227,274 results match your criteria Analytical and bioanalytical chemistry[Journal]
J Pharm Biomed Anal 2018 Nov 28;165:94-100. Epub 2018 Nov 28.
Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, State Key Laboratory Base of Eco-Chemical Engineering, Key Laboratory of Rubber-Plastics of Ministry of Education/Shandong Provincial Key Laboratory of Rubber Plastics, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:
MoS, a typical transition metal disulfide, is widely used in the photoelectrochemical (PEC) sensor construction. In general, MoS based PEC sensor are "signal-on" strategies. Surprisingly, we discovered that the PEC response of MoS was quenched by methionine greatly. Read More
J Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 7;1104:196-204. Epub 2018 Nov 7.
Department of Chemistry, Semnan University, Semnan 35195-363, Iran.
For the first time, three phase hollow fiber liquid phase microextraction using an influential, and green middle phase comprised a new relatively-hydrophobic deep eutectic solvent (three-phase HF-LPME-DES) was developed for trace analyses of antiarrhythmic drugs in biological and environmental samples. The extraction solvent was easily synthesized by mixing the green and cheap raw materials, namely choline chloride and 1-phenylethanol (ChCl: Ph-ETOH), in the ambient temperature. Good compatibility to pores of hollow-fiber, high ability for extraction of ionizable organic compounds with no need to any carrier agents, and easy availability in the laboratory environment turned this new proposed deep eutectic intermediate to a worthy generation of the supported liquid membrane (SLM). Read More
Eur J Pharm Sci 2018 Dec 3. Epub 2018 Dec 3.
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary. Electronic address:
A new renaissance started in the research and application of cyclodextrins a few years ago. 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is used in the formulation of drugs and recently orphan designation was granted for the treatment of Niemann-Pick disease, type C. HPBCD is considered to be safe, but the exact mechanism of action and side effects are not completely explained. Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
University of Sfax Tunisia, Faculty of Sciences, Department of Life Sciences, Laboratory of Biodiversity and Aquatic Ecosystems, Ecology and Planktonology, Unit UR 11 ES 72/Street of Soukra Km 3,5, B.P. 1171, CP 3000, Tunisia.
The nano-encapsulation of Periploca angustifolia phenolic extract using the macrocyclic carbohydrate polymers (β‑cyclodextrins) is a most approach compared with other encapsulation methods. In this work, the β‑Cyclodextrins-PAE complex stability has been evaluated by advanced analytical methods and techniques including HPLC, FTIR and XRD. The results showed that CdCl treatment caused a significant decrease in cell viability. Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Computation and Simulation Unit (Analytical and Environmental Science Division and Centralized Instrument Facility), CSIR-Central Salt & Marine Chemicals Research Institute, India; Academy of Scientific and Innovative Research, CSIR-CSMCRI, Bhavnagar, Gujarat 364 002, India. Electronic address:
Search for inhibitors to stabilize the telomeric G-quadruplex in order to deter telomerase activity is an active area of research. Inhibitors play an important role to initiate the tumor cell mortalization process. This work reports for the first time of acridine derivative with four membered ammonium rings at the side chain to surpass the binding ability against BRACO-19 with G-quadruplex-DNA. Read More
J Theor Biol 2018 Dec 3. Epub 2018 Dec 3.
Ruppin Academic Center, School of Engineering, Unit of Engineering & Management, Emek Hefer 40250, Israel. Electronic address:
The classical, monomorphic, evolutionary games analyze competition among phenotypes while implicitly assuming monomorphic transmission of phenotypic attributes to successive generations. The recently formulated polymorphic evolutionary game theory (PEGT), which adds the underlying genetics and sexual reproduction to evolutionary games, has the potential to revolutionize game theoretical modeling of co-evolutionary processes. In this paper, I apply PEGT methods to the analysis of animal conflicts ࣧ the oldest, and one of the best-developed areas of evolutionary game modeling. Read More
Acta Ortop Mex 2018 May-Jun;32(3):145-156
Servicio de Cirugía Ortopédica y Traumatología. Hospital Clínico Universitario de Valencia. Valencia, España.
Background: To quantify the morphological changes in the surface of the back of adolescents with idiopathic scoliosis as a result of treatment with braces and to correlate them with radiographic changes.
Material And Methods: An analytical, cohort, prospective study on a sample of 31 adolescents with idiopathic scoliosis. We divided them into two groups: eleven treated with braces and twenty without them. Read More
Angew Chem Int Ed Engl 2018 Dec 6. Epub 2018 Dec 6.
University of Alcalá, Analytical Chemistry and Chem. Ing., Ctra Madrid-Barcelona km 33,600, 28871, Alcalá de Henares, SPAIN.
CdS quantum dots/C60 tubular micromotors with chemical/multi-light-controlled propulsion and "on-the-fly" acceleration capabilities are described. "In-situ" growth of CdS quantum dots on the outer fullerene layer impart them with light-responsive properties in connection to inner Pt, Pd or MnO2 layers. This is the first time that visible-light is used to drive bubble propelled tubular micromotors. Read More
PLoS One 2018 6;13(12):e0208281. Epub 2018 Dec 6.
The Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, Mississippi, United States of America.
Microbiome studies focused on ecologically relevant vertebrate models like reptiles have been limited. Because of their relatively small home range, fast maturation, and high fecundity, lizards are an excellent reptilian terrestrial indicator species. For this study we used the green anole, Anolis carolinensis, to assess the impact of military relevant contaminants on fecal microbiome composition. Read More
PLoS One 2018 6;13(12):e0208354. Epub 2018 Dec 6.
Department of Health Statistics, Fourth Military Medical University, Xi'an, Shannxi, China.
Analytical similarity assessment of critical quality attributes (CQAs) serves as a foundation for the development of biosimilar products and facilitates an abbreviated subsequent clinical evaluation. In this study, we establish a statistical evaluation roadmap with statistical approaches for some selected CQAs from Tier 1, because they are most relevant to clinical outcomes and require the most rigorous statistical methods. In the roadmap, we incorporate 3 methods-ranking and tier assignment of quality attributes, the equivalence test, and the Mann-Whitney test for equivalence-that are important to determine analytical similarity between the reference and biosimilar products. Read More
PLoS One 2018 6;13(12):e0208389. Epub 2018 Dec 6.
Groningen Research Institute of Pharmacy, unit PharmacoTherapy, -Epidemiology & -Economics, University of Groningen, Groningen, The Netherlands.
Prescription sequence symmetry analysis (PSSA), a case-only design introduced in 1996, has been increasingly used to identify unintentional drug effects, and has potential applications as a hypothesis-testing and a hypothesis-generating method, due to its easy application and effective control of time-invariant confounders. The aim of this study is to systematically compare effect estimates from the PSSA to effect estimates from conventional observational parallel group study designs, to assess the validity and constraints of the PSSA study design. We reviewed the MEDLINE, EMBASE, and Web of Science databases until February 2016 to identify studies that compared PSSA to a parallel group design. Read More
Chemphyschem 2018 Dec 6. Epub 2018 Dec 6.
Centre National de la Recherche Scientifique, Bâtiment 27, 1, avenue de la Terrasse, 91198, Gif-sur-Yvette, FRANCE.
The analysis of complex mixtures of dissolved molecules is a major challenge, especially for systems that gradually evolve, e.g., in the course of a chemical reaction or in the case of chemical instability. Read More
Med Phys 2018 Dec 6. Epub 2018 Dec 6.
Department of Radiation Oncology, University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
Purpose: The goal of this work is to provide a large and consistent set of data for detector specific output correction factors, , for small static fields for seven solid state detectors and to determine field output factors, , using EBT3 radiochromic films and W1 plastic scintillator as reference detectors on two different linear accelerators and four megavoltage photon beams. Consistent measurement conditions and recommendations given in the International Code of PracticeTRS-483 for small field dosimetry were followed throughout the study.
Methods: were determined on two linacs, Elekta Versa HD and Varian TrueBeam, for 6 and 10 MV beams with and without flattening filter and for nine fields ranging from 0. Read More
Toxicol Sci 2018 Dec 5. Epub 2018 Dec 5.
BIOBIDE, Donostia - San Sebastián, Gipuzkoa, Spain.
The standard methods for toxicity testing using rodent models cannot keep pace with the increasing number of chemicals in our environment due to time and resource limitations. Hence, there is an unmet need for fast, sensitive and cost-effective alternate models to reliably predict toxicity. As part of Tox21 Phase III's effort, a 90-compound library was created and made available to researchers to screen for neurotoxicants using novel technology and models. Read More
Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.
Analytical Services International (ASI), St George's-University of London, Cranmer Terrace, London SW17 0RE, UK.
Background: Measurement of flecainide is useful to optimize dosage and minimize risks of toxicity. Further, there is a need for urgent sample analysis when flecainide is used in transplacental therapy for fetal tachycardia. To this end, we have developed and validated a rapid assay for the measurement of flecainide in human plasma or serum, using a small sample volume (50 µL). Read More
J Atten Disord 2018 Dec 6:1087054718815572. Epub 2018 Dec 6.
4 The Hebrew University of Jerusalem, Israel.
Objective: ADHD is related to decision-making deficits in real-life (e.g., substance abuse) and on experimental tasks (increased preference for risky options). Read More
Analyst 2018 Dec 6. Epub 2018 Dec 6.
Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, P. R. China. and College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, P. R. China.
A simple protocol for in situ growth of Cu2-xSe nanoparticles on graphene oxide hybrids (Cu2-xSe/rGO) acting as an efficient nanozyme is developed and thus a sensitive visual detection method of cancer cells is proposed. The Cu2-xSe/rGO heterogeneous nanomaterials have been proven to exhibit high peroxidase-like activity to catalyze the reaction of the peroxidase substrate in the presence of hydrogen peroxide. Herein, we used Cu2-xSe/rGO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells and a total of 63 cancer cells (MCF-7) can be distinguished by naked-eye observation. Read More
J Appl Microbiol 2018 Dec 5. Epub 2018 Dec 5.
Department of Analytical Biochemistry, Faculty of Biology and Agriculture, University of Rzeszów, 4 Zelwerowicza Street, 35-601, Rzeszów, Poland.
Aims: The aim of the study was to check whether two flavanols [(-)-epigallocatechin gallate and (+)-catechin] can ameliorate oxidative stress accompanying and contributing to the lethal effects of heating (50°C) and freezing-thawing on the yeast Saccharomyces cerevisiae.
Methods And Results: The flavanols studied increased yeast survival during heating and freezing-thawing, estimated by the colony forming assay. They improved also such indices of oxidative stress as increased production of reactive oxygen species, decrease of total antioxidant activity of yeast cell extracts and increase in the level of protein carbonyls. Read More
EJNMMI Phys 2018 Dec 5;5(1):34. Epub 2018 Dec 5.
Biomedical Imaging Science Department, School of Medicine, University of Leeds, Leeds, West Yorkshire, UK.
Background: Positron emission tomography (PET) imaging has a wide applicability in oncology, cardiology and neurology. However, a major drawback when imaging very active regions such as the bladder is the spill-in effect, leading to inaccurate quantification and obscured visualisation of nearby lesions. Therefore, this study aims at investigating and correcting for the spill-in effect from high-activity regions to the surroundings as a function of activity in the hot region, lesion size and location, system resolution and application of post-filtering using a recently proposed background correction technique. Read More
J Neurovirol 2018 Dec 5. Epub 2018 Dec 5.
Department of Psychiatry, 1E.1 WC Mackenzie Health Sciences Centre, University of Alberta, Edmonton, AB, T6G 2R7, Canada.
The measurement and determinants of HIV-associated neurocognitive disorders (HAND) are under intense debate. We used latent profile analysis (LPA) and machine learning to define neurocognitive performance profiles and identify their associated risk factors in HIV patients receiving antiretroviral therapy (ART). Neurocognitive performance was assessed by a multidomain neuropsychological test battery. Read More
Anal Bioanal Chem 2018 Dec 6. Epub 2018 Dec 6.
Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Capillary electrophoresis (CE) is excellent at separating all the ions in a sample but is rarely used as a result of its detection issue and easy loss of very fast ions by common one-end injection methods. Herein we propose a newly developed method aimed at simultaneous determination of positive and negative ions with a home-made CE device, featuring bi-end injection and contactless conductivity detection at the middle. By simply using 2. Read More
Methods Mol Biol 2019 ;1888:273-309
Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.
Drugs modulate disease states through their actions on targets in the body. Determining these targets aids the focused development of new treatments, and helps to better characterize those already employed. One means of accomplishing this is through the deployment of in silico methodologies, harnessing computational analytical and predictive power to produce educated hypotheses for experimental verification. Read More
Mikrochim Acta 2018 Dec 5;186(1). Epub 2018 Dec 5.
Key laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, China.
A fluorometric method is described for the determination of the activity of the enzyme T4 polynucleotide kinase phosphatase (T4 PNKP). A short 3'-terminus phosphorylated DNA strand is hybridized with a long DNA strand to produce a partially double-stranded DNA (dsDNA) substrate. On addition of T4 PNKP, the substrate is dephosphorylated to generate the long dsDNA, and then the long dsDNA acted as a template for synthesizing copper nanoclusters (CuNCs). Read More
Soft Matter 2018 Dec 6. Epub 2018 Dec 6.
Department for Physics and Astronomy, Lägerhyddsvägen 1, 752 37 Uppsala, Sweden.
Entangled polymers are deformed by a strong shear flow. The shape of the polymer, called the form factor, is measured by small angle neutron scattering. However, the real-space molecular structure is not directly available from the reciprocal-space data, due to the phase problem. Read More
MethodsX 2018 17;5:1503-1507. Epub 2018 Nov 17.
Alma Mater Studiorum - University of Bologna, Department of Veterinary Medical Sciences, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia, BO, Italy.
Ivermectin is an endectocide belonging to the macrocyclic lactone class, commonly used in dogs as a heartworm preventative and for the treatment of several external and internal parasite infections. Among the analytical methods for ivermectin determination in plasma available in literature, many require a laborious clean-up step on SPE cartridge, and use fluorescence detection instead of the more reliable mass spectrometry. In the context of a project aimed at its pharmacokinetic evaluation in this species, a liquid chromatography-tandem mass spectrometry method for the determination of ivermectin in dog plasma was developed and validated, using blank plasma provided by a local canine blood transfusion service. Read More
IEEE J Transl Eng Health Med 2018 18;6:2101009. Epub 2018 Oct 18.
Industrial Design DepartmentEindhoven University of Technology5612AZEindhovenThe Netherlands.
The objective is to evaluate to which extent that a garment equipped with sensors that can support posture monitoring can be used in upper extremity rehabilitation training of stroke patients. Seventeen stroke survivors (mean age: 55 years old, SD =13.5) were recruited in three hospitals in Shanghai. Read More
Clin Proteomics 2018 1;15:39. Epub 2018 Dec 1.
1Ryerson Analytical Biochemistry Laboratory (RABL), Department of Chemistry and Biology, Faculty of Science, Ryerson University, 350 Victoria St, Toronto, ON Canada.
Background: It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma using LC-ESI-MS/MS to identify, with a linear quadrupole ion trap to identify, quantify and compare the statistical distributions of peptides cleaved ex vivo from plasma samples from different clinical populations.
Methods: A systematic method for the organic fractionation of plasma peptides was applied to identify and quantify the endogenous tryptic peptides from human plasma from multiple institutions by C18 HPLC followed nano electrospray ionization and tandem mass spectrometry (LC-ESI-MS/MS) with a linear quadrupole ion trap. The endogenous tryptic peptides, or tryptic phospho peptides (i. Read More
J Oncol Pharm Pract 2018 Dec 5:1078155218816779. Epub 2018 Dec 5.
1 Analytical chemistry laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Introduction: A few years after the discovery and development of anti-infectives, this therapeutic feat gave way to bacterial resistance because of the overconsumption of antibiotics, most often with unjustified prescriptions. The objective was to evaluate the compliance of the prescription of antibiotherapy in the pediatric onco-hematology unit of Rabat Children's Hospital and to determine the drug interactions.
Material And Methods: This is a retrospective study of anti-infectives prescriptions in pediatric onco-hematology. Read More
Crit Rev Anal Chem 2018 Dec 5:1-8. Epub 2018 Dec 5.
a School of Pharmaceutical Sciences , São Paulo State University (UNESP) , Araraquara , São Paulo , Brazil.
Infections are the second leading cause of global morbidity and mortality, therefore it is highly important to study the antimicrobial agents such as cephalosporins. Cephalothin, an antimicrobial agent that belongs to the class of cephalosporins, has bactericidal activity and it is widely used in the Brazilian health system. In literature, some analytical methods are found for the identification and quantification of this drug, which are essential for its quality control, which ensures maintaining the product characteristics, therapeutic efficacy and patient's safety. Read More
Mar Drugs 2018 Dec 4;16(12). Epub 2018 Dec 4.
Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University Jena, Lessingstr. 8, D-07743 Jena, Germany.
Algicidal bacteria can lyse microalgal blooms and trigger shifts within plankton communities. Resistant algal species can escape lysis, and have the opportunity to dominate the phytoplankton after a bacterial infection. Despite their important function in ecosystem regulation, little is known about mechanisms of resistance. Read More
Mar Drugs 2018 Dec 4;16(12). Epub 2018 Dec 4.
Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico (IST), Universidade de Lisboa, 1049-001 Lisbon, Portugal.
Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved. This review inventories the natural products so-far described for octocoral-derived bacteria and fungi, uncovering a true chemical arsenal of terpenes, steroids, alkaloids, and polyketides with antibacterial, antifungal, antiviral, antifouling, anticancer, anti-inflammatory, and antimalarial activities of enormous potential for blue growth. Read More
Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.
Orthopaedics and Rehabilitation Clinic, Medical University Lublin, Chodźki 4a, Lublin 20-093, Poland.
Abiotic stress, including metal excess, can modify plant metabolism. Here we investigated the influence of long-term strontium exposure (12 weeks, 0.5⁻4. Read More
Solid State Nucl Magn Reson 2018 Nov 22;97:17-24. Epub 2018 Nov 22.
Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Banacha 1, 02-093 Warsaw, Poland.
Piracetam, a popular nootropic drug, widely used in the treatment of age-associated mental decline and disorders of the nervous system such as Alzheimer's disease and dementia exists under normal pressure in three polymorphic forms (P1, P2 and P3) of different stability. In this work the relative stability of piracetam polymorphs depending on the temperature was studied using the ssNMR spectroscopy combined with ab initio DFT calculations. The ssNMR spectroscopy enabled the analysis of polymorphic phase transition in the case of pure active substance as well as polymorphic form identification in the analysis of the commercial solid dosage formulations. Read More
Brain Res Bull 2018 Nov 30. Epub 2018 Nov 30.
Department of Analytical Biochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan. Electronic address:
Methylglyoxal (MG) is an α-dicarbonyl compound that is naturally produced in vivo through glucose metabolism. In general, MG is metabolized by the glyoxalase 1(GLO1)/GLO2 system and aldose reductase (AR); however, excessive MG can react with proteins and nucleic acids to induce the accumulation of advanced glycation end products (AGEs). Recently, the accumulation of AGEs in the brain has been presumed to be related to neurodegenerative diseases such as Parkinson's and Alzheimer's disease, respectively. Read More
Free Radic Biol Med 2018 Nov 30. Epub 2018 Nov 30.
Department of Pharmaceutical Science, University of Perugia, Perugia, Italy. Electronic address:
Lipid peroxidation is one of the earliest pathogenic events of non-alcoholic fatty liver disease (NAFLD). In this context, an increased oxidation of the lipoperoxyl radical scavenger α-tocopherol (α-TOH) should occur already in the subclinical phases of the disease to compensate for the increase oxidation of the lipid excess of liver and possibly of other tissues. However, this assumption remains unsupported by direct analytical evidence. Read More
Exp Gerontol 2018 Nov 30. Epub 2018 Nov 30.
California Pacific Medical Center Research Institute, San Francisco, CA, United States of America.
Background: We provide the first examination of mitochondrial DNA (mtDNA) variants and pulmonary function in older persons.
Methods: Cross-sectional associations between mtDNA variants and pulmonary function were evaluated as a combined p-values meta-analysis, using data from two independent cohorts of older persons. The latter included white and black participants, aged ≥70 years, from the Lifestyle Interventions and Independence for Elders study (LIFE) (N = 1247) and the Health, Aging and Body Composition study (Health ABC) (N = 731), respectively. Read More
Clin Biochem 2018 Nov 30. Epub 2018 Nov 30.
Clinical Pathology Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.
Clin Biochem 2018 Nov 30. Epub 2018 Nov 30.
Discipline of Laboratory Medicine, Eastern Health Authority, Australia; Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Dr., St. John's, NL, Canada.
Objectives: This study investigated the analytical performance of glucose meters while in use for 1.5 years in a hospital setting. The effect of user competency, strip stability and strip lot number variation on the performance of blood glucose meters was investigated. Read More
Anal Chem 2018 Dec 3. Epub 2018 Dec 3.
Ion motion in Trapped Ion Mobility Spectrometers (TIMS) and Inverted Drift Tubes (IDT) has been investigated. The 2D axi-symmetric analytical solution to the Nernst-Planck equation for constant gas flows and opposed linearly increasing fields is presented for the first time and is used to study the dynamics of ion distributions in the ramp region. It is shown that axial diffusion confinement is possible and that broad packets of ions injected initially into the system can be contracted. Read More
PLoS One 2018 3;13(12):e0208182. Epub 2018 Dec 3.
Department of Biological Sciences, University of New Brunswick, Saint John, New Brunswick.
Freshwater fish populations are rapidly declining globally due to the impacts of rapid climate change and existing non-climatic anthropogenic stressors. In response to these drivers, freshwater fishes are responding by shifting their distribution range, altering the timing of migration and spawning and through demographic processes. By 2050, the mean daily air temperature is predicted to increase by 2 to 3 degrees C in insular Newfoundland and by 3 to 4 degrees C in Labrador. Read More
J Vis Exp 2018 Nov 17(141). Epub 2018 Nov 17.
Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine; Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine; Vascular Biology Institute, University of Miami Leonard M. Miller School of Medicine; Peggy and Harold Katz Family Drug Discovery Center, University of Miami Leonard M. Miller School of Medicine;
The regulation of LDL cholesterol uptake through LDLR-mediated endocytosis is an important area of study in various major pathologies including metabolic disorder, cardiovascular disease, and kidney disease. Currently, there is no available method to assess LDL uptake while simultaneously monitoring for health of the cells. The current study presents a protocol, using a live cell imaging analysis system, to acquire serial measurements of LDL influx with concurrent monitoring for cell health. Read More
Crit Care Med 2018 Nov 30. Epub 2018 Nov 30.
Department of Anesthesiology, University Medical Center Göttingen, Göttingen, Germany.
Objectives: The detection of microbial volatile organic compounds or host response markers in the exhaled gas could give an earlier diagnosis of ventilator-associated pneumonia. Gas chromatography-ion mobility spectrometry enables noninvasive, rapid, and sensitive analysis of exhaled gas. Using a rabbit model of ventilator-associated pneumonia we determined if gas chromatography-ion mobility spectrometry is able to detect 1) ventilator-associated pneumonia specific changes and 2) bacterial species-specific changes in the exhaled gas. Read More
J Public Health Manag Pract 2019 Jan/Feb;25 Suppl 1, Lead Poisoning Prevention:S23-S30
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
Context: The Lead and Multielement Proficiency (LAMP) program is an external quality assurance program promoting high-quality blood-lead measurements.
Objectives: To investigate the ability of US laboratories, participating in the Centers for Disease Control and Prevention (CDC) LAMP program to accurately measure blood-lead levels (BLL) 0.70 to 47. Read More
J Neural Eng 2018 Dec 3;16(1):016007. Epub 2018 Dec 3.
Department of Biomedical Engineering, Duke University, Room 1427, Fitzpatrick CIEMAS, 101 Science Drive, Campus Box 90281, Durham, NC 27708, United States of America.
Objective: Computational modeling is an important tool for developing and optimizing implantable neural stimulation devices, but requires accurate electrical and geometrical parameter values to improve predictive value. We quantified the effects of perineurial (resistive sheath around each fascicle) and endoneurial (within each fascicle) parameter values for modeling peripheral nerve stimulation.
Approach: We implemented 3D finite element models of compound peripheral nerves and cuff electrodes to quantify activation and block thresholds of model axons. Read More
IEEE Trans Cybern 2018 Nov 28. Epub 2018 Nov 28.
In this paper, spatial diffusions are introduced to fractional-order coupled networks and the problem of synchronization is investigated for fractional-order coupled neural networks with reaction-diffusion terms. First, a new fractional-order inequality is established based on the Caputo partial fractional derivative. To realize asymptotical synchronization, two types of adaptive coupling weights are considered, namely: 1) coupling weights only related to time and 2) coupling weights dependent on both time and space. Read More
J Microencapsul 2018 Dec 3:1-19. Epub 2018 Dec 3.
b Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Nowadays, since the core-shell gold-magnetite nanoparticles include the saturation magnetization (iron oxide) and plasmon surface (gold shell) properties, they have been considered in biological and biomedicine research areas. In the present work, multifunctional glutathione decorated gold-coated iron oxide nanoparticles (GSH-AuMNPs) were successfully synthesized and fully characterized. From the absorption peak at 525, the formation of the core-shell GSH-AuMNPs was confirmed. Read More
Langmuir 2018 Dec 3. Epub 2018 Dec 3.
Three-dimensional (3D) hierarchical wrinkles can be generated on pre-strained thermoplastic substrates by sequential cycles of skin layer growth followed by the release of pre-strain. However, no mechanics models have explained the formation of multi-generational nanostructures using this nanofabrication process. This paper describes an analytical model that can represent multi-scale wrinkles with arbitrary numbers of generations. Read More
Anal Chem 2018 Dec 3. Epub 2018 Dec 3.
Tuberculosis is currently the single most deadly infectious disease in the world and a public health priority as defined by WHO. Although the disease is in general curable, treatment success is hampered by the necessity of a long and side effect prone treatment. Low treatment efficiency may be partly due to the special growth states mycobacteria enter to avoid being killed by antibiotics and to persist longer within the host. Read More
ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.
Commercial bead-based assays are commonly built upon polystyrene particles. The polymeric carrier can be encoded with organic dyes and has ideal material properties for cytometric applications such as low density and high refractive index. However, functional groups are conventionally integrated during polymerization and subsequent modification is limited to the reactivity of those groups that have been introduced during the bead preparation step. Read More
Biotechnol Prog 2018 Dec 3. Epub 2018 Dec 3.
Process and Systems Engineering Centre (PROSYS), Department of Chemical and Biochemical Engineering, Technical University of Denmark, Søltofts Plads Building 229, DK-2800 Kgs. Lyngby, Denmark.
This article explores different opportunities to evaluate quality variation in raw materials from biological origin. Assessment of raw materials attributes is an important step in a bio-based production since fluctuations in quality are a major source of process disturbance. This can be due to a variety of biological, seasonal and supply scarcity reasons. Read More