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Long-term functional and clinical outcomes following transanal advancement flap for complex anal fistula repair. are there predictors of recurrence and incontinence?

Colorectal Dis 2020 Jul 12. Epub 2020 Jul 12.

Colorectal Unit, Department of General and Digestive Surgery, Arnau de Vilanova Hospital, Valencia, Spain.

Aim: Transanal flap is an attractive technique for complex fistulas.The aim of this study is to identify factors associated with poor outcome, recurrence and incontinence.

Method: All patients who underwent an advancement flap for the treatment of complex anal fistulas between 1995 and 2019 were prospectively enrolled. Read More

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http://dx.doi.org/10.1111/codi.15251DOI Listing

Factors contributing to clinician training and development in the clinical area of laryngectomy and tracheoesophageal voice.

Int J Lang Commun Disord 2020 Jul 12. Epub 2020 Jul 12.

The University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, QLD, Australia.

Background: It has long been recognized that tracheoesophageal speech (TES) rehabilitation after laryngectomy is a specialized area of practice for speech and language therapist (SLTs) due to the complex nature of patient presentation and the invasive components of the SLT's role in this area. Therefore, postgraduate experience and training is required to work competently and safely in this clinical area. However, it is generally acknowledged that the steps and processes followed by individual clinicians to achieve this training and clinical skill development are inconsistent and vary widely across services. Read More

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http://dx.doi.org/10.1111/1460-6984.12553DOI Listing

Use of tocilizumab in kidney transplant recipients with COVID-19.

Am J Transplant 2020 Jul 12. Epub 2020 Jul 12.

Department of Nephrology, Hospital del Mar, Institute Mar for Medical Research, REDinREN (RD16/0009/0013), Barcelona, Spain.

Acute respiratory distress syndrome associated with coronavirus infection is related to a cytokine storm with large interleukin 6 (IL-6) release. The IL-6-receptor blocker tocilizumab may control the aberrant host immune response in COVID-19 patients. In this pandemic, kidney transplant (KT) recipients are a high-risk population for severe infection and showed poor outcomes. Read More

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http://dx.doi.org/10.1111/ajt.16192DOI Listing

Single-cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy.

Cancer Commun (Lond) 2020 Jul 12. Epub 2020 Jul 12.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.

Single-cell RNA sequencing (scRNA-seq) is a novel technology that allows transcriptomic analyses of individual cells. During the past decade, scRNA-seq sensitivity, accuracy, and efficiency have improved due to innovations including more sensitive, automated, and cost-effective single-cell isolation methods with higher throughput as well as ongoing technological development of scRNA-seq protocols. Among the variety of current approaches with distinct features, researchers can choose the most suitable method to carry out their research. Read More

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http://dx.doi.org/10.1002/cac2.12078DOI Listing

The 2018 Banff Working Group Classification of Definitive Polyomavirus Nephropathy: A Multi Center Validation Study in the Modern Era.

Am J Transplant 2020 Jul 11. Epub 2020 Jul 11.

Weill-Cornell Medical Center, New York Presbyterian Hospital, Department of Pathology, New York, NY, USA.

Polyomavirus nephropathy (PVN) remained inadequately classified until 2018 when the "Banff Working Group" published a new 3-tier morphologic classification scheme derived from in-depth statistical analysis of a large multinational patient cohort. Here we report a multicenter "modern era" validation study that included 99 patients with definitive PVN transplanted post 1/1/2009 and followed the original 2018 study design. Results validate the PVN classification, i. Read More

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http://dx.doi.org/10.1111/ajt.16189DOI Listing

A systematic review on reported outcomes and outcome measures in female idiopathic chronic pelvic pain for the development of a core outcome set.

BJOG 2020 Jul 12. Epub 2020 Jul 12.

Department of Obstetrics and Gynaecology, St Helier University Hospitals NHS Trust, Epsom &, London, KT18 7EG, United Kingdom.

Background: A core outcome set (COS) is required to address inconsistencies in outcome reporting in chronic pelvic pain (CPP) trials.

Objectives: Evaluation of reported outcomes and selected outcome measures in CPP trials by producing a comprehensive inventory to inform a COS.

Search Strategy: Systematic review of RCT identified from Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE and MEDLINE databases. Read More

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http://dx.doi.org/10.1111/1471-0528.16412DOI Listing

Pan-genome analysis of Streptococcus suis serotype 2 revealed genomic diversity among strains of different virulence.

Transbound Emerg Dis 2020 Jul 11. Epub 2020 Jul 11.

College of Veterinary Medicine, Nanjing Agricultural University, Key Lab of Animal Bacteriology, Ministry of Agriculture, OIE Reference Lab for Swine Streptococcosis, Nanjing, 210095, China.

Streptococcus suis (SS) is an emerging zoonotic pathogen that causes severe infections in swine and humans. Among the 33 known serotypes, serotype 2 is most frequently associated with infections in pigs and humans. To better understand the virulence characterization of S. Read More

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http://dx.doi.org/10.1111/tbed.13725DOI Listing

A pilot randomized controlled trial comparing online versus face-to-face delivery of an aphasia communication partner training program for student healthcare professionals.

Int J Lang Commun Disord 2020 Jul 12. Epub 2020 Jul 12.

The University of Sydney, Sydney, NSW, Australia.

Background: Training conversation partners of people with aphasia who use facilitative communication strategies is one method that can improve access to healthcare for people with aphasia. However, the efficacy of communication partner training (CPT) has been investigated almost exclusively in the context of face-to-face (F2F) delivery. Online training may offer more cost-effective and accessible options to a wider range of conversation partners, including student healthcare professionals. Read More

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http://dx.doi.org/10.1111/1460-6984.12556DOI Listing

Could medications and biologic factors affect post orthodontic tooth movement changes? a systematic review of animal studies.

Orthod Craniofac Res 2020 Jul 12. Epub 2020 Jul 12.

Department of Dentistry, European University Cyprus, Nicosia, Cyprus.

Background: Immediately after the removal of orthodontic appliances the teeth might start to drift away from their corrected position in an attempt to reach a new equilibrium. Medications and biologic factors could potentially modulate these processes.

Objective: To systematically investigate and appraise the quality of the evidence regarding the effect of various medications and biologic factors on the rate of relapse following active tooth movement. Read More

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http://dx.doi.org/10.1111/ocr.12411DOI Listing

Cancer-associated mutations in normal human endometrium: Surprise or expected?

Cancer Sci 2020 Jul 12. Epub 2020 Jul 12.

Department of Obstetrics and Gynecology, Shimane University, Faculty of Medicine, 89-1, Enya-Cho, Izumo, Shimane, 693-8501, Japan.

The human endometrium is an essential component in human reproduction that has the unique characteristic of undergoing cyclic regeneration during each menstrual cycle. Vigorous regeneration after shedding may be sustained by stem/progenitor cells, for which molecular markers have not been fully identified. Although clonality analysis using X chromosome inactivation patterns has shown that normal human endometrial glands are composed of a monoclonal cell population, whether clonal expansion is derived from stem/progenitor cells remains unclear. Read More

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http://dx.doi.org/10.1111/cas.14571DOI Listing

Diagnostic potential of presepsin in bacterial infection following hepato-biliary-pancreatic surgery: A prospective observational study.

J Hepatobiliary Pancreat Sci 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background/purpose: This study aims to elucidate the diagnostic ability of presepsin for postoperative infectious complications following major hepato-biliary-pancreatic (HBP) surgery.

Methods: Between 2017 and 2019, 50 patients with major hepatectomy and 55 patients with pancreatoduodenectomy were enrolled. Presepsin, the neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), and procalcitonin (PCT) were prospectively measured for the first 2 weeks after surgery. Read More

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http://dx.doi.org/10.1002/jhbp.802DOI Listing

First expert elicitation of knowledge on drivers of emergence of the COVID-19 in pets.

Transbound Emerg Dis 2020 Jul 11. Epub 2020 Jul 11.

Department for Occupational Protection and Hygiene, Unit Biosafety, Biosecurity and Environmental Licences, University of Liege, Liege, Belgium.

Infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) induces the coronavirus infectious disease 19 (COVID-19). Its pandemic form in human population and its probable animal origin, along with recent case reports in pets, make drivers of emergence crucial in domestic carnivore pets, especially cats, dogs and ferrets. Few data are available in these species; we first listed forty-six possible drivers of emergence of COVID-19 in pets, regrouped in eight domains (i. Read More

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http://dx.doi.org/10.1111/tbed.13724DOI Listing

Impaired myosin isoform shift and calcium transients contribute to cellular pathogenesis of rat cirrhotic cardiomyopathy.

Liver Int 2020 Jul 12. Epub 2020 Jul 12.

Liver Unit, Gastrointestinal Research Group, Department of Medicine, University of Calgary, Calgary, Canada.

Background & Aims: Cirrhotic cardiomyopathy is a recently recognized entity, but detailed cellular and molecular mechanisms remain unclarified. We aimed to elucidate the role of myosin heavy chain isoform shifts and their relation to calcium transients in the contractile kinetics of cirrhotic rats.

Methods: Cirrhosis was induced in male Lewis Brown-Norway rats by bile duct-ligation (BDL). Read More

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http://dx.doi.org/10.1111/liv.14599DOI Listing

Ecological specialization and niche overlap of subterranean rodents inferred from DNA metabarcoding diet analysis.

Mol Ecol 2020 Jul 12. Epub 2020 Jul 12.

Laboratoire d'Écologie Alpine, UMR 5553, Université Grenoble Alpes, CNRS, Université Savoie Mont Blanc, CNRS, F-38000, Grenoble, France.

Knowledge of how animal species use food resources available in the environment increases our understanding of ecological processes. However, obtaining this information using traditional methods is a hard task for species feeding on a large variety of food items in highly diverse environments. We amplified the DNA of plants for 306 scat and 40 soil samples, and applied an eDNA metabarcoding approach to investigate food preferences, degree of diet specialization and diet overlap of seven herbivore rodent species of the Ctenomys genus distributed in southern and midwestern Brazil. Read More

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http://dx.doi.org/10.1111/mec.15549DOI Listing

Comparative sequencing data analysis of Ion Torrent and MinION sequencing platforms using a clinical diagnostic haematology panel.

Int J Lab Hematol 2020 Jul 12. Epub 2020 Jul 12.

Paediatric Haematology-Oncology Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Currently, two second-generation sequencing platforms-Ion Torrent and Illumina are being widely used for clinical testing and reporting of human samples. However, third-generation long read platforms like single molecule (PacBio) or direct sequencing (Nanopore) are gaining widespread interest in clinical genomics.

Aims And Objectives: The current study attempts to analyse and compare MinION sequencing data with Ion Torrent data, using a haematology ampliseq panel, to shed light on its current standing in reporting of clinical diagnostic samples. Read More

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http://dx.doi.org/10.1111/ijlh.13286DOI Listing

High-resolution temporal dynamic transcriptome landscape reveals a GhCAL-mediated flowering regulatory pathway in cotton (Gossypium hirsutum L.).

Plant Biotechnol J 2020 Jul 12. Epub 2020 Jul 12.

College of Agronomy, Northwest A&F University, Yangling, 712100, Shaanxi, People's Republic of China.

The transition from vegetative to reproductive growth is very important for early maturity in cotton. However, the genetic control of this highly dynamic and complex developmental process remains unclear. A high-resolution tissue- and stage-specific transcriptome profile was generated from six developmental stages using 72 samples of two early-maturing and two late-maturing cotton varieties. Read More

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http://dx.doi.org/10.1111/pbi.13449DOI Listing

Sonographic detection of physiological lower leg edema in the late afternoon in healthy young women.

Clin Physiol Funct Imaging 2020 Jul 12. Epub 2020 Jul 12.

Kyorin University School of Medicine, Tokyo, Japan.

Lower leg edema occurs physiologically in the evening after daytime activity. Various edema-related sonographic findings have recently been reported, but this physiological edema has not been evaluated quantitatively using imaging examinations. The present study investigated whether sonography could detect physiological lower leg edema, comparing measured values between the morning and late afternoon. Read More

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http://dx.doi.org/10.1111/cpf.12654DOI Listing

Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.

J Anim Breed Genet 2020 Jul 12. Epub 2020 Jul 12.

Embrapa Cerrados, Brasilia, Brazil.

The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for these traits. Read More

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http://dx.doi.org/10.1111/jbg.12496DOI Listing

Serum long non-coding RNA LINC00887 as a potential biomarker for diagnosis of renal cell carcinoma.

FEBS Open Bio 2020 Jul 12. Epub 2020 Jul 12.

Center of Clinical Laboratory, First medical center of Chinese, PLA General Hospital, Beijin, 100853, China.

The identification of non-invasive biomarkers for detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long noncoding RNAs (lncRNAs) have been reported to be possible biomarkers for diagnosis and prognosis of cancer. Here, we examined the suitability of the lncRNA LINC00887 as a potential biomarker for RCC, as its expression has been shown to be elevated in RCC tissue versus normal tissue in the Gene Expression Profiling Interactive Analysis (GEPIA) database. Read More

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http://dx.doi.org/10.1002/2211-5463.12930DOI Listing

Complications After Open and Robotic-Assisted Radical Prostatectomy and Association with Post-Operative Opioid Use: An Analysis of Data from the PREVENTER Trial.

BJU Int 2020 Jul 12. Epub 2020 Jul 12.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Objective: To evaluate perioperative complications for open and robotic-assisted RP for patients enrolled in the PREVENTER trial to determine predictors and impact on opioid consumption.

Patients And Methods: A prospective cohort of 500 patients undergoing open and robotic-assisted RP were followed to determine rates of complications and opioid use. Complications were classified 30 days post-RP using the Clavien-Dindo system. Read More

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http://dx.doi.org/10.1111/bju.15172DOI Listing

Socioeconomic disparities in the utilization of spinal cord stimulator therapy in chronic pain patients.

Pain Pract 2020 Jul 11. Epub 2020 Jul 11.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Objectives: Spinal cordstimulator (SCS) therapies are used in the management of patients with complex regional pain syndrome I (CRPS I) and failed back surgery syndrome (FBSS). The purpose of this study is to investigate the racial and health insurance inequalities with SCS therapy in chronic pain patients with CRPS I and FBSS.

Materials And Methods: Chronic pain patients with a discharge diagnosis of FBSS and CRPS I were identified with the National Inpatient Sample (NIS) database. Read More

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http://dx.doi.org/10.1111/papr.12936DOI Listing

Risk scores for occult cancer in patients with unprovoked venous thromboembolism: results from an individual patient data meta-analysis.

J Thromb Haemost 2020 Jul 12. Epub 2020 Jul 12.

Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.

Background: The RIETE and SOME risk scores aim to identify patients with acute unprovoked venous thromboembolism (VTE) at high risk of occult cancer, but their predictive performance is unclear.

Methods: The scores were evaluated in an individual-patient data meta-analysis. Studies were eligible if enrolling consecutive adults with unprovoked VTE who underwent protocol-mandated screening for cancer. Read More

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http://dx.doi.org/10.1111/jth.15001DOI Listing

Low phosphorus supply constrains plant responses to elevated CO : a meta-analysis.

Glob Chang Biol 2020 Jul 12. Epub 2020 Jul 12.

Hawkesbury Institute for the Environment, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.

Phosphorus (P) is an essential macro-nutrient required for plant metabolism and growth. Low P availability could potentially limit plant responses to elevated carbon dioxide (eCO ), but consensus has yet to be reached on the extent of this limitation. Here, based on data from experiments that manipulated both CO and P for young individuals of woody and non-woody species, we present a meta-analysis of P limitation impacts on plant growth, physiological, and morphological response to eCO . Read More

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http://dx.doi.org/10.1111/gcb.15277DOI Listing

Clinical Characteristics and Outcomes of COVID-19 in Solid Organ Transplant Recipients: A Case-Control Study.

Am J Transplant 2020 Jul 12. Epub 2020 Jul 12.

Division of Infectious Diseases, Henry Ford Hospital, Detroit, MI, USA.

Solid organ transplant recipients (SOTr) with COVID-19 are expected to have poorer outcomes compared to non-transplant patients due to immunosuppression and comorbidities. The clinical characteristics of 47 SOTr (38 kidneys and 9 non-kidney organs) were compared to 100 consecutive hospitalized non-transplant controls. 12/47 SOTr managed as outpatients were subsequently excluded from the outcome analyses to avoid potential selection bias. Read More

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http://dx.doi.org/10.1111/ajt.16188DOI Listing

Primary melanotic tumors of the nervous system: a consecutive case series.

Eur J Neurol 2020 Jul 12. Epub 2020 Jul 12.

Department of Neurology, Yale School of Medicine, New Haven, CT, United States.

Background: Primary melanotic tumors of the nervous system (PMTNS) are thought to be an exceedingly rare group of tumors not captured by tumor registries. We aimed to determine relative incidence, clinical presentation, diagnostic findings, patient management, and outcome.

Methods: We retrospectively searched the database of the Section of Neuro-Oncology, Yale Cancer Center for patients with primary or metastatic melanotic lesions of the nervous system. Read More

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http://dx.doi.org/10.1111/ene.14437DOI Listing

Prospective Evaluation of ISTH-BAT as a Predictor of Bleeding Disorder in Adolescents Presenting with Heavy Menstrual Bleeding in a Multidisciplinary Hematology Clinic.

J Thromb Haemost 2020 Jul 12. Epub 2020 Jul 12.

Department(s) of Pediatrics, Division of Hematology/Oncology, Children's Medical Center, The University of Texas Southwestern Medical Center, TX, Pathology and Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Dallas, TX, United States.

Background: Heavy menstrual bleeding (HMB) can be the first manifestation of an undiagnosed bleeding disorder (BD). Identifying a BD can be challenging in the adolescent age group. The utility of bleeding assessment tools (BAT) remains elusive in this population. Read More

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http://dx.doi.org/10.1111/jth.14997DOI Listing

Effect of patient characteristics on reported outcomes over 12 months following lumbar radiofrequency ablation: a retrospective review of 500 patients.

Pain Pract 2020 Jul 12. Epub 2020 Jul 12.

The Spine and Nerve Center of the Virginias, 400 Court Street, Suite 100, Charleston, WV, USA.

Background: Low back pain is the leading cause of years lost to disability worldwide. Approximately 15-45% of chronic low back pain is due to facet joint arthropathy. Currently, there are no large-scale retrospective studies that investigate long-term clinical predictors of success in individuals receiving radiofrequency ablation (RFA) of the medial branches for facet joint arthropathy. Read More

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http://dx.doi.org/10.1111/papr.12938DOI Listing

Evaluation of pentoxifylline and Basal Medium Eagle supplemented to diluent on cryopreserved goat spermatozoa.

Reprod Domest Anim 2020 Jul 12. Epub 2020 Jul 12.

Laboratory of Reproduction Biology, Department of Animal Science, University of Kurdistan, Sanandaj, Kurdistan, Iran.

This study investigated the effect of pentoxifylline (PTX) and Basal Medium Eagle (BME) on frozen-thawed goat spermatozoa. Immediately after initial examination of ejaculated semen, samples were pooled and reexamined for quality. Then, samples were divided into eight equal aliquots and diluted with a basic tris-extender containing PTX (3, 6, 9 mM) and BME (5 mM) to reach a final concentration of 25x10 and frozen. Read More

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http://dx.doi.org/10.1111/rda.13774DOI Listing

PARP inhibitors as maintenance therapy in newly diagnosed advanced ovarian cancer: A meta-analysis.

BJOG 2020 Jul 12. Epub 2020 Jul 12.

Department of Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Background: Up to 70% of the patients with advanced ovarian cancer have a relapse after primary therapy. New agents and approaches are urgently needed to avoid or slow down the reccurence.

Objectives: To investigate the efficacy of PARP inhibitors (PARPis) as maintenance treatment in patients with newly diagnosed advanced ovarian cancer. Read More

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http://dx.doi.org/10.1111/1471-0528.16411DOI Listing

Korean Nurses' Participation in Healthcare Policy Reform: A Phenomenological Study.

Authors:
NamKyung Han

J Nurs Manag 2020 Jul 12. Epub 2020 Jul 12.

Executive of Korean Aging Friendly Industry Association, Gimhae, South Korea.

Aim: This study aimed to explore the healthcare policy reform activities of Korean nurses engaged in civic organizations.

Background: Nursing professionals must lead healthcare policy reforms to create a healthcare environment that improves public health outcomes as the change in population and disease structure accelerates.

Methods: Using Colaizzi's phenomenological analysis, this study conducted in-depth interviews with seven Korean civic-activists nurses who had led successful healthcare policy reforms through policy interventions. Read More

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http://dx.doi.org/10.1111/jonm.13088DOI Listing

Global declines in human-driven mangrove loss.

Glob Chang Biol 2020 Jul 12. Epub 2020 Jul 12.

Biospheric Sciences Laboratory, NASA Goddard Space Flight Center, 8800 Greenbelt Road, Greenbelt, MD, USA.

Global mangrove loss has been attributed primarily to human activity. Anthropogenic loss hotspots across Southeast Asia and around the world have characterized the ecosystem as highly threatened, though natural processes such as erosion can also play a significant role in forest vulnerability. However, the extent of human and natural threats has not been fully quantified at the global scale. Read More

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http://dx.doi.org/10.1111/gcb.15275DOI Listing

Paediatricians' practices and knowledge of corticosteroids: a national survey.

Acta Paediatr 2020 Jul 12. Epub 2020 Jul 12.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Aim: To explore corticosteroid prescription practices and knowledge among paediatricians.

Methods: The Paediatricians Corticosteroids Survey, a cross-sectional, web-based survey distributed to Israeli paediatricians between February-July 2018.

Results: Three hundred and forty-nine paediatricians (105 general paediatricians, 207 subspecialists, and 37 paediatric endocrinologists) participated. Read More

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http://dx.doi.org/10.1111/apa.15481DOI Listing

Synaptic organization of cortico-cortical communication in primates.

Eur J Neurosci 2020 Jul 12. Epub 2020 Jul 12.

Complex Systems and Computational Neuroscience Group, Department of Computational Sciences, Wigner Research Centre for Physics, Budapest, Hungary.

In cortical circuitry synaptic communication across areas is based on two types of axon terminals, small and large, with modulatory and driving roles, respectively. In contrast, it is not known whether similar synaptic specializations exist for intra-areal projections. Using anterograde tracing and three-dimensional reconstruction by electron microscopy (3D-EM) we asked if large boutons form synapses in the circuit of somatosensory cortical areas 3b and 1. Read More

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http://dx.doi.org/10.1111/ejn.14905DOI Listing

Efficacy of combination therapy of narrowband-ultraviolet B phototherapy or excimer laser with topical tacrolimus for vitiligo: An updated systematic review and meta-analysis.

Photodermatol Photoimmunol Photomed 2020 Jul 12. Epub 2020 Jul 12.

Department of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.

Vitiligo is a common chronic cutaneous depigmentation disorder for which both topical tacrolimus and phototherapy are well-established treatments. Previous meta-analyses have reported conflicting results for repigmentation after topical tacrolimus combined with phototherapy with narrowband-ultraviolet B (NB-UVB) or excimer laser compared with phototherapy alone. Various studies have been published since then. Read More

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http://dx.doi.org/10.1111/phpp.12593DOI Listing

Comparative study of impact of animal source on physical, structural, and biological properties of bone xenograft.

Xenotransplantation 2020 Jul 12:e12628. Epub 2020 Jul 12.

Nova Teb Research Laboratory, Dental Equipment and Biomaterials Incubation Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Due to the unique features of xenografts including large supply from donors, minimal risk of human disease transmission, and the lower cost of preparation and production compared to autografts and allografts, they are considered as attractive alternatives to traditional bone grafts. The animal source accessibility and production process have a direct correlation with the cost and quality of the final product. To evaluate whether the animal source of the bone has any effect on the physicochemical and histological properties of the final xenograft, three deproteinized bone grafts were prepared from sources that are easily available in Iran, including the bovine (DBB), camel (DCB), and ostrich (DOB). Read More

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http://dx.doi.org/10.1111/xen.12628DOI Listing

Validation of the Warwick-Edinburgh Mental Well-being Scale among nursing students in Slovenia.

J Nurs Manag 2020 Jul 12. Epub 2020 Jul 12.

University of Maribor, Faculty of Health Sciences, Žitna ulica 15, 2000, Maribor, Slovenia.

Aim: The aim of this study was to assess the validity of the Warwick-Edinburgh Mental Well-being Scale used for measuring mental well-being.

Background: Nursing students' mental well-being is often poor due to various academic and personal stressors. Nursing students are involved in clinical practice and are facing birth, death, health, diseases, and other stressful situations. Read More

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http://dx.doi.org/10.1111/jonm.13087DOI Listing

Are the evaluation criteria used in preclinical endodontic training courses relevant? A preliminary study.

Aust Endod J 2020 Jul 12. Epub 2020 Jul 12.

Department of Restorative Dentistry and Endodontics, Faculty of Odontology, Université de Lille, Lille, France.

This study aimed to evaluate the relevance of a conventional evaluation protocol (CEP) for preclinical endodontic training. Seven dental students performed root canal treatments on an extracted human molar which was then evaluated by CEP (clinical and radiographic observations, including preparing the access cavities, preparing and filling the root canal, and detecting iatrogenic errors). A reference evaluation protocol (REP) based on micro-computed tomographic images analysis was used as a control. Read More

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http://dx.doi.org/10.1111/aej.12417DOI Listing

Long intergenic non-coding RNA 00337 confers progression of esophageal cancer by mediating microrna-145-dependent fscn1.

FASEB J 2020 Jul 12. Epub 2020 Jul 12.

Infectious Diseases Clinic, Linyi People's Hospital, Linyi, P.R. China.

Long non-coding RNAs (lncRNAs) have been highlighted as prominent genetic modulators involved in multiple important biological processes of cancer cells, especially in esophageal cancer (EC). We tried to elucidate the potential role of LINC00337 in the progression of EC. Based on TCGA database analysis and Reverse transcription quantitative polymerase chain reaction determination, high expression of LINC00337 and FSCN1 was detected, while miR-145 exhibited a low expression in EC. Read More

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http://dx.doi.org/10.1096/fj.202000470DOI Listing

High Mass Resolution, Spatial Metabolite Mapping Enhances the Current Plant Gene and Pathway Discovery Toolbox.

New Phytol 2020 Jul 12. Epub 2020 Jul 12.

Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 761001, Israel.

Understanding when and where metabolites accumulate provides important cues to the gene function. Mass Spectrometry Imaging (MSI) enables in situ temporal and spatial measurement of a large assortment of metabolites, providing mapping information regarding their cellular distribution. To describe the current state and technical advances of using MSI in plant sciences, we employed MSI to demonstrate its significant contribution to the study of plant specialized metabolism. Read More

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http://dx.doi.org/10.1111/nph.16809DOI Listing

Premature graying of hair: Risk factors, co-morbid conditions, pharmacotherapy and reversal: A systematic review and meta-analysis.

Dermatol Ther 2020 Jul 11:e13990. Epub 2020 Jul 11.

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Premature graying of hair (PGH) being a very common entity for which pharmacotherapy and reversibility are not properly addressed. Therefore, this systematic review was conducted to address these issues. For this relevant study were selected from various databases including PubMed, EMBASE, OVID, Web of science, Scopus and Google Scholar till January 20, 2019. Read More

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http://dx.doi.org/10.1111/dth.13990DOI Listing

Changes in ocular biometry during short-term accommodation in children.

Ophthalmic Physiol Opt 2020 Jul 12. Epub 2020 Jul 12.

Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.

Purpose: Near work has been linked with myopia development; however, the underlying mechanism remains unclear. Small increases in axial length during accommodation have previously been reported in adults, and therefore, this study aimed to examine if accommodation-induced changes in ocular biometry also occur in school-aged children.

Methods: A range of ocular biometric measurements were captured during brief accommodation tasks at four demands (0, 3, 6, and 9 D), in a group of 87 non-myopic, school-aged children using a Badal optometer mounted to a non-contact optical biometer (Zeiss IOLMaster 700, https://www. Read More

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http://dx.doi.org/10.1111/opo.12711DOI Listing

A low protein maternal diet during gestation has negative effects on male fertility markers in rats - A Systematic Review and Meta-analysis.

J Anim Physiol Anim Nutr (Berl) 2020 Jul 12. Epub 2020 Jul 12.

School of Science and Technology, University of New England, Armidale, NSW, Australia.

Research indicates that some adult diseases including reproductive pathologies are programmed in utero during foetal development. In particular, maternal low dietary protein, during the most critical developmental periods of male foetal development, may have a detrimental impact on male fertility through direct and epigenetic mechanisms. The aim of our study was to evaluate the impact of a gestational low protein diet on fertility markers in male offspring in rats through a systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1111/jpn.13411DOI Listing

Relapse-Related Molecular Signature in early stage Lung Adenocarcinomas based on BER, STING pathway and TILs.

Cancer Sci 2020 Jul 12. Epub 2020 Jul 12.

Cancer Center, Daping Hospital & Army Medical Center of PLA, Third Military Medical University(Army Medical University), Chongqing, 400042, China.

Approximately 30% of patients with early stage NSCLC relapse within 5 years after surgery. Therefore, it is necessary to identify a robust and reliable prognostic signature for early stage NSCLC. Immunohistochemistry data from 147 patients with stage I lung adenocarcinoma (stage I-LUAD) were analyzed for the protein expression of base excision repair (BER), stimulator of interferon genes (STING) and tumor-infiltrating lymphocytes (TILs) to explore the relationship between protein expression and prognosis. Read More

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http://dx.doi.org/10.1111/cas.14570DOI Listing

Experiences following cataract surgery - patient perspectives.

Ophthalmic Physiol Opt 2020 Jul 11. Epub 2020 Jul 11.

School of Optometry and Vision Science, University of Bradford, West Yorkshire, UK.

Purpose: Most patients report being highly satisfied with the outcome of cataract surgery but there are variable reports regarding the impact of cataract surgery on some real-world activities, such as fall rates. We hypothesised that adaptations to changed refractive correction and visual function may cause difficulties in undertaking everyday activities for some patients and used a series of focus groups to explore this issue.

Method: Qualitative methods were used to explore patients' experiences of their vision following cataract surgery, including adaptation to vision changes and their post-surgical spectacle prescription. Read More

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http://dx.doi.org/10.1111/opo.12709DOI Listing

Improving Follow-Up Attendance for Discharged Emergency Care Patients Using Automated Phone System to Self-Schedule: A Randomized Controlled Trial.

Acad Emerg Med 2020 Jul 11. Epub 2020 Jul 11.

School of Medicine, Department of Emergency Medicine, Washington University, Saint Louis, Missouri, United States.

Background: Automated phone appointment reminders have improved adherence with follow-up appointments in a variety of hospital settings, but have mixed results in patients discharged from the emergency department (ED). Increasing adherence to follow-up care has been a priority in the ED to improve patient outcomes and reduce unnecessary future visits.

Methods: We conducted a prospective randomized open, blinded end-point (PROBE) trial of 278 adult patients discharged from the ED and referred to a provider for follow-up care. Read More

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http://dx.doi.org/10.1111/acem.14080DOI Listing

Erlotinib for Non-Small Cell Lung Cancer with Leptomeningeal Metastases: A Phase II Study (LOGIK1101).

Oncologist 2020 Jul 12. Epub 2020 Jul 12.

Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.

Lessons Learned: This phase II trial evaluated the efficacy of erlotinib for patients with non-small cell lung cancer with leptomeningeal metastasis. The 17 cerebrospinal fluid specimens that were available for epidermal growth factor receptor mutation analysis were all negative for the resistance-conferring T790M mutation. The cytological objective clearance rate was 30. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0640DOI Listing

Dermatoscopic features of thin (≤ 2mm Breslow thickness) versus thick (> 2mm Breslow thickness) nodular melanoma and predictors of nodular melanoma versus nodular non-melanoma tumors: a multicentric collaborative study by the International Dermoscopy Society.

J Eur Acad Dermatol Venereol 2020 Jul 12. Epub 2020 Jul 12.

1st Department of Dermatology-Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.

Background: Thin nodular melanoma (NM) often lacks conspicuous melanoma-specific dermatoscopic criteria, and escapes clinical detection until it progresses to a thicker and more advanced tumor.

Objective: To investigate the dermatoscopic morphology of thin (≤2mm Breslow thickness) versus thick (>2mm) NM and to identify dermatoscopic predictors of its differential diagnosis from other nodular tumors.

Methods: Retrospective, morphological case-control study, conducted on behalf of the International Dermoscopy Society. Read More

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http://dx.doi.org/10.1111/jdv.16815DOI Listing

Impact of neutropenia evaluated in terms of the D-index on invasive fungal disease while on empiric or preemptive antifungal treatment strategy in the early phase after allogeneic hematopoietic stem cell transplantation.

Transpl Infect Dis 2020 Jul 11:e13409. Epub 2020 Jul 11.

Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan.

Background: We retrospectively evaluated the association between the D-index, which reflects both the depth and duration of neutropenia, and proven/probable invasive fungal disease (IFD) early after allogeneic hematopoietic stem cell transplantation (HSCT) at our center (n=394).

Methods: The D-index was defined as the area over the neutrophil curve during neutropenia. The cumulative D-index from the start of neutropenia until the development of infection (c-D-index) was also evaluated as a real-time assessment of neutropenia. Read More

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http://dx.doi.org/10.1111/tid.13409DOI Listing

Static Computer-Aided, Partially Guided and Free-Handed Implant Placement: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Clin Oral Implants Res 2020 Jul 12. Epub 2020 Jul 12.

Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA, USA.

Objective: To analyze the outcomes of static computer-aided implant placement (sCAIP) compared to partially guided (PGIP) and free-handed (FHIP) implant placement.

Material And Methods: This study was registered in PROSPERO (CRD42019131397). A comprehensive literature search was performed by two independent examiners. Read More

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http://dx.doi.org/10.1111/clr.13635DOI Listing

Whole genome sequencing identifies missense mutation in GRM6 as the likely cause of congenital stationary night blindness in a Tennessee Walking Horse.

Equine Vet J 2020 Jul 12. Epub 2020 Jul 12.

Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, California, 95616, USA.

Background: The only known genetic cause of congenital stationary night blindness (CSNB) in horses is a 1378 bp insertion in TRPM1. However, an affected Tennessee Walking Horse was found to have no copies of this variant.

Objectives: To identify the genetic cause for CSNB in an affected Tennessee Walking Horse. Read More

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http://dx.doi.org/10.1111/evj.13318DOI Listing
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