242 results match your criteria Analytical cellular pathology Amsterdam[Journal]


Effect of Shogaol on the Expression of Intestinal Stem Cell Markers in Experimentally Induced Colitis in BALB/c Mice.

Anal Cell Pathol (Amst) 2019 6;2019:5134156. Epub 2019 Mar 6.

Department of Anatomy and Pathology, College of Veterinary Medicine, University of Sulaimani, Kurdistan, Iraq.

Aim: This study is aimed at investigating the effect of Shogaol, a phenolic constituent of ginger, on dextran sodium sulfate- (DSS-) induced ulcerative colitis (UC) in mice in comparison with 6-thioguanine (6-TG), an immune-suppressant chemotherapeutic medicine used for treatment of ulcerative colitis.

Material & Methods: Thirty-six adult, male and female BALB/c mice were randomly divided into six groups: group 1 (control negative) not exposed to DSS and did not receive any treatment, group 2 (control positive) exposed to DSS but did not receive any treatment, group 3 exposed to DSS and treated by 0.1 mg/kg of 6-thioguanine, and groups 4, 5, and 6 exposed to DSS and treated by 10, 20, and 40 mg/kg b. Read More

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https://www.hindawi.com/journals/acp/2019/5134156/
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http://dx.doi.org/10.1155/2019/5134156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431407PMC
March 2019
3 Reads

Hepatoprotective Potential of against STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway.

Anal Cell Pathol (Amst) 2019 27;2019:7958701. Epub 2019 Feb 27.

Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

Liver inflammation and necrosis are the foremost problems interlinked with diabetes mellitus (DM). The methanolic extract of (MESM) plays a hepatoprotective role in streptozotocin- (STZ-) induced hepatic injury. In this study, STZ exposure induced diabetes that augmented hepatic damage, which was reflected in serum enzyme markers, the cytokine network, and caspase-3 and caspase-9 levels in Group 2. Read More

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http://dx.doi.org/10.1155/2019/7958701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415279PMC
February 2019
1 Read

The Security Rating on Local Ablation and Interventional Therapy for Hepatocellular Carcinoma (HCC) and the Comparison among Multiple Anesthesia Methods.

Anal Cell Pathol (Amst) 2019 19;2019:2965173. Epub 2019 Feb 19.

Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China.

Recently, the interventional therapies are used more often in clinical practice for hepatocellular carcinoma. The most commonly used methodologies include radiofrequency ablation, microwave ablation, laser ablation, and cryotherapy. Most of the interventional operations need local anesthesia combined with intravenous sedation. Read More

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http://dx.doi.org/10.1155/2019/2965173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399555PMC
February 2019
1 Read

ILF2 Directly Binds and Stabilizes CREB to Stimulate Malignant Phenotypes of Liver Cancer Cells.

Anal Cell Pathol (Amst) 2019 10;2019:1575031. Epub 2019 Feb 10.

Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China.

Cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) is overexpressed and has an oncogenic role in hepatocellular carcinoma (HCC). Interleukin enhancer binding factor 2 (ILF2) has become research hotspot in liver cancer recently. However, it is still unclear whether and how CREB and ILF2 interact with each other. Read More

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http://dx.doi.org/10.1155/2019/1575031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387701PMC
February 2019

Downregulation of PTPRK Promotes Cell Proliferation and Metastasis of NSCLC by Enhancing STAT3 Activation.

Anal Cell Pathol (Amst) 2019 29;2019:4265040. Epub 2019 Jan 29.

Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.

Objective: The receptor-type tyrosine-protein phosphatase (PTPRK) is a candidate tumor suppressor involved in the tumorigenesis of various organs. However, its expression and biological roles in non-small-cell lung cancer (NSCLC) have not yet been investigated.

Methods: PTPRK expression in NSCLC tissues and cell lines was examined using real-time PCR and western blotting. Read More

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http://dx.doi.org/10.1155/2019/4265040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374804PMC
January 2019
2 Reads

PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway.

Anal Cell Pathol (Amst) 2019 23;2019:7145198. Epub 2019 Jan 23.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102 Fujian, China.

Objective: To assess the expression levels of exchange protein 1 directly activated by cAMP (Epac1) and phosphodiesterase 4 (PDE4) in rectal carcinoma, and their associations with clinicopathological indexes. In addition, the associations of PDE4 and Epac1 with A-kinase anchor protein 95, connexin 43, cyclin D1, and cyclin E1 were evaluated.

Methods: The PV-9000 two-step immunohistochemistry method was used to determine protein expression in 44 rectal carcinoma tissue samples and 16 paracarcinoma tissue specimens. Read More

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http://dx.doi.org/10.1155/2019/7145198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364102PMC
January 2019
1 Read

HPV , , and mRNA RT-qPCR Assay for Detecting High-Grade Cervical Lesion with Microscope Slides.

Anal Cell Pathol (Amst) 2019 14;2019:9365654. Epub 2019 Jan 14.

Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University, Wonju, Gangwon Province, Republic of Korea.

After breast and colon cancer, cervical cancer is the third most common cancer of women worldwide. Since human papillomavirus (HPV) infection is known to be the predominant cause of cervical cancer, molecular HPV screening is currently used along with cytological and histological examination methods for precancer diagnosis. Nevertheless, the sensitivity of the current HPV test is less than 80%; thus, many cervical cancer cases are not able to be diagnosed by HPV screening alone, and likewise, patients with cervical cancer are often determined to be HPV-negative by the current screening methods. Read More

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https://www.hindawi.com/journals/acp/2019/9365654/
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http://dx.doi.org/10.1155/2019/9365654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350568PMC
January 2019
9 Reads

Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland.

Anal Cell Pathol (Amst) 2018 17;2018:8120579. Epub 2018 Dec 17.

Research Institute, National Cancer Center Research Institute, Goyang 10408, Republic of Korea.

Environmental and genetic factors exert important influences on lifespan and neoplastic transformation. We have previously shown that spontaneous tumors form frequently in mice homozygous for a full-length deletion. In general, mutations of BRCA1 are closely associated with induction of breast and ovarian cancers but are also known to contribute to the incidence of other cancers at a low frequency. Read More

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https://www.hindawi.com/journals/acp/2018/8120579/
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http://dx.doi.org/10.1155/2018/8120579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311772PMC
April 2019
13 Reads

Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield from Lung, Liver, and Kidney Tumors: Implications for Cancer Genomics.

Anal Cell Pathol (Amst) 2018 10;2018:2898962. Epub 2018 Dec 10.

Interventional Radiology Section, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Context: Targeted needle biopsies are increasingly performed for the genetic characterization of cancer. While the nucleic acid content of core needle biopsies after standard pathology processing (i.e. Read More

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http://dx.doi.org/10.1155/2018/2898962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311765PMC
April 2019
5 Reads

Egg Antigen Induces Oncogenic Alterations in Human Prostate Cells.

Anal Cell Pathol (Amst) 2018 9;2018:4675380. Epub 2018 Dec 9.

West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, P.O. Box LG 54, Legon, Accra, Ghana.

Schistosomiasis is a neglected tropical disease that affects 200 million people and accounts for 100,000 deaths annually. In endemic geographical areas, schistosomiasis has been implicated as an etiological agent in the pathogenesis of bladder, colorectal, and renal carcinoma largely due to eggs in tissues that comes with chronic infection. Several studies have also reported cases of association between infection and prostate cancer. Read More

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https://www.hindawi.com/journals/acp/2018/4675380/
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http://dx.doi.org/10.1155/2018/4675380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305059PMC
April 2019
9 Reads
1.758 Impact Factor

Human Cellular Models for the Investigation of Lung Inflammation and Mucus Production in Cystic Fibrosis.

Anal Cell Pathol (Amst) 2018 15;2018:3839803. Epub 2018 Nov 15.

Laboratory of Regenerative and Experimental Medicine, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Chronic inflammation, oxidative stress, mucus plugging, airway remodeling, and respiratory infections are the hallmarks of the cystic fibrosis (CF) lung disease. The airway epithelium is central in the innate immune responses to pathogens colonizing the airways, since it is involved in mucociliary clearance, senses the presence of pathogens, elicits an inflammatory response, orchestrates adaptive immunity, and activates mesenchymal cells. In this review, we focus on cellular models of the human CF airway epithelium that have been used for studying mucus production, inflammatory response, and airway remodeling, with particular reference to two- and three-dimensional cultures that better recapitulate the native airway epithelium. Read More

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http://dx.doi.org/10.1155/2018/3839803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276497PMC
January 2019
1 Read

High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma.

Anal Cell Pathol (Amst) 2018 30;2018:7691704. Epub 2018 Oct 30.

The Department of Radiotherapy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.

Background And Aims: In patients with nasopharyngeal carcinoma (NPC), local treatment failure and distant metastasis contribute largely to poor outcomes. The nasopharynx is an important lymphoid tissue, and NPC tumourigenesis and development are partly attributed to immune system disorders. Human leukocyte antigen F (HLA-F) has shown a close correlation with NPC in many genome-wide association studies (GWASs). Read More

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http://dx.doi.org/10.1155/2018/7691704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232804PMC
January 2019
1.758 Impact Factor

Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation.

Anal Cell Pathol (Amst) 2018 14;2018:6192187. Epub 2018 Oct 14.

Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.

Recently, epidermal growth factor receptor (EGFR) was a key molecule in investigation of lung cancer, and it was a target for a new therapeutic strategy, based on molecular analyses. In this review, we have summarized some issues considering the role of EGFR in lung cancer, its coding gene, and its promoter gene polymorphisms (SNPs) -216G/T and -191C/A in non-small-cell lung cancer (NSCLC). The position of the SNPs indicates their significant role in EGFR regulation. Read More

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https://www.hindawi.com/journals/acp/2018/6192187/
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http://dx.doi.org/10.1155/2018/6192187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204164PMC
December 2018
3 Reads

Staurosporine Induces the Generation of Polyploid Giant Cancer Cells in Non-Small-Cell Lung Carcinoma A549 Cells.

Anal Cell Pathol (Amst) 2018 10;2018:1754085. Epub 2018 Oct 10.

Neuro- and Tumor Cell Biology Group, Department of Nuclear Medicine, University of Bonn, Bonn, Germany.

Cultivation of A549 non-small-cell lung carcinoma (NSCLC) cells in the presence of staurosporine (SSP) leads to a reduction or a lack of proliferation in a concentration-dependent manner. This inhibition of proliferation is accompanied by the generation of polyploid giant cancer cells (PGCCs) that are characterized by cell flattening, increased cell size, polyploidy, and polynucleation as determined by crystal violet staining, BrdU and DiI labelling, and flow cytometry as well as video time-lapse analysis. Continuous SSP treatment of A549 cells can preserve PGCCs for at least two months in a resting state. Read More

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http://dx.doi.org/10.1155/2018/1754085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199859PMC
December 2018
1 Read

Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats.

Anal Cell Pathol (Amst) 2018 20;2018:1270483. Epub 2018 Sep 20.

Department of Rheumatology and Connective Tissue Diseases, Medical University, Jaczewskiego 8 Street, 20-090 Lublin, Poland.

Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was recently reported. Read More

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https://www.hindawi.com/journals/acp/2018/1270483/
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http://dx.doi.org/10.1155/2018/1270483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171262PMC
December 2018
6 Reads
1.760 Impact Factor

PAK5 Induces EMT and Promotes Cell Migration and Invasion by Activating the PI3K/AKT Pathway in Ovarian Cancer.

Anal Cell Pathol (Amst) 2018 2;2018:8073124. Epub 2018 Sep 2.

Department of Obstetrics and Gynecology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai 200092, China.

Ovarian cancer is the most lethal gynecologic cancer and currently ranks fifth in causing cancer-related deaths among women. P21-activated kinase 5 (PAK5) is a newly identified protein that has been indicated to have oncogenic potential. The present study investigated the expression level of PAK5 in clinical ovarian cancer and the functional roles of PAK5 in ovarian cancer progression. Read More

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http://dx.doi.org/10.1155/2018/8073124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139229PMC
December 2018
1 Read

Estramustine Phosphate Inhibits TGF--Induced Mouse Macrophage Migration and Urokinase-Type Plasminogen Activator Production.

Anal Cell Pathol (Amst) 2018 2;2018:3134102. Epub 2018 Sep 2.

Group for Molecular Oncology, Institute for Medical Research, University of Belgrade, Dr. Subotića 4, 11129 Belgrade, Serbia.

Transforming growth factor-beta (TGF-) has been demonstrated as a key regulator of immune responses including monocyte/macrophage functions. TGF- regulates macrophage cell migration and polarization, as well as it is shown to modulate macrophage urokinase-type plasminogen activator (uPA) production, which also contributes to macrophage chemotaxis and migration toward damaged or inflamed tissues. Microtubule (MT) cytoskeleton dynamic plays a key role during the cell motility, and any interference on the MT network profoundly affects cell migration. Read More

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http://dx.doi.org/10.1155/2018/3134102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139214PMC
December 2018
3 Reads

DNA Repair Gene XRCC1 and XPD Polymorphisms and Gastric Cancer Risk: A Case-Control Study Outcome from Kashmir, India.

Anal Cell Pathol (Amst) 2018 26;2018:3806514. Epub 2018 Aug 26.

Department of Biochemistry, University of Kashmir, Srinagar, India.

Coding polymorphisms in several DNA repair genes have been reported to affect the DNA repair capacity and are associated with genetic susceptibility to many human cancers, including gastric cancer. An understanding of these DNA repair gene polymorphisms might assess not only the risk of humans exposed to environmental carcinogens but also their responses to different therapeutical approaches, which target the DNA repair pathway. In the present study, polymorphic variants of two DNA repair genes, XRCC1 Arg399Gln and XPD Lys751Gln, were chosen to be studied in association with gastric cancer susceptibility in the Kashmiri population. Read More

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http://dx.doi.org/10.1155/2018/3806514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129361PMC
December 2018
1.760 Impact Factor

Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features.

Anal Cell Pathol (Amst) 2018 16;2018:9148124. Epub 2018 Aug 16.

Department of Cytology, Rijeka University Hospital Centre, Krešimirova 42, Rijeka, Croatia.

Objective: Adult granulosa cell tumors (AGCTs) represent 2%-5% of all ovarian malignancies. The aim of this study was to analyze clinical and pathohistological parameters and their impact on recurrence, overall, and disease-free survival in FIGO stage I AGCT patients.

Methods: The tumor specimens analyzed in this retrospective study were obtained from a total of 36 patients with diagnosis of ovarian AGCT surgically treated at the Department of Gynecology, Rijeka University Hospital Centre, between 1994 and 2012. Read More

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http://dx.doi.org/10.1155/2018/9148124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116457PMC
December 2018
4 Reads
1.760 Impact Factor

Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition.

Anal Cell Pathol (Amst) 2018 2;2018:7871814. Epub 2018 Aug 2.

Nichi-Asia Life Science Sdn. Bhd., No. 57, Block F, Jalan Teknologi 3/9, Bistari De Kota, Kota Damansara, PJU 5, 47810 Petaling Jaya, Selangor, Malaysia.

Age-associated changes in natural killer (NK) cell population, phenotype, and functions are directly attributed to the risk of several diseases and infections. It is predicted to be the major cause of the increase in mortality. Based on the surface density of CD56, NK cells are subdivided into two types, such as CD56 and CD56 cells, which represent cytokine production and cytotoxicity. Read More

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http://dx.doi.org/10.1155/2018/7871814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098903PMC
December 2018
14 Reads

Cytotoxicity and Antiangiogenic Activity of Agardh and Hauck Ethanolic Extracts.

Anal Cell Pathol (Amst) 2018 6;2018:3709491. Epub 2018 Aug 6.

Department of Biological Sciences, Visayas State University, Visca, 6521-A Baybay City, Leyte, Philippines.

Brown macroalgae species are constantly reported as potential sources of bioactive compounds useful in inhibiting cell proliferation and vascular formation. Thus, this study was conducted to determine and compare the cytotoxic activities of Agardh and Hauck ethanolic extracts against baker's yeast () using the resazurin reduction test (RRT) and investigate their antiangiogenic activity through duck () chorioallantoic membrane (CAM) assay. Both and ethanolic extracts exhibited cytotoxic activities at IC of 530. Read More

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http://dx.doi.org/10.1155/2018/3709491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109477PMC
December 2018
3 Reads

Capping Actin Protein Overexpression in Human Colorectal Carcinoma and Its Contributed Tumor Migration.

Anal Cell Pathol (Amst) 2018 1;2018:8623937. Epub 2018 Aug 1.

Department of Nursing, Min-Hwei College of Health Care Management, Tainan 736, Taiwan.

Objective: Human colorectal cancer (CRC) is the third most common cancer; patients with metastatic colorectal cancer (mCRC) show poor prognosis than those with CRC cases. There are no reliable molecular biomarkers for the diagnosis of CRC prognosis except with pathological features. Therefore, it is urgent to develop a biomarker for diagnosis and/or prediction of human CRC. Read More

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http://dx.doi.org/10.1155/2018/8623937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093051PMC
December 2018
1 Read

Comparison of Syndecan-1 Immunohistochemical Expression in Lobular and Ductal Breast Carcinoma with Nodal Metastases.

Anal Cell Pathol (Amst) 2018 29;2018:9432375. Epub 2018 Jul 29.

Department of Pathology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia.

Syndecan-1 (Sdc1) is a transmembrane heparan sulfate proteoglycan, an extracellular matrix receptor involved in intercellular communication, proliferation, angiogenesis, and metastasis. This study determined and compared Sdc1 expression in the tumor cells and stroma of 30 invasive lobular and 30 invasive ductal breast carcinomas (ILCs/IDCs), also in the axillary node metastases of ductal type, and correlated it with clinical and tumor parameters. Sdc1 was expressed in the epithelium of 90% carcinoma of both histological types. Read More

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http://dx.doi.org/10.1155/2018/9432375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087611PMC
December 2018

Traditional Chinese Medicine Extract from Huaier Increases the Expression of Duffy Antigen Receptor for Chemokines and Reduces the Expression of Its Ligands.

Anal Cell Pathol (Amst) 2018 24;2018:6756092. Epub 2018 Jul 24.

Department of Breast Surgery, Guangdong Traditional Chinese Medicine Hospital, Guangzhou, Guangdong 510000, China.

Aims: The aim of the present study is to investigate whether the aqueous extract from Huaier, a traditional Chinese medicine (TCM), can affect the expression of Duffy antigen receptor for chemokines (DARC) and its ligands. Moreover, we compare the status of DARC in primary and metastatic breast cancer tissues from the same patient.

Methods: Immunohistochemistry was used to detect the expression of DARC in primary and metastatic focuses in 30 patients with breast cancer. Read More

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http://dx.doi.org/10.1155/2018/6756092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081536PMC
December 2018
3 Reads

An Overlapping Cell Image Synthesis Method for Imbalance Data.

Anal Cell Pathol (Amst) 2018 9;2018:7919503. Epub 2018 Jul 9.

Harbin University of Science and Technology, Harbin 150080, China.

DNA ploidy analysis of cells is an automation technique applied in pathological diagnosis. It is important for this technique to classify various nuclei images accurately. However, the lack of overlapping nuclei images in training data (imbalanced training data) results in low recognition rates of overlapping nuclei images. Read More

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http://dx.doi.org/10.1155/2018/7919503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069585PMC
October 2018
1 Read

Positive Association between Gene and Susceptibility to Idiopathic Scoliosis in Bulgarian Population.

Anal Cell Pathol (Amst) 2018 18;2018:6836092. Epub 2018 Jul 18.

Graduate School for Science and Engineering, Saitama University, 255 Shimookubo, Sakura-ku, Saitama 338-8570, Japan.

Idiopathic scoliosis (IS) is a common medical condition beginning in childhood and characterized by strong evidence for a genetic susceptibility to three-dimensional spinal deformity. The primary goal of the current case-control study is to examine the association between the (-509C/T) functional polymorphic variant and genetic predisposition to IS in the Bulgarian population and the genotype-phenotype correlations in distinct case-control subgroups based on age at onset, family history, and gender. A total of 127 patients with primary scoliosis and 254 gender-matched control subjects were recruited. Read More

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http://dx.doi.org/10.1155/2018/6836092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069583PMC
October 2018
7 Reads
1.760 Impact Factor

The Role of Abnormal Methylation of Wnt5a Gene Promoter Regions in Human Epithelial Ovarian Cancer: A Clinical and Experimental Study.

Anal Cell Pathol (Amst) 2018 16;2018:6567081. Epub 2018 Jul 16.

The Shenzhen Maternity & Child Healthcare Hospital Affiliated to Southern Medical University, ShenZhen 518028, China.

Objective: In the current study, the role of abnormal methylation of Wnt5a gene promoter regions in human epithelial ovarian cancer was investigated.

Methods: Wnt5a expressions were examined by immunohistochemistry in epithelial ovarian tissues (30 normal and 79 human EOC tissues). SKOV3 cells were treated with different concentrations of 5-Aza-CdR (0. Read More

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https://www.hindawi.com/journals/acp/2018/6567081/
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http://dx.doi.org/10.1155/2018/6567081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069701PMC
October 2018
12 Reads

Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors.

Anal Cell Pathol (Amst) 2018 12;2018:1204549. Epub 2018 Jul 12.

Department of Conservative Dentistry and Endodontics, Daswani Dental College and Research Centre, Kota, India.

Growth factors like bone morphogenetic protein 4 (BMP4) and fibroblast growth factor 8 (FGF8) play a major role in organogenesis and specifically in odontogenesis. They are also believed to have a role in oncogenesis. Thus, any discrepancies in their standard behavior and activity would lead to serious abnormalities including odontogenic cyst and tumors. Read More

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http://dx.doi.org/10.1155/2018/1204549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069700PMC
October 2018
1 Read

Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury.

Anal Cell Pathol (Amst) 2018 8;2018:8764384. Epub 2018 Jul 8.

Renal Research Lab, Centre for Bio-Medical Research, School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore 632014, India.

Over the years, the epigenetic landscape has grown increasingly complex. Until recently, methylation of DNA and histones was considered one of the most important epigenetic modifications. However, with the discovery of enzymes involved in the demethylation process, several exciting prospects have emerged that focus on the dynamic regulation of methylation and its crucial role in development and disease. Read More

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https://www.hindawi.com/journals/acp/2018/8764384/
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http://dx.doi.org/10.1155/2018/8764384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057397PMC
October 2018
23 Reads

LncRNA LOXL1-AS1 Promotes the Proliferation and Metastasis of Medulloblastoma by Activating the PI3K/AKT Pathway.

Anal Cell Pathol (Amst) 2018 27;2018:9275685. Epub 2018 Jun 27.

Department of Pediatrics, Jining No. 1 People's Hospital, Shandong, China.

Medulloblastoma is the most common malignant brain tumor of childhood, with great potential to metastasize. However, the mechanisms of how medulloblastoma develops and progresses remain to be elucidated. The present study assessed the role of long noncoding RNA LOXL1-AS1 (lncRNA LOXL1-AS1) in the cell proliferation and metastasis in human medulloblastoma. Read More

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http://dx.doi.org/10.1155/2018/9275685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040304PMC
October 2018
5 Reads

Metformin Treatment Inhibits Motility and Invasion of Glioblastoma Cancer Cells.

Anal Cell Pathol (Amst) 2018 26;2018:5917470. Epub 2018 Jun 26.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon.

Glioblastoma multiforme (GBM) is one of the most common and deadliest cancers of the central nervous system (CNS). GBMs high ability to infiltrate healthy brain tissues makes it difficult to remove surgically and account for its fatal outcomes. To improve the chances of survival, it is critical to screen for GBM-targeted anticancer agents with anti-invasive and antimigratory potential. Read More

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http://dx.doi.org/10.1155/2018/5917470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038689PMC
October 2018
5 Reads

Class III -Tubulin Overexpression Induces Chemoresistance to Eribulin in a Leiomyosarcoma Cell Line.

Anal Cell Pathol (Amst) 2018 21;2018:8987568. Epub 2018 Jun 21.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City 812-8582, Japan.

Eribulin is a new drug to treat soft tissue sarcoma (STS) that exerts antitumor activity by binding to microtubules. The prognosis of STS is poor, and eribulin is expected to improve the treatment outcome. We observed several cases that exhibited resistance to eribulin and developed an eribulin-resistant leiomyosarcoma cell line to investigate the mechanism of resistance. Read More

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http://dx.doi.org/10.1155/2018/8987568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033248PMC
October 2018
6 Reads

Heparan Sulfate Proteoglycans in Human Colorectal Cancer.

Anal Cell Pathol (Amst) 2018 20;2018:8389595. Epub 2018 Jun 20.

Disciplina de Biologia Molecular, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Três de Maio, 100 4° Andar, Vila Clementino, São Paulo, SP, Brazil.

Colorectal cancer is the third most common cancer worldwide, accounting for more than 610,000 mortalities every year. Prognosis of patients is highly dependent on the disease stage at diagnosis. Therefore, it is crucial to investigate molecules involved in colorectal cancer tumorigenesis, with possible use as tumor markers. Read More

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http://dx.doi.org/10.1155/2018/8389595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031075PMC
October 2018

Erythrocyte Senescence in a Model of Rat Displaying Hutchinson-Gilford Progeria Syndrome.

Anal Cell Pathol (Amst) 2018 29;2018:5028925. Epub 2018 May 29.

Department of Biochemistry, University of Allahabad, Allahabad 211002, India.

Background: Increased oxidative stress is a major cause of aging and age-related diseases. Erythrocytes serve as good model for aging studies. Dihydrotachysterol is known to induce premature aging feature in rats mimicking Hutchinson-Gilford progeria syndrome. Read More

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http://dx.doi.org/10.1155/2018/5028925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996419PMC
October 2018
3 Reads

Anticancer Effects of Dihydroartemisinin on Human Esophageal Cancer Cells In Vivo.

Anal Cell Pathol (Amst) 2018 17;2018:8759745. Epub 2018 May 17.

Department of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.

Despite recent advances in chemotherapy and surgical resection, the 5-year survival rate of esophageal cancer still remains at the low level. Therefore, it is very important to discover a new agent to improve the life expectancy of patients with esophageal cancer. Dihydroartemisinin (DHA), a semisynthetic derivative of artemisinin, has recently exhibited promising anticancer activity against various cancer cells. Read More

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https://www.hindawi.com/journals/acp/2018/8759745/
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http://dx.doi.org/10.1155/2018/8759745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985077PMC
October 2018
4 Reads

Overexpression of the Oncogenic Variant (KLF6-SV1) in Young NPC Patients and Correlation with Lack of E-Cadherin.

Anal Cell Pathol (Amst) 2018 19;2018:9654067. Epub 2018 Apr 19.

Laboratoire d'Ingénierie des Protéines et des Molécules Bioactives, Institut National des Sciences Appliquées et de Technologie (INSAT), Tunis, Tunisia.

Purpose: The transcription factor Krüppel-like factor 6 (KLF6) regulates various cellular functions, such as metabolism, cell proliferation, and differentiation. KLF6 plays a key role in the development and progression of multiple human cancers.

Methods: Fifty primary biopsies and 10 normal nasopharyngeal mucosae were used to analyze by RT-QPCR the expression and the copy number of wtKLF6 and the spliced variants (KLF6-SV1, KLF6-SV2, and KLF6-SV3) in Tunisian patients with nasopharyngeal carcinoma. Read More

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http://dx.doi.org/10.1155/2018/9654067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964540PMC
October 2018
8 Reads

Polysaccharides Attenuate Oxidative Stress and Inflammation in Macrophages through miR-155.

Anal Cell Pathol (Amst) 2018 2;2018:5762371. Epub 2018 May 2.

Ward Thirty-Three, Department of Emergency Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Aim: To investigate the function of polysaccharides (TFPS) in LPS-induced inflammation and oxidative stress of macrophages.

Methods: RAW264.7 cells were pretreated with TFPS and then stimulated with 0. Read More

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http://dx.doi.org/10.1155/2018/5762371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954968PMC
October 2018
3 Reads

The Role of Immune Defects and Colonization of in the Pathogenesis of Atopic Dermatitis.

Anal Cell Pathol (Amst) 2018 2;2018:1956403. Epub 2018 May 2.

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.

Atopic dermatitis (AD) is a condition with a complex and not fully understood etiology. In patients with AD, acute skin lesions are colonized by a greater number of () bacteria than chronic lesions, clinically unchanged atopic skin, or the skin of healthy people. Mechanisms promoting skin colonization by include complex interactions among several factors. Read More

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https://www.hindawi.com/journals/acp/2018/1956403/
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http://dx.doi.org/10.1155/2018/1956403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954962PMC
October 2018
14 Reads

Differences in E-Cadherin and Syndecan-1 Expression in Different Types of Ameloblastomas.

Anal Cell Pathol (Amst) 2018 23;2018:9392632. Epub 2018 Apr 23.

Molecular Pathology Area, School of Dentistry, University of the Republic, Montevideo, Uruguay.

Ameloblastomas are a group of benign, locally aggressive, recurrent tumors characterized by their slow and infiltrative growth. E-Cadherin and syndecan-1 are cell adhesion molecules related to the behavior of various tumors, including ameloblastomas. Ninety-nine ameloblastoma samples were studied; the expression of E-cadherin and syndecan-1 were evaluated by immunohistochemistry. Read More

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http://dx.doi.org/10.1155/2018/9392632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937611PMC
October 2018
4 Reads

Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases.

Anal Cell Pathol (Amst) 2018 10;2018:8651790. Epub 2018 Apr 10.

Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

The expression of caveolin-1 (CAV1) in both tumor cell and cancer-associated fibroblasts (CAFs) has been found to correlate with tumor aggressiveness in different epithelial tumor entities, whereas less is known for caveolin-2 (CAV2). The aim of this study was to investigate the clinicopathological significance and prognostic value of stromal CAV1 and CAV2 expression in lung cancer. The expression of these two genes was investigated at protein level on a tissue microarray (TMA) consisting of 161 primary tumor samples. Read More

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http://dx.doi.org/10.1155/2018/8651790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914130PMC
October 2018

Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits.

Anal Cell Pathol (Amst) 2018 4;2018:6430696. Epub 2018 Apr 4.

Laboratory of Cellular and Molecular Biology, Team of ECM Remodeling Biochemistry, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, BP 32, EL Alia, 16111 Algiers, Algeria.

Early weight gain induced by high-fat diet has been identified as a predictor for cardiac disease, one of the most serious public health problems. Our goal is to study the influence of a HFD on biochemical, oxidant stress parameters, and the cardiac ultrastructure in both male and female prepubertal models. Experiments were carried on 24 prepubertal New Zealand white rabbits, randomly assigned to male and female control (MC and FC, resp. Read More

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https://www.hindawi.com/journals/acp/2018/6430696/
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http://dx.doi.org/10.1155/2018/6430696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904822PMC
October 2018
9 Reads

Angiodrastic Chemokines in Colorectal Cancer: Clinicopathological Correlations.

Anal Cell Pathol (Amst) 2018 16;2018:1616973. Epub 2018 Apr 16.

Gastroenterology Research Laboratory, University of Crete Medical School, Heraklion, Greece.

Aim: To study the expression of angiodrastic chemokines in colorectal tumors and correlate findings with clinicopathological parameters and survival.

Methods: The proangiogenic factor VEGF, the angiogenic chemokines CXCL8 and CXCL6, and the angiostatic chemokine CXCL4 were measured by ELISA in tumor and normal tissue of 35 stage II and III patients and correlated with the histopathology markers Ki67, p53, p21, bcl2, EGFR, and MLH1 and 5-year survival. The Wilcoxon and chi-square tests were used for statistical comparisons. Read More

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http://dx.doi.org/10.1155/2018/1616973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926520PMC
October 2018

Prognostic Significance of Cyclins A2, B1, D1, and E1 and Numerical Aberrations in Oral Squamous Cell Carcinomas.

Anal Cell Pathol (Amst) 2018 27;2018:7253510. Epub 2018 Mar 27.

Pathology Department, School of Medicine-University Clinical Hospital, University of Santiago de Compostela, CP 15706 Santiago, Spain.

We analysed the expression of cyclins A2, B1, D1, and E1 by immunohistochemistry and numerical aberrations in gene by fluorescence in situ hybridization technique in 67 primary oral squamous cell carcinomas (OSCC). Cyclin A2 expression was observed in 54 (83.1%) tumours, cyclin D1 in 58 (89. Read More

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http://dx.doi.org/10.1155/2018/7253510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892296PMC
October 2018
11 Reads

High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis.

Anal Cell Pathol (Amst) 2018 20;2018:2989635. Epub 2018 Mar 20.

Department of Anatomy, Medical School of Patras, 26504 Patras, Greece.

Focal adhesion signaling to actin cytoskeleton is critically implicated in cell migration and cancer invasion and metastasis. Actin-binding proteins cofilin and N-WASP regulate actin filament turnover, and focal adhesion proteins parvins and PINCH mediate integrin signaling to the actin cytoskeleton. Altered expression of these proteins has been implicated in human cancer. Read More

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http://dx.doi.org/10.1155/2018/2989635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884441PMC
October 2018
1 Read

Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary.

Anal Cell Pathol (Amst) 2018 15;2018:1289103. Epub 2018 Mar 15.

Laboratorio de Genómica Aplicada, Departamento de Oncología Básica y Clínica, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

The progressive decline of the ovarian follicle pool leads to reproductive ageing. The latter is accompanied by age-related disorders, including various types of cancer. In fact, the highest rates of ovarian cancer (OC) occur at postmenopause while OC risk is significantly modulated by parity records during previous fertile life. Read More

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http://dx.doi.org/10.1155/2018/1289103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874974PMC
October 2018
2 Reads

Identification of Malignancy-Associated Changes in Histologically Normal Tumor-Adjacent Epithelium of Patients with HPV-Positive Oropharyngeal Cancer.

Anal Cell Pathol (Amst) 2018 11;2018:1607814. Epub 2018 Mar 11.

British Columbia Cancer Research Centre, Department of Integrative Oncology, Vancouver, BC, Canada.

The incidence of HPV-positive oropharyngeal cancer (HPV+ OPC) is increasing, thus presenting new challenges for disease detection and management. Noninvasive methods involving brush biopsies of diseased tissues were recently reported as insufficient for tumor detection in HPV+ OPC patients, likely due to differences between the site of tumor initiation at the base of involuted crypts and the site of brush biopsy at the crypt surface. We hypothesized that histologically normal surface epithelial cells in the oropharynx contain changes in nuclear morphology that arise due to tumor proximity. Read More

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http://dx.doi.org/10.1155/2018/1607814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866869PMC
October 2018

Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma.

Anal Cell Pathol (Amst) 2018 7;2018:9718585. Epub 2018 Mar 7.

Policlinico Umerto I, II Division of Internal Medicine and Geriatrics, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.

Hemangiopericytoma (HPT) is a rare mesenchymal tumor of fibroblastic type and for its rarity is poorly studied. The most common sites of metastatic disease in patients with intracranial HPT are the bone, liver, and lung, suggestive for an hematogenous dissemination; for this reason, we investigated, for the first time, the presence of circulating tumor cells (CTCs) in hemangiopericytoma patient by CellSearch® and SceenCell® devices. Peripheral blood samples were drawn and processed by CellSearch, an EpCAM-dependent device, and ScreenCell®, a device size based. Read More

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https://www.hindawi.com/journals/acp/2018/9718585/
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http://dx.doi.org/10.1155/2018/9718585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863319PMC
October 2018
7 Reads

MicroRNA-378 Promotes Osteogenesis-Angiogenesis Coupling in BMMSCs for Potential Bone Regeneration.

Anal Cell Pathol (Amst) 2018 1;2018:8402390. Epub 2018 Mar 1.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Bone tissue regeneration was closely associated with osteogenesis and angiogenesis. The harmonious regulation of osteogenetic and angiogenic growth factors would enhance bone regeneration, while the imbalance of that would lead to local excessive bone formation or vascular mass due to exogenous delivery. Therefore, microRNA is believed to regulate multiple metabolism progress through endogenous signaling pathways on the gene level. Read More

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http://dx.doi.org/10.1155/2018/8402390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852880PMC
October 2018
3 Reads

Molecular Detection of EMT Markers in Circulating Tumor Cells from Metastatic Non-Small Cell Lung Cancer Patients: Potential Role in Clinical Practice.

Anal Cell Pathol (Amst) 2018 27;2018:3506874. Epub 2018 Feb 27.

Department of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

Background: Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related mortality; nevertheless, there are few data regarding detection of circulating tumor cells (CTCs) in NSCLC, compared to other kinds of cancers in which their prognostic roles have already been defined. This difference is likely due to detection methods based on the epithelial marker expression which ignore CTCs undergoing epithelial-mesenchymal transition (CTCs).

Methods: After optimization of the test with spiking experiments of A549 cells undergoing TGF-1-induced EMT (A549), the CTCs were enriched by immunomagnetic depletion of leukocytes and then characterized by a RT-PCR assay based on the retrieval of epithelial and EMT-related genes. Read More

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https://www.hindawi.com/journals/acp/2018/3506874/
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http://dx.doi.org/10.1155/2018/3506874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848062PMC
October 2018
2 Reads