8,344,343 results match your criteria Analysis & Pde[Journal]

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TERT promoter mutation analysis as a surrogate to morphology and immunohistochemistry in problematic spindle cell lesions of the urinary bladder.

Histopathology 2020 Jul 9. Epub 2020 Jul 9.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.

Aims: Pseudosarcomatous myofibroblastic proliferations (PSMPs) of the urinary bladder are diagnostically challenging. Diagnostic difficulties are mainly due to frequent cytokeratin expression, variable ALK expression, and worrisome morphologic features suggestive of malignancy. On the opposite, sarcomatoid urothelial carcinoma (UC) may show bland inflammatory myofibroblastic tumor (IMT)-like morphology. Read More

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http://dx.doi.org/10.1111/his.14206DOI Listing

Outcomes and factors associated with early mortality in pediatric post-cardiotomy veno-arterial extracorporeal membrane oxygenation.

Artif Organs 2020 Jul 9. Epub 2020 Jul 9.

Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Mortality and morbidity of children received veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support after cardiac surgery remain high despite remarkable advances in medical management and devices. The purpose of this study was to describe outcomes and risk factors of applying VA-ECMO in the surgical pediatric population. We retrospectively analyzed 85 consecutive pediatric patients (aged <18 years) who received post-cardiotomy VA-ECMO from January 2010 to December 2018. Read More

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http://dx.doi.org/10.1111/aor.13773DOI Listing

Gene expression analysis of autofluorescence margins in leukoplakia and oral carcinoma: a pilot study.

Oral Dis 2020 Jul 9. Epub 2020 Jul 9.

Department of Health Sciences, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.

Objectives: Autofluorescence is considered a useful technique in the early detection of oral mucosal alterations. However, its efficacy to discriminate tumor margins is still under debate. The purpose of this pilot study was to confirm the existence of molecular divergence from the centre of a lesion compared to white light and autofluorescence (VELscope ) visualized margins in leukoplakia and oral carcinoma. Read More

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http://dx.doi.org/10.1111/odi.13525DOI Listing

Phenylalanine increases Chrysanthemum flower immunity against Botrytis cinerea attack.

Plant J 2020 Jul 9. Epub 2020 Jul 9.

Department of Ornamental Plants and Agricultural Biotechnology, Agricultural Research Organization, The Volcani Center, 68 HaMaccabim Road, P.O.B 15159, Rishon LeZion, 7505101, Israel.

Flowers are the most vulnerable plant organ to infection by the necrotrophic fungus, Botrytis cinerea. Here we show that pre-treatment of chrysanthemum flowers with phenylalanine (Phe) significantly reduces their susceptibility to B. cinerea. Read More

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http://dx.doi.org/10.1111/tpj.14919DOI Listing

Modelling of self-management in schizophrenia: The role of neurocognition, self-efficacy, and motivation.

J Clin Nurs 2020 Jul 9. Epub 2020 Jul 9.

School of Nursing, Peking Union Medical College, 33 Ba Da Chu Rd, Beijing, 100144, China.

Aims And Objectives: This study aimed to address the interrelationships among neurocognition, self-efficacy, motivation, and self-management in individuals with schizophrenia.

Background: Self-management performance of individuals with schizophrenia is relatively poor. The effect of neurocognitive impairment on self-management in schizophrenia remains inconsistent, which may be attributed to the neglect of possible mediating factors. Read More

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http://dx.doi.org/10.1111/jocn.15407DOI Listing

Short-term outcomes of lateral extraction socket augmentation using autogenous tooth roots. A prospective observational study.

Clin Oral Implants Res 2020 Jul 9. Epub 2020 Jul 9.

Department of Oral Surgery and Implantology, , Carolinum, Goethe University, Frankfurt, Germany.

Objectives: To assess the short-term clinical outcomes of lateral augmentation of deficient extraction sockets and two-stage implant placement using autogenous tooth roots (TR).

Material & Methods: A total of n=13 patients (13 implants) were available for the analysis. At the time of tooth extraction, each subject had received lateral augmentation using the respective non-retainable but non-infected tooth root where the thickness of the buccal bone was <0. Read More

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http://dx.doi.org/10.1111/clr.13633DOI Listing

Pain and disability in women with patellofemoral pain relates to kinesiophobia, but not to patellofemoral joint loading variables.

Scand J Med Sci Sports 2020 Jul 9. Epub 2020 Jul 9.

Department of Physiotherapy, School of Science and Technology, Sao Paulo State University (UNESP), Presidente Prudente, Brazil.

Background: Altered patellofemoral joint (PFJ) loading and elevated kinesiophobia are commonly reported in people with patellofemoral pain (PFP). However, the relative relationship of these physical-psychological variables with pain and disability in people with PFP is unknown.

Aim: To explore the relationship of PFJ loading during stair ascent and kinesiophobia, with self-reported pain and disability in women with PFP. Read More

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http://dx.doi.org/10.1111/sms.13767DOI Listing

Cytotoxic and Anti-inflammatory Terpenoids from the Whole Plant of Vaccinium emarginatum.

Planta Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.

Two new Δ ursene-type triterpenoid coumaroyl esters (1: and 2: ), one new Δ isopimarane-type diterpenoid glycoside (20: ), and two new irido--lactone-type iridoids (21: and 22: ), together with 17 known pentacyclic triterpenoids (3:  - 19: ), were isolated during the phytochemical investigation of a methanol extract of the whole plant of . Their structures were determined by detailed analysis of standard spectroscopic data (MS, IR, 1D, and 2D NMR) and comparison with data of known analogs. The isolates were evaluated for their cytotoxicity against the PC-3 and Du145 prostate cancer cell lines (as assessed by an MTT cell proliferation assay), as well as for their anti-inflammatory activity via the inhibition of nitric oxide production in lipopolysaccharide-induced murine macrophage RAW 264. Read More

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http://dx.doi.org/10.1055/a-1192-6225DOI Listing

Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets.

Planta Med 2020 Jul 9. Epub 2020 Jul 9.

Univ. Grenoble Alpes, CNRS, DPM, Grenoble, France.

is a European shrub growing at high altitude where it copes with a high level of stress. It was found to be overexpressed in ungulates diets compared to more abundant surrounding plants. These elements combined with the fact that from the Alps has never been investigated prompted us to study the phytochemical composition of its aerial parts. Read More

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http://dx.doi.org/10.1055/a-1197-2898DOI Listing

[Consulting Ethics Committees about a Multicenter Observational Study in Germany - A Report on Effort and Costs].

Gesundheitswesen 2020 Jul 9. Epub 2020 Jul 9.

Zertifizierung, Deutsche Krebsgesellschaft eV, Berlin.

Aim Of The Study: Ethics committees (ECs) have an indispensable monitoring and regulatory function in research on human beings. In multicenter observational studies, approvals of several local ECs are often required. The aim of this analysis was to provide an overview of the resources used and the process for consulting ECs about a multicenter observational study in Germany. Read More

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http://dx.doi.org/10.1055/a-1192-4946DOI Listing

[Balancing Work and Caregiving: Impact of Employment on the Health of Family Caregivers].

Gesundheitswesen 2020 Jul 9. Epub 2020 Jul 9.

Lehrstuhl für Management und Innovation im Gesundheitswesen, Universität Witten Herdecke, Witten.

Aim: The aim of this study was to investigate how the health effects of informal care are influenced by the contextual factor employment.

Methodology: The analysis is based on representative German population data for 2015 and 2016 (n=19 791). The focus group "family caregivers" includes persons who informally support or care for a person at least one hour a week. Read More

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http://dx.doi.org/10.1055/a-1173-8918DOI Listing

Resistance to Fracture of Zirconia Abutments with Different Angulations: Impact of Implant Platform Diameter.

Eur J Dent 2020 Jul 9. Epub 2020 Jul 9.

University of Zurich, Center of Dental Medicine, Division of Dental Biomaterials, Clinic for Reconstructive Dentistry, Zurich, Switzerland.

Objective:  The aim of this study was to assess the impact of implant platform diameters on ultimate force to failure of zirconia abutments with different angulation.

Materials And Methods:  Forty-two zirconia abutments with either 0 degree (ST) or 15-degree (AN) angulation were assembled on tapered internal connection titanium implants (Direct's Legacy; 13 mm Implant Direct, LLC, Las Vegas, United States) with a platform diameter of Ø3.0, Ø3. Read More

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http://dx.doi.org/10.1055/s-0040-1709947DOI Listing

In vitro Simulation of Periodontal Ligament in Fatigue Testing of Dental Crowns.

Eur J Dent 2020 Jul 9. Epub 2020 Jul 9.

Department of Applied Dental Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.

Objective:  Fatigue testing of restorative material has been appreciated as an appropriate method to evaluate dental restorations. This study aims to investigate the influence of periodontal ligament (PDL) simulation on fatigue and fracture tests results of zirconia crowns.

Materials And Methods:  A standard tooth preparation for all ceramic zirconia crown was made on a typodont mandibular molar. Read More

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http://dx.doi.org/10.1055/s-0040-1713953DOI Listing

Interfacial Fracture Toughness Comparison of Three Indirect Resin Composites to Dentin and Polyether Ether Ketone Polymer.

Eur J Dent 2020 Jul 9. Epub 2020 Jul 9.

Department of Restorative Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Objectives:  Advances in laboratory composites and their high wear resistance and fracture toughness have resulted in their growing popularity and increasing use for dental restorations. This study sought to assess the fracture toughness of three indirect composites bonded to dental substrate and polyether ether ketone (PEEK) polymer.

Materials And Methods:  This study was conducted on two groups of dental and polymer substrates. Read More

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http://dx.doi.org/10.1055/s-0040-1713309DOI Listing

Maternal Outcomes of Ongoing Pregnancies Complicated by Fetal Life-Limiting Conditions.

Am J Perinatol 2020 Jul 9. Epub 2020 Jul 9.

Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Objective:  This study aimed to examine maternal outcomes of ongoing pregnancies complicated by fetal life-limiting conditions.

Study Design:  This was a retrospective matched cohort study of women with a diagnosis of fetal life-limiting condition between 2010 and 2018 in a single academic center. Cases were matched to controls (women who had normal fetal anatomic survey) according to year of delivery, body mass index, and parity in a 1:4 ratio. Read More

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http://dx.doi.org/10.1055/s-0040-1713927DOI Listing

What Is the Prevalence of Measles Immunity among Pregnant Women?

Am J Perinatol 2020 Jul 9. Epub 2020 Jul 9.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount Sinai West, New York City, New York.

Objective:  This study aimed to estimate the prevalence of measles immunity in a cohort of pregnant women in New York City and determine if there is a positive correlation of measles immunity with patient demographics, rubella immunity, number of measles, mumps, and rubella vaccine (MMR) doses received, and age at last vaccination.

Study Design:  This is a cross-sectional study of pregnant patients seen at a single institution from January 2019 to May 2019. Patients were classified as measles and rubella immune or nonimmune using commercial immunoglobulin G (IgG) tests. Read More

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http://dx.doi.org/10.1055/s-0040-1713817DOI Listing

Assessment of Th1/Th2 cytokines among patients with Middle East respiratory syndrome coronavirus infection.

Int Immunol 2020 Jul 10. Epub 2020 Jul 10.

Research and Innovation Center, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia.

Middle East respiratory syndrome coronavirus (MERS-CoV) is a member of the beta-coronavirus genus of zoonotic origin that emerged in the Arabian Peninsula and is associated with significant morbidity and mortality. This study was conducted to assess the plasma levels of cytokines to evaluate the Th1/Th2 status among 46 MERS-CoV infected patients (19 asymptomatic and 27 symptomatic) and 52 normal healthy controls using a customized luminex kit. Comparative analysis of data between MERS-CoV infected patients and normal healthy controls revealed that whereas no difference was observed between asymptomatic MERS-CoV patients and controls, the mean plasma levels of IL-10 (44. Read More

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http://dx.doi.org/10.1093/intimm/dxaa047DOI Listing

Limiting factors of peak and submaximal exercise capacity in LVAD patients.

PLoS One 2020 9;15(7):e0235684. Epub 2020 Jul 9.

Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium.

Aims: Although patients supported with a Continuous-Flow Left Ventricular Assist Device (CF-LVAD) are hemodynamically stable, their exercise capacity is limited. Hence, the aim of this work was to investigate the underlying factors that lead to peak and submaximal exercise intolerance of CF-LVAD supported patients.

Methods: Seven months after CF-LVAD implantation, eighty three patients performed a maximal cardiopulmonary exercise test and a six minute walk test. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235684PLOS

Prediction of mortality in very low birth weight neonates in Spain.

PLoS One 2020 9;15(7):e0235794. Epub 2020 Jul 9.

Neonatology Department, Hospital Clínic, BCNatal, Hospital Clínic- Hospital Sant Joan de Déu, Barcelona University, Barcelona, Spain.

Objective: Predictive models for preterm infant mortality have been developed internationally, albeit not valid for all populations. This study aimed to develop and validate different mortality predictive models, using Spanish data, to be applicable to centers with similar morbidity and mortality.

Methods: Infants born alive, admitted to NICU (BW<1500 g or GA<30 w), and registered in the SEN1500 database, were included. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235794PLOS

Clinicopathological Relevance and Prognostic Value of Androgen Receptor in Mammary Paget's Disease with Underlying Invasive Ductal Carcinoma.

Oncol Res Treat 2020 Jul 9:1-7. Epub 2020 Jul 9.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: Mammary Paget's disease (MPD) is a rare cutaneous manifestation. Epidemiologically, more than half of the MPD patients concurrently have underlying invasive ductal carcinoma (MPD-IDC), and their prognosis remains poor despite multimodal treatments of breast cancer have markedly improved patients' survival. Accordingly, it is crucial to seek out novel therapeutic targets of MPD-IDC. Read More

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http://dx.doi.org/10.1159/000507893DOI Listing

An Exploration into Mothers' Experiences of Feeding Children with Autism Spectrum Disorder in South Africa.

Folia Phoniatr Logop 2020 Jul 9:1-10. Epub 2020 Jul 9.

Department of Speech Pathology and Audiology, School of Human and Community Development, University of the Witwatersrand, Johannesburg, South Africa.

Objectives: To explore the experiences of mothers feeding their children with autism spectrum disorder (ASD) in South Africa as well as to better understand the impact of context and culture on feeding disorders.

Participants And Methods: A qualitative research design was employed. Seven mothers of 8 children (1 mother had twins), aged 4-9 years, who were diagnosed with ASD and who had associated feeding difficulties participated in the study. Read More

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http://dx.doi.org/10.1159/000507928DOI Listing

Effects of Vitamin D Supplementation on General and Central Obesity: Results from 20 Randomized Controlled Trials Involving Apparently Healthy Populations.

Ann Nutr Metab 2020 Jul 9:1-12. Epub 2020 Jul 9.

Public Health and Preventive Medicine Teaching and Research Center, Henan University of Chinese Medicine, Zhengzhou, China,

Background: The obesity pandemic has been paralleled by a high prevalence of vitamin D deficiency (VDD). There is growing epidemiological evidence linking low vitamin D status with obesity events. In addition, observational studies also show that obesity may increase the risk of VDD. Read More

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http://dx.doi.org/10.1159/000507418DOI Listing

Heated tobacco product use and associated factors among U.S. youth, 2019.

Authors:
Hongying Dai

Drug Alcohol Depend 2020 Jul 2;214:108150. Epub 2020 Jul 2.

College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address:

Background: In April 2019, the U.S. Food and Drug Administration authorized the marketing of IQOS Heated Tobacco Products (HTPs) in the United States. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108150DOI Listing

The effect of baking conditions on protein digestibility, mineral and oxalate content of wheat breads.

Food Chem 2020 Jul 2;332:127399. Epub 2020 Jul 2.

Food Engineering Department, University of São Paulo, Faculty of Animal Science and Food Engineering (USP/FZEA), Laboratory of Bread and Dough Process (LAPROPAMA), Av., Duque de Caxias Norte 225, 13635-900 Pirassununga, SP, Brazil. Electronic address:

Different baking conditions were used in order to evaluate its effects on bread aspects. Doughs were baked at 160, 190 and 220 °C, during 9, 12, 15 and 20 min, and characterized in relation to color change, oxalate and mineral concentration, and protein digestibility. The higher the baking temperature and time, the higher the crust color change, the lower the oxalate concentration, and the higher the amount of some macro minerals. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127399DOI Listing

The impact of (E/Z)-isomerization and aggregation on the color of rhodoxanthin formulations for food and beverages.

Food Chem 2020 Jun 23;332:127370. Epub 2020 Jun 23.

Geisenheim University, Institute of Beverage Research, Analysis and Technology of Plant-based Foods, Von-Lade-Strasse 1, 65366 Geisenheim, Germany. Electronic address:

Rhodoxanthin is a scarcely explored carotenoid with an extraordinarily large chromophore and high potential to function as red pigment. We report broad ranges of color shades accessible with rhodoxanthin across an unprecedented wide range of (E/Z)-ratios by thermal (E/Z)-isomerization, lyotropic aggregation, and two different formulation techniques, covering shares of the (all-E)-configured isomer of 19-91%. At (E/Z)-ratios of 75 and 23%, rhodoxanthin (E/Z)-isomer mixtures in acetone revealed color hues (CIE-h°) ranging from 20-44° to 36-54°. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127370DOI Listing

Activated prothrombin complex concentrates for direct oral anticoagulant-associated bleeding or urgent surgery: Hemostatic and thrombotic outcomes.

Thromb Res 2020 Jul 1;195:21-28. Epub 2020 Jul 1.

Department of Medicine, University of Ottawa, and the Ottawa Hospital Research Institute, Ottawa, Canada. Electronic address:

Introduction: Studies evaluating the use of activated prothrombin complex concentrates (aPCCs) for DOAC-associated bleeding are sparse.

Materials And Methods: We conducted a retrospective study of patients receiving aPCC for DOAC-associated bleeding or for pre-operative optimization of hemostasis prior to urgent surgery. The primary efficacy outcome was hemostatic efficacy, the primary safety outcome was the 30-day thromboembolic complication rate. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.06.044DOI Listing

Mechanism for sonochemical reduction of Au(III) in aqueous butanol solution under Ar based on the analysis of gaseous and water-soluble products.

Ultrason Sonochem 2020 Jul 1;69:105241. Epub 2020 Jul 1.

Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.

When an aqueous Au(III) solution containing 1-butanol was sonicated under Ar, Au(III) was reduced to Au(0) to form Au particles. This is because various reducing species are formed during sonication, but the reactivity of these species has not yet been evaluated in detail. Therefore, in this study, we analyzed the effects of Au(III) on the rates of the formation of gaseous and water-soluble compounds (CH, CH, CH, CH, CO, CO, H, HO, and aldehydes), and the rate of Au(III) reduction as a function of 1-butanol concentration. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105241DOI Listing

Effect of ultrasound on leaching of lead from landfilled metallurgical residues.

Ultrason Sonochem 2020 Jul 2;69:105239. Epub 2020 Jul 2.

Process Engineering for Sustainable Systems (ProcESS), Department of Chemical Engineering, KU Leuven, Leuven, Belgium. Electronic address:

The potential of ultrasound as a process intensification technique in the extraction of lead from a landfilled metallurgical residues is explored. The silent or non-sonicated process makes use of acidic sodium chloride as the leachate with lead leaching in the range of 45% if a three-stage process is followed. The mixture was sonicated in a batch setup manufactured in-house. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105239DOI Listing

A bioenergetics assessment of aortic regurgitation: A new tool to assess severity?

Authors:
M Poullis

Med Hypotheses 2020 Jun 30;143:110050. Epub 2020 Jun 30.

Department of Cardiac Surgery, Manchester Royal Infirmary, Research carried out at Department of Cardiac Surgery, Manchester Royal Infirmary, Hospital, Manchester, England, United Kingdom. Electronic address:

Aortic regurgitation is frequently classified as mild, moderate or severe based on echocardiography. Patients with mild aortic regurgitation are usually managed medically. Decisions with regard to moderate aortic regurgitation can be difficult. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.110050DOI Listing

Zinc deficiency impairs interferon-γ production on post-transcriptional level.

J Trace Elem Med Biol 2020 Jun 23;62:126598. Epub 2020 Jun 23.

Institute for Occupational, Social and Environmental Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, D-52074 Aachen, Germany. Electronic address:

Background: Zinc is a trace element and is thus commonly known to be indispensable for regular cellular function. Until today, zinc deficiency is a widespread health problem, affecting approximately one sixth of the world's population. Especially the immune system has proven to be highly dependent on zinc. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126598DOI Listing

Surface treatment and electron backscatter diffraction (EBSD) analysis of the body-centered cubic phase in Mg-Li based alloys processed by severe plastic deformation.

Authors:
Takahiro Mineta

Micron 2020 Jun 23;137:102914. Epub 2020 Jun 23.

Department of Mechanical Science and Engineering, Graduate School of Science and Technology, Hirosaki University, Hirosaki 036-8561, Japan. Electronic address:

Although electron backscatter diffraction (EBSD) analysis for Mg-Li based alloys is difficult to conduct, this technique is necessary to understand the properties of these alloys. Numerous studies have addressed the use of electron backscatter diffraction (EBSD) analysis as an effective technique for quantifying Mg-Li based alloys. However, a crystallographic orientation determination of β-Mg by EBSD has not been achieved thus far. Read More

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http://dx.doi.org/10.1016/j.micron.2020.102914DOI Listing

Vaginoscopy for office hysteroscopy: A systematic review & meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 23;252:278-285. Epub 2020 Jun 23.

Birmingham Women's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Mindelsohn Way, Birmingham, B15 2TG, UK.

Objective: To investigate the effect of the vaginoscopic approach to office hysteroscopy on patients' experience of pain, when compared with the traditional approach where a vaginal speculum is used.

Methods: Medline, Embase, CINAHL and the Cochrane library were searched from inception until December 2019, in order to perform a systematic review and meta-analysis of all randomised controlled trials investigating vaginoscopy compared to traditional hysteroscopy on pain experienced by women undergoing diagnostic or operative hysteroscopy in an office setting. Data regarding procedural time, feasibility, incidence of vasovagal reactions and complications, acceptability and satisfaction were also recorded. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.045DOI Listing

Metabolic syndrome components and disease disability in egyptian multiple sclerosis patients.

Mult Scler Relat Disord 2020 Jul 3;44:102336. Epub 2020 Jul 3.

Neurology Department, Faculty of Medicine, Zagazig University; Sharkia, Egypt.

Background: There is limited and inconsistent data on metabolic syndrome (MetS) in multiple sclerosis (MS) patients. The aim of this study was to estimate the frequency of MetS and its components in MS patients and to evaluate their association with disease disability in Egyptian MS patients.

Methods: A cross-section study was carried out on 60 patients (19 males and 41 females) with relapsing remitting MS. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102336DOI Listing

Evaluation of safety, efficacy, tolerability, and treatment-related outcomes of type I interferons for human coronaviruses (HCoVs) infection in clinical practice: An updated critical systematic review and meta-analysis.

Int Immunopharmacol 2020 Jun 25;86:106740. Epub 2020 Jun 25.

Children's Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China; National Clinical Research Center for Child Health and Disorders, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China; Chongqing Key Laboratory of Pediatrics Chongqing, Chongqing, China; Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice.

Materials And Methods: A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science Direct, Wanfang Data, and China National Knowledge Infrastructure (CNKI) until February 2020 was performed. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106740DOI Listing

DL0410 attenuates oxidative stress and neuroinflammation via BDNF/TrkB/ERK/CREB and Nrf2/HO-1 activation.

Int Immunopharmacol 2020 Jul 6;86:106729. Epub 2020 Jul 6.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address:

Oxidative stress and neuroinflammation have been deeply associated with Alzheimer's disease. DL0410 is a novel acetylcholinesterase inhibitor with potential anti-oxidative effects in AD-related animal models, while the specific mechanism has not been fully clarified. In this study, DL0410 was predicted to be related to the modification of cell apoptosis, oxidation-reduction process, inflammatory response and ERK1/ERK2 cascade by in silico target fishing and GO enrichment analysis. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106729DOI Listing

Serum vascular endothelial growth factor as a biomarker for prognosis of minor ischemic stroke.

Clin Neurol Neurosurg 2020 Jul 1;196:106060. Epub 2020 Jul 1.

Department of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin, Hei Longjiang Province, PR China.

Objectives Although vascular endothelial growth factor (VEGF) is a well-known molecule involved with neuronal survival and angiogenesis. there are no prospective studies directed at evaluating a potential association between serum VEGF and minor ischemic stroke. The goal of this study was to investigate the utility of serum VEGF as an index for assessing the 90-day prognosis of minor ischemic stroke patients. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106060DOI Listing

The mutation frequencies of GJB2, GJB3, SLC26A4 and MT-RNR1 of patients with severe to profound sensorineural hearing loss in northwest China.

Int J Pediatr Otorhinolaryngol 2020 May 28;136:110143. Epub 2020 May 28.

Department of Otolaryngology-Head and Neck Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, 730030, PR China; Health Commission of Gansu Province, Lanzhou, Gansu, 730000, PR China. Electronic address:

Objective: To expose the spectrum and frequency of GJB2, GJB3, SLC26A4 and MT-RNR1 in northwest China and to investigate the underlying causative genes in patients without common mutations.

Methods: We analyzed the mutation screening results of GJB2, GJB3, SLC26A4 and MT-RNR1 in 398 unrelated severe-to-profound probands with bilateral, symmetrical sensorineural hearing loss. Subsequently, we selected 10 probands with a significant family history of inherited hearing loss (HL) that did not have the above four common gene mutations to perform next-generation sequencing (NGS) of 139 known deafness genes, followed by co-segregation analysis of all available family members. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110143DOI Listing

Quantitative X-ray fluorescence analysis: Trace level detection of toxic elemental impurities in drug product by ED-XRF spectrometer.

J Pharm Biomed Anal 2020 Jun 23;189:113292. Epub 2020 Jun 23.

Amneal Pharmaceuticals Pvt. Ltd., Ahmedabad, 382213, India.

Inorganic impurity analysis of pharmaceutical drug products is of paramount importance at trace levels due to the availability of toxic metals. The existing techniques require extensive development and chemical treatment to evaluate the presence of class I (Pb, Cd, Hg and As) and class II (Co, V and Ni) heavy metal elements which are harmful to the environment. To overcome these issues, a cost and time effective wavelength dispersive X-ray fluorescence spectrometry (XRF) was introduced to determine the concentration of trace elements in one of the angiotensin receptor blocker (ARB) (tablet sample 300 mg) according to guidelines addressed in ICH Q3D and USP. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113292DOI Listing

GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death.

EBioMedicine 2020 Jul 6;57:102843. Epub 2020 Jul 6.

Lankenau Institute for Medical Research and Lankenau Heart Institute, Wynnewood, PA and Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

Background: Brugada syndrome (BrS) is a rare inherited disease causing sudden cardiac death (SCD). Copy number variants (CNVs) can contribute to disease susceptibility, but their role in Brugada syndrome (BrS) is unknown. We aimed to identify a CNV associated with BrS and elucidated its clinical implications. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102843DOI Listing

Development and validation of the HNC-LL score for predicting the severity of coronavirus disease 2019.

EBioMedicine 2020 Jul 6;57:102880. Epub 2020 Jul 6.

Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Background: Information regarding risk factors associated with severe coronavirus disease (COVID-19) is limited. This study aimed to develop a model for predicting COVID-19 severity.

Methods: Overall, 690 patients with confirmed COVID-19 were recruited between 1 January and 18 March 2020 from hospitals in Honghu and Nanchang; finally, 442 patients were assessed. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102880DOI Listing

Hepatitis B and D in the Pacific Islands of Kiribati.

J Clin Virol 2020 Jun 29;129:104527. Epub 2020 Jun 29.

Ministry of Health and Medical Services and Tungaru Central Hospital, Kiribati.

Background: Historical reports indicate that hepatitis B and hepatitis D are highly endemic in the Pacific Island of Kiribati but current levels are unknown.

Objectives: To determine current prevalence of HBV and HDV in Kiribati, characterize the strains in both mono-infection and co-infection and assess individuals for antiviral therapy.

Study Design: Sera obtained from 219 patients were screened for HBsAg, HBeAg, HBV DNA, anti-HD, and HDV RNA. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104527DOI Listing

Evolution of phytotoxicity during the active phase of co-composting of chicken manure, tobacco powder and mushroom substrate.

Waste Manag 2020 Jul 6;114:25-32. Epub 2020 Jul 6.

Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Science, China Agricultural University, Beijing 100193, China. Electronic address:

This study systematically investigated the phytotoxicity of chicken manure co-composted with tobacco powder and mushroom substrate on seed germination during active phase of composting. All compost products met the sanitation requirements specified in the Chinese national standard; however, only the mushroom substrate compost satisfied the maturity standard. From day 28, the composting entered the end of active phase and the concentrations of K, Zn, Na, Cu and Fe decreased gradually. Read More

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http://dx.doi.org/10.1016/j.wasman.2020.06.034DOI Listing

The use of green spectroscopy with multivariate calibration models for simultaneous analysis of ternary drug mixture in combined oral antidiabetic pill.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 23;241:118638. Epub 2020 Jun 23.

Pharmaceutical Analysis Department, Faculty of Pharmacy, Menoufia University, Egypt. Electronic address:

In this work, different chemometric calibration models were developed and validated for the purpose of determining of ternary mixture of oral antidiabetic drugs; vildagliptin (VDG), saxagliptin (SAX) and sitagliptin phosphate (STG). The used models were Partial least squares (PLS) and Artificial Neural Networks (ANN). However, on these various models the impact of genetic algorithm (GA) as a form of variable selection was also investigated. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118638DOI Listing

Colorimetric detection of cholesterol based on peroxidase mimetic activity of GoldMag nanocomposites.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 1;241:118675. Epub 2020 Jul 1.

College of Food Engineering, Harbin University of Commerce, Harbin 150076, People's Republic of China.

Herein, Gold and magnetic particles (GoldMag), an enzyme mimetic of horseradish peroxidase (HRP), have been designed to construct a colorimetric sensor for cholesterol (Cho). The well-dispersed GoldMag was successfully prepared by green reduction using a self-assembly method based on the surface amino groups, and characterized by Fourier transform infrared (FTIR), X-Ray Photoelectron Spectroscopic (XPS) techniques. In the presence of HO, the resulting nanocomposites possessed enhanced intrinsic peroxidase-like activity and could catalytically oxidize 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) to produce a green colored product, which could be observed apparently by the naked eye. Read More

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