28,717 results match your criteria Anaphylaxis


Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma.

Respir Physiol Neurobiol 2018 Dec 3. Epub 2018 Dec 3.

R.C. Patel Institute of Pharmaceutical Education & Research, Shirpur, Dhule, 425405, India.

Zizyphus jujuba Mill, a famous oriental traditional medicine, has been reported to exhibit diverse activities in biological systems including the respiratory system. However, a little information is available on its antiasthmatic activity. Jujuboside B (JB) is a natural saponin and one of the active constituent of fruits of Zizyphus jujuba. Read More

View Article
December 2018
1 Read

Anaphylaxis to intravenous gelatin-based solutions: a case series examining clinical features and severity.

Anaesthesia 2018 Dec 5. Epub 2018 Dec 5.

Department of Anaesthesia and Peri-operative Medicine, Monash University, Melbourne, Vic., Australia.

The proportion of patients receiving intravenous gelatin-based colloids has increased in the last decade due to safety concerns about starch-based products. Recent research suggests hypersensitivity reactions to intravenous gelatin-based solutions occur at similar rates per administration as non-depolarising neuromuscular blocking agents such as rocuronium (6.2/100,000 administrations). Read More

View Article
December 2018
2 Reads

Rush desensitization with a single antigen induces subclinical activation of mast cells and protects against bystander challenge in dually sensitized mice.

Clin Exp Allergy 2018 Dec 2. Epub 2018 Dec 2.

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, United States.

Background: Rush desensitization can provide short-term tolerance to individuals who are allergic to certain medications in instances where other therapeutic interventions are limited. While rush DS is typically successful in preventing adverse type I hypersensitivity reactions, the mechanism of allergic protection remains unknown. Given the rise in prevalence of individuals displaying multiple allergies, understanding the impact of rush DS on "bystander" allergens, or additional allergens to which an individual is sensitized, could help inform clinical recommendations. Read More

View Article
December 2018

Chemically modified peanut extract shows increased safety while maintaining immunogenicity.

Allergy 2018 Dec 2. Epub 2018 Dec 2.

Institute for Risk Assessment Sciences, Immunotoxicology, Utrecht University, Utrecht, The Netherlands.

Background: Peanuts are most responsible for food-induced anaphylaxis in adults in developed countries. An effective and safe immunotherapy is urgently needed. The aim of this study was to investigate the immunogenicity, allergenicity and immunotherapeutic efficacy of a well characterized chemically modified peanut extract (MPE) adsorbed to Al(OH) . Read More

View Article
December 2018

Causal relationship between immunological responses and adverse reactions following vaccination.

Authors:
Tetsuo Nakayama

Vaccine 2018 Nov 29. Epub 2018 Nov 29.

Kitasato Institute for Life Sciences, Laboratory of Viral Infection, 5-9-1 Shirokane Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Vaccine adverse events and controversial safety issues have occurred in recent decades in Japan: aseptic meningitis following the measles-mumps-rubella combined vaccine (MMR), anaphylaxis after immunization with live virus vaccines and inactivated split influenza vaccine, an increased incidence of febrile illness following the simultaneous administration of inactivated vaccines, and chronic pain with neurological illness after immunization with the human papilloma virus vaccine (HPV). Vaccine adverse events are a matter of concern for the public as well as general practitioners; some are within the range of assumptions that adverse reactions after live attenuated vaccines are related to the nature of their parental wild-type viruses. Vaccines stimulate the innate immunity of host immunological defense mechanisms and induce the development of specific acquired immunity. Read More

View Article
November 2018

Prevention of rocuronium induced mast cell activation with prophylactic oleuropein rich diet in anesthetized rabbits1.

Acta Cir Bras 2018 Nov;33(11):954-963

Assistant Professor, Department of Anesthesiology and Reanimation, Medical Faculty, Canakkale Onsekiz Mart University, Turkey. Analysis and interpretation of data.

Purpose: The effect of a prophylactic oleuropein-rich diet before anesthesia accompanied by the widely-used steroid-based neuromuscular drug rocuronium on mast cell activation was investigated in the study.

Methods: 14 rabbits used in the study. The rabbits in the oleuropein group were given oleuropein-rich extract added to the animals' water at doses of 20 mg/kg oleuropein for 15 days orally. Read More

View Article
November 2018
1 Read

[Personalized medicine in allergology].

Hautarzt 2018 Dec 4. Epub 2018 Dec 4.

Klinik für Dermatologie und Allergologie, Allergie Zentrum Hessen, Universitätsklinikum Gießen und Marburg, Standort Marburg, Philipps-Universität Marburg, Baldinger Str., 35043, Marburg, Deutschland.

Background: Personalized medicine offers new perspectives for diagnostic measurements and medical treatment, but also puts greater demands on the physician.

Objectives: Developments, potentials and potential pitfalls of personalized medicine in allergology.

Methods: Overview, evaluation and discussion of the current state of science on the basis of selected examples. Read More

View Article
December 2018

The Use of Epinephrine for Out-Of-Hospital Treatment of Anaphylaxis.

Authors:

Prehosp Emerg Care 2018 Dec 4. Epub 2018 Dec 4.

View Article
December 2018
1 Read

Provocation Test-Confirmed Chlorhexidine-Induced Anaphylaxis in Dental Procedure.

Chin Med J (Engl) 2018 Dec;131(23):2893-2894

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

View Article
December 2018
4 Reads

Inherent allergic potential of α-dioxygenase fragment: A pathogenesis related protein.

Immunobiology 2018 Nov 15. Epub 2018 Nov 15.

Food Toxicology Laboratory, Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR campus Lucknow, India. Electronic address:

In the course of analyzing amino acid sequence of an allergen (≈20 kDa), we found this protein has a homology with the amino acid sequence of putative α-Dioxygenase fragment (ADF). Allergy caused by many allergens having an enzymatic activity have been reported previously, but allergenicity to neither α-Dioxygenase enzyme nor to it's any constituents has been reported. We sought to purify an ADF (≈19. Read More

View Article
November 2018
2 Reads
3.044 Impact Factor

Anaphylactic shock with methylprednisolone, Kounis syndrome and hypersensitivity to corticosteroids: a clinical paradox.

Ital J Pediatr 2018 Nov 28;44(1):143. Epub 2018 Nov 28.

Krankenhaus der Barmherzigen Brüder, Trier, Germany.

Corticosteroids are widely used for the treatment of allergic reactions but paradoxically themselves may induce acute, delayed, local or systemic allergic reactions and even anaphylaxis with Kounis syndrome. They can suppress the release of arachidonic acid from mast cell membranes, via phospholipase A2 and eicosanoid biosynthesis inhibition. Corticosteroids can promote cell apoptosis and mediate in annexin or lipocortin synthesis, substances that modulate inflammatory cell activation, adhesion molecule expression, transmigratory and phagocytic functions. Read More

View Article
November 2018

Anaesthetic implications of a patient with cold-induced anaphylaxis presenting to the labour ward.

Int J Obstet Anesth 2018 Sep 26. Epub 2018 Sep 26.

Chelsea and Westminster Hospital, Magill Department of Anaesthesia, London, United Kingdom.

Cold contact urticaria is a well described condition, with reactions ranging from localised wheals to systemic and anaphylactic reactions. Case reports involving anaesthetic care are rare. This report describes a patient with cold-induced urticaria with systemic reactions who had been advised to carry an adrenaline autoinjector. Read More

View Article
September 2018
1 Read

Successful oral desensitization in children with cow's milk anaphylaxis: Clinical and laboratory evaluation up to nine-years follow-up.

Allergol Immunopathol (Madr) 2018 Oct 25. Epub 2018 Oct 25.

Immunoallergy Department, CUF Descobertas Hospital, Lisbon, Portugal.

Introduction: Cow's milk protein allergy (CMPA) is the most common food allergy in children worldwide. Some children have severe and persistent CMPA, with near-fatal reactions after exposure to trace amounts of cow's milk-proteins (CMP). Strict avoidance diet is difficult, negatively affects quality of life and represents a conservative approach. Read More

View Article
October 2018

Ammonia Inhalation Does Not Increase Deadlift 1-Repetition Maximum in College-Aged Male and Female Weight Lifters.

J Strength Cond Res 2018 Dec;32(12):3383-3388

Department of Human Movement Sciences, Old Dominion University, Norfolk, Virginia.

Vigil, JN, Sabatini, PL, Hill, LC, Swain, DP, and Branch, JD. Ammonia inhalation does not increase deadlift 1-repetition maximum in college-aged male and female weight lifters. J Strength Cond Res 32(12): 3392-3397, 2018-Ammonia inhalant use by powerlifters and weight lifters is a prevalent practice with little research support for improved performance. Read More

View Article
December 2018
1 Read

Mugwort Pollen-Related Food Allergy: Lipid Transfer Protein Sensitization and Correlation With the Severity of Allergic Reactions in a Chinese Population.

Authors:
Shan Deng Jia Yin

Allergy Asthma Immunol Res 2019 Jan;11(1):116-128

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Purpose: Little is known about the importance of lipid transfer protein (LTP) sensitization in China. In this study, we investigated the relationship between LTP sensitization and the severity of clinical symptoms in a population of patients with mugwort pollen-related food allergy.

Methods: Food-induced symptoms were evaluated in 148 patients with mugwort pollen allergy by a standardized questionnaire. Read More

View Article
January 2019
1 Read

Drug-Induced Anaphylaxis in a Vietnamese Pharmacovigilance Database: Trends and Specific Signals from a Disproportionality Analysis.

Drug Saf 2018 Nov 27. Epub 2018 Nov 27.

Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine de l'Université Paul-Sabatier (Medical and Clinical Pharmacology Laboratory, Faculty of Medicine, Paul-Sabatier University) and Centre Hospitalier Universitaire de Toulouse (Toulouse University Hospital Centre), Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d'Information sur le Médicament (Midi-Pyrenees Centre for Pharmacovigilance, Pharmacoepidemiology and Drug Information), UMR INSERM 1027, Toulouse, France.

Introduction: Despite the numerous studies investigating drug-induced anaphylaxis (DIA), understanding and quantitative data analysis in developing countries remain limited. The aim of our study is to describe and quantify DIA using the National Pharmacovigilance Database of Vietnam (NPDV).

Methods: Spontaneous reporting of adverse drug reactions (ADRs) recorded between 2010 and 2016 were retrospectively analysed to identify DIA reports. Read More

View Article
November 2018
6 Reads

Emergency Management of Anaphylaxis due to an Unknown Trigger: An 8-year follow-up study in Canada.

J Allergy Clin Immunol Pract 2018 Nov 23. Epub 2018 Nov 23.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, Montreal, QC Canada.

Background: Anaphylaxis due to Unknown Trigger (AUT) is anaphylaxis not explained by a proved or presumptive cause or stimulus at the time of the reaction. Research describing the management and follow-up of AUT is limited.

Objective: This study assesses and compares the demographics, clinical characteristics and management of adult and pediatric AUT cases across Canada. Read More

View Article
November 2018
1 Read

Identification of the minimal region of peptide derived from ADP-ribosylation factor1 (ARF1) that inhibits IgE-mediated mast cell activation.

Mol Immunol 2018 Nov 22;105:32-37. Epub 2018 Nov 22.

Laboratory of Immune Regulation, Graduate School of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3 Minamitamagaki, Suzuka, Mie 513-8607, Japan; Laboratory of Immune Regulation, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3 Minamitamagaki-cho, Suzuka, Mie 513-8670, Japan. Electronic address:

Mast cells play a pivotal role in allergic reactions and inflammations. Aggregation of the high affinity IgE receptor (FcεRI) eventually leads to the release of granule components such as histamine, as well as the de novo synthesis of inflammatory cytokines and lipid mediators. These substances are involved in the development of allergy and inflammation. Read More

View Article
November 2018
3 Reads

Managing Cross-Reactivity in Those with Peanut Allergy.

J Allergy Clin Immunol Pract 2018 Nov 22. Epub 2018 Nov 22.

Department of Child and Adolescent, Medical School of the University of Geneva, University Hospitals of Geneva, Geneva, Switzerland.

Peanut is an allergenic legume that can cross-react with other plant-based foods, notably other legumes and tree nuts. Peanut allergic individuals can be both co-sensitized as well as co-allergic to such items, requiring foresight when eliciting a clinical history of reaction, in the diagnostic evaluation of such allergies, and in the counseling of patients as to food avoidances after a diagnosis is made. Legume allergens belong to the Fabaceae family and encompass the cupin, prolamin, PR-10, and LTP families, which mediate cross-sensitization including that between peanut and tree nut. Read More

View Article
November 2018
7 Reads

Fish-allergic patients tolerate ray based on the low allergenicity of its parvalbumin.

J Allergy Clin Immunol Pract 2018 Nov 21. Epub 2018 Nov 21.

Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.

Background: Clinical reactions to bony fish species are common in fish-allergic patients and caused by parvalbumins of the β-lineage. Cartilaginous fish such as rays and sharks contain mainly α-parvalbumins and their allergenicity is not well understood.

Objective: We investigated the allergenicity of cartilaginous fish and their α-parvalbumins in individuals allergic to bony fish. Read More

View Article
November 2018
4 Reads

The Mechanistic Impact of N-Glycosylation on Stability, Pharmacokinetics and Immunogenicity of Therapeutic Proteins.

Authors:
Qun Zhou Huawei Qiu

J Pharm Sci 2018 Nov 21. Epub 2018 Nov 21.

Biologics Research Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.

N-glycosylation is one of major post-translational modifications in nature and it is essential for protein structure and function. As hydrophilic moieties of glycoproteins, N-glycans play important roles in protein stability. They protect the proteins against proteolytic degradation, aggregation and thermal denaturation through maintaining optimal conformations. Read More

View Article
November 2018
5 Reads

Cyclical Hypersensitivity, Anaphylaxis and Related Hormonal Reaction.

Ann Allergy Asthma Immunol 2018 Nov 20. Epub 2018 Nov 20.

View Article
November 2018
1 Read

Component-resolved diagnosis (CRD) of food anaphylaxis

Folia Med Cracov 2018 ;58(2):97-106

Department of Clinical and Environmental Allergology, Faculty of Medicine Jagiellonian University Medical College, Śniadeckich 10, Kraków, Poland.

Anaphylaxis is an increasing problem in public health. The food allergens (mainly milk, eggs, and peanuts) are the most frequent cause of anaphylaxis in children and youth. In order to define the cause of anaphylaxis, skin tests, the determination of the concentration of specific IgE in the blood and basophil activation test are conducted. Read More

View Article
January 2018
4 Reads

"Drug Allergy in children and adults: is it the double X chromosome?"

Ann Allergy Asthma Immunol 2018 Nov 19. Epub 2018 Nov 19.

Boston Children's Hospital, Division of Allergy and Immunology, Harvard Medical School, Boston, MA; Harvard Medical School. Electronic address:

View Article
November 2018
2 Reads

Allergic acute coronary syndrome in exercise-induced anaphylaxis.

Neth J Med 2018 Nov;76(9):411-414

Departments of Acute Care, Erasmus Medical Center, Rotterdam, the Netherlands.

In this case report we present a 49-year-old male who was seen in the emergency department after collapsing due to anaphylactic shock, with ECG findings suggesting myocardial ischaemia. We linked both diagnoses to Kounis syndrome, which describes an acute coronary syndrome due to an allergic event. His circulatory collapse was explained by exercise-induced anaphylaxis. Read More

View Article
November 2018
4 Reads

Towards reducing the immunogenic potential of wheat flour: omega gliadins encoded by the D genome of hexaploid wheat may also harbor epitopes for the serious food allergy WDEIA.

BMC Plant Biol 2018 Nov 21;18(1):291. Epub 2018 Nov 21.

National Institute of Agricultural Sciences, RDA, Jeonju, 54874, South Korea.

Background: Omega-5 gliadins are a group of highly repetitive gluten proteins in wheat flour encoded on the 1B chromosome of hexaploid wheat. These proteins are the major sensitizing allergens in a severe form of food allergy called wheat-dependent exercise-induced anaphylaxis (WDEIA). The elimination of omega-5 gliadins from wheat flour through biotechnology or breeding approaches could reduce the immunogenic potential and adverse health effects of the flour. Read More

View Article
November 2018
3 Reads

Simulation as a learning method in public health nurse education.

Public Health Nurs 2018 Nov 20. Epub 2018 Nov 20.

Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU (Norwegian University of Science and Technology), Trondheim, Norway.

Objective: To view simulation as a learning method in the light of learning theories and to describe the student's reflections and experiences of simulating anaphylaxis during vaccination.

Design And Sample: Public health nursing students at a university in Norway simulated scenarios related to anaphylaxis during vaccination of an infant. The aim of the intervention was to facilitate the competence of public health nurses to handle unforeseen events associated with vaccinations. Read More

View Article
November 2018
6 Reads

Human Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Atopic Dermatitis by Regulating the Expression of MIP-2, miR-122a-SOCS1 Axis, and Th1/Th2 Responses.

Front Pharmacol 2018 6;9:1175. Epub 2018 Nov 6.

Department of Biochemistry, Kangwon National University, Chunchon, South Korea.

The objective of this study was to investigate the effect of human adipose tissue-derived mesenchymal stem cells (AdMSCs) on atopic dermatitis (AD) in the BALB/c mouse model. The AdMSCs attenuated clinical symptoms associated with AD, decreased numbers of degranulated mast cells (MCs), IgE level, amount of histamine released, and prostaglandin E2 level. Atopic dermatitis increased the expression levels of cytokines/chemokines, such as interleukin-5 (IL-5), macrophage inflammatory protein-1ß (MIP-1ß), MIP-2, chemokine (C-C motif) ligand 5 (CCL5), and IL-17, in BALB/c mouse. Read More

View Article
November 2018
8 Reads

Anaphylaxis with midazolam in pediatric hematology-oncology unit: a case report.

Turk Pediatri Ars 2018 Sep 1;53(3):200-201. Epub 2018 Sep 1.

Department of Pediatric Hematology and Oncology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.

View Article
September 2018
3 Reads

Comparison of practical application steps of the previously used adrenaline auto injector in Turkey (EpiPen) and the currently available adrenaline auto injector (Penepin): a multi-center study.

Turk Pediatri Ars 2018 Sep 1;53(3):149-154. Epub 2018 Sep 1.

Department of Pediatrics, Division of Pediatric Allergy and Asthma, Gazi University School of Medicine, Ankara, Turkey.

Aim: It has been shown by a great number of studies that the correct use of adrenaline auto injectors prescribed to patients with anaphylaxis is associated with the design of the auto injector, in addition to training. The aim of this study was to compare the skills of adults in using two different auto injectors prescribed to patients with anaphylaxis.

Material And Methods: Parents of patients aged between 1 and 18 years who referred to allergy outpatients were included in the study. Read More

View Article
September 2018
1 Read

Transcriptional profiling of dendritic cells in a mouse model of food-antigen induced anaphylaxis reveals the upregulation of multiple immune-related pathways.

Mol Nutr Food Res 2018 Nov 20:e1800759. Epub 2018 Nov 20.

Research laboratory, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.

Scope: Much of our knowledge about gene expression during anaphylaxis comes from candidate gene studies. Despite their potential role, expression changes in dendritic cells (DCs) have not been studied in this context using high throughput methods. We investigated the molecular mechanisms underlying food-antigen induced anaphylaxis using DCs from an animal model. Read More

View Article
November 2018
9 Reads

Seongsanamides A-D: Antiallergic Bicyclic Peptides from Bacillus safensis KCTC 12796BP.

Org Lett 2018 Nov 20. Epub 2018 Nov 20.

College of Pharmacy , Yeungnam University , Gyeongbuk 38541 , Republic of Korea.

Six seongsanamides were isolated from the culture broth of Bacillus safensis KCTC 12796BP, and their structures were elucidated by spectroscopic data analysis combined with Marfey's method, electronic circular dichroism calculations, and biosynthetic gene cluster analysis. Compounds 1-4 were bicyclic peptides with isodityrosine residues; 5 and 6 were monocyclic peptides. Only the bicyclic seongsanamides inhibited degranulation and LTC/PGD generation in IgE/Ag-stimulated bone marrow-derived mast cells. Read More

View Article
November 2018
1 Read

Aetiology of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka.

Allergy Asthma Clin Immunol 2018 8;14:81. Epub 2018 Nov 8.

3Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Colombo, Sri Lanka.

Background: The aetiology of anaphylaxis differs according to types of foods consumed, fauna and foliage and cultural practices. Although the aetiology of anaphylaxis in Western countries are well known, the causes in South Asian countries have not been reported. We sought to determine the causes of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka. Read More

View Article
November 2018
2 Reads

Acute respiratory distress syndrome after the use of gadolinium contrast agent.

Respir Med Case Rep 2018 24;25:336-338. Epub 2018 Oct 24.

Department of Pulmonary Diseases, Ataturk University, School of Medicine, 25240, Erzurum, Turkey.

Acute respiratory distress syndrome (ARDS) is a life-threatening medical emergency. The etiology of ARDS can involve various causes. ARDS associated with the use of iodinated contrast media is rarely reported, and the literature includes only one case of ARDS due to gadobutrol. Read More

View Article
October 2018
5 Reads

Evaluation of the Potential Risk Factors for Drug-Induced Anaphylaxis in Adult Patients.

Int Arch Allergy Immunol 2018 Nov 16:1-10. Epub 2018 Nov 16.

Division of Immunology and Allergic Diseases, Department of Internal Medicine, Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Aim: To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs.

Method: The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. Read More

View Article
November 2018
4 Reads

Acquired Donor Peanut Allergy From Lung Transplantation Resulting in Respiratory Failure: A Case Report.

Transplant Proc 2018 Aug 9. Epub 2018 Aug 9.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California-San Diego, San Diego, California.

This case report describes a patient who acquired a donor peanut allergy after lung transplantation. A 53-year-old woman with alpha-1 antitrypsin deficiency underwent left-sided lung transplant from a donor with a history of anaphylaxis to peanut. Two weeks after the transplant, the patient developed acute respiratory failure immediately after consuming a peanut butter and jelly sandwich. Read More

View Article
August 2018
2 Reads

Epinephrine (adrenaline) preventing recovery from intraoperative anaphylactic shock complicated by systolic anterior motion of the mitral valve with left ventricular outflow tract obstruction on transoesophageal echocardiography.

Anaesth Intensive Care 2018 Nov;46(6):566-571

Clinician, WA Anaesthetic Allergy Clinic; Perth, Western Australia.

We describe a case of severe left ventricular outflow tract obstruction (LVOTO) with severe mitral incompetence due to systolic anterior motion of the anterior mitral leaflet (SAM) that was recognised thanks to the immediate availability of transoesophageal echocardiography during the resuscitation of anaphylactic shock. The patient rapidly responded to cessation of the epinephrine (adrenaline) infusion and intravascular volume expansion with intravenous crystalloid. The absence of risk factors for developing SAM/LVOTO serve as a warning to clinicians to consider this diagnosis in all cases of epinephrine non-responsive anaphylactic shock. Read More

View Article
November 2018
2 Reads

Accuracy of in-house alcohol-dissolved wheat extract for diagnosing IgE-mediated wheat allergy.

Asian Pac J Allergy Immunol 2018 Oct 15. Epub 2018 Oct 15.

Samitivej Allergy Institute, Samitivej Thonburi Hospital, Thonburi, Bangkok, Thailand.

Background: The standard method for diagnosing immediate wheat allergy is oral food challenge test (OFC). However, OFC can provoke anaphylaxis during the challenge process. Skin prick test (SPT) using commercial wheat extract yielded unsatisfactory result for diagnosis of wheat allergy. Read More

View Article
October 2018
4 Reads

Anaphylaxis: Ten-year retrospective study from a tertiary-care hospital in Northern Thailand.

Asian Pac J Allergy Immunol 2018 Oct 15. Epub 2018 Oct 15.

Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: The study of anaphylaxis in different geographic areas raises the awareness to improve prevention and medical care.

Objective: To investigate the incidence, causes, characteristics, and management of anaphylaxis in Chiang Mai, Thailand METHODS: We performed a retrospective review, based on ICD-10 electronic medical records of patients who attended the Out-Patient and Emergency Departments at Chiang Mai University Hospital from January 2007 to December 2016.

Results: A total of 441 episodes of anaphylaxis in 433 patients were analyzed. Read More

View Article
October 2018
1 Read

Guideline review: Epinephrine use in anaphylaxis (AAP guideline 2017).

Authors:
Nicola Goodall

Arch Dis Child Educ Pract Ed 2018 Nov 15. Epub 2018 Nov 15.

Department of Paediatrics, Northumbria Healthcare NHS Foundation Trust, Newcastle, UK.

View Article
November 2018
11 Reads

An ounce of caution: Superparamagnetic iron oxide nanoparticle based magnetic resonance imaging contrast-associated anaphylaxis.

Ann Allergy Asthma Immunol 2018 Nov 13. Epub 2018 Nov 13.

Department of Critical Care, Mayo Clinic, Jacksonville, Florida.

View Article
November 2018
2 Reads
2.599 Impact Factor

Mast Cell CRF Suppresses Mast Cell Degranulation and Limits the Severity of Anaphylaxis and Stress-Induced Intestinal Permeability.

J Allergy Clin Immunol 2018 Nov 12. Epub 2018 Nov 12.

Gastrointestinal Stress Biology Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA; Department of Physiology, Michigan State University. Electronic address:

Background: Psychological stress and heightened MC activation are linked with important immunological disorders including allergy, anaphylaxis, asthma, and functional bowel diseases, but the mechanisms remain poorly defined. We have previously demonstrated that activation of the corticotropin releasing factor (CRF) system potentiates MC degranulation responses during IgE-mediated anaphylaxis and psychological stress, via CRF receptor subtype 1 (CRF) expressed on MCs.

Objective: In this study, we investigated the role of CRF receptor subtype 2 (CRF) as a modulator of stress-induced MC degranulation and associated disease pathophysiology. Read More

View Article
November 2018
3 Reads

Management of peanut allergy: a focus on novel immunotherapies.

Am J Manag Care 2018 Oct;24(19 Suppl):S419-S427

Assistant Professor of Pediatrics and Internal Medicine, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, TX. Email:

The management of peanut allergy involves strict avoidance, prompt recognition of allergic reactions, and rapid initiation of epinephrine and other supportive therapy for anaphylaxis. Avoidance presents several challenges and burdens to quality of life and daily activities. Currently, no treatment options are available for peanut allergy apart from epinephrine, which is the treatment of choice for severe allergic reactions. Read More

View Article
October 2018
17 Reads

Immediate hypersensitivity to p-phenylenediamine.

Contact Dermatitis 2018 Nov 13. Epub 2018 Nov 13.

Coty Inc., Department of Toxicology, Darmstadt, Germany.

View Article
November 2018
1 Read

Anaphylaxis in atypical cold urticaria: case report and review of literature.

Ital J Pediatr 2018 Nov 13;44(1):135. Epub 2018 Nov 13.

Institute for Maternal and Child Health IRCCS "Burlo Garofolo", 34137, Trieste, Italy.

Background: Cold-induced urticaria is a kind of physical urticaria characterized by the appearance of wheals after exposure to cold. The atypical form is a rare sub-type characterized by appearance of hives even in areas not directly exposed to the cold and by a negative cold stimulation test. Its diagnosis is often challenging because of the lack of specific tests and it is usually based on the patient's clinical history. Read More

View Article
November 2018
5 Reads

Action Plan to Reach the Global Availability of Adrenaline Auto-Injectors.

J Investig Allergol Clin Immunol 2018 Nov 13. Epub 2018 Nov 13.

University Hospital of Montpellier and Sorbonne Universités. France.

Adrenaline is the first-line treatment for anaphylaxis and, therefore, listed as an essential medication for the treatment of anaphylaxis by the World Health Organization (WHO). However, the availability of auto-injector (AAI) forms for use in the first-aid treatment is limited to only 32% of all 195-world countries, mostly high-income countries. The key issues leading to the lack of availability of AAIs include cost but also national regulations, lack of regional evidence about the value of epinephrine and the limited accurate data about the epidemiology of anaphylaxis. Read More

View Article
November 2018
4 Reads

Critically appraised topic on adverse food reactions of companion animals (6): prevalence of noncutaneous manifestations of adverse food reactions in dogs and cats.

BMC Vet Res 2018 Nov 12;14(1):341. Epub 2018 Nov 12.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.

Background: Many reports describe the cutaneous signs of adverse food reactions (AFR) in the dog and cat. However, various non-cutaneous clinical signs are less well described. Our objective was to systematically evaluate these non-cutaneous signs of AFR in small animals. Read More

View Article
November 2018
5 Reads

Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients.

Allergy 2018 Nov 12. Epub 2018 Nov 12.

Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: Histaminolytic activity mediated by diamine oxidase (DAO) is present in plasma after induction of severe anaphylaxis in rats, guinea pigs and rabbits. Heparin released during mast cell degranulation in the gastrointestinal tract might liberate DAO from heparin-sensitive storage sites. DAO release during anaphylaxis has not been demonstrated in humans. Read More

View Article
November 2018
4 Reads