9,648 results match your criteria Analytica Chimica Acta[Journal]


Rapid pre-concentration of mercury in solids and water for isotopic analysis.

Anal Chim Acta 2019 Apr 21;1054:95-103. Epub 2018 Dec 21.

United States Geological Survey, Upper Midwest Water Science Center, Middleton, WI, 53562, USA.

The precise quantification of mercury (Hg) stable isotope compositions in low concentration or dilute samples poses analytical challenges due to Hg mass limitations. Common Hg pre-concentration procedures require extended processing times, making rapid Hg stable isotope measurements challenging. Here we present a modified pre-concentration method that combines commonly used Hg reduction and gold trap amalgamation followed by semi-rapid thermal desorption (less than 1 h) and chemical trapping. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183147
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http://dx.doi.org/10.1016/j.aca.2018.12.026DOI Listing
April 2019
6 Reads

Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry.

Anal Chim Acta 2019 Apr 21;1054:84-94. Epub 2018 Dec 21.

Mass Spectrometry Core, Edinburgh Clinical Research Facility, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom. Electronic address:

Estrogens regulate many diverse biological processes in health and disease. They circulate at a wide range of concentrations in females generating several active metabolites (hydroxy and methoxyestrogens). The metabolites are assumed to be present in much lower levels and are thought to contribute to diseases such as pulmonary arterial hypertension (PAH). Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363983PMC

Tracing oxidation reaction pathways in wine using C isotopolog patterns and a putative compound database.

Anal Chim Acta 2019 Apr 15;1054:74-83. Epub 2018 Dec 15.

Department of Viticulture and Enology, University of California, Davis, CA, 95616, USA. Electronic address:

Quinones are key reactive electrophilic intermediates that are formed in abundance during wine oxidation and have a significant impact on wine character, altering color and flavor. They readily react with nucleophiles, such as SO and glutathione. Some nucleophiles have been reported to react with quinones in model wines, but many of the corresponding products have not been confirmed in real wines. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.019DOI Listing
April 2019
1 Read

High-resolution mass spectrometry-based multi-residue method covering relevant steroids, stilbenes and resorcylic acid lactones in a variety of animal-based matrices.

Anal Chim Acta 2019 Apr 15;1054:59-73. Epub 2018 Dec 15.

Official Food Control Authority of the Canton of Zürich, Fehrenstrasse 15, 8032, Zürich, Switzerland.

A new, relatively simple sample processing and detection workflow has been developed for the quantification and confirmation of banned growth-promoting substances in a wide variety of animal-based food products. The method covers all required compounds (belonging to the so-called A1, A3, A4 and B2f groups as termed by the relevant EU legislation) which are currently monitored by the official European community surveillance programs. The sample processing includes a thermal sample denaturation step, intended to prevent undesirable side-reactions during the following enzymatic deconjugation of covalently bound analytes. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.012DOI Listing

Ionic liquid modified molybdenum disulfide and reduced graphene oxide magnetic nanocomposite for the magnetic separation of dye from aqueous solution.

Anal Chim Acta 2019 Apr 21;1054:47-58. Epub 2018 Dec 21.

Department of Microbiology, College of Basic Medicine, Central South University, Changsha, 410083, PR China.

A novel ionic liquid (IL) modified magnetic nanocomposite (mag-MoS-RGO), which was composed of molybdenum disulfide (MoS) and reduced graphene oxide (RGO), was firstly synthesized and characterized (mag-MoS-RGO-IL). Compared with mag-MoS-RGO, the mag-MoS-RGO-IL exhibited the higher adsorption capacity of 143.9 mg/g for methylene blue (MB) under optimum conditions. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.037DOI Listing
April 2019
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Magnetic γ-cyclodextrin polymer with compatible cavity promote the magnetic solid-phase extraction of microcystins in water samples.

Anal Chim Acta 2019 Apr 21;1054:38-46. Epub 2018 Dec 21.

Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China. Electronic address:

Microcystins (MCs), which are produced by eruptive cyanobacteria, seriously threaten the health of humans for their poisonousness. Herein, a facile strategy was introduced to synthesize the magnetic γ-cyclodextrin polymer (FeO@PDA@γ-CDP) composite and set it as a novel adsorbent with excellent properties for the magnetic solid-phase extraction (MSPE) of MCs. The prepared FeO@PDA@γ-CDP microspheres exhibit good aqueous dispersibility and highly affinity for MCs, thus contribute to an excellent extraction performance for trace MCs in water samples. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.028DOI Listing

New passive sampling device for effective monitoring of pesticides in water.

Anal Chim Acta 2019 Apr 24;1054:26-37. Epub 2018 Dec 24.

Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, 31270901, Belo Horizonte, MG, Brazil. Electronic address:

The extensive use of pesticides promotes environmental contamination, mainly in surface and ground waters. However, they remain at very low concentration and present wide degradation level requiring the use of efficient devices for pesticides passive sampling. In this study, a new in situ passive sampling device was developed for monitoring and estimating time-weighted average (TWA) of pesticides in waters. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.017DOI Listing
April 2019
1 Read

Analysis of charged acrylic particles by on-line comprehensive two-dimensional liquid chromatography and automated data-processing.

Anal Chim Acta 2019 Apr 9;1054:184-192. Epub 2019 Jan 9.

University of Amsterdam, van 't Hoff Institute for Molecular Sciences, Analytical-Chemistry Group, Science Park 904, 1098 XH, Amsterdam, the Netherlands.

A thorough understanding of particle formation and polymer growth during emulsion polymerization is indispensable for the development of particles and products with very specific properties. This has created a demand for the detailed characterization of various properties and property distributions - and the relation between these. A method is described that enables comprehensive, simultaneous determination of the size distribution of nanoparticles and the molecular-weight distribution of the constituting polymers as a function of the particle size. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.059DOI Listing
April 2019
2 Reads

Developed magnetic multiporous 3D N-Co@C/HCF as efficient sorbent for the extraction of five trace phthalate esters.

Anal Chim Acta 2019 Apr 27;1054:176-183. Epub 2018 Dec 27.

College of Chemistry, Liaoning University, Shenyang, 110036, China. Electronic address:

A three-dimensional (3D) magnetic porous N-Co@carbon dodecahedron/hierarchical carbon framework (3D N-Co@C/HCF) hybrid has been successfully synthesized by integration of the ZIF-67 into HCF and then calcination under an inert gas (N). 3D N-Co@C/HCF as magnetic sorbent show good extraction ability for phthalate esters (PAEs: dibutyl phthalate (DBP), dimethyl phthalate (DMP), dicyclohexyl phthalate (DCHP), butyl benzyl phthalate (BBP), diethyl phthalate (DEP)). This is attributed not only to the abundant adsorption sites (due to the presence of large specific surface area) and the extremely strong π-conjugated system of 3D N-Co@C/HCF, but also to sufficient contact spaces and facile transport channels (ascribe to the interconnected hierarchical 3D porous structure) between targets and the material. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.046DOI Listing
April 2019
4.513 Impact Factor

Determination and elimination of hazardous pollutants by exploitation of a Prussian blue nanoparticles-graphene oxide composite.

Anal Chim Acta 2019 Apr 15;1054:17-25. Epub 2018 Dec 15.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, No.135, Xingang Xi Road, Guangzhou, Guangdong, 510275, China. Electronic address:

The exploitation of desired materials with specific properties for water remediation has become an irresistible trend. Generally, materials favorable to the elimination of hazardous contaminants are always beneficial to the detection of these compounds. Nevertheless, few researches combined these two procedures into a treating line. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.011DOI Listing

Label-free fluorescent discrimination and detection of epinephrine and dopamine based on bioinspired in situ copolymers and excitation wavelength switch.

Anal Chim Acta 2019 Apr 21;1054:167-175. Epub 2018 Dec 21.

Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China. Electronic address:

A simple and label-free fluorescence turn-on method is proposed for the discrimination and detection of epinephrine (Ep) and dopamine (DA) via polyethyleneimine (PEI)-initiated in situ copolymerization and excitation wavelength switch. The PEI solution in the presence of Ep, DA and the mixture of Ep and DA are denoted as P, P and M, respectively. In this study, PEI aqueous solution medium initiates the auto-oxidization of Ep and DA and the bioinspired copolymerization. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.030DOI Listing
April 2019
1 Read

Rapid and specific detection of Salmonella infections using chemically modified nucleic acid probes.

Anal Chim Acta 2019 Apr 21;1054:157-166. Epub 2018 Dec 21.

Department of Physics, Chemistry and Biology, Linkӧping University, Linköping, 58185, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Linköping University, Linköping, Sweden. Electronic address:

Salmonella is a leading source of bacterial foodborne illness in humans, causing gastroenteritis outbreaks with bacteraemia occurrences that can lead to clinical complications and death. Eggs, poultry and pig products are considered as the main carriers of the pathogenic Salmonella for humans. To prevent this relevant zoonosis, key changes in food safety regulations were undertaken to improve controls in the food production chain. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.027DOI Listing
April 2019
2 Reads
4.513 Impact Factor

Mustard seeds derived fluorescent carbon quantum dots and their peroxidase-like activity for colorimetric detection of HO and ascorbic acid in a real sample.

Anal Chim Acta 2019 Apr 20;1054:145-156. Epub 2018 Dec 20.

Nano Material Research Laboratory, Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, 221005, U.P., India. Electronic address:

Herein, we were synthesized fluorescent carbon quantum dots via facile one-step hydrothermal treatment of mustard seeds (M-CQDs). It showed excellent optical property with fluorescent quantum yield 4.6%. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.024DOI Listing
April 2019
2 Reads
4.513 Impact Factor

A dual-channel probe with green and near-infrared fluorescence changes for in vitro and in vivo detection of peroxynitrite.

Anal Chim Acta 2019 Apr 15;1054:137-144. Epub 2018 Dec 15.

Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Central China Normal University, 152 Luoyu Road, Wuhan, 430079, PR China. Electronic address:

In this study, a coumarin-semirhodamine hybrid based dual-channel fluorescent probe was developed for detection of peroxynitrite. This probe works well in nearly pure aqueous solution and displays a rapid, highly sensitive and selective response for peroxynitrite at two different emission wavelengths (700 and 515 nm, respectively), along with distinct color and green to near-infrared fluorescence changes. The fluorescent intensity ratio at 700 and 515 nm increases linearly with the concentration of peroxynitrite from 0 to 50 μM, and the detection limit is estimated to be 59 nM. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.021DOI Listing

Double-integrated mimic enzymes for the visual screening of Microcystin-LR: Copper hydroxide nanozyme and G-quadruplex/hemin DNAzyme.

Anal Chim Acta 2019 Apr 15;1054:128-136. Epub 2018 Dec 15.

College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

Recently, mimic enzymes have obtained particular interest by their high activity, stability, and biocompatibility. In this work, by coupling copper hydroxide nanozyme and G-quadruplex/hemin DNAzyme to form a double-integrated mimic enzyme, a visual, sensitive and selective immunosensor was established to detect microcystin-LR (MC-LR). In this immunoassay, the microplates were modified with core-shell silica/nickel silicate as the substrate to capture MC-LR antigens. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.018DOI Listing
April 2019
1 Read

Smartphone-based apparatus for measuring upconversion luminescence lifetimes.

Authors:
Zece Zhu

Anal Chim Acta 2019 Apr 20;1054:122-127. Epub 2018 Dec 20.

Wuhan National Laboratory for Optoelectronics & School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address:

Luminescence lifetime detection plays an important role in time-resolved detection and research. However, the traditional instruments always require expensive detectors such as time-correlated single photon counter or streak camera. Herein, a low-cost and miniaturized apparatus for measuring upconversion luminescence lifetimes was developed by using a smartphone equipped with a 980 nm CW laser and a motor. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.016DOI Listing
April 2019
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Use of MALDI-MS with solid-state hydrogen deuterium exchange for semi-automated assessment of peptide and protein physical stability in lyophilized solids.

Anal Chim Acta 2019 Apr 9;1054:114-121. Epub 2019 Jan 9.

Merck & Co., Inc., Merck Research Laboratories, Process Research & Development, Rahway, NJ, 07065, USA. Electronic address:

Biological therapeutics are established as major contributors to the pharmaceutical pipeline. Many of these biological drugs are lyophilized to preserve their conformation and reduce decomposition during storage and shipping. Therefore, understanding and controlling the effects of lyophilization on protein higher order structure is critical for commercialization of biologics. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.034DOI Listing

Mass spectrometric imaging reveals photocatalytic degradation intermediates of aromatic organochlorines resulting from interfacial photoelectron transfer and hydroxyl radical abstraction on semiconductor nanoparticles.

Anal Chim Acta 2019 Apr 21;1054:104-113. Epub 2018 Dec 21.

Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079, PR China. Electronic address:

Organochlorines are highly persistent and toxic contaminants that are widely distributed and accumulated in various aquatic or soil environments as well as food chains. Heterogeneous photocatalytic degradation of such pollutants by using semiconductor nanoparticles has been recognized as one of the effective purification ways. Understanding of degradation mechanisms and designing of highly efficient semiconductor nanoparticles require structural identification of various degradation intermediates that are difficult to achieve with current spectroscopic techniques. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.032DOI Listing

Analytical applications and physicochemical properties of ionic liquid-based hybrid materials: A review.

Anal Chim Acta 2019 Apr 5;1054:1-16. Epub 2018 Nov 5.

Gdansk University of Technology, Faculty of Chemistry, Department of Physical Chemistry, Narutowicza Str.11/12, Gdansk, 80-233, Poland.

Ionic liquids with their unique properties found so far numerous analytical applications. Among them ionic liquids immobilized on the surface or within the pores of a solid support were successfully utilized in extraction techniques dedicated to preconcentration of the analytes from food, environmental and biological samples. In this review we focus on comprehensive summarizing of available literature data on the examples of ionic liquid-based hybrid materials implementation in selected analytical extraction techniques, namely solid-phase extraction, solid-phase microextraction, hollow-fiber solid-phase microextraction, stir-bar sorptive extraction and biosensors. Read More

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http://dx.doi.org/10.1016/j.aca.2018.10.061DOI Listing
April 2019
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A novel ELISA for the detection of active form of plasminogen activator inhibitor-1 based on a highly specific trapping agent.

Anal Chim Acta 2019 Apr 12;1053:98-104. Epub 2018 Dec 12.

State Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China; College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China. Electronic address:

Plasminogen activator inhibitor-1 (PAI-1) is a labile molecule that exists in four different forms: active, latent, cleaved and target bound form. Although there have been many methods to measure the total PAI-1, the measurement of active form of PAI-1 antigen is still challenging. Here we developed a novel ELISA to detect the active form of PAI-1 based on a highly specific PAI-1 capturing agent which binds to active PAI-1 with high affinity. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.005DOI Listing

In situ formation of fluorescent polydopamine catalyzed by peroxidase-mimicking FeCo-LDH for pyrophosphate ion and pyrophosphatase activity detection.

Anal Chim Acta 2019 Apr 12;1053:89-97. Epub 2018 Dec 12.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.

As pyrophosphate ion (PPi) and pyrophosphatase (PPase) play crucial roles in the pathological process of arthritis, determination of PPi and PPase in biological fluids turns to be of great importance for clinical diagnosis and therapy of arthritic diseases. In this work, we proposed a new fluorescent assay for PPi and PPase activity detection based on the competitive coordination chemistry of Fe between PPi and an in situ formed fluorescent polydopamine (PDA). FeCo layered double hydroxide (FeCo-LDH) was explored as a peroxidase mimic to facilitate the in situ formation of fluorescent PDA from dopamine mediated by low-concentration HO within 30 min; The formed fluorescent PDA could be significantly quenched by Fe through forming a PDA-Fe complex structure; When PPi existed, it coordinated Fe competitively against PDA and inhibited the fluorescence quenching of PDA by Fe; When PPi was hydrolyzed under the catalysis of PPase, the Fe ion could quench the fluorescence of the formed PDA again. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183142
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http://dx.doi.org/10.1016/j.aca.2018.12.006DOI Listing
April 2019
2 Reads

Visualization of endogenous hydrogen sulfide in living cells based on Au nanorods@silica enhanced fluorescence.

Anal Chim Acta 2019 Apr 15;1053:81-88. Epub 2018 Dec 15.

School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, United States. Electronic address:

Hydrogen sulfide as a gas indicator molecule plays an important role in various human physiological processes. However, due to the high volatility and diffusivity of HS in biological systems, it is very difficult to implement a precise assay for HS detection. Compared with the destructive instrumental methods, assays based on fluorescence probes provide noninvasive and real-time detections of HS in living cells. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.008DOI Listing

Encoded particle microfluidic platform for rapid multiplexed screening and characterization of aptamers against influenza A nucleoprotein.

Anal Chim Acta 2019 Apr 5;1053:70-80. Epub 2018 Dec 5.

Department of Biosystems, Biosensors Group, KU Leuven, Willem de Croylaan 42, 3001, Leuven, Belgium. Electronic address:

Aptamers represent interesting bioreceptor alternatives to antibodies when developing a bioassay and are selected by the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) process. After selection, an extensive characterization process is essential to verify the binding affinity and specificity of aptamer candidates, which is the most time-consuming and costly step. In this study, we assessed a new microfluidic platform, namely Evalution™, as a rapid and high throughput aptamer characterization platform. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.055DOI Listing
April 2019
1 Read

On-line microfluidic immobilized-enzyme reactors: A new tool for characterizing synthetic polymers.

Anal Chim Acta 2019 Apr 12;1053:62-69. Epub 2018 Dec 12.

Universiteit van Amsterdam, Van 't Hoff Institute for Molecular Sciences, Science Park 904, 1098 XH, Amsterdam, the Netherlands.

Biodegradable polymeric materials may eventually replace biostable materials for medical applications, including therapeutic devices, scaffolds for tissue engineering, and drug-delivery vehicles. To further develop such materials, a more fundamental understanding is necessary to correlate parameters including chemical-composition distribution within a macromolecular structure with the final properties of the material, including particle-size. A wide variety of analytical techniques have been applied for the characterization of polymer materials, including hyphenated techniques such as comprehensive two-dimensional liquid chromatography (LC × LC). Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.002DOI Listing
April 2019
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Spectrophotometric flow injection determination of dissolved titanium in seawater exploiting in-line nitrilotriacetic acid resin preconcentration and a long path length liquid waveguide capillary cell.

Anal Chim Acta 2019 Apr 19;1053:54-61. Epub 2018 Nov 19.

State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 361102, China; College of Ocean and Earth Sciences, Xiamen University, Xiamen, 361102, China.

A sensitive spectrophotometric method for the determination of dissolved titanium (Ti) in seawater is developed. It involves in-line preconcentration and a long path length liquid waveguide capillary cell (LWCC). Nitrilotriacetic acid (NTA) resin is used to preconcentrate Ti from ∼25 mL seawater sample at pH 1. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.034DOI Listing
April 2019
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Facile fabrication of zwitterionic magnetic composites by one-step distillation-precipitation polymerization for highly specific enrichment of glycopeptides.

Anal Chim Acta 2019 Apr 12;1053:43-53. Epub 2018 Dec 12.

CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address:

Hydrophilic interaction chromatography (HILIC) utilizing zwitterion-modified material as solid phase has attracted extensive attention for selective enrichment of glycopeptides. However, a tedious synthesis and low specificity for glycopeptides have restricted its application. Herein, a facile and effective approach was developed to synthesize a zwitterionic (ZIC) polymer-coated magnetic composites (denoted as FeO@PMSA) with a zwitterion ((2-(methacryloyloxy)ethyl)-dimethyl-(3-sulfopropyl) ammonium hydroxide, MSA) via one-step distillation-precipitation polymerization (DPP). Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.003DOI Listing
April 2019
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Photochemical multivariate curve resolution models for the investigation of photochromic systems under continuous irradiation.

Anal Chim Acta 2019 Apr 12;1053:32-42. Epub 2018 Dec 12.

Univ. Lille, CNRS, UMR 8516 - LASIR - Laboratoire de Spectrochimie Infrarouge et Raman, 59000, Lille, France. Electronic address:

We propose a multivariate curve resolution approach for the investigation of photochromic systems using UV-Visible spectroscopy. The incorporation of photochemical hard-models as constraints in multivariate curve resolution alternating least squares (MCR-ALS) allows extracting reaction quantum yields in situations where a complete knowledge of the system is not available. We apply this approach to the study of the photochromism of CMTE (cis-1,2-dicyano-1,2-bis(2,4,5-trimethyl-3-thienyl)ethene) under continuous monochromatic irradiation. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.004DOI Listing

Novel non-targeted analysis of perfluorinated compounds using fluorine-specific detection regardless of their ionisability (HPLC-ICPMS/MS-ESI-MS).

Anal Chim Acta 2019 Apr 20;1053:22-31. Epub 2018 Nov 20.

Trace Element Speciation Laboratory (TESLA), Department of Chemistry, University of Aberdeen, Aberdeen, AB24 3UE, United Kingdom. Electronic address:

Although perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) have been phased out, there is a plethora of per- or polyfluoroalkyl substances (PFAS) generated and only a small number of these compounds are currently being monitored in environmental and biological sample using molecular mass spectrometry (MS). Total fluorine determination has revealed that a substantial amount of fluorinated organic compounds has not been identified. Due to the small mass deficiency of fluorine, it is not an easy task to screen successfully all fluorinated compounds including those which are not easy ionisable, hence a novel fluorine-specific detector is needed. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.037DOI Listing

Absolute molar mass determination in mixed solvents. 1. Solving for the SEC/MALS/DRI "trivial" case.

Anal Chim Acta 2019 Apr 5;1053:186-195. Epub 2018 Dec 5.

Chemical Sciences Division, National Institute of Standards and Technology (NIST), 100 Bureau Drive, MS 8392, Gaithersburg, MD, 20899-8392, USA.

Size-exclusion chromatography (SEC) with on-line static light scattering, specifically multi-angle static light scattering (MALS), and differential refractometry (DRI) detection remains the premier method by which to determine absolute, calibrant-independent molar masses of polymers. The method is restricted to the use of either neat solvents or solvents with a small amount of additive. In mixed solvents, preferential solvation (i. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.051DOI Listing
April 2019
2 Reads

Analytical strategy based on asymmetric flow field flow fractionation hyphenated to ICP-MS and complementary techniques to study gold nanoparticles transformations in cell culture medium.

Anal Chim Acta 2019 Apr 5;1053:178-185. Epub 2018 Dec 5.

Department of Analytical Chemistry and Food Technology, Faculty of Chemical Sciences and Technologies, University of Castilla-La Mancha, Avda. Camilo José Cela s/n, 13071, Ciudad Real, Spain. Electronic address:

An analytical methodology based on asymmetric flow field flow fractionation (AF4) hyphenated to inductively coupled plasma mass spectrometry (ICP-MS) has been developed to study gold nanoparticles (AuNPs) in cell culture medium (Dulbecco's Modified Eagle Medium, DMEM, containing 10% fetal bovine serum, FBS, and antibiotics) used for in vitro toxicological studies. AF4-ICP-MS separation of AuNPs was performed using a regenerated cellulose membrane (molecular weight cut-off, MWCO, of 10 kDa). The carrier composition and the AF4 separation program were optimized. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.053DOI Listing

Large-volume injection gas chromatography-vacuum ultraviolet spectroscopy for the qualitative and quantitative analysis of fatty acids in blood plasma.

Anal Chim Acta 2019 Apr 15;1053:169-177. Epub 2018 Dec 15.

Department of Chemistry and Biochemistry, University of Texas Arlington, Arlington, TX, USA. Electronic address:

Qualitative and quantitative determination of fatty acids in plasma is of extreme importance as these are indicators of metabolic diseases. In this work, a sensitive and rugged method for detecting and quantifying fatty acids (as fatty acid methyl ester derivatives, FAMEs) in blood plasma was developed. The use of large-volume injection (LVI) gas chromatography-vacuum ultraviolet spectroscopy (GC-VUV) for analysis of fatty acids in blood plasma allowed the injection of higher sample volumes to accommodate sufficient analyte on-column for necessary detection ranges with a run time of 45 min. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.007DOI Listing

Capillary electrophoresis with preparative isoelectric focusing preconcentration for sensitive determination of amphotericin B in human blood serum.

Anal Chim Acta 2019 Apr 18;1053:162-168. Epub 2018 Dec 18.

Institute of Analytical Chemistry of the CAS, v. v. i., Veveří 97, 602 00, Brno, Czech Republic.

Amphotericin B (AmB) is still, despite its severe nephrotoxicity, the first-line agent in the management of serious systemic fungal infections. A sensitive and reliable method is therefore required to control AmB concentration in body fluids of a patient. This study demonstrates the potential of the off-line combination of preparative isoelectric focusing (IEF) with capillary isoelectric focusing (CIEF) or capillary zone electrophoresis (CZE) in the determination of AmB in human blood serum. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.010DOI Listing

Colorimetric copper ion sensing in solution phase and on paper substrate based on catalytic decomposition of S-nitrosothiol.

Anal Chim Acta 2019 Apr 5;1053:155-161. Epub 2018 Dec 5.

Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, MI, 48109, USA. Electronic address:

A S-nitrosothiol (RSNO) is used for highly selective and sensitive copper ion sensing for the first time. Cu(II) in the sample is reduced to Cu(I) by a low amount of thiols generated from hydrolysis of RSNO molecules or added thiols such as l-glutathione or l-cysteine. Cu(I) is able to trigger cleavage of the SNO bond, which converts colored RSNOs to colorless products. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183140
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http://dx.doi.org/10.1016/j.aca.2018.11.050DOI Listing
April 2019
2 Reads
4.513 Impact Factor

A FRET-based ratiometric fluorescent probe for detection of intrinsically generated SO derivatives in mitochondria.

Anal Chim Acta 2019 Apr 5;1053:148-154. Epub 2018 Dec 5.

School of Chemistry and Pharmaceutical Engineering, Taishan Medical University, Taian, Shandong, 271016, PR China. Electronic address:

A mitochondria-targeted ratiometric fluorescent probe based on hemicyanine and pyrido[1,2-a]benzimidazole was presented. It shows high sensitivity and selectivity toward SO in pure water. The limit of detection (LOD) was as low as 26. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.052DOI Listing

Ultrasensitive detection of avian influenza A (H7N9) virus using surface-enhanced Raman scattering-based lateral flow immunoassay strips.

Anal Chim Acta 2019 Apr 7;1053:139-147. Epub 2018 Dec 7.

Department of Bioengineering, Guangdong Province Engineering Research Center for Antibody Drug and Immunoassay, Jinan University, Guangzhou, 510632, PR China; Institute of Food Safety and Nutrition, Jinan University, Guangzhou, 510632, PR China. Electronic address:

The development of biosensors that are portable, low-cost, and quantitative has long been sought for rapid, on-site, and timely detection of avian influenza virus (AIV). In this study, an antibody-based Raman lateral flow immunoassay strip was developed to detect AIV H7N9. This LFIA strip used a novel core-shell structure material, AuAg@AgNPs, as a Raman probe. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.056DOI Listing
April 2019
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4.513 Impact Factor

Low-cost fabrication of a paper-based microfluidic using a folded pattern paper.

Anal Chim Acta 2019 Apr 6;1053:131-138. Epub 2018 Dec 6.

School of Sino-Dutch Biomedical and Information Engineering, Northeastern University, Shenyang, 110819, Liaoning, China.

Despite that microfluidic paper-based analytical devices (μPADs) provide effective analytical platforms for point-of-care diagnosis in resource-limited areas, it remains challenging to achieve simple and low-cost fabrication of μPADs. A novel method for fabrication of μPADs is developed in this study using a folded polydimethylsiloxane (PDMS)-coated paper mask with a specific pattern to form a sandwich structure with inserted chromatographic paper. PDMS penetrates the target paper from the front and the back sides, and then is cured in the target paper to form legible channels. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.001DOI Listing
April 2019
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Ultrasensitive detection of telomerase activity in lung cancer cells with quencher-free molecular beacon-assisted quadratic signal amplification.

Anal Chim Acta 2019 Apr 7;1053:122-130. Epub 2018 Dec 7.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan, 250014, China. Electronic address:

Telomerase is an important biomarker for cancer diagnosis and a valuable target for cancer therapy. Most of the reported telomerase assays suffer from the repeating thermal cycles, laborious protocols, expensive instruments and the limited sensitivity. To solve these issues, we develop a new telomerase assay based on telomerization-driven release of fluorescent 2-aminopurine. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.058DOI Listing
April 2019
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Fluorescence-enhanced p19 proteins-conjugated single quantum dot with multiplex antenna for one-step, specific and sensitive miRNAs detection.

Anal Chim Acta 2019 Apr 7;1053:114-121. Epub 2018 Dec 7.

Department of Chemistry, Liaocheng University, Liaocheng, 252059, Shandong, China. Electronic address:

Ideal methods for miRNA detection should be rapid and amplification-free in the mix-and-measure format. Here we report a novel FRET strategy based on fluorescence-enhanced p19 proteins-conjugated single quantum dot (QD) with multiplex antenna for one-step, specific and sensitive miRNAs quantitative analysis. It is simple in design and operation, and possesses high sensitivity and selectivity. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.060DOI Listing

Multifunctional G-quadruplex-based fluorescence probe coupled with DNA-templated AgNCs for simultaneous detection of multiple DNAs and MicroRNAs.

Anal Chim Acta 2019 Apr 12;1053:105-113. Epub 2018 Dec 12.

Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, China. Electronic address:

A rapid, label-free, and multifunctional fluorescent probe for simultaneous detection of multiple targets was fabricated based on G-quadruplexes and DNA-templated silver nanoclusters (AgNCs). In this work, a probe with two capitated recognized regions was coupled with a locked G-quadruplex at the 5'-terminus and dark AgNC at the 3'-terminus. Upon the addition of the virus subtype H5N1 gene or microRNA-141, only the sequence of the G-quadruplex was released and bound with Thioflavin T (ThT) for a specific fluorescent response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183142
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http://dx.doi.org/10.1016/j.aca.2018.11.062DOI Listing
April 2019
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Microfluidic and cross-linking methods for encapsulation of living cells and bacteria - A review.

Anal Chim Acta 2019 Apr 12;1053:1-21. Epub 2019 Jan 12.

Faculty of Sustainable Design Engineering, University of Prince Edward Island, Charlottetown, PE, Canada. Electronic address:

Microencapsulation of living cells is a field that has been heavily investigated by many researchers over the past two decades. Numerous experimental setups have been developed to encapsulate living cells in microbeads using different microfluidic devices and materials. Previous studies have investigated different microfluidic devices and materials for use in cancer treatment, drug delivery, environmental remediation, food production, and cell culture contexts. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.056DOI Listing
April 2019
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Achieving high gating performance for ion mobility spectrometry by manipulating ion swarm spatiotemporal behaviors in the vicinity of ion shutter.

Anal Chim Acta 2019 Apr 23;1052:96-104. Epub 2018 Nov 23.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, People's Republic of China. Electronic address:

Ion shutter is one of the key components of the drift-tube types of ion mobility spectrometer, which affects both the resolving power and sensitivity of an ion mobility spectrometer. In this work, a spatiotemporal model was built to understand the behaviors of the ion swarms around the ion shutter. For simplicity, a Tyndall-Powell gate (TPG) was chosen as the gating disturbance to the field on the two sides of ion shutter could be separated. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.045DOI Listing

Profiling and comparison of toxicant metabolites in hair and urine using a mass spectrometry-based metabolomic data processing method.

Anal Chim Acta 2019 Apr 13;1052:84-95. Epub 2018 Nov 13.

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 704, Taiwan. Electronic address:

Urine and hair are used for assessing human exposure to toxicants. Urine tests can show acute toxicant exposure. Hair analysis can be used to determine chronic toxicant exposure after months to years; however, compared to urine, hair analysis in exposure assessments is much less frequently investigated. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.009DOI Listing
April 2019
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Amphetamine-type stimulants analysis in oral fluid based on molecularly imprinting extraction.

Anal Chim Acta 2019 Apr 24;1052:73-83. Epub 2018 Nov 24.

Department of Analytical Chemistry, University of Valencia, 50th Dr. Moliner St., 46100, Burjassot, Spain. Electronic address:

A methamphetamine-based molecularly imprinted polymer (MIP) has been prepared by bulk polymerization to recognize new psychoactive substances (NPS) of the amphetamine, cathinones and 2C families in oral fluid samples, being the first precedent of a synthetized MIP for the extraction and preconcentration 32 NPS including amphetamine type substances and synthetic cathinones from oral fluids. Pre-polymerization complex and resulting materials were appropriately characterized by infrared spectroscopy, scanning electron microscopy, and nitrogen adsorption-desorption isotherms. Appropriateness of the material for the specific recognition of the target analytes was also evaluated through computational calculations and experimentally assessed by solid phase extraction (SPE). Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.046DOI Listing
April 2019
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Development of cerium oxide-based diffusive gradients in thin films technique for in-situ measurement of dissolved inorganic arsenic in waters.

Anal Chim Acta 2019 Apr 13;1052:65-72. Epub 2018 Nov 13.

Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.

A diffusive gradients in thin films (DGT) method using a new high-capacity cerium oxide (CeO) binding gel, for the first time, was developed for measuring dissolved inorganic arsenic in freshwater and seawater. The capacities of the new CeO binding gel were 682 μg and 375 μg for As and As, respectively. The masses of As and As accumulated by CeO-DGT device increased linearly with time and agreed well with the theoretical value calculated by DGT equation. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.023DOI Listing
April 2019
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Towards improving the electroanalytical speciation analysis of indium.

Anal Chim Acta 2019 Apr 10;1052:57-64. Epub 2018 Dec 10.

CNRS, LIEC (Laboratoire Interdisciplinaire des Environnements Continentaux), UMR7360, Vandoeuvre-lès-Nancy, F54501, France; Université de Lorraine, LIEC, UMR7360, Vandoeuvre-lès-Nancy, F54501, France.

The geochemical fate of indium in natural waters is still poorly understood, while recent studies have pointed out a growing input of this trivalent element in the environment as a result of its utilisation in the manufacturing of high-technology products. Reliable and easy-handling analytical tools for indium speciation analysis are, then, required. In this work, we report the possibility of measuring the total and free indium concentrations in solution using two complementary electroanalytical techniques, SCP (Stripping chronopotentiometry) and AGNES (Absence of Gradients and Nernstian Equilibrium Stripping) implemented with the TMF/RDE (Thin Mercury Film/Rotating Disk Electrode). Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.061DOI Listing
April 2019
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Etching reaction-based photoelectrochemical immunoassay of aflatoxin B in foodstuff using cobalt oxyhydroxide nanosheets-coating cadmium sulfide nanoparticles as the signal tags.

Anal Chim Acta 2019 Apr 7;1052:49-56. Epub 2018 Dec 7.

College of Biological Sciences and Engineering & Key Laboratory for Analytic Science of Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou, 350116, PR China. Electronic address:

A new split-type photoelectrochemical (PEC) immunosensing platform was designed for sensitive detection of aflatoxin B (AFB) in foodstuffs, coupling with enzymatic hydrolysate-triggered etching reaction of cobalt oxyhydroxide (CoOOH) on cadmium sulfide (CdS) nanoparticles-functionalized interface. Initially, the photosensitive electrode was prepared by coating CoOOH nanosheets on the surface of CdS nanoparticles to quench the photocurrent. Thereafter, a competitive-type enzyme immunoreaction was carried out on monoclonal anti-AFB antibody-conjugated magnetic bead by using alkaline phosphatase (ALP)-labeled bovine serum albumin-AFB (AFB-BSA) conjugate as the competitor. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.059DOI Listing
April 2019
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Non-invasive prediction of blood glucose trends during hypoglycemia.

Anal Chim Acta 2019 Apr 15;1052:37-48. Epub 2018 Dec 15.

Department of Clinical and Biomedical Engineering, Oslo University Hospital, Oslo, Norway; Department of Physics, University of Oslo, Oslo, Norway.

Over the last four decades, there has been a pursuit for a non-invasive solution for glucose measurement, but there is not yet any viable product released. Of the many sensor modalities tried, the combination of electrical and optical measurement is among the most promising for continuous measurements. Although non-invasive prediction of exact glucose levels may seem futile, prediction of their trends may be useful for certain applications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183144
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http://dx.doi.org/10.1016/j.aca.2018.12.009DOI Listing
April 2019
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Effect of image processing constraints on the extent of rotational ambiguity in MCR-ALS of hyperspectral images.

Anal Chim Acta 2019 Apr 6;1052:27-36. Epub 2018 Dec 6.

Université de Lille, LASIR CNRS, 59655, Lille, France. Electronic address:

Hyperspectral imaging is a way to explore the spatial and spectral information of the different compounds in chemical or biological samples. In addition, multivariate curve resolution - alternating least squares (MCR-ALS) can be used to extract this information based on the bilinearity assumption. However, it is well-known that using proper constraints can reduce the amount of uncertainty in the results of MCR, which is called rotational ambiguity. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.054DOI Listing

Odorants quantitation in high-quality cocoa by multiple headspace solid phase micro-extraction: Adoption of FID-predicted response factors to extend method capabilities and information potential.

Anal Chim Acta 2019 Apr 24;1052:190-201. Epub 2018 Nov 24.

Analytical Innovation, Corporate R&D Division, Firmenich S.A, Geneva, Switzerland.

This paper focuses on several methodological aspects in the quantitation of volatiles in solid samples by headspace solid phase micro-extraction (HS-SPME) combined with gas chromatography and parallel detection by flame ionization detector and mass spectrometry (GC-FID/MS). Informative volatiles, including key odorants and process markers, from single-origin cocoa samples (Colombia, Ecuador, Mexico, Sao Tomè, and Venezuela) were captured at two processing stages along the chocolate production chain (nibs and cocoa mass). Accurate quantitation was achieved by multiple headspace extraction (MHE) in headspace linearity conditions and by external calibration. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.043DOI Listing
April 2019
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Fingerprinting of traditionally produced red wines using liquid chromatography combined with drift tube ion mobility-mass spectrometry.

Anal Chim Acta 2019 Apr 23;1052:179-189. Epub 2018 Nov 23.

Division of Analytical Chemistry, Department of Chemistry, University of Natural Resources and Life Sciences (BOKU), Muthgasse 18, 1190, Vienna, Austria.

The characterization of wine via MS-based metabolic fingerprinting techniques remains a challenging undertaking due to the large number of phenolic compounds that cannot be confidently annotated and identified within analytical workflows. The combination of high performance liquid chromatography with low-field drift tube ion mobility time-of-flight mass spectrometry (HPLC × IMS-TOFMS) offers potential for the confident characterization and fingerprinting of wine using a metabolomics-type workflow. In particular, the use of collision cross section values from low-field drift tube IMS using nitrogen as drift gas (CCS) in addition to retention time and a high resolution mass spectrum for putative compounds allows rugged statistical assessment and identity confirmation using CCS libraries (<0. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.040DOI Listing
April 2019
3 Reads