212 results match your criteria Analytica Chimica Acta[Journal]
J Comp Eff Res 2018 Dec 4. Epub 2018 Dec 4.
Department of Urology, Mount Sinai Hospital, 625 Madison Avenue, New York, NY, 10022, USA.
Aim: To assess the cost-effectiveness of onabotulinumtoxinA (onabotA), implantable sacral nerve stimulation devices, percutaneous tibial nerve stimulation, anticholinergic medications and mirabegron compared with best supportive care (BSC) for management of refractory overactive bladder (OAB).
Methods: A Markov model was developed to compare the cost-effectiveness of treatment options with BSC over a 10-year time horizon. Resource utilization, discontinuation rates and costs were derived from unpublished and published sources. Read More
Eur J Haematol 2018 Nov 12. Epub 2018 Nov 12.
Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Objective: Adenovirus (AdV) infections are potentially life-threatening for allogeneic hematopoietic cell transplant (allo-HCT) recipients. The AdVance study aimed to evaluate the incidence management and outcomes of AdV infections in European allo-HCT recipients.
Methods: As part of the study physician surveys were conducted to determine current AdV screening and treatment practices at their center. Read More
Crit Rev Oncol Hematol 2018 Oct 24. Epub 2018 Oct 24.
Ipsen Pharma SAS, 65 quai Georges Gorse, Boulogne-Billancourt, Ile-de-France, France. Electronic address:
Background: Nivolumab and cabozantinib, two new treatment options for previously-treated advanced/metastatic renal cell carcinoma (aRCC), have recently been approved.
Methods: Two independent reviewers performed study selection, data extraction, and risk of bias assessment. Indirect treatment comparisons were carried out by directly assessing HR differences and statistical modeling of Kaplan-Meier curves from these two trials. Read More
Respir Med 2018 Nov 2;144:42-49. Epub 2018 Oct 2.
Bichat Hospital, AP-HP, Inserm U1152 & Paris-Diderot Medical School, 46 Rue Henri Huchard, 75877, Paris, France.
Objective: To describe the clinical and economic burden of severe asthma in France over 12 months.
Methods: Data were retrieved from the observational, prospective "Cohorte Obstruction Bronchique et Asthme" (COBRA) cohort, which has enrolled nearly 1000 asthma patients since 2007 from throughout France. Patients undergoing treatment with GINA step-4 or 5 medications uninterruptedly for 12 months (thus defining "severe asthma") were identified and their clinical data used to describe the clinical burden of asthma (exacerbations, symptoms outside exacerbations, and level of asthma control). Read More
Epidemiology 2019 Jan;30(1):61-68
From the Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
Background: The synthetic control model is a powerful tool to quantify the population-level impact of vaccines because it can adjust for trends unrelated to vaccination using a composite of control diseases. Because vaccine impact studies are often conducted using smaller, subnational datasets, we evaluated the performance of synthetic control models with sparse time series data. To obtain more robust estimates of vaccine impacts from noisy time series, we proposed a possible alternative approach, STL+PCA method (seasonal-trend decomposition plus principal component analysis), which first extracts smoothed trends from the control time series and uses them to adjust the outcome. Read More
Arch Toxicol 2018 Oct 8. Epub 2018 Oct 8.
European Food Safety Authority, Parma, Italy.
Quantifying differences in pharmacokinetics (PK) and toxicokinetics (TK) provides a science-based approach to refine uncertainty factors (UFs) for chemical risk assessment. Cytochrome P450 (CYP) 3A4-the major hepatic and intestinal human CYP-and the P-glycoprotein (Pgp) transporter share a vast range of common substrates for which PK may be modulated through inhibition or induction in the presence of grapefruit juice (GFJ) or St. John's wort (SJW), respectively. Read More
J Agric Food Chem 2018 Oct 16;66(43):11355-11361. Epub 2018 Oct 16.
University of Illinois College of Pharmacy, 833 South Wood Street , Chicago , Illinois 60612 , United States.
Although procyanidins constitute a unique class of polymeric plant secondary metabolites with a variety of biological properties including potent antioxidant activity, structure determination has been challenging, and structures of many complex procyanidins remain uncertain. To expedite the characterization of procyanidins, negative ion matrix-assisted laser desorption ionization high-energy collision-induced dissociation tandem time-of-flight (MALDI-ToF/ToF) mass spectra of 20 isolated procyanidins containing catechin and epicatechin subunits with degrees of polymerization up to five were obtained and evaluated. Structurally significant fragmentation pathways of singly charged, deprotonated molecules were identified representing quinone methide, heterocyclic ring fission, and retro-Diels-Alder fragmentation. Read More
J Anal Toxicol 2018 Oct 1. Epub 2018 Oct 1.
CSIC, Instituto de Carboquímica, Miguel Luesma Castán 4., Zaragoza, Spain.
In this study, we describe the transfer of a new and fully automated workflow for the cost-effective drug screening of large populations based on the dried blood spot (DBS) technology. The method was installed at a routine poison control center and applied for DBS and dried urine spot (DUS) samples. A fast method focusing on the high-interest drugs and an extended screening method were developed on the automated platform. Read More
Sci Total Environ 2019 Feb 15;651(Pt 1):516-531. Epub 2018 Sep 15.
Institut National de l'Environnement Industriel et des Risques (INERIS), Models for Ecotoxicology and Toxicology Unit, Parc ALATA, BP2, 60550 Verneuil-en-Halatte, France; Institut National de l'Environnement Industriel et des Risques (INERIS), UMR-I 02 SEBIO, Parc ALATA, BP2, 60550 Verneuil-en-Halatte, France. Electronic address:
One of the goals of environmental risk assessment is to protect the whole ecosystem from adverse effects resulting from exposure to chemicals. Many research efforts have aimed to improve the quantification of dose-response relationships through the integration of toxicokinetics. For this purpose, physiologically-based toxicokinetic (PBTK) models have been developed to estimate internal doses from external doses in a time-dependent manner. Read More
J Am Board Fam Med 2018 Sep-Oct;31(5):743-751
From School of Public Health, The University of Memphis, Memphis, TN (SSB, OOI, SK); School of Pharmacy, University of Wisconsin, Madison, WI (OS); Department of Nursing, University of South Dakota, Sioux Falls, SD (PD); Analytica Laser, New York, NY (AC); Department of Health Systems Administration, Georgetown University, Washington D.C. (SH); Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, WI (YW); Health Research and Educational Trust, Chicago, IL (JB); Department of Health Administration, Governor State University, IL (LN); Department of Clinical Pharmacy, University of Tennessee Health Sciences Center, TN (WJL); Jack C. Massey College of Business, Belmont University, TN (DW); Fogelman College of Business and Economics, The University of Memphis, Memphis, TN (CFC).
Objective: Under 50% of type 2 diabetic patients achieve the recommended glycemic control. One barrier to glycemic control is patients' cost-related nonadherence to medications. We hypothesize gender differences in medication nonadherence due to costs among diabetic patients. Read More
Nanomaterials (Basel) 2018 Aug 18;8(8). Epub 2018 Aug 18.
Research Center for Advanced Chemical Analysis, Instrumentation and Chemometrics (ANALYTICA), Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany Janos Street, Cluj-Napoca 400028, Romania.
The present study reports for the first time the efficacy of bioactive compounds from L. fruit extract as reducing and capping agents of silver nanoparticles (AgNPs), developing a green, zero energetic, cost effective and simple synthesis method of AgNPs. The obtained nanoparticles were characterized by UV-Vis spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier Transform Infrared spectroscopy (FTIR), confirming that nanoparticles were crystalline in nature, spherical in shape, with an average size of 7 nm. Read More
Anal Chim Acta 2018 11 7;1031:195. Epub 2018 Jun 7.
Department of Analytical Chemistry, Institute of Chemistry - UNICAMP, P.O. Box 6154, 13083-970, Campinas, SP, Brazil. Electronic address:
The purpose of this Corrigendum is to cite and comment on an important reference that brings some support to the ideas developed in this paper and should be chronologically inserted into the history of advances in this area. Read More
Lancet Glob Health 2018 Sep;6(9):e956-e957
Sage Analytica, Maine, MD, USA.
Obstet Gynecol 2018 Aug;132(2):261-270
Department of Microbiology Infectious Diseases, the Royal Women's Hospital, Department of Microbiology, the Royal Children's Hospital, Infection and Immunity, Murdoch Children's Research Institute, Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia; the Department of Gynecology and Obstetrics, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; the Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas; Institut Catala d'Oncologia, IDIBELL, CIBER-ESP, RTICC, L'Hospitalet de Llobregat, Barcelona, Spain; the Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; the Department of Pathology, SMBD Jewish General Hospital and McGill University, Montréal, Québec, Canada; the Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia; the Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida; the National Institute of Public Health, Cuernavaca, Morelos, Mexico; the Division of Gynecologic Oncology, University of Alabama, Birmingham, Alabama; the Department of Clinical Science, University of Bergen/Haukeland University Hospital, Bergen, Norway; the Danish Cancer Society Research Center, Copenhagen, Denmark and Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Johns Hopkins University School of Medicine, Baltimore, Maryland; the Department of Obstetrics and Gynecology, Clinica Colsanitas, Fundacion Universitaria Sanitas, Bogota, Colombia; Institut du col, Paris, France; the National Institute of Cancer, Bogotá, Colombia; the Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland; the Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Direction des Risques Biologiques et de la Santé au Travail, Institut National de Santé Publique du Québec, Montréal, Québec, Canada; Robert E. Fechner Laboratory of Surgical Pathology, University of Virginia Health System, Charlottesville, Virginia; the Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico; UCLA School of Nursing, Los Angeles, California; Merck & Co, Inc., Kenilworth, New Jersey; Universidad del Rosario, Bogota, Colombia; and Analytica LASÉR, Montréal, Québec, Canada.
Objective: To estimate the proportion of vulvar and vaginal low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) in females 15-26 years of age attributable to 14 human papillomavirus (HPV) genotypes (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59).
Methods: A post hoc analysis of prospectively diagnosed vulvar and vaginal LSILs and HSILs among females 15-26 years of age enrolled in the placebo arms of two phase 3, randomized HPV vaccine trials assessed 14 prespecified HPV genotypes associated with cervical cancers or anogenital warts using a type-specific multiplex polymerase chain reaction assay. The frequency of lesions associated with specific HPV genotypes was estimated by proportional and other attribution methods. Read More
Adv Ther 2018 Jul 9. Epub 2018 Jul 9.
Department of Medical Oncology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Introduction: Unresectable, well-differentiated nonfunctioning gastroenteropancreatic neuroendocrine tumors (GEP-NETs) can be monitored (watchful waiting, WW) or treated with systemic therapy such as somatostatin analogues (SSAs) to delay progression. We applied a reflective multicriteria decision analysis (MCDA) shared-decision framework (previously developed for the USA) to explore what matters to Spanish patients and clinicians considering GEP-NET treatment options.
Methods: The EVIDEM-derived framework was updated and adapted to the Spanish context. Read More
BMC Med Res Methodol 2018 Jul 6;18(1):75. Epub 2018 Jul 6.
LASER Core, Paris, France.
Background: Phase III randomized controlled trials (RCT) typically exclude certain patient subgroups, thereby potentially jeopardizing estimation of a drug's effects when prescribed to wider populations and under routine care ("effectiveness"). Conversely, enrolling heterogeneous populations in RCTs can increase endpoint variability and compromise detection of a drug's effect. We developed the "RCT augmentation" method to quantitatively support RCT design in the identification of exclusion criteria to relax to address both of these considerations. Read More
EMBO Rep 2018 Aug 2;19(8). Epub 2018 Jul 2.
Institute for Biomedical Ethics, University of Basel, Basel, Switzerland.
J Rural Health 2018 Jun 10. Epub 2018 Jun 10.
Department of Environmental and Occupational Health, School of Community Health Sciences, University of Nevada, Las Vegas, Nevada.
Purpose: The purpose of this study was to examine rural-urban differences in access to breast cancer screening in a predominantly rural Midwestern state in the United States.
Methods: The study is a retrospective analysis of pooled cross-sectional data for the years 2008 to 2012. We conducted hot spot analyses of the rate of late-stage diagnosis of breast cancer at the census tract level in Nebraska for cases diagnosed between 2008 and 2012, using cancer registry data. Read More
ACS Appl Mater Interfaces 2018 Jun 14;10(25):21730-21739. Epub 2018 Jun 14.
SSAB Europe Oy , Harvialantie 420 , FI-13300 Hämeenlinna , Finland.
Zinc carbonate and a mixed-phase zinc carbonate were precipitated selectively on hot dip galvanized steel in the presence of CO and water. The zinc carbonate was precipitated as a uniform layer with cubic superficial appearance, while the mixed-phase zinc carbonate was precipitated as nanowires. The distinct structures could be formed separately or as a dual structure with nanowires on the outermost surface. Read More
Clin Infect Dis 2018 Jul;67(3):341-349
Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Denmark.
Background: Early clinical severity assessments during the 2009 influenza A H1N1 pandemic (pH1N1) overestimated clinical severity due to selection bias and other factors. We retrospectively investigated how to use data from the International Network for Strategic Initiatives in Global HIV Trials, a global clinical influenza research network, to make more accurate case fatality ratio (CFR) estimates early in a future pandemic, an essential part of pandemic response.
Methods: We estimated the CFR of medically attended influenza (CFRMA) as the product of probability of hospitalization given confirmed outpatient influenza and the probability of death given hospitalization with confirmed influenza for the pandemic (2009-2011) and post-pandemic (2012-2015) periods. Read More
Med Arch 2018 Apr;72(2):94-98
Clinic for Heart, Blood Vessel and Rheumatic Diseases. University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Introduction: Ischemic heart disease (IHD) is clinical manifestation of chronic inflammatory progressive pathological process of atherosclerosis in coronary arteries. IHD is the leading cause of morbidity and mortality in the world. The question is whether it is possible to improve and direct the therapeutic treatment of IHD patients in the treatment of the inflammatory process in the atherosclerotic leasions. Read More
Soc Stud Sci 2018 Apr;48(2):204-231
Department of Sociology, Dartmouth College, Hanover, NH, USA.
Recent public controversies, ranging from the 2014 Facebook 'emotional contagion' study to psychographic data profiling by Cambridge Analytica in the 2016 American presidential election, Brexit referendum and elsewhere, signal watershed moments in which the intersecting trajectories of psychology and computer science have become matters of public concern. The entangled history of these two fields grounds the application of applied psychological techniques to digital technologies, and an investment in applying calculability to human subjectivity. Today, a quantifiable psychological subject position has been translated, via 'big data' sets and algorithmic analysis, into a model subject amenable to classification through digital media platforms. Read More
Clinicoecon Outcomes Res 2018 23;10:243-250. Epub 2018 Apr 23.
Ipsen Pharma, Boulogne-Billancourt, France.
Purpose: The aim of this study was to compare the cost-effectiveness of cabozantinib with the standard of care in England in adult patients with advanced renal cell carcinoma (aRCC), following prior vascular endothelial growth factor receptor (VEGFR)-targeted therapy.
Methods: We developed a partitioned-survival model with three health states to assess the cost-effectiveness of cabozantinib and its comparators. The model time horizon was 30 years. Read More
J AOAC Int 2018 Nov 4;101(6):1857-1863. Epub 2018 Apr 4.
U.S. Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH.
In the last several years, economically motivated adulteration (EMA) of foods including honey has received increased attention. The addition of inexpensive sweeteners such as high fructose corn syrup or cane sugar to honey is still encountered despite scientific methods that can routinely detect this type of adulteration. The standard method for detection of these adulterants utilizes isotope ratio mass spectrometry (IRMS); however, this technique requires an elevated degree of technical knowledge for operation as well as a high cost for purchase and maintenance. Read More
Nature 2018 03;555(7698):559-560
Heart 2018 Oct 13;104(19):1583-1592. Epub 2018 Mar 13.
Pharmacoepidemiology, Analytica LA-SER, London, UK.
Objective: To compare ticagrelor and prasugrel with clopidogrel for recurrent fatal and non-fatal myocardial infarction (reMI) in real-life conditions.
Methods: Case-referent study using the Pharmacoepidemiological General Research eXtension (PGRx)-acute coronary syndrome (ACS) registry. Cases were patients with reMI from a cohort with index ACS or external to the cohort (same sites). Read More
PLoS One 2018 6;13(3):e0192587. Epub 2018 Mar 6.
Department of Cardiology, Kepler University Hospital, Linz, Austria.
Introduction: Intra-operative complications like mechanical damages to the leads, infections and hematomas during generator replacements of implantable pacemakers and defibrillators contribute to additional costs for hospitals. The aim of this study was to evaluate operation room use, costs and budget impact of generator replacements using either a traditional surgical intervention (TSI) with scissors, scalpel and electrocautery vs. a new radiofrequency energy based surgical system, called PEAK PlasmaBladeTM (PPB). Read More
Curr Oncol 2018 Feb 28;25(1):32-40. Epub 2018 Feb 28.
Novartis Pharmaceuticals Corporation, Dorval, QC.
Background: In 2016, everolimus was approved by Health Canada for the treatment of unresectable, locally advanced or metastatic, well-differentiated, non-functional, neuroendocrine tumours (NET) of gastrointestinal (GI) or lung origin in adult patients with progressive disease. This analysis evaluated the cost-effectiveness of everolimus in this setting from a Canadian societal perspective.
Methods: A partitioned survival model was developed to compare the cost per life-year (LY) gained and cost per quality-adjusted life-year (QALY) gained of everolimus plus best supportive care (BSC) versus BSC alone in patients with advanced or metastatic NET of GI or lung origin. Read More
Target Oncol 2018 Apr;13(2):205-216
IPSEN Pharma SAS, Boulogne-Billancourt Cedex, France.
Background: Cabozantinib has recently been evaluated as a first-line treatment in advanced renal cell carcinoma (aRCC).
Objective: To indirectly assess efficacy of cabozantinib versus standard-of-care (SoC) comparators in the first-line treatment of aRCC.
Methods: We conducted a systematic literature review (SLR) to identify randomized controlled studies in the first-line setting for aRCC. Read More
Clin Epidemiol 2017 14;9:689-698. Epub 2017 Dec 14.
Farr Institute, University of Manchester, Manchester, UK.
Purpose: A case study was conducted, exploring methods to identify drugs effects modifiers, at a health care center level.
Patients And Methods: Data were drawn from the Schizophrenia Outpatient Health Outcome cohort, including hierarchical information on 6641 patients, recruited from 899 health care centers from across ten European countries. Center-level characteristics included the following: psychiatrist's gender, age, length of practice experience, practice setting and type, countries' Healthcare System Efficiency score, and psychiatrist density in the country. Read More
Adv Ther 2018 Jan 21;35(1):81-99. Epub 2017 Dec 21.
Analytica Laser, Montreal, Canada.
Introduction: Well- or moderately differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are often slow-growing, and some patients with unresectable, asymptomatic, non-functioning tumors may face the choice between watchful waiting (WW), or somatostatin analogues (SSA) to delay progression. We developed a comprehensive multi-criteria decision analysis (MCDA) framework to help patients and physicians clarify their values and preferences, consider each decision criterion, and support communication and shared decision-making.
Methods: The framework was adapted from a generic MCDA framework (EVIDEM) with patient and clinician input. Read More
PLoS One 2017 15;12(12):e0186739. Epub 2017 Dec 15.
LASER Analytica, London, United Kingdom.
Introduction: During the 2013-2014 influenza season, Public Health England extended routine influenza vaccination to all 2- and 3-year-old children in England. To estimate the impact of this change in policy on influenza-related morbidity and mortality, we developed a disease transmission and surveillance model informed by real-world data.
Methods: We combined real-world and literature data sources to construct a model of influenza transmission and surveillance in England. Read More
Hum Vaccin Immunother 2018 02 19;14(2):368-377. Epub 2017 Dec 19.
f Formerly of LASER Analytica , London , UK.
This study set out to evaluate influenza- and respiratory-related illnesses recorded during primary care physician consultations in England following the H1N1 pandemic in 2009 and to enable the development of a dynamic disease model. Data were obtained from the Clinical Practice Research Datalink of primary care records over four influenza seasons (2010-2014). The primary outcome of the study was incidence of influenza- and respiratory-related diagnoses, calculated per practice and by season and age group. Read More
Clin Infect Dis 2017 Nov;65(11):1813-1818
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut.
Background: Pneumococcal conjugate vaccines (PCVs) are being used worldwide. A key question is whether the impact of PCVs on pneumonia is similar in low- and high-income populations. However, most low-income countries, where the burden of disease is greatest, lack reliable data that can be used to evaluate the impact. Read More
BMC Infect Dis 2017 09 25;17(1):642. Epub 2017 Sep 25.
Netherlands Institute for Health Services Research (NIVEL), Utrecht, The Netherlands.
Background: A global pandemic mortality study found prominent regional mortality variations in 2009 for Influenza A(H1N1)pdm09. Our study attempts to identify factors that explain why the pandemic mortality burden was high in some countries and low in others.
Methods: As a starting point, we identified possible risk factors worth investigating for Influenza A(H1N1)pdm09 mortality through a targeted literature search. Read More
PLoS One 2017 8;12(9):e0184423. Epub 2017 Sep 8.
Decision Analytics and Value in Access, Analytica LA-SER, London, England.
Background: Relative effect of therapies indicated for the treatment of advanced renal cell carcinoma (aRCC) after failure of first line treatment is currently not known. The objective of the present study is to evaluate progression-free survival (PFS) and overall survival (OS) of cabozantinib compared to everolimus, nivolumab, axitinib, sorafenib, and best supportive care (BSC) in aRCC patients who progressed after previous VEGFR tyrosine-kinase inhibitor (TKI) treatment.
Methodology & Findings: Systematic literature search identified 5 studies for inclusion in this analysis. Read More
Epidemiology 2017 11;28(6):889-897
From the aDepartment of Statistics, University of California, Riverside, CA; bDepartment of Biostatistics, Yale School of Public Health, New Haven, CT; cSage Analytica, Bethesda, MD; dDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT; eDpto. de Epidemiología, DIPLAS, Ministerio de Salud, Chile; and fDepartment of Global Health, Milken Institute School of Public Health, George Washington University, Washington, DC.
Background: Pneumococcal conjugate vaccines (PCVs) prevent invasive pneumococcal disease and pneumonia. However, some low-and middle-income countries have yet to introduce PCV into their immunization programs due, in part, to lack of certainty about the potential impact. Assessing PCV benefits is challenging because specific data on pneumococcal disease are often lacking, and it can be difficult to separate the effects of factors other than the vaccine that could also affect pneumococcal disease rates. Read More
Schizophr Res 2018 03 13;193:146-153. Epub 2017 Jul 13.
LASER Analytica, 3 rue de l'Arrivée, 75015 Paris.
Objectives: To explore the impact upon estimation of drug effect as a result of applying exclusion criteria in randomized-controlled trials (RCT) measuring the efficacy of antipsychotics (AP) in schizophrenia.
Methods: Three characteristics which may act as effect-modifiers of AP, while also common exclusion criteria in RCTs, were identified through literature review: schizophrenia duration, substance use disorder and poor adherence. The SOHO cohort was used to estimate the effect of initiating antipsychotic drugs "A", "B" or "C" (pooled) upon symptom evolution at 3months from baseline (CGI-S scale). Read More
Nanomaterials (Basel) 2017 Jul 11;7(7). Epub 2017 Jul 11.
Laboratory of Materials Science, Tampere University of Technology, P.O. Box 589, FI-33101 Tampere, Finland.
In this study, we demonstrate a rapid treatment method for producing a needle-like nanowire structure on a hot-dip galvanized sheet at a temperature of 50 °C. The processing method involved only supercritical carbon dioxide and water to induce a reaction on the zinc surface, which resulted in growth of zinc hydroxycarbonate nanowires into flower-like shapes. This artificial patina nanostructure predicts high surface area and offers interesting opportunities for its use in industrial high-end applications. Read More
J Popul Ther Clin Pharmacol 2017 May 30;24(2):e61-e70. Epub 2017 May 30.
Analytica LASER, Paris, France.
Background: Long-acting injectable (LAI) atypical antipsychotics are associated with improved adherence and reduced relapse rates in schizophrenia but reminder-based interventions may further improve outcomes.
Objectives: To assess an institutional medication adherence program's (IMAP) effectiveness on adherence and psychiatric hospitalizations among schizophrenia patients taking risperidone LAI (RLAI).
Methods: Between 2009 and 2010, we recruited patients meeting DSM-IV criteria for schizophrenia treated with RLAI receiving outpatient care from psychiatric centres in France. Read More
Int J STD AIDS 2017 12 5;28(14):1405-1409. Epub 2017 Jun 5.
1 SE 'Institute of Dermatology and Venerology of the National Academy of Medical Sciences of Ukraine,' Kharkiv, Ukraine.
There are no accurate data regarding the prevalence of Chlamydia trachomatis infection in Ukraine. This study aims to estimate the prevalence in the northeastern region of the country through reviewing nucleic acid amplification test results in patients of medical institutions in the Kharkov region during 2014-2016. Samples from 6920 patients (5028 women and 1892 men) aged 12-76 years were tested. Read More
Anal Chim Acta 2017 06 10;972:12-15. Epub 2017 Apr 10.
Elemental Bio-imaging Facility, University of Technology Sydney, Broadway, New South Wales 2007, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address:
Int J Technol Assess Health Care 2017 Jan 24;33(1):111-120. Epub 2017 Apr 24.
Objectives: The aim of this study was to adapt and assess the value of a Multi-Criteria Decision Analysis (MCDA) framework (EVIDEM) for the evaluation of Orphan drugs in Catalonia (Catalan Health Service).
Methods: The standard evaluation and decision-making procedures of CatSalut were compared with the EVIDEM methodology and contents. The EVIDEM framework was adapted to the Catalan context, focusing on the evaluation of Orphan drugs (PASFTAC program), during a Workshop with sixteen PASFTAC members. Read More
BMC Cancer 2017 04 17;17(1):272. Epub 2017 Apr 17.
LASER Analytica, Montreal, Quebec, Canada.
Background: The objective of the study was to reveal through pragmatic MCDA (EVIDEM) the contribution of a broad range of criteria to the value of the orphan drug lenvatinib for radioiodine refractory differentiated thyroid cancer (RR-DTC) in country-specific contexts.
Methods: The study was designed to enable comprehensive appraisal (12 quantitative, 7 qualitative criteria) in the current disease context (watchful waiting, sorafenib) of France, Italy and Spain. Data on the value of lenvatinib was collected from diverse stakeholders during country-specific panels and included: criteria weights (individual and social values); performance scores (judgments on evidence-collected through MCDA systematic review); qualitative impacts of contextual criteria; and verbal and written insights structured by criteria. Read More
J Manag Care Spec Pharm 2017 Apr;23(4):446-452
4 Sanofi, Chilly-Mazarin Cedex, France.
Background: Type 2 diabetes mellitus (T2DM) results in a substantial economic burden on patients, health care systems, and society. Most literature assessing the cost of T2DM focuses on the long-term complications of the disease, the association between glucose control and cost, and patient characteristics resulting in poor and costly outcomes. However, it is likely that attributes specific to diabetes therapy can affect the use of costly resources. Read More
Pharmacoeconomics 2017 May;35(5):605-606
LASER Analytica, 3100 Côte-Vertu Boulevard, Suite 230, St-Laurent, QC, H4R 2J8, Canada.
BMC Public Health 2017 03 21;17(1):271. Epub 2017 Mar 21.
GSK, King of Prussia, USA.
Background: Estimates of influenza and respiratory syncytial virus (RSV) burden must be periodically updated to inform public health strategies. We estimated seasonal influenza- and RSV-attributable hospitalizations in the US from 1997 to 2009 according to age and risk status (NCT01599390).
Methods: Multiple linear regression modelling was used to attribute hospitalizations to influenza or RSV using virological surveillance and hospitalization data. Read More
Neuropsychiatr Dis Treat 2017 28;13:621-630. Epub 2017 Feb 28.
National Centre for Register-based Research, Department of Economics and Business Economics, Aarhus BSS, Aarhus University, Aarhus; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.
Objective: Schizophrenia and/or antipsychotic drug use are associated with metabolic abnormalities; however, knowledge regarding metabolic status and physician's monitoring of metabolic status at first schizophrenia diagnosis is sparse. We assessed the prevalence of monitoring for metabolic blood abnormalities and characterized the metabolic profiles in people with a first-time schizophrenia diagnosis.
Methods: This is a population-based cross-sectional study including all adults born in Denmark after January 1, 1955, with their first schizophrenia diagnosis between 2000 and 2012 in the Central Denmark Region. Read More
J Nat Prod 2017 02 13;80(2):415-426. Epub 2017 Feb 13.
Planta Analytica LCC , 461 Danbury Road, New Milford, Connecticut 06776, United States.
Peanut skins are a rich source of oligomeric and polymeric procyanidins. The oligomeric fractions are dominated by dimers, trimers, and tetramers. A multistep chromatographic fractionation led to the isolation of four new A-type procyanidins of tri- and tetrameric structures. Read More
J Autoimmun 2017 May 9;79:84-90. Epub 2017 Feb 9.
LASER Europe Ltd, London, 66 Chiltern St, London W1U 4JT, United Kingdom; Department of Epidemiology, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK.
Background: Safety of HPV vaccines is still in question due to reports of autoimmune diseases (ADs) following HPV immunization.
Objectives: To assess the risk of ADs associated with HPV vaccination of female adolescents/young adults in France.
Methods: Systematic prospective case-referent study conducted to assess the risks associated with real-life use of HPV vaccines. Read More