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Beyond the fear: Nurses' experiences caring for patients with Middle East respiratory syndrome: a phenomenological study.

J Clin Nurs 2020 Jun 4. Epub 2020 Jun 4.

College of Nursing, Gachon University, Incheon, South Korea.

Aim And Objectives: We explored the experiences of Korean nurses who had directly cared for patients with Middle East respiratory syndrome (MERS) to derive the structure and meaning of these experiences.

Background: In 2015, the MERS epidemic struck Korea, and ill-prepared nurses had to care for patients with MERS. Nurses experienced conflict between their fear of the disease and their work and professional ethic. Read More

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http://dx.doi.org/10.1111/jocn.15366DOI Listing

Subspecies differentiation in an enigmatic chaparral shrub species.

Am J Bot 2020 Jun 4. Epub 2020 Jun 4.

University of California, Riverside, Riverside, CA, 92521.

Premise: Delimiting biodiversity units is difficult in organisms in which differentiation is obscured by hybridization, plasticity, and other factors that blur phenotypic boundaries. Such work is more complicated when the focal units are subspecies, the definition of which has not been broadly explored in the era of modern genetic methods. Eastwood manzanita (Arctostaphylos glandulosa Eastw. Read More

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http://dx.doi.org/10.1002/ajb2.1496DOI Listing

Accelerated brain aging in sepsis survivors with cognitive long-term impairment.

Eur J Neurosci 2020 Jun 4. Epub 2020 Jun 4.

Moritz Klinik Bad Klosterlausnitz, Hermann-Sachse-Strasse 46, 07639, Bad Klosterlausnitz, Germany.

In the last years, cognitive impairment was emphasized to be a prominent long-term sequela of sepsis. The level of cognitive impairment is comparable with that in mild cognitive impairment (MCI) patients. Whether sepsis survivors also show a comparable brain atrophy is still unclear. Read More

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http://dx.doi.org/10.1111/ejn.14850DOI Listing

UGT1A3 and sex are major determinants of telmisartan pharmacokinetics - a comprehensive pharmacogenomic study.

Clin Pharmacol Ther 2020 Jun 4. Epub 2020 Jun 4.

Department of Clinical Pharmacology, University of Helsinki, HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland.

To investigate how variability in multiple pharmacokinetic genes associates with telmisartan exposure, we determined telmisartan single-dose (40 mg) pharmacokinetics and sequenced 379 genes in 188 healthy volunteers. Intronic UGT1A variants showed the strongest associations with the area under the plasma concentration-time curve (AUC ) and peak plasma concentration (C ) of telmisartan. These variants were strongly linked with the increased function UGT1A3*2 allele, suggesting that it is the causative allele underlying these associations. Read More

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http://dx.doi.org/10.1002/cpt.1928DOI Listing

Partnership between Nurse Navigators and adult persons living with complex chronic disease - an exploratory study.

J Clin Nurs 2020 Jun 4. Epub 2020 Jun 4.

School of Nursing & Midwifery &, Menzies Health Institute, Griffith University.

Aims: The aim of this study was to explore Nurse Navigators and consumers' experience of partnership.

Background: The Nurse Navigator has recently emerged as an advanced practice role in the care of persons with complex and chronic disease states. Self-care is an important principle in chronic disease models of care, requiring health care practitioners to partner with clients in their care. Read More

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http://dx.doi.org/10.1111/jocn.15364DOI Listing

[Comprehensive Preoperative Evaluation of Patients with Lung Cancer].

Zentralbl Chir 2020 Jun 4;145(3):293-302. Epub 2020 Jun 4.

Klinik für Thoraxchirurgie, Thoraxzentrum Ruhrgebiet, Herne und Bochum.

Surgical resection continues to be a mainstay of curative treatment of patients with non-small cell lung cancers stages I - III and some small cell lung cancers. Reported rates of complications and mortality vary considerably. Therefore, a thorough and comprehensive preoperative evaluation of lung cancer patients is crucial in order to select appropriate surgical candidates and to determine their individual risk, including the extent of resection possible. Read More

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http://dx.doi.org/10.1055/a-1027-1320DOI Listing

Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis and grading of pancreatic neuroendocrine tumors: a retrospective analysis of 110 cases.

Endoscopy 2020 Jun 4. Epub 2020 Jun 4.

General and Pancreatic Surgery Unit, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.

Background:  Data on the reliability of the Ki-67 index and grading calculations from endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of pancreatic neuroendocrine tumors (PanNETs) are controversial. We aimed to assess the accuracy of these data compared with histology.

Methods:  Cytological analysis from EUS-FNA in patients with suspected PanNETs (n = 110) were compared with resection samples at a single institution. Read More

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http://dx.doi.org/10.1055/a-1180-8614DOI Listing

Discharging Medically Complex Infants with Supplemental Nasogastric Tube Feeds: Impact on Neonatal Intensive Care Unit Length of Stay and Prevention of Gastrostomy Tubes.

Am J Perinatol 2020 Jun 4. Epub 2020 Jun 4.

Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky.

Objective:  The aim of this study is to evaluate the feasibility, safety, and efficacy of discharge with supplemental nasogastric tube (NGT) feeds in medically complex infants.

Study Design:  Cohort study of 400 infants enrolled in the Transitional Medical Home (TMH) program at Duke University Level IV neonatal intensive care unit from January 2013 to 2017.

Results:  Among 400 infants enrolled in the TMH, 57 infants were discharged with an NGT. Read More

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http://dx.doi.org/10.1055/s-0040-1709497DOI Listing

Hypothyroxinemia Detected at 4 Weeks of Life in Preterm Infants Born at Less than 30 Weeks of Gestation.

Am J Perinatol 2020 Jun 4. Epub 2020 Jun 4.

Department of Pediatrics, University of Iowa, Iowa City, Iowa.

Objective:  Data on free thyroxine (FT4) concentrations beyond first 2 weeks of preterm infants are limited. This study was aimed to describe the association between perinatal characteristics and FT4 concentrations and the incidence of hypothyroxinemia at 4 weeks.

Study Design:  Retrospective analysis of serum thyroid function tests at 4 weeks in preterm infants <30 weeks of gestation. Read More

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http://dx.doi.org/10.1055/s-0040-1712168DOI Listing

Polymorphisms of IRAK1 gene on X chromosome is associated with Hashimoto's thyroiditis in Korean Children.

Endocrinology 2020 Jun 4. Epub 2020 Jun 4.

Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Auto immune thyroid disease (AITD) is predominant in female and has been focused on the sexual diploid in immune response. The interleukin 1 receptor associated kinase 1 (IRAK1) gene on the X chromosome was recently suggested as strong autoimmune disease-susceptible loci, second to the major histocompatibility complex region. We investigated the frequency of IRAK1 single-nucleotide polymorphisms (SNPs) in children with autoimmune thyroid disease (AITD). Read More

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http://dx.doi.org/10.1210/endocr/bqaa088DOI Listing

Dementia is associated with poorer quality of care and outcomes after stroke: An Observational Study.

J Gerontol A Biol Sci Med Sci 2020 Jun 4. Epub 2020 Jun 4.

Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia.

Background: To determine if pre-existing dementia is associated with poorer quality of care and outcomes after stroke in the acute hospital phase.

Methods: This was a retrospective analysis of pooled data from the Australian Stroke Foundation national audit conducted in 2015 and 2017. Dementia status was obtained from the medical records. Read More

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http://dx.doi.org/10.1093/gerona/glaa139DOI Listing

Association of hypertension and antihypertensive treatment with COVID-19 mortality: a retrospective observational study.

Eur Heart J 2020 Jun 4. Epub 2020 Jun 4.

Department of Cardiology, Xijing Hospital, Changle West Road, Xi'an, 710032, China.

Aims: It remains unknown whether the treatment of hypertension influences the mortality of patients diagnosed with coronavirus disease 2019 (COVID-19).

Methods And Results: This is a retrospective observational study of all patients admitted with COVID-19 to Huo Shen Shan Hospital. The hospital was dedicated solely to the treatment of COVID-19 in Wuhan, China. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa433DOI Listing

Development of cellulose-based conductive fabrics with electrical conductivity and flexibility.

PLoS One 2020 4;15(6):e0233952. Epub 2020 Jun 4.

Department of Clothing and Textiles, Sookmyung Women's University, Seoul, South Korea.

This study aimed to produce cellulose-based conductive fabrics with electrical conductivity and flexibility. Bacterial cellulose (BC) and three chemical cellulose (CC), namely methyl cellulose (MC), hydroxypropyl cellulose (HPMC) and carboxymethyl cellulose (CMC) were in situ polymerized with aniline and the four conductive cellulose fabrics were compared and evaluated. Matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy analysis confirmed that three CC-PANI composites displayed longer and more stable polymerization pattern than BC-PANI because of the different polymerization method: bulk polymerization for BC-PANI and emulsion polymerization for CC-PANI, respectively. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233952PLOS

Evaluation of bleb characteristics after trabeculectomy and glaucoma implant surgery in rabbit.

Ophthalmic Res 2020 Jun 4. Epub 2020 Jun 4.

The characteristics of the conjunctival bleb are some of the most important factors for the surgical success of glaucoma filtering surgery. To improve surgical outcome, we investigated histology of bleb after three glaucoma surgeries. Surgery was performed in the 21 white rabbits. Read More

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http://dx.doi.org/10.1159/000509135DOI Listing

A recognition method for extreme bradycardia by arterial blood pressure signal modeling with curve fitting.

Physiol Meas 2020 Jun 4. Epub 2020 Jun 4.

Changshu Institute of Technology, Changshu, Jiangsu, CHINA.

Objective: The aim of this study is to investigate the potential of arterial blood pressure (ABP) signal for the detection of the subjects with life-threatening extreme bradycardia (EBr).

Approach: The steps of the proposed method include ABP signal preprocessing, ABP wave segmentation, model parameters estimation, and EBr subject detection. Firstly, the noise, interference, and abnormal segments are eliminated in pre-processing. Read More

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http://dx.doi.org/10.1088/1361-6579/ab998dDOI Listing

Low-temperature synthesis and electrocatalytic application of large-area PtTe2 thin films.

Nanotechnology 2020 Jun 4. Epub 2020 Jun 4.

AMBER and School of Chemistry, University of Dublin Trinity College, Dublin, 2, IRELAND.

The synthesis of transition metal dichalcogenides (TMDs) has been a primary focus for 2D nanomaterial research over the last 10 years, however, only a small fraction of this research has been concentrated on transition metal ditellurides. In particular, nanoscale platinum ditelluride (PtTe2) has rarely been investigated, despite its potential applications in catalysis, photonics and spintronics. Of the reports published, the majority examine mechanically-exfoliated flakes from chemical vapor transport (CVT) grown crystals. Read More

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http://dx.doi.org/10.1088/1361-6528/ab9973DOI Listing

Nanocomposite of Ag NPs and Catalytic Fluorescent Cdots for Synergistic Bactericidal Activity through Enhanced ROS Generation.

Nanotechnology 2020 Jun 4. Epub 2020 Jun 4.

Applied Sciences, IIIT Allahabad, Allahabad, 211012, INDIA.

Synthesis of catalytic fluorescent carbon dots (Cdots) by using microwave irradiation is proposed considering biodegradable starch as precursor. The as-synthesized Cdots was characterized by using fluorescence spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) analysis. It was showing high catalytic activity in photo-reduction method for formation of Silver nanoparticles (Ag NPs) without adding any additional surface passivating agents. Read More

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http://dx.doi.org/10.1088/1361-6528/ab996fDOI Listing

Pulse rate variability in cardiovascular health: a review on its applications and relationship with heart rate variability.

Physiol Meas 2020 Jun 4. Epub 2020 Jun 4.

School of Mathematics Computer Science and Engineering, City University London, Northampton Square, London EC1V 0HB, UK, London, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Heart rate variability has been largely used for the assessment of cardiac autonomic activity, due to the direct relationship between cardiac rhythm and the activity of the sympathetic and parasympathetic nervous system. In recent years, another technique, pulse rate variability , has been used for assessing heart rate variability information from pulse wave signals, especially from photoplethysmography, a non-invasive, non-intrusive, optical technique that measures the blood volume in tissue. The relationship, however, between pulse rate variability and heart rate variability is not entirely understood, and the effects of cardiovascular changes in pulse rate variability have not been thoroughly dilucidated. Read More

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http://dx.doi.org/10.1088/1361-6579/ab998cDOI Listing

Noncoplanar ferrimagnetism and local crystalline-electric-field anisotropy in the quasicrystal approximant Au70Si17Tb13.

J Phys Condens Matter 2020 Jun 4. Epub 2020 Jun 4.

Dept. Materials Science & Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, Tokyo, Tokyo, 125-8585, JAPAN.

Neutron scattering experiments have been performed to elucidate magnetic properties of the qua- sicrystal approximant Au70Si17Tb13, consisting of icosahedral spin clusters in a body-centered-cubic lattice. Bulk magnetic measurements performed on the single crystalline sample unambiguously confirm long-range ordering at TC = 11.6 ± 1 K. Read More

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http://dx.doi.org/10.1088/1361-648X/ab997dDOI Listing

"Not Everybody's an Athlete, But They Certainly Can Move": Facilitators of Physical Activity Maintenance in Older Adults in a Northern and Rural Setting.

J Aging Phys Act 2020 Jun 4:1-10. Epub 2020 Jun 4.

Although the benefits of maintaining a physical activity regime for older adults are well known, it is unclear how programs and facilities can best support long-term participation. The purpose of this study is to determine the facilitating factors of physical activity maintenance in older adults at individual, program, and community levels. Nine semistructured interviews were conducted with individuals aged 60 years and older and long-term participants (>6 months) in community-based group exercise at a clinical wellness facility in northern British Columbia, Canada. Read More

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http://dx.doi.org/10.1123/japa.2019-0393DOI Listing

A Comparison of Cardiopulmonary Exercise Testing and Field Walking Tests in Community-Dwelling Older Adults With Mild-to-Moderate Alzheimer's Dementia.

J Aging Phys Act 2020 Jun 4. Epub 2020 Jun 4.

The purpose of this study was to investigate the relationships among peak exercise parameters on 6-min walk test, shuttle walk test, and laboratory-based cardiopulmonary exercise testing in persons with Alzheimer's dementia. This study is a cross-sectional analysis of the baseline data of 90 participants (age 77.1 [6. Read More

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http://dx.doi.org/10.1123/japa.2019-0387DOI Listing

Is Stretching Exercise An Adequate Control Group in Clinical Trials Aimed at Improving Physical Fitness and Function of Older Adults? A Systematic Review and Meta-Analysis.

J Aging Phys Act 2020 Jun 4:1-22. Epub 2020 Jun 4.

This study aimed to determine if stretching exercise can be implemented as an adequate control therapy in exercise randomized controlled trials aimed at improving physical fitness and physical function in older adults. Five electronic databases were systematically searched for randomized controlled trials focused in the physical fitness and function of older adults using stretching exercise as control group. The methodological quality was assessed and a meta-analysis was carried out. Read More

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http://dx.doi.org/10.1123/japa.2019-0257DOI Listing

Comparative analysis of lentiviral gene transfer approaches designed to promote fetal hemoglobin production for the treatment of β-hemoglobinopathies.

Blood Cells Mol Dis 2020 May 29;84:102456. Epub 2020 May 29.

University Children's Clinic Department of Pediatrics I, Hematology and Oncology, University of Tübingen, Germany. Electronic address:

β-Hemoglobinopathies are among the most common single-gene disorders and are caused by different mutations in the β-globin gene. Recent curative therapeutic approaches for these disorders utilize lentiviral vectors (LVs) to introduce a functional copy of the β-globin gene into the patient's hematopoietic stem cells. Alternatively, fetal hemoglobin (HbF) can reduce or even prevent the symptoms of disease when expressed in adults. Read More

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http://dx.doi.org/10.1016/j.bcmd.2020.102456DOI Listing

Adaptation and Validation of the Health Belief Model Scale for Breast Self-Examination in Mexican Women.

Value Health Reg Issues 2020 May 31;23:30-36. Epub 2020 May 31.

Psychology School, Center for Research and Development in Health Sciences, Autonomous University of Nuevo Leon, Monterrey, Mexico.

Objectives: In Mexico, breast cancer is often not detected until it is already at an advanced stage. Many women know about breast self-examination (BSE), but few do it correctly. BSE can assist in the early detection of breast cancer, and a valid and reliable instrument to help determine the factors of the Health Belief Model that affect the practice of BSE in Mexican women would thus be advantageous. Read More

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http://dx.doi.org/10.1016/j.vhri.2019.11.006DOI Listing

Wastewater-based epidemiology combined with local prescription analysis as a tool for temporalmonitoring of drugs trends - A UK perspective.

Sci Total Environ 2020 May 15;735:139433. Epub 2020 May 15.

Department of Chemistry, Faculty of Science, University of Bath, Bath BA2 7AY, United Kingdom. Electronic address:

This paper reports the application of wastewater-based epidemiology (WBE) for the monitoring of one city in the UK in years 2014-2018 as a means of 1) exploring relative temporal changes of illicit drug usage trends across 5 sampling weeks in 5 years, (2) assessing policy impact in reducing drug consumption, focussing particularly on mephedrone, which was classified as a class B drug in the UK in 2010, and the effects of subsequent regulation such as the novel psychoactive substances (NPS) bill of 2016, (3) investigating temporal changes in consumption of prescription pharmaceuticals vs illicit drug usage, and (4) comparing consumption of prescription drugs with WBE to enable more accurate verification of prescription drugs with abuse potential. Mephedrone was quantified only for the first two years of the study, 2014-2015, and remained undetected for the next three years of the study. This shows that given enough time changes in drug policy can have an effect on drug consumption. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139433DOI Listing

The acute effects of short term exposure to particulate matter from natural and anthropogenic sources on inflammation and coagulation markers in healthy young adults.

Sci Total Environ 2020 May 15;735:139417. Epub 2020 May 15.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Solid Waste Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Airborne particulate matter is associated with increasing the risk of cardiovascular diseases. The purpose of this study was to investigate the association between air pollution conditions and MDA, vWF, and fibrinogen markers in the blood of two panels of healthy young individuals in an urban area in Tehran city with a high air pollution background and another group was living in a rural area (Ahmad Abad Mostofi), with a low air pollution background. In each group, 4 blood samples were taken as follows: one in inversion days, the second in winter, but during the existence of normal condition in terms of air pollution, the third sample in the spring during the normal condition in terms of air pollution and the fourth sample during the dust storm conditions. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139417DOI Listing

Enhancement of alkaline-oxidative delignification of wheat straw by semi-batch operation in a stirred tank reactor.

Bioresour Technol 2020 May 26;312:123589. Epub 2020 May 26.

Universidad de Guanajuato, Departamento de Ingeniería Química, Laboratorio de Análisis de Bio-Procesos Industriales, Noria Alta s/n, Guanajuato 36050, Mexico. Electronic address:

This paper compares a semi-batch operation and a conventional one of an alkaline oxidative pretreatment of wheat straw carried out in a stirred tank reactor. For the pretreatment, different concentrations of biomass (6% up to 12% w/v) and two different particle sizes (mesh #40-60 and #>60) were experimented. The performance of processes was evaluated through the analysis of lignocellulosic composition of the biomass, and the enzymatic hydrolysis of pretreated biomass using the Cellic® CTec2 enzyme complex by Novozymes®. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123589DOI Listing

Chloride salinity in a chloride-sensitive plant: Focusing on photosynthesis, hormone synthesis and transduction in tobacco.

Plant Physiol Biochem 2020 May 22;153:119-130. Epub 2020 May 22.

College of Tobacco Science, Henan Agricultural University, Zhengzhou, 450002, China. Electronic address:

Chloride (Cl) is a micronutrient and a beneficial ion for plant growth, but excess Cl easily leads to Cl salinity. As a species sensitive to Cl, tobacco experiences serious damage when encountering excessive Cl. However, the molecular mechanism by which excess Cl delays plant growth and development remain largely unknown. Read More

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http://dx.doi.org/10.1016/j.plaphy.2020.05.021DOI Listing

Efficacy of nanoparticle encapsulation on suppressing oxidation and enhancing antifungal activity of cyclic lipopeptides produced by Bacillus subtilis.

Colloids Surf B Biointerfaces 2020 Jun 1;193:111143. Epub 2020 Jun 1.

Department of Food Science and Engineering, College of Biological Sciences and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Beijing Forestry University, Beijing, 100083, China. Electronic address:

This study examined the storage instability of cyclic lipopeptides (CLs) extracted from Bacillus subtilis culture; CLs were easily oxidized and therefore quickly lost antifungal activity during storage. Solid lipid nanoparticle (SLN) encapsulation effectively suppressed the oxidation and prolonged and enhanced the antifungal efficacy of CLs through controlled release. Thermal gravimetric analysis, X-ray diffraction, and Fourier transform infrared spectroscopy revealed that hydrophobic interactions between the fatty acid moieties of CLs and SLNs fortified the crystal structure of the CL-SLN complex, thereby improving the storage stability of the encapsulated CLs. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111143DOI Listing

Enhanced bioactivity and osteogenic property of carbon fiber reinforced polyetheretherketone composites modified with amino groups.

Colloids Surf B Biointerfaces 2020 May 7;193:111098. Epub 2020 May 7.

Engineering Research Center of High Performance Plastic, Ministry of Education, College of Chemistry, Jilin University, Changchun, 130012, China. Electronic address:

Polyetheretherketone (PEEK) is considered as a potential dental and orthopedic implant material owing to its favorable thermal and chemical stability, biocompatibility and mechanical properties. However, the inherent bio-inert and inferior osseointegration of PEEK have hampered its clinical application. In addition, carbon fiber is widely used as a filler to reinforce polymers for sturdy composites owing to its high strength, modulus, etc. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111098DOI Listing

Lifting the fog of confusion about breast cancer screening guidelines: Surprise - it's about the money!

Authors:
Daniel B Kopans

Clin Imaging 2020 Apr 17;67:5-6. Epub 2020 Apr 17.

20 Manitoba Road, Waban, MA 02468, United States of America. Electronic address:

Large amounts of misinformation denigrating the benefits of breast cancer screening have been published over the past 50 years and continue to be published. Each effort to reduce breast cancer screening has been refuted, scientifically, but the efforts continue. The motivation has been unclear until the recent guidelines issued by the American Society of Breast Surgeons who support annual screening starting at the age of 40 contrasted with the American College of Physicians who advocated delaying screening until the age of 50 and then biennially. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.03.009DOI Listing

Discrimination of automotive window tint using ATR-FTIR spectroscopy and chemometrics.

Forensic Sci Int 2020 May 16;313:110338. Epub 2020 May 16.

School of Molecular and Life Sciences, Curtin University, GPO Box U1987, Perth, WA 6845, Australia; Curtin Institute of Functional Molecules and Interfaces, Curtin University, GPO Box U1987, Perth, WA 6845, Australia. Electronic address:

Automotive window tints are commonly applied to motor vehicles to reduce transmittance of light and heat into the interior. They may hence be encountered as physical evidence in criminal investigations, or in civil matters where a tint is suspected to originate from a different source than advertised. Establishing a tint's provenance would be highly relevant in such cases. Read More

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http://dx.doi.org/10.1016/j.forsciint.2020.110338DOI Listing

Autoerotic Deaths in Hamburg, Germany: Autoerotic accident or death from internal cause in an autoerotic setting? A retrospective study from 2004-2018.

Forensic Sci Int 2020 May 16;313:110340. Epub 2020 May 16.

Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Butenfeld, 34, 22529, Hamburg, Germany.

Introduction: Autoerotic deaths are rare events. The death scene is often bizarre and the death unexpected, thus often requiring forensic autopsies. Our analysis will provide an overview of the expected range of causes and manners of death in cases of autoerotic deaths. Read More

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http://dx.doi.org/10.1016/j.forsciint.2020.110340DOI Listing

Duration of labor among women with hypertensive disorders of pregnancy; A Swedish register cohort study.

Eur J Obstet Gynecol Reprod Biol 2020 May 20;251:114-118. Epub 2020 May 20.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Center for Clinical Research, Uppsala University, Falun, Sweden.

Objective: Preeclampsia is a severe obstetric complication affecting 2-8% of pregnancies. There is a common belief that women with preeclampsia experience a shorter duration of labor, where it is thought that increased inflammation that occurs with the disease facilitates labor. However, little evidence exists to support or refute this. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.024DOI Listing

PALB2 as a potential prognostic biomarker for colorectal cancer.

Comput Biol Chem 2020 May 20;87:107289. Epub 2020 May 20.

Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, No. 1158 East Park Road, Qingpu District, Shanghai 200032, PR China; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 201700, PR China. Electronic address:

Partner and localizer of BRCA2 (PALB2) is regarded as a colorectal cancer (CRC) risk gene, but the prognostic implication of PALB2 in CRC remains unclear. In this study, we evaluate the prognostic value of the gene copy number alteration (CNA) and mRNA expression of PALB2 in The Cancer Genome Atlas (TCGA) database, and then validated with our database. We downloaded the copy number and mRNA data of PALB2 from TCGA database and examined the relationship among the genetic alterations, expression levels and survival outcomes. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2020.107289DOI Listing

Gait features for discriminating between mobility-limiting musculoskeletal disorders: Lumbar spinal stenosis and knee osteoarthritis.

Gait Posture 2020 May 19;80:96-100. Epub 2020 May 19.

Division of Physical Medicine and Rehabilitation, Stanford University, Stanford, CA, United States.

Background: Functional ambulation limitations are features of lumbar spinal stenosis (LSS) and knee osteoarthritis (OA). With numerous validated walking assessment protocols and a vast number of spatiotemporal gait parameters available from sensor-based assessment, there is a critical need for selection of appropriate test protocols and variables for research and clinical applications.

Research Question: In patients with knee OA and LSS, what are the best sensor-derived gait parameters and the most suitable clinical walking test to discriminate between these patient populations and controls?

Methods: We collected foot-mounted inertial measurement unit (IMU) data during three walking tests (fast-paced walk test-FPWT, 6-min walk test- 6MWT, self-paced walk test - SPWT) for subjects with LSS, knee OA and matched controls (N = 10 for each group). Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.019DOI Listing

N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies.

Eur J Med Chem 2020 May 5;199:112279. Epub 2020 May 5.

Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

USP7 as a deubiquitinase plays important roles in regulating the stability of some oncoproteins including MDM2 and DNMT1, and thus represents a potential anticancer target. Through comparative analysis of USP7 co-crystal structures in complex with the reported piperidinol inhibitors, we noticed that the USP7 Phe409 sub-site might have good adaptability to the ligands. Based on this observation, 55 N-aromatic and N-benzyl piperidinol derivatives were designed, synthesized and biologically evaluated, among which compound L55 was identified as a highly selective and potent USP7 inhibitor (IC = 40. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112279DOI Listing

Systemic therapy in metastatic renal cell carcinoma: Emerging challenges in therapeutic choice.

Crit Rev Oncol Hematol 2020 Jun 1;152:102971. Epub 2020 Jun 1.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada; Canadian Centre for Applied Research in Cancer Control, Toronto, Ontario, Canada. Electronic address:

The treatment landscape for metastatic renal cell carcinoma (mRCC) has undergone a substantial evolution in the past decade, with a dramatic increase in the number of available systemic therapies. Although this offers promise for improved patient outcomes, this rapid pace in development has led to new challenges in therapeutic choice. For instance, the absence of direct comparative evidence across all therapeutic options has led to a critical gap in evidence to clearly define preferred systemic therapy choice. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102971DOI Listing

Historical trends of admitted patients by selected substances and their significant patient's level factors.

Addict Behav 2020 May 19;109:106478. Epub 2020 May 19.

School of Mathematical Sciences, University of Nottingham, Nottingham, UK; Department of Statistics, Comilla University, Comilla, Bangladesh.

The purposes of the study include (i) demonstrating the US national level historical trends of the number of admitted patients due to substance abuse and those reported the selected substances at the time of admission, and more importantly, (ii) identifying the significant covariates in the association of using each of the substances along with the dynamics of likelihood over the different levels of the covariates. The trend of total admitted patients shows an increasing pattern from 1992 to 2008 and later exhibits a decreasing pattern before experiencing a significant upturn again in the last two consecutive years. During the study period, the highest growth rate of around 1088% is evident for methamphetamine followed by heroin (192%) and marijuana or hashish (45%), while both cocaine or crack (-33%) and alcohol (-29%) show negative growth rates. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106478DOI Listing

Metacognitions about problematic Smartphone use: Development of a self-report measure.

Addict Behav 2020 May 22;109:106484. Epub 2020 May 22.

Department of Health Sciences, Psychology and Psychiatry Unit, University of Florence, via di San Salvi 12, Florence, Italy.

Background And Aims: Recent research has suggested that metacognitions may play a role across the spectrum of addictive behaviours, including problematic use of technological devices. Metacognitions associated with problematic Smartphone use (PSU) have been scarcely investigated and measures to assess these beliefs are not yet available. The goal of the present study was: (i) to develop the first self-report scale of metacognitions about Smartphone use; and (ii) to investigate its predictive validity with respect to PSU. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106484DOI Listing

Social capital and health: a meta-analysis.

J Health Econ 2020 Jun 1;72:102317. Epub 2020 Jun 1.

College of Business and Law, University of Canterbury, New Zealand.

The relationship between social capital and health has received extensive attention in fields such as public health, medicine, epidemiology, gerontology and other health-related disciplines. In contrast, the economics literature on this subject is relatively small. To address this research gap, we investigate the cross-disciplinary empirical literature using meta-analysis. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2020.102317DOI Listing

Shaping Our Understanding of Medulloblastoma: A Bibliometric Analysis of the 100 Most Cited Articles.

Clin Neurol Neurosurg 2020 May 23;194:105895. Epub 2020 May 23.

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States. Electronic address:

The clinical management of medulloblastoma has undergone significant transformation since the recent dawn of the molecular era. The aim of this analysis was to evaluate citation and other bibliometric characteristics of the 100 most cited medulloblastoma articles in the literature to better understand the current state of our research efforts into this diagnosis. Elsevier's Scopus database was searched for the 100 most cited articles that focused on medulloblastoma. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105895DOI Listing

Six molecular patterns leading to hemophilia A phenotype in 18 females from Poland.

Thromb Res 2020 May 28;193:9-14. Epub 2020 May 28.

Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Poland.

Introduction: Female hemophilia is an intriguing rare disorder and few larger reports on its genetic etiology are available. While historically the diagnosis was satisfactorily reached by factor VIII activity assays, the clinical and potentially therapeutic heterogeneity of female hemophilia calls for comprehensive molecular diagnosis in each case. Currently, the genetic investigations are not a part of routine, state-funded, diagnostics in Poland, and thus molecular epidemiological data are missing. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.05.041DOI Listing

Stability of protoanemonin in plant extracts from Helleborus niger L. and Pulsatilla vulgaris Mill.

J Pharm Biomed Anal 2020 May 20;188:113370. Epub 2020 May 20.

WALA Heilmittel GmbH, Dorfstrasse 1, D-73087 Bad Boll/Eckwaelden, Germany.

The concentration levels and stability of protoanemonin, a characteristic constituent of Ranunculaceae species with antimicrobial and fungicidal properties, were studied for the first time in plant extracts prepared from Helleborus niger L. and Pulsatilla vulgaris Mill. using fermentative production processes. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113370DOI Listing

Arctic snow pollution: A GC-HRMS case study of Franz Joseph Land archipelago.

Environ Pollut 2020 May 27;265(Pt B):114885. Epub 2020 May 27.

Lomonosov Moscow State University, Chemistry Department, Leninskie Gory 1/3, Moscow, 119991, Russia; Lomonosov Northern (Arctic) Federal University, Core Facility Center "Arktika", Nab. Severnoy Dviny 17, Arkhangelsk, 163002, Russia. Electronic address:

Anthropogenic pollution of the Arctic atmosphere is of great interest due to the vulnerability of the Arctic ecosystems, as well as the processes of global transport and accumulation of atmospheric aerosols at high latitudes under conditions of cold climate. The present work throws light upon chemical composition of Arctic snow as a natural deposition matrix for atmospheric semi-volatile pollutants taken from the northernmost Arctic archipelago - Franz Josef Land, which is least affected by local sources of pollution and being a unique unstudied environmental object. The used methodology involved the liquid-liquid extraction of snow samples with dichloromethane and combination of targeted and non-targeted analyses of semi-volatile organic compounds with comprehensive two-dimensional gas chromatography - high-resolution mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114885DOI Listing

Enhanced vertebra to disk ratio as a new semi-quantitative imaging biomarker for Gaucher disease patients.

Eur J Radiol 2020 May 26;129:109091. Epub 2020 May 26.

Department of Radiology, Centre Antoine Lacassagne, Avenue de Valombrose, 06000, Nice, France. Electronic address:

Purpose: Gaucher disease (GD) is an inherited lysosomal storage disorder. The Vertebral Disk Ratio (VDR) is a semi-quantitative imaging biomarker designed to diagnose and monitor GD. Computed from standard T1 MRI images, the VDR is derived from 2D segmentations. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109091DOI Listing

Chemical and physical properties of nanocrystalline chitosan by the method: Modified nanochitosan complex and process of obtaining modified nanochitosan.

Carbohydr Res 2020 May 21;493:108035. Epub 2020 May 21.

Laboratory of Biomaterials, Materials Engineering Department, Federal University of Rio Grande Do Sul - UFRGS, Porto Alegre, RS, Brazil.

Nanocrystalline chitosan (NCC) is a modified form of chitosan, prepared from the method for obtaining chitosan acetate (CA). Due to the greater crystallinity of chitosan nanoparticles in relation to CA, NCC is more thermally stable and thus has great potential in the development of a new generation of biomaterials potentially useful in regenerative medicine and tissue engineering. NCC is also characterized by having similar properties to its precursor chitosan, such as its biocompatibility, bioactivity, ability to be bioabsorbed and lack of toxicity. Read More

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http://dx.doi.org/10.1016/j.carres.2020.108035DOI Listing

Cultivable non-starter lactobacilli from ripened Parmigiano Reggiano cheeses with different salt content and their potential to release anti-hypertensive peptides.

Int J Food Microbiol 2020 May 29;330:108688. Epub 2020 May 29.

Department of Life Sciences, University of Modena and Reggio Emilia, Via Amendola 2, 42122 Reggio Emilia, Italy. Electronic address:

The impact of salt and fat intake on human health drives the consumer's attention towards dairy food with reduced salt and fat contents. How changes in salt and fat content modulate dairy LAB population and the associated proteolytic activities have been poorly studied. Here, non-starter LAB populations from 12 Parmigiano Reggiano (PR) cheeses (12-month ripened), clustered in low salt and fat content (LL-PR) and high salt and fat content (HH-PR) groups, were investigated and identified at specie-level with molecular assays. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108688DOI Listing

Depressive symptoms effect subjective sleep quality in Chinese patients with Parkinson's disease.

Clin Neurol Neurosurg 2020 May 21;195:105950. Epub 2020 May 21.

Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China. Electronic address:

Objectives: The objective of this paper was aimed to estimate the influence of depressive symptoms on subjective sleep quality in Chinese PD patients.

Patients And Methods: A sample of 491 PD patients was collected and studied in the present study. Depressive symptoms were assessed using the Hamilton Rating Scale for Depression (HAMD). Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105950DOI Listing

The moving of high emission for biomass burning in China: View from multi-year emission estimation and human-driven forces.

Environ Int 2020 Jun 1;142:105812. Epub 2020 Jun 1.

Department of Environmental Science and Technology, School of Environmental Studies, China University of Geosciences, Wuhan 430074, China; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, China. Electronic address:

Biomass burning (BB) has significant impacts on air quality, climate and human health. In China, the BB emission has changed substantially over the past decades while the multi-year variation held high uncertainty and the driving forces have addressed little attention. Here, this research aimed to conduct a comprehensive and systematic analysis of BB variation in China and provided precise and targeted BB emission reduction suggestions. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105812DOI Listing
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