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    2096 results match your criteria Anais da Academia Brasileira de Ciencias[Journal]

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    Science communication podcasting in Brazil: the potential and challenges depicted by two podcasts.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1891-1901
    Dragões de Garagem Podcast, Rua do Mercado, 19, Quadra 5, Lote 1, 74523-330 Goiânia, GO, Brazil.
    Podcasts - online distributed audio files - are easy access and production media, which can be used for Scientific Communication (SC) but few are presented in Portuguese. The objective of this work is to perform a case study with data from a survey for two Brazilian SC podcasts (Dragões de Garagem and Fronteiras da Ciência) to evaluate the increase of science podcast media in Brazil, the involved potential, their advantages, shortcomings, and perspectives. We noted an increase of listeners over the years, probably due to the internet popularization and the massive increase of mobile phones. Read More

    Monitoring structures with optical fibers: infiltration detection.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1865-1872
    Hydraulic Engineering Laboratory/Arbeitsbereich Wasserbau, University of Innsbruck, Technikerstrasse, 13 A-6020 Innsbruck, Austria.
    The use of sensors and optical fibers for monitoring structures is continuously growing. Strains, displacements, accelerations, temperatures are just a few of the monitoring possibilities. In the case of dam structures, concrete face rockfill dams constitute a type of structures where the monitoring of water infiltrations is of particular interest. Read More

    A Dual-mode model interpretation of CO2/CH4 permeability in polysulfone membranes at low pressures.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1855-1864
    Exact Sciences Center and Technologies/PPGEPROTEC, Caxias do Sul University/UCS, Av. Francisco Getúlio Vargas, 1130, Petrópolis, 95070-560 Caxias do Sul, RS, Brazil.
    An asymmetric membrane of polysulfone (PSf) was synthesized by phase inversion method. Permeation experiments were carried out between 2 to 5 bar pressure, and at temperatures 20 to 45°C. The dense-selective layer of PSf membrane presents regular thickness (about 5 µm), and was not possible to observe the formation of macrovoids in porous layer. Read More

    Genetic transformation of Brachiaria brizantha cv. Marandu by biolistics.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1789-1797
    Embrapa - Recursos Genéticos e Biotecnologia, Parque Estação Biológica, s/n, Final W5 Norte, 70770-917 Brasília, DF, Brazil.
    Brachiaria brizantha is a forage grass well adapted to tropical areas and cultivated in millions of hectares in Brazil. The apomictic mode of reproduction in this species, in addition to differences in ploidy between sexual and apomictic plants, impairs crossbreeding. The development of a methodology to transform apomictic cultivars will provide an option to introduce agronomic important traits to B. Read More

    The combination of compost or biochar with urea and NBPT can improve nitrogen-use efficiency in maize.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1695-1703
    Instituto de Ciências Agrárias, Universidade Federal de Uberlândia, Rua Amazonas, s/n, 38400-902 Uberlândia, MG, Brazil.
    The addition of organic residues to agricultural soils has been used as a practical alternative to improve crop quality and health. The objective of this work was to evaluate maize physiological and nutritional responses to the application of compost and biochar combined with urea (N) and N-(n-butyl) thiophosphoric triamide (NBPT). The experiment was performed in plastic pots with 3 kg of soil under greenhouse conditions for 30 days. Read More

    Genetic diversity assessed by microsatellite markers in the amphicarpic species Trifolium polymorphum Poir.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1685-1693
    Sociedade Educacional Três de Maio, Rua Santa Rosa, 2405, 98910-000 Três de Maio, RS, Brazil.
    Trifolium polymorphum Poir. is an amphicarpic forage legume from southern Brazil, Uruguay, Argentina, Paraguay and Chile. Information on the genetic diversity of natural populations in natural grasslands in southern Brazil is limited. Read More

    Do carcasses of lambs finished on commercial production systems meet market standards?
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1671-1683
    Embrapa Caprinos e Ovinos, Fazenda Três Lagoas, Estrada Sobral/Groaíras, Km 4, Caixa Postal 71, 62010-970 Sobral, CE, Brazil.
    This study aimed to characterize a commercial lamb finishing system using animals of undefined breed from production to slaughter by analyzing performance, carcass traits, yield of commercial cuts, and the quality and meat acceptance of different slaughter groups, as to evaluate whether this system provides the market with a standardized product. The lots were not homogeneous for yield of commercial cuts and performance and morphometric traits evaluated in vivo. The groups were heterogeneous to 75% of the 13 carcass traits evaluated, among them, hot and cold carcass weights, hot and cold carcass yields, carcass grade finishing and biological yield. Read More

    Olfactory deficit as a result of clozapine withdrawal syndrome in an animal model of schizophrenia: preliminary results.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1659-1663
    Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Unidade Acadêmica de Ciências da Saúde, Laboratório de Neurociências, Av. Universitária, 1105, Bloco S, Sala 5/ subsolo, Universitário, 88806-000 Criciúma, SC, Brazil.
    Clozapine is an antipsychotic that produces serious withdrawal effects in schizophrenic patients. Olfactory deficits are well known as part of negative symptoms, but it is not known whether antipsychotic use and/or withdrawal are implicated. Then, we tested clozapine withdrawal in association with two widely used schizophrenia models: Neonatal immune challenge by Polycitidilic-polyinosinic acid (polyI:C) and ketamine. Read More

    Mineral supplementation stimulates the immune system and antioxidant responses of dairy cows and reduces somatic cell counts in milk.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1649-1658
    Programa de Pós-Graduação em Zootecnia, Universidade do Estado de Santa Catarina /UDESC, Rua Beloni Trombeta Zanin, 680E, Santo Antônio, 89815-630 Chapecó, SC, Brazil.
    The aim of this study was to evaluate whether the use of subcutaneous mineral supplementation would affect metabolic parameters, immunological response, milk quality and composition of dairy cows in the postpartum period. Twelve pregnant primiparous Holstein cows, were divided into two groups: six animals supplemented with the mineral complex (magnesium, phosphorus, potassium, selenium and copper), and six animals used as controls. Milk samples were collected every two other weeks postpartum up to sixty days of lactation to analyze composition and quality. Read More

    Morpho-anatomical, physiological and biochemical changes in rubber tree seeds.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1625-1641
    Departamento de Biologia Vegetal, Universidade Federal de Viçosa, Avenida Ph Rolfs, s/n, Campus Universitário, 36570-000 Viçosa, MG, Brazil.
    The physical, physiological and biochemical changes during the development until the dispersal of rubber tree seeds were evaluated with the purpose of estimating the point at physiological maturity. A total of 30 plants were selected at different points in a commercial planting area and had their flowers marked during the anthesis and every 15 days after marking. Fruits and seeds were collected for analysis of moisture content, dry matter, diameter and length. Read More

    Distribution pattern of anurans from three mountain complexes in southeastern Brazil and their conservation implications.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1611-1623
    Programa de Pós-Graduação em Ecologia e Conservação, Universidade Federal de Mato Grosso do Sul, Instituto de Biociências, Cidade Universitária, Pioneiros, 79070-900 Campo Grande, MS, Brazil.
    Biogeographic tools support spatial distribution pattern hypotheses and help to determine priority areas for conservation. Our aim was to verify biogeographic patterns for anurans in three mountain complexes in southeastern Brazil, as well as to discuss the status of species conservation recorded and the biogeographical units evaluated. We selected 16 areas distributed in the Serra da Mantiqueira complex, south of Serra do Espinhaço and Serra da Canastra. Read More

    Effect of herbicides in the oxidative stress in crop winter species.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1533-1542
    Programa de Pós-Graduação em Ciência e Tecnologia Ambiental, Universidade Federal da Fronteira Sul, Rodovia RS 135, Km 72, 99700-970 Erechim, RS, Brazil.
    Most herbicides applied in crop field, stay in the soil for a period, affecting next crop or even the plants using as green manure. Nowadays, the use of herbicides grow to increase productivity, mainly in the grain producing region north of Rio Grande do Sul state. The objective of this study was to evaluate the effects of herbicides fomesafen and sulfentrazone on antioxidant system in Avena sativa1, Vicia sativa2, Raphanus sativus and Lupinus albus. Read More

    The characterization and comparison of exopolysaccharides from two benthic diatoms with different biofilm formation abilities.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1503-1519
    College of Environmental Science & Engineering, Yangzhou University,196# of Huayang West Street, Hanjiang District, Yangzhou City, 225127 Jiangsu Province, China.
    Exopolysaccharide (EPS) of two benthic diatoms, Amphora sp. and Stauroneis sp., with different biofilm formation abilities were investigated. Read More

    ABA regulation of post-germination desiccation tolerance in wheat cultivars contrasting in drought tolerance.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1493-1501
    Department of Biochemistry, College of Basic Sciences & Humanities, Punjab Agricultural University, 141004, Ludhiana, India.
    Post-germination desiccation tolerance (DT) was studied in two wheat cultivars. Effect of pretreatment of abscisic acid (ABA)/ osmotic/ salt/ heat stress was also studied. One day (d)-old seedlings of wheat cultivars PBW 644 (drought tolerant) and PBW 343 (drought susceptible) were exposed to ABA/stress treatment for next 1 d, desiccated for 4 d and subsequently rehydrated for 4 d. Read More

    Drying and reduction in sensitivity to desiccation of seeds of Alibertia edulis: the influence of fruit ripening stage.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1481-1491
    Faculdade de Ciências Agrárias/FCA, Universidade Federal da Grande Dourados/UFGD, Rodovia Dourados, Itahum, Km 12, Cidade Universitária, 79804-970 Dourados, MS, Brazil.
    The intense environmental degradation in tropical regions suitable for agriculture has decreased native forest populations of plants with important fruits and medicinal properties. Alibertia edulis is a native tree from the Brazilian Cerrado. Knowledge about the effects of drying and storage on the physiological behavior of its seeds may aid in its sustainable exploitation and conservation. Read More

    Is there still room to explore cyclodextrin glycosyltransferase-producers in Brazilian biodiversity?
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1473-1480
    Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235, s/n, Setor Universitário, 74605-050 Goiânia, GO, Brazil.
    In the present work, different Brazilian biomes aiming to identify and select cyclodextrin glycosyltransferase-producer bacteria are explored. This enzyme is responsible for converting starch to cyclodextrin, which are interesting molecules to carry other substances of economic interest applied by textile, pharmaceutical, food, and other industries. Based on the enzymatic index, 12 bacteria were selected and evaluated, considering their capacity to produce the enzyme in culture media containing different starch sources. Read More

    Changes in the phenylalanine ammonia lyase activity, total phenolic compounds, and flavonoids in Prosopis glandulosa treated with cadmium and copper.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1465-1472
    Tecnológico Nacional de México, Campus Tuxtla Gutiérrez, Carretera Panaméricana, Km 1080, Casilla Postal 29050, Chiapas, Mexico.
    The aim of the present work is to evaluate the changes on the phenylalanine ammonia lyase (PAL) activity, phenolic compounds accumulation and photochemical efficiency in leaves of P. glandulosa treated with Cd2+ (0.001 M) and Cu2+ (0. Read More

    Effects of two bisbenzylisoquinoline alkaloids, Antioquine and Tetrandrine, compared to Verapamil in Rat Thoracic Aorta.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1459-1463
    Facultad de Química y Biología, Universidad de Santiago de Chile, Avenida Libertador Bernardo O'Higgins, 3363, Estación Central, Codigo Postal 9160000 Santiago, Chile.
    The objective of this study was to compare two alkaloids (antioquine and tetrandrine) with verapamil; knowing that the smooth muscle respond to KCl and relationships with calcium. The effects of antioquine and tetrandrine, was studied in adults Wistar rat with modified methods used in the determination of aorta contractility and compared with verapamil effect in the same assays. The analysis of the effect of a drug or extract on aortic reactivity included maximal relaxation or maximal contraction (Cmax) (Phase 1). Read More

    The influence of environmental variables in the reproductive performance of Macrobrachium amazonicum (Heller, 1862) (Caridea: Palaemonidae) females in a continental population.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1445-1458
    Departamento de Ciências Biológicas, Laboratório de Biologia de Camarões Marinhos e de Água Doce, Faculdade de Ciências, Universidade Estadual Paulista/UNESP, Av. Engenheiro Luiz Edmundo Carrijo Coube, 14-01, Vargem Limpa, 17033-360 Bauru, SP, Brazil.
    Macrobrachium amazonicum is a commercially important freshwater prawn with a high degree of reproductive plasticity. The species is classified into two groups: coastal populations, with larger individuals exhibiting high fecundity and needing brackish water for larval development; and continental populations, with smaller specimens exhibiting low fecundities and completing metamorphosis in freshwater. The objective of this study was to investigate the influence of environmental factors in the fecundity, egg size and volume, and reproductive output in females of M. Read More

    Comparative cytogenetic analysis in Erythrolamprus snakes (Serpentes: Dipsadidae) from Argentina.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1417-1429
    Instituto de Ecología, Genética y Evolución de Buenos Aires/IEGEBA - CONICET, Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Avenida Intendente Güiraldes, 2160, 4º piso, Pabellón II (C1428EHA), Ciudad Autónoma de Buenos Aires, Argentina.
    We described the karyotypes of five snake taxa from Argentina: Erythrolamprus almadensis, E. ceii, E. poecilogyrus caesius, E. Read More

    The monotypic Brazilian genus Diacrodon is a synonym of Borreria (Spermacoceae, Rubiaceae): morphological and molecular evidences.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1397-1415
    Instituto de Botánica del Nordeste (UNNE-CONICET), Av. Sargento Cabral, 2131, c.c. 209, CP 3400, Corrientes, Argentina.
    Diacrodon is a monotypic genus of the tribe Spermacoceae (Rubiaceae), endemic to northeastern Brazil. Diacrodon compressus is frequently misidentified with a two lobed calyx species of Borreria, B. verticillata. Read More

    Density, abundance and extractive potential of the mangrove crab, Ucides cordatus (Linnaeus, 1763) (Brachyura, Ocypodidae): subsidies for fishery management.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1381-1395
    Universidade Estadual Paulista/UNESP, Instituto de Biociências/IB, Campus do Litoral Paulista/CLP, Laboratório de Biologia da Conservação de Crustáceos e Ambientes Costeiros, Praça Infante Dom Henrique, s/n, Parque Bitaru, 11330-900 São Vicente, SP, Brazil.
    Ucides cordatus is a relevant fishery resource of Brazilian mangroves and requires legal normative to sustainable use based on stock assessment and management. This study evaluated some population parameters (structure, density, abundance, fishery potential and stock) of this crab species in Brazil Southeast (São Paulo, State), discussing the use of the results to delineate fishery management strategies. Density was monthly evaluated (September 1998 to August 1999), using five sample quadrats of 2x2 m. Read More

    Reply to Castro et al. 2018 on "Holocene paleo-sea level changes along the coast of Rio de Janeiro, southern Brazil".
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1377-1380
    Grupo de Oceanografia Tropical/GOAT, UFBA, Travessa Barão de Jeremoabo, s/n, Campus Universitário de Ondina, LFNA, Sala 02, 40170-280 Salvador, BA, Brazil.
    Discussions are useful to the advance of science, and we appreciate the opportunity to discuss the paper by Castro et al. (2014) for the second time. Here we maintain the interpretations presented in our discussion paper (Angulo et al. Read More

    Comments to Angulo et al. 2016 on "Sea-level fluctuations and coastal evolution in the state of Rio de Janeiro, southeastern - Brazil" by Castro et al. 2014.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1369-1375
    Instituto de Geociências, Universidade de São Paulo/USP, Rua do Lago, 562, Cidade Universitária, 05580-080 São Paulo, SP, Brazil.
    Interpretation of sea-level indicators is essential when studying paleo sea-level fluctuations during the Holocene. Sea-level indicators may have different origins, such as geological (beachrocks) and biological (vermetids and barnacles). In order to reconstruct paleo sea-level, it is necessary to attribute an indicative meaning to each sea-level indicator. Read More

    The expression of neotectonics in the Pantanal da Nhecolândia, State of Mato Grosso do Sul - Brazil.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1293-1308
    Laboratório de Geoprocessamento para Aplicações Ambientais, Faculdade de Engenharias, Arquitetura e Urbanismo e Geografia, Universidade Federal de Mato Grosso do Sul, Unidade 7A, Cidade Universitária, s/n, 79070-900 Campo Grande, MS, Brazil.
    Pantanal da Nhecolândia is one of the most well-preserved areas in the State of Mato Grosso do Sul. Located in the southern part of the Taquari River megafan, it is in tectonic contact with the fault escarpments of the Maracaju-Campo Grande plateaus to the east and with the fault escarpments of the Bodoquena plateau to the west, which continue to north. To the south and to the north, the limits are marked respectively by the lineaments of the Negro and Taquari Rivers. Read More

    Chemical composition and antibacterial activity of essential oils from Citrus aurantifolia leaves and fruit peel against oral pathogenic bacteria.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1285-1292
    Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais, Campus Pouso Alegre, Avenida Maria da Conceição Santos, 900, Parque Real, 37550-000 Pouso Alegre, MG, Brazil.
    Tooth decay is a major public health problem which affects a large number of people in several countries. Even though more than 700 bacterial species have been detected in the oral cavity, Streptococcus and Lactobacillus stand out as the genera that cause tooth decay and other periodontal diseases. In this study, essential oils from Citrus aurantifolia leaves (CL-EO) and fruit peel (CP-EO) were obtained by hydrodistillation by a Clevenger-type apparatus whereas their chemical composition was analyzed by gas chromatography-flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Read More

    Brazilian legislation on genetic heritage harms Biodiversity Convention goals and threatens basic biology research and education.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1279-1284
    Departamento de Vertebrados, Museu Nacional/UFRJ, Quinta da Boa Vista, s/n, São Cristóvão, 20940-040 Rio de Janeiro, RJ, Brazil.

    Deacylative alkylation (DaA) of N-methyl-3-acetyl-2-oxindole for the synthesis of symmetrically 3,3-disubstituted 2-oxindoles. An access gate to anticancer agents and natural products.
    An Acad Bras Cienc 2018 ;90(1 Suppl 2):1089-1099
    Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Alicante, Spain.
    The synthesis of 3,3-disubstituted N-methyloxindoles, starting from 3-acetyl-2-hydroxy-1-methyloxindole employing a sequential one-pot synthesis, is studied. The process involves a first alkylation in the presence of 1 equiv. of both organic halide and Triton B and the second one employs another 1. Read More

    An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy.
    An Acad Bras Cienc 2018 ;90(1 Suppl 2):1101-1130
    Department of Chemistry and QOPNA, University of Aveiro, Aveiro, Portugal.
    Photodynamic therapy (PDT) is a modality of cancer treatment in which tumor cells are destroyed by reactive oxygen species (ROS) produced by photosensitizers following its activation with visible or near infrared light. The PDT success is dependent on different factors namely on the efficiency of the photosensitizer deliver and targeting ability. In this review a special attention will be given to the role of some drug delivery systems to improve the efficiency of tetrapyrrolic photosensitizers to this type of treatment. Read More

    Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients.
    An Acad Bras Cienc 2018 ;90(1 Suppl 2):1131-1174
    Department of Chemistry, Federal University of São Carlos, São Carlos, SP, Brazil.
    We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. Read More

    Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring.
    An Acad Bras Cienc 2018 ;90(1 Suppl 2):1035-1042
    Laboratorio de Investigación Ignacio Ribas, Departamento de Química Orgánica, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
    Herein, we describe our studies on the synthesis of 1α,25-dihydroxyvitamin D3 analogs possessing a benzene ring replacing the natural 5-membered D-ring by the Wittig-Horner and dienyne approaches. A key feature is the synthesis of a Cr(CO)3-complexed previtamin D derivative that enables the construction of vitamin D analogs with aromatic D-ring through a thermal [1,7]-H sigmatropic shift. This study establishes the basis for the design of new vitamin D analogs containing aromatic D-ring, complexed or uncomplexed to Cr(CO)3 type moieties for specific molecular recognition and drug research and development. Read More

    The Antifungal Activity of Naphthoquinones: An Integrative Review.
    An Acad Bras Cienc 2018 ;90(1 Suppl 2):1187-1214
    Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
    Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Read More

    Synthesis of Chiral 1,3-Dienes through Ring-Closing Metathesis of Enantioenriched Enynes: Potential Precursors of Morphane Analogs.
    An Acad Bras Cienc 2018 ;90(1 Suppl 2):1059-1072
    Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Alicante, Spain.
    A simple methodology for the synthesis of enynes by indium mediated diastereoselective allylation of aromatic N-tert-butanesulfinylimines bearing alkenyl groups at ortho-position with allyl bromide has been developed. The addition of the allyl indium intermediate to the chiral imine took place with excellent diastereoselectivity. Ruthenium-catalyzed ring-closing metathesis of the resulting enynes provided the expected cyclic 1,3-dienes in good to moderate yields. Read More

    Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones.
    An Acad Bras Cienc 2018 ;90(1 Suppl 2):1073-1088
    Laboratório de Avaliação e Síntese de Substâncias Bioativas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    N-acylhydrazone is an interesting privileged structure that has been used in the molecular design of a myriad of bioactive compounds. In order to identify new antinociceptive drug candidates, we described herein the design, synthesis, X-ray diffraction study and the pharmacological evaluation of a series of 3-amino-4-methylthiophene-2-acylcarbohydrazone derivatives (8a-t). Compounds were prepared in good overall yields through divergent synthesis from a common key intermediate and were characterized by classical spectroscopy methods. Read More

    Evaluation of meso-substituted cationic corroles as potential antibacterial agents.
    An Acad Bras Cienc 2018 ;90(1 Suppl 2):1175-1185
    Department of Chemistry, University of Aveiro, Aveiro, Portugal.
    Cationic derivatives of 5,10,15-tris[4-(pyridin-4-ylsulphanyl)-2,3,5,6-tetrafluorophenyl]-corrolategallium(III)pyridine and 5,10,15-tris[4-(pyridin-2-ylsulfanyl)-2,3,5,6-tetrafluorophenyl]-correlategallium(III)pyridine were synthesized and their photosensitizing properties against the naturally bioluminescent Gram-negative bacterium Allivibrio fischeri were evaluated. The cationic corrole derivatives exhibited antibacterial activity at micromolar concentrations against this Gram-negative bacterium strain. Read More

    Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives.
    An Acad Bras Cienc 2018 ;90(1 Suppl 2):1251-1271
    Departamento de Síntese de Fármacos, Instituto de Tecnologia em Fármacos Farmanguinhos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
    According to the World Health Organization, malaria remains one of the biggest public health problems in the world. The development of resistance is a current concern, mainly because the number of safe drugs for this disease is limited. Artemisinin-based combination therapy is recommended by the World Health Organization to prevent or delay the onset of resistance. Read More

    Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives.
    An Acad Bras Cienc 2018 ;90(1 Suppl 2):993-1026
    Department of Chemistry, University of Aveiro, Aveiro, Portugal.
    This review has two parts. The first one gives an approach to interdisciplinary studies against cancer carried out by many scientists using porphyrin-type substrates as photosensitizers in PDT. Intensive studies were performed for almost six decades. Read More

    A giant on the ground: another large-bodied Atractus (Serpentes: Dipsadinae) from Ecuadorian Andes, with comments on the dietary specializations of the goo-eaters snakes.
    An Acad Bras Cienc 2018 May 17. Epub 2018 May 17.
    Museo de Historia Natural, Instituto de Ciencias Biológicas, Escuela Politecnica Nacional, Quito, Ecuador.
    Body-size is significantly correlated with the number of vertebrae (pleomerism) in multiple vertebrate lineages, indicating that somitogenesis process is an important factor dictating evolutionary change associated to phyletic allometry and, consequently, species fitness and diversification. However, the role of the evolution of extreme body sizes (dwarfism and gigantism) remains elusive in snakes, mainly with respect to postnatal ontogeny in dietary preferences associated with evolution of gigantism in many lineages. We described herein a new species in the highly diversified and species-rich genus Atractus on the basis of four specimens from the southeastern slopes of the Ecuadorian Andes. Read More

    Morphology and morphometry of upland lakes over lateritic crust, Serra dos Carajás, southeastern Amazon region.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1309-1325. Epub 2018 May 17.
    Gerência de Meio Ambiente - Minas de Carajás, Departamento de Ferrosos Norte, Estrada Raymundo Mascarenhas, s/n, Mina de N4, 68516-000 Parauapebas, PA, Brazil.
    High-resolution satellite images, digital elevation models, bathymetric and sedimentological surveys coupled with statistical analysis were used to understand the physical environment and discuss their influence on water quality of the five upland lakes of Serra Sul dos Carajás, southeast Amazonia. The lakes have mid-altitude ranges (elevation), very small (catchment) and shallow to very shallow (central basins). Based on the length, area and volume, Violão and TI (Três Irmãs)-3 lakes may present large vertical movements of the water due to wind action and weakly stratified waters. Read More

    Insects galls of Pantanal areas in the State of Mato Grosso do Sul, Brazil: characterization and occurrence.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1543-1564. Epub 2018 May 17.
    Museu Nacional, Depto. Entomologia, Quinta da Boa Vista, s/n, São Cristóvão, 20940-040 Rio de Janeiro, RJ, Brazil.
    Two Pantanal areas were investigated in Corumbá, Mato Grosso do Sul. The field works were carried out in five trails, in August and December/2011 and April/2012. Seventy-six gall morphotypes were found in 52 host plants, 22 of them were identified at species level and 30 at genus. Read More

    Critical analyses when modeling tree biomass to ensure additivity of its components.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1759-1774. Epub 2018 May 17.
    Departamento de Ciências Florestais/ UFPR, Av. Pref. Lothário Meissner, 900, Jardim Botânico, Campus III, 80210-170 Curitiba, PR, Brazil.
    It is presented the theme additivity of biomass of tree components. To evaluate and discuss this context, experimental information collected in forests of Acacia mearnsii De Wild. was used. Read More

    Geomorphology-based unit hydrograph models for flood risk management: case study in Brazilian watersheds with contrasting physiographic characteristics.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1873-1890. Epub 2018 May 21.
    CDTec/Programa de Pós-Graduação em Recursos Hídricos, Universidade Federal de Pelotas/UFPel, Campus Porto, Rua Gomes Carneiro, 1, 96010-610 Pelotas, RS, Brazil.
    Heavy rainfall in conjunction with an increase in population and intensification of agricultural activities have resulted in countless problems related to flooding in watersheds. Among the techniques available for direct surface runoff (DSR) modeling and flood risk management are the Unit Hydrograph (UH) and Instantaneous Unit Hydrograph (IUH). This study focuses on the evaluation of predictive capability of two conceptual IUH models (Nash and Clark), considering their original (NIUH and CIUH) and geomorphological approaches (NIUHGEO and CIUHGEO), and their advantages over two traditional synthetics UH models - Triangular (TUH) and Dimensionless (DUH), to estimate DSR hydrographs taking as reference two Brazilian watersheds with contrasting geomorphological and climatic characteristics. Read More

    2,3,8-Trisubstituted Quinolines with Antimalarial Activity.
    An Acad Bras Cienc 2018 21;90(1 Suppl 2):1215-1231. Epub 2018 May 21.
    Instituto de Química, Universidade Estadual de Campinas, Campinas, SP, Brazil.
    Combination therapy drugs are considered a fundamental way to control malaria as it mimimizes the risk of emergence of resistance to the individual partner drugs. Consequently, this type of therapy constitutes a driving force for the discovery of new drugs with different modes of action, since this will provide options for combining different drugs to achieve the optimum antimalarial treatment. In this context, a 2,3,8-trisubstitued quinoline compound was found in a high throughput screen (HTS) to show an excellent inhibition of P. Read More

    New Palladacycle-Derived Acylhydrazones as Pre-catalysts in Mirozoki-Heck Coupling and Oxyarylations.
    An Acad Bras Cienc 2018 14;90(1 Suppl 2):1273-1278. Epub 2018 May 14.
    Laboratório de Química Bioorgânica, Instituto de Pesquisa de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Bl H, Ilha da Cidade Universitária, 21941-590 Rio de Janeiro, RJ, Brazil.
    New acylhydrazone-based palladacycles are prepared and evaluated as pre-catalysts in Mirozoki-Heck and oxyarylation reactions. Read More

    Recent Advances and Perspectives in Cancer Drug Design.
    An Acad Bras Cienc 2018 14;90(1 Suppl 2):1233-1250. Epub 2018 May 14.
    Laboratório de Química Medicinal e Computacional, Centro de Pesquisa e Inovação em Biodiversidade e Fármacos, Instituto de Física de São Carlos, Universidade de São Paulo, Av. João Dagnone, 1100, Jd. Santa Angelina, 13563-120 São Carlos, SP, Brazil.
    Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeutic area. Read More

    The exotic jumping snail Ovachlamys fulgens (Gude, 1900) (Gastropoda: Helicarionidae) in urban areas of the Upper-Paraná Atlantic Forest.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1591-1603. Epub 2018 May 14.
    Instituto de Biología Subtropical, Universidad Nacional de Misiones/CONICET, Rivadavia 2370, N3300LDX Posadas, Misiones, Argentina.
    The exotic land gastropod Ovachlamys fulgens (Gude, 1900), aka the jumping snail, was registered in Eldorado city, Misiones province, constituting the first documented record of that species in Argentina-and for all of South America as well. Identities of the individuals were confirmed through morphological examination, and by a DNA sequencing of the cytochrome oxidase subunit I gene. DNA sequences for the mitochondrial 16S-rRNA and the nuclear 18S-rRNA genes were also obtained from the morphologically-confirmed specimens to gain insights into the genetic background of this species in Argentina, and as additional markers for enhancing the rapidity of identification by governmental authorities who are responsible for managing the presence of exotic species. Read More

    Growth, Yield and Grain Nutritional Quality in Three Brazilian Pearl Millets (Pennisetum americanum L.) with African or Indian origins.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1749-1758. Epub 2018 May 14.
    Departamento de Fitotecnia/IA, Universidade Federal Rural do Rio de Janeiro, BR 465, Km 47, 23897-000 Seropédica, RJ, Brazil.
    In this study, we are presenting recommendations to the best agricultural use as well as for plant breeding of three millet cultivars namely ENA1 and ENA2, which have African origin, and BRS1501 originally from India. These cultivars were evaluated for growth, yield and grain quality traits. The morphological traits evaluated in this study indicated that the African genotypes ENA1 and ENA2 are better than the Indian genotype BRS1501 for no-till farming or to produce forage with 15% of crude protein at flowering and at harvest to produce stover (around 7% of crude protein content) for livestock feeding. Read More

    Influence of temperature and conductivity on the life-history characteristics of a pampean strain of Brachionus plicatilis.
    An Acad Bras Cienc 2018 Apr-Jun;90(2):1431-1444. Epub 2018 May 14.
    Instituto de Limnología Dr. Raúl A. Ringuelet/CCT-CONICET La Plata, FCNyM, UNLP, Boulevard 120 y 62, 1900 La Plata, Provincia de Buenos Aires, Argentina.
    In the present work, we provide the first approach about the life-history of Brachionus plicatilis in South America. We tested with laboratory experiments the response of the pampean strain of B. plicatilis for two of its main stressors (conductivity and temperature). Read More

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