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An Pediatr (Engl Ed) 2021 Jun 20. Epub 2021 Jun 20.

Centro de Salud «Torre Ramona», Zaragoza, Spain.

An Pediatr (Barc) 2021 Jun 19. Epub 2021 Jun 19.

Servicio de Alergia e Inmunología Clínica. Institut de Recerca Pediàtrica, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España. Electronic address:

An Pediatr (Engl Ed) 2021 Jun 18. Epub 2021 Jun 18.

Servicio de Alergia e Inmunología Clínica, Institut de Recerca Pediàtrica, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain. Electronic address:

An Pediatr (Engl Ed) 2021 Jun 18. Epub 2021 Jun 18.

Unidad de Infectología Pediátrica-UGC Pediatría, Hospital Regional Universitario de Málaga, Málaga, Spain.

Introduction: HIV infection was the main risk of suffering Pneumocystis jirovecii pneumonia (PJP). The clinical-epidemiological characteristics of PJP have currently changed, with there being few studies on this.

Methods: A retrospective observational study was carried out on paediatric patients diagnosed with PJP over a 17 year period in a third level hospital in Spain. Read More

An Pediatr (Barc) 2021 Jun 18. Epub 2021 Jun 18.

Sección de Urología Funcional, Reconstructiva e Incontinencia Urinaria, Hospital Clínico Universitario de Valencia; Facultad de Medicina, Universidad de Valencia, Valencia, España.

An Pediatr (Barc) 2021 Jun 18. Epub 2021 Jun 18.

Cirugía Pediátrica, Complejo Hospitalario de Navarra, Pamplona, España.

An Pediatr (Barc) 2021 Jun 16. Epub 2021 Jun 16.

Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón de Madrid, Instituto de Investigación sanitaria del Hospital Gregorio Marañón, Madrid, España.

An Pediatr (Barc) 2021 Jun 17. Epub 2021 Jun 17.

Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón de Madrid, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón; Grupo Español de Reanimación Cardiopulmonar Pediátrica y Neonatal. Red de Salud Materno-Infantil (SAMID II). RETICS financiada por el PN I+D+i 2013-2016, ISCIII- Subdirección General de Evaluación y Fomento de la Investigación y el Fondo Europeo de Desarrollo Regional (FEDER) Ref: RD16/0022/0007. Grupo Español de Reanimación Cardiopulmonar Pediátrica y Neonatal.

Objectives: To analyse the 2020 international and European recommendations for paediatric cardiopulmonary resuscitation (CPR), highlight the most important changes and propose lines of development in Spain.

Methods: Critical analysis of the paediatric cardiopulmonary resuscitation recommendations of the European Resuscitation Council.

Results: The most relevant changes in the CPR recommendations for 2020 are in basic CPR the possibility of activating the emergency system after performing the five rescue ventilations with the mobile phone on loudspeaker, and in advanced CPR, bag ventilation between two rescuers if possible, the administration of epinephrine as soon as a vascular access is obtained, the increase in the respiratory rate in intubated children between 10 and 25bpm according to their age and the importance of controlling the quality and coordination of CPR. Read More

An Pediatr (Barc) 2021 Jun 17. Epub 2021 Jun 17.

Unidad de Cuidados Intensivos Pediátricos, UGC Cuidados Críticos y Urgencias Pediátricas, Hospital Regional Universitario de Málaga, Málaga, España.

An Pediatr (Barc) 2021 Jun 15. Epub 2021 Jun 15.

Servicio de Pediatría, Hospital San Pedro de Alcántara, Cáceres, España.

An Pediatr (Engl Ed) 2021 Jun 14. Epub 2021 Jun 14.

Unidad de Neumología Pediátrica, Hospital Universitario Miguel Servet, Zaragoza, Spain.

Introduction: Neonatal cystic fibrosis (CF) screening has enabled the disease to be diagnosed early, and is a determining factor in the increase in survival of these patients. Its main disadvantage is its low specificity and elevated number of false positives. The aim of this study is to analyse the differences in immunoreactive trypsin (IRT) between the different groups of newborns (NB) with a positive neonatal screen depending on whether they were healthy, healthy carriers, affected by CF, or CFSPID (Cystic Fibrosis Screen Positive, Inconclusive Diagnosis). Read More

An Pediatr (Barc) 2021 Jun 14. Epub 2021 Jun 14.

Sección de Gastroenterología y Nutrición, Hospital Infantil Universitario Niño Jesús, Madrid, España.

Aim: Ketogenic dietary therapies (KDT) produce anticonvulsant and neuroprotective effects, reduce seizures and improve the cognitive state in patients with epilepsy. Our purpose was to evaluate the effects of KDT in children with refractory epilepsy (effectiveness, side effects, impact on nutritional status and growth).

Methods: A retrospective and prospective observational descriptive study was conducted in a Spanish tertiary hospital (January 2000 to December 2018). Read More

An Pediatr (Barc) 2021 Jun 11. Epub 2021 Jun 11.

Servicio de Pediatría, Hospital Infantil Universitario Niño Jesús, Madrid, España.

Introduction: In the treatment of patients with acute bronchiolitis there is great variability in clinical practice. Treatments whose efficacy has not been demonstrated are frequently used despite the recommendations contained in the Clinical Practice Guidelines.

Material And Methods: A quality improvement strategy is implemented in the care of patients with acute bronchiolitis in the Emergency Department, which is maintained for five years and is periodically updated to be increasingly restrictive regarding the use of bronchodilators. Read More

An Pediatr (Barc) 2021 Jun 11. Epub 2021 Jun 11.

Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Miguel Servet, Zaragoza, España.

An Pediatr (Barc) 2021 May 14. Epub 2021 May 14.

Centro de Salud Valdefierro, Zaragoza, España; Departamento de Pediatría, Universidad de Zaragoza, Zaragoza, España.

An Pediatr (Barc) 2021 Jun 10. Epub 2021 Jun 10.

Servicio de Pediatría, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, España. Electronic address:

Introduction: Congenital hypogonadotropic hypogonadism (CHH) can present alone or in association with anosmia or other congenital malformations. More than 30 genes have been identified as being involved in the pathogenesis of CHH with different patterns of inheritance, and the increasing availability of next generation sequencing (NGS) has increased the diagnostic yield.

Methods: We analysed the diagnostic yield of NGS in patients with CHH using the clinical exome filtered with virtual panels. Read More

An Pediatr (Engl Ed) 2021 Jun 9. Epub 2021 Jun 9.

Equipo de Investigación PRECAM, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain; Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Oviedo, Spain; Área Sanitaria 3, Servicio de Salud del Principado de Asturias, Avilés, Spain.

Introduction: Diet and physical activity are factors that have key roles in childhood overweight and obesity prevention. Appropriate assessment of these factors is an essential task in public health.

Objective: The main aims of the study are to assess body composition, physical activity, and adherence to Mediterranean diet of soccer players, aged 13 to 16 years old in Asturias, Spain. Read More

An Pediatr (Barc) 2021 Jun 9. Epub 2021 Jun 9.

Servicio de Alergia e Inmunología Clínica Pediátrica, Hospital Sant Joan de Déu, Barcelona, España; Institut de Recerca Sant Joan de Déu, Barcelona, España; Universitat de Barcelona, Barcelona, España.

In the last decades, allergic diseases have increased exponentially and although pediatric asthma prevalence is stabilizing, in Spain is estimated around 10%. Not the same with food allergy and anaphylaxis which are clearly increasing, becoming a public health problem of the first magnitude. Considering epidemiological trends, the European Academy of Allergy and Clinical Immunology (EAACI) estimates that in less than 15 years more than half of European population will suffer from some type of allergy. Read More

An Pediatr (Barc) 2021 Jun 8. Epub 2021 Jun 8.

Hospital Materno Infantil, Badajoz, España.

An Pediatr (Barc) 2021 Jun 8. Epub 2021 Jun 8.

Servicio de Pediatría, Hospital Universitario Virgen Macarena, Sevilla, España.

An Pediatr (Engl Ed) 2021 Jun 5. Epub 2021 Jun 5.

Área de Pediatría, Sección de Pediatría Crítica, Cuidados Intermedios y Paliativos Pediátricos, Hospital Clínico Universitario de Santiago, Santiago de Compostela, La Coruña, Spain; Grupos de Investigación Soporte Vital y Simulación (Instituto de Investigación de Santiago) y CLINURSID (Universidad de Santiago), A Coruña, Spain; Grupo de trabajo de Ética de Sociedad Española de Cuidados Intensivos Pediátricos, Spain.

An Pediatr (Barc) 2021 Jun 3. Epub 2021 Jun 3.

Complejo Asistencial de Zamora, Zamora, Spain.

We present the summary of a critical appraisal document of the available evidence on COVID-19, developed with a clinical practice guide format following GRADE methodology. The document tries to provide answers to a series of structured clinical questions, with an explicit definition of the population, intervention / exposure, comparison and outcome, and a rating of the clinical relevance of the outcome measures. We conducted a systematic review of the literature to answer the questions, grouped into six chapters: epidemiology, clinical practice, diagnosis, treatment, prevention, and vaccination. Read More

An Pediatr (Barc) 2021 Jun 1. Epub 2021 Jun 1.

Hospital Universitario La Paz, Madrid, SPAIN.

An Pediatr (Barc) 2021 Jun 1. Epub 2021 Jun 1.

Servicio de Pediatría, Hospital Virgen de los Lirios, Alcoy, Alicante, Spain.

An Pediatr (Barc) 2021 Jun 1. Epub 2021 Jun 1.

Hospital Universitario Central de Asturias. C/Avenida de Roma S/N, 33011, Oviedo, Asturias, Spain.

An Pediatr (Engl Ed) 2021 Jun 3. Epub 2021 Jun 3.

Sección de Gastroenterología y Nutrición Pediátrica, Hospital Clínico Universitario de Valencia, Valencia, Spain; Departamento de Pediatría, Obstetricia y Ginecología, Universidad de Valencia, Valencia, Spain.

Introduction: Chronic abdominal pain (CAP) in children is a symptom that frequently leads to a visit to the paediatrician, which affects family life and occasionally requires the need to perform diagnostic studies (DS). The objective was to carry out a qualitative, quantitative, and economic analysis on the tests requested.

Material And Methods: An observational, prospective and multicentre study was conducted that included children between 4-15 years old affected by CAP. Read More

An Pediatr (Engl Ed) 2021 Jun 3. Epub 2021 Jun 3.

Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Madrid, Spain; Red de Salud Maternoinfantil y del Desarrollo (RedSAMID), RETICS financiada por el Instituto de Salud Carlos III (ISCIII), Spain.

An Pediatr (Barc) 2021 Jun 3. Epub 2021 Jun 3.

Servicio de Otorrinolaringología, Hospital Universitario Miguel Servet, Zaragoza, España.

An Pediatr (Barc) 2021 Jun 3. Epub 2021 Jun 3.

Unidad de Neuropediatría, Servicio de Pediatría, Hospital Infantil Universitario Miguel Servet, Zaragoza, España.

An Pediatr (Engl Ed) 2020 Oct 10;93(4):267.e1-267.e9. Epub 2020 Oct 10.

CIBER de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain; Departamento de Genética y Genómica, Instituto de Investigación Sanitaria, Hospital Universitario Fundación Jiménez Díaz, IIS-UAM, Universidad Autónoma de Madrid, Madrid, Spain.

The development of medicines for certain rare diseases can be cut short by lack of funding. In certain cases the patients themselves, or their relatives, occasionally fund the clinical trial in which they will be treated with the investigational medicine. There are three models of self-funded clinical research: two of them, 'pay to try' and 'pay to participate', have already been put into practice. Read More