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Allergy Asthma Proc 2022 Jul 1. Epub 2022 Jul 1.

Introduction: This study aimed to evaluate the preliminary diagnosis, demographic characteristics, and outcomes of patients whose serum total tryptase levels were measured while in a tertiary pediatric hospital and to ascertain the role of serum tryptase levels in the etiology, diagnosis, severity, and course of systemic anaphylaxis.

Methods: Patients ages between 1 month and 17 years who were followed up in the pediatric emergency department or as inpatients and with a diagnosis of immediate-type reactions between September 1, 2019, and August 31, 2021, were includedin the study. Patient data were obtained retrospectively by examination of medical records and patient observation forms. Read More

Ann Clin Lab Sci 2022 May;52(3):382-390

Department of Regenerative Medicine, Kanazawa Medical University, Uchinada, Japan.

Objective: Among transfusion-associated adverse reactions, allergic transfusion reactions (ATRs) and febrile non-hemolytic transfusion reactions (FNHTRs) have a particularly high incidence. However, details of their occurrence time and related clinical factors are unknown; this was this study's aim.

Methods: This was a retrospective study. Read More

HeartRhythm Case Rep 2022 Jun 6;8(6):453-457. Epub 2022 Apr 6.

Department of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota.

Allergy 2022 Jul;77(7):2268

Department of Life Sciences and Public Health, Post-Graduate School of Pediatrics, Policlinico Gemelli Universitary Foundation IRCCS, Catholic University of Sacre Hearth, Rome, Italy.

J Acupunct Meridian Stud 2021 Jun;14(3):102-109

Department of Biological Sciences, College of Natural Sciences, Kangwon National University, Chuncheon, Republic of Korea.

Background: Bee venom has been used as a therapeutic compound for various human diseases in oriental medicine; however, it can induce anaphylaxis in hypersensitive patients during treatment. Anaphylaxis is an acute allergic reaction that occurs after allergen exposure. IgE is released from immune-related cells such as mast cells and basophils during anaphylaxis. Read More

Front Allergy 2022 14;3:870513. Epub 2022 Apr 14.

Department of Biomedical Sciences, University of North Dakota School of Medicine & Health Sciences, Grand Forks, ND, United States.

The symptoms of food allergies vary significantly between individuals, likely due to genetic determinants. In humans, allergy development is initiated by antigen-presenting cells class II human leukocyte antigen (HLA-II). The HLA-II gene is highly polymorphic, and its allelic variance is thought to influence the susceptibility of individuals to a particular allergen. Read More

Front Allergy 2022 30;3:874772. Epub 2022 Mar 30.

Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Drug hypersensitivity can be an important problem during pharmacological management of various diseases. Patients diagnosed as having a drug allergy usually need to avoid the offending drug, either temporarily or for life. Another way of overcoming a drug allergy is to establish desensitization using the allergen drug itself. Read More

Front Allergy 2022 31;3:851993. Epub 2022 Mar 31.

Mary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States.

There is heterogeneity inherent in the immune responses of individual mice in murine models of food allergy, including anaphylaxis, similar to the clinical heterogeneity observed in humans with food allergies to a defined food. One major driver of this heterogeneity may be differences in the microbiome between sensitized individuals. Our laboratory and others have reported that disruption of the microbiome (dysbiosis) by broad spectrum antibiotics and/or yeast colonization can alter systemic immunity and favor the development of mucosal Type 2 immunity to aeroallergens. Read More

Front Allergy 2022 18;3:908435. Epub 2022 May 18.

Service d'Immunologie, CHU Clermont-Ferrand, Clermont-Ferrand, France.

There are two major clinically described forms of IgE-dependent soy allergy: (i) a primary dietary form, linked to sensitization against soy storage proteins Gly m 5 and Glym 6, and (ii) a form included in birch-soy syndromes linked to Gly m 4, a PR-10-like allergen. This second form sometimes causes severe systemic reactions, even anaphylaxis, especially on consuming certain forms of soy such as soymilks or smoothies. Skin prick tests and specific IgE assays against soy whole extracts lack sensitivity. Read More

Front Allergy 2022 9;3:903161. Epub 2022 Jun 9.

Rochester Regional Health, Rochester, NY, United States.

Penicillin allergy is the most commonly reported drug allergy, while perioperative anaphylaxis is overall rare. This review covers the epidemiology of both penicillin allergy and perioperative anaphylaxis both separately and taken together. Considerations regarding anaphylaxis to penicillin during pregnancy are also discussed, since penicillin is the drug of choice for Group B prophylaxis. Read More

Sci Rep 2022 Jun 29;12(1):10946. Epub 2022 Jun 29.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Severe adverse events (AEs) after COVID-19 vaccination are not well studied in randomized controlled trials (RCTs) due to rarity and short follow-up. To monitor the safety of COVID-19 vaccines ("Pfizer" vaccine dose 1 and 2, "Moderna" vaccine dose 1 and 2, and "Janssen" vaccine single dose) in the U.S. Read More

Rev Med Inst Mex Seguro Soc 2022 May 2;60(3):356-360. Epub 2022 May 2.

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Cuidados Intensivos. Ciudad de México, México.

Background: Ketamine is used in intravenous anesthesia for the maintenance in the general anesthesia. It has characteristics to prevent the difficult of breathing due to bronchospasm, as well as the delivery of histamine associated with asthmatic attack. These effects come from the direct action in the bronchial muscle, as well as from the potentiation of its catecholamines, which is why its use is very controversial, given that there are not enough trials to back it up. Read More

Clin Rheumatol 2022 Jun 28. Epub 2022 Jun 28.

Hospital Córdoba, Córdoba, Córdoba, Argentina.

Background/objective: To evaluate the efficacy and safety of SARS-CoV-2 vaccine in patients with rheumatic and immune-mediated inflammatory diseases (IMIDs) in Argentina: the SAR-CoVAC registry.

Methods: SAR-CoVAC is a national, multicenter, and observational registry. Adult patients with rheumatic or IMIDs vaccinated for SARS-CoV-2 were consecutively included between June 1 and September 17, 2021. Read More

J Allergy Clin Immunol 2022 Jun 24. Epub 2022 Jun 24.

Departments of Medicine , NIAID, National Institutes of Health; Bethesda, Maryland, United States of America; Pathology, Microbiology and Immunology, NIAID, National Institutes of Health; Bethesda, Maryland, United States of America. Electronic address:

Rationale: Much of our understanding of the targets of IgE comes from studies of allergy, though little is known about the natural immunogenic targets seen following parasitic worm infections. The use of human monoclonal antibodies (mAbs) allow for an unbiased, comprehensive characterization of the immunodominant antigens targeted by IgE in conditions (e.g. Read More

Immun Inflamm Dis 2022 Jul;10(7):e668

Institute for Maternal and Child Health IRCCS "Burlo Garofolo", Trieste, Italy.

Background: There are no universally accepted criteria for discontinuing milk oral immunotherapy (MOIT) in patients with persistent cow milk allergy (CMA) and little data are available on predictive risk factors for dropping out from oral immunotherapy (OIT), due to allergic reactions or other reasons.

Methods: We retrospectively reviewed clinical records of patients with persistent severe CMA undergoing MOIT in a tertiary care center hospital to investigate risk factors associated with discontinuation of OIT. Persistent and severe allergy was defined as the history of systemic reactions and any milk protein-specific IgE level >85 kU/ml. Read More

Aust Prescr 2022 Jun 5;45(3):100. Epub 2022 May 5.

Pediatr Allergy Immunol 2022 06;33(6):e13789

Division of Immunology and Allergy, Department of Pediatrics, Toronto, Ontario, Canada.

Clin Exp Immunol 2022 Jun 26. Epub 2022 Jun 26.

St James' Hospital, Dublin, Ireland.

Anaphylaxis is a rare side-effect of Covid-19 vaccines. In order to (a) provide direct advice and reassurance to certain persons with a history of anaphylaxis/complex allergy, in addition to that available in national guidelines, and (b) to provide a medically supervised vaccination, a specialist regional vaccine allergy clinic was established. The main objective was to determine if risk stratification through history can lead to safe COVID-19 vaccination for maximum population coverage. Read More

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany.

Background: Food-dependent exercise-induced wheals, angioedema, and anaphylaxis remain insufficiently characterized.

Objective: We systematically reviewed the literature on clinical manifestations, laboratory investigations, culprit foods, triggering exercise, comorbidities, and treatment outcomes.

Methods: Using predefined search terms and Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) recommendations, we searched three electronic databases to identify relevant literature published before July 2021. Read More

Front Bioeng Biotechnol 2022 7;10:882363. Epub 2022 Jun 7.

Department of Chemistry, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.

Poly (ethylene glycol) (PEG) is a widely used polymer in a variety of consumer products and in medicine. PEGylation refers to the conjugation of PEG to drugs or nanoparticles to increase circulation time and reduce unwanted host responses. PEG is viewed as being well-tolerated, but previous studies have identified anti-PEG antibodies and so-called pseudoallergic reactions in certain individuals. Read More

Vaccines (Basel) 2022 May 25;10(6). Epub 2022 May 25.

Emergency Clinical Hospital for Children "Grigore Alexandrescu", 011743 Bucharest, Romania.

In Romania, health and social workers were prioritized for COVID-19 vaccination. We aimed to describe the vaccine adverse events identified through an active survey (using an electronic questionnaire) conducted among the staff of a pediatric hospital from Bucharest, vaccinated with the mRNA Pfizer-BioNTech vaccine. Data on the frequency and duration of adverse events were collected and analyzed using Microsoft Excel, Epi Info, and MedCalc. Read More

Medicina (Kaunas) 2022 Jun 2;58(6). Epub 2022 Jun 2.

Department of Anesthesiology and Pain Medicine, Gyeongsang National University Changwon Hospital 11, Samjeongja-ro, Seongsan-gu, Changwon-si 51472, Korea.

A 46-year-old woman demonstrated refractory Kounis syndrome (KS) after induction of anesthesia. Despite conventional management of anaphylaxis and advanced cardiac life support, her cardiovascular function continued to deteriorate until she had a cardiac arrest, and after extracorporeal membrane oxygenation (ECMO) therapy, electrical cardiac activity reappeared. A large number of patients with KS-"allergic angina syndrome"-has been known to recover well with vasodilators; however, this patient showed antibiotics-induced refractory KS during general anesthesia. Read More

Int J Mol Sci 2022 Jun 10;23(12). Epub 2022 Jun 10.

Food Allergy & Immunology Laboratory, Department of Food Science & Human Nutrition, Michigan State University, East Lansing, MI 48824, USA.

Wheat allergies are potentially life-threatening because of the high risk of anaphylaxis. Wheats belong to four genotypes represented in thousands of lines and varieties. Monitoring changes to wheat allergens is critical to prevent inadvertent ntroduction of hyper-allergenic varieties via breeding. Read More

Foods 2022 Jun 17;11(12). Epub 2022 Jun 17.

Department of Analytical Chemistry, Nutrition and Bromatology, Santiago de Compostela University, 27002 Lugo, Spain.

The functionality of breast milk in terms of immunity is well-known. Despite this, a significant proportion of breastfed infants exhibit sensitization to different potentially allergenic proteins and clinical reactivity (including anaphylaxis) early in life and before the introduction of complementary feeding for the first time. The potential induction of early oral tolerance to overcome early allergic sensitization through exposure to allergens in breast milk also remains controversial and not yet well-established. Read More

Emerg Med Pract 2022 Jul 1;24(7):1-24. Epub 2022 Jul 1.

Associate Professor of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA.

An acute allergic reaction is a rapid-onset, IgE-mediated hypersensitivity reaction. Although it is most commonly caused by food, insect stings, and medications, there are many additional causes. Symptoms can range from mild urticaria and swelling, to abdominal cramping, to respiratory collapse. Read More

Clin Transl Allergy 2022 Jun 15;12(6):e12166. Epub 2022 Jun 15.

Service de pneumologie A APHP Hôpital Bichat Paris France.

Allergo J Int 2022 Jun 14:1-14. Epub 2022 Jun 14.

Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.

Anaphylaxis in connection with the administration of vaccines occurs only very rarely. Triggers of immunoglobulin IgE-mediated and non-IgE-mediated anaphylaxis-in addition to the active ingredient itself-may be excipients contained in the vaccine due to their special properties. Some of the excipients in medicinal products are the same compounds used as additives in food. Read More

J Clin Pharmacol 2022 Jun 21. Epub 2022 Jun 21.

Department of Pharmacy, Okayama Saiseikai General Hospital, Okayama, Japan.

BMJ 2021 06 14;373:n1435. Epub 2021 Jun 14.

Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford, UK

Objective: To quantify the background incidence rates of 15 prespecified adverse events of special interest (AESIs) associated with covid-19 vaccines.

Design: Multinational network cohort study.

Setting: Electronic health records and health claims data from eight countries: Australia, France, Germany, Japan, the Netherlands, Spain, the United Kingdom, and the United States, mapped to a common data model. Read More

PLoS Med 2022 Jun 21;19(6):e1004018. Epub 2022 Jun 21.

Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.

Background: Safety monitoring of coronavirus disease 2019 (COVID-19) vaccines is crucial during mass vaccination rollout to inform the choice of vaccines and reduce vaccine hesitancy. Considering the scant evidence directly comparing the safety profiles of mRNA and inactivated SARS-CoV-2 vaccines, this territory-wide cohort study aims to compare the incidence of various adverse events of special interest (AESIs) and all-cause mortality between CoronaVac (inactivated vaccine) and BNT162b2 (mRNA-based vaccine). Our results can help vaccine recipients make an informed choice. Read More