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    8554 results match your criteria Analytica Chimica Acta[Journal]

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    Systematic approach in Mg(2+) ions analysis with a combination of tailored fluorophore design.
    Anal Chim Acta 2017 Oct 4;988:96-103. Epub 2017 Aug 4.
    Department of Chemical Science and Technologies, University of Rome "Tor Vergata", Rome, Italy; Laboratory of Artificial Sensory Systems, ITMO University, St. Petersburg, Russia.
    A systematic study of a series of diaza-18-crown-6 8-hydroxyquinoline (DCHQ) chemosensors, devoted to Mg(II) ion detection, was performed. Functionalization of DCHQ by peripheral substituents allowed the development of novel all-solid-state optodes via inclusion inside PVC-based polymeric films. The influence on the DCHQ-based optode response of the lipophilic sites functionalization and of the nature of the plasticizer, was investigated. Read More

    A Eu(III) doped metal-organic framework conjugated with fluorescein-labeled single-stranded DNA for detection of Cu(II) and sulfide.
    Anal Chim Acta 2017 Oct 4;988:89-95. Epub 2017 Aug 4.
    School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China. Electronic address:
    In this paper, Bio-MOF-1 is prepared as reported and then Eu(3+) is introduced into it via cation exchange method. A FAM-labeled ssDNA is chosen to fabricate with the obtained Eu(3+)@Bio-MOF-1. A luminescent hybrid material is assembled, which can exhibit the fluorescence of Eu(3+) and FAM simultaneously by adjusting the ratio of FAM-ssDNA and Eu(3+)@Bio-MOF-1. Read More

    Genetically functionalized ferritin nanoparticles with a high-affinity protein binder for immunoassay and imaging.
    Anal Chim Acta 2017 Oct 4;988:81-88. Epub 2017 Aug 4.
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, South Korea. Electronic address:
    Molecular detection of target molecules with high sensitivity and specificity is of great significance in bio and medical sciences. Here, we present genetically functionalized ferritin nanoparticles with a high-affinity protein binder, and their utility as a signal generator in a variety of immunoassays and imaging. As a high-affinity protein binder, human IgG-specific repebody, which is composed of LRR (Leucine-rich repeat) modules, was used. Read More

    Silver nanoclusters capped silica nanoparticles as a ratiometric photoluminescence nanosensor for the selective detection of I(-) and S(2).
    Anal Chim Acta 2017 Oct 29;988:74-80. Epub 2017 Jul 29.
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; University of the Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address:
    A novel and efficient approach has been established for the synthesis of silver nanoclusters capped silica nanoparticles (SiO2@AgNCs). These nanoclusters (AgNCs) capped silica nanoparticles were utilized as a novel ratiometric photoluminescence (PL) nanosensor for extremely sensitive and selective detection of I(-) and S(2-) ions. The AgNCs were prepared in situ on the silica nanoparticles through polyethyleneimine (PEI) template approach. Read More

    Selective imaging of cancer cells with a pH-activatable lysosome-targeting fluorescent probe.
    Anal Chim Acta 2017 Oct 31;988:66-73. Epub 2017 Jul 31.
    State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:
    Fluorescence imaging with tumor-specific fluorescent probe has emerged as a tool to aid surgeons in the identification and removal of tumor tissue. We report here a new lysosome-targeting fluorescent probe (NBOH) with BODIPY fluorephore to distinguish tumor tissue out of normal tissue based on different pH environment. The probe exhibited remarkable pH-dependent fluorescence behavior in a wide pH range from 3. Read More

    Highly selective and sensitive visualization and identification of glycoproteins using multi-functionalized soluble dendrimer.
    Anal Chim Acta 2017 Oct 11;988:58-65. Epub 2017 Aug 11.
    Dalian Medical University, Lvshun South Road No 9, Dalian, 116044, China. Electronic address:
    Glycoproteins are the most important and complex group of posttranslational modifications known in proteins. Many clinical biomarkers and therapeutic targets in cancer are glycoproteins. However, the isolation of glyco-specific antibodies and their poor stability remains a significant challenge in analytical method and diagnostic development. Read More

    Controlled, synchronized actuation of microdroplets by gravity in a superhydrophobic, 3D-printed device.
    Anal Chim Acta 2017 Oct 14;988:50-57. Epub 2017 Aug 14.
    Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario K7L 3N6, Canada. Electronic address:
    Droplet manipulation over open surfaces allows one to perform assays with a large degree of control and high throughput, making them appealing for applications in drug screening or (bio)analysis. However, the design, manufacturing and operation of these systems comes with high technical requirements. In this study we employ a commercial, low-friction, superhydrophobic coating, Ultra-Ever Dry(®), on a 3D-printed microfluidic device. Read More

    Identification of novel non-ionic, cationic, zwitterionic, and anionic polyfluoroalkyl substances using UPLC-TOF-MS(E) high-resolution parent ion search.
    Anal Chim Acta 2017 Oct 22;988:41-49. Epub 2017 Aug 22.
    Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58202-9037, United States.
    Poly- and perfluoroalkyl substances (poly- and per-PFASs) are a large group of organic compounds that have become the target of investigation due to their widespread occurrence in the environment and biota, coupled with their known or suspected impacts on human health. Recent studies have shown that a significant portion of poly-PFASs remain unidentified. This study presents a time-of-flight mass spectrometry approach based on continuously interleaving scans at low and high collision energies (ToF-MS(E)) for the rapid identification and characterization of unknown PFASs. Read More

    Improved analytical techniques of sulfur isotopic composition in nanomole quantities by MC-ICP-MS.
    Anal Chim Acta 2017 Oct 18;988:34-40. Epub 2017 Aug 18.
    Department of Geosciences, National Taiwan University, Taipei 10617, Taiwan, ROC.
    We propose an improved method for precise sulfur isotopic measurements by multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) in conjunction with a membrane desolvation nebulization system. The problems of sulfur loss through the membrane desolvation apparatus are carefully quantified and resolved. The method overcomes low intrinsic sulfur transmission through the instrument, which was initially 1% when operating at a desolvation temperature of 160 °C. Read More

    Improving wastewater-based epidemiology to estimate cannabis use: focus on the initial aspects of the analytical procedure.
    Anal Chim Acta 2017 Oct 18;988:27-33. Epub 2017 Aug 18.
    Research Institute for Pesticides and Water, University Jaume I, Avda. Sos Baynat s/n, E-12071, Castellón, Spain. Electronic address:
    Wastewater-based epidemiology is a promising and complementary tool for estimating drug use by the general population, based on the quantitative analysis of specific human metabolites of illicit drugs in urban wastewater. Cannabis is the most commonly used illicit drug and of high interest for epidemiologists. However, the inclusion of its main human urinary metabolite 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THC-COOH) in wastewater-based epidemiology has presented several challenges and concentrations seem to depend heavily on environmental factors, sample preparation and analyses, commonly resulting in an underestimation. Read More

    A modified DGT technique for the simultaneous measurement of dissolved inorganic nitrogen and phosphorus in freshwaters.
    Anal Chim Acta 2017 Oct 26;988:17-26. Epub 2017 Aug 26.
    Environmental Futures Research Institute, School of Environment, Griffith University, Gold Coast Campus, QLD 4215, Australia.
    A modified diffusive gradients in thin films (DGT) technique uses both a mixed binding layer (PrCH and A520E resins for NH4-N and NO3-N, respectively) and multiple binding layers (Metsorb binding layer for PO4-P overlying the mixed binding layer) for the simultaneous measurement of dissolved inorganic nitrogen (nitrate and ammonium) and phosphate in freshwater (INP-DGT). High uptake and elution efficiencies were determined for a mixed (PrCH/A520E) binding gel for dissolved inorganic nitrogen and an agarose-based Metsorb binding layer for PO4-P. Diffusion coefficients (D) obtained from DGT time-series experiments (conductivity 180 μS cm(-1)) for NH4-N, NO3-N and PO4-P agreed well with those measured using individual DGT techniques in previous studies, but were characterised over a wider range of ionic strengths here. Read More

    π-Extended triptycene-based material for capillary gas chromatographic separations.
    Anal Chim Acta 2017 Oct 4;988:121-129. Epub 2017 Aug 4.
    Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials and School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China. Electronic address:
    Triptycene-based materials feature favorable physicochemical properties and unique molecular recognition ability that offer good potential as stationary phases for capillary gas chromatography (GC). Herein, we report the investigation of utilizing a π-extended triptycene material (denoted as TQPP) for GC separations. As a result, the TQPP capillary column exhibited high column efficiency of 4030 plates m(-1) and high-resolution performance for a wide range of analytes, especially structural and positional isomers. Read More

    Determination of (99)Tc in fresh water using TRU resin by ICP-MS.
    Anal Chim Acta 2017 Oct 18;988:114-120. Epub 2017 Aug 18.
    Canadian Nuclear Laboratories (CNL), Radiological Protection Research and Instrumentation Branch, Chalk River, ON, K0J 1J0, Canada.
    Technetium-99 ((99)Tc) determination at trace level by inductively coupled plasma mass spectrometry (ICP-MS) is challenging because there is no readily available appropriate Tc isotopic tracer. A new method using Re as a recovery tracer to determine (99)Tc in fresh water samples, which does not require any evaporation step, was developed. Tc(VII) and Re(VII) were pre-concentrated on a small anion exchange resin (AER) cartridge from one litre of water sample. Read More

    The preparation of a poly (pentaerythritol tetraglycidyl ether-co-poly ethylene imine) organic monolithic capillary column and its application in hydrophilic interaction chromatography for polar molecules.
    Anal Chim Acta 2017 Oct 26;988:104-113. Epub 2017 Aug 26.
    Key Laboratory of Phytochemical R&D of Hunan Province, Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, China.
    An easy single-step thermal treatment "one-pot" approach for the preparation of poly (pentaerythritol tetraglycidyl ether-co-poly ethylene imine) organic monolithic capillary columns was developed successfully. The column was prepared by the epoxy-amine ring-opening polymerization of pentaerythritol tetraglycidyl ether (PTE) with poly (ethylene imine) (PEI) using acetonitrile (ACN) and polyethylene glycol 600 (PEG 600) as the porogenic system at 60 °C for 12 h. The obtained monolith was homogeneous and permeable. Read More

    Review: Novel sensing strategies for bacterial detection based on active and passive methods driven by external field.
    Anal Chim Acta 2017 Oct 21;988:1-16. Epub 2017 Jul 21.
    Department of Physical Science, Graduate School of Science, Osaka Prefecture University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan; Research Institute for Light-induced Acceleration System (RILACS), Osaka Prefecture University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan. Electronic address:
    For sustainable human life, biosensing systems for contaminants or disease-causing bacteria are crucial for food security, environmental improvement, and disease prevention. With an aim of enhancing the sensitivity and detection speed, many researchers have developed efficient detection methods for target bacteria. In this review, we discuss recent topics related to active and passive bacterial detection methods, including (1) optical approaches with unique functional nano- and micro-structures, and (2) electrical approaches involving mechanical modulation and electrochemical reactions. Read More

    Evaluation of fluorogenic substrates for Ni/Co LDHs peroxidase mimic and application for determination of inhibitory effects of antioxidant.
    Anal Chim Acta 2017 Sep 4;987:98-104. Epub 2017 Aug 4.
    Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, PR China; Henan Key Laboratory of Green Chemical Media and Reactions, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, PR China.
    Nanomaterial-based peroxidase-mimetics are an emerging research field that promises to produce alternatives to horseradish peroxidase for a variety of applications. Generally, some peroxidase-mimetics substrates are used in acidic condition (pH ≤ 7). Then, it is necessary to screen some peroxidase-mimetics substrates suitable for basic condition because that some peroxidase-mimetics leached ions in acidic solution. Read More

    Antibiotic-affinity strategy for bioluminescent detection of viable Gram-positive bacteria using daptomycin as recognition agent.
    Anal Chim Acta 2017 Sep 26;987:91-97. Epub 2017 Aug 26.
    Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China. Electronic address:
    A bioluminescent method was proposed for rapid detection of viable Gram-positive bacteria based on a novel antibiotic-affinity strategy on a magnetic beads (MBs) platform. Daptomycin, a highly efficient lipopeptide antibiotic for Gram-positive bacteria, was used as a recognition agent to functionalize MBs. The daptomycin-functionalized MBs showed high capture and concentration efficiency for Gram-positive bacteria due to the strong binding between daptomycin and bacterial cell membrane in the presence of Ca(2+) ion. Read More

    Nocturnal hypoglycemic alarm based on near-infrared spectroscopy: In vitro simulation studies.
    Anal Chim Acta 2017 Sep 28;987:81-90. Epub 2017 Aug 28.
    Department of Chemistry & Optical Science and Technology Center, University of Iowa, Iowa City, IA 52242, USA. Electronic address:
    An alarm algorithm for detecting episodes of nocturnal hypoglycemia is demonstrated in simulation studies that incorporate the use of a tissue phantom. Based on transmission spectra collected in the near-infrared combination region of 4000-5000 cm(-1), pattern recognition methods are used to classify spectra into alarm and non-alarm data classes on the basis of whether or not they signify a glucose excursion below a user-defined hypoglycemic alarm threshold. A reference spectrum and corresponding glucose concentration are acquired at the start of the monitoring period, and absorbance values of subsequent spectra are computed relative to this reference. Read More

    Urinary intermediates of tryptophan as indicators of the gut microbial metabolism.
    Anal Chim Acta 2017 Sep 26;987:72-80. Epub 2017 Aug 26.
    Research Centre for Toxic Compounds in the Environment (RECETOX), Brno, Czech Republic. Electronic address:
    While over 10% of the human metabolome is directly associated with the gut microbial metabolism, specific metabolites are largely uncharacterized. Therefore, methods for the identification and quantification of microbiota-associated metabolites in biological fluids such as urine or plasma are necessary in order to elucidate the molecular basis of host-microbiota interaction. In this study, we focused on the tryptophan metabolism, employing quantitative assays by ultra-high performance liquid chromatography (UHPLC) and tandem mass spectrometry, specifically selected reaction monitoring (SRM). Read More

    Polydopamine-functionalized poly(ether ether ketone) tube for capillary electrophoresis-mass spectrometry.
    Anal Chim Acta 2017 Sep 26;987:64-71. Epub 2017 Aug 26.
    Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing 10080, China. Electronic address:
    Capillary electrophoresis-mass spectrometry (CE-MS) is a hyphenated technique that combines the advantages like low sample consumption, high separation efficiency, short analytical time in CE and high sensitivity, powerful molecular structure elucidation in MS. Polyimide-coated fused silica capillary has become the most dominant capillary for CE, but it suffers from swelling and aminolysis of polyimide coating when treated with organic solvents and alkaline buffer in the CE-MS interface in which the polyimide coating at the end of the capillary is exposed to the solution, and this phenomenon can result in current instability, irregular electrospray and clogging at outlet after prolonged use. In this work, poly(ether ether ketone) (PEEK) capillary was explored as separation capillary for CE-MS. Read More

    Matrix-assisted laser desorption/ionization mass spectrometry for the analysis of polyamines in plant micro-tissues using cucurbituril as a host molecule.
    Anal Chim Acta 2017 Sep 26;987:56-63. Epub 2017 Aug 26.
    Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan 430072, China. Electronic address:
    In this study, a matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) strategy using cucurbit[n]uril (CB[n]) as a host molecule is proposed for the analysis of low molecular weight (LMW) compounds in complex samples. As a proof-of-concept, CB[6] was selected as the host molecule, and endogenous polyamines in plant tissue were chosen as the target analytes. Due to the molecular recognition and mass shifting properties of CB[6], the ionic signals associated with polyamines were moved to the higher mass region (>1000 Da) after specifically binding to CB[6], while signal interference derived from the conventional organic matrix and the complex sample matrix remained in the low mass region because of the incompatibility of their molecular size with CB[6] cavities. Read More

    Highly sensitive method for aldehydes detection: Application to furfurals analysis in raisin and bovine milk powder.
    Anal Chim Acta 2017 Sep 26;987:47-55. Epub 2017 Aug 26.
    Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, 430070 Wuhan, China. Electronic address:
    A pre-column fluorescent derivatization method based on nitrone formation has been applied to determine furfurals (e.g. furfural (F), 5-methyfurfural (5-MF) and 5-hydroxymethylfurfural (5-HMF)) in food samples for the first time. Read More

    A tri-metal centered metal-organic framework for solid-phase microextraction of environmental contaminants with enhanced extraction efficiency.
    Anal Chim Acta 2017 Sep 26;987:38-46. Epub 2017 Aug 26.
    MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, No.135, Xingang Xi Road, Guangzhou, Guangdong 510275, China. Electronic address:
    This study presents the preparation and the characterizations of six tri-metal centered metal-organic frameworks (tM-MOFs) as solid-phase microextraction (SPME) adsorbents. Possessing different proportions of Al, Ga and In atoms in their frameworks, the tM-MOF-based SPME coatings exhibited different extraction performance towards the organic pollutants. Extraction results showed that the M4 (Al0. Read More

    Electrochemical aptasensor for human osteopontin detection using a DNA aptamer selected by SELEX.
    Anal Chim Acta 2017 Sep 29;987:25-37. Epub 2017 Aug 29.
    CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
    A DNA aptamer with affinity and specificity for human osteopontin (OPN), a potential breast cancer biomarker, was selected using the SELEX process, considering its homology rate and the stability of its secondary structures. This aptamer exhibited a satisfactory affinity towards OPN, showing dissociation constants lower than 2.5 nM. Read More

    Determination of methotrexate in spiked human blood serum using multi-frequency electrochemical immittance spectroscopy and multivariate data analysis.
    Anal Chim Acta 2017 Sep 28;987:15-24. Epub 2017 Aug 28.
    Department of Chemistry, Umeå University, SE 90187 Umeå, Sweden. Electronic address:
    This article describes an attempt to develop a sensor based on multi-frequency immittance spectroscopy for the determination of methotrexate (MTX) in blood serum using gold electrodes modified with antibodies. The attachment of antibodies was monitored with electrochemical immittance spectroscopy (EIS) and X-ray photoelectron spectroscopy (XPS). The EIS measurements of MTX resulted in a data matrix of size 39 × 55. Read More

    Sensitive prostate specific antigen quantification using dihydrolipoic acid surface-functionalized phosphorescent quantum dots.
    Anal Chim Acta 2017 Sep 13;987:118-126. Epub 2017 Aug 13.
    Department of Physical and Analytical Chemistry, University of Oviedo, Avda. Julián Clavería 8, Oviedo 33006, Spain.
    Herein, high-quality Mn-doped ZnS quantum dots (QDs) have been synthesized using a facile approach directly in aqueous media. The surface of the obtained QDs was further modified by cap-exchange of the native cysteine shell with dihydrolipoic acid (DHLA) ligands resulting in nanocrystals with high water-stability having an intense phosphorescent signal. Covalent bioconjugation of the DHLA-coated nanoparticles with an anti-IgG antibody was then carried out. Read More

    Colorimetric biosensor based on a DNAzyme primer and its application in logic gate operations for DNA screening.
    Anal Chim Acta 2017 Sep 14;987:111-117. Epub 2017 Aug 14.
    Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100083, China; Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), Ministry of Agriculture, Beijing, 100083, China. Electronic address:
    A colorimetric biosensor for DNA screening was designed based on the conformational changes of the horseradish peroxidase (HRP)-mimicking DNAzyme. The scheme of DNA biosensing was designed based on the base pairing of DNAzyme sequence to inhibit the formation of HRP-mimicking hemin/G-quadruplex structures in the process of amplification. DNA could be amplified via the universal primer multiplex polymerase chain reaction (UP-M-PCR) and innovatively detected as color disappear in the reaction visible to the naked eye. Read More

    Ca(2+) detection utilising AlGaN/GaN transistors with ion-selective polymer membranes.
    Anal Chim Acta 2017 Sep 7;987:105-110. Epub 2017 Aug 7.
    School of Electrical, Electronic and Computer Engineering, The University of Western Australia, 35 Stirling Hwy., Perth, WA 6009, Australia. Electronic address:
    We demonstrate highly selective and sensitive potentiometric ion sensors for calcium ion detection, operated without the use of a reference electrode. The sensors consist of AlGaN/GaN heterostructure-based transistor devices with chemical functionalisation of the gate area using poly (vinylchloride)-based (PVC) membranes having high selectivity towards calcium ions, Ca(2+). The sensors exhibited stable and rapid responses when introduced to various concentrations of Ca(2+). Read More

    Polymer inclusion membranes (PIMs) in chemical analysis - A review.
    Anal Chim Acta 2017 Sep 15;987:1-14. Epub 2017 Jul 15.
    School of Chemistry, The University of Melbourne, Victoria 3010, Australia. Electronic address:
    This review highlights the increasing interest in polymer inclusion membranes (PIMs) in analytical chemistry as they are adapted to new and novel applications. PIMs are polymer-based liquid membranes and were first introduced 50 years ago as the sensing membranes in ion-selective electrodes and optodes. More recently however, PIMs have been used for other applications in analytical chemistry such as for sample separation, sample pre-concentration, electro-driven extraction, and passive sampling, and have also been incorporated into on-line and automated analysis systems. Read More

    Immunosensor array platforms based on self-assembled dithiols for the electrochemical detection of tetrodotoxins in puffer fish.
    Anal Chim Acta 2017 Oct 2;989:95-103. Epub 2017 Aug 2.
    IRTA, Ctra. Poble Nou, km 5.5, Sant Carles de la Ràpita, Spain. Electronic address:
    The recent detection of tetrodotoxins (TTXs) in European fish and shellfish has emphasized the urgent need to develop specific, selective, rapid and easy-to-use methods for their detection to assess the potential risk posed to human health. For this purpose, a dithiol self-assembled monolayer (SAM)-based immunoassay previously performed on maleimide plates (mELISA) has been adapted to gold electrode arrays for the development of an electrochemical immunosensor for TTX. The electrochemical SAM-based immunosensor designed herein, provided an oriented, stable and spaced sensing platform for the determination of TTX, attaining a limit of detection of 2. Read More

    A hydrogen peroxide sensor based on TNM functionalized reduced graphene oxide grafted with highly monodisperse Pd nanoparticles.
    Anal Chim Acta 2017 Oct 29;989:88-94. Epub 2017 Jul 29.
    Sen Research Group, Department of Biochemistry, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100 Kütahya, Turkey. Electronic address:
    Addressed herein, we report the synthesis and characterization of a tert-nonyl mercaptan (TNM) functionalized reduced graphene oxide (rGO) supported palladium (Pd) nanoparticles (NPs) (Pd/TNM@rGO) as electrochemical sensor. The highly monodisperse Pd/TNM@rGO nanocomposite was applied for electrochemical determination of hydrogen peroxide (H2O2) at a potential range of -0.6 to +0. Read More

    Potentiometric sensor for non invasive lactate determination in human sweat.
    Anal Chim Acta 2017 Oct 28;989:80-87. Epub 2017 Jul 28.
    National Research Council of Italy, C.N.R., Istituto di Chimica Dei Composti Organo Metallici-ICCOM- UOS Pisa, Area di Ricerca, Via G. Moruzzi 1, 56124, Pisa, Italy. Electronic address:
    The present work describes a non invasive lactate sensing in sweat during workout. The sensing system is based on a non-equilibrium potentiometric measure performed using disposable, chemically modified, screen printed carbon electrodes (SPCEs) that can be wetted with sweat during the exercise. The potentiometric signal, which is proportional to lactate concentration in sweat, is produced by a redox reaction activated by UV radiation, as opposed to the enzymatic reaction employed in traditional, blood-based measuring devices. Read More

    A novel substrate-inspired fluorescent probe to monitor native albumin in human plasma and living cells.
    Anal Chim Acta 2017 Oct 28;989:71-79. Epub 2017 Jul 28.
    Institute of Interdisciplinary Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address:
    Human albumin (HA) displays crucial roles in maintaining health and fighting diseases. Accurate determination of native HA in plasma or non-plasma samples are of immense significance in both basic research and clinical practice. Herein, a novel ratiometric two-photon fluorescent probe (N-butyl-4-(4-phenyl-benzoyloxy) 1,8-naphthalimide, BPBN) has been designed and developed for highly selective and sensitive sensing the enzymatic activities of HA, on the basis of its unique pseudo-esterase feature. Read More

    Derivatization enhanced separation and sensitivity of long chain-free fatty acids: Application to asthma using targeted and non-targeted liquid chromatography-mass spectrometry approach.
    Anal Chim Acta 2017 Oct 17;989:59-70. Epub 2017 Aug 17.
    State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macao. Electronic address:
    Long chain-free fatty acids (LCFFAs) play pivotal roles in various physiological functions, like inflammation, insulin resistance, hypertension, immune cell behavior and other biological activities. However, the detection is obstructed by the low contents, structural diversity, high structural similarity, and matrix interference. Herein, a fast cholamine-derivatization, within 1 min at room temperature, coupled with liquid chromatography-mass spectrometry (LC-MS) approach was developed to determine LCFFAs in complex samples. Read More

    Development of a validated LC- MS/MS method for the quantification of 19 endogenous asthma/COPD potential urinary biomarkers.
    Anal Chim Acta 2017 Oct 16;989:45-58. Epub 2017 Aug 16.
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada. Electronic address:
    Obstructive airways inflammatory diseases sometimes show overlapping symptoms that hinder their early and correct diagnosis. Current clinical tests are tedious and are of inadequate specificity in special population such as the elderly and children. Therefore, we are developing tandem mass spectrometric (MS/MS) methods for targeted analysis of urine biomarkers. Read More

    Paper spray and Kendrick mass defect analysis of block and random ethylene oxide/propylene oxide copolymers.
    Anal Chim Acta 2017 Oct 13;989:38-44. Epub 2017 Aug 13.
    Research Institute for Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
    Paper spray ionization coupled with a high-resolution time-of-flight mass spectrometer was applied to the analysis of 13 block and 2 random ethylene oxide/propylene oxide (EO/PO) copolymers as well as to standard samples of poly(ethylene oxide) and poly(propylene oxide) homopolymers. Paper spray mass spectra could be obtained rapidly and, unlike electrospray ionization, were not subject to contamination and sample carryover. For comparison, polyether samples were also measured on a MALDI/TOF system with ultrahigh mass resolving power. Read More

    Accurate and reliable quantification of the protein surface coverage on protein-functionalized nanoparticles.
    Anal Chim Acta 2017 Oct 13;989:29-37. Epub 2017 Aug 13.
    Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany. Electronic address:
    The ability to accurately quantify the protein coverage on nanoparticles is critical for assessing the quality of the surface chemistry and the success of the functionalization process of protein-nanoparticle conjugates. Surface coverage determination is therefore an integral part in the quality control of protein-modified nanoparticles in industrial nanotechnology. In this work, a novel and conventional method was established for direct quantification of the protein surface coverage on metallic nanoparticles. Read More

    Porous organic polymers with different pore structures for sensitive solid-phase microextraction of environmental organic pollutants.
    Anal Chim Acta 2017 Oct 14;989:21-28. Epub 2017 Aug 14.
    MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, No. 135, Xingang Xi Road, Guangzhou, Guangdong 510275, PR China. Electronic address:
    Adsorption capacity is the major sensitivity-limited factor in solid-phase microextraction. Due to its light-weight properties, large specific surface area and high porosity, especially tunable pore structures, the utilization of porous organic polymers as solid-phase microextraction adsorbents has attracting researchers' attentions. However, these works mostly concentrated on the utilization of specific porous organic polymers for preparing high-performance solid-phase microextraction coatings. Read More

    A magnetic field-directed self-assembly solid contact for construction of an all-solid-state polymeric membrane Ca(2+)-selective electrode.
    Anal Chim Acta 2017 Oct 25;989:15-20. Epub 2017 Aug 25.
    Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Provincial Key Laboratory of Coastal Environmental Processes, YICCAS, Yantai, Shandong 264003, PR China. Electronic address:
    A magnetic field-directed self-assembly solid contact has been proposed for developing an all-solid-state polymeric membrane Ca(2+)-selective electrode. The solid contact is prepared by physically adsorbing magnetic graphene powder on a magnetic gold electrode under the direction of the magnetic field. The proposed method for preparing solid contact avoids using the aqueous solutions and is simple, fast and general as compared to the multilayer drop-casting and electrodeposition methods. Read More

    Ultra-high performance supercritical fluid chromatography-mass spectrometry procedure for analysis of monosaccharides from plant gum binders.
    Anal Chim Acta 2017 Oct 21;989:112-120. Epub 2017 Jul 21.
    Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic. Electronic address:
    The ultra-high performance supercritical fluid chromatography-mass spectrometry (UHPSFC/MS) procedure for analysis of native monosaccharides was developed. Chromatographic conditions were investigated to separate a mixture of four hexoses, three pentoses, two deoxyhexoses and two uronic acids. Increasing water content in methanol modifier to 5% and formic acid to 4% improved peak shapes of neutral monosaccharides and allowed complete elution of highly polar uronic acids in a single run. Read More

    High sensitivity and selectivity in quantitative analysis of drugs in biological samples using 4-column multidimensional micro-UHPLC-MS enabling enhanced sample loading capacity.
    Anal Chim Acta 2017 Oct 4;989:104-111. Epub 2017 Aug 4.
    Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium.
    Sensitivity is often a critical parameter in quantitative bioanalyses in drug development. For liquid-chromatography-based methods, sensitivity can be improved by reducing the column diameter, but practical sensitivity gains are limited by the reduced sample loading capacity on small internal diameter (I.D. Read More

    Secondary ion mass spectrometry: The application in the analysis of atmospheric particulate matter.
    Anal Chim Acta 2017 Oct 24;989:1-14. Epub 2017 Jul 24.
    Key Laboratory for Advanced Materials and School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, PR China.
    Currently, considerable attention has been paid to atmospheric particulate matter (PM) investigation due to its importance in human health and global climate change. Surface characterization, single particle analysis and depth profiling of PM is important for a better understanding of its formation processes and predicting its impact on the environment and human being. Secondary ion mass spectrometry (SIMS) is a surface technique with high surface sensitivity, high spatial resolution chemical imaging and unique depth profiling capabilities. Read More

    Molecular absorption measurements with an optical fibre coupled array of ultra-violet light-emitting diodes.
    Anal Chim Acta 2017 Sep 12;986:95-100. Epub 2017 Jul 12.
    University of Basel, Department of Chemistry, Spitalstrasse 51, 4056 Basel, Switzerland. Electronic address:
    A photometric detector based on eight different light-emitting diodes covering the ultraviolet range from 255 nm to 350 nm is described. These are coupled with fused silica optical fibres to a conventional cuvette with 1 cm optical path length or to a low volume flow through cell for detection in high-performance liquid chromatography. Photodiodes are employed for the measurement of the transmitted intensity as well as of a reference signal and the photocurrents are processed with a log-ratio amplifier to obtain a voltage proportional to absorbance values. Read More

    Sphingolipids in marine microalgae: Development and application of a mass spectrometric method for global structural characterization of ceramides and glycosphingolipids in three major phyla.
    Anal Chim Acta 2017 Sep 21;986:82-94. Epub 2017 Jul 21.
    Lijing Chenhai Baoer Bio. Ltd., Lijiang, Yunnan 674100, China.
    Sphingolipid compositions are crucial for the structural and physiological properties of microalgae membranes. In the present study, we developed a quadrupole time-of-flight (Q-TOF) mass spectrometric method based on MS(E) data collection for the identification of sphingolipids with high efficiency, selectivity, sensitivity and mass accuracy and applied this method for precise structural identification and quantitative profiling of ceramides and glycosphingolipids in total lipid extracts from 17 strains of microalgae, including 11 strains of diatom, 3 strains of dinoflagellate and 3 strains of haptophyta. Using this method, four species of sphingolipids including 27 ceramides, 13 monosaccharide ceramides, 18 disaccharide ceramides and 18 trisaccharide ceramides were identified. Read More

    The 5-azoniaspiro[4.4]nonyl group for improved MS peptide analysis: A novel non-fragmenting ionization tag for mass spectrometric sensitive sequencing of peptides.
    Anal Chim Acta 2017 Sep 15;986:71-81. Epub 2017 Jul 15.
    Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland. Electronic address:
    A novel class of ionization tags, based on 5-azoniaspiro[4.4]nonyl (ASN(+)) scaffold were designed for improved analysis of peptides by electrospray tandem mass spectrometry (ESI-MS/MS). A new labeling agent, 1-{[3-oxo-3-(pentafluorophenoxy)propyl]carbamoyl}-5-azoniaspiro[4. Read More

    Molecularly imprinted polymers immobilized on 3D printed scaffolds as novel solid phase extraction sorbent for metergoline.
    Anal Chim Acta 2017 Sep 4;986:57-70. Epub 2017 Aug 4.
    Department of Bioanalysis, Laboratory of Food Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
    In the present work, a novel solid phase extraction (SPE) sorbent was developed based on molecularly imprinted polymers (MIPs) immobilized on 3D-printed scaffolds using polymer networks as MIP-immobilizing layer. MIPs were produced by precipitation polymerization in acetonitrile (ACN) using methacrylic acid (MAA) as functional monomer, trimethylolpropane trimethacrylate (TRIM) as crosslinker and metergoline as model template which allows final recognition of ergot alkaloid mycotoxins. Scanning electron microscopy (SEM) and dynamic light scattering (DLS) analyses showed an average MIP particle size of 457 ± 145 nm. Read More

    GC-MS based metabolomics of colon cancer cells using different extraction solvents.
    Anal Chim Acta 2017 Sep 14;986:48-56. Epub 2017 Jul 14.
    Laboratory of Foodomics, CIAL (CSIC), Nicolas Cabrera 9, 28049 Madrid, Spain. Electronic address:
    The increasing incidence of colorectal cancer enforces the development of novel methodologies and protocols to deepen in the molecular mechanisms that govern disease pathophysiological events. The aim of this work is to deepen in the optimum metabolite extraction protocol from adherent mammalian cells of colon cancer for high throughput metabolomics using gas chromatography coupled to mass spectrometry (GC-MS). GC-MS results showed that metabolic information obtained from colon cancer cells was highly dependent on metabolite extraction selection, which at the same time is extremely influenced by the analytical platform. Read More

    Photoelectrochemical detection of copper ions by modulating the growth of CdS quantum dots.
    Anal Chim Acta 2017 Sep 14;986:42-47. Epub 2017 Aug 14.
    CIC BiomaGUNE, Paseo de Miramón 182, 20014 Donostia-San Sebastián, Spain. Electronic address:
    We discovered that copper ions (Cu(2+)) catalyze the oxidation of cysteine (CSH) by oxygen (O2) to modulate the growth of CSH-capped cadmium sulfide (CdS) nanoparticles (NPs). This new chemical process was applied to sensitive fluorogenic and photoelectrochemical (PEC) detection of Cu(2+) ions in real samples of mineral and tap water using the photocatalytic activity of the resulting NPs. Disposable screen-printed electrodes (SPCEs) modified with electroactive polyvinylpyridine bearing osmium complex (Os-PVP) by cyclic voltammetry (CV) were employed for PEC analytical system. Read More

    Poly-l-cysteine/electrospun copper oxide nanofibers-zinc oxide nanoparticles nanocomposite as sensing element of an electrochemical sensor for simultaneous determination of adenine and guanine in biological samples and evaluation of damage to dsDNA and DNA purine bases by UV radiation.
    Anal Chim Acta 2017 Sep 29;986:25-41. Epub 2017 Jul 29.
    Electroanalytical Chemistry Laboratory, Faculty of Chemistry, University of Guilan, Namjoo Street, P.O. Box: 1914-41335, Rasht, Iran.
    A new nanocomposite film constructed of poly-l-cysteine/zinc oxide nanoparticles-electrospun copper oxide nanofibers (PLC/ZnO-NPs-CuO-NFs) was prepared on the surface of the graphite electrode (GE). The novel electrode was successfully applied for the simultaneous determination of guanine (G) and adenine (A), two of the most important components of DNA and RNA. The PLC/ZnO-NPs-CuO-NFs/GE enhanced the anodic peak currents of the purine bases conspicuously and could determine them sensitively and separately in 0. Read More

    Highly selective enrichment of phosphorylated proteins by using Spore@Fe(3+) microspheres.
    Anal Chim Acta 2017 Sep 14;986:161-170. Epub 2017 Jul 14.
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
    The advantages of spore-based microspheres include high monodispersity, presence of different functional groups (carboxylic, amino, and hydroxyl groups), facile industrial-scale preparation by using cell cultures via fermentation in a potentially cost effective and environment friendly manner, and high uniformity. We developed a novel spore@Fe(3+) microsphere for specific capture of phosphoproteins. Caseins (α-casein and β-casein) as phosphoproteins were used to evaluate binding capacity and enrichment factor. Read More

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