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Int J Environ Res Public Health 2022 Jun 17;19(12). Epub 2022 Jun 17.

Division of Colorectal Surgery, Department of Surgery, Severance Hospital, College of Medicine, Yonsei University, Seoul 03722, Korea.

Purpose: The purpose of our study was to evaluate the relationship between benign anal inflammatory diseases and anorectal cancer and assess its risk factors.

Methods: A retrospective matched cohort study was conducted that included data from 2002 to 2013. The National Health Insurance Service National Sample Cohort data from 2002 to 2013 was used for the study. Read More

Lasers Med Sci 2022 May 23. Epub 2022 May 23.

General Surgery Department, Colorectal Surgery Unit, Mansoura University Hospitals, Mansoura University, 60 El-Gomhoria Street, Mansoura, 35516, Dakahlia, Egypt.

Surgery for benign anal conditions is a common practice and is usually followed by a good outcome. The present review aimed to summarize the emergence and evolution of different laser techniques used for the treatment of benign anal conditions and report their current outcome. PubMed and Scopus were searched for studies that assessed the use of laser in benign anal conditions. Read More

Int J Surg 2022 Jun 11;102:106661. Epub 2022 May 11.

Colorectal Research Center, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Background: Anal fissure is a linear tear in the distal anoderm most frequently occurring in the posterior midline. Lateral internal sphincterotomy is considered the gold standard for the treatment of this condition. To this date, several pharmacological and neuromodulatory therapies have been tried out as alternative non-invasive treatments for anal fissures, however, the efficacy of some of these methods remains to be understood. Read More

Tech Coloproctol 2022 Jul 5;26(7):571-582. Epub 2022 May 5.

Department of Surgery, Proctos Clinic, Bilthoven, The Netherlands.

Background: A chronic anal fissure is a common, painful condition with great impact on daily life. The exact pathogenesis has not been fully elucidated and treatment varies. A large percentage of patients experience pelvic floor dysfunction (dyssynergia and increased pelvic floor muscle tone). Read More

J Exp Pharmacol 2022 27;14:149-165. Epub 2022 Apr 27.

Research and Development Center, Himalaya Wellness Company, Bengaluru, Karnataka, India.

Background: Although ulcerative proctitis (UP) and anal fissure (AF) are common anorectal diseases, there are no appropriate experimental models to screen the drugs intended for these conditions. In this context, existing experimental models mimicking these diseases were modified and the polyherbal formulation, HPLF-111624 was evaluated in these models.

Objective: To establish animal model for UP and AF and to evaluate polyherbal formulation, HPLF-111624 in these disease models. Read More

Medicina (Kaunas) 2022 Mar 1;58(3). Epub 2022 Mar 1.

Faculty of Medicine, Gazi University, Cankaya, Ankara 06560, Turkey.

Anal stenosis, which develops as a result of aggressive excisional hemorrhoidectomy, especially with the stoutly use of advanced technologies (LigaSure, ultrasonic dissector, laser, etc.), has become common, causing significant deterioration in the patient's quality of life. Although non-surgical treatment is effective for mild anal stenosis, surgical reconstruction is unavoidable for moderate to severe anal stenosis that causes distressing, severe anal pain, and inability to defecate. Read More

Altern Ther Health Med 2022 Mar 24. Epub 2022 Mar 24.

Context: The onset of the COVID-19 pandemic has resulted in an increasingly sedentary lifestyle among people working from home (WFH), including 71% of Information and Technology (IT) workers. The lifestyle lacks physical activity and also affects people emotionally, which can lead to serious ailments.

Objective: The study aimed to identify and understand the burden from gastrointestinal complaints on individuals in the IT sector, who have been working from home due to the COVID-19 pandemic and lockdown. Read More

J Cataract Refract Surg 2022 Apr;48(4):508-512

Salt Lake City, Utah.

A 40-year-old woman was referred for the assessment of bilateral corneal opacities with gradual visual decline over the course of the past decade. Her past ocular history is significant for bilateral amblyopia and strabismus surgery in both eyes before age 5. The patient's parents were told by her childhood ophthalmologist that she had a hereditary disorder. Read More

J Korean Med Sci 2022 Mar 7;37(9):e72. Epub 2022 Mar 7.

Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.

Background: Colorectal polyps are the most common cause of isolated hematochezia in children, which requires a colonoscopy for diagnosis. We aimed to investigate the potential utility of fecal calprotectin (FC) in assessing colorectal polyps detected by colonoscopy among children presenting with isolated hematochezia.

Methods: Pediatric patients of the age of < 18 years who had undergone both colonoscopy and FC tests for isolated hematochezia from June 2016 to May 2020 were included in the present multicenter, retrospective, cross-sectional study. Read More

Int J Colorectal Dis 2022 Apr 22;37(4):973-978. Epub 2022 Feb 22.

Department of Surgery, Proctos Clinic, Bilthoven, The Netherlands.

Background: Chronic anal fissure (CAF) is a common, bothersome condition frequently accompanied by pelvic floor complaints. Despite current guidelines, optimal management is challenging. The aim of this study is to evaluate current management of CAF among gastrointestinal surgeons in the Netherlands. Read More

Dis Colon Rectum 2022 05;65(5):e339

Chief Colorectal Surgeon, Indus International Hospital, Mohali, Punjab, India.

Am J Transl Res 2022 15;14(1):432-439. Epub 2022 Jan 15.

Department of Anorectal Surgery, Jinan City People's Hospital Jinan 271199, Shangdong, China.

Background: To explore the efficacy of posterior median anal incision plus incision and drainage of anal sinus on chronic anal fissure (CAF), and its influence on incidence and recurrence of postoperative infection.

Methods: Altogether 130 patients with CAF treated during January 2017 and January 2021 were included and divided into a research group (RG) and control group (CG). Among them, 80 patients in the RG were treated with posterior median anal incision and expansion plus anal sinus incision and drainage, while 50 in the CG were treated with lateral internal sphincterotomy. Read More

Front Surg 2021 26;8:798405. Epub 2022 Jan 26.

Medical Statistic, Department of Life, Health and Environmental Science, University of L'Aquila, L'Aquila, Italy.

Introduction: The coronavirus disease 2019 (COVID-19) pandemic has shown a very critical impact on surgical procedures all over the world. Italy faced the deepest impact from the beginning of March 2020. Elective operations, screening, and follow-up visits had been suspended giving priority to urgent and oncologic surgery. Read More

Int J Colorectal Dis 2022 Mar 11;37(3):693-700. Epub 2022 Feb 11.

Unità Operativa Di Chirurgia Generale E Oncologica, Azienda Ospedaliera San Giuseppe Moscati, Avellino, Italy.

Purpose: Anal fissure is caused by a pathological contraction of the internal anal sphincter. Lateral internal sphincterotomy remains the gold standard for the treatment of fissure. Botulinum toxin injections have been proposed to treat this condition without any risk of permanent injury of the internal sphincter. Read More

Wiad Lek 2021 ;74(12):3160-3167

UNIVERSITY OF KUFA, KUFA, IRAQ.

Objective: The aim: Recognizing gastrointestinal symptoms that precede COVID-19 respiratory difficulties may be crucial for effective early detection and treatment.

Patients And Methods: Materials and methods: A total of 200 individuals with the post-covid-19 symptoms for both genders in clinical private and hospital COVID-19 verified by polymerase chain reaction were tracked until they recovered. To evaluate the duration of symptoms as a predictor of COVID-19 prognosis, we proposed a link between gastrointestinal symptoms, metabolic disturbances and disease severity. Read More

Ann Coloproctol 2022 Jan 18. Epub 2022 Jan 18.

Department of General Surgery, Pendik Medipol University School of Medicine, Istanbul, Turkey.

Purpose: Acute anal fissure, a disease characterized by severe pain in the anorectal area, reduces quality of life and becomes chronic absent appropriate treatment. More recently, anaerobic infections have been noted as contributive to etiopathogenesis. This study investigates topical metronidazole's effect in the treatment of acute anal fissure. Read More

Front Surg 2021 28;8:799607. Epub 2021 Dec 28.

SOSD Proctologia, USL Toscana Centro, Florence, Italy.

Surgery for chronic anal fissure is challenging for every proctologist. Solving the pain by guaranteeing rapid and effective healing is the objective, but what is the price to pay today in functional terms? Though this result is nowadays partially achievable through interventions that include the execution of an internal sphincterotomy among the procedures, it is necessary to underline the high rate of patients who can present faecal incontinence. The aim of this study is to explore the effectiveness of scanner-assisted CO laser fissurectomy. Read More

BMJ 2022 01 12;376:e066834. Epub 2022 Jan 12.

Royal Derby Hospital, Derby DE22 3NE, UK; University of Nottingham, Nottingham NG7 2RD, UK.

Contact Dermatitis 2022 05 22;86(5):427-429. Epub 2022 Jan 22.

Dermatology Consultant, Department of Dermatology, Sulis Hospital, Bath, UK.

Surgery 2022 Jul 5;172(1):41-52. Epub 2022 Jan 5.

Department of Surgery, South Auckland Clinical Campus, The University of Auckland, Middlemore Hospital, Auckland, New Zealand.

Background: There are multiple treatments for anal fissures. These range from medical treatment to surgical procedures, such as sphincterotomy. The aim of this study was to compare the relative clinical outcomes and effectiveness of interventional treatments for anal fissure. Read More

Ann Ital Chir 2021 ;92:554-559

Introduction: The role of augmented internal anal sphincter (IAS) tone in the genesis of chronic anal fissure (CAF) is still unclear. Lateral internal sphincterotomy (LIS) is the most employed surgical procedure, aiming to reduce the IAS tone leaving a permanent anatomical alteration and it is burdened by high risk post-operative anal incontinence (AI). The aim of this work was to evaluate if the pre-operative manometric alterations of CAFs with hypertonic IAS would normalize after sphincter preserving surgical procedure. Read More

Healthcare (Basel) 2021 Dec 10;9(12). Epub 2021 Dec 10.

Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, 39008 Santander, Spain.

Introduction: Oxygen is emerging as an important factor in the local regulation of bone remodeling. Some preclinical data suggest that hyperoxia may have deleterious effects on bone cells. However, its clinical relevance is unclear. Read More

Exp Ther Med 2022 Jan 25;23(1):86. Epub 2021 Nov 25.

Laboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, Maharashtra 411007, India.

Hemorrhoids, anal fistula and fissure are common anorectal complications. Anorectal diseases are associated with severe pain, inflammation, swelling, itching and bleeding. These diseases may be managed with different medical treatments or surgical procedures, depending on their severity. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Dec;24(12):1041-1047

Anal fissure is a common anorectal disease, with anal pain as the main manifestation. Severe anal pain can affect the quality of life of patients. In clinical practice, there are some controversies about the treatment of anal fissure, especially the surgical indications. Read More

Georgian Med News 2021 Nov(320):7-13

2Department of Surgery «Yaroslavl State Medical University», Faculty of Post-Diploma Professional Education and Education of Personnel of Highest Qualification, Ministry of Health of the Russian Federation, Yaroslavl, Russian Federation.

Objective - to compare the concentrations of inflammatory markers interleukin-6, CRP, and lactoferrin in the serum of patients with benign diseases of the rectum, depending on the volume of surgical intervention and evaluate their changes in different periods after surgery. Been surveyed 92 patients: 54 patients (control group) were operated on for one of the three diseases - chronic hemorrhoids, fistula rectum and chronic anal fissure, 38 patients (main group) operated simultaneously over two or more diseases (combined pathology), where the main were diagnosed with the above diseases. In both groups of patients was determined concentration of interleukin-6, CRP and lactoferrin in serum before surgery, on 3 and 7 days after surgery. Read More

Surgery 2022 03 6;171(3):615-620. Epub 2021 Dec 6.

Division of Colon and Rectal Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI. Electronic address:

Background: Current American Society of Colorectal Surgery Clinical Practice Guidelines for Ambulatory Anorectal Surgery endorse use of monitored anesthesia care, general anesthesia, or spinal anesthesia based on physician and patient preference. Although several studies support the use of monitored anesthesia care over general anesthesia, the literature regarding spinal anesthesia is limited and heterogenous due to small sample sizes and disparate spinal anesthesia techniques. Saddle block anesthesia is a form of spinal anesthesia that localizes to the lowermost sacral spinal segments allowing for preservation of lower extremity motor function and faster recovery. Read More

World J Clin Cases 2021 Nov;9(32):9722-9730

Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo 90100, Sicily, Italy.

Background: Lateral internal sphincterotomy is still the approach of choice for the treatment of chronic anal fissure (CAF) with internal anal sphincter (IAS) hypertonia, but it is burdened by high-risk postoperative faecal incontinence (FI). Sphincter saving procedures have recently been reconsidered as treatments to overcome this risk. The most employed procedure is fissurectomy with anoplasty, eventually associated with pharmacological sphincterotomy. Read More

Ann Coloproctol 2021 Dec 3. Epub 2021 Dec 3.

Division of General Surgery, Department of Surgery, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.

Purpose: Our aim was to evaluate the effectiveness of combining a fissurectomy with a botulinum toxin A injection in treating chronic anal fissure.

Methods: A single surgeon in Saudi Arabia conducted a nonrandomized prospective cohort study between October 2015 and July 2020. The cohort included 116 female patients with chronic anal fissures with a mean age of 36. Read More

Contemp Clin Trials Commun 2021 Dec 16;24:100874. Epub 2021 Nov 16.

Proctos Clinic, Department of Surgery, Bilthoven, the Netherlands.

Background: Chronic anal fissure (CAF) is a common cause of severe anorectal pain with a high incidence rate. Currently, a wide range of treatment options are available with recurrence rates varying between 7 and 42%. Pelvic floor physical therapy (PFPT) is a treatment option for increased pelvic floor muscle tone and dyssynergia which often accompanies CAF. Read More

Updates Surg 2022 Feb 27;74(1):179-183. Epub 2021 Nov 27.

General Surgery, Hospital Val Vibrata, Sant'omero, 64027, L'Aquila, TE, Italy.

We report the results of the surgical treatment of anal fissures complicated by abscess or fistula and formulate hypotheses about their nature. Among patients operated between 2012 and 2020 for anal fissure resistant to medical therapy, those affected by septic complications were selected for our inquiry. Surgical treatment consisted in the drainage of the sepsis, fissurectomy, posterior sphincterotomy and anoplasty. Read More