor receptor 2 (HER2), the expression of proteins in the DNA repair pathway and the study of NTRK fusions are also evaluated. From the pathological point of view, the importance of analysing the tumour budding and poorly differentiated clusters, and its prognostic value in CRC is reviewed, as well as the impact of molecular lymph node analysis on lymph node staging in CRC. Read More

J Neuropathol Exp Neurol 2020 Jun;79(6):626-640

Instituto de Anatomía, Histología y Patología.

Choroid plexus (CP) may aid brain development and repair by secreting growth factors and neurotrophins for CSF streaming to ventricular and subventricular zones. Disrupted ventricular/subventricular zone progenitors and stem cells lead to CNS maldevelopment. Exploring models, we organ cultured the CP and transplanted fresh CP into a lateral ventricle of postnatal hydrocephalic (hyHTx) and nonhydrocephalic (nHTx) rats. Read More

Actas Dermosifiliogr 2020 May 14. Epub 2020 May 14.

Servicio de Dermatología, Hospital Universitario Infanta Sofía, Madrid, Spain.

Background And Objective: Frontal fibrosing alopecia is an increasingly common form of scarring alopecia. The aim of this study was to describe the demographic and clinical characteristics of patients with FFA seen at the trichology unit of a medium-sized regional hospital and to report on treatments used.

Material And Methods: We reviewed the medical records of all patients with FFA seen at the trichology unit of Hospital Universitario Infanta Sofía in Madrid, Spain between May 2016 and May 2018. Read More

Actas Dermosifiliogr 2020 May 13. Epub 2020 May 13.

Servicio de Dermatología, Hospital do Meixoeiro, EOXI Vigo, Vigo, España.