227,707 results match your criteria Analytical Chemistry Insights [Journal]
J Cancer Res Clin Oncol 2018 Dec 15. Epub 2018 Dec 15.
Department of Gastroenterology and Hepatology, Amsterdam UMC, Vrije Universiteit Amsterdam, AG&M Research Institute, Amsterdam, The Netherlands.
Introduction: The fecal volatolome, which is composed of fecal volatile organic compounds (VOCs), seems to hold potential as non-invasive biomarker for the detection of colorectal cancer (CRC) and its precursor lesions advanced adenomas (AA). The potential of the fecal volatolome has been subject of various studies using either chemical analytical or pattern-recognition techniques. The available literature on the potential of the fecal volatolome as CRC and AA biomarker was reviewed. Read More
Adv Ther 2018 Dec 15. Epub 2018 Dec 15.
Analytical Method Development Team, Samsung Bioepis Co., Ltd., Incheon, South Korea.
Introduction: Tumor necrosis factor (TNF-alpha) inhibitors, such as adalimumab, have shown success in treating autoimmune inflammatory diseases but are associated with substantial financial burdens to the healthcare system. Biosimilars, which are highly similar to biologic agents, offer the potential to reduce the financial burden of treatment. In the case of TNF-alpha inhibitors, they may also offer improved stability and enable prolonged use. Read More
Nephron 2018 Dec 14;141(2):1-5. Epub 2018 Dec 14.
Context: Human kidney organoids are complex structures resembling nephron arrays, which can be derived in a variety of ways. Whether all of these differentiation protocols produce qualitatively similar organoid cell types is not yet clear. Subject of Review: A comparative analysis of 2 organoid differentiation protocols is recently reported in Cell Stem Cell [Wu et al. Read More
J Colloid Interface Sci 2018 Dec 10;538:630-637. Epub 2018 Dec 10.
Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002 Jiangsu, PR China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 Jiangsu, PR China; Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210046 Jiangsu, PR China. Electronic address:
The development of effective targeted therapies for triple negative breast cancer (TNBC) remains a challenge. This targeted drug delivery system used a near-infrared fluorescence dye cyanine 5.5 (Cy5. Read More
J Chromatogr B Analyt Technol Biomed Life Sci 2018 Dec 6;1105:10-14. Epub 2018 Dec 6.
Biomedical Microscale Analytics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, the Netherlands. Electronic address:
Metabolomics studies using a small amount of cells may save time and money, while in some cases (e.g., profiling pathogenic cells in an early-stage tissue), only a small number of cells are accessible for analysis. Read More
Water Res 2018 Dec 6;150:392-402. Epub 2018 Dec 6.
Advanced Water Management Centre, The University of Queensland, St. Lucia, QLD, 4072, Australia. Electronic address:
Microbially induced concrete corrosion (MICC) is a major deterioration affecting sewers worldwide. MICC is not uniform on sewer inner walls and often occurs at hot spots such as crown and tidal regions, which are critical to determine sewer service life. Especially, concrete corrosion in tidal regions is complicated due to the fluctuation of wastewater levels and the hydraulic scouring effects. Read More
Environ Res 2018 Dec 6;170:1-6. Epub 2018 Dec 6.
Stockbridge School of Agriculture, University of Massachusetts Amherst, Amherst, MA 01003, United States.
In the present study, we investigated the antifungal effects of engineered nanomaterials (ENMs) against Podosphaera pannosa (P. pannosa), a fungal pathogen that causes powdery mildew on plants in the rose family. Four commercial ENMs, including multi-wall carbon nanotubes (MWCNTs), reduced graphene oxide (rGO), copper oxide (CuO) nanoparticles (NPs) and titanium dioxide (TiO) NPs, were used to prepare 50 or 200 mg/L NP suspensions in deionized water. Read More
J Environ Manage 2018 Dec 13;233:39-53. Epub 2018 Dec 13.
Irstea, UR OPAALE, 17 Avenue de Cucillé, CS 64427, F-35044, Rennes, France. Electronic address:
Hazardous and odorous gas emissions from composting and methanization plants are an issue of public concern. Odor and chemical monitoring are thus critical steps in providing suitable strategies for air pollution control at waste treatment units. In this study, 141 gas samples were extensively analyzed to characterize the odor and chemical emissions released upon the aerobic treatment of 10 raw substrates and five digestates. Read More
J Control Release 2018 Dec 13. Epub 2018 Dec 13.
Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy With the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha St., Warsaw 02-097, Poland. Electronic address:
Recently, growing interest in polymers (natural and synthetic) as drug carriers in controlled release formulations and drug targeting systems that may improve the efficacy of treatment and reduce the side effects of a drug therapy, has been observed. Special attention has been paid to improving the effectiveness of antibiotics, which constitute a very important, often life-saving group of drugs. In this paper, we review polymers as macromolecular carriers of fluoroquinolones, a group of antibiotics with a broad spectrum of activity. Read More
Anal Biochem 2018 Dec 13. Epub 2018 Dec 13.
Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. Electronic address:
Glycoproteins play a central role in diverse biological processes and are linked with many serious human diseases. In this paper we present a simple, reproducible and cost-effective analytical workflow that enables the reliable quantification of clinically relevant human plasma glycoproteins using label free microflow LC-MS/MS analysis. Plasma N-glycoproteins were selectively extracted via ConA Sepharose lectin affinity chromatography then separated into two fractions using reversed-phase solid phase extraction. Read More
Cell Syst 2018 Nov 30. Epub 2018 Nov 30.
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA. Electronic address:
Transcriptional and translational feedback loops in fungi and animals drive circadian rhythms in transcript levels that provide output from the clock, but post-transcriptional mechanisms also contribute. To determine the extent and underlying source of this regulation, we applied newly developed analytical tools to a long-duration, deeply sampled, circadian proteomics time course comprising half of the proteome. We found a quarter of expressed proteins are clock regulated, but >40% of these do not arise from clock-regulated transcripts, and our analysis predicts that these protein rhythms arise from oscillations in translational rates. Read More
Enferm Infecc Microbiol Clin 2018 Dec 12. Epub 2018 Dec 12.
Sección Epidemiología, Centro Salud Pública, Castelló, España; CIBER-ESP grupo 41; Departamento de Medicina, Facultad de Ciencias de la Salud, Universitat Jaume I (UJI), España. Electronic address:
Descriptive epidemiology of Yersinia enterocolitica infection in an area of Castellón (Spain) between 2006 and 2013 from Yersinia enterocolitica strains isolated in the area and confirmed by the Spanish national reference laboratory. There were a total of 144 cases. The estimated incidence was 9. Read More
J Chromatogr A 2018 Nov 24. Epub 2018 Nov 24.
Laboratory of Foodomics, Institute of Food Science Research, CIAL, CSIC, Nicolás Cabrera 9, 28049, Madrid, Spain. Electronic address:
In this work, a multi-analytical platform that allows obtaining and characterizing high-added value compounds from natural sources is presented, with a huge potential in traditional medicine, natural products characterization, functional foods, etc. Namely, the proposed multi-analytical platform is based on the combination of pressurized liquid extraction (PLE), liquid chromatography (LC) and gas chromatography quadrupole time-of-flight mass spectrometry GC-q-TOF-MS(/MS), in vitro assays and modelling tools for guiding extraction optimization. As case study, goldenberry or cape gooseberry fruit (Physalys peruviana L. Read More
J Safety Res 2018 Dec 27;67:1-15. Epub 2018 Sep 27.
College of Resources & Safety Engineering, China University of Mining & Technology(Beijing), Beijing, 100083, PR China. Electronic address:
Introduction: Currently, there is a lack of specific analytical tools for general aviation accidents (GAAs). This has led to loopholes in the prevention of GAAs.
Methods: A Swiss Cheese model for general aviation (SCM-GA) is proposed to identify the human and organizational factors involved in GAAs. Read More
Prostaglandins Leukot Essent Fatty Acids 2019 Jan 28;140:34-41. Epub 2018 Nov 28.
Comprehensive Heart Failure Center, University and University Hospital Würzburg, Germany; Dept. of Internal Medicine I - Cardiology, University Hospital Würzburg, Germany. Electronic address:
Background: Epidemiologic studies on the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in heart failure are scarce, while one large intervention trial demonstrated a modest benefit.
Methods: This is a secondary analysis from the Interdisciplinary Network Heart Failure (INH) program. Patients hospitalized for systolic heart failure were enrolled and followed for 36 months. Read More
Carbohydr Polym 2019 Feb 15;206:863-872. Epub 2018 Nov 15.
Natural Product Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India. Electronic address:
Cellulose extracted from the rhizomes of Alpinia nigra was utilized in the synthesis of cellulose acetate. Furthermore, the cellulose acetate reacted with organophillic montmorillonite to form a composite. All the products including cellulose, cellulose acetate and the composite were characterized with the help of standard analytical techniques. Read More
Carbohydr Polym 2019 Feb 15;206:504-510. Epub 2018 Nov 15.
School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address:
A simple and sensitive flow injection chemiluminescence (FI-CL) method has been developed for the determination of chondroitin sulfate (CS). The method is based on the sensitization effect of enzymatic products of CS on the luminol-HO system. Experimental parameters affecting FI-CL method such as concentrations of luminol, HO and NaOH and the standing time of luminol alkaline solution were optimized. Read More
Carbohydr Polym 2019 Feb 26;206:198-209. Epub 2018 Oct 26.
Johns Hopkins University, Sheridan Libraries and University Museums, Heritage Science for Conservation, 3400 North Charles Street, Baltimore, MD 21218, United States; Johns Hopkins University, Whiting School of Engineering, Department of Materials Science and Engineering, 3400 North Charles Street, Baltimore, MD 21218, United States. Electronic address:
Iron gall inks are known to be detrimental to the permanence of historic documents. Among the transition metals present, copper is the greatest threat and an open challenge due to the lack of Cu-specific treatments. In this study, we address the inhibition of copper by comparing extraction (a newly proposed glucose-based treatment) vs. Read More
J Chem Phys 2018 Dec;149(22):224505
Laboratory of Physical Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Building 14 (Helix), 5612 AZ Eindhoven, The Netherlands.
The centrifuge method is a novel, equilibrium-based, analytical procedure that allows the construction of solid-liquid phase diagrams of binary eutectic mixtures. In this paper, the development, optimization, and successful verification of the centrifuge method are described. Contrary to common dynamic analysis techniques-differential scanning calorimetry and hot-stage microscopy-the studied mixtures are equilibrated at constant temperature. Read More
Forensic Sci Int 2018 Dec 5;295:8-18. Epub 2018 Dec 5.
UMR Ingénierie Procédés Aliments, AgroParisTech, Inra, Université Paris-Saclay, 91300 Massy, France. Electronic address:
Recent research efforts in the domain of fire debris analysis have been mainly oriented towards the development of innovative analytical procedures and chemometric approaches for the detection and classification of ignitable liquids in fire specimens according to the ASTM E1618. However, less attention has been brought to the question of the source inference of ignitable liquids. Infer the identity of source of ignitable liquids recovered from arson sites is still a challenging and ongoing research area. Read More
Int J Food Microbiol 2018 Dec 7;292:13-20. Epub 2018 Dec 7.
University of Natural Resources and Life Sciences, Vienna (BOKU), Department of Agrobiotechnology (IFA-Tulln), Center for Analytical Chemistry, Konrad-Lorenz-Str. 20, 3430 Tulln, Austria.
Estimations of consumer exposure to mycotoxins through surveillance of mycotoxins in the food trade are well described, but the exposure due to mouldy food in private homes is not known, and may result from removing visible mould on food and eating the rest. In this study, we followed the growth of Penicillium expansum on the surface of apple jam and Penicillium verrucosum on crème fraiche, as well as production and distribution of fungal metabolites throughout the sample (approx. 6 cm high divided into three equal layers), using a multianalyte method, over time (up to 28 days) and at 4, 8 and 15 °C. Read More
Plant Physiol Biochem 2018 Dec 4;135:174-181. Epub 2018 Dec 4.
Division of Viticulture and Pomology, Department of Crop Sciences, University of Natural Resources and Life Sciences (BOKU), Vienna, Konrad Lorenz Str. 24, 3430, Tulln, Austria.
Many plants respond to herbivore attacks by the formation of secondary metabolites, such as polyphenols. Grape phylloxera (Daktulosphaira vitifoliaeFitch) induces organoid root galls on fibrous root tips of tolerant Vitis spp. rootstocks. Read More
J Chromatogr B Analyt Technol Biomed Life Sci 2018 Dec 6;1105:1-9. Epub 2018 Dec 6.
Laboratoire Réactions et Génie des Procédés, Université de Lorraine, CNRS, LRGP, F-54000 Nancy, France; Université de Lorraine, 2 Avenue de la forêt de Haye, F-54505 Vandœuvre-lès-Nancy, France. Electronic address:
This paper describes an original analytical methodology for a simultaneous measurement of the protein conversion rate, the mean molar weight of peptide and the degree of hydrolysis in the course of proteolysis by Size-Exclusion High-Performance Liquid Chromatography. Peak area of dead volume eluents reflects the non-converted protein. The protein conversion rate is thus determined by comparing the area at a given time to the initial area. Read More
J Environ Manage 2018 Dec 12;233:24-29. Epub 2018 Dec 12.
College of Environment and Resources, Xiangtan University, Xiangtan, 411105, China. Electronic address:
Microbial extracellular proteins serve as important functions in wastewater treatment process. Analysis of their compositions and properties is crucial to probe their specific functions. However, conventional analytical techniques cannot obtain interest protein information from complex proteins. Read More
Soc Sci Med 2018 Dec 7;221:1-8. Epub 2018 Dec 7.
University of Canberra, Australia. Electronic address:
Medical emergencies are staple features of today's 24/7 culture of breaking news. As politics becomes increasingly stylised, audiences fragmented, and established knowledge claims contested, health crises have become even more vulnerable to politicisation. We offer the vocabulary of medical populism to make sense of this phenomenon. Read More
Int J Biol Macromol 2018 Dec 12. Epub 2018 Dec 12.
Faculty of Pharmacy, Analytical Chemistry Department, Ege University, Bornova, Izmir 35100, Turkey; Biotechnology Department, Graduate School of Natural and Applied Sciences, Ege University, Bornova, Izmir 35100, Turkey.
Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation among people. Development of reliable methods for the detection of SNP is crucial in aspects of molecular diagnosis and personalized medicine. In our study, a genomagnetic assay in combination with zip nucleic acid (ZNA) for electrochemical detection of SNP related to Factor V Leiden (FV Leiden) mutation. Read More
Theor Popul Biol 2018 Dec 12. Epub 2018 Dec 12.
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA; Department of Mathematics, Harvard University, Cambridge, MA 02138, USA.
We describe an iterated game between two players, in which the payoff is to survive a number of steps. Expected payoffs are probabilities of survival. A key feature of the game is that individuals have to survive on their own if their partner dies. Read More
Clin Biochem 2018 Dec 12. Epub 2018 Dec 12.
RCPA Quality Assurance Programs, St Leonards, Sydney, NSW, Australia 2065. Electronic address:
Background: To minimise the risk of patient harm from results, laboratories should establish QC strategies and monitor the performance of assays in line with the analytical and clinical risk.
Methods: Steady state errors were calculated from a distribution normalized for an Analytical Performance Specification expressed as Assay Capability (imprecision) minus Assay Stability (drift). Inverting this error rate gave QC run length containing one error. Read More
Biotechnol Bioeng 2018 Dec 15. Epub 2018 Dec 15.
Merck Life Sciences, Upstream R&D, Frankfurter Strasse 250, Darmstadt, Germany.
Glycosylation is a key critical quality attribute for monoclonal antibodies and other recombinant proteins because of its impact on effector mechanisms and half-life. In this study, a variety of compounds were evaluated for their ability to modulate glycosylation profiles of recombinant monoclonal antibodies produced in Chinese hamster ovary cells. Compounds were supplemented into the cell culture feed of fed-batch experiments performed with a CHO K1 and a CHO DG44 cell line expressing a recombinant IgG1. Read More
Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.
Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, India.
Process analytical technology is gaining interest in the biopharmaceutical industry as a means to enable consistency in processing and thereby in product quality via process control. Protein refolding is known to be significantly impacted by critical process parameters and feed material attributes including composition and pH of the solubilization and refolding buffers. Hence, in order to achieve robust process control and product quality, these attributes and parameters need to be monitored. Read More
Pharmacoecon Open 2018 Dec 14. Epub 2018 Dec 14.
Academic Unit of Health Economics, Leeds Institute of Health Sciences, University of Leeds, Worsley Building, Clarendon Way, Leeds, LS2 9LJ, UK.
Diagnostic tests play an important role in the clinical decision-making process by providing information that enables patients to be identified and stratified to the most appropriate treatment and management strategies. Decision analytic modelling facilitates the synthesis of evidence from multiple sources to evaluate the cost effectiveness of diagnostic tests. This study critically reviews the methods used to model the cost effectiveness of diagnostic tests in UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) reports. Read More
Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.
Group of Analytical Spectrometry Applied, Faculty of Chemistry, Federal University of Pará, Belém, Pará, 66075-110, Brazil.
The aim of this study was to evaluate three digestion procedures using a diluted oxidant mixture of nitric acid, hydrogen peroxide, and water for determination of Cu, Fe, K, Mg, Mn, and Zn in shrimp and crab samples from Northern Brazil by microwave-induced plasma optical emission spectrometry. The efficiency of the digestion procedure was evaluated by comparing the residual carbon content, residual acidity, and elemental concentrations obtained in the samples. Digestion procedure 2 (4 mL HNO + 4 mL HO + 4 mL HO) was chosen due the adequate residual carbon content (5. Read More
Anal Bioanal Chem 2018 Dec 14. Epub 2018 Dec 14.
Department of Nanoengineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.
Edible electrochemical biosensors with remarkable prolonged resistance to extreme acidic conditions are described for direct glucose sensing in gastrointestinal (GI) fluids of different pH ranges and compositions. Such direct and stable glucose monitoring is realized using carbon-paste biosensors prepared from edible materials, such as olive oil and activated charcoal, shown to protect the activity of the embedded glucose oxidase (GOx) enzyme from strongly acidic conditions. The enzymatic resistance to low-pH deactivation allowed performing direct glucose monitoring in strong acidic environments (pH 1. Read More
Anal Bioanal Chem 2018 Dec 14. Epub 2018 Dec 14.
Nuclear Science and Engineering Center, Japan Atomic Energy Agency (JAEA), 2-4 Shirakata, Naka-gun, Ibaraki, 319-1195, Japan.
Determination of radiopalladium Pd is required to ensure radiation safety of the Pd extracted from spent nuclear fuel for recycling or disposal. We employed nanosecond laser ablation inductively coupled plasma quadrupole mass spectrometry (ns-LA-ICP-QMS) to simplify the analytical procedure of Pd. Pd was separated through a selective Pd precipitation reaction induced by pulsed laser irradiation that reduces Pd(II) ions to metal Pd(0). Read More
Anal Bioanal Chem 2018 Dec 14. Epub 2018 Dec 14.
Institute of Analytical and Bioanalytical Chemistry, Ulm University, 89081, Ulm, Germany.
In this study, carbon nanodots (CNDs) with excellent aqueous dispersibility, narrow size distribution, and oxygen-rich functional groups have been prepared via a green electrochemical method. Graphite electrodes were directly electrolyzed at ambient temperatures to form uniform CNDs in deionized water, which is free from additional oxidant/reductant. As-synthesized CNDs have been applied to coat an attenuated total reflection (ATR) waveguide enabling surface-enhanced infrared absorption (SEIRA) spectroscopic studies for detecting a variety of analytes in aqueous phase with remarkably enhanced IR band intensities. Read More
Nat Protoc 2018 Dec 14. Epub 2018 Dec 14.
Structure Elucidation Group, Process and Analytical Research and Development, Merck Research Laboratories, Rahway, NJ, USA.
The use of anisotropic NMR data, such as residual dipolar couplings (RDCs) and residual chemical shift anisotropies (RCSAs), has emerged as a powerful technique for structural characterization of organic small molecules. RDCs typically report the relative orientations of different H-C bonds; RCSAs report the relative orientations of different carbon chemical shielding tensors and hence are more useful for proton-deficient molecules. This information is complementary to that obtained from conventional NMR data such as J couplings, isotropic chemical shifts, and nuclear Overhauser effects (NOEs)/rotational frame nuclear Overhauser effects (ROEs). Read More
Sci Rep 2018 Dec 14;8(1):17877. Epub 2018 Dec 14.
Institute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", Patr. Grigoriou E' & Neapoleos 27, 15341, Athens, Greece.
Toxic cyanobacteria occur in Greek surface water bodies. However, studies on the occurrence of cyanotoxins (CTs) are often limited to mainly microcystins (MCs), with use of screening methods, such as ELISA, that are not conclusive of the chemical structure of the CT variants and can be subject to false positive results. A multi-lake survey in Greece (14 lakes) was conducted in water and biomass, targeted to a wide range of multi-class CTs including MCs, nodularin-R (NOD), cylindrospermopsin (CYN), anatoxin-a (ANA-a) and saxitoxins (STXs), using multi-class/variant LC-MS/MS analytical workflows, achieving sensitive detection, definitive identification and accurate quantitation. Read More
Sci Rep 2018 Dec 14;8(1):17853. Epub 2018 Dec 14.
University of Leiden, Leiden Institute of Chemistry, Einsteinweg 55, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
The solid-state photo-CIDNP (photochemically induced dynamic nuclear polarization) effect allows for increase of signal and sensitivity in magic-angle spinning (MAS) NMR experiments. The effect occurs in photosynthetic reaction centers (RC) proteins upon illumination and induction of cyclic electron transfer. Here we show that the strength of the effect allows for observation of the cofactors forming the spin-correlated radical pair (SCRP) in isolated proteins, in natural photosynthetic membranes as well as in entire plants. Read More
Nat Commun 2018 Dec 14;9(1):5327. Epub 2018 Dec 14.
Department of Chemistry, Seoul National University, Seoul, 08826, South Korea.
The synthesis of biophotonic crystals of insects, cubic crystalline single networks of chitin having large open-space lattices, requires the selective diffusion of monomers into only one of two non-intersecting water-channel networks embedded within the template, ordered smooth endoplasmic reticulum (OSER). Here we show that the topology of the circumferential bilayer of polymer cubosomes (PCs)-polymeric analogues to lipid cubic membranes and complex biological membranes-differentiate between two non-intersecting pore networks embedded in the cubic mesophase by sealing one network at the interface. Consequently, single networks having large lattice parameters (>240 nm) are synthesized by cross-linking of inorganic precursors within the open network of the PCs. Read More
Nat Commun 2018 Dec 14;9(1):5322. Epub 2018 Dec 14.
Department of Applied Physics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Obtaining accurate properties of many-body interacting quantum matter is a long-standing challenge in theoretical physics and chemistry, rooting into the complexity of the many-body wave-function. Classical representations of many-body states constitute a key tool for both analytical and numerical approaches to interacting quantum problems. Here, we introduce a technique to construct classical representations of many-body quantum systems based on artificial neural networks. Read More
BMJ Open 2018 Dec 14;8(12):e024095. Epub 2018 Dec 14.
Primary Health Care Research Unit, La Alamedilla Health Center, Institute of Biomedical Research of Salamanca (IBSAL), Health Service of Castilla y León (SACyL), Salamanca, Spain.
Introduction: The intake of polyphenols has certain health benefits. This study will aim to assess the effect of adding a daily amount of chocolate high in cocoa content and polyphenols to the normal diet on blood pressure, vascular function, cognitive performance, quality of life and body composition in postmenopausal women.
Methods And Analysis: Here we plan a randomised clinical trial with two parallel groups involving a total of 140 women between 50 and 64 years in the postmenopausal period, defined by amenorrhoea of at least 12 consecutive months. Read More
BMJ Open 2018 Dec 14;8(12):e022931. Epub 2018 Dec 14.
Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.
Introduction: The rising popularity of social media, since their inception around 20 years ago, has been echoed in the growth of health-related research using data derived from them. This has created a demand for literature reviews to synthesise this emerging evidence base and inform future activities. Existing reviews tend to be narrow in scope, with limited consideration of the different types of data, analytical methods and ethical issues involved. Read More
Biosci Rep 2018 Dec 14. Epub 2018 Dec 14.
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, 30324, United States
Influenza viruses cause seasonal epidemics and sporadic pandemics in humans. The virus's ability to change its antigenic nature through mutation and recombination, and the difficulty in developing highly effective universal vaccines against it, make it a serious global public health challenge. Influenza virus's surface glycoproteins, hemagglutinin and neuraminidase, are all modified by the host cell's N-linked glycosylation pathways. Read More
J Chromatogr A 2018 Dec 5. Epub 2018 Dec 5.
Analytical R&D, Pfizer BioTherapeutics R&D Pharmaceutical Sciences, 700 Chesterfield Parkway West, Chesterfield, MO 63017, United States.
Polysorbates are complex mixtures of over a thousand components with a wide range of hydrophobicity. This paper describes a methodology for characterization of heterogeneity and stability of polysorbates in therapeutic protein formulation. The method utilizes on-line coupling of a hydrophobic interaction chromatography (HIC) column with reverse phase liquid chromatography (RPLC) and charged aerosol detection (CAD)/mass spectrometer (MS). Read More
Biochem Biophys Res Commun 2018 Dec 11. Epub 2018 Dec 11.
Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan; The OCU Advanced Research Institute for Natural Science and Technology (OCARINA), Osaka City University, Osaka, Japan. Electronic address:
Mycoplasma pneumoniae forms an attachment organelle at one cell pole, binds to the host cell surface, and glides via a unique mechanism. A 170-kDa protein, P1 adhesin, present on the organelle surface plays a critical role in the binding and gliding process. In this study, we obtained a recombinant P1 adhesin comprising 1476 amino acid residues, excluding the C-terminal domain of 109 amino acids that carried the transmembrane segment, that were fused to additional 17 amino acid residues carrying a hexa-histidine (6 × His) tag using an Escherichia coli expression system. Read More
Biochem Biophys Res Commun 2018 Dec 11. Epub 2018 Dec 11.
Laboratory of Structural Biochemistry of Proteins, Bach Institute of Biochemistry, Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, Leninsky pr. 33, Moscow, 119071, Russia.
Small heat shock proteins (sHsps) are molecular chaperones preventing protein aggregation. Dynamics of quaternary structure plays an important role in the chaperone-like activity of sHsps. However, an interrelation between the oligomeric state and chaperone-like activity of sHsps remains insufficiently characterized. Read More
J Pers Med 2018 Dec 13;8(4). Epub 2018 Dec 13.
Northern Ireland Centre for Stratified Medicine, Altnagelvin Hospital Campus, Ulster University, Londonderry, BT47 6SB, Northern Ireland, UK.
Multiple genes and mechanisms of pathophysiology have been implicated in amyotrophic lateral sclerosis (ALS), suggesting it is a complex systemic disease. With this in mind, applying personalized medicine (PM) approaches to tailor treatment pipelines for ALS patients may be necessary. The modelling and analysis of molecular interaction networks could represent valuable resources in defining ALS-associated pathways and discovering novel therapeutic targets. Read More
Mar Drugs 2018 Dec 13;16(12). Epub 2018 Dec 13.
Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore 637616, Singapore.
Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins present in four environmental marine cyanobacterial samples collected from intertidal areas in Singapore. Based on 16S-ITS rRNA gene sequences, these filamentous cyanobacterial samples collected from Pulau Hantu were determined as , sp. Read More
Sports (Basel) 2018 Dec 13;6(4). Epub 2018 Dec 13.
Department of Sport Science, Karlsruhe Institut of Technology, 76131 Karlsruhe, Germany.
Emotional intelligence (EI) is considered as a factor influencing sport performance. The research findings are inconsistent with respect to the size and even the direction of the relationship, however. In order to summarise the available evidence, we conducted a meta-analysis examining the relationship between emotional intelligence (EI) and sports performance in competitive sports. Read More
Sensors (Basel) 2018 Dec 13;18(12). Epub 2018 Dec 13.
R&D Center of HealthCare Electronics, Institute of Microelectronics of Chinese Academy of Sciences, Beijing 100029, China.
Carbonyl compounds in water sources are typical characteristic pollutants, which are important indicators in the health risk assessment of water quality. Commonly used analytical chemistry methods face issues such as complex operations, low sensitivity, and long analysis times. Here, we report a silicon microfluidic device based on click chemical surface modification that was engineered to achieve rapid, convenient and efficient capture of trace level carbonyl compounds in liquid solvent. Read More