145 results match your criteria Anais da Academia Brasileira de Ciencias[Journal]


Clinical Proteomics in Colorectal Cancer, a Promising Tool for Improving Personalised Medicine.

Proteomes 2018 Dec 2;6(4). Epub 2018 Dec 2.

Department of Anatomy and Cell Biology, Université de Sherbrooke, 3201 Jean-Mignault, Sherbrooke, QC J1E 4K8, Canada.

Colorectal cancer is the third most common and the fourth most lethal cancer worldwide. In most of cases, patients are diagnosed at an advanced or even metastatic stage, thus explaining the high mortality. The lack of proper clinical tests and the complicated procedures currently used for detecting this cancer, as well as for predicting the response to treatment and the outcome of a patient's resistance in guiding clinical practice, are key elements driving the search for biomarkers. Read More

View Article
December 2018

Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta.

Int J Mol Sci 2018 Nov 27;19(12). Epub 2018 Nov 27.

National Institute for Health and Medical Research, UMR-S 1139, Faculté de Pharmacie de Paris, Université Paris Descartes, Sorbonne Paris Cité, F-75006 Paris, France.

The human placenta is an organ between the blood of the mother and the fetus, which is essential for fetal development. It also plays a role as a selective barrier against environmental pollutants that may bypass epithelial barriers and reach the placenta, with implications for the outcome of pregnancy. The aryl hydrocarbon receptor (AhR) is one of the most important environmental-sensor transcription factors and mediates the metabolism of a wide variety of xenobiotics. Read More

View Article
November 2018
2 Reads

The Role of the Anti-Aging Protein Klotho in IGF-1 Signaling and Reticular Calcium Leak: Impact on the Chemosensitivity of Dedifferentiated Liposarcomas.

Cancers (Basel) 2018 Nov 14;10(11). Epub 2018 Nov 14.

INSERM U1218, F-33076 Bordeaux, France.

By inhibiting Insulin-Like Growth Factor-1-Receptor (IGF-1R) signaling, Klotho (KL) acts like an aging- and tumor-suppressor. We investigated whether impacts the aggressiveness of liposarcomas, in which IGF-1R signaling is frequently upregulated. Indeed, we observed that a higher expression in liposarcomas is associated with a better outcome for patients. Read More

View Article
November 2018
4 Reads

Lipid Identification and Transcriptional Analysis of Controlling Enzymes in Bovine Ovarian Follicle.

Int J Mol Sci 2018 Oct 20;19(10). Epub 2018 Oct 20.

UMR PRC, INRA 85, CNRS 7247, Université de Tours, IFCE, 37380 Nouzilly, France.

Ovarian follicle provides a favorable environment for enclosed oocytes, which acquire their competence in supporting embryo development in tight communications with somatic follicular cells and follicular fluid (FF). Although steroidogenesis in theca (TH) and granulosa cells (GC) is largely studied, and the molecular mechanisms of fatty acid (FA) metabolism in cumulus cells (CC) and oocytes are emerging, little data is available regarding lipid metabolism regulation within ovarian follicles. In this study, we investigated lipid composition and the transcriptional regulation of FA metabolism in 3⁻8 mm ovarian follicles in bovine. Read More

View Article
October 2018
6 Reads

A density assignment method for dose monitoring in head-and-neck radiotherapy.

Strahlenther Onkol 2018 Oct 9. Epub 2018 Oct 9.

Univ Rennes, CLCC Eugène Marquis, INSERM, LTSI - UMR 1099, F-35000, Rennes, France.

Background And Purpose: During head-and-neck (H&N) radiotherapy, the parotid glands (PGs) may be overdosed; thus, a tool is required to monitor the delivered dose. This study aimed to assess the dose accuracy of a patient-specific density assignment method (DAM) for dose calculation to monitor the dose to PGs during treatment.

Patients And Methods: Forty patients with H&N cancer received an intensity modulated radiation therapy (IMRT), among whom 15 had weekly CTs. Read More

View Article
October 2018
1 Read

Postoperative ileus concealing intra-abdominal complications in enhanced recovery programs-a retrospective analysis of the GRACE database.

Int J Colorectal Dis 2018 Oct 6. Epub 2018 Oct 6.

Department of Visceral Surgery, CHU Clermont-Ferrand, 63003, Clermont Ferrand, France.

Purpose: Postoperative ileus (POI) occurrence within enhanced recovery programs (ERPs) has decreased. Also, intra-abdominal complications (IAC) such as anastomotic leakage (AL) generally present late. The aim was to characterize the link between POI and the other complications occurring after surgery. Read More

View Article
October 2018
4 Reads

Cell Cycle Changes after Glioblastoma Stem Cell Irradiation: The Major Role of RAD51.

Int J Mol Sci 2018 Oct 3;19(10). Epub 2018 Oct 3.

Laboratoire de Neurosciences Expérimentales et Cliniques (LNEC), Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1084, Université de Poitiers, F-86073 Poitiers, France.

"Glioma Stem Cells" (GSCs) are known to play a role in glioblastoma (GBM) recurrence. Homologous recombination (HR) defects and cell cycle checkpoint abnormalities can contribute concurrently to the radioresistance of GSCs. DNA repair protein RAD51 homolog 1 (RAD51) is a crucial protein for HR and its inhibition has been shown to sensitize GSCs to irradiation. Read More

View Article
October 2018
2 Reads

Correction to: The Efficacy of Using Peer Mentors to Improve Maternal and Infant Health Outcomes in Hispanic Families: Findings from a Randomized Clinical Trial.

Matern Child Health J 2018 10;22(Suppl 1):124

Catholic Charities of Tennessee, Inc., Nashville, TN, USA.

The article "The Efficacy of Using Peer Mentors to Improve Maternal and Infant Health Outcomes in Hispanic Families: Findings from a Randomized Clinical Trial", written by Melanie Lutenbacher, Tonya Elkins, Mary S. Dietrich and Anais Riggs, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 31 May 2018 without open access. With the author(s)' decision to opt for Open Choice the copyright of the article changed on 16 July 2018 to Read More

View Article
October 2018
1 Read

Evaluation of the Bruker® MBT Sepsityper IVD module for the identification of polymicrobial blood cultures with MALDI-TOF MS.

Eur J Clin Microbiol Infect Dis 2018 Nov 20;37(11):2145-2152. Epub 2018 Aug 20.

Department of Microbiology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, B-1200, Brussels, Belgium.

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) considerably reduces timeframe required from initial blood culture positivity towards complete bacterial identification. However, rapid identification of polymicrobial blood cultures remains challenging. We evaluated the performances of the Bruker® MBT Sepsityper IVD module on MALDI-TOF MS for the direct identification of polymicrobial blood culture bottles. Read More

View Article
November 2018
1 Read

Multiple Ways to Detect IDH2 Mutations in Angioimmunoblastic T-Cell Lymphoma from Immunohistochemistry to Next-Generation Sequencing.

J Mol Diagn 2018 Sep 5;20(5):677-685. Epub 2018 Jul 5.

INSERM U955 Équipe 9, Institut Mondor de Recherche Biomédicale, Créteil, France; Université Paris Est, Créteil, France; Département de Pathologie, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil, France.

Angioimmunoblastic T-cell lymphoma (AITL) is a peripheral T-cell lymphoma associated with chemoresistance and a poor prognosis. Various nonsynonymous mutations in the R172 residue of IDH2 are present in 20% to 30% of AITL patients. In addition to their diagnostic value, these mutations are potentially targetable, especially by isocitrate dehydrogenase (IDH) 2 inhibitor, and therefore their identification in a routine setting is clinically relevant. Read More

View Article
September 2018
3 Reads

Gene flow and adaptive potential in a generalist ectoparasite.

BMC Evol Biol 2018 06 19;18(1):99. Epub 2018 Jun 19.

Maladies Infectieuses & Vecteurs: Ecologie, Génétique, Evolution & Contrôle (MIVEGEC), Université de Montpellier - CNRS - IRD, Centre IRD, 911 avenue, Agropolis, BP 64501, F-34000, Montpellier, France.

Background: In host-parasite systems, relative dispersal rates condition genetic novelty within populations and thus their adaptive potential. Knowledge of host and parasite dispersal rates can therefore help us to understand current interaction patterns in wild populations and why these patterns shift over time and space. For generalist parasites however, estimates of dispersal rates depend on both host range and the considered spatial scale. Read More

View Article
June 2018
16 Reads

Historical Perspective of Arboviruses in Mozambique and Its Implication for Current and Future Epidemics.

Adv Exp Med Biol 2018;1062:11-18

Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.

Mozambique is a tropical country situated in the Southern part of Africa, a region where data on the burden and epidemiology of arbovirus is presently quite scarce although the frequency of outbreaks caused by arboviruses is rapidly increasing. Outbreaks of dengue fever have been reported in Mozambique, Angola and Tanzania and a recent unprecedented outbreak of Yellow fever has been recorded in Angola. These new outbreaks collectively suggest that arboviruses, and specifically flavivirus infections, are endemic in Mozambique. Read More

View Article
November 2018
12 Reads

[Sclerodermatous changes revealing porphyria cutanea tarda].

Authors:
A Brunet E Hainaut

Ann Dermatol Venereol 2018 Aug - Sep;145(8-9):500-504. Epub 2018 May 24.

Service de dermatologie, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.

Background: Porphyria cutanea tarda (PCT) is associated with cutaneous accumulation of porphyrins. This accumulation results from a deficiency of uroporphyrinogen decarboxylase occurring only in the liver. The classical presentation is blistering on sun-exposed areas. Read More

View Article
May 2018
13 Reads

Is 3-Carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) a Clinically Relevant Uremic Toxin in Haemodialysis Patients?

Toxins (Basel) 2018 May 18;10(5). Epub 2018 May 18.

Department of Nephrology, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, F-69495 Pierre-Benite, France.

3-Carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) is a metabolite of furan fatty acid and a marker of fish oil intake. CMPF is described as a protein-bound uremic toxin and interacts with free oxygen radicals, which can induce cell damages. However, the clinical consequences of CMPF accumulation in haemodialysis patients remain poorly documented. Read More

View Article
May 2018
9 Reads

Primary bacterial ventriculitis in adults, an emergent diagnosis challenge: report of a meningoccal case and review of the literature.

BMC Infect Dis 2018 May 18;18(1):226. Epub 2018 May 18.

Infectious Disease, Rouen University Hospital, Rouen, France.

Background: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. Read More

View Article
May 2018
3 Reads

Effects of various generations of iterative CT reconstruction algorithms on low-contrast detectability as a function of the effective abdominal diameter: A quantitative task-based phantom study.

Phys Med 2018 Apr 13;48:111-118. Epub 2018 Apr 13.

Institute of Radiation Physics, Lausanne University Hospital, Rue du Grand-Pré 1, 1007 Lausanne, Switzerland.

Purpose: To investigate how various generations of iterative reconstruction (IR) algorithms impact low-contrast detectability (LCD) in abdominal computed tomography (CT) for different patient effective diameters, using a quantitative task-based approach.

Methods: Investigations were performed using an anthropomorphic abdominal phantom with two optional additional rings to simulate varying patient effective diameters (25, 30, and 35 cm), and containing multiple spherical targets (5, 6, and 8 mm in diameter) with a 20-HU contrast difference. The phantom was scanned using routine abdominal protocols (CTDI, 5. Read More

View Article
April 2018
4 Reads

Diagnostic and management of life-threatening Adult-Onset Still Disease: a French nationwide multicenter study and systematic literature review.

Crit Care 2018 Apr 11;22(1):88. Epub 2018 Apr 11.

Service de Médecine Interne, PHU3, CHU Hôtel-Dieu, 44093, Nantes, France.

Background: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder. A few patients develop organ complications that can be life-threatening. Our objectives were to describe the disease course and phenotype of life-threatening AOSD, including response to therapy and long-term outcome. Read More

View Article
April 2018
8 Reads

Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation.

Arterioscler Thromb Vasc Biol 2018 May 15;38(5):1134-1146. Epub 2018 Mar 15.

From the Inserm, UMR1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, Toulouse, Cedex 4, France (A. Briot, P.D., F.V., C.B., A. Bouloumié).

Objective: Adipose tissue (AT) dysfunction associated with obesity or aging is a major cause for lipid redistribution and the progression of cardiometabolic disorders. Our goal is to decipher the contribution of human AT microvascular endothelial cells (ECs) in the maintenance of fatty acid (FA) fluxes and the impact of senescence on their function.

Approach And Results: We used freshly isolated primary microvascular ECs from human AT. Read More

View Article
May 2018
4 Reads

[Antimalarial drug retinopathy].

Rev Med Interne 2018 May 26;39(5):364-368. Epub 2018 Feb 26.

Hospices civils de Lyon, centre Hospitalier Lyon Sud, département de Rhumatologie, 69310 Pierre-Bénite, France; Université Lyon 1, Lyon, France.

Introduction: Antimalarial drugs are largely used for the treatment of various systemic diseases. They can cause toxic retinopathy, which can lead to blindness.

Observation: We report the case of a 32-year-old male with a systemic lupus erythematosus treated with hydroxychloroquine 400mg per day and then chloroquine 300mg per day during 8 and 9years respectively. Read More

View Article
May 2018
1 Read

A new local muscle flap for elbow coverage-the medial triceps brachii flap: anatomy, surgical technique, and preliminary outcomes.

J Shoulder Elbow Surg 2018 Apr 1;27(4):733-738. Epub 2018 Feb 1.

Plastic Surgery, Hand Surgery and Burns Unit, FX Michelet Center, University Hospital of Bordeaux, Bordeaux, France.

Background: The medial triceps brachii is vascularized by the middle collateral artery and the arterial circle of the elbow. This vascularization allows a distal pedicled use to cover soft tissue defects of the elbow. We report our experience using this flap to cover traumatic and postsurgical wounds. Read More

View Article
April 2018
3 Reads

Ultrasonography and magnetic resonance imaging changes in patients with polymyalgia rheumatica treated by tocilizumab.

Arthritis Res Ther 2018 Jan 25;20(1):11. Epub 2018 Jan 25.

Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France.

Background: This study assessed inflammatory changes using ultrasound (US) and magnetic resonance imaging (MRI) in patients taking tocilizumab for polymyalgia rheumatica (PMR).

Methods: Eighteen patients were included in the prospective open-label TENOR study and received three tocilizumab infusions, without corticosteroids. B-mode and power Doppler US and MRI (T1 and T2-short time inversion recuperation weighted sequences) of the hips and shoulders were performed at weeks 0, 2, and 12. Read More

View Article
January 2018
16 Reads

Téléconsultation d'anesthésie au domicile : une enquête d'acceptabilité.

Can J Anaesth 2018 May 20;65(5):597-599. Epub 2017 Dec 20.

Département d'anesthésie, CHRU Nancy, Nancy, France.

View Article
May 2018
3 Reads

Cannabinoid hyperemesis syndrome: Review of the literature and of cases reported to the French addictovigilance network.

Drug Alcohol Depend 2018 Jan 7;182:27-32. Epub 2017 Nov 7.

Addictovigilance des Pays de la Loire, Service de pharmacologie clinique, Institut de biologie, CHU de Nantes, 44093 Nantes Cedex 1, France; INSERM UMR U1246 SPHERE, Institut de Recherche en Santé 2, 22 Boulevard Benoni-Goullin, 44200 Nantes, France. Electronic address:

Background: Cannabinoid hyperemesis syndrome is a variant of cyclical vomiting syndrome in a context of chronic cannabis usage. Our aim was to compare French cases to those identified in the international literature in order to further our knowledge of the clinical criteria, pathophysiology and treatments for cannabinoid hyperemesis syndrome.

Methods: We analysed cases reported in the international literature up to 30 June 2017, obtained from the MEDLINE, PsycINFO and The Cochrane Library databases; we selected relevant articles based on title and abstract. Read More

View Article
January 2018
6 Reads

[Consumption of psychoactive drugs and exposure to bacterial toxins carried by food: a dangerous association].

Gac Sanit 2017 Nov 1. Epub 2017 Nov 1.

Unidad de Gestión Clínica de Prevención, Promoción y Vigilancia de la Salud Interniveles, Distrito Sanitario Granada Metropolitano, Granada, España.

Objective: To describe and analyse from a clinical and epidemiological point of view, a food borne outbreak in a psychiatric institution in Granada, in 2015, and to examine whether treatment with psychoactive drugs constitutes a risk factor for the development of a food borne disease, analysing the degree of susceptibility according to the therapeutic group consumed.

Method: Ambispective cohort study. Residents were the unit of analysis. Read More

View Article
November 2017
3 Reads

Different co-culture systems have the same impact on bovine embryo transcriptome.

Reproduction 2017 11;154(5):695-710

UMR BDRINRA, ENVA, Université Paris Saclay, Jouy-en-Josas, France

During the last few years, several co-culture systems using either BOEC or VERO feeder cells have been developed to improve bovine embryo development and these systems give better results at high oxygen concentration (20%). In parallel, the SOF medium, used at 5% O, has been developed to mimic the oviduct fluid. Since 2010s, the SOF medium has become popular in improving bovine embryo development and authors have started to associate this medium to co-culture systems. Read More

View Article
November 2017

Evaluation of donor site morbidity after medial triceps brachii free flap for lower limb reconstruction.

Arch Orthop Trauma Surg 2017 Dec 8;137(12):1659-1666. Epub 2017 Sep 8.

Plastic Surgery and Burns Unit, University Hospital of Bordeaux, FX Michelet Center, Place Amelie Raba Leon, 33076, Bordeaux, France.

Introduction: The medial head of the triceps brachii muscle (MTB)-free flap is an attractive solution to cover small-to-medium defects of the lower limb. This muscular head has no well-identified function, suggesting minimal impact of its removal on elbow mobility. The aim of this study was to evaluate the safety and reliability of the harvest procedure and the functional and cosmetic morbidity of this donor site. Read More

View Article
December 2017
1 Read

Interfacial tension of reactive, liquid interfaces and its consequences.

Adv Colloid Interface Sci 2017 Sep 24;247:185-197. Epub 2017 Jul 24.

Laboratoire de Physique des Solides, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Orsay Cedex 91405, France. Electronic address:

Dispersions of immiscible liquids, such as emulsions and polymer blends, are at the core of many industrial applications which makes the understanding of their properties (morphology, stability, etc.) of great interest. A wide range of these properties depend on interfacial phenomena, whose understanding is therefore of particular importance. Read More

View Article
September 2017
1 Read

Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations.

Sci Rep 2017 Jul 28;7(1):6766. Epub 2017 Jul 28.

MRC Centre for Outbreak Analysis and Modelling, Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, W2 1PG, United Kingdom.

Transmission blocking vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown. The efficacy of two lead candidates targeting Pfs25 and Pfs230 antigens to prevent onwards transmission of naturally occurring parasites to a local mosquito strain is assessed using direct membrane feeding assays and murine antibodies in Burkina Faso. The transmission blocking activity of both candidates depends on the level of parasite exposure (as assessed by the mean number of oocysts in control mosquitoes) and antibody titers. Read More

View Article
July 2017
43 Reads

[G6PD deficiency in females with neonatal revelation. Report of four cases].

Arch Pediatr 2017 Sep 25;24(9):865-871. Epub 2017 Jul 25.

Service de néonatologie, pôle-de-périnatalité, hôpital Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France; Centre national de référence en hémobiologie périnatale, pôle-de-périnatalité, hôpital Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human erythrocyte enzyme defect, estimated to affect approximately 4 million people worldwide. It is associated with severe neonatal hyperbilirubinemia, which may lead to bilirubin encephalopathy and kernicterus, and with hemolytic crisis. G6PD deficiency is an X-linked enzymopathy affecting hemizygous males, homozygous females, and also a subset of heterozygous females via chromosome X inactivation. Read More

View Article
September 2017
2 Reads

Assessment of biosecurity and control measures to prevent incursion and to limit spread of emerging transboundary animal diseases in Europe: An expert survey.

Vaccine 2017 10 24;35(44):5956-5966. Epub 2017 Jul 24.

SAFOSO AG, Waldeggstrasse 1, CH 3097 Bern Liebefeld, Switzerland.

Decision-makers and risk managers are often called upon to prioritise on and recommend suitable measures to prevent the risk of introduction and spread of pathogens. The main objective of this study was to assess the perceptions of experts in Italy, Switzerland and the United Kingdom concerning the importance, effectiveness, feasibility, costs and acceptability of selected biosecurity measures to prevent the introduction and limit the spread of rabies, blue tongue (BT) and classical swine fever (CSF). After identifying the most relevant measures by the project team, an expert knowledge elicitation was implemented through a questionnaire. Read More

View Article
October 2017
13 Reads

Investigation of pre-XDR Beijing Mycobacterium tuberculosis transmission to a healthcare worker in France, 2016.

J Hosp Infect 2017 Dec 30;97(4):414-417. Epub 2017 Jun 30.

Centre Hospitalier Universitaire de Montpellier, Laboratoire de Bactériologie, Montpellier, France; MIVEGEC, UMR IRD 224-CNRS 5290-Université de Montpellier, Montpellier, France.

A case of occupational contamination of a healthcare worker by a pre-extensively drug-resistant (pre-XDR) Beijing strain of Mycobacterium tuberculosis at the University Hospital of Montpellier, France is reported. The index case was identified using genetic fingerprinting of isolates. This report underscores the risk of healthcare-associated contamination by pre-XDR tuberculosis (TB) in low-incidence countries and the importance of molecular tools for TB care. Read More

View Article
December 2017
2 Reads

A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer.

Sci Rep 2017 Jun 30;7(1):4474. Epub 2017 Jun 30.

Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, 28029, Spain.

Epidemiological studies indicate that patients suffering from Alzheimer's disease have a lower risk of developing lung cancer, and suggest a higher risk of developing glioblastoma. Here we explore the molecular scenarios that might underlie direct and inverse co-morbidities between these diseases. Transcriptomic meta-analyses reveal significant numbers of genes with inverse patterns of expression in Alzheimer's disease and lung cancer, and with similar patterns of expression in Alzheimer's disease and glioblastoma. Read More

View Article
June 2017
12 Reads

The brain of René Descartes (1650): A neuro-anatomical analysis.

J Neurol Sci 2017 Jul 20;378:12-18. Epub 2017 Apr 20.

Section of Human Paleontology, UMR 7194 (CNRS), Department of Prehistory, National Museum of Natural History, Musée de l'Homme, Paris, France.

The skull of René Descartes is held in the National Museum of Natural History since the 19th c. Up to date, only anthropological examinations were carried out, focusing on the cranial capacity and phrenological interpretation of the skull morphology. Using CT-scan based 3D technology, a reconstruction of the endocast was performed, allowing for its first complete description and inter-disciplinary analysis: assessment of metrical and non-metrical features, retrospective diagnosis of anatomical anomalies, and confrontation with neuro-psychological abilities of this well-identified individual. Read More

View Article
July 2017
11 Reads

Antimalarial drug retinopathy: A typical « Bull's eyes » appearance of fundus.

Joint Bone Spine 2018 May 13;85(3):369. Epub 2017 May 13.

Département de Rhumatologie, hospices civils de Lyon, centre hospitalier Lyon Sud, 69495 Pierre-Bénite, France; Université Lyon 1, 69000 Lyon, France.

View Article
May 2018
5 Reads

Our auditory results using the Vibrant Soundbridge on the long process of the incus: 20 years of data.

Auris Nasus Larynx 2018 Feb 9;45(1):66-72. Epub 2017 Mar 9.

Department of ENT & Head and Neck Surgery, CHU UCL-Namur, Université catholique de Louvain, Avenue G. Therasse 1, 5530 Mont-Godinne, Belgium; Audiophonological Center of CHU UCL-Namur, Université Catholique de Louvain, Avenue G. Therasse 1, 5530 Mont-Godinne, Belgium; Anatomy Department, Faculty of Medicine, University of Namur, Namur, Belgium.

Objective: After 20 years of experience with different types of middle ear implants, we analyzed our database about the Vibrant Soundbridge (VSB) to know the rate of complications, the effect on the residual hearing and the audiometric gain in our center.

Method: The study was retrospective and included all VSB implants bound to the long process of the incus in our tertiary medical center between january 1999 and february 2015. We observed the effect of surgery on residual hearing by comparing bone and air conduction thresholds before and after implantation. Read More

View Article
February 2018
10 Reads

Surgical management of hepato-pancreatic metastasis from renal cell carcinoma.

World J Gastrointest Oncol 2017 Feb;9(2):70-77

Nikolaos A Chatzizacharias, Anais Rosich-Medina, Khaled Dajani, Simon Harper, Emmanuel Huguet, Siong S Liau, Raaj K Praseedom, Asif Jah, Department of HPB and Transplant Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridgeshire CB2 0QQ, United Kingdom.

Aim: To investigate the outcomes of liver and pancreatic resections for renal cell carcinoma (RCC) metastatic disease.

Methods: This is a retrospective, single centre review of liver and/or pancreatic resections for RCC metastases between January 2003 and December 2015. Descriptive statistical analysis and survival analysis using the Kaplan-Meier estimation were performed. Read More

View Article
February 2017
5 Reads

A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments.

Int J Mol Sci 2017 Feb 17;18(2). Epub 2017 Feb 17.

CHU Estaing et Université Clermont Auvergne, Hematology (Biology) et EA 7453 CHELTER, F-63000 Clermont-Ferrand, France.

Gaucher disease (GD, ORPHA355) is a rare, autosomal recessive genetic disorder. It is caused by a deficiency of the lysosomal enzyme, glucocerebrosidase, which leads to an accumulation of its substrate, glucosylceramide, in macrophages. In the general population, its incidence is approximately 1/40,000 to 1/60,000 births, rising to 1/800 in Ashkenazi Jews. Read More

View Article
February 2017
12 Reads

Renal involvement in lysinuric protein intolerance: contribution of pathology to assessment of heterogeneity of renal lesions.

Hum Pathol 2017 Apr 11;62:160-169. Epub 2017 Jan 11.

Pathology Department Hôpital Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Université Sorbonne Paris Cité, 75015, Paris, France. Electronic address:

Lysinuric protein intolerance (LPI) is a rare autosomal recessive disease caused by mutations in the SLC7A7 gene encoding the light subunit of a cationic amino acid transporter. Symptoms mimic primary urea cycle defects but dysimmune symptoms are also described. Renal involvement in LPI was first described in the 1980s. Read More

View Article
April 2017
42 Reads

Absorption and metabolization of sex hormones and their transformation into contraceptive technologies: the paths taken by medical thought in Brazil.

Cien Saude Colet 2017 Jan;22(1):107-116

Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Fiocruz. Av. Rui Barbosa 716, Flamengo. 22250-020 Rio de Janeiro RJ Brasil.

The article analyses knowledge assimilation and the development of clinical and research practices relating to sex hormones among Brazilian gynaecologists. It discusses the paths taken by medical thought from the reception of the hormones to their transformation into contraceptives. Our objective is to comprehend styles of introducing and disseminating medical technologies in the area of reproductive health in Brazil. Read More

View Article
January 2017
11 Reads

Characteristics of Aspergillus fumigatus in Association with Stenotrophomonas maltophilia in an In Vitro Model of Mixed Biofilm.

PLoS One 2016 21;11(11):e0166325. Epub 2016 Nov 21.

EA 7380 Dynamyc, Université Paris Est Créteil, Ecole nationale vétérinaire de d'Alfort, IMRB, Créteil, France.

Background: Biofilms are communal structures of microorganisms that have long been associated with a variety of persistent infections poorly responding to conventional antibiotic or antifungal therapy. Aspergillus fumigatus fungus and Stenotrophomonas maltophilia bacteria are examples of the microorganisms that can coexist to form a biofilm especially in the respiratory tract of immunocompromised patients or cystic fibrosis patients. The aim of the present study was to develop and assess an in vitro model of a mixed biofilm associating S. Read More

View Article
June 2017
11 Reads

[Treatment and progression of acute communautary osteoarticular infections in healthy children: A retrospective monocentric study of 64 patients].

Arch Pediatr 2016 Nov 10;23(11):1124-1134. Epub 2016 Oct 10.

Service de pédiatrie générale, hôpital Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France; Groupe de pathologie infectieuse pédiatrique de la Société française de pédiatrie, hôpital Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France.

Introduction: The prognosis of osteoarticular infections has improved over the past 20 years but it still remains potentially severe. The treatment of these infections has been simplified and shortened. In 2008, the Pediatric Infectious Disease Group (GPIP) established new therapeutic guidelines in order to standardize treatment in France. Read More

View Article
November 2016

Transcript Abundance of Photorhabdus Insect-Related (Pir) Toxin in Manduca sexta and Galleria mellonella Infections.

Toxins (Basel) 2016 Sep 29;8(10). Epub 2016 Sep 29.

Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA.

In this study, we assessed pirAB toxin transcription in (strain TT01) (Enterobacteriaceae) by comparing mRNA abundance under in vivo and in vitro conditions. In vivo assays considered both natural and forced infections with two lepidopteran hosts: and . Three portals of entry were utilized for the forced infection assays: (a) integument; (b) the digestive route (via mouth and anus); and (c) the tracheal route (via spiracles). Read More

View Article
September 2016
1 Read

Forest soils in France are sequestering substantial amounts of carbon.

Sci Total Environ 2017 Jan 14;574:616-628. Epub 2016 Oct 14.

UCL-ELI, Université catholique de Louvain, Earth and Life Institute, Croix du Sud 2, L7.05.09, BE-1348 Louvain-la-Neuve, Belgium. Electronic address:

The aim of this study was to assess whether French forest soils are sources or sinks of carbon and to quantify changes in soil organic carbon (SOC) stocks over time by resampling soil in long-term forest monitoring plots. Within each plot, and for each survey, soils were sampled at five points selected in five subplots and divided into layers. Composite samples were produced for each layer and subplot, then analysed for mass, bulk density and SOC. Read More

View Article
January 2017
1 Read

What does the geography of parthenogenesis teach us about sex?

Philos Trans R Soc Lond B Biol Sci 2016 10;371(1706)

Department of Evolutionary Biology and Environmental Studies, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland Centre of Excellence in Biological Interactions, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

Theory predicts that sexual reproduction is difficult to maintain if asexuality is an option, yet sex is very common. To understand why, it is important to pay attention to repeatably occurring conditions that favour transitions to, or persistence of, asexuality. Geographic parthenogenesis is a term that has been applied to describe a large variety of patterns where sexual and related asexual forms differ in their geographic distribution. Read More

View Article
October 2016
5 Reads

Strong evidence for the presence of the tick Hyalomma marginatum Koch, 1844 in southern continental France.

Ticks Tick Borne Dis 2016 10 6;7(6):1162-1167. Epub 2016 Aug 6.

Faculty of Veterinary Medicine, University of Zaragoza, Spain. Electronic address:

Hyalomma ticks can transmit several human and animal pathogens in Eurasia and Africa. Interest in Hyalomma marginatum has increased since the recent (re)emergence of Crimean-Congo Hemorrhagic fever in the Palearctic region. Until now, continental France has been considered free of this tick species. Read More

View Article
October 2016
14 Reads

Second-Generation central venous catheter in the prevention of bloodstream infection: a systematic review.

Rev Lat Am Enfermagem 2016 Aug;24:e2722

PhD, Associate Professor, Escola Paulista de Enfermagem, Universidade Federal de São Paulo, São Paulo, SP, Brazil. 7 PhD, Associate Professor, Departamento de Enfermagem, Universidade Federal do Paraná, Curitiba, PR, Brazil.

Objective: to evaluate the effectiveness and safety in the use of second-generation central venous catheters impregnated in clorhexidine and silver sulfadiazine when compared with other catheters, being them impregnated or not, in order to prevent the bloodstream infection prevention.

Method: systematic review with meta-analysis. Databases searched: MEDLINE, EMBASE, CINAHL, LILACS/SciELO, Cochrane CENTRAL; search in Congress Proceedings and records from Clinical Trials. Read More

View Article
August 2016
21 Reads

Isolated rectus abdominis metastasis from melanoma-An extremely rare case.

Int J Surg Case Rep 2016 22;26:121-3. Epub 2016 Jul 22.

HUA (Hospital Universitario de Araba), C/Olaguibel, 27, 01004 Vitoria, Spain; UPV/EHU (Universidad del País Vasco), University of the Basque Country, Vitoria, Spain. Electronic address:

Introduction: Melanoma is a health problem world-wide. Its incidence has tripled in the last decade. The main cause of death in melanoma patients is widespread metastases. Read More

View Article
September 2016
6 Reads

Validation of STA-Liatest D-Di assay for exclusion of pulmonary embolism according to the latest Clinical and Laboratory Standard Institute/Food and Drug Administration guideline. Results of a multicenter management study.

Blood Coagul Fibrinolysis 2017 Apr;28(3):254-260

aDepartment of Vascular Medicine, Grenoble University Hospital, Grenoble, France bPathology and Laboratory Medicine, Ohio State University, Columbus, Ohio, USA cHematology Laboratory, University Hospital, Dijon, France dPathology and Laboratory Medicine, Medical University South Carolina, Charleston, South Carolina, USA eDepartment of Haematology, Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Canada fDepartment of Haematology, Santa Barbara General Hospital, Soria gLaboratio de Coagulación, Centro Sanitario Hospital General Universitario de Alicante, Alicante, Spain hDepartment of Angiology and Blood Coagulation 'Marino Golinelli', Bologna University Hospital Corporation, Policlinica S. Orsola Malpighi, Bologna iCoagulation Service and Thrombosis Research Unit, Scientific Institute San Raffaele, Milano, Italy.

: Combined clinical pretest probability (PTP) and D-dimer testing have great diagnostic value for pulmonary embolism exclusion. To harmonize performance levels of D-dimer assays available on the market, the Clinical and Laboratory Standard Institute (CLSI) has published a guideline, endorsed by the US Food and Drug Administration (FDA). Such guideline specifies the ideal D-dimer assay characteristic and target population. Read More

View Article
April 2017
48 Reads

A relevant exposure to a food matrix contaminated environmentally by polychlorinated biphenyls induces liver and brain disruption in rats.

Chemosphere 2016 Oct 13;161:80-88. Epub 2016 Jul 13.

Univ. Grenoble Alpes, Laboratory of Fundamental and Applied Bioenergetics, Environmental and Systems Biology, Inserm, U1055, BP 53, 38041 Grenoble Cedex 9, France. Electronic address:

Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants present in dietary fats. Most studies evaluating PCB effects have been conducted with a single compound or a mixture of PCBs given as a single acute dose. The purpose of this study was to evaluate in vivo PCB toxicity in a realistic model of exposure: a low daily dose of PCBs (twice the tolerable daily intake (TDI)), chronically administered (8 weeks) to rats in contaminated goat milk. Read More

View Article
October 2016
13 Reads

Characterization of an A-kinase anchoring protein-like suggests an alternative way of PKA anchoring in Plasmodium falciparum.

Malar J 2016 Apr 29;15:248. Epub 2016 Apr 29.

IRD UMR216-MERIT, Faculté de Pharmacie, Mère et enfant face aux Infections Tropicales, Paris, France.

Background: The asexual intra-erythrocytic multiplication of the malaria parasite Plasmodium falciparum is regulated by various molecular mechanisms. In eukaryotic cells, protein kinases are known to play key roles in cell cycle regulation and signaling pathways. The activity of cAMP-dependent protein kinase (PKA) depends on A-kinase anchoring proteins (AKAPs) through protein interactions. Read More

View Article
April 2016
19 Reads