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Cochrane Database Syst Rev 2020 Jul 10;7:CD013600. Epub 2020 Jul 10.

Cochrane Cancer, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: Convalescent plasma and hyperimmune immunoglobulin may reduce mortality in patients with viral respiratory diseases, and are currently being investigated in trials as potential therapy for coronavirus disease 2019 (COVID-19). A thorough understanding of the current body of evidence regarding the benefits and risks is required.  OBJECTIVES: To continually assess, as more evidence becomes available, whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in treatment of people with COVID-19. Read More

Balkan Med J 2020 Jul 10. Epub 2020 Jul 10.

Department of Pediatrics, Ege University School of Medicine, İzmir, Turkey.

Background: Oral immunotherapy (OIT) for cow's milk allergy (CMA) is an effective treatment option on the basis of its ability to increase the threshold for clinical reactions.

Aim: We aimed to present our experience of OIT with CM at a pediatric allergy outpatient clinic and to evaluate risk factors for the development of adverse reactions during OIT and to show the long-term effectiveness of OIT.

Study Design: Single-center retrospective cohort study. Read More

Zhongguo Zhen Jiu 2020 Jul;40(7):765-70

Graduate School, Liaoning University of TCM, Shenyang 110032, China.

Objective: To observe the effect of electroacupuncture (EA) preconditioning on the expressions of tyrosine kinase Lyn and spleen tyrosine kinase (Syk) in mast cells of subcutaneous loose connective tissue in the rats with urticaria and explore the potential biological mechanism of EA in the intervention of urticaria.

Methods: A total of 32 SD rats were randomized into a blank group, a model group, an EA group and a positive medication group, 8 rats in each one. Except of the blank group, the passive cutaneous anaphylaxis (PCA) was adopted to prepare the model of urticaria in the rats of the rest three groups. Read More

Cell Rep 2020 Jul;32(1):107848

Experimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark; Immunology and Genetics, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg. Electronic address:

Immunotherapy shifted the paradigm of cancer treatment. The clinical approval of immune checkpoint blockade and adoptive cell transfer led to considerable success in several tumor types. However, for a significant number of patients, these therapies have proven ineffective. Read More

Pharmazie 2020 Jul;75(7):339-343

Laboratory of Pharmacology, Kobe Pharmaceutical University, Kobe, Japan.

The aim of this study was to evaluate the anti-anaphylactic and anti-allergic potentials of saracatinib, a Src family kinase inhibitor that was already shown to be safe in clinical trials when it was used as an anti-cancer drug. Using mast cell models, we found that saracatinib inhibited the degranulation response and cytokine production in RBL2H3 cells that were stimulated with IgE and antigen without affecting cell viability. Phosphorylation of Lyn, Akt, a PI3K substrate, and MAPKs including ERK, JNK, and p38, as well as the intracellular Ca increase induced by this stimulation were also suppressed by saracatinib. Read More

Expert Rev Mol Diagn 2020 Jul 5. Epub 2020 Jul 5.

SaBio. Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM , Ronda de Toledo s/n, 13005 Ciudad Real, Spain.

Introduction: The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody response against the carbohydrate Galα1-3Galβ1-4GlcNAc-R (α-Gal). Tick bites are recognized as the most important cause of anti-α-Gal IgE antibody increase in humans. Several risk factors have been associated with the development of AGS, but their integration into a standardized disease diagnosis has proven challenging. Read More

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(12):2865-2871

Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bioengineering,Beijing University of Technology Beijing 100124, China.

This paper was aimed to establish a new method for evaluating the anaphylactoid reaction of 15 batches of Zushima Injection from different manufacturers in vitro. Basophilic leukemia cell line RBL-2 H3 cells were cultured in vitro and Compound 48/80 was selected as positive drug. Real-time cell analysis(RTCA) system was used to detect the changes of cell index(CI) value after drug intervention. Read More

Int J Med Inform 2020 Jun 17;141:104219. Epub 2020 Jun 17.

Department of General Medicine, Royal Children's Hospital, Parkville, Australia; EMR Project, Royal Children's Hospital, 50 Flemington Rd, Parkville, Australia; Department of Paediatrics, University of Melbourne, Carlton, Australia; Murdoch Children's Research Institute, Parkville, Australia. Electronic address:

Background: Individualised Action Plans (APs) are a key management tool for paediatric asthma, allergy, anaphylaxis and eczema. They provide salient care instructions for patients and caregivers and are thought to improve disease outcomes, albeit with minimal supporting evidence. Whilst the provision of an AP has become a widely measured healthcare quality marker, the content of the plans provided has been relatively neglected. Read More

Br J Anaesth 2020 Jul 2. Epub 2020 Jul 2.

Toon City, Ehime, Japan.

J Allergy Clin Immunol Pract 2020 Jul - Aug;8(7):2458-2459

Faculty of Medicine and Health Science, Department of Immunology - Allergology - Rheumatology and the Infla-Med Consortium of Excellence, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium; Department of Immunology - Allergology, AZ Jan Palfijn Gent, Ghent, Belgium.

J Allergy Clin Immunol Pract 2020 Jul - Aug;8(7):2457-2458

Intensive Care Unit, Gunma University Hospital, Gunma, Japan. Electronic address:

J Allergy Clin Immunol Pract 2020 Jul - Aug;8(7):2209-2214

Division of Medicine, Academy of Medicine of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Exercising is both pleasant and healthy. In some individuals, it can trigger adverse reactions. Examples of these reactions include exercise-induced anaphylaxis (EIA) and cholinergic urticaria (ChoIU). Read More

Ann Allergy Asthma Immunol 2020 Jun 30. Epub 2020 Jun 30.

Division of Pathology& Microbiology, National Institute of Nutrition, Hyderabad, India.

Background: Food allergy (FA) is a chronic condition of emerging global concern. Surveys have been conducted in numerous countries to assess physician knowledge, attitude, and practices (KAP) pertaining to FA and anaphylaxis and substantial deficits in their KAP were identified.

Objective: The present study aims to assess the knowledge, attitude, and practices (KAP) of medical clinicians in Hyderabad, India with respect to FA and anaphylaxis. Read More

Acta Derm Venereol 2020 Jul 3. Epub 2020 Jul 3.

Department of Dermatology, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-7. Epub 2020 May 3.

Division of Cardiology, Department of Internal Medicine, Henry Ford Hospital, 2799 W. Grand Blvd, Detroit, MI 48202, USA.

Background: Gadolinium-based contrast agents have been used as an alternative to iodinated contrast agents for simple percutaneous coronary interventions (PCIs) in patients with obstructive coronary artery disease. Their use has been limited in complex PCI due to poor image quality with gadolinium contrast. Significant dilution of gadolinium is required in an effort to avoid malignant ventricular arrhythmias. Read More

J Dent Anesth Pain Med 2020 Jun 24;20(3):173-178. Epub 2020 Jun 24.

Department of Anesthesiology and Pain Medicine, Dankook University College of Medicine, Cheonan, Korea.

We experienced a case of induction of general anesthesia without using neuromuscular blocking agents (NMBAs) in a 40-year-old woman with a history of anaphylaxis immediately after the administration of anesthetics lidocaine, propofol, and rocuronium to perform endoscopic sinus surgery 2 years before. The skin test showed a positive reaction to rocuronium and cis-atracurium. We induced general anesthesia without using NMBAs after inducing airway anesthesia with lidocaine (transtracheal injection and superior laryngeal nerve block). Read More

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656720937694. Epub 2020 Jun 22.

Allergy Immunology Associates, Inc., Mayfield Heights, Ohio.

Introduction: Interleukin-1 (IL-1) antagonists have been successful in the management of monogenic auto-inflammatory diseases, notably classic hereditary fever syndromes, such as Familial Mediterranean Fever (FMF). Anakinra (Kineret®), a human recombinant IL-1 receptor antagonist (IL-1Ra), has been clinically effective in the management of persistent auto-inflammation, such as FMF. Few studies report anaphylaxis in response to anakinra, which were resolved with an anakinra desensitization or the anti-IL-1β monoclonal antibody canakinumab (ILARIS®). Read More

Pediatr Rev 2020 Jul;41(7):348-356

UT Health San Antonio, San Antonio, TX.

Insect stings can generate a range of immune and clinical reactions. Most reactions are local and self-limiting. Allergic reactions to insect stings can occur at all ages, with or without previous stings. Read More

Allergy Asthma Clin Immunol 2020 26;16:56. Epub 2020 Jun 26.

Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, McGill University, Montreal, QC Canada.

Background: While drug reactions to rituximab have been commonly reported in the literature, a type I allergic reaction to rituximab after first lifetime exposure has never been reported.

Case Presentation: We describe a case of a 58-year-old female patient who received rituximab for the first time for treatment of rheumatoid arthritis. She developed symptoms immediately after infusion, however presented 11 days after drug exposure with cyclical anaphylaxis-like reaction requiring multiple doses of epinephrine. Read More

Allergy Asthma Proc 2020 Jul;41(4):301-304

Division of Allergy and Immunology, Naval Medical Center Portsmouth, Portsmouth, Virginia.

Cold-induced urticaria can take place either due to direct cold exposure, cryoglobulinemia, or genetic component (such as cryopyrin-associated periodic syndrome), which leads to the rapid onset of urticaria and/or angioedema. It is more common in younger patients and more likely to affect females compared with males. To increase awareness of such systemic reactions of anaphylaxis and provide a focused review of the differential diagnosis, underlying mechanisms, broad workup, and management of this disease process for allergy/immunology fellows, residents, general physicians, and general practitioners. Read More

Allergy Asthma Proc 2020 Jul;41(4):290-295

From the Department of Internal Medicine, Division of Rheumatology, Allergy & Immunology, University of California San Diego, San Diego, CA.

The booklouse, Liposcelis bostrychophila, is a potent environmental allergen clinically associated with rhinoconjunctivitis and asthma. Despite its known infestation of grain products, anaphylaxis from ingestion of this organism has, to our knowledge, not been previously reported. We present the case of a 44-year-old woman who developed anaphylaxis to ingested oats and rice shown to be contaminated with L. Read More

J Allergy Clin Immunol Pract 2020 Jun 27. Epub 2020 Jun 27.

Massachusetts General Hospital for Children, Food Allergy Center. Department of Pediatrics, Massachusetts General Hospital, Boston, MA.

J Allergy Clin Immunol Pract 2020 Jun 27. Epub 2020 Jun 27.

Food Allergy Referral Centre, Veneto Region, Department of Woman and Child Health, Padua University Hospital, Padua Italy. Electronic address:

J Allergy Clin Immunol 2020 Jun 27. Epub 2020 Jun 27.

Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutritional Medicine, University of Lübeck and University Medical Center Schleswig Holstein, Lübeck, Germany; Airway Research Center North (ARCN), University of Lübeck, German Center for Lung Research (DZL), Lübeck, Germany. Electronic address:

Murine blood IgG1, but not IgG2a, sialylation levels attenuate IgG-mediated and IgG-controlled IgE-mediated allergic reactions by enhancing the expression of the IgG inhibitory Fcγ receptor IIB on immune cells, accordingly, human blood IgG sialylation levels correlate with FcγRIIB expression. Read More

Br J Anaesth 2020 Jun 26. Epub 2020 Jun 26.

Sydney, Australia. Electronic address:

Aorta (Stamford) 2020 Feb 29;8(1):21-22. Epub 2020 Jun 29.

Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India.

Hydatid disease is a parasitic infestation caused by the larval stage of . It can infest any part of the body; however, aortic hydatid disease is rare. Involvement of the abdominal aorta is usually due to embolization from cardiac hydatid cysts or direct invasion and can be present at intravascular or intramural locations. Read More

Biomed Res Int 2020 24;2020:7301652. Epub 2020 May 24.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Cholinergic urticaria (CholU) is a subset of chronic inducible urticaria characterized by the recurrent pinpoint-sized wheals that are induced by exercising or increasing core body temperature. Currently, the data of CholU in tropical climate is still limited.

Objective: To investigate the clinical features and natural course of CholU in a tropical country. Read More

SAGE Open Med Case Rep 2020 17;8:2050313X20933104. Epub 2020 Jun 17.

Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Myocardial injury or infarction in the setting of anaphylaxis can be due to anaphylaxis itself, known as Kounis syndrome, or as a result of treatment with epinephrine. Myocardial ischemia caused by therapeutic doses of epinephrine in the setting of anaphylaxis is a rare event attributed to coronary artery vasospasm. A 41-year-old female with past medical history of recurrent costochondritis, chronic thrombocytopenia, and nonspecific palindromic rheumatism presented to the emergency department with perioral numbness, flushing and throat tightness after a meal containing fish and almonds. Read More

Contact Dermatitis 2020 Jun 26. Epub 2020 Jun 26.

Laboratorios DIATER. Madrid., Spain.

Background: Occupational contact urticaria due to inhalation of legume pest allergens has rarely been described.

Objective: To determine the cause of an outbreak of airborne contact urticaria, asthma and anaphylaxis in farmers and agronomists studying the disinsectization of dried peas. Peas were treated with aluminum phosphide (EPA). Read More

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):401-406

San Antonio Asthma and Allergy Clinic, San Antonio, Texas, USA.

Purpose Of Review: The objective of this article is to review the available literature regarding the risks associated with sublingual immunotherapy and angiotensin-converting enzyme (ACE) inhibitors or β-blocker use. It also evaluates for any differences in these risks among the available sublingual immunotherapy (SLIT) tablets.

Recent Findings: A literature search was conducted in PubMed to identify peer-reviewed articles using the following keywords: anaphylaxis, ACE inhibitor, β-blocker, and sublingual immunotherapy. Read More

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):352-361

Department of Infectious Diseases, Centre for Antibiotic Allergy and Research, Austin Health.

Purpose Of Review: Glycopeptide antibiotics such as vancomycin are frequently utilized to treat resistant Gram-positive infections such as methicillin-resistant Staphylococcus aureus. The current literature on glycopeptide and lipoglycopeptide structure, hypersensitivity and potential cross-reactivity was reviewed, highlighting implications for safe prescribing.

Recent Findings: Structurally similar, glycopeptides could theoretically cross-react. Read More

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):346-351

Translational Immunology Unit, Immunology Area, Pediatric Hospital Bambino Gesù, IRCCS, Rome, Italy.

Purpose Of Review: This review summarizes the current knowledge of the pathogenic mechanisms of biologics-induced anaphylaxis, and the diagnostic and prophylactic strategies in the management of potentially reactive patients, to improve the safety profile of biologics.

Recent Findings: The recent knowledge on the topic highlights the involvement of both effector and regulatory mechanisms in the immune response to biological agents. In addition, the impact of biological's immunogenicity on hypersensitivity reactions has been confirmed in a wider number of studies, defining some details about the kinetics of antidrug antibodies development, specifically immunoglobulin G (IgG) and immunoglobulin E (IgE). Read More

Allergy 2020 Jun 26. Epub 2020 Jun 26.

Transylvania University Brasov, Brasov, Romania.

Clin Microbiol Infect 2020 Jun 22. Epub 2020 Jun 22.

Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé Environnement Travail), UMR_S 1085, 35000, Rennes, France.

J Allergy Clin Immunol 2020 Jun 22. Epub 2020 Jun 22.

Division of Allergy and Immunology, Department of Dermatology, Venerology, and Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany. Electronic address:

Background: Venom-induced anaphylaxis is a common, potentially life-threatening hypersensitivity reaction associated with specific: 1) symptom profile, 2) cofactors, and 3) management. Identifying the differences in phenotypes of anaphylaxis is crucial for future management guidelines and the development of a personalized medicine approach.

Objective: This study aimed to evaluate the phenotype and risk factors of venom-induced anaphylaxis. Read More

PLoS One 2020 25;15(6):e0235076. Epub 2020 Jun 25.

Departments of Medicine and Pharmacy, University of California, San Francisco, California, United States of America.

Due to the complexity and fragility of biological drug products, several challenges exist in their formulation development. Excipients are added to increase product stability, maintain tonicity, and facilitate drug delivery. The potential implications of these additive substances merit clinical consideration. Read More

Allergy 2020 Jun 25. Epub 2020 Jun 25.

Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

With the worldwide spread of the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) resulting in declaration of a pandemic by the World Health Organization (WHO) on March 11, 2020, the SARS-CoV-2-induced Coronavirus disease-19 (COVID-19) has become one of the main challenges of our times. The high infection rate and the severe disease course led to major safety and social restriction measures worldwide. There is an urgent need of unbiased expert knowledge guiding the development of efficient treatment and prevention strategies. Read More

Clin Mol Allergy 2020 23;18:11. Epub 2020 Jun 23.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Background: Sensitization to peanuts and hazelnuts is common among young asthmatics and can be primary or a result of cross-reactivity. Sensitization as a result of cross-reactivity to birch pollen is typically associated to tolerance or mild and local symptoms upon intake of peanut or hazelnut.

Aim: The aim of this study was to investigate relationships between IgE antibody responses against peanut and hazelnut components, airway and systemic inflammation markers, lung function parameters and reported food hypersensitivity in a cohort of asthmatic children and young adults. Read More

Allergy 2020 Jun 23. Epub 2020 Jun 23.

University Hospital of Montpellier, Montpellier, France.

The International Classification of Diseases (ICD) provides a common language for use worldwide as a diagnostic and classification tool for epidemiology, clinical purposes and health management. Since its first edition, the ICD has maintained a framework distributing conditions according to topography, with the result that some complex conditions, such as allergies and hypersensitivity disorders (A/H) including anaphylaxis, have been poorly represented. The change in hierarchy in ICD-11 permitted the construction of the pioneer section addressed to A/H, which may result in more accurate mortality and morbidity statistics, including more accurate accounting for mortality due to anaphylaxis, strengthen classification, terminology and definitions. Read More

HeartRhythm Case Rep 2020 Jun 26;6(6):322-324. Epub 2020 Feb 26.

Department of Cardiology, Duke University School of Medicine.

Allergy Asthma Clin Immunol 2020 19;16:51. Epub 2020 Jun 19.

Pediatric Allergy and Clinical Immunology, CHU Sainte-Justine, 3175 chemin de la Côte-Sainte-Catherine, Montreal, QC H3T 1C5 Canada.

Background: The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported.

Case Presentation: We describe the first case of intravenous clindamycin anaphylaxis, with likely sensitization due to previous topical exposure to clindamycin gel for acne in a 14-year-old boy with history of atopy and mild atopic dermatitis. Read More

Mucosal Immunol 2020 Jun 23. Epub 2020 Jun 23.

Mary H Weiser Food Allergy Center, Department of Pathology, Michigan Medicine, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.

Food-triggered anaphylaxis can encompass a variety of systemic and intestinal symptoms. Murine-based and clinical studies have revealed a role for histamine and H1R and H2R-pathway in the systemic response; however, the molecular processes that regulate the gastrointestinal (GI) response are not as well defined. In the present study, by utilizing an IgE-mast cell (MC)-dependent experimental model of oral antigen-induced anaphylaxis, we define the intestinal epithelial response during a food-induced anaphylactic reaction. Read More

Ann Allergy Asthma Immunol 2020 Jun 20. Epub 2020 Jun 20.

Fundación Ayre, Salta, Argentina. Electronic address:

J Investig Allergol Clin Immunol 2020 Jun 23. Epub 2020 Jun 23.

Head of Allergy service of Hospital Clínico Universitario Lozano Blesa, IIS-Aragón.

Expert Rev Clin Immunol 2020 Jul 8:1-11. Epub 2020 Jul 8.

Division of Allergy, Immunology and Rheumatology, University of North Carolina School of Medicine , Chapel Hill, NC, USA.

Introduction: Alpha-gal Syndrome (AGS) is a unique allergy to non-primate mammalian meat (and derived-products) that is associated with tick bites and is due to a specific IgE antibody to the oligosaccharide galactose-α-1,3-galactose (alpha-gal). AGS has many novel features that broaden the paradigm of food allergy, including that reactions are delayed 3-6 hours after exposure and patients have frequently tolerated red meat for many years prior to the development of allergic reactions. Due to the ubiquitous inclusion of mammal-derived materials in foods, medications, personal products and stabilizing compounds, full avoidance is difficult to achieve. Read More

Ann Allergy Asthma Immunol 2020 Jun 19. Epub 2020 Jun 19.

Inflammation, Repair and Development Section, National Heart & Lung Institute, Imperial College London, London, UK; Centre of Evidence-based Dermatology, University of Nottingham, Nottingham, UK. Electronic address:

Objective: Food allergy is a common condition which can have a significant impact on the quality of life of affected individuals and their caregivers. Recent years have witnessed an increased effort to identify new treatments for food allergy. Here we review the need to identify core outcomes for measurement in clinical trials of food allergy treatments. Read More

Am J Forensic Med Pathol 2020 Jun 18. Epub 2020 Jun 18.

Institute of Clinical Pathology, Medical College of Shantou University, Shantou, Guangdong Province, China.

Anaphylaxis is a serious reaction that may cause death in half an hour without diagnostic characteristic in autopsies. Mast cell (MC) degranulation combined with immunoglobulin E (IgE) plays the key roles in anaphylaxis. Unavailability of serum and instability of measured serum in postmortem diagnoses sometimes limit the opinion of medical experts. Read More

Allergol Select 2020 28;4:11-43. Epub 2020 May 28.

Department of Dermatology and Allergology am Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.

This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology, and the Paul-Ehrlich Society for Chemotherapy in a consensus procedure according to the criteria of the German Association of Scientific Medical Societies. BLA such as penicillins and cephalosporins represent the drug group that most frequently triggers drug allergies. However, the frequency of reports of suspected allergy in patient histories clearly exceeds the number of confirmed cases. Read More