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Pneumologie 2021 Jun 11;75(6):439-446. Epub 2021 Jun 11.

Klinik für Thoraxchirurgie, Regiomed Kliniken GmbH, Sonneberg/Coburg.

Background:  Chylothorax is a multifactorial complication, usually caused by surgery or traumatic injury, and more rarely by malignant disease. Because of the lack of prospective, randomised trials, the evidence-based treatment rests upon personal experience, but ideally taking into account retrospective analysis.

Material And Methods:  The aim of this review is to provide a comprehensive overview of the currently available modern treatment options. Read More

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

Laboratory of Neuro-organic Chemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.

Alzheimer's disease is a growing general health concern with huge implications for individuals and society. Beta boswellic acid, a major compound of the plant, has long been used for the treatment of various inflammatory diseases. The exact mechanism of beta boswellic acid action in Alzheimer's disease pathogenesis remains unclear. Read More

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Herbacetin is a bioactive flavanol compound that has various pharmacological effects. However, the pharmacokinetic characteristics have not been thoroughly investigated. Previously, we screened a natural compound library and identified herbacetin as a potent CYP blocker. Read More

Analyst 2021 Jun 12. Epub 2021 Jun 12.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 210023, Nanjing, China.

Nanopore electrochemistry, as one of the promising tools for single molecule sensing, has proved its capability in DNA sequencing and protein analysis. To achieve a high resolution for obtaining molecular information, the nanopore electrochemical technique not only urgently requires an appropriate nanopore sensing interface with atomic resolution but also requires advanced instrumentation and its related data processing methods. In order to reveal the fundamental biological process and process the point-of-care diagnosis, it is necessary to use a nanopore sensing instrument with a high amperometric and temporal resolution as well as high throughput. Read More

PLoS One 2021 11;16(6):e0252647. Epub 2021 Jun 11.

Department of Marine Biology and Ecology, Rosenstiel School of Marine and Atmospheric Science, University of Miami, Miami, FL, United States of America.

Aging of the nervous system is typified by depressed metabolism, compromised proteostasis, and increased inflammation that results in cognitive impairment. Differential expression analysis is a popular technique for exploring the molecular underpinnings of neural aging, but technical drawbacks of the methodology often obscure larger expression patterns. Co-expression analysis offers a robust alternative that allows for identification of networks of genes and their putative central regulators. Read More

J Neurosci Nurs 2021 Jun 10. Epub 2021 Jun 10.

Questions or comments about this article may be directed to Mo-Kyung Sin, PhD RN, at M.-K.S. is an Associate Professor, Seattle University College of Nursing, Seattle, WA. Haily Ho, BSN RN, Providence Regional Medical Center, Everett, WA. Isabel Jose, is BSN Student, Seattle University College of Nursing, Seattle, WA. Molly Cheesman, is BSN Student, Seattle University College of Nursing, Seattle, WA. Christina Garrison, is BSN Student, Seattle University, Seattle, WA. Krista Bishop, BSN RN, Providence Regional Medical Center, Everett, WA. Samantha Taber, is BSN Student, Seattle University, Seattle, WA. Jennifer Witt, MD, is Neurologist, Movement Disorders, Swedish Neuroscience Institute, Seattle, WA.

Abstract: BACKGROUND: Depression and anxiety are common but underrecognized and undertreated nonmotor symptoms of Parkinson disease (PD) due to their diagnostic criteria overlapping with other PD symptoms, limited randomized controlled studies in this specific population, and the need for multidisciplinary expertise. The purpose of this article is to offer evidence-based solutions for managing comorbid depression and anxiety in patients with PD through a case study analysis. CASE STUDY: A case study is used to illustrate the somatic manifestations of anxiety in PD that leads to diagnostic challenge and multidisciplinary management. Read More

J Neurosci Nurs 2021 Jun 10. Epub 2021 Jun 10.

Questions or comments about this article may be directed to Gulsah Kose, Lecturer, PhD RN, at G.K. is Assistant Professor, Health Science Faculty, Department of Nursing, Mugla Sitki Kocman University, Muğla, Turkey. Keziban Şirin, RN, is Chief Nurse, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Turkey. Mehtap Balin Inel, is NSICU Nurse and Neurosurgical Nurse, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Turkey. Sevcan Mertoglu, is NSICU Nurse and Neurosurgical Nurse, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Turkey. Raziye Aksakal, is NSICU Nurse and Neurosurgical Nurse, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Turkey. Şule Kurucu, is NSICU Nurse and Neurosurgical Nurse, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Abstract: PURPOSE: The aim of this study was to identify the prevalence of, and factors affecting, postoperative delirium (POD) in patients in the neurosurgical intensive care unit. METHODS: A cross-sectional study of 127 Turkish neurosurgical intensive care unit patients admitted between May 2018 and May 2019 was conducted. Patients were assessed for the development of POD using the Intensive Care Delirium Screening Checklist. Read More

J Neurosci Nurs 2021 Jun 10. Epub 2021 Jun 10.

Questions or comments about this article may be directed to Nneka L. Ifejika, MD MPH, at N.L.I. is Section Chief of Stroke Rehabilitation, Departments of Physical Medicine and Rehabilitation, Neurology, and Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX. Yahaddy Riley, BSN RN CRRN, is RN II, Zale Lipshy University Hospital, University of Texas Southwestern Medical Center. Jacqueline Stitt, MSN RN CRRN, is RN II, Zale Lipshy University Hospital, University of Texas Southwestern Medical Center. Cynthia M. Hill, BRN, RN, is Nurse Manager, Zale Lipshy University Hospital, University of Texas Southwestern Medical Center. Sonja E. Stutzman, PhD, is Manager of Clinical Research, Neuroscience Nursing Research Center, O'Donnell Brain Institute, University of Texas Southwestern Medical Center. Aardhra M. Venkatachalam, MPH, is Clinical Data Specialist, Neuroscience Nursing Research Center, O'Donnell Brain Institute, University of Texas Southwestern Medical Center. Veronica Aguilera, is Nursing Student, Texas Woman's University; Interviewer, Neuroscience Nursing Research Center, O'Donnell Brain Institute, University of Texas Southwestern Medical Center.

Abstract: BACKGROUND: Information on nurse satisfaction and unit acuity is scarce in the literature. The purpose of this study is to evaluate the effect of the MATRIX Staffing Grid (MSG) on nurse assignment satisfaction in a 20-bed inpatient rehabilitation facility. METHODS: Prospective systematic implementation study of the MSG occurred in 5 phases: development, baseline, run-in, implementation, and sustainability. Read More

J Neurosci Nurs 2021 Jun 10. Epub 2021 Jun 10.

Questions or comments about this article may be directed to Li-Hong Wan, PhD RN, L.H.W. is a Professor, School of Nursing, Sun Yat-sen University, Guangzhou, China. Zhuo-Ran Li, BSc, is Master Student, School of Nursing, Sun Yat-sen University, Guangzhou, China. Heng-Fang Ruan, MSc RN, is Head Nurse, Department of Neurology and Stroke Center, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Li-Ping Shen, BSc RN, is Head Nurse, Department of Neurology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Xiao-Pei Zhang, MSc RN, is Head Nurse, Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.

Abstract: BACKGROUND: Previous research has shown that men and women have different levels of stroke knowledge and differing health behaviors, which are important factors affecting blood pressure, as hypertension is a key risk factor for stroke occurrence. There has been little research on the effects of sex on the association between these 2 variables before the onset of stroke among Chinese hypertensive patients. METHODS: A cross-sectional study and a convenience sampling method were used. Read More

Pediatr Emerg Care 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Emergency Medicine, Children's National Hospital, Washington, DC.

Objectives: The aims of this study were to assess whether bullying experience among youths is associated with firearm access and to evaluate assault perpetration risk factors between bullied and nonbullied adolescents.

Methods: This was a secondary analysis of a cross-sectional survey designed to measure self-reported social determinants of health and behavioral health risks among adolescents (13-21 years) in a pediatric emergency department between July 2017 and August 2019. Participants were included in this subanalysis if they responded to a survey item that assessed bullying. Read More

Nurs Res 2021 Jun 11. Epub 2021 Jun 11.

Marquette University College of Nursing, Milwaukee, WI University of Wisconsin-Madison Research Design and Statistics Unit, Madison, WI.

Background: Global health care initiatives emphasize the importance of engaging patients in their health care to improve the patient's experience and outcomes. Assessing patient preferences for engagement is critical, as there are many ways patients can engage in their care and preferences vary across individuals.

Objective: The primary purpose of this study was to evaluate the effect of implementation of the Patient Preferences for Engagement Tool 13-Item Short Form (PPET13) during hospitalization on patient and nurse experience of engagement. Read More

J Neurosurg Anesthesiol 2021 Jun 10. Epub 2021 Jun 10.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA Department of Anesthesiology, MMIMSR, MM (DU), Mullana, Haryana, India Bernard Becker Medical Library Department of Anesthesiology, Perioperative and Pain Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO.

One of the main concerns of intraoperative hypotension is adequacy of cerebral perfusion, as cerebral blood flow decreases passively when mean arterial pressure falls below the lower limit of cerebral autoregulation. Treatment of intraoperative hypotension includes administration of drugs, such as inotropes and vasopressors, which have different pharmacological effects on cerebral hemodynamics; there is no consensus on the preferred drug to use. We performed a network meta-analysis (NMA) to pool and analyze data comparing the effect on cerebral oxygen saturation (ScO2) measured by cerebral oximetry of various inotropes/vasopressors used to treat intraoperative hypotension. Read More

Clin J Pain 2021 Jun 11. Epub 2021 Jun 11.

Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Health Outcomes & Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA Institute for Pharmaceutical Outcomes & Policy, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA Division of Pharmaceutical Outcomes and Policy, University of North Carolina School of Pharmacy, Chapel Hill, North Carolina, USA Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA UNC Hospitals Pain Management Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Anesthesiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Objective: Morphine-standardized doses are used in clinical practice and research to account for molecular potency. 90 milligrams of morphine equivalents (MME) per day are considered a "high dose" risk threshold in guidelines, laws, and by payers. Although ubiquitously cited, the "CDC definition" of daily MME lacks a clearly defined denominator. Read More

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: To report a 10-year follow-up case of the first lamellar keratoplasty treatment with acellular porcine corneal stroma (APCS).

Methods: A 62-year-old woman was diagnosed with a fungal corneal ulcer and received lamellar keratoplasty treatment with APCS in 2010. The 10-year follow-up results were evaluated by slit lamp biomicroscopy, anterior segment optical coherence tomography, in vivo confocal microscopy, and corneal biomechanics analysis. Read More

J Pediatr Orthop 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopaedic Surgery, Brown University/Warren Alpert School of Medicine Warren Alpert School of Medicine at Brown University Brown University, Providence, RI Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA.

Background: Pediatric and adolescent forearm fractures are among the most common injuries treated by orthopaedic surgeons. Recent literature shows that there has been an increased interest in operative management for these injuries. The purpose of the current study was to examine the trends in case volume, patient age, surgeon fellowship training, and postoperative complications of surgically treated pediatric forearm fractures over >15-year period of American Board of Orthopaedic Surgery (ABOS) Part II Oral Examination candidates. Read More

Med Care 2021 Jun 11. Epub 2021 Jun 11.

Center for Healthcare Organization and Implementation Research, VA Bedford Healthcare System, Bedford Department of Population and Quantitative Health Sciences, Division of Health Informatics and Implementation Science, University of Massachusetts Medical School, Worcester Section of Endocrinology, Diabetes, and Metabolism, Boston University School of Medicine Medical Service, VA Boston Healthcare System Evans Department of Medicine, Boston University School of Medicine Medical Service and Section of Infectious Diseases, VA Boston Healthcare System, Boston Harvard Medical School, Cambridge Department of Population and Quantitative Health Sciences, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester Section of Pulmonary, Allergy, Sleep, and Critical Care Medicine, Boston University School of Medicine, Boston, MA.

Background: Strong relationships and effective communication between clinicians support care coordination and contribute to care quality. As a new mechanism of clinician communication, electronic consultations (e-consults) may have downstream effects on care provision and coordination.

Objective: The objective of this study was to understand primary care providers' and specialists' perspectives on how e-consults affect communication and relationships between clinicians. Read More

Nanotechnology 2021 Jun 11. Epub 2021 Jun 11.

Ioffe Institute, Polytekhnicheskaya st., 26, Sankt-Peterburg, Sankt-Peterburg, 194021, RUSSIAN FEDERATION.

Young's modulus of tapered mixed composition (zinc-blende with a high density of twins and wurtzite with a high density of stacking faults) Gallium Phosphide (GaP) nanowires (NWs) was investigated by atomic force microscopy (AFM). Experimental measurements were performed by obtaining bending profiles of as-grown inclined GaP NWs deformed by applying a constant force to a series of NW surface locations at various distances from the NW/substrate interface. Numerical modeling of the experimental data on bending profiles was done by applying the Euler-Bernoulli beam theory. Read More

J Phys Condens Matter 2021 Jun 11. Epub 2021 Jun 11.

Department of Physics, Tezpur University (Central University), Napaam, Tezpur 784028, Tezpur, INDIA.

Weak-coupling phenomena of the two-dimensional Hubbard model is gaining momentum as a new interesting research field due to its extraordinarily rich behavior as a function of the carrier density and model parameters. Salmhofer [Commun. Math. Read More

Physiol Meas 2021 Jun 11. Epub 2021 Jun 11.

Biomedical Engineering, TOBB Ekonomi ve Teknoloji Universitesi, Sogutozu Cad. No:43, Cankaya, 06560, TURKEY.

Objective: In this study, we conducted a comparative analysis of deep convolutional neural network (CNN) models in predicting Obstructive Sleep Apnea (OSA) using electrocardiograms. Unlike other studies in the literature, this study automatically extracts time-frequency features by using CNNs instead of manual feature extraction from ECG recordings.

Approach: The proposed model generates scalogram and spectrogram representations by transforming preprocessed 30-sec ECG segments from time domain to the frequency domain using Continuous Wavelet Transform (CWT) and Short Time Fourier transform (STFT), respectively. Read More

Nanotechnology 2021 Jun 11. Epub 2021 Jun 11.

Xi'an University of Posts and Telecommunications, Xi'an University of Posts and Telecommunications, No. 618, West Chang'an Avenue, Xi'an, Shaanxi, 710121, CHINA.

Chiral plasmonic nanostructures have become a promising platform for polarization converters and molecular analysis. However, the circular dichroism (CD) of planar chiral plasmonic nanostructures is always weak and difficult for dynamic adjustment. In this work, graphene sheets (GSs) are introduced in planar metal chiral split rings (MCSRs) to enhance and dynamically adjust their CD effect. Read More

J Neurosurg Pediatr 2021 Jun 11:1-7. Epub 2021 Jun 11.

1Department of Neurosurgery, Boston Children's Hospital.

Objective: The goal in this study was to outline unique differences between radiation-induced and nonradiation-induced pediatric meningiomas and to identify independent risk factors of tumor recurrence/progression.

Methods: This is a retrospective cohort study of all pediatric meningiomas diagnosed and surgically treated at the authors' institution between 1993 and 2017. Multivariable Cox regression was applied to identify independent risk factors for tumor recurrence/progression. Read More

J Neurosurg Spine 2021 Jun 11:1-9. Epub 2021 Jun 11.

2Neurosurgery, and.

Objective: The aim of this study was to investigate cerebral reorganization, both structurally and functionally, occurring in patients with degenerative cervical myelopathy (DCM) after surgical decompression.

Methods: In the current observational study of 19 patients, high-resolution T1-weighted structural MRI and resting-state functional MRI scans were obtained pre- and postoperatively in patients with DCM and healthy controls (HCs). The resting-state functional MRI data were utilized to perform region-of-interest (ROI)-to-ROI and ROI-to-voxel functional connectivity (FC) analysis and were similarly compared between and within cohorts. Read More

J Neurosurg Spine 2021 Jun 11:1-8. Epub 2021 Jun 11.

1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Objective: Although fellowship training is becoming increasingly common in neurosurgery, it is unclear which factors predict an academic career trajectory among spinal neurosurgeons. In this study, the authors sought to identify predictors associated with academic career placement among fellowship-trained neurological spinal surgeons.

Methods: Demographic data and bibliometric information on neurosurgeons who completed a residency program accredited by the Accreditation Council for Graduate Medical Education between 1983 and 2019 were gathered, and those who completed a spine fellowship were identified. Read More

Tissue Cell 2021 Jun 8;72:101573. Epub 2021 Jun 8.

Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, PR China. Electronic address:

Intestinal microvascular endothelial cell (IMVEC) is a fundamental and essential component of gut-vascular barrier which is closely associated with intestinal disorders However, there is still a lack of established intestinal microvascular endothelial cell line. In the present study, a newly established rat intestinal microvascular endothelial cell line termed RIMVEC-11 was described and characterized which has been stably cultured for more than 90 passages so far. RIMVEC-11 was characterized by endothelial features with the cobblestone morphology under light microscopy, the Weibel-Palade body and rich vesicles in the cytoplasm on the ultrastructural level, and positive endothelial specific markers CD31 and von Willebrand factor by immunocytochemistry analysis. Read More

J Vet Cardiol 2021 Apr 18;36:64-76. Epub 2021 Apr 18.

Indian Veterinary Research Institute, Regional Campus, Hebbal, Bengaluru, Karnataka, 560024, India.

Introduction: Foot-and-mouth disease (FMD) causes mortality in calves due to myocarditis; however, the effects of FMD virus on cardiac arrhythmogenesis and Purkinje cells are unknown. Identifying diagnostic and prognostic markers in FMD-affected calves may be useful in disease management in the endemic countries.

Materials And Methods: A total of 81 FMD-affected calves were prospectively monitored till death or recovery. Read More

Sci Total Environ 2021 Jun 3;791:148252. Epub 2021 Jun 3.

Universidad de Granada, Campus de Cartuja, s/n, 18071 Granada, Spain.

In the current pandemic context, it is necessary to remember the lessons learned from previous outbreaks in Africa, where the incidence of other diseases could rise if most resources are directed to tackle the emergency. Improving the access to water, sanitation and hygiene (WASH) could be a win-win strategy, because the lack of these services not only hampers the implementation of preventive measures against SARS-CoV-2 (e.g. Read More

Health Place 2021 Jun 8;70:102587. Epub 2021 Jun 8.

Department of Global Community Health and Behavioral Sciences, Tulane University School of Public Health and Tropical Medicine, 1440 Canal St, New Orleans, LA, 70112, USA.

Depression is a common comorbidity among Black women with systemic lupus erythematosus (SLE), an understudied autoimmune disease characterized by major racial and gender inequities. Research is needed that examines how area-level factors influence risk of depression in this population. Latent profile analysis revealed four neighborhood typologies among metropolitan Atlanta, Georgia census tracts that participants (n=438) in the Black Women's Experiences Living with Lupus (BeWELL) Study were living in: Integrated/High-SES, Moderately Segregated/Mid-SES, Highly Segregated/Mid-SES, and Highly Segregated/Low-SES. Read More

Food Chem 2021 Jun 3;363:130275. Epub 2021 Jun 3.

Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada. Electronic address:

Fermentation is an effective non-thermal food processing operation used for enhancing the nutritional and functional properties of food. HPLC-ESI-MS/MS analysis and inhibitory capacity of the soluble- and insoluble-bound phenolics in lentil hulls in retarding the oxidation of LDL and DNA strand scission were determined following fermentation. In HPLC-ESI-MS/MS analysis, most insoluble-bound phenolics in lentil hulls were significantly decreased, indicating their liberation from the cell wall matrix upon fermentation. Read More

J Stroke Cerebrovasc Dis 2021 Jun 8;30(8):105894. Epub 2021 Jun 8.

Unidad de Neurología Vascular, Servicio de Neurología, Departamento de Neurología y Psiquiatría, Clínica Alemana de Santiago, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Chile; Unidad de Neurología Vascular, Servicio de Neurología, Departamento de Neurología y Psiquiatría y Departamento de Paciente Critico, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.

Objectives: In-hospital acute ischemic stroke (HIS) accounts for 2-17% of all acute ischemic strokes (AIS) seen in hospital and they have worse prognosis. In this study we aimed to identify the frequency of HIS and their characteristics in our center.

Materials And Methods: Retrospective analysis of a prospective register of patients with AIS seen at Clínica Alemana de Santiago, between January 2017 and January 2019. Read More

J Stroke Cerebrovasc Dis 2021 Jun 8;30(8):105755. Epub 2021 Jun 8.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, 400042 Chongqing, China. Electronic address:

Objective: The aim of the present study was to determine whether there is a correlation between thrombotic pathology and prognosis of endovascular treatment (EVT) for acute ischemic stroke (AIS).

Methods: Thrombi were taken from 58 patients with cerebral ischemic thrombosis who were consecutively selected for EVT for AIS. The collected thrombi then underwent hematoxylin-eosin staining for pathological examinations to determine the red blood cell (RBC) ratio and fibrin/platelet components. Read More