189 results match your criteria Analytical and quantitative cytopathology and histopathology[Journal]


Gentian Violet Used as an Epithelial Cell Monolayer Stain in the Scratch Wound Healing Assay.

Authors:
César Rivera

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):137-8

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April 2016
5 Reads
1 Citation

Malignant Bilateral Basifrontal Solitary Fibrous Tumor. A Case Report.

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):133-6

Background: Solitary fibrous tumors are rare benign mesenchymal neoplasms characterized by involvement of many sites all over the body with uncommon presentation within the cranium. Furthermore, malignant bilateral basifrontal solitary fibrous tumor is extremely rare. Although uncommon, this rare entity may be included in the differential diagnosis of frontal tumors in adults, to ensure complete surgical resection. Read More

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April 2016
13 Reads

Influence of Radiation Exposure During Radiotherapy. Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations.

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):126-32

Objective: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy.

Study Design: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. Read More

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April 2016
5 Reads

Effect of Zoledronic Acid Application on Different Graft Materials in Calvarial Bone Defect Models. An Experimental Analysis.

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):117-25

Objective: To determine the effect of zoledronic acid on graft materials in bone calvarial defects.

Study Design: Eighty adult (12 weeks) Sprague-Dawley male rats weighing from 300-350 g were divided into groups: calvarial defect, calvarial defect + synthetic graft, and calvarial defect + xenograft. All groups received zoledronate intravenously for a week after surgery and were sacrificed at either 6 or 12 weeks after their operation. Read More

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April 2016
8 Reads

Effects of Potentilla fulgens as a Prophylactic Agent in Tibial Defects in Rats.

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):111-6

Objective: To investigate the effects of Potentilla fulgens as a prophylactic agent on tibial defects in the rat.

Study Design: Twenty-eight male Wistar albino rats weighing 200-215 g each were divided into 3 experimental groups. The tibial bone defect group served as the control group. Read More

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April 2016
14 Reads

Effects of Cyclooxygenase on the Urothelium of the Urinary Bladder of Mice Exposed to Pelvic Radiation.

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):103-10

Objective: To determine the role of cyclooxygenase (COX) expression in the urothelium of the urinary bladder during radiation injury caused by pelvic radiotherapy for cancer therapy.

Study Design: Twenty-four male Swiss Albino mice were separated into 4 groups. The first group was the control group (Group 1) and the second, third, and fourth groups were euthanized after 24 hours (Group 2), 48 hours (Group 3), and 7 days (Group 4), respectively. Read More

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April 2016
5 Reads

Effects of Low-Intensity Treadmill Exercise on Sciatic Nerve in Experimental Diabetic Neuropathy.

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):95-102

Objective: To investigate the potential beneficial effects of low-intensity exercise on histopathological changes of sciatic nerves in streptozotocin (STZ)-induced diabetic rats.

Study Design: The rats were allotted randomly into 3 experimental groups: A (control), B (diabetic untreated), and C (diabetic treated with low-intensity exercise); each group contained 8 animals. Groups B and C received STZ. Read More

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April 2016
10 Reads
1 Citation

Protective Effects of Vitamin E on Methotrexate-Induced Jejunal Mucosal Damage in Rats.

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):87-94

Objective: To investigate the possible protective effects of Vitamin E (Vit E) on oxidative stress and jejunal damage in the rat intestinal mucosa after methotrexate (MTX)-induced enterotoxicity.

Study Design: Rats were divided into 3 groups: control, MTX, and MTX+ Vit E; each group contained 8 animals. The control group was given physiological serum in addition to sunflower oil for 3 days. Read More

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April 2016
5 Reads

Immunohistochemical Expression and Clinical Significance of Wnt11 and BCL2A1 in Complete Moles.

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):79-86

Objective: To investigate Wnt11 and BCL2A1 immunohistochemical expression in complete moles and normal villi.

Study Design: The expression of Wnt11 and BCL2A1 in 84 complete moles and 30 normal first-trimester villi were detected by Envision immunohistochemistry. Quantitative evaluation according to color deconvolution and immunoreactive score was performed. Read More

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April 2016
8 Reads

Distribution and Developmental Changes of Neuropeptide Y and Its Y1 Receptor-like Immunoreactive Cells in the Duck Thymus.

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):70-8

Objective: To investigate the distribution and developmental changes of Neuropeptide-Y (NPY) and its Y1 receptor (NPYY1)-like immunoreactivity cells in the duck thymus using immunohistochemistry associated with morphological analysis.

Study Design: Studies were carried out on Tianfu ducks on days 14, 18, 22, and 26 of embryogenesis (E14, E18, E22, and E26) as well as at 0 (neonatal stage), 1, 3, 5, 8, 11, 14, 17, 20, 26, 29, and 32 weeks of postnatal development (P0, P1, P3, P5, P8, P11, P14, P17, P20, P26, P29, and P32).

Results: NPY-like immunoreactivity (NPY-ir) was detected mainly in the epithelial reticular cells and vascular smooth muscles, slightly in the lymphocytes from E26 onwards. Read More

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April 2016
11 Reads

Automated Region-based Prostate Cancer Cell Nuclei Localization. Part of a Prognostic Modality Tool for Prostate Cancer Patients.

Anal Quant Cytopathol Histpathol 2016 Apr;38(2):59-69

Background: Prostate cancer is a disease of disrupted cell genomes. Quantification of DNA from cytology preparations can yield prognostic information about tissue biological behaviors; however, this process is very labor-intensive to perform. Quantitative digital pathology can measure the structural chromatin changes associated with neoplasia and can enable prognostic and predictive assays based on imaging of sectioned prostate tissue. Read More

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April 2016
7 Reads

Another Case of Multifocal Blue Nevus of the Prostate.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):57-8

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February 2016
7 Reads

Inverted Papilloma of the Bladder Coexisting with Urothelial Carcinoma. A Case Report.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):52-6

Background: Inverted papilloma (IP) is an unusual benign neoplasm, most commonly found in the bladder. Cases of malignant transformation have been reported in the past, although most of them are now considered to be urothelial carcinomas with an inverted growth pattern.

Case: A 54-year-old man was diagnosed with urothelial carcinoma in situ (UCIS), high-grade papillary urothelial carcinoma (HGPUC), and IP by transurethral resection specimen of the bladder. Read More

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February 2016
28 Reads

Role of Quercetin in Cadmium-Induced Oxidative Stress, Testicular Damage, and Apoptosis in Rats.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):45-51

Objective: The aim of this study was to investigate the role of quercetin on cadmium-induced oxidative stress, testicular damage, and apoptosis in rat testes.

Study Design: The rats were randomly allotted into 1 of 3 experimental groups: control, cadmium-treated, and cadmium-treated with quercetin; each group con- tained 10 animals. Control animals received daily injec- tions of the saline vehicle alone. Read More

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February 2016
7 Reads

Diagnostic Value of Urine Cytology in Bladder Cancer. A Meta-Analysis.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):38-44

Objective: To evaluate the diagnostic value of urine cytology in detecting bladder cancer using meta-analysis.

Study Design: Public databases, including PubMed, Embase, Springer, Elsevier Science Direct, Cochrane Library, and Google Scholar, were searched before February 2015. Sensitivity, specificity, positive likelihood ratio (LR), negative LR, and diagnostic odds ratio (DOR) of urine cytology in individual studies were calculated using random effects model or fixed effect model. Read More

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February 2016
7 Reads

High Incidence of Incidental Prostate Cancer in Transurethral Resection of Prostate Specimens in China. The Value of Pathologic Review.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):31-7

Objective: To identify the incidence and clinicopathologic features of prostate cancer incidentally detected in patients undergoing transurethral resection of the prostate (TURP) for benign prostatic hyperplasia (BPH), and to estimate the clinical value of pathologic review of all TURP specimens.

Study Design: A pathologic review was performed on all TURP specimens for each patient from May 1, 2004, to June 30, 2014, in our institute. A total of 1,024 men (ages 46-98) were identified by pathology specimen. Read More

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February 2016
54 Reads

Prognostic Significance of Mitotic Activity in Noninvasive, Low-Grade, Papillary Urothelial Carcinoma.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):23-30

Objective: To identify the most useful method to detect the mitotic count (MC) by comparing different techniques, to determine a cutoff value for mitotic activity (MA), and to evaluate the correlation of this value with the recurrence of noninvasive low-grade papillary urothelial neoplasm (LGPUC).

Study Design: Hematoxylin and eosin-stained slides of 55 LGPUC cases were evaluated for their MA. MC was determined using 4 different methods. Read More

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February 2016
4 Reads

Effects of Nicotine on Rat Tongue Mucosa. Histopathological and Immunohistochemical Analyses.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):17-22

Objective: To evaluate the histopathological and immunohistochemical effects of systemically administered nicotine on rat tongue mucosa.

Study Design: Rats were assigned to one of two groups: the experimental group received nicotine systemically (nicotine sulphate 2 mg/kg subcutaneously daily for 28 days), while the rats in the control group were administered physiological saline (1.5 mL subcutaneously for 28 days). Read More

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February 2016
9 Reads

Significance of Number and Localization of Positive Core Biopsies for the Identification of Prostate Cancer Eligible for Active Surveillance.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):9-16

Objective: Prostate cancer (PCa) patients fulfilling the Epstein criteria for insignificant disease are eligible for the treatment option of active surveillance (AS). Using the combined histological and cytological grading (Gleason/Helpap score), we aimed to investigate the significance of biopsy localization and tumor involvement in core needle biopsies as discriminators for insignificant cancer.

Study Design: Primary prostate biopsies of 1,285 patients were analyzed by the combined histological and cytological grading with regard to biopsy localization and tumor involvement per core. Read More

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February 2016
3 Reads

Value of p16(INK4a) and Ki-67 Immunohistochemical Staining in Cervical Intraepithelial Neoplasia Grade 2 Biopsies as Biomarkers for Cervical Intraepithelial Neoplasia Grade 3 in Cone Results.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):1-8

Objective: To evaluate the usefulness of p16(INK4a) (p16) and Ki-67 staining in high-grade cervical intraepithelial neoplasia (CIN2) biopsies in order to predict CIN3 results in cone specimens, thereby sparing those not likely at risk for CIN3 from unnecessary cone excision.

Study Design: We retrospectively recruited patients with CIN2 colposcopy-directed biopsy treated by loop electrosurgical excision procedure. The expression of p16 and Ki-67 was qualitatively and quantitatively analyzed in all biopsies and cone specimens. Read More

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February 2016
10 Reads

Renal Leiomyosarcoma. A Report of Two Cases.

Anal Quant Cytopathol Histpathol 2015 Dec;37(6):369-74

Background: Leiomyosarcoma represents a rather uncommon malignancy, and reports of cases characterized by a renal genesis are particularly rare.

Cases: We describe 2 cases of leiomyosarcoma of the kidney, in a 63-year-old woman and in a 53-year-old man, respectively. Both tumors share a common immunohistochemical profile with a strong positivity for smooth muscle actin, a focal positivity for desmin, and negativity for cytokeratins and other markers. Read More

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December 2015
7 Reads

Extravesical Pagetoid Spread of Urothelial Carcinoma in Situ. A Report of Five Cases.

Anal Quant Cytopathol Histpathol 2015 Dec;37(6):364-8

Background: Urothelial carcinoma in situ (CIS) of the bladder is classified as a flat lesion of the urothelium; it has a tendency to be multifocal and carries a high risk of recurrence and persistence. Approximately one-third of patients with urothelial CIS of the bladder develop invasive carcinoma if left untreated. There are a few reported cases of extravesical intramucosal extension (pagetoid spread) of urothelial CIS without prior documentation of primary muscle-invasive carcinoma. Read More

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December 2015
1 Read

Clinicopathological Significance of Matrix Metalloproteinase-2 Protein Expression in Renal Cell Carcinoma Patients.

Anal Quant Cytopathol Histpathol 2015 Dec;37(6):353-63

Objective: To conduct a metaanalysis in order to determine the association between matrix metalloproteinase (MMP)-2 expression and renal cell carcinoma (RCC) progression.

Study Design: Cohort studies were identified after an exhaustive search of the following electronic databases: PubMed, China Biomedicine, Web of Science, Wanfang database, and China National Knowledge Infrastructure. Summary odds ratios with 95% confidence interval were calculated. Read More

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December 2015
11 Reads

Evaluation of Cytogenetic and Genotoxic Effects of Oxalic Acid by the Alkaline Comet Assay and QRT PCR in Human Buccal Epithelial Cells.

Anal Quant Cytopathol Histpathol 2015 Dec;37(6):347-52

Objective: To evaluate the cytogenetic and genotoxic effects of oxalic acid.

Study Design: Buccal epithelial cells were obtained and cells were suspended in phosphate buffered saline. Increasing amounts of oxalic acids were added to cell suspensions and incubated in 37 degrees C, 5% CO2 for 30 minutes. Read More

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December 2015
1 Read

Noninvasive Tumor Grading of Glioblastomas Before Surgery Using Arterial Spin Labeling. A Cohort Study.

Anal Quant Cytopathol Histpathol 2015 Dec;37(6):339-46

Objective: To assess the clinical value of using arterial spin labeling (ASL) technique preoperatively for non-invasive tumor grading in glioblastoma (GBM) patients.

Study Design: Forty-nine patients with GBMs were selected, including 21 patients with high-grade gliomas and 28 patients with low-grade gliomas. ASL perfusion imaging was performed with GE Signa Excite HD 3. Read More

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December 2015
2 Reads

Morphometric Analysis in the Diagnosis of Low-Grade Ductal and Lobular Carcinoma in Situ of the Breast.

Anal Quant Cytopathol Histpathol 2015 Dec;37(6):331-8

Objective: To identify quantitative histological features that can differentiate between low grade ductal carcinoma in situ (LG-DCIS) and classic type lobular carcinoma in situ (C-LCIS).

Study Design: Regions of solid intraductal proliferation from scanned hematoxylin and eosin images of LG-DCIS (20 cases) and C-LCIS (25 cases) were analyzed using Mercator Version 1.0 (ExploraNova, La Rochelle, France). Read More

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December 2015
4 Reads

Tumor-like Accumulation of Uromodulin (Tamm-Horsfall Glycoprotein) in the Ureter. A Case Report of a Possible Diagnostic Pitfall.

Anal Quant Cytopathol Histpathol 2015 10;37(5):326-9

Background: Uromodulin, also known as Tamm-Horsfall glycoprotein (THG), is the most abundantly produced protein appearing in normal urine. Under normal conditions it has several functions, the most important being the provision of a water-tight boundary to the end path of filtration and the prevention of urinary tract infections. Under certain conditions THG is accumulated in urinary tract organs and the deposition is most often clinically silent. Read More

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October 2015

Arteriovenous Malformation Masquerading as a Bladder Tumor. A Case Report.

Anal Quant Cytopathol Histpathol 2015 Oct;37(5):322-5

Background: Arteriovenous malformation (AVM) of the urinary bladder is an extremely rare benign vascular lesion. The clinical significance of bladder AVM lies in its presentation with painless hematuria and a hyperemic sessile bladder wall mass.

Case Report: A 47-year-old man presented with irritative symptoms and hematuria. Read More

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October 2015
53 Reads

Effects of Nicotine on the Submandibular Gland in Rats.

Anal Quant Cytopathol Histpathol 2015 Oct;37(5):317-21

Objective: To evaluate the histopathologic and immunohistochemical effects of systemic use of nicotine on the submandibular glands.

Study Design: We investigated the effects of nicotine on apoptosis and angiogenesis. Twenty adult Sprague-Dawley rats were divided into 2 groups: nicotine (n = 10) and controls (n = 10). Read More

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October 2015
9 Reads

Effects of Potentilla fulgens as a Prophylactic Agent for Ischemia/Reperfusion Injury in the Rat Ovary.

Anal Quant Cytopathol Histpathol 2015 Oct;37(5):310-6

Objective: To investigate the effects of Potentilla fulgens as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary.

Study Design: A total of 32 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia + reperfusion, and (IV) IR + Potentilla fulgens. In groups I and II, ovary torsion was not performed and no drug was administered. Read More

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October 2015
22 Reads

High Proportion of Nuclear Phenotype Identifies Aggressive Cutaneous Squamous Cell Carcinoma.

Anal Quant Cytopathol Histpathol 2015 Oct;37(5):302-9

Objective: To develop a quantitative histopathology algorithm to predict which patients with cutaneous squamous cell carcinoma (cSCC) were likely to experience recurrence or metastases.

Study Design: This retrospective study of cSCC lesions compared patients with aggressive disease (n = 40) and those with nonaggressive disease (n = 35). Based on a previous study using nuclear karyometry, we determined that aggressive lesions had a high proportion of a specific nuclear phenotype. Read More

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October 2015
8 Reads

Serum Osteopontin Levels Correlate with Clinical and Pathological Features in Non-Small Cell Lung Cancer.

Anal Quant Cytopathol Histpathol 2015 Oct;37(5):295-301

Objective: A metaanalysis was performed to investigate the association between serum osteopontin (OPN) levels and the clinical pathological features in non-small cell lung cancer (NSCLC) patients.

Study Design: A systematic literature search was performed to identify relevant studies published prior to September 2014 using PubMed and China National Knowledge Infrastructure databases. Data extracted from the selected studies were analyzed using statistical software. Read More

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October 2015
9 Reads

Trophoblast Cell Proliferation and Apoptosis in Placental Development During Early Gestation Period in Rats.

Anal Quant Cytopathol Histpathol 2015 Oct;37(5):286-94

Objective: To show apoptotic and mitotic activities in differentiation and proliferation of the trophoblast through the techniques of immunohistochemistry and terminal deoxynucleotidyl transferase-mediated deoxy-uridine triphosphate-biotin nick end labeling (TUNEL), apart from achieving a morphological examination of placental development during early gestation in rats.

Study Design: Animals were sacrificed on days 7, 9, 11, and 13 of pregnancy. The samples removed from those rats were processed for purposes of microscopic analysis. Read More

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October 2015
2 Reads

Lymph Node Metastasis Status in Breast Carcinoma Can Be Predicted via Image Analysis of Tumor Histology.

Anal Quant Cytopathol Histpathol 2015 Oct;37(5):273-85

Objective: To develop a method whereby axillary lymph node (ALN) metastasis can be predicted without ALN dissection, via computational image analysis of routinely acquired tumor histology.

Study Design: We employed digital image processing to stratify patients based on the histological attributes of the primary tumor. We extracted image features that capture the nuclear and architectural properties of the specimen. Read More

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October 2015
2 Reads

Mucinous Adenocarcinoma of the Male Urethra: A Report of Two Cases.

Anal Quant Cytopathol Histpathol 2015 Aug;37(4):267-72

Background: Primary malignancies arising in the urethra are rare and, contrary to the other genitourinary malignancies, are more common in female patients. The pathologic diagnosis of primary adenocarcinoma can be challenging due to its rarity and overlapping features with other primary and secondary malignancies. There is no specific immunoprofile to define these adenocarcinomas, but available markers may allow comparison with common secondary tumors. Read More

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August 2015
5 Reads

Effect of Tunicamycin on Glycosaminoglycans and Laminins in Embryonic and Postnatal Thymic Tissues.

Anal Quant Cytopathol Histpathol 2015 Aug;37(4):252-66

Objective: To compare histological and molecular alterations in the embryonic and neonatal thymi following exposure to tunicamycin.

Study Design: Mouse embryos at gestational days 17 (n = 7) and 18 (n = 7) and newborn animals at post-natal days 1 (n = 5) and 3 (n = 5) were divided into two groups: control and tunicamycin-treated. Combined Alcian blue and Periodic acid-Schiff sequences immunohistochemistry and immunoblotting were performed to determine glycosaminoglycan (GAG) accumulation and laminin expression in control and tunicamycin-treated embryonic and postnatal thymi. Read More

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August 2015
3 Reads

Effect of Resveratrol on Leptin and Sirtuin 2 Expression in the Kidneys in Streptozotocin-induced Diabetic Rats.

Anal Quant Cytopathol Histpathol 2015 Aug;37(4):243-51

Objective: To investigate the effect of resveratrol (RSV) on the histopathology and leptin and sirtuin 2 expression levels of the kidneys in streptozotocin (STZ)-induced diabetic rats.

Study Design: The study was carried out with 33 young, healthy, female Wistar Albino rats. STZ was given (50 mg/kg, intraperitoneal, single dose) to the rats to induce and constitute a diabetes model. Read More

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August 2015
3 Reads

Expression Pattern of Calcitonin Gene-related Peptide-like Immunoreactivity in the Duck Thymus During Embryonic and Postembryonic Development.

Anal Quant Cytopathol Histpathol 2015 Aug;37(4):235-42

Objective: To study the expression pattern of calcitonin gene-related peptide (CGRP)-like immunoreactivity (-ir) in the duck thymus during the embryonic and postembryonic development.

Study Design: Studies were carried out on Tianfu ducks on 12, 14, 16, 18, 20, 22, 24, and 26 days of age prehatching, and at 0 (hatching), 1, 3, 5, 8, 14, 17, 20, 26, 29, and 32 weeks of age posthatching using high-sensitivity immunocytochemistry.

Results: CGRP-ir was detected in the neuron-like cells, the lymphocytes, the vascular smooth muscle cells, as well as the reticular epithelial cells of Hassall's corpuscle and diffuse forms of Hassall's corpuscle. Read More

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August 2015
5 Reads

Light and Transmission Electron Microscopic Studies on Subacute Toxicity of Bisphenol A on the Rat Ovary.

Authors:
Salina Y Saddick

Anal Quant Cytopathol Histpathol 2015 Aug;37(4):227-34

Objective: To investigate subacute toxicity of Bisphenol A (BPA) in adult rat ovaries using gastric intubation daily for 4 weeks by light and transmission electron microscopy.

Study Design: Fifteen rats were included in the study and divided into 2 groups: 12 rats were used for BPA administration (600 mg/kg body weight), and 3 rats received only vehicle and served as controls. The ovaries of both treated and control rats were taken at 1, 2, 3, and 4 weeks postadministration, fixed in 10% neutral buffered formalin, and processed for light microscopy. Read More

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August 2015
2 Reads

Evaluation of the Role of Granzyme B in Exuberant Scar Pathogenesis: An Immunohistochemical Study.

Anal Quant Cytopathol Histpathol 2015 Aug;37(4):221-6

Objective: To evaluate the possible role of Granzyme B (GzmB) in abnormal wound healing through its immunohistochemical expression in keloid and hypertrophic scars and to study the relationship of its expression with the clinicopathologic parameters of studied cases.

Study Design: Using immunohistochemical techniques, GzmB was analyzed in skin biopsies of 44 patients (30 cases with abnormal scars [21 with keloid and 9 with hypertrophic scars] and 14 age- and gender-matched cases with surgical scars as a control group).

Results: GzmB was expressed in keratinocytes in 28. Read More

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August 2015
51 Reads

Upregulation of the L-type Calcium Channel in Renin-Positive Smooth Muscle Cells of Arterioles in the Kidneys of Rats with Streptozotocin-Induced Diabetes.

Anal Quant Cytopathol Histpathol 2015 Aug;37(4):214-20

Objective: To estimate the number of L-type calcium (Ca2+) channels in the afferent and efferent arteriolar renin-positive and renin-negative smooth muscle cells and endothelial cells of the kidney arterioles in order to seek a relationship between the cell functions and the number of ion channels in the cell membranes.

Study Design: In diabetes the main source of renin/prorenin is the tubules, while the renin granulation of the afferent arterioles is increased relative to the normal. The release of renin is related to the Ca2+ levels of the intracellular and extracellular spaces of the afferent arterioles. Read More

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Analytical and Quantitative Cytopathology and Histopathology: Three Years Later.

Anal Quant Cytopathol Histpathol 2015 Aug;37(4):211-3

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Micronodular Thymoma with Lymphoid Stroma Diagnosed with Core Needle Biopsy. A Case Report.

Anal Quant Cytopathol Histpathol 2015 Jun;37(3):206-10

Background: Micronodular thymoma with lymphoid stroma (MNT) is an unusual type of thymoma characterized by multiple, discrete, small epithelial nodules with cytological features of type A thymoma that are separated by abundant reactive lymphoid tissue. Diagnosis of MNT usually relies on surgical specimens and could be challenging with needle biopsies. We present a case diagnosed via a core needle biopsy since the patient was unfit for and refused surgery. Read More

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June 2015
7 Reads

Mixed Epithelial and Stromal Tumor of the Kidney with Sarcomatous Transformation Metastatic to the Lung. A Case Report.

Anal Quant Cytopathol Histpathol 2015 Jun;37(3):199-205

Background: Malignant transformation of mixed epithelial and stromal tumor (MEST) of the kidney is a very rare entity. We report an unusual case with a review of the literature.

Case: A 25-year-old woman underwent surgery for an 8-cm biphasic renal tumor, which was diagnosed as MEST of the kidney. Read More

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June 2015
12 Reads

Biochemical and Histopathological Investigation of Resveratrol, Gliclazide, and Losartan Protective Effects on Renal Damage in a Diabetic Rat Model.

Anal Quant Cytopathol Histpathol 2015 Jun;37(3):187-98

Objective: To compare the protective effects of resveratrol, gliclazide, and losartan, at biochemical and histopathological levels, on the rat kidney with experimentally induced type 1 diabetes.

Study Design: A total of 35 adult male Wistar rats were divided into control, diabetic, diabetic gliclazide, diabetic resveratrol, and diabetic losartan groups. For biochemical analysis, based on one of the kidneys, superoxide dismutase, malondialdehyde, and catalase were used for measurement. Read More

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June 2015
67 Reads

Color Correction of Stained Tissue Section Images by Histogram Transfer According to Control Images.

Anal Quant Cytopathol Histpathol 2015 Jun;37(3):177-86

Objective: To present a color correction method by histogram transfer depending upon control tissue image (CTI) differences, and subsequently evaluate its performance.

Study Design: Images from colon and placenta sections stained by anti-CD34 were used as CTI and/ or sample tissue images (STIs). In total, 36 slides were stained: 1 according to standard procedure and 35 with some variation in the durations or dilutions used for the staining process. Read More

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June 2015
8 Reads

Impairment and Regeneration of Gastric Mucosa After Irradiation in Mice.

Anal Quant Cytopathol Histpathol 2015 Jun;37(3):169-76

Objective: To understand the effects of γ-ray irradiation (IR) on the proliferation of gastric mucosal cells and to investigate the possible mechanisms that affect gastric mucosal cell proliferation.

Study Design: C57BL/6J mice were exposed to IR at various doses (4, 8, and 15 Gy). We measured the changes of gastric mucosal BrdU-positive cells and the expression of β-catenin protein in the isthmus of fundic glands at days 1, 3, and 5 after irradiation. Read More

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June 2015
3 Reads

Preprocessing with Photoshop Software on Microscopic Images of A549 Cells in Epithelial-Mesenchymal Transition.

Anal Quant Cytopathol Histpathol 2015 Jun;37(3):159-68

Objective: To establish a preprocessing method for cell morphometry in microscopic images of A549 cells in epithelial-mesenchymal transition (EMT).

Study Design: Adobe Photoshop CS2 (Adobe Systems, Inc.) was used for preprocessing the images. Read More

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June 2015
2 Reads

Cytological Analysis of Low-grade Squamous Intraepithelial Lesion with a Histodiagnosis of Cervical Intraepithelial Neoplasia 3 (Severe Dysplasia) Prospectively.

Anal Quant Cytopathol Histpathol 2015 Jun;37(3):153-8

Objective: To reanalyze the cytological features of the first cytological specimens of cervical intraepithelial neoplasia 3 (CIN3) (severe) cases that were initially cytodiagnosed as LSIL and followed up for up to 5 years.

Study Design: Among 14,556.patients in 2009, 236 (1. Read More

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June 2015
1 Read

Testicular Nodules Suspected for Malignancy. Does the Pathologist Make the Difference for Organ-Sparing Surgery? .

Anal Quant Cytopathol Histpathol 2015 Jun;37(3):147-52

Objective: To evaluate the factors that influence decision-making after frozen section examination (FSE) when a urologist sends a surgical specimen of a testicular nodule to a pathologist.

Study Design: We retrieved, from surgical and pathological files of our center from 2008 to 2014, the clinical information of 15 patients who underwent an explorative inguinal testicular surgery for an intratesticular nodule suspected for malignancy and managed with intention of testicular-sparing surgery. We identify the factors that influenced the correlation between outcome of the FSE and final histopathological report. Read More

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June 2015
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