254,970 results match your criteria Analytical methods : advancing methods and applications[Journal]


Dual-Surfactant-Capped Ag Nanoparticles as a Highly Selective and Sensitive Colorimetric Sensor for Citrate Detection.

ACS Omega 2020 May 7;5(19):10696-10703. Epub 2020 May 7.

School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.

A colorimetric sensor for the detection of citrate ions is reported here using dual-surfactant-capped Ag nanoparticles (dual-AgNP sensor). A mixture of cetyl trimethyl ammonium bromide and a newly prepared gemini nonionic (GFEO) surfactant was used as a capping agent to synthesize dual-surfactant-capped Ag NPs for selective and sensitive citrate detection. The GFEO surfactant was designed with a specific chemical structure to provide strong binding with citrate for selective and sensitive detection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.9b04199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240824PMC

Molecular Model Construction and Evaluation of Jincheng Anthracite.

ACS Omega 2020 May 8;5(19):10663-10670. Epub 2020 May 8.

College of Mining Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China.

Despite its importance, limited representations of the anthracite models have been developed. The first molecular representation of Chinese Jincheng anthracite with the incorporation of diverse molecular structures was constructed based on the available analytical data. Three hundred individual aromatic sheets were first built based on the aromatic fringe distribution obtained from high-resolution transmission electron microscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.9b03894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240822PMC

Surveying sleep quality and fatigue in multiple sclerosis patients at a multiple sclerosis center in Kermanshah, Iran, in 2017.

Neurobiol Sleep Circadian Rhythms 2020 May 11;8:100050. Epub 2020 May 11.

Nursing Department, Nursing and Midwifery School, Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Multiple sclerosis (MS) is an autoimmune disease of the nervous system which appears with de-myelination of the central nervous system. Sleep disorder and fatigue are very common in MS patients and are part of the main debilitating factors in patients. The present study was conducted to survey sleep quality and fatigue in MS patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbscr.2020.100050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236050PMC

Antioxidant Potential Overviews of Secondary Metabolites (Polyphenols) in Fruits.

Int J Food Sci 2020 7;2020:9081686. Epub 2020 May 7.

College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.

The rise in consumption of energy-dense foods has resulted in the displacement of several essential dietary gaps, causing numerous long-lasting diseases, including obesity, stroke, hypertension, and several forms of cancer. Epidemiological studies encourage more fruit consumption to prevent these diseases. The defensive mechanisms provided by these fruits against illness are due to the existence of several antioxidants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/9081686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229537PMC

Improvement in the Analytical Capabilities of LA-ICP-MS for High Spatial Resolution U-Pb Dating of Zircon Using Mixed-Gas Plasma.

J Anal Methods Chem 2020 11;2020:1819639. Epub 2020 May 11.

Key Laboratory of Groundwater Science and Engineering, Ministry of Natural Resources, Institute of Hydrology and Environmental Geology, CAGS, Shijiazhuang 050061, China.

In this work, a novel method for high spatial resolution U-Pb dating of zircon by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) at 10-16 m spot diameter has been proposed. This was achieved by introducing 2% (/) water-ethanol vapours into ICP in combination with the shielded torch system to increase the sensitivity and suppress the isotopic fractionation effect. Precise and accurate concordant U-Pb ages for Plešovice, GJ-1, and 91500 zircons were obtained using the proposed method, and the results agreed well with the isotope dilution-thermal ionization mass spectrometry (ID-TIMS) and LA-ICP-MS within 2, except for the ages obtained using dry plasma at 10 m spot diameter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/1819639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238343PMC

A High Performance Thin Layer Chromatographic Method Using a Design of Experiment Approach for Estimation of Phytochemicals in Extracts of Leaves.

Turk J Pharm Sci 2020 Apr 24;17(2):148-158. Epub 2020 Apr 24.

Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Clinic of Pharmaceutical Chemistry, Maharashtra, India.

Objectives: A systematic design of experiment (DoE) based sensitive, robust high performance thin layer chromatographic (HPTLC) method was established for simultaneous estimation of gallic acid (GA), quercetin (QT), and rutin (RT) from ethanolic and aqueous leaf extracts of .

Materials And Methods: The chromatographic separation was carried on Merck TLC aluminum sheets of silica gel 60 F254 (10×10 cm) with mobile phase of toluene: ethyl acetate: methanol: formic acid (4.9:4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4274/tjps.galenos.2018.80958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227920PMC

Investigation of the Presence of Sildenafil in Herbal Dietary Supplements by Validated HPLC Method.

Authors:
Emrah Dural

Turk J Pharm Sci 2020 Feb 19;17(1):56-62. Epub 2020 Feb 19.

Sivas Cumhuriyet University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Sivas, Turkey.

Objectives: As the first FDA-approved phosphodiesterase type 5 inhibitor, sildenafil (SDF) is widely used in the treatment of erectile dysfunction due to its strong pharmacodynamic activity. Since many food supplements are now involved in illegal adulteration, the presence of SDF in food supplements is very important because of their toxicological risks. In this study a simple fast, reliable high-performance liquid chromatography method with ultraviolet (UV) detector has been developed and validated for SDF analysis in herbal dietary supplements (HDSs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4274/tjps.galenos.2018.91249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227870PMC
February 2020

Nanocarriers Used Most in Drug Delivery and Drug Release: Nanohydrogel, Chitosan, Graphene, and Solid Lipid.

Turk J Pharm Sci 2019 Dec 11;16(4):481-492. Epub 2019 Nov 11.

University of Health Sciences, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey.

Over the past few years, nanocarriers have become an ideal solution for safe and efficient drug delivery and release. This is mainly due to the extraordinary characteristics that nanomaterials exhibit when compared with their larger scaled forms. A variety of these carriers are more popular due to their high biocompatibility, ensuring greater efficacy especially in cancer treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4274/tjps.galenos.2019.48751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227887PMC
December 2019

Investigation of the Voltammetric Behavior of Methyldopa at a Poly (-Aminobenzene Sulfonic Acid) Modified Sensor.

Turk J Pharm Sci 2019 Dec 11;16(4):450-456. Epub 2019 Nov 11.

İnönü University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Analytical Chemistry, Malatya, Turkey.

Objectives: The aim was to modify carbon electrodes with (p-aminobenzene sulfonic acid) and use them as a sensor for sensitive and reliable detection of methyldopa (MD) and ascorbic acid.

Materials And Methods: Electropolymerization was performed by cyclic voltammetry in 0.1 M KCl solution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4274/tjps.galenos.2018.44711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227888PMC
December 2019

Electroanalytical Determination of the Antiinflammatory Drug Tenoxicam in Pharmaceutical Dosage Forms.

Turk J Pharm Sci 2019 Jun 27;16(2):184-190. Epub 2019 Mar 27.

Karadeniz Technical University, Faculty of Pharmacy, Department of Analytical Chemistry, Trabzon, Turkey.

Objectives: The electro-oxidation behavior of the non-steroidal anti-inflammatory drug tenoxicam (TX) was studied on multiwalled carbon nanotube (MWCNT)-modified glassy carbon electrode (GCE) by cyclic voltammetry, differential pulse voltammetry (DPV), and square wave voltammetry (SWV).

Materials And Methods: The GCE was modified with MWCNT for sensitive determination of TX by voltammetric methods.

Results: The current peaks for TX occurred at around 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4274/tjps.galenos.2018.60783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227964PMC

Theory of an electron asymmetric scattering on skyrmion textures in two-dimensional systems.

J Phys Condens Matter 2020 May 26. Epub 2020 May 26.

Centre of Nanoheterostructure Physics, Ioffe Institute, 26 Politekhnicheskaya, Sankt-Peterburg, 194021, RUSSIAN FEDERATION.

We discuss in detail the electron scattering pattern on skyrmion-like magnetic textures in twodimensional geometry. The special attention is focused on analyzing the scattering asymmetry, which is a precursor of the topological Hall eect. We present analytical results valid in the limiting regimes of strong and weak coupling, we analyze analytically the conditions when the transverse response acquires a quantized character determined by the topological charge of a magnetic texture, we also derive the numerical scheme that gives access to the exact solution of the scattering problem. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-648X/ab966eDOI Listing

Body torsional flexibility effects on stability during trotting and pacing based on a simple analytical model.

Bioinspir Biomim 2020 May 26. Epub 2020 May 26.

Kyoto University Faculty of Engineering Graduate School of Engineering, Kyoto, JAPAN.

Quadruped animals use not only their legs but also their trunks during walking and running. Although many previous studies have investigated the flexion, extension, and lateral bending of the trunk, few studies have investigated the body torsion, and its dynamic effects on locomotion thus remain unclear. In this study, we investigated the effects of body torsion on gait stability during trotting and pacing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1748-3190/ab968dDOI Listing

Interaction between particles and bubbles driven by ultrasound: Acoustic radiation force on an elastic particle immersed in the ideal fluid near a bubble.

Ultrason Sonochem 2020 May 18;67:105166. Epub 2020 May 18.

School of Physics and Information Technology, Shaanxi Normal University, Shaanxi Key Laboratory of Ultrasonics, Xi'an 710119, China.

A theoretical model is proposed to investigate the acoustic radiation force on the elastic particle for coupled particle-bubble system. Based on the sound scattering theory, an analytical expression of the force function is obtained for the particle in plane wave sound field. Numerical simulations are presented for elastic particle of stainless steel, steel or brass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ultsonch.2020.105166DOI Listing

Validation of SARS-CoV-2 detection across multiple specimen types.

J Clin Virol 2020 May 13;128:104438. Epub 2020 May 13.

Department of Laboratory Medicine, Virology Division, University of Washington, Seattle, WA, United States; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States. Electronic address:

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused considerable disruption across the world, resulting in more than 235,000 deaths since December 2019. SARS-CoV-2 has a wide tropism and detection of the virus has been described in multiple specimen types, including various respiratory secretions, cerebrospinal fluid, and stool.

Objective: To evaluate the accuracy and sensitivity of a laboratory modified CDCbased SARS-CoV-2 N1 and N2 assay across a range of sample types. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcv.2020.104438DOI Listing

Real-time PCR-based SARS-CoV-2 detection in Canadian laboratories.

J Clin Virol 2020 May 13;128:104433. Epub 2020 May 13.

National Microbiology Laboratory (NML), Public Health Agency of Canada (PHAC), Winnipeg, Manitoba, Canada.

With emergence of pandemic COVID-19, rapid and accurate diagnostic testing is essential. This study compared laboratory-developed tests (LDTs) used for the detection of SARS-CoV-2 in Canadian hospital and public health laboratories, and some commercially available real-time RT-PCR assays. Overall, analytical sensitivities were equivalent between LDTs and most commercially available methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcv.2020.104433DOI Listing

Evaluation of the COVID19 ID NOW EUA assay.

J Clin Virol 2020 May 15;128:104429. Epub 2020 May 15.

Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, United States.

Background: The SARS-CoV-2 pandemic caused a major surge in needed diagnostic capacity. In response, many EUA assays have become available for clinical laboratories, and more recently, the point of care device, Abbott ID NOW.

Objectives: To determine the analytical performance of the ID NOW assay for detecting SARS-CoV-2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcv.2020.104429DOI Listing

Viral gastroenteritis in hospitalized patients: Evaluation of immunochromatographic methods for rapid detection in stool samples.

J Clin Virol 2020 May 15;128:104420. Epub 2020 May 15.

Enterovirus and Viral Gastroenteritis Unit, National Centre for Microbiology (CNM), Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo km 2, Madrid, Spain. Electronic address:

Background: . Viral infections are recognized as the most common cause of acute gastroenteritis (AGE). Virus detection by immune analytical methods is recommended for diagnosis because of its simplicity and low cost. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcv.2020.104420DOI Listing

Rare thyroid malignancies in Europe: Data from the information network on rare cancers in Europe (RARECAREnet).

Oral Oncol 2020 May 23;108:104766. Epub 2020 May 23.

Evaluative Epidemiology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

Objective: Limited information is available on the incidence of rare thyroid cancer (TC) subtypes: anaplastic (ATC) and medullary (MTC). The aim of this study was to describe incidence variations and trends across European countries of all TC subtypes.

Materials And Methods: We used the RARECAREnet database including 80721 TC incident cases in the period 2000-2007 from 77 population-based cancer registries (CRs) in Europe. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2020.104766DOI Listing

Strategy for identification of new psychoactive substances in illicit samples using attenuated total reflectance infrared spectroscopy.

Forensic Sci Int 2020 Apr 25;312:110262. Epub 2020 Apr 25.

National Medicines Institute, 30/34 Chelmska Str., 00-725 Warsaw, Poland. Electronic address:

New strategy has been developed for the identification of novel psychoactive substances (NPS) in illicit samples. The methodology was based on the use of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-IR). First pass screening by ATR-IR allows known substances to be rapidly identified, while any non-matching samples are qualified by complementary analytical techniques and then feed back into the spectral libraries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.forsciint.2020.110262DOI Listing

Generalized Guerra's interpolation schemes for dense associative neural networks.

Neural Netw 2020 May 20;128:254-267. Epub 2020 May 20.

Dipartimento di Matematica e Fisica Ennio De Giorgi, Università del Salento, Italy; I.N.F.N., Sezione di Lecce, Italy.

In this work we develop analytical techniques to investigate a broad class of associative neural networks set in the high-storage regime. These techniques translate the original statistical-mechanical problem into an analytical-mechanical one which implies solving a set of partial differential equations, rather than tackling the canonical probabilistic route. We test the method on the classical Hopfield model - where the cost function includes only two-body interactions (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neunet.2020.05.009DOI Listing

Electrophilic chlorination of dibenzo-p-dioxin and dibenzofuran over composite copper and iron chlorides and oxides in combustion flue gas.

Chemosphere 2020 May 12;256:127065. Epub 2020 May 12.

CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China.

Dibenzo-p-dioxin (DD) and dibenzofuran (DF) chlorination mediated by Cu and Fe chlorides can make a direct contribution to the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in combustion flue gas. In this study, a kind of composite Cu and Fe chlorides and oxides (CuFeOCl) was prepared by impregnating oxides with HCl solution to imitate the coexistence status of Cu and Fe species in combustion flue gas. Composite CuFeOCl was active in promoting the electrophilic chlorination of DD/DF at 150-300 °C, with the highest activity at 200 °C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.127065DOI Listing

Usability and application of a data integration technique (following the thread) for multi- and mixed methods research: A systematic review.

Authors:
C M Dupin G Borglin

Int J Nurs Stud 2020 Apr 29;108:103608. Epub 2020 Apr 29.

Department of Nursing Education, Lovisenberg Diaconal University College, 0456 Oslo, Norway.

Background: The scope of methodological development and innovation in multi- and mixed methods design is endless and, at times, challenging. The latter is especially true with regards to the integration of data generated through different methods. About a decade ago, Professor Jo Moran-Ellis and her colleagues at the University of Sussex suggested a framework for analytical integration known as "following a thread. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijnurstu.2020.103608DOI Listing

Viscosity of API/fatty acid suspensions: pitfalls during analysis.

Int J Pharm 2020 May 23:119447. Epub 2020 May 23.

Laboratory of Pharmaceutical Technology, Ghent University, 9000 Ghent, Belgium. Electronic address:

This article describes how to obtain reliable data during rheological analysis of active pharmaceutical ingredient/fatty acid suspensions. These materials are specifically used for prilling, an innovative pharmaceutical technique for the production of a multiparticulate dosage form. Nevertheless, presented guidelines are applicable for a wide range of pharmaceutical suspensions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2020.119447DOI Listing

In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet granulation and its use in process development.

Int J Pharm 2020 May 23:119451. Epub 2020 May 23.

Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Ottergemsesteenweg 460, Ghent, Belgium. Electronic address:

Wetting is the initial stage of wet granulation processes during which the first contact between the powder and the liquid occurs. Wetting is a critical step to allow granule growth and consolidation, but also to ensure uniform active pharmaceutical ingredient (API) distribution over all granule size fractions. A physical understanding of the wetting stage is therefore crucial to design a robust granulation process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2020.119451DOI Listing

How well do laboratories adhere to recommended guidelines for dyslipidaemia management in Europe? The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) Study.

Clin Chim Acta 2020 May 23. Epub 2020 May 23.

Department of Clinical Chemistry, HUSLAB, Helsinki University Hospital, Helsinki, Finland.

Background: The CArdiac MARker Guidelines Uptake in Europe Study (CAMARGUE) initiated by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) aims to survey the current use of evidence-based guidelines for dyslipidemia testing in Europe.

Methods: In 2019 a web-based questionnaire was distributed via EFLM National Societies to clinical laboratories in Europe. Questions covered pre-analytics, analytical methods, measurement units, flagging of decision thresholds, and use of decision-enhancing comments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2020.05.038DOI Listing

Systematic evaluation and optimization of HPLC separation of polyoxins.

J Sep Sci 2020 May 26. Epub 2020 May 26.

Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, P.R. China.

Chromatographic behavior of a kind of nucleoside peptides, polyoxins, was investigated in this study. Molecular simulation technique was used to elucidate the temperature-dependent peak-sharpening of polyoxins. There was a relatively small energy barrier between the global minimum conformer and the local minimum conformer of polyoxin A and the high temperature helped to quickly cross the energy barrier and accelerate the conformational transformation for getting the global minimum, so that stationary phase could not identify these two conformations and presented a sharp peak. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.202000269DOI Listing

Cationic Oligomer as an Organic Template for Direct Synthesis of Aluminosilicate ITH Zeolite.

Angew Chem Int Ed Engl 2020 May 26. Epub 2020 May 26.

Universitat Politechnica de Valencia, Instituto de Techologia Quimica, SPAIN.

Despite great progress in the synthesis of aluminosilicate zeolites, there are still a large number of zeolites that could not be prepared in the aluminosilicate form. One of typical examples is ITH zeolite, where direct synthesis of aluminosilicate ITH is currently still challenging. Herein, for the first time we demonstrate the successful synthesis of aluminosilicate ITH zeolite using a simple cationic oligomer as an organic template. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202003282DOI Listing

[Simplified laboratory analysis of ethylene glycol allows improved management of poisoning cases].

Lakartidningen 2020 May 25;117. Epub 2020 May 25.

.

Toxicological analysis constitutes an important part of the acute treatment of poisonings. Timely laboratory results are essential for the patient to be diagnosed and treated appropriately, but also to exclude poisoning and avoid unnecessary overtreatment. Ingestion of ethylene glycol may cause acute kidney injury and, in severe cases, death, unless treated early with an antidote (ethanol infusion or fomepizole) to inhibit the formation of toxic metabolites. Read More

View Article

Download full-text PDF

Source

Perceived oral health interventions by medical providers in Gugulethu, South Africa.

PLoS One 2020 26;15(5):e0233437. Epub 2020 May 26.

Center for Global Health, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

Introduction: The purpose of this study was to explore factors that impact patients' ability to access high quality, expeditious oral health care by understanding medical professionals' knowledge of oral health, the care they provide to patients presenting with oral health complaints, and their perceptions of potential interventions to improve oral health care delivery.

Methods: We conducted in depth qualitative interviews, which were analyzed using an inductive content analytical approach. The study was conducted in Gugulethu, a community located outside of Cape Town, South Africa. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233437PLOS

The first IAEA inter-laboratory comparison exercise in Latin America and the Caribbean for stable isotope analyses of water samples.

Isotopes Environ Health Stud 2020 May 26:1-11. Epub 2020 May 26.

Isotope Hydrology Section/Laboratory, International Atomic Energy Agency, Vienna, Austria.

The use of stable isotopes (H and O) is widespread in water resources studies. In the Latin America and the Caribbean (LAC) region, the application of isotope techniques has increased in the past decade, but there remains room to gain self-reliance in environmental isotope studies, necessitating easy and fast access to good-quality isotope data. To that end, in 2018 the IAEA carried out the first regional interlaboratory comparison exercise, testing the analytical performance of 25 laboratories using isotope-ratio mass spectrometry and laser absorption spectroscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10256016.2020.1763338DOI Listing

DIRECT DIELECTRIC BARRIER DISCHARGE IONIZATION PROMOTES RAPID AND SIMPLE LUBRICANT OIL FINGERPRINTING.

J Am Soc Mass Spectrom 2020 May 26. Epub 2020 May 26.

Petroleomics, which is the characterization, separation and quantification of the components of petroleum and crude oil, is an emerging area of study. However, the repertoire of analytical methods available to understand commercial automotive lubricant oils (ALOs) is very limited. Ambient mass spectrometry is one of the most sensitive analytical methods for real-time and in situ chemical analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jasms.0c00071DOI Listing

Middle level IM-MS and CIU experiments for improved therapeutic immunoglobulin subclass fingerprinting.

Anal Chem 2020 May 26. Epub 2020 May 26.

Most of the current FDA and EMA approved therapeutic monoclonal antibodies (mAbs) are based on humanized or human IgG1, 2 or 4 subclasses and engineered variants. On the structural side, these subclasses are characterized by specific inter-chains disulfide bridge connections. Different analytical techniques have been reported to assess intact IgGs subclasses, with recently special interest in native ion mobility (IM) and collision induced unfolding (CIU) mass spectrometry (MS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.0c00293DOI Listing

Postmortem Analysis of Benzodiazepines in Human Bone by Gas Chromatography-Mass Spectrometry.

J Anal Toxicol 2020 May 26. Epub 2020 May 26.

Istituto Superiore di Sanità, Analytical Pharmacotoxicology, Viale Regina Elena, 299, 00161 Roma, Italy.

A procedure based on gas chromatography-mass spectrometry was developed for the analysis of benzodiazepines (nordiazepam, oxazepam, lormetazepam, lorazepam, clonazepam, bromazepam and alprazolam) in postmortem human ribs. Powdered bone samples, including marrow remains inside, with the internal standard diazepam-d5 were subjected to enzymatic hydrolysis with 100 μL of β-glucoronidase and were incubated in sodium hydroxide for 1 h in a 70°C oven. Samples underwent liquid phase extraction and ethyl acetate was used as eluent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jat/bkaa020DOI Listing

Monolysocardiolipin (MLCL) interactions with mitochondrial membrane proteins.

Authors:
Anna L Duncan

Biochem Soc Trans 2020 May 26. Epub 2020 May 26.

Department of Biochemistry, University of Oxford, Oxford, U.K.

Monolysocardiolipin (MLCL) is a three-tailed variant of cardiolipin (CL), the signature lipid of mitochondria. MLCL is not normally found in healthy tissue but accumulates in mitochondria of people with Barth syndrome (BTHS), with an overall increase in the MLCL:CL ratio. The reason for MLCL accumulation remains to be fully understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20190932DOI Listing

Selective Update of Relevant Eigenspaces for Integrative Clustering of Multimodal Data.

IEEE Trans Cybern 2020 May 20;PP. Epub 2020 May 20.

One of the major problems in cancer subtype discovery from multimodal omic data is that all the available modalities may not encode relevant and homogeneous information about the subtypes. Moreover, the high-dimensional nature of the modalities makes sample clustering computationally expensive. In this regard, a novel algorithm is proposed to extract a low-rank joint subspace of the integrated data matrix. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/TCYB.2020.2990112DOI Listing

Paper-based Analytical Device for Real-time Monitoring of Egg Hatching in the Model Nematode Caenorhabditis elegans.

ACS Sens 2020 May 26. Epub 2020 May 26.

Caenorhabditis elegans (C. elegans) is an in vivo model known for its easy handling and maintenance and lack of associated ethical issues. The release of chitinase can be used to monitor the egg laying stage in C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acssensors.0c00412DOI Listing

Holey Lamellar High Entropy Oxide as Ultra-Highly Active Heterogeneous Catalyst for Solvent-free Aerobic Oxidation of Benzyl Alcohol.

Angew Chem Int Ed Engl 2020 May 26. Epub 2020 May 26.

Jilin University, Department of Chemistry, 2699 Qianjin Street, 130012, Changchun, CHINA.

The development of noble metal free heterogeneous catalysts is promising for selective oxidation of aromatic alcohols; however, the relatively low conversion of non-noble metal catalysts under solvent-free atmospheric condition greatly restricts their industrial application. Herein, we design ed synthesize a novel holey lamellar high entropy oxide (HEO) Co 0.2 Ni 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202004892DOI Listing

Cannabidiol efficacy and clobazam status: A systematic review and meta-analysis.

Epilepsia 2020 May 26. Epub 2020 May 26.

Department of Neuroscience, Biomedicine, and Movement Science, University of Verona, Verona, Italy.

Objective: To evaluate the potential impact of concomitant clobazam (CLB) use on the efficacy of cannabidiol (CBD) treatment in patients with Dravet syndrome and Lennox-Gastaut syndrome using meta-analytical techniques.

Methods: We searched for randomized, placebo-controlled, single- or double-blinded trials. The proportion of patients who achieved ≥50% reduction from baseline in seizure frequency during the treatment period was assessed according to CLB status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.16546DOI Listing

Synergistic therapeutic efficacy of ebselen and silver ions against multidrug-resistant Acinetobacter baumannii-induced urinary tract infections.

Metallomics 2020 May 26. Epub 2020 May 26.

The First College of Clinical Medical Science, China Three Gorges University, 443000 Yichang, China. and The Institute of Infection and Inflammation, Medical College, China Three Gorges University, 443000 Yichang, China.

Ebselen (EbSe), an organo-selenium compound with well-characterized toxicology and pharmacology, exhibited potent antibacterial activity against glutathione (GSH)-positive bacteria when combined with silver ions (Ag+). In this paper, the strong bactericidal activity of EbSe-Ag+ against multidrug-resistant (MDR) Acinetobacter baumannii has been confirmed, and its efficacy was mainly based on the inhibition of thioredoxin reductase (TrxR) activity and the depletion of the total GSH amount. Moreover, the therapeutic effect of EbSe-Ag+ on urinary tract infection was assessed in a mouse model induced with A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0mt00091dDOI Listing

Development of an LC-MS/MS method for determining 5-MeO-DIPT in dried urine spots and application to forensic cases.

J Forensic Leg Med 2020 May 12;72:101963. Epub 2020 Apr 12.

Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key laboratory of Forensic Medicine, 1347 West Guangfu Road, Shanghai, 200063, China. Electronic address:

Purpose: The dried urine spots (DUSs) technique is increasing continuously as an easy sampling method for monitoring substance abuse due to its advantages of stability and convenience regarding transport and storage. 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a new type of tryptamine hallucinogen, the use of which has been banned in many countries. And according to the previous research, 5-MeO-DIPT is not stable in urine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jflm.2020.101963DOI Listing

The scientist and the advertisement: in imperial Germany.

Authors:
Joris Mercelis

Hist Sci 2020 May 26:73275320916971. Epub 2020 May 26.

Johns Hopkins University, USA.

In late nineteenth- and early twentieth-century Germany, the integration of product-evaluating certificates and reports () into advertisements triggered repeated condemnations of "advertisement-" (), and scientists and science administrators introduced various restrictions to prevent the appearance of such documents. At the same time, the provision of to private individuals and firms seemed crucial to the success of many private and public laboratories. Some chemical and other professionals, moreover, argued that the authoring and use of could represent a "scientific" and, therefore, ethical practice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0073275320916971DOI Listing

Advances in chemiluminescence and electrogenerated chemiluminescence based on silicon nanomaterials.

Luminescence 2020 May 26. Epub 2020 May 26.

Analytical & Testing Center, Sichuan University, Chengdu, Sichuan, China.

Since 1950, when chemiluminescence (CL) of siloxane upon treatment with strong oxidants was discovered by Kurtz, many silicon-based nanomaterials with different elements, specific molecules, shapes and sizes have been developed as light emitters, energy acceptors, and catalyzers to provide valuable CL and electrogenerated CL (ECL) detection platforms in analytical chemistry fields. This review mainly focuses on the recent development of their mechanisms and sensing methodologies for small molecules, free radicals, ion, enzyme, protein, DNA, cancer cells, and metabolites based on specific reactions such as aptamer sensing and enzymatic reaction. Additionally, the future trend is discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bio.3805DOI Listing

Estimating Environmental Hazard and Risks from Exposure to Per- and Polyfluoroalkyl Substances (PFAS): Outcome of a SETAC Focused Topic Meeting.

Environ Toxicol Chem 2020 May 25. Epub 2020 May 25.

Division of the National Toxicology Program/NIEHS, RTP, NC.

Per- and Polyfluoroalkyl Substances (PFAS) are a group of highly fluorinated synthetic chemicals that were originally developed for uses as surfactants and surface protectors. Increasingly, specific substances of this class are being found in environmental media (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/etc.4784DOI Listing

Volume effects in the TCP for hypoxic and oxygenated tumors.

Med Phys 2020 May 26. Epub 2020 May 26.

Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, Washington, 98195-6043, USA.

Purpose: Clinical studies in radiation therapy with conventional fractionation show a reduction in the tumor control probability (TCP) with an increase in the total and hypoxic tumor volumes. The main objective of this article is to derive an analytical relationship between the TCP and the hypoxic and total tumor volumes. This relationship is applied to clinical data on the TCP reduction with increasing total tumor volume and, also, dose escalation to target tumor hypoxia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mp.14257DOI Listing

A Procedure for Analyzing the Proteomic Proteomics Profile of Schistosoma mansoni Cercariae.

Methods Mol Biol 2020 ;2151:75-84

National Reference Centre for Parasitology, Montreal, QC, Canada.

Schistosomiasis is one of the most important helminthic parasitic infections in the world, with over 700 million people at risk of infection. Species of Schistosoma have a complex life cycle involving the infection of freshwater snails before infecting their mammalian definitive host. Taking about 130,000 lives per annum, S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-0716-0635-3_7DOI Listing
January 2020

The key points in the pre-analytical procedures of blood and urine samples in metabolomics studies.

Metabolomics 2020 May 25;16(6):68. Epub 2020 May 25.

Medical Research Center, Peking University Third Hospital, Haidian District, 49 Huayuan North Road, Beijing, People's Republic of China.

Background: Metabolomics provides measurement of numerous metabolites in human samples, which can be a useful tool in clinical research. Blood and urine are regarded as preferred subjects of study because of their minimally invasive collection and simple preprocessing methods. Adhering to standard operating procedures is an essential factor in ensuring excellent sample quality and reliable results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11306-020-01666-2DOI Listing

Evaluation of analytical and numerical solutions of mass transfer model for breakthrough curves simulation: Co adsorption by hydrogen peroxide-bio-originated composite.

Bioprocess Biosyst Eng 2020 May 25. Epub 2020 May 25.

Department of Water Engineering, College of Agriculture, Shiraz University, 71365, Shiraz, Iran.

Accurate estimation of breakthrough curve (BTC) is required to scale -up the column adsorption process. A mathematical model (unsteady advection-dispersion-diffusion-adsorption equation) was solved analytically and numerically to simulate the dynamic adsorption of Co(II) ions on hydrogen peroxide-modified bone waste. The performance of both analytical and numerical approaches was evaluated under varying initial Co(II) concentrations (25, 50 and 75 mg L), bed heights (3, 6 and 9 cm), flow rates (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00449-020-02379-5DOI Listing

High Throughput Detection of 327 Drugs in Blood by LC-MS-MS with Automated Data Processing1.

J Anal Toxicol 2020 May 23. Epub 2020 May 23.

Victorian Institute of Forensic Medicine (Melbourne, Australia).

The described procedure provides a rapid technique for the detection and semi-quantitation of a large number of drugs in blood. This procedure uses a minimal sample volume and employs a one-step liquid extraction and automated data processing to yield rapid turnaround times. 327 of the most commonly used medicinal and illicit drugs in Australia were selected including various amphetamines, anesthetics, anti-depressants, anti-psychotics, anti-convulsants, benzodiazepines, beta blockers, opioid and non-opioid analgesics, stimulants, THC and a large number of synthetic cannabinoids and other novel psychoactive substances. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jat/bkaa057DOI Listing

Preparation and characterization of novel MWCNTs/Fe-Co doped TNTs nanocomposite for potentiometric determination of sulpiride in real water samples.

Sci Rep 2020 May 25;10(1):8607. Epub 2020 May 25.

Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

Novel multiwalled carbon nanotubes/ Fe-Co doped titanate nanotubes nanocomposite (MWCNTs/Fe-Co doped TNTs) facilitated the charge transfer and enhanced sensitivity and selectivity. Herein, three novel modified carbon paste sensors (CPSs) based on MWCNTs (sensor I), Fe-Co doped TNTs (sensor II) and MWCNTs/Fe-Co doped TNTs composite (sensor III) were fabricated for a simple, low cost and high accuracy electrochemical method for the potentiometric determination of sulpiride (SLP). The sensors exhibited excellent Nernstian slopes 57. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-65592-yDOI Listing

Transitions in wheat endosperm metabolism upon transcriptional induction of oil accumulation by oat endosperm WRINKLED1.

BMC Plant Biol 2020 May 25;20(1):235. Epub 2020 May 25.

Department of Plant Breeding, Swedish University of Agricultural Sciences, SE-23053, Alnarp, Sweden.

Background: Cereal grains, including wheat (Triticum aestivum L.), are major sources of food and feed, with wheat being dominant in temperate zones. These end uses exploit the storage reserves in the starchy endosperm of the grain, with starch being the major storage component in most cereal species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12870-020-02438-9DOI Listing