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    9086 results match your criteria Analytica Chimica Acta[Journal]

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    Readily prepared iminocoumarin for rapid, colorimetric and ratiometric fluorescent detection of phosgene.
    Anal Chim Acta 2018 Oct 21;1029:97-103. Epub 2018 Apr 21.
    Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, 430079, PR China. Electronic address:
    In this paper, a new colorimetric and ratiometric fluorescent probe for the rapid detection of phosgene is reported. This probe is based on a readily prepared and highly fluorescent iminocoumarin, which reacts rapidly with phosgene to form a cyclic carbamate product to produce, distinctive colorimetric and ratiometric fluorescent signal changes. The detection of phosgene with this probe is fast (complete within 2 min), highly selective and sensitive with a detection limit of 27 nM in solution. Read More

    Surface enhanced Raman spectroscopy based immunosensor for ultrasensitive and selective detection of wild type p53 and mutant p53.
    Anal Chim Acta 2018 Oct 21;1029:86-96. Epub 2018 Apr 21.
    Biophysics & Nanoscience Centre, DEB, Università della Tuscia, Viterbo, Italy.
    p53 is a powerful transcription factor playing a pivotal role in the prevention of cancer development and in maintaining genome integrity. This oncosuppressor is found to be functionally inactivated by mutations in many human tumors. Accordingly, wild type p53 and its oncogenic mutants represent valuable cancer biomarkers for diagnostic and prognostic purposes. Read More

    Interfacial potential barrier driven electrochemical detection of Cr.
    Anal Chim Acta 2018 Oct 16;1029:8-14. Epub 2018 May 16.
    College of Materials Science and Engineering, Ocean University of China, Qingdao 266071, China. Electronic address:
    3D NiO/polyaniline p-p junction foam was prepared and applied for electrochemical detection of Cr. The electrochemical detection using interfacial potential barrier was illustrated and a mature theoretical model was built to demonstrate the mechanism. Electrochemical sensing signals of targets can be revealed by changing the height of potential barrier after specific adsorption. Read More

    New colorimetric aptasensor for rapid on-site detection of Campylobacter jejuni and Campylobacter coli in chicken carcass samples.
    Anal Chim Acta 2018 Oct 26;1029:78-85. Epub 2018 Apr 26.
    Center for One Health, College of Veterinary Medicine, Konkuk University, Seoul, South Korea. Electronic address:
    Campylobacter is the most common cause of infectious intestinal disease, with nearly all cases caused by two species: C. jejuni and C. coli. Read More

    A homogeneous, Anti-dsDNA antibody-based assay for multicolor detection of cancer stem cell transcription factors.
    Anal Chim Acta 2018 Oct 26;1029:72-77. Epub 2018 Apr 26.
    Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China. Electronic address:
    Cancer stem cells (CSCs) are responsible for maintaining tumor growth, metastasis and recurrence. The high expression of cancer stem cell transcription factors (Oct4, Sox2 and Nanog) is a valuable prognostic factor, suggesting a higher risk of tumor recurrence and metastasis. So, the development of a convenient and cost-effective method for multiplex assay of these transcription factors (TFs) is highly required. Read More

    Nanobody-based dual epitopes protein identification (DepID) assay for measuring soluble CD38 in plasma of multiple myeloma patients.
    Anal Chim Acta 2018 Oct 26;1029:65-71. Epub 2018 Apr 26.
    Laboratory of Cytophysiology, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China. Electronic address:
    Background: CD38 is a surface membrane antigen highly expressed in malignant blood cells, such as multiple myeloma (MM). A soluble form of CD38 (sCD38) is also present in the plasma, deriving likely from the shedding from the cells. The plasma levels of sCD38 should thus correlate closely with the proliferation of the MM cells, allowing the development of a simple diagnostic blood test for monitoring the progress of the disease. Read More

    Bifunctional aptamer-mediated catalytic hairpin assembly for the sensitive and homogenous detection of rare cancer cells.
    Anal Chim Acta 2018 Oct 4;1029:58-64. Epub 2018 May 4.
    Department of Laboratory Medicine/Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, PR China. Electronic address:
    The presence of cancer cells in body fluids confirms the occurrence of metastasis and guides treatment. A simple, fast, and homogeneous fluorescent method was developed to detect cancer cells based on catalytic hairpin assembly (CHA) and bifunctional aptamers. The bifunctional aptamer had a recognition domain for binding to target cancer cells and an initiator domain for triggering the CHA reaction. Read More

    Comprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection.
    Anal Chim Acta 2018 Oct 4;1029:50-57. Epub 2018 May 4.
    iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. Electronic address:
    Data analysis represents a key challenge for untargeted metabolomics studies and it commonly requires extensive processing of more than thousands of metabolite peaks included in raw high-resolution MS data. Although a number of software packages have been developed to facilitate untargeted data processing, they have not been comprehensively scrutinized in the capability of feature detection, quantification and marker selection using a well-defined benchmark sample set. In this study, we acquired a benchmark dataset from standard mixtures consisting of 1100 compounds with specified concentration ratios including 130 compounds with significant variation of concentrations. Read More

    Normal-inverse bimodule operation Hadamard transform ion mobility spectrometry.
    Anal Chim Acta 2018 Oct 4;1029:44-49. Epub 2018 May 4.
    Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, China.
    In order to suppress or eliminate the spurious peaks and improve signal-to-noise ratio (SNR) of Hadamard transform ion mobility spectrometry (HT-IMS), a normal-inverse bimodule operation Hadamard transform - ion mobility spectrometry (NIBOHT-IMS) technique was developed. In this novel technique, a normal and inverse pseudo random binary sequence (PRBS) was produced in sequential order by an ion gate controller and utilized to control the ion gate of IMS, and then the normal HT-IMS mobility spectrum and the inverse HT-IMS mobility spectrum were obtained. A NIBOHT-IMS mobility spectrum was gained by subtracting the inverse HT-IMS mobility spectrum from normal HT-IMS mobility spectrum. Read More

    Colorimetric ionophore-based coextraction titrimetry of potassium ions.
    Anal Chim Acta 2018 Oct 7;1029:37-43. Epub 2018 May 7.
    Department of Inorganic and Analytical Chemistry, University of Geneva, Quai Ernest-Ansermet 30, CH-1211 Geneva, Switzerland. Electronic address:
    Potassium ion concentration can be successfully determined volumetrically by moving the titration from a homogeneous phase to a two phase solvent system. This is because potassium can be readily complexed in a selective and thermodynamically stable manner by ionophores such as valinomycin. Previous work demonstrated the successful titration of potassium by ion-exchange into an organic phase containing valinomycin, but the sample itself served as titrant, which is not sufficiently practical for routine applications. Read More

    Low-cost Scholl-coupling microporous polymer as an efficient solid-phase microextraction coating for the detection of light aromatic compounds.
    Anal Chim Acta 2018 Oct 11;1029:30-36. Epub 2018 May 11.
    MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, No. 135, Xingang Xi Road, Guangzhou, Guangdong, 510275, China. Electronic address:
    A cost-effective microporous polymer was synthesized using cheap monomer and catalyst via one-step Scholl-coupling reaction, and its chemical, morphological characteristics and pore structure were investigated. The as-synthesized polymer with large surface area and narrow pore distribution (centered in 1.2 nm) was prepared as a fiber coating for solid-phase microextraction (SPME). Read More

    A novel mode of DNA assembly at electrode and its application to protein quantification.
    Anal Chim Acta 2018 Oct 5;1029:24-29. Epub 2018 May 5.
    Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, People's Republic of China. Electronic address:
    Sensitive and specific detection of protein is of great significance for early diagnosis and prognosis of many diseases. However, great challenges remain unsolved including relative low sensitivity, high cost, long testing time, complicated instrument and laborious operation. To improve the performance of protein detection methods, development of fine reaction interface for recognition and signal amplification is of great importance. Read More

    Cost-effective synthesis of three-dimensional nitrogen-doped nanostructured carbons with hierarchical architectures from the biomass of sea-tangle for the amperometric determination of ascorbic acid.
    Anal Chim Acta 2018 Oct 16;1029:15-23. Epub 2018 May 16.
    Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Key Laboratory of Polyoxometalate Science of Ministry of Education, National & Local United Engineering Laboratory for Power Batteries, Department of Chemistry, Northeast Normal University, Changchun, 130024, PR China. Electronic address:
    In this work, the three-dimensional nitrogen-doped nanostructured carbons with hierarchical architectures (3D-NNCsHAs) with high density of defective sites, high surface area and pluralities of pore size distributions was prepared through the pyrolysis of sea-tangle (Laminaria japonica), an inexpensive, eco-friendly and abundant precursor. Benefitting from their structural uniqueness, a selective and sensitive ascorbic acid (AA) sensor based on 3D-NNCsHAs was developed. Compared to the glassy carbon electrode (GCE) and the carbon nanotubes modified GCE (CNTs/GCE), the 3D-NNCsHAs modified GCE (3D-NNCsHAs/GCE) presents higher performance towards the electrocatalysis and detection of AA, such as lower detection limit (1 μM), wider linear range (10-4410 μM) and lower electrooxidation peak potential (-0. Read More

    Centrifugal partition chromatography a first dimension for biomass fast pyrolysis oil analysis.
    Anal Chim Acta 2018 Oct 18;1029:116-124. Epub 2018 Apr 18.
    IFP Energies nouvelles, Rond-point de l'échangeur de Solaize BP 3, 69360, Solaize, France.
    Biomass fast pyrolysis oils contain molecules having a large variety of chemical functions and a wide range of molecular weights (from several tens to several thousand grams per mole). The good knowledge of their complex composition is essential for optimizing the conversion of bio-oils to biofuels, thereby requiring powerful separation techniques. In this work, we investigate the interest of centrifugal partition chromatography (CPC) as a first dimension for the analysis of a bio-oil. Read More

    Study of a complex secondary metabolites with potent anti-radical activity by two dimensional TLC/HPLC coupled to electrospray ionization time-of-flight mass spectrometry and bioautography.
    Anal Chim Acta 2018 Oct 18;1029:104-115. Epub 2018 Apr 18.
    Chair and Department of Pharmacognosy with Medicinal Plants Unit, Medical University, 1 Chodzki St., 20-093, Lublin, Poland. Electronic address:
    The high performance liquid chromatography (HPLC) coupled to electrospray ionization (ESI) octopole orthogonal acceleration time-of-flight (TOF) mass spectrometry (MS) was developed to separate secondary metabolites belonging to different groups of compounds with a wide range of polarity, i.e. phenolic acids, flavonoids, sesquiterpenes and others present in minute amounts, in a single run. Read More

    A lab-on-a-tip approach to make electroanalysis user-friendly and de-centralized: Detection of copper ions in river water.
    Anal Chim Acta 2018 Oct 4;1029:1-7. Epub 2018 May 4.
    Department of Chemical Science and Technologies, University of Rome "Tor Vergata", Via della Ricerca Scientifica 1, 00133, Rome, Italy.
    The development of portable and user-friendly sensing platforms is a hot topic in the field of analytical chemistry. Among others, electroanalytical approaches exhibit a high amenability for reaching this purpose, i.e. Read More

    Hydrophilic interaction chromatography coupled to tandem mass spectrometry as a method for simultaneous determination of guanidinoacetate and creatine.
    Anal Chim Acta 2018 Oct 29;1028:96-103. Epub 2018 Mar 29.
    Faculty of Sport and Physical Education, University of Novi Sad, Lovćenska 16, 21000, Novi Sad, Serbia; School of Medicine, University of Belgrade, Dr Subotića 8, 11000, Belgrade, Serbia.
    The biosynthesis of creatine (Cr) is closely related to the bioavailability of guanidinoacetate (GAA). The lack of one or the other may compromise their role in the energy transport and cell signaling. A reliable estimate of their levels in biological samples is imperative since they are important markers of many metabolic disorders. Read More

    High-frequency, dielectric spectroscopy for the detection of electrophysiological/biophysical differences in different bacteria types and concentrations.
    Anal Chim Acta 2018 Oct 23;1028:86-95. Epub 2018 Apr 23.
    Holistic Electronics Research Laboratory, Department of Electrical and Computer Engineering, University of Cyprus, Kallipoleos 75, 1678, Nicosia, Cyprus.
    This paper describes a novel technique to quantify and identify bacterial cultures of Bacillus Subtilis (2.10-1.30 × 10 CFU mL) and Escherichia Coli (1. Read More

    Novel epoxy-silica nanoparticles to develop non-enzymatic colorimetric probe for analytical immuno/bioassays.
    Anal Chim Acta 2018 Oct 24;1028:77-85. Epub 2018 Apr 24.
    Department of Chemistry, University of Connecticut, Storrs, CT, 06269-3060, USA; Institute of Materials Science, University of Connecticut, Storrs, CT, 06269-3136, USA; Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA; School of Chemistry, National University of Ireland at Galway, Galway, Ireland.
    We have developed a novel method to develop epoxy silica nanoparticles (EfSiNP) in a single pot. High surface coverage of epoxy functional groups between 150 and 57000 molecules per particles (∼10-10 molecules/mL of 200 nm EfSiNPs) was achieved for different preparation conditions. We then created a red colored probe by conjugating Fuchsin dye to the epoxy functionalities of EfSINPs. Read More

    The aptamer-thrombin-aptamer sandwich complex-bridged gold nanoparticle oligomers for high-precision profiling of thrombin by dark field microscopy.
    Anal Chim Acta 2018 Oct 21;1028:66-76. Epub 2018 Apr 21.
    Department of Chemistry, Capital Normal University, Beijing, 100048, China. Electronic address:
    We present a simple and efficient colorimetric assay strategy for ultrasensitive visual detection of human α-thrombin, which is essentially based on the formation of the DNA1-thrombin-DNA2 sandwich complex-bridged gold nanoparticle (Au NP) oligomers. Unlike the traditional colorimetric sensing strategies which induced the nanoparticle aggregates with uncontrolled aggregate size. In this work, the DNA1with rich G bases was firstly conjugated on the surfaces of Au NPs fixed on the hexadecyl trimethylammonium bromide (CTAB)-coated glass slide, and thrombin was captured by the DNA1. Read More

    Enzyme-linked immunosorbent assays for therapeutic drug monitoring coumarin oral anticoagulants in plasma.
    Anal Chim Acta 2018 Oct 21;1028:59-65. Epub 2018 Apr 21.
    Nanobiotechnology for Diagnostics (Nb4D), IQAC-CSIC, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Jordi Girona 18-26, 08034, Barcelona, Spain.
    The development of high-throughput immunochemical assays to assist on precision medicine for patients treated with coumarin oral anticoagulants (OA) is reported. The assays are able to quantitate Warfarin (W) and/or Acenocoumarol (ACL) directly in plasma samples without any previous sample pretreatment. The detectabilities (W, 3. Read More

    Use of MPA-capped CdS quantum dots for sensitive detection and quantification of Co ions in aqueous solution.
    Anal Chim Acta 2018 Oct 27;1028:50-58. Epub 2018 Apr 27.
    Laboratoire d'Optique et Biosciences, INSERM, CNRS UMR 7645, Ecole Polytechnique, 91128, Palaiseau, France. Electronic address:
    Water soluble CdS quantum dots (QDs) were synthesized by a simple aqueous chemical route using mercaptopropionic acid (MPA) as a stabilizer. These QDs had a fluorescence emission band maximum at 540 nm with a FWHM ∼130 nm and a quantum yield of ∼12%. Transmission electronic microscopy images were used to determine the QD diameter of 8. Read More

    A novel label-free fluorescent sensor for highly sensitive detection of bleomycin based on nitrogen-doped graphene quantum dots.
    Anal Chim Acta 2018 Oct 4;1028:45-49. Epub 2018 May 4.
    Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China. Electronic address:
    In this work, we presented a novel label-free biosensor for rapid detection of bleomycinsulphate (BLM). The biosensor was based on the fluorescent "turn off-on" of nitrogen-doped graphene quantum dots (N-GQDs), which was prepared in a green way from citric acid and ammonia. The richness of carboxyl groups on the N-GQDs enabled strong adsorption of ssDNA to the surface of N-GQDs through π-π stacking interactions, resulting in the effective fluorescence quenching of N-GQDs system. Read More

    Benzophenone used as the photochemical reagent for pinpointing C=C locations in unsaturated lipids through shotgun and liquid chromatography-mass spectrometry approaches.
    Anal Chim Acta 2018 Oct 21;1028:32-44. Epub 2018 Apr 21.
    State Key Laboratory of Electroanalytical Chemistry, National Center of Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. Electronic address:
    Unsaturated lipids exhibit different physiological significances due to the different locations of the carbon-carbon double bond (C=C). Identifying lipid isomers with mass-based methods remains challenging. Xia's group has been successfully employed Paternò-Büchi (PB) reaction, a photochemical reaction with UV irradiation, coupled with tandem mass spectrometry (MS/MS) to identify and quantify unsaturated lipids in complex mixtures. Read More

    Based on ZnSe quantum dots labeling and single particle mode ICP-MS coupled with sandwich magnetic immunoassay for the detection of carcinoembryonic antigen in human serum.
    Anal Chim Acta 2018 Oct 18;1028:22-31. Epub 2018 Apr 18.
    Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China. Electronic address:
    A highly sensitive sandwich-type magnetic immunoassay based on inductively coupled plasma mass spectrometry detection in single particle mode, with ZnSe Quantum dots (QDs) serving as model tags, was proposed. The transient signals induced by the flash of ions (Zn) in the plasma torch from the ionization of nanoparticles tagged on antibody were recorded in a single particle mode. The frequency of transient signals is directly related to the concentration of nanoparticle tags, and the concentration of nanoparticle tagged antibodies can be quantified by the frequency of transient signals. Read More

    Use of exogenous volatile organic compounds to detect Salmonella in milk.
    Anal Chim Acta 2018 Oct 18;1028:121-130. Epub 2018 Apr 18.
    Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. Electronic address:
    Rapid, sensitive, and selective detection and identification of pathogenic bacteria is required in terms of food security. In this study, exogenous VOCs liberated by Salmonella strains have been identified and quantified via head space-solid phase microextraction gas chromatography mass spectrometry (HS-SPME-GC-MS) in milk samples. The specific enzymes targeted for detection and/or differentiation of Salmonella were C8 esterase, α-galactosidase and pyrrolidonyl peptidase using the following enzyme substrates: 2-chlorophenyl octanoate, phenyl α-d-galactopyranoside and L-pyrrollidonyl fluoroanilide, respectively. Read More

    Covalent bonding of Schiff base network-1 as a stationary phase for capillary electrochromatography.
    Anal Chim Acta 2018 Oct 18;1028:113-120. Epub 2018 Apr 18.
    Department of Chemistry, Capital Normal University, Beijing, 100048, PR China.
    Covalent organic frameworks (COFs), featuring low densities, high surface areas, and good thermal and chemical stabilities, are gradually attracting interest in the field of analytical chemistry. A type of microporous polymer network material named Schiff base network-1 (SNW-1) was introduced into a capillary column through covalent bonding. The obtained SNW-1-coated capillary column was characterized by thermogravimetric analysis, scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. Read More

    Behavior of selenium hydride in heated quartz tube and dielectric barrier discharge atomizers.
    Anal Chim Acta 2018 Oct 21;1028:11-21. Epub 2018 May 21.
    Czech Academy of Sciences, Institute of Analytical Chemistry, Veveří 97, CZ-602 00, Brno, Czech Republic.
    Atomization of SeH in an externally heated multiple microflame quartz tube atomizer (MMQTA) as well as planar dielectric barrier discharge (DBD) atomizer was investigated using a variety of probes. Deposits of Se on inner surfaces of the atomizers were quantified and their distribution visualized by autoradiography with Se radiotracer. The gas phase fraction of Se transported beyond the confines of the atomizers was also determined. Read More

    Characterization of polymer-coated CdSe/ZnS quantum dots and investigation of their behaviour in soil solution at relevant concentration by asymmetric flow field-flow fractionation - multi angle light scattering - inductively coupled plasma - mass spectrometry.
    Anal Chim Acta 2018 Oct 29;1028:104-112. Epub 2018 Mar 29.
    Université de Pau et des Pays de l'Adour, CNRS, Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux (IPREM), UMR 5254, Helioparc, 2 Avenue Pierre Angot, 64053, PAU, France. Electronic address:
    A careful separation, identification and characterization of polymer-coated quantum dots (P-QDs) in complex media such as soil solution is the key point to understand their behaviour and to accurately predict their fate in the environment. In the present study, a synthesized CdSe/ZnS core/shell P-QDs suspension, proved to be stable for at least six months, was investigated with respect to P-QDs dimension, structure and elemental composition. Separation of P-QDs and size distribution determination were carried out by Asymmetric Flow Field-Flow Fractionation (AF4) - Multi Angle Light Scattering (MALS). Read More

    Modern data science for analytical chemical data - A comprehensive review.
    Anal Chim Acta 2018 Oct 15;1028:1-10. Epub 2018 May 15.
    FrieslandCampina, Amersfoort, The Netherlands. Electronic address:
    Efficient and reliable analysis of chemical analytical data is a great challenge due to the increase in data size, variety and velocity. New methodologies, approaches and methods are being proposed not only by chemometrics but also by other data scientific communities to extract relevant information from big datasets and provide their value to different applications. Besides common goal of big data analysis, different perspectives and terms on big data are being discussed in scientific literature and public media. Read More

    On-chip dual enzyme activity assay to investigate regulation of the transamidase and kinase activities of transglutaminase 2.
    Anal Chim Acta 2018 Oct 18;1027:92-100. Epub 2018 Apr 18.
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-Do, 200-701, South Korea. Electronic address:
    Transglutaminase 2 (TGase2), a multifunctional enzyme exhibiting both transamidase and kinase activity, is involved in a variety of cellular processes and diseases. However, details of the regulation of TGase2 have not been reported due to the lack of a suitable assay to examine both activities on the same platform under near-physiologic conditions. Thus, we developed an on-chip dual enzyme activity assay for TGase2 to simultaneously monitor the transamidase and kinase activities. Read More

    Metal-organic frameworks in proteomics/peptidomics-A review.
    Anal Chim Acta 2018 Oct 2;1027:9-21. Epub 2018 May 2.
    Laboratory of High-Resolution Mass Spectrometry Technologies, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian, 116023, China. Electronic address:
    Peptides exert essential role in physiological processes. It is yet a big challenge to finish the mapping of global peptides in complex biological systems due to the interference from the matrices. Recently, the metal-organic frameworks (MOFs) have been applied in proteomics/peptidomics since the unique pore structures and versatile surface properties of MOFs. Read More

    Accurate SERS detection of malachite green in aquatic products on basis of graphene wrapped flexible sensor.
    Anal Chim Acta 2018 Oct 26;1027:83-91. Epub 2018 Apr 26.
    School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China; Shenzhen Institute of Huazhong University of Science and Technology, 518000, Shenzhen, China. Electronic address:
    Malachite Green (MG) is a banned pesticide for aquaculture products. As a required inspection item, its fast and accurate determination before the products' accessing market is very important. Surface enhanced Raman scattering (SERS) is a promising tool for MG sensing, but it requires the overcoming of several problems such as fairly poor sensitivity and reproducibility, especially laser induced chemical conversion and photo-bleaching during SERS observation. Read More

    Multi-DNAzymes-functionalized gold nanoparticles for ultrasensitive chemiluminescence detection of thrombin on microchip.
    Anal Chim Acta 2018 Oct 18;1027:76-82. Epub 2018 Apr 18.
    Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China. Electronic address:
    Herein, a chemiluminescence assay with dual signal amplification has been developed based on multi-DNAzymes-functionalized gold nanoparticles (AuNPs) using in situ rolling circle amplification (RCA) for ultrasensitive detection of thrombin on microchip. In this assay, AuNPs was functionalized by aptamer and multi-RCA primer for amplification, and thrombin was sandwiched between the aptamer modified on the microchannel and the aptamer linked AuNP. The further amplification was realized by in situ RCA to expand specific oligonucleotides chains on the AuNPs and produce particular multi-DNAzymes. Read More

    Electrokinetic transport properties of deoxynucleotide monophosphates (dNMPs) through thermoplastic nanochannels.
    Anal Chim Acta 2018 Oct 21;1027:67-75. Epub 2018 Apr 21.
    Department of Chemistry, Department of Mechanical Engineering, The University of Kansas, USA; Department of Cancer Biology, Kansas University Medical Center, USA; NIH Biotechnology Resource Center of BioModular Multiscale Systems for Precision Medicine, USA; Ulsan National Institute of Science and Technology, Ulsan, South Korea. Electronic address:
    The electrokinetic behavior of molecules in nanochannels (<100 nm in length) have generated interest due to the unique transport properties observed that are not seen in microscale channels. These nanoscale dependent transport properties include transverse electromigration arising from partial electrical double layer overlap, enhanced solute/wall interactions due to the small channel diameter, and field-dependent intermittent motion produced by surface roughness. In this study, the electrokinetic transport properties of deoxynucleotide monophosphates (dNMPs) were investigated, including the effects of electric field strength, surface effects, and composition of the carrier electrolyte (ionic concentration and pH). Read More

    A film-based integrated chip for gene amplification and electrochemical detection of pathogens causing foodborne illnesses.
    Anal Chim Acta 2018 Oct 18;1027:57-66. Epub 2018 Apr 18.
    Nano-bio Application Team, National NanoFab Center (NNFC), 291 Deahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. Electronic address:
    Given the increased interest in public hygiene due to outbreaks of food poisoning, increased emphasis has been placed on developing novel monitoring systems for point-of-care testing (POCT) to evaluate pathogens causing foodborne illnesses. Here, we demonstrate a pathogen evaluation system utilizing simple film-based microfluidics, featuring simultaneous gene amplification, solution mixing, and electrochemical detection. To minimize and integrate the various functionalities into a single chip, patterned polyimide and polyester films were mainly used on a polycarbonate housing chip, allowing simple fabrication and alignment, in contrast to conventional polymerase chain reaction, which requires a complex biosensing system at a bench-top scale. Read More

    Speeding up the extraction of hexabromocyclododecane enantiomers in soils and sediments based on halogen bonding.
    Anal Chim Acta 2018 Oct 4;1027:47-56. Epub 2018 May 4.
    Departamento de Química Analítica, Instituto Universitario de Investigación en Química Fina y Nanoquímica IUIQFN, Facultad de Ciencias, Universidad de Córdoba, Campus de Rabanales, Edificio Marie Curie, Córdoba, E-14071, Argentina.
    Halogen bonding (XB), a highly energetic and directional interaction, is here proposed as a new mechanism to increase solute solubilisation in solvent extractions. The approach is illustrated by the extraction of hexabromocyclododecane (HBCD) enantiomers in soils and sediments using supramolecular solvents (SUPRAS) containing XB donors in their structure. SUPRAS consisting of inverted hexagonal aggregates of decanoic acid, synthesized by water-induced coacervation of the amphiphile in tetrahydrofuran (THF), were explored for this purpose. Read More

    Infrared laser ablation and capture of enzymes with conserved activity.
    Anal Chim Acta 2018 Oct 26;1027:41-46. Epub 2018 Apr 26.
    Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana, 70803, United States. Electronic address:
    Infrared (IR) laser ablation at 3 μm wavelength was used to extract enzymes from tissue and quantitatively determine their activity. Experiments were conducted with trypsin, which was ablated, captured and then used to digest bovine serum albumin (BSA). BSA digests were evaluated using matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) and sequence coverage of 59% was achieved. Read More

    Ultrasensitive cathode photoelectrochemical immunoassay based on TiO photoanode-enhanced 3D CuO nanowire array photocathode and signal amplification by biocatalytic precipitation.
    Anal Chim Acta 2018 Oct 4;1027:33-40. Epub 2018 May 4.
    State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, PR China.
    Cathode photoelectrochemical immunoassay usually shows better anti-interference capacity toward real samples than anode photoelectrochemical immunoassay. However, its poor photocurrent response has greatly restricted the detection sensitivity. Herein, a promising ultrasensitive cathode photoelectrochemical immunoassay was developed based on TiO photoanode-enhanced 3D CuO nanowire array (NWA) photocathode, and coupled with signal amplification by horseradish peroxidase (HRP)-induced biocatalytic precipitation (BCP). Read More

    Highly-stable Li ion-selective electrodes based on noble metal nanostructured layers as solid-contacts.
    Anal Chim Acta 2018 Oct 11;1027:22-32. Epub 2018 May 11.
    Laboratory of Integrated System, EPFL, CH-1015, Lausanne, Switzerland.
    Nowadays the development of stable and highly efficient Solid-Contact Ion-Selective Electrodes (SC-ISEs) attracts much attention in the research community because of the great expansion of portable analytical devices. In this work, we present highly stable Li all-solid-state ISEs exploiting noble metals nanostructures as ion-to-electron transducers. The detection of lithium is essential for therapeutic drug monitoring of bipolar patients. Read More

    SPME-GC×GC-TOF MS fingerprint of virally-infected cell culture: Sample preparation optimization and data processing evaluation.
    Anal Chim Acta 2018 Oct 30;1027:158-167. Epub 2018 Mar 30.
    Thayer School of Engineering, Dartmouth College, Hanover, NH, 03755, United States; Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, United States.
    Untargeted metabolomics study of volatile organic compounds produced by different cell cultures is a field that has gained increasing attention over the years. Solid-phase microextraction has been the sampling technique of choice for most of the applications mainly due to its simplicity to implement. However, a careful optimization of the analytical conditions is necessary to obtain the best performances, which are highly matrix-dependent. Read More

    Capillary electrophoresis analysis of affinity to assess carboxylation of multi-walled carbon nanotubes.
    Anal Chim Acta 2018 Oct 29;1027:149-157. Epub 2018 Mar 29.
    C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV 26506, USA. Electronic address:
    Surface oxidation improves the dispersion of carbon nanotubes in aqueous solutions and plays a key role in the development of biosensors, electrochemical detectors and polymer composites. Accurate characterization of the carbon nanotube surface is important because the development of these nano-based applications depends on the degree of functionalization, in particular the amount of carboxylation. Affinity capillary electrophoresis is used to characterize the oxidation of multi-walled carbon nanotubes. Read More

    A multidimensional fractionation protocol for the oligomer analysis of oxidized waxes.
    Anal Chim Acta 2018 Oct 19;1027:137-148. Epub 2018 Mar 19.
    Department of Chemistry and Polymer Science, University of Stellenbosch, 7602, Matieland, South Africa. Electronic address:
    Oxidized waxes possess far superior properties as compared to the alkanes they are derived from. The separation of alkane oligomers via gas chromatography (GC) becomes a challenge when polar oxygen-containing functional groups are introduced or when higher molar masses are targeted. In the present study, the separation and analysis of oligomers in oxidized and non-oxidized waxes using different liquid chromatographic techniques are investigated. Read More

    Highly sensitive visual detection of amantadine residues in poultry at the ppb level: A colorimetric immunoassay based on a Fenton reaction and gold nanoparticles aggregation.
    Anal Chim Acta 2018 Oct 18;1027:130-136. Epub 2018 Apr 18.
    Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, And Beijing Laboratory for Food Quality and Safety, Beijing, 100193, People's Republic of China. Electronic address:
    Colorimetric biosensors for the on-site visual detection of veterinary drug residues are required for food control in developing countries and other resource-constrained areas, where sophisticated instruments may not be available. In this study, we developed a highly sensitive immunoassay for amantadine residues in poultry. By introducing a novel signal generation strategy into an indirect competitive immunoassay, a highly sensitive assay for amantadine residues in chicken was achieved for naked eye readout at the part per billion (ppb) level. Read More

    Electrochemically prepared oxygen and sulfur co-doped graphitic carbon nitride quantum dots for fluorescence determination of copper and silver ions and biothiols.
    Anal Chim Acta 2018 Oct 18;1027:121-129. Epub 2018 Apr 18.
    Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, PR China.
    Although great advances have been achieved in synthesis of fluorescent graphitic carbon nitride quantum dots (g-CN-dots), it is still challenging to develop g-CN-dots with high fluorescence quantum yield (FLQY) and multiple sensing functionalities. Herein, the oxygen and sulfur co-doped graphitic carbon nitride quantum dots (OS-g-CN-dots) with high FLQY of 33.9% were firstly synthesized by a simple electrochemical "tailoring" process. Read More

    Multifunctional GQDs-Concanavalin A@FeO nanocomposites for cancer cells detection and targeted drug delivery.
    Anal Chim Acta 2018 Oct 18;1027:109-120. Epub 2018 Apr 18.
    Institute of Environmental Engineering, National Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan, ROC; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101 Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan, ROC. Electronic address:
    Multifunctional nanocomposites containing intrinsic property for serving as the sensing elements as well as targeted nanoconjugates are highly preferred in various therapeutic applications. In this work, nanocomposites of graphene quantum dots (GQDs) and FeO with conjugation of lectin protein, concanavalin A, to form GQD-ConA@FeO nanocomposites are developed for both detection of cancer cell and release of drugs to HeLa cells. The GQD-ConA@FeO nanocomposites deposited on Pt electrode can detect cancerous HeLa cells over normal endothelial cells with a dynamic linear range of 5 × 10 to 1 × 10 cells mL with a detection limit of 273 cell mL. Read More

    Fluorescence-based immunosensor using three-dimensional CNT network structure for sensitive and reproducible detection of oral squamous cell carcinoma biomarker.
    Anal Chim Acta 2018 Oct 18;1027:101-108. Epub 2018 Apr 18.
    Department of Chemistry, Hanyang University, Seoul, 04763, South Korea; Institute of Nano Science & Technology, Hanyang University, Seoul, 04763, South Korea. Electronic address:
    A hierarchical three-dimensional network of carbon nanotubes on Si pillar substrate (3DN-CNTs) was developed for the accurate detection of oral squamous cell carcinoma (OSCC) in clinical saliva samples. The 3DN-CNTs were uniformly coated with a layer of aluminum oxides to enhance structural stability during biomarker detection. Cytokeratin-19 antigen (Cyfra 21-1) was utilized as a model biomarker of OSCC for fluorescence-based immunosensor using 3DN-CNTs (3DN-CNTs sensor). Read More

    Sensor systems for bacterial reactors: A new flavin-phenol composite film for the in situ voltammetric measurement of pH.
    Anal Chim Acta 2018 Oct 23;1027:1-8. Epub 2018 Apr 23.
    School of Engineering, Ulster University, Jordanstown, Northern Ireland, BT37 0QB, UK. Electronic address:
    Monitoring pH within microbial reactors has become an important requirement across a host of applications ranging from the production of functional foods (probiotics) to biofuel cell systems. An inexpensive and scalable composite sensor capable of monitoring the pH within the demanding environments posed by microbial reactors has been developed. A custom designed flavin derivative bearing an electropolymerisable phenol monomer was used to create a redox film sensitive to pH but free from the interferences that can impede conventional pH systems. Read More

    A high-resolution HPLC-QqTOF platform using parallel reaction monitoring for in-depth lipid discovery and rapid profiling.
    Anal Chim Acta 2018 Oct 18;1026:87-100. Epub 2018 Apr 18.
    School of BioSciences, University of Melbourne, Parkville, VIC 3010, Australia; Metabolomics Australia, School of BioSciences, University of Melbourne, Parkville, VIC 3010, Australia.
    Here, we developed a robust lipidomics workflow merging both targeted and untargeted approaches on a single liquid chromatography coupled to quadrupole-time of flight (LC-QqTOF) mass spectrometry platform with parallel reaction monitoring (PRM). PRM assays integrate both untargeted profiling from MS1 scans and targeted profiling obtained from MS/MS data. This workflow enabled the discovery of more than 2300 unidentified features and identification of more than 600 lipid species from 23 lipid classes at the level of fatty acid/long chain base/sterol composition in a barley root extracts. Read More

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