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Anal Lett 2022 8;55(8):1269-1280. Epub 2021 Dec 8.

Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC, United States.

Thallium (Tl) can be released as a byproduct of smelting, mining, and other industries, causing human exposure. There are knowledge gaps on the toxicity of thallium compounds, so the National Toxicology Program is investigating the toxicity of thallium (I) sulfate in rodents. We developed and validated a method to quantitate Tl in rodent plasma and secondary matrices. Read More

Anal Lett 2022 11;55(9):1382-1397. Epub 2021 Dec 11.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC.

extract (GCE) is a popular botanical supplement used in weight loss products. Hydroxycitric acid (HCA) is the principal component in GCE. Due to lack of adequate toxicity data to assess the safe use of GCE, the National Toxicology Program is testing GCE in Hsd:Sprague Dawley® SD® rats following perinatal exposure and in adult B6C3F1/N mice. Read More

Anal Lett 2021 1;54(17):2777-2788. Epub 2021 Mar 1.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

Human exposure to vanadium (V) is anticipated because it is a drinking water contaminant. Due to limited data on soluble V salts, the National Toxicology Program is investigating the toxicity in rodents following drinking water exposure. Measurement of internal V dose allows for interpretation of toxicology data. Read More

Anal Lett 2019 ;53(3)

Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA.

The current analytical techniques for characterizing printing and graphic arts substrates, particularly those used to date and authenticate provenance, are destructive. This limits the amount of data that can be captured from an individual sample. For samples being evaluated in forensic and archeological investigations, any loss or degradation of the materials is undesirable. Read More

Anal Lett 2018 28;51(16):2612-2625. Epub 2018 Mar 28.

Department of Chemistry and Forensic Science, Albany State University, Albany, Georgia 31705.

Direct and efficient label-free voltammetric detection of Glutathione S-Transferase Pi 1 (GSTP1) hypermethylation is reported using a custom developed 16-channel Microelectrode Array chip. The microelectrode array chip is used in a dipstick configuration allowing detection of DNA hybridization in a solution volume of only 0.35 mL. Read More

Anal Lett 2017;50(3):567-579. Epub 2016 May 24.

Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284 USA.

The formation of protein carbonyls in the metal-catalyzed oxidation of human serum albumin (HSA) is characterized using a new analytical approach that involves tagging the modification site with multiple hydrazide reagents. Protein carbonyl formation at lysine and arginine residues was catalyzed with copper and iron ions, and the resulting oxidation patterns in HSA are contrasted. A total of 18 modification sites were identified with iron ion catalysis and 14 with copper ion catalysis. Read More

Anal Lett 2017;50(3):482-499. Epub 2016 May 24.

Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, USA.

A novel Cd(II)-imprinted polymer was prepared with chemical immobilization approach by using N-methacryloyl-L-histidine as a vinylated chelating agent for on-line solid phase extraction of Cd(II) for determination by inductively coupled plasma mass spectrometry. Cd(II)-monomer complex was synthesized and copolymerized via bulk polymerization method in the presence of ethyleneglycoldimethacrylate cross-linker. The resulting polymer was leached with 1. Read More

Anal Lett 2017 22;50(15):2447-2464. Epub 2017 Jun 22.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, MD EC-06, P.O. Box 12233, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA.

Zinc deficiency and excess can result in adverse health outcomes. There is conflicting evidence regarding whether excess or deficient zinc in the diet can contribute to carcinogenicity. The objective of this study was to characterize zinc carbonate basic for use as a source of dietary zinc in a rodent toxicity and carcinogenicity study investigating the effects of zinc deficiency and excess. Read More

Anal Lett 2017 12;50(15):2412-2425. Epub 2017 Sep 12.

Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL, USA.

is a human respiratory tract pathogen causing chronic bronchitis and atypical or "walking" pneumonia. The major surface protein P1 must form complexes with proteins P30 and P40/P90 in order to function in receptor binding and gliding motility, and variability in P1 and P40/P90 distinguishes the two major genotypes. Strains belonging to each genotype can be differentiated with high sensitivity and specificity by utilizing surface-enhanced Raman spectroscopy on silver nanorod arrays. Read More

Anal Lett 2016 Jul 22;49(10):1526-1536. Epub 2016 Feb 22.

Wuhan Research Institute of Materials Protection, State Key Laboratory of Special Surface Protection Materials and Application Technology , Wuhan , Hubei , China.

A method is reported for the determination of diphenylamine and butylated hydroxytoluene in mineral and synthetic oil. The procedure used differential pulse voltammetry with a glassy carbon electrode. This method was then used for determining these antioxidants in supporting electrolyte consisting of dilute sulfuric acid and sodium dodecyl sulfonate in ethanol. Read More

Anal Lett 2016 May 21;49(8):1272-1277. Epub 2016 Apr 21.

Department of Applied Sciences, Northumbria University , Newcastle upon Tyne , UK.

A novel method for the determination of benzoic acid has been employed to identify carboxypeptidase activities in clinically relevant pathogens. Benzoic acid was determined after chemical derivatization by gas chromatography-mass spectrometry (GC-MS). N-Benzoyl amino acid substrates were evaluated for the detection of carboxypeptidase activities in a number of clinical pathogens. Read More

Anal Lett 2016 Mar 8;49(5):711-722. Epub 2015 Jun 8.

Food Composition and Methods Development Lab, Beltsville Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland, 20705-2350, United States.

Two simple fingerprinting methods, flow-injection coupled to ultraviolet spectroscopy and proton nuclear magnetic resonance, were used for discriminating between and . Both methods were combined with partial least-squares discriminant analysis. In the flow-injection method, four data representations were evaluated: total ultraviolet absorbance chromatograms, averaged ultraviolet spectra, absorbance at 193, 205, 225, and 283 nm, and absorbance at 225 and 283 nm. Read More

Anal Lett 2015 May 31;48(7):1044-1069. Epub 2014 Dec 31.

Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA. ; Tel: 3152682394.

Neurotransmitters are important biological molecules that are essential to many neurophysiological processes including memory, cognition, and behavioral states. The development of analytical methodologies to accurately detect neurotransmitters is of great importance in neurological and biological research. Specifically designed microelectrodes or microbiosensors have demonstrated potential for rapid, real-time measurements with high spatial resolution. Read More

Anal Lett 2015;48(15):2482-2492. Epub 2015 May 5.

Department of Natural and Forensic Sciences, Albany State University, Albany, Georgia, USA.

The objective of this work was the development of reliable methods to determine 2,4-dinitrotoluene, a precursor to explosives. A complex between Fe(II) ion and 2,4-dinitrotoluene was formed in solution and characterized by ultraviolet-visible absorption spectroscopy using Job's plots and attenuated total reflection-Fourier transform infrared spectroscopy. Surface modification of glassy carbon electrodes were performed with iron nanoparticles via electrochemical reduction of iron(II). Read More

Anal Lett 2014 ;47(11):1835-1851

Food Composition and Methods Development Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD, US.

Traditional Chinese medicine has been widely used for the prevention and treatment of various diseases for thousands of years in China. Ultra-high performance liquid chromatography (UHPLC) is a relatively new technique offering new possibilities. This paper reviews recent developments in UHPLC in the separation and identification, fingerprinting, quantification, and metabolism of traditional Chinese medicine. Read More

Anal Lett 2014;47(1):58-76

Department of Chemistry & Biochemistry, Jackson State University, PO Box 17910, Jackson, MS 39217 USA.

A new chelating resin has been synthesized by immobilizing 4-(2-thiazolylazo) resorcinol (TAR) onto styrene divinlybenzene copolymer and examined for on-line solid phase extraction/preconcentration of Cd, Co, Cu, Ni, Pb and Zn in seawater and fish otoliths for determination by inductively plasma mass spectrometry (ICP-MS). A volume of 5.0 mL sample solution was loaded onto the mini column of TAR immobilized resin at 2. Read More

Anal Lett 2009 2;42(17):2729-2746. Epub 2009 Nov 2.

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

The validation of a method for the determination of total chromium in Fischer-344 rat feces by inductively coupled plasma optical emission spectrometry following a rapid, atmospheric-pressure microwave digestion is described. The performance of the method was evaluated over the concentration range of 5.00 to 200 μg Cr/g feces. Read More

Anal Lett 2008 Oct 2;41(15):2844-2859. Epub 2008 Dec 2.

College of Chemistry and Material Science, Shandong Agricultural University, Shandong, P. R. China.

A novel approach to prepare homogeneous PbS nanoparticles by phase-transfer method was developed. The preparatory conditions were studied in detail, and the nanoparticles were characterized by transmission electron microscopy (TEM) and UV-vis spectroscopy. Then a novel lead ion-selective electrode of polyvinyl chloride (PVC) membrane based on these lead sulfide nanoparticles was prepared, and the optimum ratio of components in the membrane was determined. Read More

Anal Lett 2007 Jan;40(7):1423-1433

University of California, Davis, California.

The application of quantum dots (QDs) as labels in immunoassay microarrays for the multiplex detection of 3-phenoxybenzoic acid (PBA) and atrazine-mercapturate (AM) has been demonstrated. PBA and AM are biomarkers of exposure to the pyrethroid insecticides and to the herbicide atrazine, respectively. Microarrays were fabricated by microcontact printing of the coating antigens in line patterns onto glass substrates. Read More

Anal Lett 1995 ;28(12):2149-59

Department of Chemistry, Southern University and A&M College, Baton Rouge, LA 70813, USA.

A piezoelectric crystal immunosensor has been developed for the detection and determination of cortisol. Cortisol antibody was layered onto the gold electrodes of a 10 MHz piezoelectric crystal which was pre-coated with either protein A or gluteraldehyde. Crystals pre-coated with protein A showed the best results with respect to stability and sensitivity. Read More