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Actas Dermosifiliogr 2021 Jun 18. Epub 2021 Jun 18.

Servicio de Dermatología, Complejo Asistencial de Zamora, Zamora, Spain.

This article, part of a the series on safety in dermatologic procedures, covers the diagnosis, prevention, management, and treatment of 3 situations or conditions. The first condition we address is anaphylaxis, an uncommon but severe and potentially fatal reaction that must be recognized quickly so that urgent management coordinated with an anesthesiologist can commence. The second is fainting due to a vasovagal reaction, which is the most common complication in dermatologic surgery. Read More

J Allergy Clin Immunol Pract 2021 Jun 18. Epub 2021 Jun 18.

Department of Paediatrics, Royal College of Surgeons, Dublin, Ireland.

Concerns for anaphylaxis may hamper SARS-CoV-2 immunization efforts. We convened a multi-disciplinary group of international experts in anaphylaxis comprised of allergy, infectious disease, emergency medicine, and front-line clinicians to systematically develop recommendations regarding SARS-CoV-2 vaccine immediate allergic reactions. Medline, EMBASE, Web of Science, the WHO global coronavirus database, and the grey literature (inception-March 19, 2021) were systematically searched. Read More

Pediatr Allergy Immunol 2021 Jun 21. Epub 2021 Jun 21.

Children's Health Ireland, Dublin, Ireland.

Background: Internationally, the COVID-19 pandemic severely curtailed access to hospital facilities for those awaiting elective/semi elective procedures. For allergic children in Ireland, already waiting up to 4 years for an elective oral food challenge (OFC), the restrictions signified indefinite delay. At the time of the initiative there were approx 900 children on the Children's Health Ireland (CHI) waiting list. Read More

Anesth Pain Med 2020 Oct 31;10(5):e104796. Epub 2020 Aug 31.

Student Research Committee, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: Meperidine is known as the gold standard drug for shivering after spinal anesthesia (SA). This drug has been used widely and safely during the Cesarean Section (CS).

Case Presentation: This case report presents an anaphylaxis reaction to a single intravenous dose of 25 mg meperidine, aiming to control shivering during CS under SA a few minutes after surgical incision. Read More

Curr Treat Options Allergy 2021 Jun 15:1-14. Epub 2021 Jun 15.

Section of Allergy, Immunology and Retrovirology, Baylor College of Medicine, Houston, TX USA.

Purpose Of Review: In this review, we sought to describe the most recent advances in the dietary and medical management of peanut and tree nut allergy, including selective introduction and immunotherapy.

Recent Findings: Dietary updates include changes to labeling laws, improved information sources, and new apps for buying foods in shops and overseas to better protect individuals with nut allergies. There are still issues in the management of nut allergies in schools, such as parents having to resort to packed lunches instead of school meals and patients experiencing bullying. Read More

Am J Transl Res 2021 15;13(5):4978-4986. Epub 2021 May 15.

Nursing Department, Yichun People's Hospital Yichun 336000, Jiangxi Province, China.

Objective: This study aimed to explore the effect of predictive nursing on the comfort, illness perception, metabolism of calcium and phosphorus, and complication of hemodialysis patients.

Methods: A total of 160 patients admitted to our hospital were selected as the research participants. Among them, 80 patients who did not undergo predictive nursing before admission were divided into the control group, and 80 patients who received predictive nursing before admission were divided into the study group. Read More

J Emerg Med 2021 Jun 17. Epub 2021 Jun 17.

Department of Pediatrics, Soroka University Medical Center, Beer Sheva, Israel; Pediatric Pulmonary Unit, Soroka University Medical Center, Beer Sheva, Israel; Faculty of Health Sciences, Ben-Gurion, University of the Negev, Beer Sheva, Israel.

Background: Spontaneous pneumomediastinum (SPM) occurs in cases of mediastinal leaks that are not caused by trauma, mechanical ventilation, or other surgical procedures. In most cases, in the pediatric population a trigger can be identified, most commonly asthma. SPM caused by foreign body aspiration is not a common entity. Read More

J Allergy Clin Immunol Pract 2021 Jun 17. Epub 2021 Jun 17.

Dartmouth-Hitchcok Medical Center, Section of Allergy and Immunology, Lebanon, NH; Geisel School of Medicine at Dartmouth, Hanover, NH. Electronic address:

Overdiagnosis of anaphylaxis-risk is an underappreciated aspect of anaphylaxis prevention. While the benefits of anaphylaxis-risk prevention are well-known, potential harms resulting from pre-emptive approaches to mitigate anaphylaxis-risk are not insignificant. Still, great progress has been made in recent years to avoid the unintended consequences of anaphylaxis-risk overdiagnosis. Read More

Clin Exp Allergy 2021 Jun 17. Epub 2021 Jun 17.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.

Background: 2-4% Of infants are affected by cow's milk allergy (CMA), which persists in 20% of cases. Intervention approaches using early oral exposure to cow's milk protein or hydrolyzed cow's milk formula are being studied for CMA prevention. Yet, concerns regarding safety and/or efficacy remain to be tackled in particular for high-risk non-exclusively breastfed infants. Read More

Clin Exp Allergy 2021 Jun 18. Epub 2021 Jun 18.

School of Psychology, Faculty of Health & Medical Sciences, University of Surrey, Guildford, United Kingdom.

Food allergy (FA) is a source of anxiety which affects the quality of life (QoL) of individuals and their caregivers (1). Furthermore, parental anxiety is a risk factor for anxiety development in children with offspring of anxious parents being seven times more likely to meet the criteria for an anxiety disorder (2). Recommendations have been made to address parental anxiety and its associated restrictive behaviours specifically for children with FA (3). Read More

Clin Exp Allergy 2021 Jun 18. Epub 2021 Jun 18.

Laboratory of Medical Allergology, Copenhagen University Hospital at Gentofte, Denmark.

Anaphylaxis is the most severe manifestation of allergy, often with rapid, unexpected onset, leading to development of life-threatening symptoms from airway and/or circulation. Despite many years of research, the specific mechanisms involved and biomarkers for detecting anaphylaxis are still elusive . Read More

Fa Yi Xue Za Zhi 2021 Apr;37(2):211-214

School of Forensic Medicine, Shanxi Medical University, Jinzhong 030600, Shanxi Province, China.

Abstract: Objective To study the DNA methylation of nucleated cells in peripheral blood of patients died from anaphylactic shock caused by cephalosporin drugs and to provide a new research direction and basis for the forensic diagnosis of shock caused by drug hypersensitiveness. Methods Methylation microarray was used to detect DNA methylation of nucleated cells in peripheral blood of patients died from anaphylactic shock caused by cephalosporin drugs and normal subjects. Sequencing data and chip data were analyzed for differences in DNA methylation using R language methylkit, ChAMP package. Read More

Pediatr Allergy Immunol 2021 Jun 17. Epub 2021 Jun 17.

University Hospital of Montpellier, Montpellier, France.

Background: Anaphylaxis is a recognized public health issue. There is no doubt that food-induced anaphylaxis (FIA) has tremendous impact on the quality of life of patients and their families and increases direct and indirect costs. FIA is associated with increasing rates of emergency department admissions and hospitalizations and implies the risk of death. Read More

World J Emerg Med 2021 ;12(3):238-240

Department of Emergency Medicine, the First Affiliated Hospital, China Medical University, Shenyang 110001, China.

Allergol Int 2021 Jun 14. Epub 2021 Jun 14.

Aichi Children's Health and Medical Center, Aichi, Japan.

Background: Since few studies have analyzed time trends in pediatric anaphylaxis, including triggers and adrenaline usage, this study aimed to reveal these issues in a comprehensive analysis of pediatric anaphylaxis cases.

Methods: The Aichi Medical Association performed a comprehensive survey of pediatric anaphylaxis cases aged under 15 years from 87 secondary and 25 tertiary emergency care hospitals in Aichi Prefecture (population 7.5 million), Japan. Read More

J Dent Anesth Pain Med 2021 Jun 1;21(3):227-236. Epub 2021 Jun 1.

Duke University Nurse Anesthesia Program, Durham, NC, USA.

Background: Emergencies in outpatient clinics are rare. However, potentially catastrophic events can be challenging to manage due to a variety of factors, including limited equipment and staff. The purpose of this quality improvement project was to improve the staff knowledge and familiarity with critical performance elements for emergencies encountered in the setting of a periodontics clinic. Read More

Immunotargets Ther 2021 9;10:171-184. Epub 2021 Jun 9.

McMaster Immunology Research Centre, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. IgG memory B cells replenish pools of IgE-secreting cells upon allergen exposure, which contract thereafter due to the short lifespan of tightly regulated IgE-expressing cells. Advances in the detection and highly dimensional analysis of allergen-specific B and T cells from allergic patients have provided insight on their phenotype and function. Read More

Clin Transl Allergy 2021 Jun 9;11(4):e12014. Epub 2021 Jun 9.

Latvain Association of Allergists University Children Hospital Riga Latvia.

Front Immunol 2021 31;12:663726. Epub 2021 May 31.

Department of Biochemistry, Kangwon National University, Chuncheon, South Korea.

In a previous study, we have demonstrated that p62, a selective receptor of autophagy, can regulate allergic inflammation. In the present study, microRNA array analysis showed that miR-154-5p was increased by antigen (DNP-HSA) in a p62-dependent manner in rat basophilic leukemia cells (RBL2H3). NF-kB directly increased the expression of miR-154-5p. Read More

Arerugi 2021 ;70(4):293-301

Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital.

Background: To clarify the status of admission to facilities for food allergy (FA) children.

Methods: Guardians of FA children who underwent oral food challenges at Sagamihara National Hospital from September to December 2018 were enrolled. We surveyed the experience of refusal to enter facilities, the reason for refusal and so on using a self-administered questionnaire. Read More

Leg Med (Tokyo) 2021 Jun 9;53:101930. Epub 2021 Jun 9.

Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China. Electronic address:

The aim of this study was to detect the postmortem serum total IgE levels in frozen corpses and identify whether the death incident caused by an anaphylaxis in forensic medicine. Autopsy cases with pathological death (total, n = 106; 4-214 h postmortem) include cardiac disease (n = 15), pulmonary infection (n = 12), central nervous system disorder (n = 6), pulmonary emboliszn (n = 7), hapetic disease (n = 5), kidney disease (n = 6), enteric disease (n = 10), necrotizing pancreatitis (n = 7), diffuse peritonitis (n = 6), MODS (n = 6), toxicosis (n = 5:), anaphylactic shock (n = 7), bronchial asthma (n = 8) and other disease (n = 6) were examined. Results showed that there was no significant difference between serum IgE levels and ages, postmortem intervals (PMIs), gender as well as survival time. Read More

Allergy 2021 06;76(6):1934-1937

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Allergy 2021 06;76(6):1938-1940

Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.

Allergy 2021 Jun;76(6):1932-1933

Department of Internal Medicine and Allergology, University Medical Center Groningen, Groningen, The Netherlands.

J Travel Med 2021 Jun 14. Epub 2021 Jun 14.

Navitas Clinic Kawasaki, Kanagawa, Japan.

Notf Rett Med 2021 Jun 10:1-77. Epub 2021 Jun 10.

Southmead Hospital, North Bristol NHS Trust, Bristol, Großbritannien.

These guidelines of the European Resuscitation Council (ERC) Cardiac Arrest under Special Circumstances are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. This section provides guidelines on the modifications required for basic and advanced life support for the prevention and treatment of cardiac arrest under special circumstances; in particular, specific causes (hypoxia, trauma, anaphylaxis, sepsis, hypo-/hyperkalaemia and other electrolyte disorders, hypothermia, avalanche, hyperthermia and malignant hyperthermia, pulmonary embolism, coronary thrombosis, cardiac tamponade, tension pneumothorax, toxic agents), specific settings (operating room, cardiac surgery, cardiac catheterization laboratory, dialysis unit, dental clinics, transportation [in-flight, cruise ships], sport, drowning, mass casualty incidents), and specific patient groups (asthma and chronic obstructive pulmonary disease, neurological disease, morbid obesity, pregnancy). Read More

J Allergy Clin Immunol Pract 2021 Jun 11. Epub 2021 Jun 11.

Division of Allergy and Immunology, Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL 33612.

J Allergy Clin Immunol 2021 Jun 11. Epub 2021 Jun 11.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA. Electronic address:

Background: Blocking the major cat allergen, Fel d 1, with monoclonal antibodies (mAbs) was effective in preventing an acute cat-allergic response.

Objective: We sought to extend the allergen-specific antibody approach and demonstrate that a combination of mAbs targeting Bet v 1, the immunodominant and most abundant allergenic protein in birch pollen, can prevent the birch-allergic response.

Methods: Bet v 1-specific mAbs, REGN5713, REGN5714 and REGN5715, were isolated using the VelocImmune platform. Read More

Eur Ann Allergy Clin Immunol 2021 Jun 11. Epub 2021 Jun 11.

Division of Clinical Immunology and Allergy, Department of Medicine, University Hospital and Faculty of Medicine, Geneva, Switzerland.

Clin Transl Allergy 2021 Jun 3;11(4):e12038. Epub 2021 Jun 3.

Department of Pharmacy Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.

Background: Monoclonal antibodies (mAbs) are novel, effective therapeutics for the treatment of inadequately controlled severe asthma. Knowledge of the anaphylaxis risks related to different mAbs is essential for their appropriate and safe administration. This study aimed to evaluate the associations between different mAbs and anaphylactic reactions by applying statistical approaches to pharmacovigilance data. Read More