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    Japanese guidelines for allergic rhinitis 2017.
    Allergol Int 2017 Feb 14. Epub 2017 Feb 14.
    Department of Otorhinolaryngology, Head & Neck Surgery, University of Yamanashi, Yamanashi, Japan.
    Like asthma and atopic dermatitis, allergic rhinitis is an allergic disease, but of the three, it is the only type I allergic disease. Allergic rhinitis includes pollinosis, which is intractable and reduces quality of life (QOL) when it becomes severe. A guideline is needed to understand allergic rhinitis and to use this knowledge to develop a treatment plan. Read More

    Japanese guidelines for occupational allergic diseases 2017.
    Allergol Int 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, Saiseikai Kawaguchi General Hospital, Saitama, Japan.
    In 2013, a guideline for occupational allergic diseases was published for the first time in Japan. Occupational allergic diseases are likely to worsen or become intractable as a result of continuous exposure to high concentrations of causative antigens, and are socioeconomically important diseases with which the patients might sometimes lose jobs due to work interruptions. Guidelines for occupational allergic diseases have been published in many countries. Read More

    Immediate Reactions to More Than 1 NSAID Must Not Be Considered Cross-Hypersensitivity Unless Tolerance to ASA Is Verified.
    J Investig Allergol Clin Immunol 2017 ;27(1):32-39
    Allergy Service, Infanta Leonor University Hospital, Madrid, Spain.
    Background And Objectives: Individuals who develop drug hypersensitivity reactions (DHRs) to chemically unrelated nonsteroidal anti-inflammatory drugs (NSAIDs) are considered cross-hypersensitive. The hallmark for this classification is that the patient presents a reaction after intake of or challenge with acetylsalicylic acid (ASA). Whether patients react to 2 or more NSAIDs while tolerating ASA remains to be studied (selective reactions, SRs). Read More

    Key Issues in Hymenoptera Venom Allergy: An Update.
    J Investig Allergol Clin Immunol 2017 ;27(1):19-31
    Hospital Universitario Clínico San Carlos, Madrid, Spain.
    In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed. The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described. Read More

    Safety and feasibility of heated egg yolk challenge for children with egg allergies.
    Pediatr Allergy Immunol 2017 Feb 16. Epub 2017 Feb 16.
    Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.
    Background: Hen's egg allergy is a frequent cause of childhood food allergy. Egg yolk is used in various commonly consumed foods; if children with allergy to hen's egg could eat heated egg yolk, their quality of life (QOL) would improve. No reports exist regarding oral food challenges (OFCs) for heated egg yolk. Read More

    Berberine as a chemical and pharmacokinetic marker of the butanol-extracted Food Allergy Herbal Formula-2.
    Int Immunopharmacol 2017 Feb 13;45:120-127. Epub 2017 Feb 13.
    Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address:
    Rationale: Food Allergy Herbal Formula 2 (FAHF-2) provided protection against peanut anaphylaxis in a murine model and induced beneficial immune-modulation in humans. Butanol-refined FAHF-2, B-FAHF-2, retained safety and efficacy in the peanut allergic murine model at only 1/5 of FAHF-2 dosage. One compound, berberine, was isolated and identified in vitro as a bioactive component present in FAHF-2 and B-FAHF-2. Read More

    Chlorhexidine Allergy in 4 Specialist Allergy Centres in the UK, 2009-2013: Clinical Features and Diagnostic Tests.
    Clin Exp Immunol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Immunology, Southampton General Hospital, Southampton, UK.
    We describe an observational survey of diagnostic pathways in 104 patients attending four specialist allergy clinics in the UK following perioperative hypersensitivity reactions to chlorhexidine reactions. The majority were life threatening. Men undergoing urological or cardiothoracic surgery predominated. Read More

    Guidance on Completing a Written Allergy and Anaphylaxis Emergency Plan.
    Pediatrics 2017 Feb 13. Epub 2017 Feb 13.
    Division of Pediatric Allergy and Immunology, and.
    Anaphylaxis is a potentially life-threatening, severe allergic reaction. The immediate assessment of patients having an allergic reaction and prompt administration of epinephrine, if criteria for anaphylaxis are met, promote optimal outcomes. National and international guidelines for the management of anaphylaxis, including those for management of allergic reactions at school, as well as several clinical reports from the American Academy of Pediatrics, recommend the provision of written emergency action plans to those at risk of anaphylaxis, in addition to the prescription of epinephrine autoinjectors. Read More

    Epinephrine for First-aid Management of Anaphylaxis.
    Pediatrics 2017 Feb 13. Epub 2017 Feb 13.
    Department of Pediatrics & Child Health, and Department of Immunology, College of Medicine, Faculty of Health Sciences, The University of Manitoba, Winnipeg, Canada.
    Anaphylaxis is a severe, generalized allergic or hypersensitivity reaction that is rapid in onset and may cause death. Epinephrine (adrenaline) can be life-saving when administered as rapidly as possible once anaphylaxis is recognized. This clinical report from the American Academy of Pediatrics is an update of the 2007 clinical report on this topic. Read More

    Mast cell secretome: Soluble and vesicular components.
    Semin Cell Dev Biol 2017 Feb 9. Epub 2017 Feb 9.
    Semmelweis University Department of Genetics, Cell- and Immunobiology, H-1089 Budapest, Hungary. Electronic address:
    Mast cells are multifunctional master cells implicated in both innate and adaptive immune responses. Their role has been best characterized in allergy and anaphylaxis; however, emerging evidences support their contribution to a wide variety of human diseases. Mast cells, being capable of both degranulation and subsequent recovery, have recently attracted substantial attention as also being rich sources of secreted extracellular vesicles (including exosomes and microvesicles). Read More

    Characterization of Vancomycin Reactions and Linezolid Utilization in the Pediatric Population.
    J Allergy Clin Immunol Pract 2017 Feb 8. Epub 2017 Feb 8.
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Penn State Hershey Medical Center, Hershey, Pa. Electronic address:
    Background: Red man syndrome (RMS) occurs because of non-IgE-mediated histamine release. Unlike vancomycin allergy, which necessitates the use of an alternative drug (often linezolid), RMS does not typically preclude further vancomycin use. Care should be taken to differentiate these reaction types from one another to prevent unnecessary vancomycin avoidance. Read More

    Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis.
    J Allergy Clin Immunol 2017 Feb 8. Epub 2017 Feb 8.
    Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark; Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark. Electronic address:

    [Systemic reaction after performing a food prick-to-prick test. A case report].
    Rev Alerg Mex 2017 Jan-Mar;64(1):126-129
    Universidad de Antioquia, IPS Universitaria, Servicio de Alergología Clínica, Medellín, Colombia.
    Background: Skin prick test is the most widely used test for the diagnosis of IgE-mediated conditions. Commercial extracts are used for its performance, but in the case of fruits and vegetables it is preferable using fresh food. Although both tests possess a good safety profile, hypersensitivity reactions have been recorded. Read More

    Kounis Syndrome During Anesthesia: Presentation of Indolent Systemic Mastocytosis: A Case Report.
    A A Case Rep 2017 Feb 8. Epub 2017 Feb 8.
    From the Departments of *Anesthesiology, †Allergy, and §Cardiology, Hospital Universitario de Guadalajara, Castilla-La Mancha, Spain; ‡Department of Surgery, Hospital Universitario Quirónsalud Madrid, Madrid, Spain.
    Mastocytosis comprises a heterogeneous group of disorders characterized by mast cell accumulation and proliferation in distinct organs. Kounis syndrome is defined as the concurrence of acute coronary syndromes with mast cell activation in a setting of allergic or hypersensitivity reactions. This is the first reported case of an intraoperative Kounis syndrome as the onset of an indolent systemic mastocytosis probably triggered by succinylated gelatin infusion during general anesthesia. Read More

    The gaps in anaphylaxis diagnosis and management by French physicians.
    Pediatr Allergy Immunol 2017 Feb 8. Epub 2017 Feb 8.
    Pediatric Pulmonology and Allergy Department, Pôle enfant, Hôpital Jeanne de Flandre, CHRU de Lille and Université Nord de France, 59037, Lille, France.
    Several studies have assessed the knowledge of health professionals in recognition and treatment of anaphylaxis using case-based surveys with conflicting results [1-3]. The proportion of responders able to recognize anaphylaxis and treat with appropriate adrenaline ranged from 56% to 95% [1, 3]. The causes for this under optimal management are not clearly understood. Read More

    Screening for hereditary angioedema (HAE) at 13 emergency centers in Osaka, Japan: A prospective observational study.
    Medicine (Baltimore) 2017 Feb;96(6):e6109
    aDepartment of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine bEmergency and Critical Care Medical Center, Osaka Police Hospital cSenri Critical Care Medical Center, Osaka Saiseikai Senri Hospital dEmergency and Critical Care Medicine, Kishiwada Tokushukai Hospital eSenshu Trauma and Critical Care Center, Rinku General Medical Center fEmergency Division, Osaka Red Cross Hospital gDepartment of Emergency Medicine, Osaka General Medical Center hOsaka Prefectural Nakakawachi Medical Center of Acute Medicine iTraumatology and Critical Care Medical Center, National Hospital Organization Osaka National Hospital jEmergency and Critical Care Medical Center, Osaka City General Hospital kOsaka Mishima Emergency Critical Care Center lDepartment of Critical Care Medical Center, Kinki University School of Medicine mDepartment of Trauma and Critical Care Medicine, Osaka City University Graduate School of Medicine, Osaka nDepartment of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan.
    Hereditary angioedema (HAE) with deficiency of C1 inhibitor (C1-INH) is an autosomal-dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The objective is to study the incidence of HAE among patients who visit the emergency department.This was a 3-year prospective observational screening study involving 13 urban tertiary emergency centers in Osaka prefecture, Japan. Read More

    Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms.
    Clin Mol Allergy 2017 3;15. Epub 2017 Feb 3.
    0000 0001 2151 3065grid.5606.5Allergy and Respiratory Diseases, IRCCS San Martino-IST-University of Genoa, Genoa, Italy.
    Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is partly due to the growing emphasis on a more accurate and careful diagnosis of the molecular mechanisms that do not allow to ignore the real pathogenesis of many symptoms until now unknown, and partly to the fact that the allergic people from 20 years ago represent the elderly population now. Read More

    Safety of Second-Dose Single-Antigen Varicella Vaccine.
    Pediatrics 2017 Feb 7. Epub 2017 Feb 7.
    Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases.
    Background And Objective: In 2006, routine 2-dose varicella vaccination for children was recommended to improve control of varicella. We assessed the safety of second-dose varicella vaccination.

    Methods: We identified second-dose single-antigen varicella vaccine reports in the Vaccine Adverse Event Reporting System during 2006 to 2014 among children aged 4 to 18 years. Read More

    Postmortem Serum Tryptase Levels with Special Regard to Acute Cardiac Deaths.
    J Forensic Sci 2017 Feb 7. Epub 2017 Feb 7.
    Department of Forensic Medicine, Southern Medical University, 1838# Guangzhou Avenue North, Guangzhou, China, 510000.
    An elevated serum tryptase concentration is considered a specific marker for systemic mast cell activation, a central feature of anaphylaxis. However, in some cases of acute cardiovascular death, high concentrations of serum tryptase are also observed. We compared the postmortem serum tryptase concentrations in 74 cases assigned to the following four groups: anaphylactic deaths (Group A, n = 20), acute cardiac deaths (Group ACD, n = 30), acute dissecting aneurysm ruptures (Group ADA, n = 10), and controls (Group C, n = 14). Read More

    Anti-allergic activity of 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) via attenuation of IgE-mediated mast cell activation and inhibition of passive systemic anaphylaxis.
    Toxicol Appl Pharmacol 2017 Feb 4;319:47-58. Epub 2017 Feb 4.
    Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia. Electronic address:
    tHGA, a geranyl acetophenone compound originally isolated from a local shrub called Melicope ptelefolia, has been previously reported to prevent ovalbumin-induced allergic airway inflammation in a murine model of allergic asthma by targeting cysteinyl leukotriene synthesis. Mast cells are immune effector cells involved in the pathogenesis of allergic diseases including asthma by releasing cysteinyl leukotrienes. The anti-asthmatic properties of tHGA could be attributed to its inhibitory effect on mast cell degranulation. Read More

    Modulating immunogenicity of Factor IX by fusion to an immunoglobulin Fc domain: a study using hemophilia B mouse model.
    J Thromb Haemost 2017 Feb 6. Epub 2017 Feb 6.
    Plasma Derivatives Branch, Division of Plasma Protein Therapeutics, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
    Background: Fc-fusion is a platform technology used to increase the circulating half-life of protein and peptide therapeutics. However, there are potential immunological consequences with this approach, such as changes in the molecule's immunogenicity as well as possible interactions with a repertoire of Fc-receptors (FcR) which can modulate immune responses.

    Objectives/methods: Using a mouse hemophilia B (HB) model, we compared the immune responses to infusions of recombinant human Factor IX (hFIX) and hFIX fused to mouse IgG2a-Fc (hFIX-mFc). Read More

    Anaphylaxis during general anaesthesia: experience from a drug allergy centre in the UK.
    Acta Anaesthesiol Scand 2017 Mar;61(3):281-289
    Department of Specialist Allergy and Clinical Immunology, Royal National Throat Nose Ear Hospital, University College London Hospital, London, UK.
    Background: Anaphylaxis during general anaesthesia is rare but often severe. Identification of the cause of anaphylaxis and recommendation of a range of drugs or agents likely to be safer for future surgery is a collaborative venture between the allergists and the anaesthesiologists, but it often poses a significant challenge.

    Methods: A total of 31 patients who attended the Drug Allergy Unit at University College London Hospital with suspected perioperative anaphylaxis between March 2013 and January 2016 were reviewed retrospectively. Read More

    A randomized study of autologous bone marrow-derived stem cells in pediatric cardiomyopathy.
    J Heart Lung Transplant 2017 Jan 5. Epub 2017 Jan 5.
    Department of Cardiology, Great Ormond Street Hospital, London, United Kingdom. Electronic address:
    Background: Bone marrow mononuclear cell fraction has been used as therapy for dilated cardiomyopathy in adults. Although case series are reported, there are no randomized controlled studies in children.

    Methods: We designed a randomized, crossover, controlled pilot study to determine safety and feasibility of intracoronary stem cell therapy in children. Read More

    Conjunctival provocation test in diagnosis of peanut allergy in children.
    Clin Exp Allergy 2017 Feb 4. Epub 2017 Feb 4.
    Department of Paediatrics, Oslo University hospital, PO Box 4956, Nydalen, NO-0424, Oslo, Norway.
    Background: Peanut allergy frequently cause severe allergic reactions. Diagnosis include detection of IgE to peanuts in serum or by skin prick tests. While children may have allergic sensitisation without having clinical peanut allergy, oral peanut challenge is often required for accurate diagnosis. Read More

    Validation of the Prognostic Utility of the Electrocardiogram for Acute Drug Overdose.
    J Am Heart Assoc 2017 Feb 3;6(2). Epub 2017 Feb 3.
    Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU School of Medicine, New York, NY.
    Background: While it is certain that some emergency department patients with acute drug overdose suffer adverse cardiovascular events (ACVE), predicting ACVE is difficult. The prognostic utility of the ECG for heterogeneous drug overdose patients remains to be proven. This study was undertaken to validate previously derived features of the initial ECG associated with ACVE in this population. Read More

    A field trial of recombinant Schistosoma japonicum paramyosin as a potential vaccine in naturally-infected water buffaloes
    Ann Parasitol 2016 ;62(4):295-299
    The overall aims of this project are to assess the safety and immunogenicity of the Schistosoma japonicum vaccine paramyosin among water buffaloes residing in endemic areas. The study was conducted in four villages in Leyte, the Philippines, an area highly endemic for schistosomiasis japonica. One hundred and fifteen (N=115) animals provided baseline stool samples for coprologic examination, with preliminary results using FLOTAC showing a 10% prevalence of schistosomiasis. Read More

    Anaphylaxis caused by honey: a case report.
    Asia Pac Allergy 2017 Jan 26;7(1):48-50. Epub 2017 Jan 26.
    Department Immunoallergology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, E.P.E, 1649-035 Lisbon, Portugal.
    Honey allergy is a very rare, but serious health condition. In this study, we presented 1 patient who had anaphylaxis after the honey allergological investigation with skin prick-prick test with honey. Honey as a food has been associated to allergic reactions and as the increased consumption of honey in health food may increase the incidence of honey-related allergic reactions. Read More

    Administration of the adrenaline auto-injector at the nursery/kindergarten/school in Western Japan.
    Asia Pac Allergy 2017 Jan 26;7(1):37-41. Epub 2017 Jan 26.
    West Japan Research Society Pediatric Clinical Allergy, Fukuoka 811-1394, Japan.
    Background: In view of the increasing prevalence of food allergies, there has been an associated increase in frequency of situations requiring an emergency response for anaphylaxis at the home, childcare facilities and educational institutions.

    Objective: To clarify the situation of adrenaline auto-injector administration in nursery/kindergarten/school, we carried out a questionnaire survey on pediatric physicians in Western Japan.

    Methods: In 2015, self-reported questionnaires were mailed to 421 physicians who are members of the West Japan Research Society Pediatric Clinical Allergy and Shikoku Research Society Pediatric Clinical Allergy. Read More

    Feasibility, Benefits, and Limitations of a Penicillin Allergy Skin Testing Service.
    Ann Pharmacother 2017 Feb 1:1060028017690854. Epub 2017 Feb 1.
    2 University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA.
    Objective: To critically examine the feasibility, benefits, and limitations of an inpatient penicillin skin testing service and how pharmacists can be utilized.

    Data Sources: A PubMed search was performed from July 2016 through September 2016 using the following search terms: penicillin skin testing, penicillin allergy, β-lactam allergy. Additional references were identified from a review of literature citations. Read More

    True rise in anaphylaxis incidence: Epidemiologic study based on a national health insurance database.
    Medicine (Baltimore) 2017 Feb;96(5):e5750
    aDepartment of Internal medicine, SMG-SNU Boramae Medical Center bInstitute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul cDepartment of Internal Medicine, Gyeongsang National University Hospital, Jinju dDepartment of Internal medicine, Seoul National University Bundang Hospital, Seongnam eDepartment of Internal medicine, Seoul National University College of Medicine fDrug Safety Monitoring Center, Seoul National University Hospital, Seoul, Korea.
    The incidence trend of anaphylaxis in Asia is not well investigated. The aim of this study is to estimate the entire population-based incidence of anaphylaxis in Korea using a nationwide administrative database.Data over a 7-year period (2008-2014) was obtained from the Korean National Health Insurance (NHI) claims database which covers 97. Read More

    Early introduction of peanuts.
    JAAPA 2017 Feb 1. Epub 2017 Feb 1.
    Shelley Rickman, Desiree Duby, Michelle Peters, and Carla Freigeh are students in the PA program at High Point (N.C.) University. Mark E. Archambault is director of research and an associate professor at High Point University, and department editor of What's New in. The authors have disclosed no potential conflicts of interest, financial or otherwise.
    Peanut allergy is the most common food allergy and the leading cause of anaphylaxis and death due to food allergy. Despite previous guidelines created by the American Academy of Pediatrics in 2003, peanut allergy has continued to significantly increase over the past decade. Therefore, further research has been done to help clinicians provide more evidence-based recommendations about the timing of introduction of peanuts. Read More

    Gastric vascular and motor responses to anaphylactic hypotension in anesthetized rats, in comparison to those with hemorrhagic or vasodilator-induced hypotension.
    J Physiol Sci 2017 Jan 31. Epub 2017 Jan 31.
    Department of Physiology II, Kanazawa Medical University, Uchinada, Kahoku-gun, Ishikawa, 920-0293, Japan.
    Anaphylactic shock is life-threatening, but pathophysiology of the stomach lesion remains unclear. We determined gastric hemodynamics and gastric functions during anaphylactic hypotension, as compared to hypotension induced by hemorrhage or sodium nitroprusside (SNP) in anesthetized and ovalbumin-sensitized Sprague-Dawley rats. Systemic arterial pressure, portal venous pressure, and gastric arterial blood flow were measured, and gastric vascular resistance (GVR) was determined. Read More

    The Journal of Allergy and Clinical Immunology: In Practice - 2016 Year in Review.
    J Allergy Clin Immunol Pract 2017 Jan 28. Epub 2017 Jan 28.
    Department of Allergy, Kaiser Permanente Southern California, San Diego, Calif.
    As editors, we concluded that it would be helpful to our readers to write a Year in Review article that highlights the Review, Original, and Clinical Communication articles published in 2016 in The Journal of Allergy and Clinical Immunology: In Practice. We summarized articles on the topics of asthma, rhinitis/rhinosinusitis, food allergy, anaphylaxis, drug allergy, urticarial/angioedema, eosinophilic disorders, and immunodeficiency. Within each topic, epidemiologic findings are presented, relevant aspects of prevention are described, and diagnostic and therapeutic advances are enumerated. Read More

    Negative Act d 8 indicates systemic kiwifruit allergy among kiwifruit-sensitized children.
    Pediatr Allergy Immunol 2017 Jan 31. Epub 2017 Jan 31.
    Department of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.
    Kiwifruit allergy appears to be increasing (1). Symptoms of kiwifruit allergy vary from localized oral symptoms to life-threatening anaphylaxis (2, 3). Kiwifruit allergy is generally diagnosed based on medical history, positive specific immunoglobulin E (IgE) to kiwifruit, and oral food challenge (OFC). Read More

    Anaphylaxis in a 4-year-old male caused by contact with grasses: a case report.
    World Allergy Organ J 2017 19;10(1). Epub 2017 Jan 19.
    Universidad de Especialidades Espíritu Santo, School of Medicine, Samborondón, Ecuador ; Respiralab, Respiralab Research Group, Guayaquil, Ecuador.
    Background: Acute urticaria is the presence of urticaria for <6 weeks, and it is the most common type of urticaria in children. Sometimes, it may be associated with anaphylaxis, a life-threatening condition. Urticaria must be differentiated from anaphylaxis because the latter may require emergency treatment. Read More

    Relative Incidence of Acute Adverse Events with Ferumoxytol Compared to Other Intravenous Iron Compounds: A Matched Cohort Study.
    PLoS One 2017 30;12(1):e0171098. Epub 2017 Jan 30.
    Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, Minnesota, United States of America.
    Concerns persist about adverse reactions to intravenous (IV) iron. We aimed to determine the relative safety of ferumoxytol compared to other IV iron compounds. This retrospective cohort study with propensity-score matching for patients and drug doses used the Medicare 20% random sample to identify patients (1) without chronic kidney disease (non-CKD) and (2) with non-dialysis-dependent chronic kidney disease (NDD-CKD) who received a first dose of IV iron in 2010-2012. Read More

    Longitudinal Study of Pediatric Urticaria Pigmentosa.
    Pediatr Dermatol 2017 Jan 30. Epub 2017 Jan 30.
    Department of Dermatology, Mayo Clinic Health System, Eau Claire, Wisconsin.
    Background/objectives: Urticaria pigmentosa (UP) is the most common form of mastocytosis in children and is associated with systemic signs, symptoms, and triggers. To our knowledge, the effect of UP on children's quality of life has not been studied. The objective of the current study was to characterize the natural history, triggers, and complications of pediatric UP, identify prognostic indicators, and determine its effect on quality of life. Read More

    Food Allergy-Related Risk-Taking and Management Behaviors Among Adolescents and Young Adults.
    J Allergy Clin Immunol Pract 2017 Jan 26. Epub 2017 Jan 26.
    Northwestern University Feinberg School of Medicine, Chicago, Ill; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill. Electronic address:
    Background: Food allergy (FA) affects 8% of children and adolescents in the United States. Nearly 40% of those affected have experienced severe reactions. Fatal food-induced anaphylaxis is most common among adolescents and young adults (AYA); however, FA-related risk behaviors persist in this population and factors associated with these behaviors remain unclear. Read More

    A Case of Anaphylaxis to Patent Blue in a Patient with Sentinel Lymph Node Excision.
    Iran J Allergy Asthma Immunol 2016 Dec;15(6):547-550
    Department of Dermatology, Venereology and Allergology, University Hospital, Leipzig, Germany.
    In medicine, patent blue violet (PBV) is utilized for staining lymphatic vessels in sentinel lymph node (SLN) surgery. Moreover, PBV (also called E131 ) is used as food additive. We report on a 51-year-old non-atopic female with early breast cancer, who was scheduled for SLN excision and experienced an intra-operative anaphylactic reaction. Read More

    Inappropriate use of antibiotics in patients undergoing gynecologic surgery.
    Proc (Bayl Univ Med Cent) 2017 Jan;30(1):30-32
    Department of Obstetrics and Gynecology, Scott & White Healthcare, and the Texas A&M School of Medicine and Health Sciences, Temple, Texas.
    We retrospectively examined prophylactic antibiotic use and documentation of wound classification in patients having gynecologic surgery at a tertiary hospital. Of the 326 cases reviewed, 175 (54%) received prophylactic antibiotics when not indicated according to guidelines of the American College of Obstetricians and Gynecologists. Antibiotic administration varied significantly (P < 0. Read More

    The Evidence for and Against Corticosteroid Prophylaxis in At-Risk Patients.
    Radiol Clin North Am 2017 Mar;55(2):413-421
    Department of Radiology, University of Michigan Health System, 1500 East Medical Center Drive, B2-A209P, Ann Arbor, MI 48109, USA.
    Corticosteroid prophylaxis is commonly used for the prevention of allergiclike reactions to iodinated and gadolinium-based contrast material in patients at highest risk of an allergiclike reaction. However, it has only a weak mitigating effect on allergiclike reactions, probably does not affect the severity of subsequent reactions, and does not prevent all reactions. Breakthrough reactions occur, are usually the same severity as the index reaction, and can occasionally be life threatening. Read More

    Precision Medicine in Allergic Disease - Food Allergy, Drug Allergy, and Anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology.
    Allergy 2017 Jan 25. Epub 2017 Jan 25.
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
    This consensus document summarizes the current knowledge on the potential for precision medicine in food allergy, drug allergy and anaphylaxis under the auspices of the PRACTALL collaboration platform. PRACTALL is a joint effort of the European Academy of Allergy and Clinical Immunology (EAACI) and the American Academy of Allergy, Asthma and Immunology (AAAAI), which aims to synchronize the European and American approaches to allergy care. Precision medicine is an emerging approach for disease treatment based on disease endotypes, which are phenotypic subclasses associated with specific mechanisms underlying the disease. Read More

    Anaphylaxis to hidden potato allergens in a peach and egg allergic boy.
    Eur Ann Allergy Clin Immunol 2017 Jan;49(1):45-48
    Allergy Department, Hospital La Paz Instituto de Investigacion (idiPaz), Madrid, Spain.
    More than 170 foods have been identified as being potentially allergenic. However, a minority of these foods cause the majority of reactions. Sweets are frequently implicated in allergic reactions in children with cow's milk, egg, nuts or fruits allergy, and they are the most relevant foods investigated as responsible allergens. Read More

    Hymenoptera Venom Allergy. A closer collaboration is needed between allergists and emergency physicians.
    Eur Ann Allergy Clin Immunol 2017 Jan;49(1):15-17
    Allergy Unit, Loreto Crispi Hospital, ASL Napoli 1 - Centro, Naples, Italy. E-mail:
    Background. Hymenoptera stings are sometimes fatal in venom-allergic patients. Fatalities mostly occur in previously stung subjects, especially those with a history of systemic reactions, and could be avoided if patients were properly informed of the existence of a prevention strategy for insect stings, referred to an allergy follow-up and prescribed auto-injectable epinephrine and/or venom-specific immunotherapy (VIT). Read More

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