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    1 OF 545

    A case of a 7-year-old girl with late-onset anaphylaxis to fermented soybeans.
    Pediatr Allergy Immunol 2017 May 22. Epub 2017 May 22.
    Department of Allergy, Kanagawa Children's Medical Center, Yokohama, Japan.
    Fermented soybean (natto) is a traditional food in Japan. Because natto is rich in vitamin K2, it affects both thrombolysis and bone metabolism and has been widely marketed throughout the world as a health food. Most people with a soybean allergy can safely consume fermented soybean products such as miso (soybean paste), soy sauce, and natto because the fermentation process weakens the immunoreactivity of the soybean protein. Read More

    Patterns of anaphylaxis after diagnostic work-up: a follow-up study of 226 patients with suspected anaphylaxis.
    Allergy 2017 May 19. Epub 2017 May 19.
    Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark.
    Background: Most published studies on anaphylaxis are retrospective or register based. Data on subsequent diagnostic work-up are sparse. We aimed to characterize patients seen with suspected anaphylaxis at the emergency care setting (ECS), after subsequent diagnostic work-up at our Allergy Center (AC). Read More

    [Dengue with unusual clinical features in an infant: Case report].
    Rev Chil Pediatr 2017 Apr;88(2):275-279
    Hospital General Dr. Agustín O’Horán, Mérida, Yucatán, México.
    The state of Yucatan, in Mexico, is an endemic area for dengue. During 2015, there was an unpredicted increase in the number of expected cases of dengue fever.

    Objective: To describe and analyse the clinical presentation, progress, and management of a case of dengue infection with non-specific clinical manifestations in an infant which resulted in a dengue shock syndrome. Read More

    Fast Real-Time PCR for the Detection of Crustacean Allergens in Foods.
    Methods Mol Biol 2017 ;1620:163-171
    ANFACO-CECOPESCA, Carretera Colegio Universitario, Nº 16, 36310, Vigo, Spain.
    Crustaceans are one of the most common allergens causing severe food reaction. Hypersensitivity reactions associated with seafood intake are one of the most common food allergies in adults. Crustaceans including shrimps, prawns, crabs, lobster, and crayfish are a common cause of anaphylaxis or hypersensitivity, with shrimps and crabs being the most common causes of allergy. Read More

    [Anaphylactic reactions to vaccines : Chicken egg allergy and the influenza H1N1 vaccination].
    HNO 2017 May 24. Epub 2017 May 24.
    HNO-Universitätsklinik Mannheim, Mannheim, Deutschland.
    Background: Allergic reactions to influenza vaccinations are a well-known phenomenon; however, only a few published statistics give information on the risks. Patients with a chicken egg allergy must be particularly carefully handled during an influenza epidemic where vaccines produced using embryonated chicken eggs are primarily employed.

    Methods: A selective literature review and analysis of the problem of allergic reactions to vaccinations was performed. Read More

    Hypersensitivity reactions to gadolinium-based contrast agents.
    Curr Opin Allergy Clin Immunol 2017 May 22. Epub 2017 May 22.
    aDepartment of General Medicine bDepartment of Clinical Immunology and Allergy, Flinders Medical Centre, Bedford Park cDepartment of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
    Purpose Of Review: Gadolinium-based contrast agents (GBCAs) have been utilized since the late 1980s to enhance the diagnostic value of MRI studies. They are known to have excellent safety profile and serious adverse reactions are uncommon despite widespread global use. However, immediate hypersensitivity reactions are well described in the literature, with urticaria the most common manifestation. Read More

    Asthma, Food Allergy, and How They Relate to Each Other.
    Front Pediatr 2017 9;5:89. Epub 2017 May 9.
    Division of Asthma, Allergy and Lung Biology, Department of Paediatric Allergy, King's College London, Guy's and St. Thomas' Hospitals NHS Foundation Trust, London, UK.
    The association between atopic diseases is well known, and previous research has shown that having one atopic disease can predispose to having another. The link between asthma and food allergy has been well researched, but the exact relationship between the two atopic conditions is not fully understood. Food allergic infants are at increased risk for the development of asthma and are at risk of food-induced asthmatic episodes and also anaphylaxis. Read More

    Alternative Anaphylactic Routes: The Potential Role of Macrophages.
    Front Immunol 2017 8;8:515. Epub 2017 May 8.
    Faculty of Medicine, IMMA Applied Molecular Medicine Institute, CEU San Pablo University, Madrid, Spain.
    Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators from effector cells. There are two potential pathways for anaphylaxis. The first one, IgE-dependent anaphylaxis, is induced by antigen (Ag) cross-linking of Ag-specific IgE bound to the high-affinity IgE receptor (FcεRI) on mast cells and basophils. Read More

    Management of Kounis syndrome: two case reports.
    J Med Case Rep 2017 May 23;11(1):145. Epub 2017 May 23.
    Faculty of Medicine Ibn El Jazzar of Sousse, Sousse, Tunisia.
    Background: Kounis syndrome corresponds to the occurrence of myocardial injury following an allergic insult. This syndrome is infrequent, and is not well known. In consequence, it is usually misdiagnosed leading to inappropriate treatment. Read More

    An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin.
    Nat Commun 2017 May 19;8:15242. Epub 2017 May 19.
    Laboratory of Functional Chemo-Systems (UMR 7199), Labex Medalis, University of Strasbourg, 74 Route du Rhin, 67401 Illkirch-Graffenstaden, France.
    Drugs, usually long acting and metabolically stable molecules, might be the source of adverse effects triggered by complex drug interactions, anaphylaxis and drug-induced coagulopathy. To circumvent this growing drug safety issue, we herein investigate the opportunity offered by bio-orthogonal chemistry for in vivo drug neutralization. We design a small-molecule anticoagulant drug (Warfarin) containing an azide group that acts as a safety pin. Read More

    Patient-Centered Outcomes in Food Allergy.
    Curr Allergy Asthma Rep 2017 Jun;17(6):39
    Stanford University, Palo Alto, California, USA.
    Purpose Of Review: Food allergy prevalence is increasing very rapidly, causing a significant disease burden. The threat of severe allergic reactions occurring unexpectedly and in settings that are not equipped to recognize and treat anaphylaxis is a constant source of worry for individuals and families with food allergies. Inadequate knowledge and understanding in the community significantly impairs the overall quality of life of these individuals and families. Read More

    An update on the impact of food allergy on anxiety and quality of life.
    Curr Opin Pediatr 2017 May 13. Epub 2017 May 13.
    aChildren's Hospital at Dartmouth, Lebanon bThe Geisel School of Medicine, Hanover, New Hampshire cWhite River Junction VA Medical Center, White River Junction, Vermont dSeton Hill University, Greensburg Pennsylvania, USA.
    Purpose Of Review: Food allergies have become more common, and management involves dietary avoidance that can impair quality of life. Patients and families must manage the daily risk of anaphylaxis at each meal. The purpose of this review is to describe the impact of food allergies on quality of life and to provide an update on new developments in food allergy management, particularly peanut allergy. Read More

    Use of Epinephrine in Patients with Drug-Induced Anaphylaxis: An Analysis of the Beijing Pharmacovigilance Database.
    Int Arch Allergy Immunol 2017 May 16;173(1):51-60. Epub 2017 May 16.
    Department of Pharmacy, Peking University Third Hospital, Beijing, China.
    Background: Few studies assessing the use of epinephrine in drug-induced anaphylaxis (DIA) in the hospital setting are available. We utilized the Beijing Pharmacovigilance Database (BPD) to evaluate the appropriateness of epinephrine for DIA management.

    Methods: DIA cases collected in the BPD from January 2004 to December 2014 were adjudicated and analyzed for demographics, causative drugs, clinical signs, outcomes, initial treatment, route, dosing, and cardiovascular adverse events (CAE) of epinephrine. Read More

    Deficiency of Interleukin-1 Receptor Antagonist (DIRA): Report of the First Indian Patient and a Novel Deletion Affecting IL1RN.
    J Clin Immunol 2017 May 15. Epub 2017 May 15.
    Translational Autoinflammatory Diseases Studies, NIAID, NIH, Bethesda, MD, USA.
    Purpose: Deficiency of interleukin-1 receptor antagonist (DIRA) is a rare life-threatening autoinflammatory disease caused by autosomal recessive mutations in IL1RN. DIRA presents clinically with early onset generalized pustulosis, multifocal osteomyelitis, and elevation of acute phase reactants. We evaluated and treated an antibiotic-unresponsive patient with presumed DIRA with recombinant IL-1Ra (anakinra). Read More

    Diagnostics in Hymenoptera venom allergy: current concepts and developments with special focus on molecular allergy diagnostics.
    Allergo J Int 2017 11;26(3):93-105. Epub 2017 Apr 11.
    Department of Dermatology and Venerology, Medical Center - University of Freiburg, Hauptstraße 7, 79104 Freiburg, Germany.
    Background: The high rate of asymptomatic sensitization to Hymenoptera venom, difficulty in correctly identifying Hymenoptera and loss of sensitization over time make an accurate diagnosis of Hymenoptera venom allergy challenging. Although routine diagnostic tests encompassing skin tests and the detection of venom-specific IgE antibodies with whole venom preparations are reliable, they offer insufficient precision in the case of double sensitized patients or in those with a history of sting anaphylaxis, in whom sensitization cannot be proven or only to the presumably wrong venom.

    Methods: Systematic literature research and review of current concepts of diagnostic testing in Hymenoptera venom allergy. Read More

    Component Resolved Diagnosis in Hymenoptera Anaphylaxis.
    Curr Allergy Asthma Rep 2017 Jun;17(6):38
    Department of Dermatology and Allergy Biederstein, Technische Universität München, Biedersteiner Straße 29, 80802, Munich, Germany.
    Purpose Of Review: Hymenoptera anaphylaxis is one of the leading causes of severe allergic reactions and can be fatal. Venom-specific immunotherapy (VIT) can prevent a life-threatening reaction; however, confirmation of an allergy to a Hymenoptera venom is a prerequisite before starting such a treatment. Component resolved diagnostics (CRD) have helped to better identify the responsible allergen. Read More

    A confirmed case of sugammadex-induced anaphylaxis in a UK hospital.
    BMJ Case Rep 2017 May 13;2017. Epub 2017 May 13.
    Department of Anaesthetics, Ashford and St. Peter's Hospitals NHS Trust, Chertsey, UK.
    We report the first published case of confirmed anaphylaxis to sugammadex in a UK hospital. The patient was given a bolus of sugammadex at the end of surgery. Four minutes later, he developed hypotension and a widespread erythematous rash. Read More

    Fatal Anaphylaxis to Yellow Jacket Stings in Mastocytosis: Options for Identification and Treatment of At-Risk Patients.
    J Allergy Clin Immunol Pract 2017 May 10. Epub 2017 May 10.
    Department of Allergology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
    Background: Patients with indolent systemic mastocytosis (ISM) are at risk for severe anaphylactic reactions to yellow jacket (YJ) stings while demonstration of sensitization can be challenging because specific IgE (sIgE) levels are regularly below 0.35 kUA/L. The implication of missing YJ allergy is illustrated by a case of fatal anaphylaxis. Read More

    A case report of anaphylaxis to Typhoid Vaccine Live Oral Ty21a (Vivotif).
    J Travel Med 2017 Sep;24(5)
    Emergency Physicians Med Group, 2000 Green Rd, Suite 300, Ann Arbor, MI 48105, USA.
    Typhoid Vaccine Live Oral Ty21a (Vivotif) is typically well tolerated, and adverse events are infrequent and mild. To the best of the authors' knowledge, only one prior anaphylactic reaction has previously been reported. We present a case of anaphylaxis related to Vivotif, in which a 66-year-old male with no medical comorbidities developed anaphylaxis following the third of a four-dose course (in the absence of concomitant vaccination administration), which consisted of tongue swelling, difficulty breathing, abdominal discomfort and rash. Read More

    UK anaesthetists' perspectives and experiences of severe perioperative anaphylaxis: NAP6 baseline survey†.
    Br J Anaesth 2017 May 12. Epub 2017 May 12.
    Department of Anaesthesia, Central Manchester University Hospitals Foundation Trust, Manchester M13?9WL, UK.
    Background: There is limited information on UK anaesthetists' perspectives and experiences of perioperative anaphylaxis. This baseline survey of the Sixth National Audit Project (NAP6) aimed to identify relevant departmental preparedness and practices, and individual experiences, perceptions and drug-avoidance patterns.

    Methods: All anaesthetists in 356 UK NHS hospitals were invited to complete an electronic survey. Read More

    In-flight allergic emergencies.
    World Allergy Organ J 2017 4;10(1):15. Epub 2017 May 4.
    Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore.
    Allergic and hypersensitivity reactions such as anaphylaxis and asthma exacerbations may occur during air travel. Although the exact incidence of in-flight asthma and allergic emergencies is not known, we have concerns that this subject has not received the attention it warrants. There is a need to provide passengers at risk and airlines with the necessary measures to prevent and manage these emergencies. Read More

    Dog Footprint in the Heart.
    J Tehran Heart Cent 2016 Oct;11(4):198-202
    Tehran University of Medical Sciences, Tehran, Iran.
    Cardiac manifestations of the hydatid cyst are relatively uncommon. Cardiac involvement may lead to the compression of vital organs, pulmonary hypertension, pericardial effusion, and even anaphylaxis. A 45-year-old woman presented to the Emergency Department of Tehran Heart Center with chest pain. Read More

    Allergen immunotherapy for the treatment of allergic rhinitis and/or asthma: an umbrella review.
    CMAJ Open 2017 May;5(2):E373-E385
    Affiliations: School of Epidemiology, Public Health and Preventive Medicine (Elliott, Kelly, Wells), University of Ottawa; Cardiovascular Research Methods Centre (Elliott, Kelly, Johnston, Wells), University of Ottawa Heart Institute; Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital, Toronto, Ont. Becky Skidmore is an independent contractor in Ottawa, Ont.
    Background: Allergic rhinitis and asthma are important public health concerns, yet there is no consensus about the benefits and harms of allergen-specific immunotherapy to treat these conditions. We performed an umbrella review of systematic reviews summarizing the current evidence for the benefits and harms of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT).

    Methods: We searched MEDLINE, Embase, the Cochrane Library and the grey literature from Jan. Read More

    True and false contraindications to vaccines.
    Allergol Immunopathol (Madr) 2017 May 8. Epub 2017 May 8.
    Department of Clinical and Experimental Medicine, Section of Paediatrics UO Pediatria, University of Pisa, via Roma 67, Pisa, Italy.
    Nowadays, the awareness of risks related to infectious diseases has decreased, whereas THE perception of risks related to vaccination is growing. Therefore, it may be difficult for health care providers to convince people of the importance of vaccination and adherence to the immunisation schedule. Selected situations that might raise uncertainties about vaccine recommendations are discussed in order to help health care providers to identify real and perceived contraindications to vaccines, and cases to be referred to specialised pre-vaccination consultation due to an increased risk of adverse events to vaccines. Read More

    Component-resolved evaluation of the content of major allergens in therapeutic extracts for specific immunotherapy of honeybee venom allergy.
    Hum Vaccin Immunother 2017 May 11. Epub 2017 May 11.
    a Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Member of the German Center of Lung Research (DZL) , Ingolstädter Landstraße 1, D-85764 Munich , Germany .
    Allergen-specific immunotherapy is the only curative treatment for honeybee venom (HBV) allergy, which is able to protect against further anaphylactic sting reactions. Recent analyses on a molecular level have demonstrated that HBV represents a complex allergen source that contains more relevant major allergens than formerly anticipated. Moreover, allergic patients show very diverse sensitization profiles with the different allergens. Read More

    Epinephrine Auto-Injector Versus Drawn Up Epinephrine for Anaphylaxis Management: A Scoping Review.
    Pediatr Crit Care Med 2017 May 10. Epub 2017 May 10.
    1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. 2National Institutes of Health of Library, Bethesda, MD. 3Division of Emergency Medicine, Department of Emergency Medicine, Nationwide Children's Hospital, Columbus, OH. 4Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, MD. 5Armstrong Institute for Patient Safety and Quality, Johns Hopkins Medicine, Baltimore, MD. 6Departments of Pediatrics and Health Informatics, Johns Hopkins University School of Medicine, Baltimore, MD.
    Objective: Anaphylaxis is a life-threatening event. Most clinical symptoms of anaphylaxis can be reversed by prompt intramuscular administration of epinephrine using an auto-injector or epinephrine drawn up in a syringe and delays and errors may be fatal. The aim of this scoping review is to identify and compare errors associated with use of epinephrine drawn up in a syringe versus epinephrine auto-injectors in order to assist hospitals as they choose which approach minimizes risk of adverse events for their patients. Read More

    Higher risk of revision for infection using systemic clindamycin prophylaxis than with cloxacillin.
    Acta Orthop 2017 May 11:1-6. Epub 2017 May 11.
    a The Swedish Knee Arthroplasty Register, Lund University , Skåne University Hospital and Department of Clinical Sciences Lund , Orthopedics , Lund , Sweden.
    Background and purpose - Clindamycin has not been compared with other antibiotics for prophylaxis in arthroplasty. Since 2009, the Swedish Knee Arthroplasty Register (SKAR) has been collecting information on the prophylactic antibiotic regime used at every individual operation. In Sweden, when there is allergy to penicillin, clindamycin has been the recommended alternative. Read More

    Sesame allergy: current perspectives.
    J Asthma Allergy 2017 27;10:141-151. Epub 2017 Apr 27.
    Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.
    Sesame is an important global allergen affecting ~0.1% of the North American population. It is a major cause of anaphylaxis in the Middle East and is the third most common food allergen in Israel. Read More

    Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection.
    Asia Pac Allergy 2017 Apr 6;7(2):115-118. Epub 2017 Apr 6.
    Division of Allergy, Immunology and Rheumatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
    Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any reaction for the previous 10 years. Read More

    Medical certification reduces the number of children requiring allergen elimination diets for school lunches.
    Asia Pac Allergy 2017 Apr 26;7(2):92-96. Epub 2017 Apr 26.
    Department of Pediatrics, Oita University Faculty of Medicine, Oita 879-5593, Japan.
    Background: Following the increase in the number of children with food allergies, support systems are now required for school lunches, but a large-scale factual investigation has not been carried out.

    Objective: We evaluated the features of elimination diet due to food allergy and the support system in kindergartens and schools.

    Methods: A prefecture-based questionnaire survey regarding measures for food allergies in school lunches of all kindergartens, public elementary schools, and public junior high schools (631 facilities) was conducted in Oita Prefecture, Japan. Read More

    Primary hydatid cyst of pineal region of brain: A case report from Saudi Arabia.
    Asian J Neurosurg 2017 Apr-Jun;12(2):314-317
    Consultant Pathologist, Saad Specilaist Hospital, Alkhobar, KSA.
    Preoperative diagnosis of cerebral echinococcosis in an unusual location is always difficult. Nonetheless, this possibility should be kept in mind in all cystic lesions of the brain. Although total excision of the cyst without rupture is a time - tested treatment, but in order to prevent recurrence, adjuvant medical treatment should also be started. Read More

    Positive Skin Test or Specific IgE to Penicillin Does Not Reliably Predict Penicillin Allergy.
    J Allergy Clin Immunol Pract 2017 May - Jun;5(3):676-683
    Odense Research Center for Anaphylaxis, Odense, Denmark; Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark.
    Introduction: According to guidelines, patients are diagnosed with penicillin allergy if skin test (ST) result or specific IgE (s-IgE) to penicillin is positive. However, the true sensitivity and specificity of these tests are presently not known.

    Objective: To investigate the clinical relevance of a positive ST result and positive s-IgE and to study the reproducibility of ST and s-IgE. Read More

    Immediate Hypersensitivity Reaction to Chemotherapeutic Agents.
    J Allergy Clin Immunol Pract 2017 May - Jun;5(3):593-599
    Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Mass.
    An increase by 70% in new cases of cancer is expected over the next 2 decades, with more than 8 million people dying each year from the disease, an estimated 13% of all deaths worldwide. Several new chemotherapeutic agents have been rapidly developed and many of them approved through a fast-track process. In parallel, adverse reactions to chemotherapy have increased dramatically worldwide, frequently preventing the use of first-line therapy for cancer and jeopardizing patients' treatment outcomes. Read More

    Current Knowledge and Management of Hypersensitivity to Perioperative Drugs and Radiocontrast Media.
    J Allergy Clin Immunol Pract 2017 May - Jun;5(3):587-592
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
    Perioperative anaphylaxis is an iatrogenic clinical condition, most often after anesthetic induction. Several mechanisms are implicated, including IgE- and non-IgE-mediated mechanisms. Perioperative anaphylaxis tends to be severe and has a higher mortality rate than anaphylaxis in other settings. Read More

    Progestogen Hypersensitivity: Heterogeneous Manifestations with a Common Trigger.
    J Allergy Clin Immunol Pract 2017 May - Jun;5(3):566-574
    Department of Internal Medicine, Division of Immunology/Allergy Section, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:
    Hypersensitivity to progestogen, previously known as autoimmune progesterone dermatitis, is an increasingly recognized clinical entity that presents specific diagnostic and treatment challenges. Clinical presentations are heterogeneous, but can consist of hypersensitivity symptoms associated with the progesterone surge during the luteal phase of the menstrual cycle or after exposure to exogenous progestins. With the increasing use of exogenous progesterone for contraception and fertility, more cases of hypersensitivity to exogenous progestins have been described. Read More

    Inadequacy of current pediatric epinephrine autoinjector needle length for use in infants and toddlers.
    Ann Allergy Asthma Immunol 2017 May 5. Epub 2017 May 5.
    Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Background: Epinephrine injection represents the standard of care for anaphylaxis treatment. It is most effective if delivered intramuscularly, whereas inadvertent intraosseous injection may be harmful. The needle length in current pediatric epinephrine autoinjectors (EAIs) is 12. Read More

    Adrenaline overdose in pediatric anaphylaxis: a case report.
    J Med Case Rep 2017 May 8;11(1):129. Epub 2017 May 8.
    Department of Emergency Medicine, Flinders Medical Centre, Flinders Drive, Bedford Park, 5042, Adelaide, Australia.
    Background: Adrenaline is the standard treatment for anaphylaxis but appropriate administration remains challenging, and iatrogenic overdose is easily overlooked. Despite the established importance of pediatric blood pressure measurement, its use remains inconsistent in clinical practice.

    Case Presentation: We report a case of adrenaline overdose in a 9-year-old white boy with anaphylaxis, where signs of adrenaline overdose were indistinguishable from progressive shock until blood pressure measurement was taken. Read More

    Swiss Dent J 2017 ;127(3):242-243
    Klinik für Chirurgische Intensivmedizin, UniversitätsSpital Zürich, Zürich, Switzerland.
    Anaphylaxis is defined as a serious allergic or hypersensitivity reaction in the most cases as a result of an IgE-mediated allergic reaction that is rapid in onset and may cause death. Common triggers are foods, insect stings, and medications. The medical treatment includes, epinephrine, glucocorticoids, antihistamines and inhaled bronchodilators, with the aim to prevent progression to life-threatening respiratory and/or cardiovascular symptoms. Read More

    Swiss Dent J 2017 ;127(4):324-325
    Clinique de soins intensifs chirurgicaux, Hôpital universitaire de Zurich, Zurich, Switzerland.
    Anaphylaxis is defined as a serious allergic or hypersensitivity reaction in the most cases as a result of an IgE-mediated allergic reaction that is rapid in onset and may cause death. Common triggers are foods, insect stings, and medications. The medical treatment includes, epinephrine, glucocorticoids, antihistamines and inhaled bronchodilators, with the aim to prevent progression to life-threatening respiratory and/or cardiovascular symptoms. Read More

    Food allergy and attitudes to close interpersonal relationships: an exploratory study on attachment.
    Pediatr Allergy Immunol 2017 May 8. Epub 2017 May 8.
    Referral Centre for Food Allergy Diagnosis and Treatment, Veneto Region, Department of Women and Child Health, Padua University Hospital, Padua, Italy.
    Background: Food allergy is a common immunological disease that includes potentially fatal reactions. It impacts considerably on patients' social life including close interpersonal relationships. Attachment theory provides a theoretical framework to evaluate the quality of close interpersonal relationships in chronic disorders. Read More

    Cross-reactivity in Fish Allergy: A Double-Blind Placebo-Controlled Food Challenge Trial.
    J Allergy Clin Immunol 2017 May 4. Epub 2017 May 4.
    Department of Paediatric and Adolescent medicine, University Hospital of North Norway, Tromsø, Norway; Paediatric Research group, Institute of clinical medicine, University of Tromsø, The Arctic University of Norway.
    One third of fish-allergic patients tolerate at least one fish species. Specific IgE testing can identify most patients with fish allergy and reduce the need of oral challenges in the diagnostic work-up. Read More

    Glycans and Glycan-specific IgE in Clinical and Molecular Allergology - Sensitization, Diagnostics and Clinical Symptoms.
    J Allergy Clin Immunol 2017 May 4. Epub 2017 May 4.
    Division of Clinical and Molecular Allergology, Priority Research Area Asthma & Allergy, Airway Research Center North (ARCN), Member of the German Centre for Lung Research (DZL), Research Center Borstel, Borstel, Germany; Interdisciplinary Allergy Outpatient Clinic, University of Lübeck, Lübeck, Germany. Electronic address:
    Glycan-specific IgE antibodies are cross-reacting with highly similar or even identical carbohydrate structures on a variety of different natural allergens, the so-called cross-reactive carbohydrate determinants (CCDs). In clinical practice, CCDs often interfere with the specificity of in vitro allergy diagnostics, thus impairing allergy therapy decisions for individual patients. Strikingly, these IgE antibodies directed against CCD often do not cause clinically relevant allergy symptoms. Read More

    Skin prick test is more useful than specific IgE for diagnosis of buckwheat allergy: A retrospective cross-sectional study.
    Allergol Int 2017 May 4. Epub 2017 May 4.
    Department of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.
    Background: Buckwheat (BW) is a potentially life-threatening allergen. Usefulness of BW-specific immunoglobulin-E (BW-sIgE) level for diagnosis of BW allergy is controversial, while the skin prick test (SPT) is widely used because of its less invasive procedure and immediate results. However, there are no data comparing usefulness of the SPT and BW-sIgE level. Read More

    Physicians' experience and opinion on contraindications to allergen immunotherapy: The CONSIT survey.
    Ann Allergy Asthma Immunol 2017 May;118(5):621-628.e1
    Section of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute and Royal Brompton Hospital NSH, London, United Kingdom.
    Background: Allergen immunotherapy (AIT) is the only disease-modifying treatment in allergy but several contraindications limit its use.

    Objective: To collect the outcome of using AIT in theoretically contraindicated situations in real patients in the Contraindications to Specific ImmunoTherapy (CONSIT) survey.

    Methods: The CONSIT is an electronic European Academy of Allergy and Clinical Immunology survey conducted to gather the safety outcomes of patients undergoing subcutaneous, sublingual, or venom AIT and the opinions of physicians on each of 17 selected conditions: children younger than 5 years; starting AIT during pregnancy; controlled severe asthma; arrhythmias; coronary disease; cancer; autoimmune disease; bone marrow and solid organ transplantation; human immunodeficiency virus and acquired immunodeficiency syndrome; previous anaphylaxis during AIT; use of β-blockers, angiotensin-converting inhibitors, cyclosporine, and methotrexate; and inability to communicate. Read More

    Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Treatment of Acute Urticaria: A Randomized Double-Blind Clinical Trial.
    Ann Emerg Med 2017 May 2. Epub 2017 May 2.
    Pôle de Médecine d'Urgences, Centre Hospitalier Universitaire, Toulouse, France; Université Paul Sabatier Toulouse III, Toulouse, France; INSERM UMR 1027 Equipe 5, Toulouse, France.
    Study Objective: We evaluate the efficacy of a 4-day course of prednisone added to antihistamine for the management of acute urticaria in an emergency department (ED).

    Methods: In this double-blind randomized clinical trial, patients were eligible for inclusion if aged 18 years or older and with acute urticaria of no more than 24 hours' duration. Patients with anaphylaxis or who had received antihistamines or glucocorticoids during the previous 5 days were not included. Read More

    Sensitizing and Eliciting Capacity of Egg White Proteins in BALB/c Mice As Affected by Processing.
    J Agric Food Chem 2017 May 23. Epub 2017 May 23.
    Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM) , Madrid, Spain.
    This study assesses to what extent technological processes that lead to different degrees of denaturation of egg white proteins affect their allergenicity. We focused on heat (80 °C, 10 min) and high-pressure (400 MPa and 37 °C, 10 min) treatments and used a BALB/c mouse model of food allergy. Oral sensitization to egg white using cholera toxin as adjuvant induced the production of IgE and IgG1 isotypes and led to severe clinical signs following challenge with the allergen. Read More

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