7,846,732 results match your criteria Analysis & Pde[Journal]

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Frequent nonrandom shifts in the temporal sequence of developmental landmark events during teleost evolutionary diversification.

Evol Dev 2019 Apr 18:e12288. Epub 2019 Apr 18.

Department of Genetics, SOKENDAI (The Graduate University for Advanced Studies), Mishima, Shizuoka, Japan.

Morphological transformations can be generated by evolutionary changes in the sequence of developmental events. In this study, we examined the evolutionary dynamics of the developmental sequence on a macroevolutionary scale in teleosts. Using the information from previous reports describing the development of 31 species, we extracted the developmental sequences of 19 landmark events involving the formation of phylogenetically conserved body parts; we then inferred ancestral developmental sequences by two different parsimony-based methods-event-pairing and continuous analysis. Read More

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http://dx.doi.org/10.1111/ede.12288DOI Listing
April 2019
3 Reads

PTEN-deficient prostate cancer is associated with an immunosuppressive tumor microenvironment mediated by increased expression of IDO1 and infiltrating FoxP3+ T regulatory cells.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Cancer Biology and Genetics, Queen's Cancer Research Institute, Queen's University, Kingston, Canada.

Background: Accumulating evidence shows that tumor cell-specific genomic changes can influence the cross talk between cancer cells and the surrounding tumor microenvironment (TME). Loss of the PTEN tumor suppressor gene is observed in 20% to 30% of prostate cancers (PCa) when first detected and the rate increases with PCa progression and advanced disease. Recent findings implicate a role for PTEN in cellular type I interferon response and immunosuppression in PCa. Read More

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http://dx.doi.org/10.1002/pros.23808DOI Listing

Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

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http://doi.wiley.com/10.1002/14651858.CD011875.pub2
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http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
April 2019
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Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois.

Background: Prostatic inflammation and various proinflammatory systemic comorbidities, such as diabetes and obesity are associated with human benign prostatic hyperplasia (BPH). There is a paucity of in vivo models reflecting specific aspects of BPH pathogenesis. Our aim was to investigate the nonobese diabetic (NOD) mouse as a potential model for subsequent intervention studies. Read More

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http://dx.doi.org/10.1002/pros.23809DOI Listing
April 2019
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Effects of Homeopathic Phosphorus on Encephalitozoon cuniculi-Infected Macrophages In-Vitro.

Homeopathy 2019 Apr 18. Epub 2019 Apr 18.

Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil.

Introduction:   (), a fungus that acts as an intracellular pathogen, causes a marked neurological syndrome in many host species and is a zoonotic concern. Although no well-established treatment for this syndrome is known, previous successful clinical experience using homeopathic phosphorus has been described in which symptom remission with no mortality occurred in 40/42 animals by means of unknown immunological mechanisms. The latter observation was the main motivation for this study. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678700
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http://dx.doi.org/10.1055/s-0039-1678700DOI Listing
April 2019
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Optimization of Whole-Body CT Examinations of Polytrauma Patients in Comparison with the Current Diagnostic Reference Levels.

Rofo 2019 Apr 18. Epub 2019 Apr 18.

Department of Diagnostic and Interventional Radiology, University-Hospital Giessen, Justus-Liebig-University Giessen, Germany.

Purpose:  Evaluation of the dose values of a polytrauma whole-body CT examination used in clinical practice with regard to the 2016 updated diagnostic reference levels and reduction of the mean exposure levels using simple optimization steps.

Materials And Methods:  In each case, 100 exposure values before and after dose optimization were compared with the old and new diagnostic reference levels. The grayscale values and the signal-to-noise ratio (SNR) were determined for the lung, the aortic arch and the liver. Read More

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http://dx.doi.org/10.1055/a-0881-3113DOI Listing

[Melanosis of adipose tissue in a 17-month-old German Fleckvieh bull (Bos taurus)].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2019 Apr 18;47(2):121-124. Epub 2019 Apr 18.

Fleischygieneamt.

At meat inspection of a 17-month-old bull (German Fleckvieh), patchy dark discoloration of various organs and tissue sites was noted that was most prominent in perirenal adipose tissue. Microscopic analysis revealed melanosis, that is a congenital melanocytic dystopia, as the underlying cause. To the best of our knowledge, this is the first case of melanosis detected in adipose tissue in cattle. Read More

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http://dx.doi.org/10.1055/a-0866-6421DOI Listing

Plication versus Resection in Horizontal Strabismus Surgery.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):442-445. Epub 2019 Apr 18.

University Eye Hospital Basel, Basel, Switzerland.

Background: To compare two commonly used strengthening procedures in strabismus surgery: plication and resection of the extraocular muscle (EOM).

Patients And Methods: From an anonymous databank of strabismus surgeries, performed at the University Eye Hospital Basel, patients with a horizontal strabismus surgery, consisting of a recession combined with either plication or resection of the antagonist and a follow-up of at least 3 months, were included. Exclusion criteria were previous eye surgeries, binocular surgeries, and simultaneous surgery of oblique or vertical EOM. Read More

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http://dx.doi.org/10.1055/a-0829-6086DOI Listing

The Use of Junfeng BFS Water (JBW) in Dry Eye Syndrome.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):366-370. Epub 2019 Apr 18.

Augenklinik, Otto von Guericke Universität Magdeburg, Magdeburg, Germany.

Background And Purpose: Junfeng BFS Water (JBW) is normal drinking water treated by an extremely low frequency electromagnetic field with certain electromagnetic oscillations. This leads to a change in physical water properties, such as an increase in permittivity and an increase in dissolved oxygen. Animal studies show that JBW has certain biological effects, such as improvement in microcirculation, cell hydration, and blood rheology. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0838-4836
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http://dx.doi.org/10.1055/a-0838-4836DOI Listing
April 2019
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Evaluation of the Relationship Between Type II Diabetes Mellitus and the Prevalence of Apical Periodontitis in Root-Filled Teeth Using Cone Beam Computed Tomography: An Observational Cross-Sectional Study.

Med Princ Pract 2019 Apr 19. Epub 2019 Apr 19.

Objective: This study aimed to investigate the prevalence of apical periodontitis (AP) in type II diabetic (DM) patients with either optimal glycemic control (OGC) or poor glycemic control (PGC) compared with nondiabetics using cone-beam computed tomography (CBCT).

Subjects And Methods: The periapical status of 75 teeth with adequate root canal treatment performed at least one year ago that could be visualized in the field of view of CBCT images of 43 DM patients (29 females, 14 males) were compared with a control group consisting of 162 teeth of 86 nondiabetics (56 females, 30 males). In addition, the DM group was divided into subgroups according to the patients' mean glycated hemoglobin level as either having OGC or PGC. Read More

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http://dx.doi.org/10.1159/000500472DOI Listing

Seasonality in Mortality in a Cardiology Department: A Five-Year Analysis in 500 Patients.

Cardiology 2019 Apr 18;142(2):67-72. Epub 2019 Apr 18.

Servicio de Cardiología, Hospital Universitario Gregorio Marañón, CIBERCV, Madrid, Spain,

Background: Previous studies have indicated that cardiovascular mortality follows a seasonal trend. The aim of this work was to determine the evolution of mortality throughout the year in a cardiology department.

Methods: All admissions and deaths occurring in our Cardiology Department over a 5-year period (2013-2017) were recorded retrospectively. Read More

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https://www.karger.com/Article/FullText/497815
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http://dx.doi.org/10.1159/000497815DOI Listing
April 2019
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Towards an Integrated Curriculum in a Speech and Language Pathology Education Programme: Development and Constituents' Initial Responses.

Folia Phoniatr Logop 2019 Apr 18:1-12. Epub 2019 Apr 18.

Division of Speech and Language Pathology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Background: A traditional curricular structure may challenge integration between foundational and clinical sciences in speech and language pathology (SLP) education. This project aimed to increase curriculum integration at a Swedish SLP education programme.

Methods: Learning outcomes in the existent curriculum were copied from their original courses and re-structured with reference to vertical tracks, in order to address them within and across years of study. Read More

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http://dx.doi.org/10.1159/000497609DOI Listing

Behavioral and Biochemical Features of the Course and Surgical Treatment of Experimental Obstructive Hydrocephalus in Young Rats.

Dev Neurosci 2019 Apr 18:1-10. Epub 2019 Apr 18.

Division of Pediatric Neurosurgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Introduction: Hydrocephalus is a multifactorial disease, affecting the dynamics of cerebrospinal fluid (CSF) and leading to severe neurological impairment in children; in spite of the recent advances in hydrocephalus research, it has many physiopathological aspects that still remain poorly understood, especially after treatment.

Objectives: To analyze the clinical, radiological, histopathological, and biochemical aspects of kaolin-induced hydrocephalus in an experimental model, both in the acute phase and after shunt treatment, by means of behavioral tests, magnetic resonance imaging (MRI) scans, histopathological studies, and level of inflammatory interleukins in the CSF.

Methods: Seven-day-old Wistar rats were used and subdivided into three subgroups: treated hydrocephalic (n = 24), untreated hydrocephalic (n = 17), and controls (n = 5). Read More

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http://dx.doi.org/10.1159/000497433DOI Listing

Assessment of Intermittent Self-Catheterization Procedures in Patients with Neurogenic Lower Urinary Tract Dysfunction: Dutch Translation and Validation of the Intermittent Catheterization Satisfaction Questionnaire, Intermittent Catheterization Acceptance Test, Intermittent Self Catheterization Questionnaire and Intermittent Catheterization Difficulty Questionnaire.

Urol Int 2019 Apr 18:1-6. Epub 2019 Apr 18.

Department of Urology, Ghent University Hospital, Ghent, Belgium.

Background: Intermittent self-catheterization (ISC) is by far the most appealing therapy to achieve a complete bladder emptying in patients with neurogenic lower urinary tract dysfunction (NLUTD). Four questionnaires have been developed in French in order to assess patient's satisfaction, difficulties and acceptance of this technique.

Objectives: The aim of this study was to translate, culturally adapt and validate Dutch versions of the Intermittent Catheterization Satisfaction Questionnaire (InCaSaQ), the Intermittent Catheterization Acceptance Test (ICAT), the Intermittent Self Catheterization Questionnaire (ISCQ) and the Intermittent Catheterization Difficulty Questionnaire (ICDQ). Read More

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http://dx.doi.org/10.1159/000499884DOI Listing

Sex Influence on the Efficacy and Safety of Sacubitril/Valsartan.

Cardiology 2019 Apr 18;142(2):73-78. Epub 2019 Apr 18.

Servicio de Cardiología, Hospital Universitario Gregorio Marañón, CIBERCV, Madrid, Spain,

Background: Women are underrepresented in sacubitril/valsartan (SV) clinical trials. The aim of this study was to assess sex-specific differences in efficacy, tolerability, and safety of SV in real-world heart failure with reduced ejection fraction (HFrEF) patients.

Methods: A prospective registry in 10 centers including all patients who started SV during the last 6 months was analyzed in this study. Read More

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http://dx.doi.org/10.1159/000498984DOI Listing

Functional Connectivity and Metabolic Alterations in Medial Prefrontal Cortex in a Rat Model of Fetal Alcohol Spectrum Disorder: A Resting-State Functional Magnetic Resonance Imaging and in vivo Proton Magnetic Resonance Spectroscopy Study.

Dev Neurosci 2019 Apr 18:1-12. Epub 2019 Apr 18.

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA,

Prenatal ethanol exposure alters brain structure, functional connectivity, and behavior in humans and rats. Behavioral changes include deficits in executive function, which requires cooperative activity between the frontal cortices and other brain regions. In this study, we analyzed the functional connectivity and neurochemical levels of the prefrontal cortex (PFC) using resting-state functional magnetic resonance imaging (rsfMRI) and proton magnetic resonance spectroscopy (1H-MRS) in ethanol-exposed (Eth) and control (Ctr) rats. Read More

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http://dx.doi.org/10.1159/000499183DOI Listing

Prognostic role of GPER/Ezrin in triple negative breast cancer is associated with menopausal status.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

T Wang, Department of Physiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

The role of G protein-coupled estrogen receptor 1 (GPER) signaling including promoting Ezrin phosphorylation, which could be also activated by estrogen has not yet been clearly identified in triple negative breast cancer (TNBC). This study is to evaluate the prognostic value of GPER and Ezrin in TNBC patients. Clinico-pathologic features including age, menopausal status, tumor size, nuclear grade, lymph node metastasis, AJCC TNM stage and ER, PR, HER-2 expression were evaluated from 249 TNBC cases. Read More

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https://ec.bioscientifica.com/view/journals/ec/aop/ec-19-016
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http://dx.doi.org/10.1530/EC-19-0164DOI Listing
April 2019
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Multiplatform metabolomics provides insight into the molecular basis of chronic kidney disease.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 3;1117:49-57. Epub 2019 Apr 3.

Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Changes in metabolites composition can reflect currently present pathological processes in a living organism and constitute a basis for diagnosis and treatment improvements. Thus, the multiplatform metabolomics approach was applied for the investigation of molecular mechanisms of chronic kidney disease (CKD) progression. The high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS) and gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ/MS) serum metabolic fingerprinting followed by uni- and multivariate statistical analysis was carried out to determine metabolic pattern differentiating CKD patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.003DOI Listing

Machine learning and big data in psychiatry: toward clinical applications.

Curr Opin Neurobiol 2019 Apr 15;55:152-159. Epub 2019 Apr 15.

Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, England, United Kingdom; Division of Psychiatry, University College London, London, England, United Kingdom; Camden and Islington NHS Foundation Trust, London, England, United Kingdom. Electronic address:

Psychiatry is a medical field concerned with the treatment of mental illness. Psychiatric disorders broadly relate to higher functions of the brain, and as such are richly intertwined with social, cultural, and experiential factors. This makes them exquisitely complex phenomena that depend on and interact with a large number of variables. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09594388183008
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http://dx.doi.org/10.1016/j.conb.2019.02.006DOI Listing
April 2019
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Performance of stair negotiation in patients with cerebral palsy and stiff knee gait.

Gait Posture 2019 Apr 9;71:14-19. Epub 2019 Apr 9.

Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany; Pediatric Orthopaedics and Traumatology, University, Children's Hospital Zurich - Eleonore Foundation, Steinwiesstrasse 75, 8032 Zurich, Switzerland. Electronic address:

Background: Due to the limited knee range of motion, achieving adequate foot clearance while walking on level ground constitutes a major problem for patients with cerebral palsy and stiff knee gait. Stair negotiation as an activity of daily life requires a considerably higher knee range of motion than level ground walking, but little is known yet as to whether such patients are able to walk stairs.

Research Question: The aim of this study was to investigate how patients with a limited knee range of motion negotiate stairs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183178
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http://dx.doi.org/10.1016/j.gaitpost.2019.04.005DOI Listing
April 2019
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Green microalgae for combined sewage and tannery effluent treatment: Performance and lipid accumulation potential.

J Environ Manage 2019 Apr 15;241:167-178. Epub 2019 Apr 15.

Department of Environmental and Water Resources Engineering, School of Civil Engineering, Vellore Institute of Technology (VIT), Vellore, 632014, India. Electronic address:

Microalgae have considerable interest owing to its phycoremediation potential and raw material for sustainable biofuel production. In this study, the performance of green algae Chlorella vulgaris (NRMCF0128) and Pseudochlorella pringsheimii (VIT_SDSS) was evaluated for the remediation of combined sewage and tannery effluent under different dilutions. Significant reduction in pollutant concentration was observed in the effluent: >65% for NH-N, 100% for PO-P, >63% for COD & >80% for total chromium, at higher dilutions (up to 30%) of tannery effluent (T) for both species. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.04.031DOI Listing

Overview of bioremediation with technology assessment and emphasis on fungal bioremediation of oil contaminated soils.

J Environ Manage 2019 Apr 15;241:156-166. Epub 2019 Apr 15.

PROFNIT - Professional Post-Graduate Program in Intellectual Property and Technology Transfer for Innovation, Federal University of Bahia, Campus de Ondina, R. Barão de Jeremoabo, 147, Ondina, Salvador, BA, 40170-115, Brazil; José de Anchieta College, Av. João Durval Carneiro, n. 3039, São João, Feira de Santana, BA, 44051-605, Brazil. Electronic address:

Environmental contamination is a problem that requires sustainable solutions. Bioremediation technologies have been developed in the last decades and are increasingly used to mitigate environmental accidents and systematic contaminations. A review of bioremediation technologies, based on published article and patent documents, is presented for different types of contaminated matrices, bioremediation agents and contaminants. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.04.019DOI Listing

Thermo-ecological analysis of industrial kilns.

J Environ Manage 2019 Apr 15;241:149-155. Epub 2019 Apr 15.

Department of Mechanical Engineering, Faculty of Engineering, Usak University, 64200, Usak, Turkey. Electronic address:

In this study, thermo-ecological analysis has been applied by using ecologic objective function "ECO" and ecological coefficient of performance "ECOP" to the kilns used in the firing process of the ceramic plant. Five different environmental (dead state) temperatures (between 10 °C and 30 °C) are taken into account. The irreversibility, which are the most important criteria affecting ecological performance, occurs during the heat transfer in the burners and cooling in the kiln. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.04.032DOI Listing

Determining of risk areas due to exposure to heavy metals in the Toluca Valley using epiphytic mosses as a biomonitor.

J Environ Manage 2019 Apr 15;241:138-148. Epub 2019 Apr 15.

Dirección de Investigación Científica, Instituto Nacional de Investigaciones Nucleares, A. P. 18-1027, Col. Escandón, Delegación Miguel Hidalgo, C. P. 11801, México, D. F., Mexico.

The work aim is to identify the risk areas by exposure to Cr, Cu, Pb and Zn in the Metropolitan Zone of Toluca Valley (MZTV) using the mosses Fabriona cilaris and Leskea angustata as a biomonitors, geostatistical interpolation and multi-criteria evaluation by analytical hierarchy process. The results from the estimation of the enrichment factors (EF) showed that Pb is the heavy metal with the highest values, followed by the Zn, Cu and Cr. The EF obtained for all heavy metals show that there is a moderate to high anthropogenic enrichment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03014797193047
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http://dx.doi.org/10.1016/j.jenvman.2019.04.018DOI Listing
April 2019
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Meningioma and psychiatric symptoms: An individual patient data analysis.

Asian J Psychiatr 2019 Mar 28;42:94-103. Epub 2019 Mar 28.

Department of Psychiatry, Dr Ram Manohar Lohia Hospital PGIMER, New Delhi, India.

Meningioma is a slow-growing benign tumor arising from meninges and is usually asymptomatic. Though neuropsychiatric symptoms are common in patients with brain tumors, they often can be the only manifestation in cases of meningioma. Meningiomas might present with mood symptoms, psychosis, memory disturbances, personality changes, anxiety, or anorexia nervosa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18762018183113
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http://dx.doi.org/10.1016/j.ajp.2019.03.029DOI Listing
March 2019
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Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

Epilepsy Res 2019 Mar 29;153:59-65. Epub 2019 Mar 29.

Sunovion Pharmaceuticals Inc., 84 Waterford Drive, Marlborough, MA, 01752, USA.

Objective: To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS).

Methods: Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study 045 or 046, patients started on ESL 1600 mg once daily (QD) (or 1200 mg if they previously had a dose reduction), and could adjust the dose 400 mg/week to a dose between 800-2400 mg QD. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.018DOI Listing

'When the dog bites': What can we learn about health geography from newspaper coverage in a 'model city' for dog-bite prevention?

Health Place 2019 Apr 15;57:70-73. Epub 2019 Apr 15.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Canada; Faculty of Social Work, University of Calgary, Canada.

Despite calls for the adoption of 'One-Health' approaches, dog-bite injuries remain neglected in healthcare and public health, and our study may help to understand why. Media coverage can influence policy directions, including policies that address dogs. We collected articles (n = 65) published in two local newspapers, 2012-2017, then carried out an ethnographically-informed discourse analysis of the dog-bite reports. Read More

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http://dx.doi.org/10.1016/j.healthplace.2019.03.001DOI Listing

Activated carbon fiber for adsorption/electrodeposition of Cu (II) and the recovery of Cu (0) by controlling the applied voltage during membrane capacitive deionization.

J Colloid Interface Sci 2019 Apr 10;548:160-169. Epub 2019 Apr 10.

Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes, Hohai University, Nanjing 210098, China; College of Environment, Hohai University, Nanjing 210098, China.

Membrane capacitive deionization (MCDI) as a promising approach was developed to simultaneously conduct water desalination and metal recovery by using activated carbon fiber (ACF) as electrodes. The removal performance of two metal ions (Cu, Zn) was firstly investigated at different voltages. Experiments showed that the adsorption amount of Cu was higher than that of Zn under the voltage of 0. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.04.030DOI Listing

In silico analysis of different signal peptides for the secretory production of recombinant human keratinocyte growth factor in Escherichia coli.

Comput Biol Chem 2019 Mar 29;80:225-233. Epub 2019 Mar 29.

Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: The recombinant human truncated Keratinocyte growth factor (Palifermin) is the only FDA approved medicine for the treatment of oral mucositis. The Keratinocyte growth factor is a fairly unstable protein due to its high aggregation propensity and therefore its expression as a secretory protein may results in the production of a protein with more stability, higher solubility, better folding, enhanced biological activity, N-terminal authenticity and simplified downstream processing.

Objective: The aim of this study was in silico evaluation of 31 different secretory signal peptides to determine the best theoretical candidates for the secretory production of recombinant truncated human KGF in E. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.03.003DOI Listing

De novo glycan structural identification from mass spectra using tree merging strategy.

Comput Biol Chem 2019 Mar 30;80:217-224. Epub 2019 Mar 30.

Key Lab of Intelligent Information Processing, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Motivation: Glycans are large molecules with specific tree structures. Glycans play important roles in a great variety of biological processes. These roles are primarily determined by the fine details of their structures, making glycan structural identification highly desirable. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.03.015DOI Listing

Vieloplains A-G, seven new guaiane-type sesquiterpenoid dimers from Xylopia vielana.

Bioorg Chem 2019 Apr 10;88:102891. Epub 2019 Apr 10.

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; Institute of Interdisciplinary Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China. Electronic address:

Seven new guaiane-type sesquiterpene dimers vieloplains A-G, connecting patterns through three different direct CC bonds compounds 1-5 (C-3 to C-3', C-4 to C-1'), compound 6 (C-2 to C-3', C-4 to C-2') and compound 7 (C-2 to C-1', C-4 to C-2') were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOESY analysis, the Cu Kα X-ray crystallographic the experiment circular dichroism (ECD) and the calculated ECD. Among them, only compound 6 showed a considerable cytotoxicity against DU145 cells with IC values of 9. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.03.065DOI Listing

Sampling and multiplexing in lab-on-paper bioelectroanalytical devices for glucose determination.

Biosens Bioelectron 2019 Apr 5;135:64-70. Epub 2019 Apr 5.

Departamento de Química Física y Analítica, Facultad de Química, Universidad de Oviedo, 33006, Oviedo, Spain. Electronic address:

In this work, we present a multiplexed (eight simultaneous measurements) paper-based electrochemical device developed in a very simple way and using low-cost materials, such as paper, carbon ink and multifunctional connector headers. Meanwhile, we have also combined the paper-based electrochemical platform with a glass-fiber strip in order to integrate easily a sampling step. Both approaches, simultaneous measuring and sampling, have been applied to the determination of glucose using bienzymatic biosensors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193028
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http://dx.doi.org/10.1016/j.bios.2019.04.006DOI Listing
April 2019
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Cost-Effectiveness of Negative Pressure Incision Management System in Cardiac Surgery.

J Surg Res 2019 Apr 15;240:227-235. Epub 2019 Apr 15.

Division of Thoracic & Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia.

Background: Sternal wound infections (SWIs) can be a devastating long-term complication with significant morbidity and health care cost. The purpose of this analysis was to evaluate the cost-effectiveness of negative pressure incision management systems (NPIMS) in cardiac surgery.

Materials And Methods: All cardiac surgery cases at an academic hospital with risk scores available (2009-2017) were extracted from an institutional database (n = 4455). Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.046DOI Listing

A method for the cell-cycle-specific analysis of radiation-induced chromosome aberrations and breaks.

Mutat Res 2019 Apr 6;815:10-19. Epub 2019 Apr 6.

Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, Essen, Germany. Electronic address:

The classical G-assay is widely used to assess cell-radiosensitivity and cancer phenotype: Cells are exposed to low doses of ionizing-radiation (IR) and collected for cytogenetic- analysis ˜1.5 h later. In this way, chromosome-damage is measured in cells irradiated in G-phase, without retrieving information regarding kinetics of chromosome-break-repair. Read More

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http://dx.doi.org/10.1016/j.mrfmmm.2019.04.001DOI Listing
April 2019
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Rapid quantitative analysis of ginkgo flavonoids using paper spray mass spectrometry.

J Pharm Biomed Anal 2019 Apr 10;171:158-163. Epub 2019 Apr 10.

Key Laboratory of Phytochemical R&D of Hunan Province and Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, PR China.

In this work, a method for the rapid and reliable analysis of ginkgo flavonoids was developed by using paper spray mass spectrometry (PS-MS) assisted by microwave-assisted hydrolysis (MAH). Kaempferol-D, quercetin-D, and isorhamnetin-D were used as internal standards (IS). Samples analyses were completed by simply treating with extraction, MAH, dilution, and quantitative analysis by PS-MS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183281
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http://dx.doi.org/10.1016/j.jpba.2019.04.018DOI Listing
April 2019
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Bioavailable Sr/Sr in European soils: A baseline for provenancing studies.

Sci Total Environ 2019 Mar 31;672:1033-1044. Epub 2019 Mar 31.

Eurogeosurveys, Brussels, Belgium.

We present Sr/Sr isotope ratios for ~1200 selected soil samples, collected by the GEMAS consortium from grazing (Gr) and agricultural (Ap) soils in Europe with the aim to better understand the strontium isotope distribution in the bioavailable fraction of the top-soil and its potential for provenancing applications. Spatial analysis shows that there is a clear distinction between coastal (<100 km) and non-coastal (>100 km) samples in their variance and that this variance is mirrored in the sodium concentration, suggesting an important but highly variable contribution from seaspray. We present two Sr/Sr maps at 25 km × 25 km scale: one based solely on the measured data using a classical kriging approach and one based on a Random Forest model using complementary GEMAS data to predict the strontium isotope composition at the remaining 3000+ GEMAS sampling locations, including appropriate uncertainty assessment. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.387DOI Listing
March 2019
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Clinical analysis of syringomyelia resulting from spinal hemangioblastoma in a single series of 38 consecutive patients.

Clin Neurol Neurosurg 2019 Apr 1;181:58-63. Epub 2019 Apr 1.

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan province, 450052, PR China; Key laboratory of Neurosurgical Diseases, The First Affiliated Hospital of Zhengzhou University, Jianshe East Road, NO 1, Zhengzhou, Henan Province, 450052, PR China. Electronic address:

Objective: Syringomyelia was predominantly caused by Chiari malformation or intramedullary ependymoma. The goal of this study was to identify factors related to clinical outcomes and spinal hemangioblastoma (SH)-induced syringomyelia formation in a single series of patients.

Patient And Methods: Thirty-eight patients with SH were treated with microsurgery from January 2013 to December 2018. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.03.025DOI Listing

Elucidating the biodegradation mechanism of tributyl phosphate (TBP) by Sphingomonas sp. isolated from TBP-contaminated mine tailings.

Environ Pollut 2019 Apr 3;250:284-291. Epub 2019 Apr 3.

School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing, 100083, PR China; Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants, Beijing, 100083, China.

Tributyl phosphate (TBP) is recognised as a global environmental contaminant because of its wide use in floatation reagents, nuclear fuel reprocessing and plasticisers. This contaminant is hardly degraded by hydrolysis in the environment due to its special physicochemical properties. In this study, one TBP-degrading strain was isolated from TBP-contaminated abandoned mine tailings, and 16S rRNA identification revealed that the strain belonged to the genus Sphingomonas. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.127DOI Listing

Mediation of functional gene and bacterial community profiles in the sediments of eutrophic Chaohu Lake by total nitrogen and season.

Environ Pollut 2019 Apr 10;250:233-240. Epub 2019 Apr 10.

CAS Key Laboratory of Urban Pollutant Conversion, Department of Applied Chemistry, University of Science & Technology of China, Hefei, 230026, China. Electronic address:

Microbes in sediments contribute to nutrient release and play an important role in lake eutrophication. However, information about the profiles of functional genes and bacterial communities and the most important environmental factor affecting them in the sediments of eutrophic lake remains unrevealed. In this work, the real-time fluorescent quantitative polymerase chain reaction (qPCR) assay and 16S ribosomal RNA gene next generation sequencing analysis were used to explore the profiles of functional genes and bacterial communities in the sediments of Chaohu Lake. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.028DOI Listing

Cost-benefit analysis of the use of tranexamic acid in total replacement hip surgery.

J Clin Anesth 2019 Apr 15;57:124-128. Epub 2019 Apr 15.

Office of Health Economics, London, UK.

Study Objective: To establish the best dose regimen for tranexamic acid (TXA) in total hip replacement surgery.

Design: Secondary analysis based on data from a multicenter double-blind randomized clinical trial.

Setting: Two hospitals in Spain. Read More

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http://dx.doi.org/10.1016/j.jclinane.2019.04.006DOI Listing

Optimization of operating conditions of miniaturize single chambered microbial fuel cell using NiWO/graphene oxide modified anode for performance improvement and microbial communities dynamics.

Bioresour Technol 2019 Apr 11;285:121337. Epub 2019 Apr 11.

School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, U.P. 221005, India. Electronic address:

NiWO and graphene oxide (NWG) modified anodic carbon cloth (CC) is used to improve the performance of single chambered microbial fuel cell (SMFC) by statistical optimization of operational parameters. The properties of synthesized NWG nanocomposite on the surface of modified anode are characterized by FTIR, XRD, EDX, TEM and SEM analysis. The optimum level of operational parameters maximize the power density (PD) 1458 mW/m of SMFC having NWG modified anode and observed 8. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.121337DOI Listing

Degradation pathways and kinetics of anthraquinone compounds along with nitrate removal by a newly isolated Rhodococcus pyridinivorans GF3 under aerobic conditions.

Bioresour Technol 2019 Apr 11;285:121336. Epub 2019 Apr 11.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.

A novel Rhodococcus pyridinivorans GF3 capable of degrading anthraquinone compounds (ACs) was isolated from 1-amino-4-bromoanthraquinone-2-sulfonic acid contaminated soil under aerobic conditions. Strain GF3 could degrade nine ACs at 150 rpm and 30 °C. LC-MS analysis showed that ACs were degraded via catechol and salicylic acid-produced pathways, which were different from previously reported phthalic acid-produced pathway. Read More

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April 2019
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Chronic exposure to green light aggravates high-fat diet-induced obesity and metabolic disorders in male mice.

Ecotoxicol Environ Saf 2019 Apr 15;178:94-104. Epub 2019 Apr 15.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, PR China; School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, PR China. Electronic address:

Light is involved in many critical physiological or biochemical processes of human beings, such as visual sensing and the production of vitamin D. Recent studies have showed that the lights of different wavelengths have a profound influence in life activities. For example, blue light promotes alertness, whereas green light (GL) induces sleep in mice. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.013DOI Listing

Association of wheat chaff derived silica fiber and esophageal cancer in north China.

Ecotoxicol Environ Saf 2019 Apr 15;178:79-85. Epub 2019 Apr 15.

School of Public Health, The University of Hong Kong, 7 Sassoon Road, Hong Kong SAR, China. Electronic address:

Background: Despite decades of research and intervention programs, the epidemic of esophageal squamous cell carcinoma (ESCC) in the Taihang Mountain area of north China has not seen convincing explanation by any risk factor yet and the incidence has not seen a substantial decrease. Based on recently disclosed association of aridity and wheat consumption with esophageal cancer, we revisited the hypothesis of biogenic silica in esophageal cancer development.

Methods: From the archives of the Pathology Department of Heping Hospital, Changzhi Medical College, we selected three pairs of formalin-fixed samples, tumor tissues and distant normal tissues, of three patients operated for ESCC who had no history of workplace exposure to silica dust. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.031DOI Listing
April 2019
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Insights into selenate removal mechanism of hydrogen-based membrane biofilm reactor for nitrate-polluted groundwater treatment based on anaerobic biofilm analysis.

Ecotoxicol Environ Saf 2019 Apr 15;178:123-129. Epub 2019 Apr 15.

College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China. Electronic address:

The selenate removal mechanism of hydrogen-based membrane biofilm reactor (MBfR) for nitrate-polluted groundwater treatment was studied based on anaerobic biofilm analysis. A laboratory-scale MBfR was operated for over 60 days with electron balance, structural analysis, and bacterial community identification. Results showed that anaerobic biofilm had an excellent removal of both selenate (95%) and nitrate (100%). Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.005DOI Listing

Male workers' exposure characteristics of ΣPCDD/F from a municipal solid waste incinerator in south China through hair analysis.

Ecotoxicol Environ Saf 2019 Apr 15;178:105-112. Epub 2019 Apr 15.

South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou, 510000, China. Electronic address:

Human hair, flue gas and fly ash from a municipal solid waste incinerator (MSWI) in south China were collected and analyzed for polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF). The ΣPCDD/F level in hair from male workers were higher than those from residents. The Principal Component Analysis (PCA) suggested that ΣPCDD/F in flue gas is an external source of male workers' hair ΣPCDD/F. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.011DOI Listing

Evaluation of the genotoxicity of neurotoxic insecticides using the micronucleus test in Tradescantia pallida.

Chemosphere 2019 Apr 12;227:371-380. Epub 2019 Apr 12.

Institute of Biotechnology, Federal University of Uberlândia, Campus Umuarama, 38900-402, Uberlândia, Minas Gerais, Brazil.

Neonicotinoids and phenylpyrazoles are classes of neurotoxic insecticides which are able to bind at different ligand sites of neural receptors, leading to the deregulation of insect neural activity and hence resulting in death. The misuse or indiscriminate use of these chemicals is directly associated with several toxicological effects in biota and at different trophic levels. Based on this premise, the aim of the present study was to evaluate and compare the genotoxic capacity of different concentrations of thiamethoxam (TMX), acetamiprid (ACP), imidacloprid (IMI) and fipronil (FP) through the Micronucleus Test in Tradescantia pallida (Trad-MCN). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.073DOI Listing
April 2019
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