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Clin Exp Allergy 2019 Apr 19. Epub 2019 Apr 19.

Department of Allergy and Immunology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Idiopathic anaphylaxis (IA) or spontaneous anaphylaxis is a diagnosis of exclusion when no cause can be identified. The exact incidence and prevalence of IA is not known. The clinical manifestations of IA are similar to other known causes of anaphylaxis. Read More

Front Immunol 2019 3;10:673. Epub 2019 Apr 3.

Department of Allergy and Clinical Immunology, Imperial College, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.

Food anaphylaxis is on the increase, with those who have an allergy to peanuts, tree nuts, milk, and seafood at the highest risk of developing such a reaction. However, the diet in many societies is increasingly varied, much of the food consumed is prepared outside the home, and meals are often composed of many different ingredients. Anaphylaxis may occur to a composite food, and it may be unclear whether the reaction is due to contamination or to a culprit allergen present in an added ingredient. Read More

Int Arch Allergy Immunol 2019 Apr 18:1-8. Epub 2019 Apr 18.

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Background: Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known.

Objective: To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well as drug and healthcare costs.

Methods: Nationwide Allergy Barometer Survey was carried out in the Finnish pharmacies during 1 week in September 2016. Read More

J Transl Int Med 2019 Mar 29;7(1):39-42. Epub 2019 Mar 29.

MIMSR Medical College Latur India, Latur, Maharashtra, India.

A 25-year-old male patient received high-dose intravenous steroids for life-threatening anaphylaxis because of bee sting only for 4 days resulted in reactivation of latent tuberculosis infection (LTBI). Clinical presentation is acute form of progressive pulmonary tuberculosis with pleural efusion that can be misdiagnosed as a community-acquired pneumonia. High index of suspicion with adequate evaluation is must in all cases to have satisfactory treatment outcome. Read More

Z Geburtshilfe Neonatol 2019 Apr 17;223(2):73-84. Epub 2019 Apr 17.

Institut für Rettungs- und Notfallmedizin, Universitätsklinikum Schleswig Holstein.

Maternal emergencies can significantly affect the outcome of pregnancy and childbirth. Since obstetrical emergencies may happen at any time during pregnancy an emergency transport to a hospital nearby may not always be possible. So, obstetrical emergency-management may already become mandatory in a prehospital setting. Read More

Eur J Gastroenterol Hepatol 2019 Apr 15. Epub 2019 Apr 15.

Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

In recent years, the role of atopic dermatitis epidermal skin barrier defects in inducing a transcutaneous allergic sensitization is highly debated, possibly explaining why some children with eczema are sensitized to foods they have never eaten. In our specific situation, the association between coeliac disease and wheat allergy might be particularly harmful owing to unavoidable strict food avoidance. We describe the case of a young boy affected by coeliac disease who, after an occasional unexpected ingestion of gluten, experienced a complete anaphylactic reaction characterized by urticarial, labial angioedema, wheezing, and hypotension. Read More

J Clin Anesth 2019 Apr 13;57:119-120. Epub 2019 Apr 13.

Anesthesiology and Clinical Physiology, Tokyo Medical and Dental University, Japan.

Exp Eye Res 2019 Apr 13. Epub 2019 Apr 13.

Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, D-85764, Neuherberg, Germany. Electronic address:

During an ENU (N-ethyl-N-nitrosourea) mutagenesis screen, we observed a dominant small-eye mutant mouse with viable homozygotes. A corresponding mutant line was established and referred to as Aey69 (abnormality of the eye #69). Comprehensive phenotyping of the homozygous Aey69 mutants in the German Mouse Clinic revealed only a subset of statistically significant alterations between wild types and homozygous mutants. Read More

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e483-e488. Epub 2019 Mar 28.

Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.

Objectives: This study aimed to evaluate the relationship between food allergen sensitisation patterns and allergic manifestations in Omani patients and highlight the importance of specific immunoglobulin E (IgE) testing.

Methods: This retrospective study included all patients referred due to allergic manifestations to the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, from November 2012 to November 2016. Specific IgE blood testing was performed to determine sensitisation to common foods known to cause allergic reactions. Read More

Clin Mol Allergy 2019 4;17. Epub 2019 Apr 4.

1Department of Immunotoxicology, Faculty of Veterinary Medicine, Institute for Risk Assessment Sciences, Utrecht University, Yalelaan 104, 3508 TD Utrecht, The Netherlands.

Background: Improving the safety of subcutaneous immunotherapy (SCIT) for food allergy is necessary to reduce side effects and achieve long-term tolerance. We determined the effect of dietary supplementation with 1% non-digestible short- and long-chain fructo-oligosaccharides (scFOS/lcFOS) on safety and efficacy of SCIT using a peanut allergy mouse model.

Methods: After sensitization, mice received a scFOS/lcFOS or control diet for the rest of the study. Read More

J Immunol 2019 Apr 15. Epub 2019 Apr 15.

Translational Innovation Platform Immunology, EMD Serono Research and Development Institute, Billerica, MA 01821; and

Because of its role in mediating both B cell and Fc receptor signaling, Bruton's tyrosine kinase (BTK) is a promising target for the treatment of autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Evobrutinib is a novel, highly selective, irreversible BTK inhibitor that potently inhibits BCR- and Fc receptormediated signaling and, thus, subsequent activation and function of human B cells and innate immune cells such as monocytes and basophils. We evaluated evobrutinib in preclinical models of RA and SLE and characterized the relationship between BTK occupancy and inhibition of disease activity. Read More

A A Pract 2019 Apr 8. Epub 2019 Apr 8.

From the Department of Anesthesiology, Hamamatsu Rosai Hospital, Japan Organization of Occupational Health and Safety, Hamamatsu, Japan.

In addition to cutaneous, gastrointestinal, hemodynamic, and respiratory symptoms, allergic reactions can induce an acute coronary syndrome in normal or atheromatous coronary arteries and can cause coronary stent thrombosis. Here, we report a case of coronary stent thrombosis due to allergic acute coronary syndrome during anaphylaxis induced by sugammadex in a female patient undergoing general anesthesia. She was emergently treated with percutaneous transluminal coronary balloon angioplasty with catecholamine, vasodilator, and intraaortic balloon support. Read More

Eur Ann Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Postgraduate School of Respiratory Medicine. Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.

Summary: Recent studies have shown the increasing relevance of allergic sensitization to Can f 5, a prostatic kallicrein expressed in the prostate and detectable only in male dogs. The aim of the present study was to establish the frequency, level of sensitization and association with other dog allergens of Can f 5, as assessed by Component Resolved Diagnosis (CRD- ISAC 112, ThermoFisher Scientific, Uppsala, Sweden), in North East Italy. A total of 1403 CRD ISAC 112 were examined retrospectively. Read More

J Allergy Clin Immunol Pract 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology and Allergy, University Hospital Würzburg, Germany.

Background: Hypersensitivity reactions occurring within minutes after intravascular injection of iodinated radiocontrast media (RCM) are common and have been previously considered to be non-allergic. However, in the last decades, evidence is increasing that also genuine RCM allergy may present as either full-blown anaphylaxis or delayed exanthematous skin reaction.

Objectives: We aimed to assess whether allergy diagnostics including skin and provocation testing can differentiate between non-allergic and allergic RCM hypersensitivity by identifying the causative RCM as well as tolerated alternative RCM. Read More

Ann Allergy Asthma Immunol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, Fujita Health University General Allergy Center, Nagoya, Japan.

Allergy Asthma Clin Immunol 2019 29;15:19. Epub 2019 Mar 29.

1Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Natural rubber latex and chlorhexidine have previously been identified as causative substances in perioperative anaphylaxis. A pelvic examinations is generally considered noninvasive, however, this procedure is rarely associated with severe allergic reactions. We reported a rare case of dual latex and chlorhexidine allergies which caused anaphylaxis after pelvic examination in a woman with a history of latex-related fruits allergy. Read More

J Ginseng Res 2019 Apr 1;43(2):282-290. Epub 2018 Mar 1.

Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk, Republic of Korea.

Background: Ginsenoside Rg3 (G-Rg3) is the major bioactive ingredient of and has many pharmacological effects, including antiadipogenic, antiviral, and anticancer effects. However, the effect of G-Rg3 on mast cell-mediated allergic inflammation has not been investigated.

Method: The antiallergic effects of G-Rg3 on allergic inflammation were evaluated using the human and rat mast cell lines HMC-1 and RBL-2H3. Read More

J Allergy Clin Immunol Pract 2019 Apr 8. Epub 2019 Apr 8.

Massachusetts General Hospital, Boston, MA.

Background: Awareness about food allergy and food-induced anaphylaxis (FIA) has increased dramatically over the past decade. It remains unclear, however, whether concordance with guidelines for FIA management has improved over time.

Objective: Our objective was to describe changes in emergency department (ED) concordance with guidelines for FIA management. Read More

J Allergy Clin Immunol Pract 2019 Apr 8. Epub 2019 Apr 8.

Massachusetts General Hospital for Children, Food Allergy Center, Department of Pediatrics, Massachusetts General Hospital, Boston, MA.

Background: While almond-specific IgE-mediated food allergies have traditionally been equated with other tree nut allergies, outcomes of oral food challenges to almond and the utility of clinical testing to predict IgE-mediated almond hypersensitivity is not well known.

Objective: To describe almond oral challenge outcomes and assess the predictive value of clinical testing.

Methods: 603 almond challenges performed for 590 patients, aged 1 to 66 years, were analyzed from Massachusetts General Hospital allergy practices. Read More

J Allergy Clin Immunol Pract 2019 Apr 8. Epub 2019 Apr 8.

Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Hosp Pediatr 2019 Apr 10. Epub 2019 Apr 10.

Departments of Pediatrics and.

Objectives: Intranasal, intramuscular, and intravenous (IV) dexmedetomidine routes have been used successfully for pediatric MRI studies. We designed this retrospective study to determine efficacy and safety of buccal dexmedetomidine for pediatric MRI sedation.

Methods: Medical records were reviewed of outpatient children ages 5 to 18 years who received buccal dexmedetomidine with or without oral midazolam for MRI sedation at a freestanding children's hospital sedation program in 2015 and 2016. Read More

Acta Haematol 2019 Apr 10;142(1):8-12. Epub 2019 Apr 10.

Division of Hematology/Medical Oncology, Department of Pathology and Pediatrics, Oregon Health and Science University, Portland, Oregon, USA,

As the adverse effects of iron deficiency are better recognized, the use of oral and intravenous iron has increased dramatically. Oral iron is often poorly tolerated, with up to 70% or more of patients noting gastrointestinal issues; this may affect adherence to therapy. In addition, many patients will not respond to oral iron due to their underlying illness. Read More

World J Hepatol 2019 Mar;11(3):318-329

Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey.

Background: Most patients with hydatid cysts are asymptomatic, and they are diagnosed incidentally during radiological evaluations performed for other reasons. However, some patients develop symptoms and complications due to cyst size, location, and the relationship between the cyst and adjacent structures. The most serious complications that can occur are rupture of the cysts into the biliary tract, vascular structures, hollow viscus, and peritoneal cavity. Read More

Allergy 2019 Apr 9. Epub 2019 Apr 9.

Allergy Unit, Department of Dermatology, University Hospital, University of Basel, Basel, Switzerland.

Perioperative immediate hypersensitivity reactions are rare. Subsequent allergy investigation is complicated by multiple simultaneous drug exposures, the use of drugs with potent effects and the many differential diagnoses to hypersensitivity in the perioperative setting. The approach to the investigation of these complex reactions is not standardized and it is becoming increasingly apparent that collaboration between experts in the field of allergy/immunology/dermatology and anaesthesiology is needed to provide the best possible care for these patients. Read More

Pediatr Allergy Immunol 2019 Apr 9. Epub 2019 Apr 9.

Section of Immunology, Allergy and Rheumatology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.

Etoposide is a podophyllotoxin used in the treatment of various pediatric neoplasms. Hypersensitivity reactions (HSR) to etoposide have a reported incidence of about 1-3%, with symptoms ranging from mild cutaneous reactions to fatal anaphylaxis. HSR to etoposide are thought to be related to the vehicle used to dissolve etoposide, polysorbate 80, rather than the drug. Read More

Clin Transl Allergy 2019 25;9:19. Epub 2019 Mar 25.

5Department of Dermatology and Allergy Biederstein, Technical University of Munich, Biedersteiner Strasse 29, 80802 Munich, Germany.

Background: In wheat-dependent exercise-induced anaphylaxis (WDEIA), cofactors such as exercise, acetylsalicylic acid (ASA), alcohol or unfavorable climatic conditions are required to elicit a reaction to wheat products. The mechanism of action of these cofactors is unknown, but an increase of gliadin absorption has been speculated. Our objectives were to study gliadin absorption with and without cofactors and to correlate plasma gliadin levels with factors influencing protein absorption in healthy volunteers. Read More

Br J Anaesth 2019 Apr 5. Epub 2019 Apr 5.

Department of Clinical Immunology and Allergy, Australia; Medicine (Immunology & Infectious Diseases), University of Sydney, Sydney, Australia; NSW Health Pathology, Sydney, Australia.

Background: Following diagnosis of neuromuscular blocking agent (NMBA) anaphylaxis, identifying safe alternatives for subsequent anaesthesia is critical. A patient with anaphylaxis to one NMBA can also have an allergic reaction to other NMBAs (cross-reactivity). Whilst drug provocation testing is standard for identifying or excluding allergy, there is significant risk. Read More

J Allergy Clin Immunol Pract 2019 Apr;7(4):1117-1123

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

Insect sting anaphylaxis and mast cell disorders are intertwined in a specific and unusual way. There may be specific subsets of clonal mast cell disorders that are predisposed to sting anaphylaxis. The clinical characteristics of the sting reactions should raise suspicion of underlying mastocytosis (eg, hypotension without hives especially in a male). Read More

J Allergy Clin Immunol Pract 2019 Apr;7(4):1109-1114

Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, Mich.

Mast cell activation syndrome (MCAS) is a rare condition defined by a severe systemic reaction to mast cell (MC)-derived mediators. Most cases present with clinical signs of anaphylaxis, and some have an underlying IgE-dependent allergy. A primary MC disease (mastocytosis) may also be detected. Read More

J Allergy Clin Immunol Pract 2019 Apr;7(4):1097-1106

Mayo Clinic Program for Mast Cell and Eosinophil Disorders, Mayo Clinic, Rochester, Minn.

Patients with clonal mast cell activation syndromes (MCAS) including cutaneous and systemic mastocytosis (SM) may present with symptoms of mast cell activation, but in addition can have organ damage from the local effects of tissue infiltration by clonal mast cells. Patients with nonclonal MCAS may have chronic or episodic mast cell activation symptoms with an increase in serum tryptase and/or urinary metabolites of histamine, prostaglandin D2, and leukotrienes. Symptoms of MCAS and SM can be managed by blockade of mediator receptors (H1 and H2 antihistamines, leukotriene receptor blockade), inhibition of mediator synthesis (aspirin, zileuton), mediator release (sodium cromolyn), anti-IgE therapy, or a combination of these approaches. Read More

J Investig Allergol Clin Immunol 2019 Apr 8. Epub 2019 Apr 8.

Immunoallergy Department, CUF Descobertas Hospital, Lisbon, Portugal.

J Investig Allergol Clin Immunol 2019 Apr 8. Epub 2019 Apr 8.

Allergy Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Br J Anaesth 2019 Apr 4. Epub 2019 Apr 4.

Danish Anaesthesia Allergy Centre, Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital, Gentofte, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Chlorhexidine is an antiseptic with a broad spectrum of activity and a persistent effect on skin. Consequently, it has become an ubiquitous antiseptic in healthcare and the community. As use has become widespread, increasing numbers of cases of allergy have been reported in the literature, including cases of anaphylaxis to chlorhexidine gels used on mucous membranes, chlorhexidine-impregnated devices such as central venous catheters, chlorhexidine preparations used on wounds and broken skin, and cases after dental procedures. Read More

Br J Anaesth 2019 Apr 4. Epub 2019 Apr 4.

Department of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, Australia; Medicine (Immunology & Infectious Diseases), University of Sydney, Sydney, Australia; Medicine (Immunology & Infectious Diseases), NSW Health Pathology, Sydney, Australia.

Background: Neuromuscular blocking agents (NMBAs) remain the leading cause of perioperative anaphylaxis in Australia. Standard evaluation comprises history, skin tests, and in vitro specific immunoglobulin E tests. Drug provocation tests to suspected NMBA culprits are associated with a significant risk. Read More

Ann Allergy Asthma Immunol 2019 Apr;122(4):434

Allergy and Immunology Section, Division of Pulmonary, Allergy and Critical Care Medicine, The Jane and Leonard Korman Respiratory Institute, Sidney Kimmel Medical College at Thomas Jefferson University Jefferson Asthma Allergy & Immunology, Philadelphia, Pennsylvania. Electronic address:

J Allergy Clin Immunol Pract 2019 Apr 2. Epub 2019 Apr 2.

Centre Hospitalier Universitaire de Nancy, Hôpital de Brabois, Service de Dermatologie & Consultation d'Allergo-Anesthésie, Vandœuvre-lès-Nancy, France.

J Allergy Clin Immunol 2019 Apr 2. Epub 2019 Apr 2.

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France; Epidemiology of Allergic and Respiratory Diseases, Department Institute Pierre Louis of Epidemiology and Public Health, INSERM and UPMC Sorbonne Université, Medical School Saint Antoine, Paris, France; INSERM U 1168, VIMA : Ageing and chronic diseases Epidemiological and public health approaches, Villejuif, Université Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny le Bretonneux, France and Euforea, Brussels, Belgium. Electronic address:

Background: Mobile health may be used to generate innovative insights into optimizing treatment to improve allergic rhinitis control.

Objectives: A cross-sectional real world observational study was undertaken in 22 countries to complement a pilot study and bring novel information on medication use, disease control and work productivity in everyday life of patients with allergic rhinitis.

Methods: A mobile phone app (Allergy Diary, freely available Google Play and Apple stores) was used to collect data of daily visual analogue scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular and asthma symptoms, (iii) work, as well as (iv) medication use using a treatment scroll list including all allergy medications (prescribed and over-the-counter (OTC)) customized for 22 countries. Read More

Med Gas Res 2019 Jan-Mar;9(1):54

[This corrects the article DOI: 10.4103/2045-9912.248262]. Read More

J Korean Med Sci 2019 Apr 8;34(13):e109. Epub 2019 Apr 8.

Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.

J Korean Med Sci 2019 Apr 8;34(13):e106. Epub 2019 Apr 8.

Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea.

Background: Anaphylaxis is increasing in young children. The aim of the present study was to analyze the clinical characteristics of anaphylaxis in Korean infants, with a focus on food triggers.

Methods: The study analyzed the medical records of infants aged 0 to 2 years old who had been diagnosed with anaphylaxis in 23 secondary or tertiary hospitals in Korea. Read More

Psychiatr Danub 2019 Mar;31(Suppl 1):60-62

University of Zagreb, School of Medicine, Department of Obstetrics and Gynecology, University Hospital Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia,

Anaphylaxis occuring during pregnancy has a potential to cause devastating damage to the unborn baby and the mother. However, majority of adverse outcomes of anaphylaxis during pregnancy frequently affect the neonates rather than the mothers. The negative neurologic outcomes of the fetus are mostly due to delayed caesarean delivery or inadequate doses of adrenaline during anaphylaxis. Read More

Psychiatr Danub 2019 Mar;31(Suppl 1):50-59

Srebrnjak Children's Hospital, Srebrnjak 100, 10000 Zagreb, Croatia,

Every agent used during the perioperative period may be involved and have the potential to trigger both allergic, IgE and non-IgE reaction as well as non-specific (non-allergic) reactions. In many cases, an allergic mechanism cannot be ruled out and systematic investigations should be tested of all drugs and agents the patient was exposed to prior to the reaction. The complexity of agents used for anaesthesia and surgery present challenges when attempting to identify the culprit drugs and select proper testing to better recognition of trigger. Read More

Parasit Vectors 2019 Apr 3;12(1):154. Epub 2019 Apr 3.

UMR BIPAR, INRA, ANSES, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, Maisons-Alfort, 94700, France.

This primer focuses on a recently diagnosed tick-borne allergic disease known as the alpha-Gal syndrome (AGS). Tick bites induce in humans high levels of IgE antibodies against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) present on tick salivary glycoproteins and tissues of non-catarrhine mammals, leading to the AGS in some individuals. This immune response evolved as a conflict and cooperation between ticks and human hosts including their gut microbiota. Read More

Rev Med Suisse 2019 Apr;15(645):706-709

Service d'immunologie et allergie, Département de médecine, CHUV, 1011 Lausanne.

Allergic reactions to fish are potentially life-threatening. We detail here various reactions to fish, notably anaphylaxis and food protein induced enterocolitis syndrome, as well as confounders such as reactions to the parasite Anisakis and scombroid poisoning. Most IgE-mediated reactions are directed to β-parvalbumin. Read More

Int J Occup Med Environ Health 2019 Apr 2. Epub 2019 Apr 2.

Medical University of Lodz, Łódź, Poland (Department of Oral Surgery).

Objectives: Local anesthetics are some of the most common drugs used in dentistry and about 6 million people daily around the world are subjected to their effect in procedures performed by a similar number of dentists who, in turn, are usually not aware of the fact of being allergic to this group of medications. Assuming that dentists are also patients, and that in their daily practice the contact with the allergen is very frequent, it is essential to assess the incidence of allergy to lidocaine in general dental practitioners.

Material And Methods: The authors evaluated a group of 100 general dental practitioners in whom adverse reactions similar to anaphylaxis occurred after local anesthesia. Read More

J Allergy Clin Immunol Pract 2019 Mar 30. Epub 2019 Mar 30.

Division of Allergy & Clinical Immunology, University of Virginia, Charlottesville, VA. Electronic address:

Background: Red meat allergy has historically been understood as a rare disease of atopic children but the discovery of the 'α-Gal syndrome', which relates to IgE to the oligosaccharide galactose-α-1,3-galactose (α-Gal), has challenged that notion.

Objective: To describe the clinical and immunologic characteristics of a large group of subjects with self-reported allergy to mammalian meat.

Methods: This was an observational study of 261 children and adults (range 5-82 years) who presented for evaluation for allergic reactions to mammalian meat. Read More

Curr Opin Pediatr 2019 Apr 1. Epub 2019 Apr 1.

The Geisel School of Medicine at Dartmouth, Hanover.

Purpose Of Review: To provide an updated framework of management for allergic emergencies.

Recent Findings: The most frequent causes of anaphylaxis include medications, foods, and stinging insects. Early and appropriate administration of epinephrine is critical to managing anaphylaxis. Read More

JAMA 2019 04;321(13):1306-1307

Immunol Med 2018 Jun 30;41(2):85-88. Epub 2018 Jul 30.

a Department of Pediatrics , JCHO Kyoto Kuramaguchi Medical Center , Kyoto , Japan.

We report a case of rocuronium-induced anaphylaxis in a previously healthy 7-year-old boy. The first presenting sign of anaphylaxis was bronchospasm, appearing 11 min after he received intravenous doses of rocuronium (1 mg/kg) (Eslax, MSD Co. Ltd. Read More

Vox Sang 2019 Apr 2. Epub 2019 Apr 2.

Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, McMaster University, Hamilton, ON, Canada.

Background And Objectives: Rare but potentially life-threatening hypersensitivity reactions can occur during the administration of intravenous iron. To provide guidance to healthcare professionals caring for adults receiving intravenous iron, a panel of 10 Canadian clinical experts developed a practical algorithm for the identification and management of hypersensitivity reactions to intravenous iron.

Materials And Methods: A systematic search of PubMed to February 2018 was performed. Read More