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    8814 results match your criteria Analytica Chimica Acta[Journal]

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    Quantitative determination of non-lactose milk oligosaccharides.
    Anal Chim Acta 2018 Jun 30;1010:86-96. Epub 2017 Dec 30.
    Nestlé Research Centre, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland.
    A method for the determination of non-lactose oligosaccharides (NLO) in milk using liquid chromatography has been developed. Oligosaccharides were labelled with a fluorescent tag, 2-aminobenzamide (2AB), and were identified by comparison of their retention times to those of oligosaccharide standards, their mass (as measured by mass spectrometry) and their fragmentation patterns in the mass spectrometer. The concentrations of the NLO in milk have been determined using 2 different approaches: (1) by preparing a calibration curve using genuine standards of each oligosaccharide. Read More

    Green-modified micellar liquid chromatography for isocratic isolation of some cardiovascular drugs with different polarities through experimental design approach.
    Anal Chim Acta 2018 Jun 2;1010:76-85. Epub 2018 Jan 2.
    Professor Massoumi Laboratory, Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran.
    Bilayer pseudo-stationary phase micellar liquid chromatography (MLC) was developed for simultaneous isocratic isolation of hydrochlorothiazide, as a basic-polar (hydrophilic) cardiovascular drug, as well as triamterene and losartan potassium, as acidic-nonpolar (hydrophobic) cardiovascular drugs. Utilizing a deep eutectic solvent (DES), as a novel green mobile phase additive in combination with acetonitrile (ACN) and acetic acid (ACA), drastically improved the chromatographic behavior of the drugs. Concentration of sodium dodecyl sulphate (SDS), as well as volume percentages of ACN, DES, and ACA were optimized by using a central composite design. Read More

    A regenerated "turn on" fluorescent probe for sulfide detection in live cells and read samples based on dihydroxyhemicyanine-Cudye.
    Anal Chim Acta 2018 Jun;1010:69-75
    Department of Forensic Chemistry, Criminal Investigation Police University of China, Shenyang 110854, PR China. Electronic address:
    A novel "turn-on" fluorescence probe (HHC)-Cufor sulfide (S) was synthesized and characterized based on dihydroxyhemicyanine-Cucomplex. The probe displayed high sensitivity and selectivity for Sover other analytes, including biothiols, NaCN, reactive oxygen species (ROS) and reactive nitrogen species (RNS) in aqueous solution, which was attributed to the large association constant and the fast kinetics of precipitation of CuS. The probe (HHC)-Cucan be regenerated and reversibly detected with Swith a remarkable red-fluorescent change by alternating the addition of Sand Cu. Read More

    Formulation of DNA chimera templates: Effects on emission behavior of silver nanoclusters and sensing.
    Anal Chim Acta 2018 Jun 20;1010:62-68. Epub 2018 Jan 20.
    School of Pharmacy, Faculty of Science, University of Nottingham Malaysia Campus, Jalan Broga, 43500, Semenyih, Selangor, Malaysia. Electronic address:
    Single strand DNA (ssDNA) chimeras consisting of a silver nanoclusters-nucleating sequence (NC) and an aptamer are widely employed to synthesize functional silver nanoclusters (AgNCs) for sensing purpose. Despite its simplicity, this chimeric-templated AgNCs often leads to undesirable turn-off effect, which may suffer from false positive signals caused by interference. In our effort to elucidate how the relative position of NC and aptamer affects the fluorescence behavior and sensing performance, we systematically formulated these NC and aptamer regions at different position in a DNA chimera. Read More

    Label-free and sensitive microRNA detection based on a target recycling amplification-integrated superlong poly(thymine)-hosted copper nanoparticle strategy.
    Anal Chim Acta 2018 Jun 19;1010:54-61. Epub 2018 Jan 19.
    State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha 410082, China. Electronic address:
    Poly(thymine)-hosted copper nanoparticles (poly T-CuNPs) have emerged as a promising label-free fluorophore for bioanalysis, but its application in RNA-related studies is still rarely explored. Herein, by utilizing duplex-specific nuclease (DSN) as a convertor to integrate target recycling mechanism into terminal deoxynucleotidyl transferase (TdT)-mediated superlong poly T-CuNPs platform, a specific and sensitive method for microRNA detection has been developed. In this strategy, a 3'-phosphorylated DNA probe can hybridize with target RNA and then be cut by DSN to produce 3'-hydroxylated fragments, which can be further tailed by TdT with superlong poly T for fluorescent CuNPs synthesis. Read More

    Rapid screening of basic colorants in processed vegetables through mass spectrometry using an interchangeable thermal desorption electrospray ionization source.
    Anal Chim Acta 2018 Jun 19;1010:44-53. Epub 2018 Jan 19.
    Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Chemistry, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address:
    Thermal desorption electrospray ionization/mass spectrometry (TD-ESI-MS) employing a quickly interchangeable ionization source is a relatively new ambient ionization mass spectrometric technique that has had, to date, only a limited number of applications related to food safety control. With reallocation of resources, this direct-analysis technique has had wider use in food analysis when operated in dual-working mode (pretreatment-free qualitative screening and conventional quantitative confirmation) after switching to an ambient ionization source from a traditional atmospheric pressure ionization source. Herein, we describe the benefits and challenges associated with the use of a TD-ESI source to detect adulterants in processed vegetables (PVs), as a proof-of-concept for the detection of basic colorants. Read More

    Highly sensitive glucose sensor based on monodisperse palladium nickel/activated carbon nanocomposites.
    Anal Chim Acta 2018 Jun 31;1010:37-43. Epub 2018 Jan 31.
    Sen Research Group, Biochemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100, Kütahya, Turkey. Electronic address:
    Glucose enzyme biosensors have been used for a variety of applications such as medical diagnosis, bioprocess engineering, beverage industry and environmental scanning etc. and there is still a growing interest in glucose sensors. For this purpose, addressed herein, as a novel glucose sensor, highly sensitive activated carbon (AC) decorated monodisperse nickel and palladium alloy nanocomposites modified glassy carbon electrode (Ni-Pd@AC/GCE NCs) have been synthesized by in-situ reduction technique. Read More

    A simple and automated sample preparation system for subsequent halogens determination: Combustion followed by pyrohydrolysis.
    Anal Chim Acta 2018 Jun 6;1010:29-36. Epub 2018 Feb 6.
    Departamento de Química, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil. Electronic address:
    A simple and automated system based on combustion followed by a pyrohydrolysis reaction was proposed for further halogens determination. This system was applied for digestion of soils containing high (90%) and also low (10%) organic matter content for further halogens determination. The following parameters were evaluated: sample mass, use of microcrystalline cellulose and heating time. Read More

    Feature expansion by a continuous restricted Boltzmann machine for near-infrared spectrometric calibration.
    Anal Chim Acta 2018 Jun 31;1010:20-28. Epub 2018 Jan 31.
    Ohio University Center for Intelligent Chemical Instrumentation, Department of Chemistry & Biochemistry, Clippinger Laboratories, Athens, OH, 45701-2979, USA. Electronic address:
    A modified algorithm for training a restricted Boltzmann machine (RBM) has been devised and demonstrated for improving the results for partial least squares (PLS) calibration of wheat and meat by near-infrared (NIR) spectroscopy. In all cases, the PLS calibrations improved by using the abstract features generated from the RBM so long as the nonlinear mapping increased the dimensionality. The evaluations were validated using bootstrapped Latin partitions (BLPs) with 5 bootstraps and 3-Latin partitions which proved useful because of the statistical learning and random initial conditions of the RBM networks. Read More

    Trace determination of antimony by hydride generation atomic absorption spectrometry with analyte preconcentration/atomization in a dielectric barrier discharge atomizer.
    Anal Chim Acta 2018 Jun 31;1010:11-19. Epub 2018 Jan 31.
    The Czech Academy of Sciences, Institute of Analytical Chemistry, Veveří 97, CZ-602 00, Brno, Czech Republic. Electronic address:
    Atomization conditions for antimony hydride in the plasma atomizer based on a dielectric barrier discharge (DBD) with atomic absorption spectrometric detection were optimized. Argon was found as the best discharge gas under a flow rate of 50 mL minwhile the DBD power was optimum at 30 W. Analytical figures of merit including interference study of As, Se and Bi have been subsequently investigated and the results compared to those found in an externally heated quartz tube atomizer (QTA). Read More

    Preparation of molecularly imprinted polymer nanobeads for selective sensing of carboxylic acid vapors.
    Anal Chim Acta 2018 Jun 30;1010:1-10. Epub 2018 Jan 30.
    Graduate School of Information Science and Electrical Engineering, Kyushu University, 744, Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
    The detection and discrimination of volatile carboxylic acid components, which are the main contributors to human body odor, have a wide range of potential applications. Here, a quartz crystal microbalance (QCM) sensor array based on molecularly imprinted polymer (MIP) nanobeads is developed for highly sensitive and selective sensing of typical carboxylic acid vapors, namely: propionic acid (PA), hexanoic acid (HA) and octanoic acid (OA). The MIP nanobeads were prepared by precipitation polymerization with methacrylic acid (MAA) as a functional monomer, trimethylolproane trimethacrylate (TRIM) as a crosslinker, and carboxylic acids (PA, HA and OA) as the template molecules. Read More

    Detection of urinary spermine by using silver-gold/silver chloride nanozymes.
    Anal Chim Acta 2018 Jun 20;1009:89-97. Epub 2018 Jan 20.
    Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan; Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung, 20224, Taiwan; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. Electronic address:
    In this paper, we report a simple one-step synthesis method for silver-gold bimetallic nanoparticles deposition on silver chloride nanosheets to form Ag-Au/AgCl nanohybrid with oxidase-like and peroxidase-like catalytic activity. We used these nanohybrid in the detection of spermine. First, 13 nm-sized Au NPs were synthesized by citrate reduction of HAuClsolution, and then, Agions were added to the solution without any purification. Read More

    Electrospin-coating of nitrocellulose membrane enhances sensitivity in nucleic acid-based lateral flow assay.
    Anal Chim Acta 2018 Jun 24;1009:81-88. Epub 2018 Jan 24.
    Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; Centre for the Initiation of Talent and Industrial Training (CITra), University of Malaya 50603 Kuala Lumpur, Malaysia. Electronic address:
    Point-of-care biosensors are important tools developed to aid medical diagnosis and testing, food safety and environmental monitoring. Paper-based biosensors, especially nucleic acid-based lateral flow assays (LFA), are affordable, simple to produce and easy to use in remote settings. However, the sensitivity of such assays to infectious diseases has always been a restrictive challenge. Read More

    Ultrasensitive detection of EGFR gene based on surface plasmon resonance enhanced electrochemiluminescence of CuZnInS quantum dots.
    Anal Chim Acta 2018 Jun 19;1009:73-80. Epub 2018 Jan 19.
    Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China. Electronic address:
    In our work, a novel DNA electrochemiluminescence (ECL) sensor based on CuZnInS quantum dots (QDs) and gold-nanoparticles (Au NPs) is developed for highly sensitive detection of epidermal growth factor receptor (EGFR) Gene, which has a close relation with the lung cancer. The CuZnInS QDs work as a novel kind of ECL luminophore, whose defect state emission is suitable for ECL sensing. To enhance the sensitivity of the sensing system, Au NPs are utilized creatively to strengthen the ECL intensity of CuZnInS QDaccording to the surface plasmon resonance (SPR) effect. Read More

    Detection of catechol using an electrochemical biosensor based on engineered Escherichia coli cells that surface-display laccase.
    Anal Chim Acta 2018 Jun;1009:65-72
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
    In this study, we report an electrochemical microbial biosensor that was made by immobilizing a bacterial laccase on the surface of Escherichia coli cells followed by adsorption of modified live cells onto a glassy-carbon electrode. Expression and surface localization of laccase on target cells were confirmed by Western blotting, flow cytometry assays and immunofluorescence microscopy observation. Increased tandem-aligned anchors with three repeats of the N-terminal domain of an ice nucleation protein were used to construct a highly active E. Read More

    Dried blood spots and parallel artificial liquid membrane extraction-A simple combination of microsampling and microextraction.
    Anal Chim Acta 2018 Jun 20;1009:56-64. Epub 2018 Jan 20.
    School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway. Electronic address:
    In this paper, parallel artificial liquid membrane extraction (PALME) was used for the first time to clean-up dried blood spots (DBS) prior to ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Fundamental studies exploring amongst others desorption from the DBS in alkaline or acidic aqueous conditions, total extraction time and absolute recoveries were executed. Desorption and PALME were performed using a set of two 96-well plates, one of them housing the sample and the other comprising the supported liquid membrane (SLM) and the acceptor solution. Read More

    In-syringe solid-phase extraction for on-site sampling of pyrethroids in environmental water samples.
    Anal Chim Acta 2018 Jun 19;1009:48-55. Epub 2018 Jan 19.
    Ministry of Education, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China. Electronic address:
    On-site sampling is an analytical approach that can ensure the accuracy of monitoring data and enhance the effectiveness of environmental protection measures. In the present work, an in-syringe solid-phase extraction (SPE) device was designed for on-site sampling of trace contaminants in environmental water samples followed by gas chromatography-mass spectrometry (GC-MS) analysis. Template assisted freeze casting followed by hydrazine vapor reduction approach was used to synthesize a hierarchical porous graphene aerogel (HPGA), which was used as the sorbent in the in-syringe SPE device. Read More

    A novel DNA sensor based on CNPs-PAMAM-PtPNPs to detect VKORC1 gene for guiding rational clinical therapy with warfarin.
    Anal Chim Acta 2018 Jun 31;1009:39-47. Epub 2018 Jan 31.
    Department of Orthopedics, Affiliated Hospital of Southwest Medical University, Luzhou, China. Electronic address:
    Reports have indicated that warfarin is the most widely prescribed anticoagulant. However, traditionally prescribed doses for each patient may be too low or too high. The therapeutic effect is often hindered by a lack of evidence-based medical information. Read More

    Nearest clusters based partial least squares discriminant analysis for the classification of spectral data.
    Anal Chim Acta 2018 Jun;1009:27-38
    School of Computing and Mathematics, Ulster University, BT37 0QB, Newtownabbey, Co. Antrim, UK.
    Partial Least Squares Discriminant Analysis (PLS-DA) is one of the most effective multivariate analysis methods for spectral data analysis, which extracts latent variables and uses them to predict responses. In particular, it is an effective method for handling high-dimensional and collinear spectral data. However, PLS-DA does not explicitly address data multimodality, i. Read More

    Robust boosting neural networks with random weights for multivariate calibration of complex samples.
    Anal Chim Acta 2018 Jun 3;1009:20-26. Epub 2018 Feb 3.
    State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Polytechnic University, Tianjin, 300387, PR China.
    Neural networks with random weights (NNRW) has been used for regression due to its excellent performance. However, NNRW is sensitive to outliers and unstable to some extent in dealing with the real-world complex samples. To overcome these drawbacks, a new method called robust boosting NNRW (RBNNRW) is proposed by integrating a robust version of boosting with NNRW. Read More

    Direct analysis of aluminum alloys by CSigma laser-induced breakdown spectroscopy.
    Anal Chim Acta 2018 Jun 20;1009:12-19. Epub 2018 Jan 20.
    Departamento de Física, Universidad Pública de Navarra, Campus de Arrosadía, E-31006 Pamplona, Spain; Institute for Advanced Materials (INAMAT), Public University of Navarre, Campus de Arrosadía, E-31006 Pamplona, Spain. Electronic address:
    We report the application of CSigma laser-induced breakdown spectroscopy (Cσ-LIBS) to quantitative analysis of aluminum alloys without sample preparation. Cσ-LIBS simplifies strongly the conventional calibration procedure of LIBS, replacing it with a characterization stage performed from the spectrum of a single standard sample. The aim of this work has been to provide a complete evaluation of the use of Cσ-LIBS for direct analysis by obtaining its figures of merit, including precision and limits of detection. Read More

    Highly selective and sensitive fluorescence sensing of nanomolar Znions in aqueous medium using Calix[4]arene passivated Carbon Quantum Dots based on fluorescence enhancement: Real-time monitoring and intracellular investigation.
    Anal Chim Acta 2018 Jun 6;1009:1-11. Epub 2018 Jan 6.
    Department of Chemistry, Panjab University, Chandigarh, 160014, India. Electronic address:
    Carbon Quantum Dots (CDs) owing to its unique photophysical properties have attracted immense consideration of the researchers in last decade to explore its applications in the fields of bio-imaging and sensing. In the present work, we have developed a novel CDs functionalized with Calix[4]arene derivative by hydrothermal route to detect biologically pertinent Znions. Surface modification of CDs enhances fluorescence efficiency apart from introducing active surface sites broadening its sensor capabilities. Read More

    Amplified fluorescence detection of serum prostate specific antigen based on metal-dependent DNAzyme assistant nanomachine.
    Anal Chim Acta 2018 May 10;1008:96-102. Epub 2018 Jan 10.
    Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, PR China. Electronic address:
    An amplified fluorescence biosensing strategy for serum prostate specific antigen (PSA) was developed on the basis of DNAzyme. In presence of cofactor Zn, Zn-dependent DNAzyme could cleave the hairpin substrate probes which were dispersed in solution and generate remarkable fluorescent signal. Taking advantage of the magnetic beads as a carrier, one target protein could bring plentiful hairpin substrate probes on to the electrode through a sandwich structure (Ab/PSA/biotin-Ab). Read More

    Nickel-mediated allosteric manipulation of G-quadruplex DNAzyme for highly selective detection of histidine.
    Anal Chim Acta 2018 May 3;1008:90-95. Epub 2018 Jan 3.
    Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, PR China; Nanjing Normal University Center for Analysis and Testing, Nanjing, 210023, PR China. Electronic address:
    Since abnormal metabolism of histidine (His) is defined as an indicator of several diseases, detection of His in biological fluids becomes increasingly urgent to us. However, due to similar structures and properties of different amino acids, selective quantification of His is difficulty, and typically needs the participation of special reagents. In this work, we report for the first time that nickel ions (Ni) can induce the allostery of G-quadruplex, and is thus able to manipulate the activity of G-quadruplex DNAzyme. Read More

    Double labelling of intracellular mitochondria and nucleolus using thiophene pyridium salt with high quantum yield as biosensor and its application in stimulated emission depletion nanoscopy.
    Anal Chim Acta 2018 May 2;1008:82-89. Epub 2018 Jan 2.
    Department of Chemistry, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei 230601, PR China; State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, PR China. Electronic address:
    Probe for dual-site target distinct subcellular compartments from cytosol and nucleus is an attractive approach, however, which was scarcely reported. Herein, a series of small-molecular thiophene pyridium salt derivatives (MitoNuc1-4) possessing water-soluble, high quantum yield and two-photon activity were rationally designed, and their structures were crystallographic confirmed. Systematic photophysical and biological imaging property investigations were carried out for them. Read More

    Investigation of hydride generation from arsenosugars - Is it feasible for speciation analysis?
    Anal Chim Acta 2018 May 19;1008:8-17. Epub 2018 Jan 19.
    Institute of Analytical Chemistry of the Czech Academy of Sciences, Veveří 97, 602 00 Brno, Czech Republic.
    Hydride generation (HG) from arsenosugars (dimethylarsinoylribosides) in batch and flow injection modes was studied. Its efficiency was found higher in HSOmedium than in HCl and higher in the batch mode than in the flow injection mode. To increase the efficiency in the flow injection mode a new generator with two inlets of NaBHsolution was designed. Read More

    High-pressure photon ionization time-of-flight mass spectrometry combined with dynamic purge-injection for rapid analysis of volatile metabolites in urine.
    Anal Chim Acta 2018 May;1008:74-81
    Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, People's Republic of China. Electronic address:
    Small molecule metabolites are widely used as biomarkers in the research field of metabolomics for disease diagnosis and exposure assessment. As a readily available biofluid containing plenty of volatile organic metabolites (VOMs), urine is ideal for non-invasive metabolomic analysis; however, there is still lack of rapid analysis method for VOMs in urine. Here we report a kind of rapid method for urine analysis by employing high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS) combined with dynamic purge-injection. Read More

    Improved approach for routine monitoring ofI activity andI/I atom ratio in environmental samples using TMAH extraction and ICP-MS/MS.
    Anal Chim Acta 2018 May 6;1008:66-73. Epub 2018 Jan 6.
    Department of Radiation Chemistry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan. Electronic address:
    To reconstructI deposition and identify the source of radioiodine due to the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident,I activity andI/I atom ratio should be obtained by preparing and analyzing large numbers of samples economically. In this study, great efforts were made to realize mild TMAH (tetramethyl ammonium hydroxide) extraction of environmental samples at 90 °C to obtain solutions suitable for the following triple-quadrupole inductively coupled plasma-mass spectrometry (ICP-QQQ) MS/MS mode analysis. After releasing iodine from organic matter in the TMAH extraction solution via KSOoxidation, organic matter was removed effectively by solvent extraction and back-extraction to avoid a serious matrix effect during ICP-QQQ analysis. Read More

    Highly selective determination of ultratrace inorganic arsenic species using novel functionalized miniaturized membranes.
    Anal Chim Acta 2018 May 29;1008:57-65. Epub 2017 Dec 29.
    University of Silesia, Institute of Chemistry, ul. Szkolna 9, 40-006 Katowice, Poland. Electronic address:
    A simple method for highly selective determination of trace and ultratrace arsenic ions, i.e. arsenite and arsenate, was developed. Read More

    A novel aptamer-based online magnetic solid phase extraction method for the selective determination of 8-hydroxy-2'-deoxyguanosine in human urine.
    Anal Chim Acta 2018 May 8;1008:48-56. Epub 2018 Jan 8.
    Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China. Electronic address:
    In this work, an innovative magnetic aptamer adsorbent (FeO-aptamer MNPs) was synthesized for the selective extraction of 8-hydroxy-2'-deoxyguanosine (8-OHdG). Amino-functionalized-FeOwas crosslinked with 8-OHdG aptamer by glutaraldehyde and fixed into a steel stainless tube as the sorbent of magnetic solid phase extraction (MSPE). After selective extraction by the aptamer adsorbent, the adsorbed 8-OHdG was desorbed dynamically and online analyzed by high performance liquid chromatography-mass spectrometry (HPLC-MS). Read More

    Synthesis of gold-palladium nanowaxberries/dodecylamine-functionalized graphene quantum dots-graphene micro-aerogel for voltammetric determination of peanut allergen Ara h 1.
    Anal Chim Acta 2018 May 30;1008:38-47. Epub 2018 Jan 30.
    School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, China; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Wuxi, 214122, China. Electronic address:
    The paper reports synthesis of gold-palladium nanowaxberries(AuPd NWs)/dodecylamine-functionalized graphene quantum dots(D-GQDs)-graphene micro-aerogel(GMA). D-GQDs was used as a solid particle surfactant for stabilizing Pickering emulsion of toluene-in-graphene oxide aqueous dispersion. Graphene oxide sheets in the aqueous phase are reduced by hydrazine hydrate, diffused into the toluene droplet and self-assembled into graphene oxide micro-gels. Read More

    Voltammetric determination of tartaric acid in wines by electrocatalytic oxidation on a cobalt(II)-phthalocyanine-modified electrode associated with multiway calibration.
    Anal Chim Acta 2018 May 20;1008:29-37. Epub 2018 Jan 20.
    Universidade Federal Rural de Pernambuco, Departamento de Química, 52171-900 Recife, Pernambuco, Brazil. Electronic address:
    The electrocatalytic oxidation of tartaric acid on a carbon paste electrode modified with cobalt (II)-phthalocyanine was demonstrated and applied to the development of a highly sensitive, simple, fast and inexpensive voltammetric sensor to determine tartaric acid. The electrochemical behavior of the modified electrode was investigated by cyclic and square wave voltammetry, and the effect of experimental variables, such as dispersion and loading of cobalt (II)-phthalocyanine, together with optimum conditions for sensing the analyte by square wave voltammetry were assessed. In addition, the absence of a significant memory effect combined with the ease of electrode preparation led to the development of a sensitive and direct method to determine tartaric acid in wines. Read More

    Triethylamine-assisted Mg(OH)coprecipitation/preconcentration for determination of trace metals and rare earth elements in seawater by inductively coupled plasma mass spectrometry (ICP-MS).
    Anal Chim Acta 2018 May 20;1008:18-28. Epub 2018 Jan 20.
    Department of Chemistry, Physics and Atmospheric Sciences, Jackson State University, Jackson, MS 39217, USA.
    In this paper, we report an improved magnesium hydroxide, Mg(OH), coprecipitation method for the determination of 16 trace elements (Al, V, Cr, Mn, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Se, Sb, Sn and Pb) and 18 rare earth elements (REEs), including Sc, Y, U and Th in seawater and estuarine water samples. The procedure involves coprecipitation of the trace elements and REEs on Mg(OH)upon addition of a small volume of triethylamine (TEA) followed by analysis of the dissolved pellet solutions by inductively coupled plasma mass spectrometry (ICP-MS). Three-step sequential coprecipitation was carried out on 10 mL aliquots of seawater to eliminate the matrix ions and to preconcentrate the analytes of interest into a 1 mL final volume. Read More

    "Turn-off" fluorescent sensor based on double quantum dots coupled with chemometrics for highly sensitive and specific recognition of 53 famous green teas.
    Anal Chim Acta 2018 May 6;1008:103-110. Epub 2018 Jan 6.
    State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:
    Fluorescent "turn-off" sensors based on double quantum dots (QDs) has attracted increasing attention in the detection of many materials due to their properties such as more useful information, higher fluorescence efficiency and stability compared with the fluorescent "turn-off" sensors based on single QDs. In this work, highly sensitive and specific method for recognition of 53 different famous green teas was developed based on the fluorescent "turn-off" model with water-soluble ZnCdSe-CdTe double QDs. The fluorescence of the two QDs can be quenched by different teas with varying degrees, which results in the differences in positions and intensities of two peaks. Read More

    Quantitative and rapid detection of C-reactive protein using quantum dot-based lateral flow test strip.
    Anal Chim Acta 2018 May 8;1008:1-7. Epub 2018 Jan 8.
    Key Laboratory for Special Functional Materials of Ministry of Education, Henan University, Henan, 475004, China. Electronic address:
    A novel QD-based immunoassay on a paper-based lateral flow system has been developed to quantitatively detect C-reactive protein (CRP). Different standard CRP antigens from 1 to 200 μg mLwere diluted 200-fold and only 60 μL diluted sample were needed to load onto the sample pad. The QD fluorescence signals on the test line and the control line were able to be observed within 3 min after the initiation of assay, and the limit of detection was as sensitive as 0. Read More

    Simultaneous determination of 11 phthalate esters in bottled beverages by graphene oxide coated hollow fiber membrane extraction coupled with supercritical fluid chromatography.
    Anal Chim Acta 2018 May 28;1007:71-79. Epub 2017 Dec 28.
    Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, 310028, China. Electronic address:
    Phthalate esters (PAEs) are a group of serious environmental pollutants, which lead to carcinogenicity or tumorigenicity in human body. In this study, a rapid, sensitive and green method by graphene oxide coated hollow fiber membrane extraction (GO-HFME) coupled with supercritical fluid chromatography (SFC) was proposed for the determination of 11 phthalate esters in bottled beverages. Graphene oxide (GO) was prepared and coated onto a porous hollow fiber membrane (HFM) to reinforce the efficiency of membrane extraction. Read More

    The label-free immunosensor based on rhodium@palladium nanodendrites/sulfo group functionalized multi-walled carbon nanotubes for the sensitive analysis of carcino embryonic antigen.
    Anal Chim Acta 2018 May 30;1007:61-70. Epub 2017 Dec 30.
    School of Chemical Engineering, Shandong University of Technology, Zibo, 255049, PR China.
    In this work, bimetallic core-shell rhodium@palladium nanodendrites (Rh@Pd NDs) loaded on sulfo group functionalized multi-walled carbon nanotubes (MWCNTs-SOH) were combined to form Rh@Pd NDs/MWCNTs-SOH nanocomposites. And the composites were used to construct a simple and label-free electrochemical immunosensor for carcino embryonic antigen (CEA) detection using differential pulse voltammetry (DPV). Rh@Pd NDs with dendritic nanostructure not only provide abundant catalytically active sites, but also increase the loading of antibody, which could improve the analytical performance and result in high sensitivity. Read More

    Double-enhanced lateral flow immunoassay for potato virus X based on a combination of magnetic and gold nanoparticles.
    Anal Chim Acta 2018 May 2;1007:50-60. Epub 2018 Jan 2.
    A.N. Bach Institute of Biochemistry, Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospect 33, 119071 Moscow, Russia. Electronic address:
    This study presents the joint use of magnetic nanoparticles (MNPs) and gold nanoparticles (GNPs) for double enhancement in a lateral flow immunoassay (LFIA). The study realizes two types of enhancement: (1) increasing the concentration of analytes in the samples using conjugates of MNPs with specific antibodies and (2) increasing the visibility of the label through MNP aggregation caused by GNPs. The proposed strategy was implemented using a LFIA for potato virus X (PVX), a significant potato pathogen. Read More

    Citrate-capped silver nanoparticles as a probe for sensitive and selective colorimetric and spectrophotometric sensing of creatinine in human urine.
    Anal Chim Acta 2018 May 28;1007:40-49. Epub 2017 Dec 28.
    Institute of Infectious Disease and Molecular Medicine, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town 7925, South Africa. Electronic address:
    Urinary creatinine concentration is a critical physiological parameter that enables reliable assessment of patient renal function and diagnosis of a broad spectrum of diseases. In this study, a simple and inexpensive sensor comprising monodisperse, citrate-capped silver nanoparticles (cc-AgNPs) was developed, which enabled rapid, sensitive and selective quantitation of creatinine directly in unprocessed urine. The mechanism of this sensor entails the creatinine-mediated aggregation of the cc-AgNPs (within 1 min) under alkaline conditions (pH 12). Read More

    Rotational paper-based electrochemiluminescence immunodevices for sensitive and multiplexed detection of cancer biomarkers.
    Anal Chim Acta 2018 May 27;1007:33-39. Epub 2017 Dec 27.
    Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. Electronic address:
    This paper describes a novel rotational paper-based analytical device (RPAD) to implement multi-step electrochemiluminescence (ECL) immunoassays. The integrated paper-based rotational valves can be easily controlled by rotating paper discs manually and this advantage makes it user-friendly to untrained users to carry out the multi-step assays. In addition, the rotational valves are reusable and the response time can be shortened to several seconds, which promotes the rotational paper-based device to have great advantages in multi-step operations. Read More

    Single cell patterning for high throughput sub-cellular toxicity assay.
    Anal Chim Acta 2018 May 23;1007:26-32. Epub 2017 Nov 23.
    Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA. Electronic address:
    Cell population based toxicity assays cannot distinguish responses of single cells and sub-cellular organelles; while single cell assays are limited by low statistical power due to small number of cells examined. This article reports a new single cell array based toxicity assay, in which cell responses at population level, single cell level and sub-cellular level can be obtained simultaneously at high throughput. The single cell array was produced by microcontact printing and selected area cell attachment, and exposed to damaging X-ray radiation, which was followed by fluorescence imaging after staining. Read More

    A high resolution atmospheric pressure matrix-assisted laser desorption/ionization-quadrupole-orbitrap MS platform enables in situ analysis of biomolecules by multi-mode ionization and acquisition.
    Anal Chim Acta 2018 May 6;1007:16-25. Epub 2018 Jan 6.
    School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, United States; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, 53705, United States. Electronic address:
    Introduced in 2000, atmospheric pressure (AP)/matrix-assisted laser desorption/ionization (MALDI) has attracted substantial attention in the mass spectrometry community due to its ease of sample introduction and handling, interchangeability with ESI source and capability of analyzing volatile species. In this study, an AP/MALDI source with ultra-high spatial resolution was coupled to a Q Exactive HF orbitrap mass spectrometer for high resolution in situ analysis by MALDI, laserspray ionization (LSI) and matrix assisted ionization (MAI) without instrument modification. LSI and MAI generated multiply charged ions, which expanded the mass detection range and improved fragmentation efficiency. Read More

    Additive Partial Least Squares for efficient modelling of independent variance sources demonstrated on practical case studies.
    Anal Chim Acta 2018 May 2;1007:10-15. Epub 2018 Jan 2.
    RECENDT - Research Center for Non-Destructive Testing, Altenbergerstrasse 69, Linz, Austria. Electronic address:
    A model recalibration method based on additive Partial Least Squares (PLS) regression is generalized for multi-adjustment scenarios of independent variance sources (referred to as additive PLS - aPLS). aPLS allows for effortless model readjustment under changing measurement conditions and the combination of independent variance sources with the initial model by means of additive modelling. We demonstrate these distinguishing features on two NIR spectroscopic case-studies. Read More

    Simultaneous detections of genetic fragment and single nucleotide mutation with a three-tiered output for tuberculosis diagnosis.
    Anal Chim Acta 2018 May 30;1007:1-9. Epub 2017 Dec 30.
    Department of Chemistry, Tunghai University, Taichung, 40704, Taiwan. Electronic address:
    Tuberculosis (TB) remains one of the major infectious diseases worldwide. The pathogenic bacterium, Mycobacterium tuberculosis (M.tb), continuously evolves strains carrying drug-resistance genes, thus posing a growing challenge to TB prevention and treatment. Read More

    SERS of cells: What can we learn from cell lysates?
    Anal Chim Acta 2018 Apr 15;1005:93-100. Epub 2017 Dec 15.
    Dept. of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy. Electronic address:
    Surface-enhanced Raman spectroscopy (SERS) is a promising and emerging technique to analyze the cellular environment. We developed an alternative, rapid and label-free SERS-based method to get information about the cellular environment by analyzing cells lysates, thus avoiding the need to incorporate nanoparticles into cells. Upon sonicating and filtrating cells, we obtained lysates which, mixed with Au or Ag nanoparticles, yield stable and repeatable SERS spectra, whose overall profile depends on the metal used as substrate, but not on the buffer used for the lysis process. Read More

    A new 3D printed radial flow-cell for chemiluminescence detection: Application in ion chromatographic determination of hydrogen peroxide in urine and coffee extracts.
    Anal Chim Acta 2018 Apr 2;1005:81-92. Epub 2018 Jan 2.
    Australian Centre for Research on Separation Science (ACROSS), School of Physical Sciences, University of Tasmania, Sandy Bay, Hobart 7001, Tasmania, Australia; ARC Centre of Excellence for Electromaterials Science, School of Physical Sciences, University of Tasmania, Sandy Bay, Hobart 7001, Tasmania, Australia. Electronic address:
    A new polymer flow-cell for chemiluminescence detection (CLD) has been designed and developed by diverging multiple linear channels from a common centre port in a radial arrangement. The fabrication of radial flow-cell by 3D PolyJet printing and fused deposition modeling (FDM) has been evaluated, and compared with a similarly prepared spiral flow-cell design commonly used in chemiluminescence detectors. The radial flow-cell required only 10 h of post-PolyJet print processing time as compared to ca. Read More

    Attenuated Total Reflectance Fourier Transformation Infrared spectroscopy fingerprinted online monitoring of the kinetics of circulating Butyrylcholinesterase enzyme during metabolism of bambuterol.
    Anal Chim Acta 2018 Apr 28;1005:70-80. Epub 2017 Dec 28.
    Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, El-Kasr El-Aini Street, ET-11562 Cairo, Egypt.
    We have described a continuous flow ATR-FTIR method for measuring some of the Butyrylcholinesterase enzyme kinetics (Kand V). This is done by developing a circulating system to be close as much as possible to the human circulation using human serum as a source of the enzyme with adjusted pH, isotonicity and temperature to give the maximum affinity of the enzyme towards its substrate (bambuterol). The experiment was running continuously for 90 min to monitor the production of terbutaline from the zero time of its appearance with a measured spectrum in each minute using ZnSe prism. Read More

    Integration of paper-based microarray and time-of-flight secondary ion mass spectrometry (ToF-SIMS) for parallel detection and quantification of molecules in multiple samples automatically.
    Anal Chim Acta 2018 Apr 28;1005:61-69. Epub 2017 Dec 28.
    Department of Materials Science and Engineering, National Taiwan University, Taipei, Taiwan; Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan. Electronic address:
    With its low-cost fabrication and ease of modification, paper-based analytical devices have developed rapidly in recent years. Microarrays allow automatic analysis of multiple samples or multiple reactions with minimal sample consumption. While cellulose paper is generally used, its high backgrounds in spectrometry outside of the visible range has limited its application to be mostly colorimetric analysis. Read More

    Sodium dodecyl sulfate removal during electrospray ionization using cyclodextrins as simple sample solution additive for improved mass spectrometric detection of peptides.
    Anal Chim Acta 2018 Apr 28;1005:54-60. Epub 2017 Dec 28.
    Australian Centre for Research on Separation Science, School of Physical Sciences-Chemistry, University of Tasmania, Hobart, TAS, 7001, Australia. Electronic address:
    Sodium dodecyl sulfate (SDS) removal is a vital procedure in SDS-assisted bottom-up proteomics because SDS affects the quality of the data in electrospray ionization mass spectrometry (ESI-MS). SDS removal methods provide efficient removal of SDS and improved peptide analysis, but would usually require time, specialised devices, and experienced analysts. Here, by simple addition of γ-cyclodextrin (γ-CD) to the solution at concentrations 1 to 2x the SDS in the sample, the SDS related signals in positive ionization ESI-MS can be significantly removed (70-99% reduction), without an additional sample manipulation step of extraction or purification. Read More

    Ionic liquid based ultrasound assisted dispersive liquid-liquid micro-extraction for simultaneous determination of 15 neurotransmitters in rat brain, plasma and cell samples.
    Anal Chim Acta 2018 Apr 28;1005:43-53. Epub 2017 Dec 28.
    Analytical Chemistry Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; System Toxicology Group, Health Risk Assessment, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India. Electronic address:
    Neurotransmitters are signaling molecules which play a key role in the central nervous system allowing signal transmission in the neuronal synapses. The role of these compounds is very crucial in the biological systems. A rapid, sensitive, economical and derivatisation free method has been developed for the analysis of 15 neurotransmitters in a single run on liquid chromatography tandem mass spectrometry. Read More

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