7,845,539 results match your criteria Analysis And Applications[Journal]

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Disordered APC/C-mediated cell cycle progression and IGF1/PI3K/AKT signalling are the potential basis of Sertoli cell-only syndrome.

Andrologia 2019 Apr 17:e13288. Epub 2019 Apr 17.

Institute of Reproductive & Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.

The cause of Sertoli cell-only syndrome (SCOS), a condition in which only Sertoli cells line the seminiferous tubules in the testis, is unknown. Three microarray data sets were downloaded from public databases and were used to compare SCOS and control group. A total of 291 genes differentially expressed (Log |FC| ≥ 1 and adjusted p value < 0. Read More

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http://dx.doi.org/10.1111/and.13288DOI Listing

Rare case of an oligospermic male with 46,XX/46,XY tetragametic chimerism.

Andrologia 2019 Apr 17:e13290. Epub 2019 Apr 17.

Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Chimerism, a rare human disorder, is assumed to be the result of an amalgamation of two separate zygotes in a single embryo. Studies have shown that the phenotypic spectrum of chimerism is variable and there is no definite genotype-phenotype correlation in patients with chimerism, therefore a majority of cases might remain undiagnosed. This study aims to investigate the possible mechanism of the chimerism in a 46,XX/46,XY infertile and phenotypically normal male, with 46,XX blood karyotype and normal spermatogenesis. Read More

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http://dx.doi.org/10.1111/and.13290DOI Listing

Digital vs face-to-face information provision in patient counselling for prenatal screening: a noninferiority randomized controlled trial.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

VU University Amsterdam, Athena Institute for Trans-Disciplinary Research, the Netherlands.

Objective: To evaluate face-to-face information provision in patient counselling for prenatal screening compared to two forms of digital information provision, namely non-interactive instructional video or interactive video.

Method: We performed a prospective, non-inferiority, cluster-randomized controlled trial comparing face-to-face (usual care) to two forms of digital information provision (intervention) in counselling for prenatal screening. This study was performed in the Amsterdam UMC, the Netherlands in 2017, and included women in the first trimester of pregnancy. Read More

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http://dx.doi.org/10.1002/pd.5463DOI Listing

Gaming National Emergency Access Target performance using Emergency Treatment Performance definitions and emergency department short stay units.

Emerg Med Australas 2019 Apr 17. Epub 2019 Apr 17.

Sax Institute, Sydney, New South Wales, Australia.

Objective: To evaluate potential gaming of the 4 h ED length of stay metric known as the National Emergency Access Target (NEAT) in Australia and Emergency Treatment Performance (ETP) in New South Wales (NSW).

Methods: Descriptive statistical analysis was used to recalculate and compare the scores for NEAT and the NSW ETP using variations in the definitions of their measurement on 32 184 presentations during 2016. A computer simulation using a discrete event model illustrated the effect of the use of ED short stay beds on the ETP scores. Read More

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http://dx.doi.org/10.1111/1742-6723.13295DOI Listing

[The Stepwise Care of Very Low Birth Weight Infants in Germany and Internationally].

Z Geburtshilfe Neonatol 2019 Apr 17. Epub 2019 Apr 17.

Kompetenz-Centrum Qualitätssicherung / Qualitätsmanagement, MDK Baden-Württemberg, Stuttgart.

Objective: In Germany the care of newborn infants is regulated by directives of the Federal Joint Committee. Assignment to the four levels of care, with level 1 being the highest level, is based on maternal risk factors, maternal and fetal diseases, birth weight and gestational age. This article compares birth weight and gestational age limits used in Germany with international regulations. Read More

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http://dx.doi.org/10.1055/a-0868-2513DOI Listing

Evaluating the Effect of Monitoring through Telephone (Tele-Monitoring) on Self-Care Behaviors and Readmission of Patients with Heart Failure after Discharge.

Appl Clin Inform 2019 Mar 17;10(2):261-268. Epub 2019 Apr 17.

Department of Nursing & Emergency Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Background:  Heart failure is one of the serious cardiovascular diseases, which poses a global pandemic and places a heavy burden on health care systems worldwide. The incidence of this disease in Iran is higher than in other Asian countries. To reduce patients' complications, readmission rates, and health care expenditures, it is necessary to design interventions, which are culturally appropriate and based on community needs. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685167
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http://dx.doi.org/10.1055/s-0039-1685167DOI Listing
March 2019
2 Reads

The combination of 13N-ammonia and 18F-FDG PET/CT in the identification of metabolic phenotype of primary human brain tumors.

Nuklearmedizin 2019 Apr 17. Epub 2019 Apr 17.

Department of Nuclear Medicine, the First Affiliated Hospital of Sun Yat-Sen University.

Aim: This pilot study made a preliminary attempt to distinguish different metabolic phenotypes of primary human brain tumors with dual tracer N-ammonia and F-FDG.

Methods: 74 patients were included in this study including 12 benign meningiomas (B-MEN), 4 malignant meningiomas (M-MEN), 15 low-grade gliomas (LGG), 32 high-grade gliomas (HGG) and 11 primary central nervous system lymphomas (PCNSL). All patients underwent N-ammonia and F-FDG PET imaging. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0835-5746
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http://dx.doi.org/10.1055/a-0835-5746DOI Listing
April 2019
1 Read

Outcome of inter-hospital transfer of patients on extracorporeal membrane oxygenation in Switzerland.

Swiss Med Wkly 2019 Apr 17;149:w20054. Epub 2019 Apr 17.

Clinic for Cardiovascular Surgery, University Heart Centre, Zurich, Switzerland.

Aims Of The Study: An extracorporeal membrane oxygenation system (ECMO), as a bridge to either recovery, a ventricular assist device (VAD), or heart or lung transplantation, may be the only lifesaving option for critically ill patients suffering from refractory cardiac, respiratory or combined cardiopulmonary failure. As peripheral hospitals may not offer ECMO treatment, tertiary care centres provide specialised ECMO teams for on-site implantation and subsequent patient transfer on ECMO to the tertiary hospital. This study reports the results of the largest ECMO transportation programme in Switzerland and describes its feasibility and safety. Read More

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http://dx.doi.org/10.4414/smw.2019.20054DOI Listing

Effect of Postoperative Radiotherapy for Brain Metastases: An Analysis.

Oncol Res Treat 2019 Apr 17;42(5):253-259. Epub 2019 Apr 17.

Department of Radiation Oncology, University Hospital Münster, Münster, Germany.

Introduction: Brain metastases (BM) have a very poor prognosis, creating a demand for effective local therapies, such as radiotherapy (RT) and neurosurgery, the combination of which is debatable. The aim of the present study was to investigate prognostic factors and to develop treatment recommendations for patients with BM.

Material And Methods: A total of 84 patients treated between May 2011 and July 2016 were analyzed in a single-institution retrospective study. Read More

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https://www.karger.com/Article/FullText/499323
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http://dx.doi.org/10.1159/000499323DOI Listing
April 2019
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Patient Attitude towards Videodermatoscopy for the Detection of Skin Cancer: A Cross-Sectional Study.

Oncol Res Treat 2019 Apr 17:1-6. Epub 2019 Apr 17.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany,

Background: Videodermatoscopy (VD) is a useful device for supporting dermatologists in the distinction between benign and malignant lesions. However, only few patients have access to VD in daily practice.

Objectives: To investigate patient attitudes towards VD. Read More

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http://dx.doi.org/10.1159/000499630DOI Listing

Clinical Experience of Immunotherapy Treatment: Efficacy and Toxicity Analysis of the Compassionate Use Program of Nivolumab in Patients with Advanced Squamous Cell Non-Small Cell Lung Cancer.

Oncol Res Treat 2019 Apr 17;42(5):243-254. Epub 2019 Apr 17.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.

Background: Anti-PD1 monoclonal antibody nivolumab is an approved therapy option for the treatment of advanced squamous cell non-small cell lung cancer (SQ-NSCLC) patients. Data outside clinical trials about therapy efficacy and safety in later therapy line treatments have rarely been described until now.

Methods: We performed a retrospective data analysis of patients who were enrolled into the nivolu-mab Compassionate Use Program (CUP) in Germany. Read More

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http://dx.doi.org/10.1159/000499321DOI Listing

Blood Chromogranin A is Not Effective as a Biomarker for Diagnosis or Management of Bronchopulmonary NET/NET.

Neuroendocrinology 2019 Apr 16. Epub 2019 Apr 16.

Background: Identification of circulating tumor markers for clinical management in bronchopulmonary (BP) neuroendocrine tumors/neoplasms (NET/NEN) is of considerable clinical interest. Chromogranin A (CgA), a "universal" NET biomarker, is considered controversial as a circulating biomarker of BPNEN.

Aim: Assess utility of CgA in the diagnosis and management of BPNEN in a multicentric study. Read More

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http://dx.doi.org/10.1159/000500202DOI Listing

IL1RN Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population.

Chemotherapy 2019 Apr 17:1-8. Epub 2019 Apr 17.

Department of Radiotherapy, Shaanxi Provincial Cancer Hospital Affiliated to Medical College, Xi'an Jiaotong University, Xi'an, China,

Background: Recent evidence suggested that IL1RN (interleukin-1 receptor antagonist) polymorphisms increased the susceptibility to cancers. The present study aimed to evaluate whether IL1RN was related to esophageal cancer susceptibility in a Northwest Han Chinese population.

Methods: The case-control study was conducted on 384 esophageal cancer patients and 499 healthy controls. Read More

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http://dx.doi.org/10.1159/000496400DOI Listing

Fruit and Vegetable Treatment of Chronic Kidney Disease-Related Metabolic Acidosis Reduces Cardiovascular Risk Better than Sodium Bicarbonate.

Am J Nephrol 2019 Apr 17;49(6):438-448. Epub 2019 Apr 17.

Department of Internal Medicine, Texas A&M Health Sciences Center College of Medicine, Dallas, Texas, USA,

Background: Current guidelines recommend treatment of metabolic acidosis in chronic kidney disease (CKD) with sodium-based alkali. We tested the hypothesis that treatment with base-producing fruits and vegetables (F + V) better improves cardiovascular disease (CVD) risk indicators than oral sodium bicarbonate (NaHCO3).

Methods: We randomized 108 macroalbuminuric, matched, nondiabetic CKD patients with metabolic acidosis to F + V (n = 36) in amounts to reduce dietary acid by half, oral NaHCO3 (HCO3, n = 36) 0. Read More

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http://dx.doi.org/10.1159/000500042DOI Listing

Measuring Quality of Life in the Speaker with Dysarthria: Reliability and Validity of the European Portuguese Version of the QoL-DyS.

Folia Phoniatr Logop 2019 Apr 17:1-15. Epub 2019 Apr 17.

Dipartimento di Scienze Biomediche e Cliniche "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Background: The impact of acquired dysarthria on the person's life and social participation is well recognized and is the key to the process of rehabilitation. Evaluation of the effectiveness of an intervention that addresses this impact is a challenge for clinicians and researchers.

Objectives: The purpose of this study was to evaluate the validity and reliability of the European Portuguese version of the Quality of Life in the Speaker with Dysarthria (QoL-DyS). Read More

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http://dx.doi.org/10.1159/000495564DOI Listing

The Mealtime Assessment Scale (MAS): Part 2 - Preliminary Psychometric Analysis.

Folia Phoniatr Logop 2019 Apr 17:1-12. Epub 2019 Apr 17.

Department of Biomedical and Clinical Sciences "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Aims: The Mealtime Assessment Scale (MAS) was developed to assess swallowing safety and efficacy during the meal. The study aims to perform a preliminary validation of MAS by investigating internal consistency, inter-rater agreement, concurrent and known-group validity, and responsiveness.

Methods: MAS was tested on 100 persons without dysphagia (group 1) and 100 persons with dysphagia (group 2). Read More

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http://dx.doi.org/10.1159/000494136DOI Listing

Sense of Effort and Articulatory Contact Pressure Associated with Talking by Individuals Using Tracheoesophageal Speech.

Authors:
Jeff Searl

Folia Phoniatr Logop 2019 Apr 17:1-10. Epub 2019 Apr 17.

Hearing and Speech Department, University of Kansas Medical Center, Kansas City, Kansas, USA,

Background/aims: The aims of this study were (1) to determine locations of increased effort in the body when talking using tracheoesophageal speech (TES); (2) to compare talking effort for participants using TES and those using laryngeal speech; (3) to compare tongue-palate contact pressure during talking for TES and laryngeal speech; and (4) to assess the relationship between talking effort and articulatory contact pressure (ACP).

Methods: This cohort comparison study included 16 individuals using TES and 10 using laryngeal speech. Participants rated talking effort on a visual analog scale and then rated effort in the lungs, throat, oral cavity, brain (cognitive) and arm/shoulder. Read More

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http://dx.doi.org/10.1159/000496794DOI Listing

Tunable spin-state bistability in a spin crossover molecular complex.

J Phys Condens Matter 2019 Apr 17. Epub 2019 Apr 17.

Department of Physics and Astronomy and Center for Materials Research and Analysis, University of Nebraska- Lincoln, Jorgensen Hall, 855 North 16th Str., NE 68588-0299, Lincoln, 68588-0299, UNITED STATES.

The spin crossover (SCO) transitions at both the surface and over the entire volume of the [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)] polycrystalline films on Al2O3 substrates have been studied, where pz = pyrazol-1-yl and bipy = 2,2'-bipyridine. For [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)] films of hundreds of nm thick, magnetometry and x-ray absorption spectroscopy measurements show thermal hysteresis in the SCO transition with temperature, although the transition in bulk [Fe{H2B(pz)2}2(bipy)] occurs in a non-hysteretic fashion at 157 K. While the size of the crystallites in those films are similar, the hysteresis becomes more prominent in thinner films, indicating a significant effect of the [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)]/Al<sub>2</sub>O<sub>3</sub> interface. Read More

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http://iopscience.iop.org/article/10.1088/1361-648X/ab1a7d
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http://dx.doi.org/10.1088/1361-648X/ab1a7dDOI Listing
April 2019
1 Read
2.346 Impact Factor

Localization of liver lesions in abdominal CT imaging: II. Mathematical model observer performance correlates with human observer performance for localization of liver lesions in abdominal CT imaging.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA, Rochester, Minnesota, UNITED STATES.

Purpose: Determination of the effect of protocol modifications on diagnostic performance in CT with human observers is extremely time-consuming, limiting the applicability of such methods in routine clinical practice. In this work, we sought to determine whether a channelized Hotelling observer (CHO) could predict human observer performance for the task of liver lesion localization as background, reconstruction algorithm, dose, and lesion size were varied. Materials and Methods: Liver lesions (5mm, 7mm, and 9mm) were digitally inserted into the CT projection data of patients with normal livers and water phantoms. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1a62DOI Listing

Elastic properties and intrinsic strength of two-dimensional InSe flakes.

Nanotechnology 2019 Apr 17. Epub 2019 Apr 17.

University of Washington, Seattle, Washington, UNITED STATES.

Mechanical property of two-dimensional (2D) materials is critical for their applications in functional devices as well as for strain engineering. Here, we report the Young's modulus and breaking strength of multilayered InSe, an emerging 2D semiconductors of layered group III chalcogenide. Few-layer InSe flaks were exfoliated from bulk InSe crystal onto Si/SiO2 substrate with micro-fabricated holes, and indentation tests were carried using an Atomic Force Microscopy (AFM) probe. Read More

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http://iopscience.iop.org/article/10.1088/1361-6528/ab1a96
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http://dx.doi.org/10.1088/1361-6528/ab1a96DOI Listing
April 2019
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Microwave thermal ablation using CT-scanner for predicting the variation of ablated region over time: advantages and limitations.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Technical Unit of Radiation Biology and Human Health, ENEA, Casaccia Research Centre, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rome, Rome, ITALY.

This study aims at investigating in real-time the structural and dynamical changes occurring in an ex-vivo tissue during a microwave thermal ablation (MTA) treatment. The proposed set-up was based on ex vivo liver tissue inserted in a specific box, in which 3 fibre-optic (FO) temperature probes were introduced to measure the temperature increase over time. Computed Tomography (CT) imaging technique was exploited to experimentally study in real-time the Hounsfield Units (HU) modification occurring during MTA. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1a67DOI Listing

Inhibition of MRP4 alleviates sepsis-induced acute lung injury in rats.

Int Immunopharmacol 2019 Apr 14;72:211-217. Epub 2019 Apr 14.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, China. Electronic address:

This study was undertaken to examine the regulatory role of multidrug resistance-associated protein 4 (MRP4) in an experimental model of sepsis-induced acute lung injury in rats. Sepsis was induced by cecal ligation and puncture in anesthetized rats. Animals were then randomly assigned to receive intravenous injection of vehicle or MRP4 inhibitor (MK571, 20 mg/kg). Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.009DOI Listing

Halogenated flame retardants in mangrove sediments from the Pearl River Estuary, South China: Comparison with historical data and correlation with microbial community.

Chemosphere 2019 Apr 11;227:315-322. Epub 2019 Apr 11.

State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.

Polybrominated diphenyl ethers (PBDEs), decabromodiphenyl ethane (DBDPE), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), tetrabromobisphenol A (TBBPA), hexabromocyclododecane (HBCDD) and dechlorane plus (DP) were measured in sediments collected from three mangrove wetlands of the Pearl River Estuary (PRE) in South China. This study aims to investigate the distribution of these halogenated flame retardants (HFRs) and the correlations between HFRs and microbial community structure in mangrove sediments. Concentrations of PBDEs, DBDPE, BTBPE, TBBPA, HBCDD and DP in mangrove sediments ranged from 6. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.075DOI Listing

Quantitation of vitamin K1 in serum using online SPE-LC-MS/MS and the challenges of working with vitamin K.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 7;1117:41-48. Epub 2019 Apr 7.

Department of Clinical Biochemistry and Immunology, Lillebaelt Hospital, Vejle, Denmark.

Vitamin K1 (phylloquinone) is one of the vitamin Ks. Several studies have previously investigated the role of vitamin K1 status in respect to disease, but without consistent results. Since vitamin K deficiency has been associated with different disease states it is important to develop a biochemical analysis with sufficient sensitivity and a low limit of quantitation (LOQ). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183176
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http://dx.doi.org/10.1016/j.jchromb.2019.04.010DOI Listing
April 2019
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An extensively shared antibiotic resistome among four seasons suggests management prioritization in a subtropical riverine ecosystem.

Sci Total Environ 2019 Apr 4;673:533-540. Epub 2019 Apr 4.

Aquatic EcoHealth Group, Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:

Although seasonality is a key driver of environmental fluctuation in aquatic ecosystems, there exists limited knowledge on the factors controlling the distribution of antibiotic resistance genes (ARGs) across seasons at a watershed scale. Here we used high-throughput quantitative PCR to quantify 285 ARGs conferring resistance to most major classes of antibiotics, reveal their spatial and seasonal distribution patterns, and depict the underlying mechanisms in a subtropical riverine ecosystem under low and high human pressures, in Xiamen city, southeast China. Our results showed that spatial differences in ARG richness and abundance overwhelmed their seasonal variations, with only ARGs that confer resistance to sulfonamide and vancomycin being significantly different across seasons. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.031DOI Listing

Soil organic carbon stabilization mechanisms in a subtropical mangrove and salt marsh ecosystems.

Sci Total Environ 2019 Apr 10;673:502-510. Epub 2019 Apr 10.

Collaborative Innovation Center of Sustainable Forestry in Southern China of Jiangsu Province, Nanjing Forestry University, Nanjing 210037, China.

Mangrove and salt marsh ecosystems are one of the most productive ecosystems in terrestrial ecosystems, playing an important role in global carbon (C) cycling. The anaerobic condition in coastal wetland usually impedes the decomposition of soil organic carbon (SOC). However, the intrinsic stabilization mechanisms of SOC other than environmental factors are poorly understood in coastal wetland. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.122DOI Listing

Atomic-scale insights into zeolite-based catalysis in NO decomposition.

Sci Total Environ 2019 Apr 1;673:266-271. Epub 2019 Apr 1.

State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Nitrous oxide (NO) has been the most serious ozone-depleting species throughout the 21st century. Zeolite-based catalysis is a highly promising method for NO removal in large-scale industrial applications. However, the exchanged transition metal species in zeolites greatly influence the performance of catalysts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193149
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http://dx.doi.org/10.1016/j.scitotenv.2019.03.481DOI Listing
April 2019
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Effect of fluorine substitution on sintering behaviour, mechanical and bioactivity of hydroxyapatite.

J Mech Behav Biomed Mater 2019 Apr 9;95:136-142. Epub 2019 Apr 9.

Bioceramics and Coating Division, CSIR-Central Glass & Ceramic Research Institute, 196 Raja S.C. Mullick Road, Kolkata 700032, India. Electronic address:

Fluorine substituted hydroxyapatite (FAp) with different degree of fluorine (F) substitution, has been synthesized using hydrothermal synthesis method. In the present work, as synthesized powders were consolidated by sintering at 1200 °C in air for 1 h. The sintered specimens were characterized using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) for phase analysis. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.03.032DOI Listing

Recyclable fluorescent chemodosimeters based on 8-hydroxyquinoline derivatives for highly sensitive and selective detection of mercury(II) in aqueous media and test strips.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 4;218:196-205. Epub 2019 Apr 4.

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China. Electronic address:

Four novel highly selective 8-hydroxyquinoline-based fluorescent chemodosimeters (1-4) were synthesized for the rapid analysis of Hg in aqueous solution and on paper strips, which probably attributed to the excited state intramolecular proton transfer (ESIPT) process. Chemodosimeter 1 was evaluated as a Hg-ratiometric fluorescent sensor while others (2, 3 and 4) displayed fluorescence turn-on response for Hg among the various survey metal ions. We demonstrated that chemodosimeters (1-4) could recognized Hg ions based on a 1:1 stoichiometric binding event with fast detection time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193037
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http://dx.doi.org/10.1016/j.saa.2019.04.004DOI Listing
April 2019
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Revelation of microalgae's lipid production and resistance mechanism to ultra-high Cd stress by integrated transcriptome and physiochemical analyses.

Environ Pollut 2019 Apr 8;250:186-195. Epub 2019 Apr 8.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. Electronic address:

The ultra-high Cd polluted environment is a special habitat in nature. Analysis of the biological adaptation and resistance mechanism of Auxenochlorella protothecoides UTEX234 to ultra-high Cd stress would offer some inspiring understanding on Cd detoxification mechanism and help discovering highly active bioremediation agents. In this study, integrated analyses of the transcriptome, multi-physiological and biochemical data and fatty acid profilings of UTEX2341 were performed for the first time. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.018DOI Listing

Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.

Eur J Med Chem 2019 Apr 5;173:154-166. Epub 2019 Apr 5.

Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Herestraat 49 Box 1041, B-3000, Leuven, Belgium. Electronic address:

Aminoacyl-tRNA synthetases (aaRSs) catalyse the ATP-dependent coupling of an amino acid to its cognate tRNA. Being vital for protein translation aaRSs are considered a promising target for the development of novel antimicrobial agents. 5'-O-(N-aminoacyl)-sulfamoyl adenosine (aaSA) is a non-hydrolysable analogue of the aaRS reaction intermediate that has been shown to be a potent inhibitor of this enzyme family but is prone to chemical instability and enzymatic modification. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234193030
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http://dx.doi.org/10.1016/j.ejmech.2019.04.003DOI Listing
April 2019
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Further terpenoids from Euphorbia tirucalli.

Fitoterapia 2019 Apr 14. Epub 2019 Apr 14.

BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France. Electronic address:

The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated C) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.001DOI Listing

Complications in staged late titanium cranioplasty and ventriculoperitoneal shunting for traumatic brain injury patients.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Zhongshan city people's hospital, Zhongshan, Guangdong, China.

Background: Hydrocephalus is a common complication following decompressive craniectomy (DC). Ventriculoperitoneal shunt (VPS) was required for some patients before receiving cranioplasty (CP). Presence of a VPS is regarded as a risk factor for overall CP complications. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.079DOI Listing

Seed-based connectivity analysis of resting-state fMRI in patients with brain tumors: a practical approach.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

International Neuroscience Institute, Rudolf-Pichlmayr-Straße 4, D - 30625 Hannover, Germany; Leibniz Institute, Germany.

Objective: In this study, we are presenting our experience using resting state functional magnetic resonsce imaging (rs-fMRI) in preoperative planning. We performed goup analysis to demonestrate the effects of brain tumor on resting state networks (RSNs) METHODS: Thirty patients with supratentorial gliomas were included in the study. Preoperative rs-fMRI and structural MRI were performed in all cases. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.073DOI Listing

Meta-analysis of the prognosis of Different treatments of symptomatic moyamoya disease.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China; Key Laboratory of Post-Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education in China and Tianjin, Tianjin Neurological Institute, Tianjin, 30052China. Electronic address:

Objective: The purpose of this study was to evaluate the efficacy of surgical revascularization versus conservative treatment and different surgical modalities, in order to provide evidence for the patient with MMD to choose the appropriate treatment.

Methods: We comprehensively searched PubMed, Embase, Web of Science and the Cochrane Library for the articles published regarding MMD treatment. If the I value, which evaluated the heterogeneity, was less than 50%, a fixed effect model was used; if not, a random effect model was applied. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.062DOI Listing

Preoperative and histological predictors of recurrence and survival in atypical meningioma after initial gross total resection.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery; Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, USA 10029. Electronic address:

Objective: Atypical (WHO grade II) meningiomas (AM) are associated with a substantial risk for recurrence even following a complete, gross total resection (GTR). The present study aimed to evaluate clinical and AM tumor histopathological features that may predict risk of recurrence and survival within this patient population.

Methods: 72 consecutive patients and corresponding tumor specimens who received a primary GTR for an AM from 2007-2016 at a single institution were reviewed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.069DOI Listing

Association of admission serum glucose-phosphate ratio with severity and prognosis of aneurysmal subarachnoid hemorrhage.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing, 210008 Jiangsu Province PR China. Electronic address:

Background: and Purpose Serum hyperglycemia and hypophosphatemia were reported to be common in patients with aneurysmal subarachnoid hemorrhage (aSAH). This study was aimed to explore whether admission serum glucose-phosphate ratio was associated with the severity and prognosis of aSAH.

Methods: We retrospectively analyzed 198 patients with aSAH who were admitted within 24 hours of hemorrhage occurrence to a single academic hospital from June 2016 to September 2017. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.071DOI Listing

Spotted knifejaw (Oplegnathus punctatus) MyD88: Intracellular localization, signal transduction function and immune responses to bacterial infection.

Fish Shellfish Immunol 2019 Apr 14. Epub 2019 Apr 14.

Key Laboratory of Marine Genetics and Breeding, Ministry of Education, College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong, China. Electronic address:

Myeloid differentiation factor 88 (MyD88) links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of NF-κB as a "bridge" molecular in response to exogenous pathogen, but the function in spotted knifejaw (Oplegnathus. punctatus), a commercial fish in China, is still unknown. We present a functional analysis of spotted knifejaw MyD88 (OppMyD88) with a typical death domain (DD) at the N-terminus and a conservative Toll/IL-1R (TIR) domain at the C-terminus and suggest that MyD88 is important for the activation of TLR-mediated NF-κB with the synergy between domains. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.035DOI Listing

CREPT promotes glioma cell proliferation and invasion by activating Wnt/β-catenin pathway and is a novel target of microRNA-596.

Biochimie 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi Province, China. Electronic address:

Cell cycle-related and expression elevated protein in tumor (CREPT) is emerging as a novel cancer-related gene that is dysregulated in many kinds of malignancies. However, the expression and biological role of CREPT in glioma remains unclear. In the present study, we aimed to explore the potential function and regulation mechanism of CREPT in glioma. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.04.014DOI Listing

Clinical, immunologic, and molecular spectrum of patients with LPS-responsive beige-like anchor protein (LRBA) deficiency: a systematic review.

J Allergy Clin Immunol Pract 2019 Apr 14. Epub 2019 Apr 14.

Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:

Background: LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency and immune dysregulation syndrome caused by biallelic mutations in the LRBA gene. These mutations usually abrogate the protein expression of LRBA, leading to a broad spectrum of clinical phenotypes including autoimmunity, chronic diarrhea, hypogammaglobulinemia and recurrent infections.

Objective: Our aim was to systematically collect all studies reporting on the clinical manifestations, molecular and laboratory findings, and management of patients with LRBA deficiency. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.011DOI Listing

Rates, Predictors and Mortality of Community-Onset Bloodstream Infections due to Pseudomonas aeruginosa: Systematic Review and Meta-Analysis.

Clin Microbiol Infect 2019 Apr 14. Epub 2019 Apr 14.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena / Departamento de Medicina, Universidad de Sevilla / Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain.

Background: Pseudomonas aeruginosa is mostly a nosocomial pathogen affecting predisposed patients. However, community-onset bloodstream infections (CO-BSI) caused by this organism are not exceptional.

Objectives: To assess the predisposing factors for CO-BSI due to P. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.04.005DOI Listing

'Acute Flare-Ups' In Patients With, Or At High Risk Of, Knee Osteoarthritis: A Daily Diary Study With Case-Crossover Analysis.

Osteoarthritis Cartilage 2019 Apr 14. Epub 2019 Apr 14.

Clinical Epidemiology, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, UK. Electronic address:

Objective: To determine the natural history of flare-ups in knee osteoarthritis and their relation to physical exposures.

Design: Adults aged ≥45 years with a recent primary care consultation for knee OA/arthralgia completed a daily pen-and-paper diary for up to 3 months, including questions on average knee pain intensity, pain descriptors, other symptoms, activity interference, and selected physical exposures (prolonged kneeling, squatting, climbing stairs, ladders, and moving/lifting heavy objects). Informed by a systematic review, flare-ups were defined a priori. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.003DOI Listing

Simulation In Surgical Training: Prospective Cohort Study Of Access, Attitudes And Experiences Of Surgical Trainees In The Uk And Ireland.

Int J Surg 2019 Apr 14. Epub 2019 Apr 14.

Association of Surgeons in Training, 35-43 Lincoln's Inn Fields, London, WC2A 3PE.

Background: Surgical training is evolving, and simulation is becoming more important as a way to expedite the early learning curve and augment surgical techniques. With novel technology, and innovation, major changes are possible in how surgeons are trained. The integration of these concepts into the surgical curriculum may drive up educational standards and enhance patient safety. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.04.004DOI Listing

Anti-diabetic activity of PUFAs-rich extracts of Chlorella pyrenoidosa and Spirulina platensis in rats.

Food Chem Toxicol 2019 Apr 14. Epub 2019 Apr 14.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau SAR, China. Electronic address:

The contributions to hypoglycemic function and gut microbiota regulation by water and ethanol extracts of the microalgae Chlorella pyrenoidosa and Spirulina platensis were determined. An ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry analysis indicated that most of the compounds in the 55% ethanol extracts of C. pyrenoidosa (CP55) and S. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.017DOI Listing

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

Cell Rep 2019 Apr;27(3):971-986.e9

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada; Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

Glioblastoma therapies have remained elusive due to limitations in understanding mechanisms of growth and survival of the tumorigenic population. Using CRISPR-Cas9 approaches in patient-derived GBM stem cells (GSCs) to interrogate function of the coding genome, we identify actionable pathways responsible for growth, which reveal the gene-essential circuitry of GBM stemness and proliferation. In particular, we characterize members of the SOX transcription factor family, SOCS3, USP8, and DOT1L, and protein ufmylation as important for GSC growth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193036
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http://dx.doi.org/10.1016/j.celrep.2019.03.047DOI Listing
April 2019
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A Comprehensive Drosophila melanogaster Transcription Factor Interactome.

Cell Rep 2019 Apr;27(3):955-970.e7

Department of Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Systems Biology Graduate Program, Harvard University, Cambridge, MA 02138, USA; Bioinformatics and Integrative Genomics Ph.D. Program, Harvard University, Cambridge, MA 02138, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Combinatorial interactions among transcription factors (TFs) play essential roles in generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid (Y2H) assays on nearly all sequence-specific Drosophila TFs, we identified 1,983 protein-protein interactions (PPIs), more than doubling the number of currently known PPIs among Drosophila TFs. For quality assessment, we validated a subset of our interactions using MITOMI and bimolecular fluorescence complementation assays. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.071DOI Listing

Parallel Processing of Sound Dynamics across Mouse Auditory Cortex via Spatially Patterned Thalamic Inputs and Distinct Areal Intracortical Circuits.

Cell Rep 2019 Apr;27(3):872-885.e7

Department of Biology, University of Maryland, College Park, MD 20742, USA; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD 20742, USA. Electronic address:

Natural sounds have rich spectrotemporal dynamics. Spectral information is spatially represented in the auditory cortex (ACX) via large-scale maps. However, the representation of temporal information, e. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.069DOI Listing

Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK.

Cell Rep 2019 Apr;27(3):847-859.e6

Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain. Electronic address:

Alternative splicing is a prevalent mechanism of gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps of mRNA biogenesis. Here, we show that osmostress has an impact on the regulation of alternative splicing (AS), which is partly mediated through the action of p38 SAPK. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.060DOI Listing

Exploring the fatigue affecting electroencephalography based functional brain networks during real driving in young males.

Neuropsychologia 2019 Apr 14. Epub 2019 Apr 14.

Department of Mechanical Engineering and Automation, Northeastern University, 110819 Shenyang, Liaoning, China.

In recent years, a large proportion of traffic accidents are caused by driver fatigue. The brain has been conceived as a complex network, whose function can be assessed with EEG. Hence, in this research, fourteen subjects participated in the real driving experiments, and a comprehensive EEG-based expert system was designed for detecting driver fatigue. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.04.004DOI Listing

Can Predicted Protein 3D-Structures Provide Reliable Insights into whether Missense Variants Are Disease-Associated?

J Mol Biol 2019 Apr 14. Epub 2019 Apr 14.

Structural Bioinformatics Group, Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Sir Ernst Chain Building, Imperial College London, London SW7 2AZ, UK. Electronic address:

Knowledge of protein structure can be used to predict the phenotypic consequence of a missense variant. Since structural coverage of the human proteome can be roughly tripled to over 50% of the residues if homology-predicted structures are included in addition to experimentally-determined coordinates, it is important to assess the reliability of using predicted models when analysing missense variants. Accordingly, we assess whether a missense variant is structurally damaging by using experimental and predicted structures. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.04.009DOI Listing
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