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    New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies.
    G Ital Dermatol Venereol 2018 Jun;153(3):338-343
    International Hair Research Foundation, Milan, Italy -
    Background: Considering the importance of hair in our modern society and the impact of hair loss, the efforts of researchers are addressed to better understand the mechanisms behind the hair cycle regulation and dysregulation. Because hair loss is multifactorial, differenced and new approaches are required. In particular we addressed our attention to two recently identified targets in hair cycling and growth control: olfactory receptor and autophagy. Read More

    CME Part 1: Hair disorders in cancer patients.
    J Am Acad Dermatol 2018 Apr 13. Epub 2018 Apr 13.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:
    Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders (including alopecia, hirsutism, hypertrichosis, pigmentary and textural hair changes). The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy -induced alopecia has been well-documented mainly in the oncology literature, however the effect of other alterations such as radiation-induced alopecia, hirsutism, changes in hair color or texture on quality of life have not been described. Read More

    Cutaneous Adverse Reactions of Chemotherapy in Cancer Patients: A Clinicoepidemiological Study.
    Indian J Dermatol 2018 Jan-Feb;63(1):41-46
    Department of Dermatology, Venereology and Leprosy, S. P. Medical College, Bikaner, Rajasthan, India.
    Background: The diagnosis of cutaneous adversities in the cancer patient is especially difficult, given the complexity of their illness and combination protocols used for the treatment. The present study was undertaken to know the spectrum of cutaneous adversities in patients undergoing chemotherapy and the drug(s) most commonly associated with it.

    Materials And Methods: A total of 1000 patients with malignancies under chemotherapy in the oncology ward and outpatient department were screened in this observational study from January 2013 to February 2015. Read More

    Three Cases of Radiation-induced Temporary Alopecia with Hair Microscopic Examination: "Coudability Hair" Might Not be Specific for Alopecia Areata.
    Int J Trichology 2018 Jan-Feb;10(1):40-43
    Department of Dermatology, Busan Paik Hospital, Busan, Korea.
    Endovascular interventional procedures are widely used for the treatment of intracranial vascular lesions. However, they sometimes produce reversible alopecia, known as radiation-induced temporary alopecia, depending on the radiation dose. Radiation-induced temporary alopecia manifested as rectangular alopecic patches without signs of inflammation, reflects damage to the keratinocytes in the hair matrix of anagen hair follicles, due to the sensitivity of these cells to radiation. Read More

    Focal Atrichia: A Diagnostic Clue in Female Pattern Hair Loss.
    J Am Acad Dermatol 2017 Oct 7. Epub 2017 Oct 7.
    Duke University Medical Center, Durham, NC; Hair and Skin Research and Treatment Center, Dallas, Texas.
    Background: Focal atrichia is a common clinical finding in female pattern hair loss whose specificity and histologic findings need further clarification.

    Objective: To determine the frequency of focal atrichia in various types of hair loss and its histologic characteristics in female pattern hair loss.

    Methods: Part 1: Review of 250 consecutive female patients seen with hair loss for the presence of focal atrichia and Part 2: paired biopsies of haired areas vs focal atrichia in 18 subjects with female pattern hair loss RESULTS: Focal atrichia was seen in 46/104 (44%) of women with female pattern hair loss, including 67% of late onset vs 15% of early onset, compared to 3/146 (2%) of those with other hair disorders Biopsy findings of focal atrichia in female pattern hair loss showed primarily a more progressive miniaturization process than that of haired areas of the scalp. Read More

    Plica Polonica in a Patient on Chemotherapy: A Case Report with Review of Literature.
    Int J Trichology 2017 Jul-Sep;9(3):124-126
    Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.
    Plica polonica (plica neuropathica) is an uncommon entity characterized by irreversible twisting and matting of hair resulting in a hard impermeable mass of keratin. Although the exact mechanism is not fully understood, it has been attribute to longitudinal splitting or weathering of hair shaft due to vigorous friction and frequent use of harsh shampoos and harsh cleansers and/or due to keeping long hair with poor hair care or neglect, parasitic infection. We describe an unusual case of plica polonica occurring in a patient of lung adenocarcinoma on chemotherapy and review the literature. Read More

    Hair Loss: Common Causes and Treatment.
    Am Fam Physician 2017 Sep;96(6):371-378
    Washington Health Systems Family Medicine Residency, Washington, PA, USA.
    Hair loss is often distressing and can have a significant effect on the patient's quality of life. Patients may present to their family physician first with diffuse or patchy hair loss. Scarring alopecia is best evaluated by a dermatologist. Read More

    Presence of Mast Cells and Mast Cell Degranulation in Scalp Biopsies of Telogen Effluvium.
    Int J Trichology 2017 Jan-Mar;9(1):25-29
    Department of Dermatology, Saint Louis University, St. Louis, MO, USA.
    Background: Telogen effluvium (TE) is a type of acquired, diffuse alopecia that occurs due to an abnormal shift of scalp hair follicles from anagen to telogen, leading to premature shedding of hair. Previous studies have suggested the existence of a neuroimmunologic "brain-hair follicle" axis, in which mast cells have been implicated as an important link between the nervous system and immunologic system.

    Objective: The current study sought to investigate the role of mast cell presence and mast cell degranulation in the pathogenesis of TE. Read More

    Anagen Effluvium in Association With Extracorporeal Membrane Oxygenation.
    Pediatr Dermatol 2017 Jul 13;34(4):e201-e202. Epub 2017 Jun 13.
    Division of Dermatology, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia.
    Anagen effluvium (AE) is a type of alopecia with hair loss during the growth phase of a hair follicle and is most often associated with cytotoxic chemotherapy. This report describes a case of AE in a critically ill 2-year-old boy who developed cardiorespiratory failure requiring extracorporeal membranous oxygenation. We postulate that the combination of hypotension and hypoxia with subsequent reperfusion triggered an apoptotic cascade in the hair matrix, resulting in AE. Read More

    Permanent alopecia in patients with breast cancer after taxane chemotherapy and adjuvant hormonal therapy: Clinicopathologic findings in a cohort of 10 patients.
    J Am Acad Dermatol 2017 May 8;76(5):948-957. Epub 2017 Mar 8.
    St John's Institute of Dermatology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom; Department of Dermatopathology, St John's Institute of Dermatology, NHS Foundation Trust, Guy's and St Thomas' Hospital, London, United Kingdom. Electronic address:
    Background: Anagen effluvium with reversible scalp alopecia is a known side effect of chemotherapy. However, there are an increasing number of reports in the literature documenting permanent alopecia in patients treated with taxanes.

    Objective: We sought to describe the clinicopathologic features in breast cancer patients who underwent treatment with taxanes and adjuvant hormonal chemotherapy. Read More

    Hair pull test: Evidence-based update and revision of guidelines.
    J Am Acad Dermatol 2017 Mar 20;76(3):472-477. Epub 2016 Dec 20.
    Division of Dermatology, Ottawa Hospital, Ottawa, Ontario, Canada. Electronic address:
    Background: The hair pull test lacks validation and has unclear pretest guidelines.

    Objective: We sought to quantify normal hair pull test values and elucidate the effect of pretest hair washing and brushing. The impact of hair texture and lifestyle was also examined. Read More

    Pregnancy and the hair growth cycle: anagen induction against hair growth disruption using Nourkrin with Marilex , a proteoglycan replacement therapy.
    J Cosmet Dermatol 2017 Sep 23;16(3):421-427. Epub 2016 Sep 23.
    ETC Research and Development, Oslo, Norway.
    Postpartum effluvium is a well-known clinical fact. However, following some minor research activities in the 1960s, very little has happened on the research front of the subject. It was hypothesized that postpartum hair loss might be a manifestation of a change in the hair growth cycle occurring normally during pregnancy. Read More

    5-Bromo-2'-deoxyuridine induced effluvium via p53-mediated CD326-positive keratinocyte apoptosis in C57BL/6 mice.
    J Dermatol 2017 Feb 20;44(2):180-185. Epub 2016 Aug 20.
    Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang, Korea.
    Anagen effluvium develops because of disturbances in the hair follicle cycle, leading to acute and severe hair loss in humans. The objective of this study was to establish a mouse model of anagen effluvium by 5-bromo-2'-deoxyuridine (BrdU) treatment, and evaluate the pathological changes and underlying mechanisms. We treated 9-10-day-old pups and 3-7-week-old C57BL/6 mice with BrdU. Read More

    Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl.
    Acta Dermatovenerol Croat 2016 Jun;24(2):150-3
    Jana Zímová, MD. Department of Dermatology. University Hospital Ostrava. 17. listopadu 1790. 708 52 Ostrava - Poruba. Czech Republic;
    Trichotillomania (TTM) is defined by the Diagnostics and Statistic Manual of Mental Disorders, 4th edition (DMS-IV) as hair loss from a patient`s repetitive self-pulling of hair. The disorder is included under anxiety disorders because it shares some obsessive-compulsive features. Patients have the tendency towards feelings of unattractiveness, body dissatisfaction, and low self-esteem (1,2). Read More

    Anagen effluvium secondary to ingestion.
    Indian J Dermatol Venereol Leprol 2016 Nov-Dec;82(6):677-680
    Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
    Anagen effluvium, the shedding of anagen hair, leads to diffuse non-scarring alopecia. We report two cases of anagen effluvium in the same family secondary to the ingestion of tubers of Gloriosa superba, which contains the antimitotic alkaloid colchicine. Both patients developed anagen effluvium and gastroenteritis 1-2 weeks after consuming the tubers. Read More

    Bird's Nest View from a Dermatologist's Eye.
    Int J Trichology 2016 Jan-Mar;8(1):1-4
    Department of Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
    Plica neuropathica also known as "birds nest" is irreversible matting of hair seen in otherwise healthy individuals and is usually associated with use of ionic/herbal soaps, shampoos, parasitic infestations, psychiatric alterations, or neglect. Anagen effluvium is a known side effect of many immunosuppressive drugs. Rarely matting of hair has been reported following azathioprine. Read More

    Localized anagen effluvium and cataract development following an extended fluoroscopic interventional procedure.
    Dermatol Online J 2016 Nov 15;22(11). Epub 2016 Nov 15.
    School of Medicine, Oregon Health and Science University, Portland, OR.
    The skin and the eyes are prone to radiation-induced injury in fluoroscopic procedures. The degree of injury is related to various exposure and patient-related factors. We report a man who presented with an alopecic patch on the left occipital scalp following an extended fluoroscopically-guided endovascular procedure. Read More

    A Hospital-based Study to Determine Causes of Diffuse Hair Loss in Women.
    J Clin Diagn Res 2015 Aug 1;9(8):WC01-4. Epub 2015 Aug 1.
    Senior Resident, Department of Dermatology, Venereology and Leprosy, ESIC Medical College Kalaburagi, Karnataka, India .
    Background: Diffuse hair loss is a common complaint encountered by dermatologists in their daily clinical practice. Hair loss in women is a distressing condition. Various underlying factors individually or in combination contribute to the pathogenesis. Read More

    Alopecias due to drugs and other skin and systemic disorders.
    Curr Probl Dermatol 2015 20;47:97-106. Epub 2015 Feb 20.
    In this chapter, we will discuss the most common alopecias due to drugs and other skin and systemic disorders. The following hair disorders will be analyzed: telogen effluvium (acute and chronic); anagen effluvium; folliculotropic mycosis fungoides; and folliculitis due to bacteria, fungi, parasites, human immunodeficiency virus disease, lupus erythematosus, and sarcoidosis. We will cover topics including the epidemiology, etiology, clinical picture, and diagnosis of and current treatments for each disease. Read More

    Telogen elongation in the hair cycle of ob/ob mice.
    Biosci Biotechnol Biochem 2016 4;80(1):74-9. Epub 2015 Aug 4.
    a Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine , The University of Tokyo , Tokyo , Japan.
    Alopecia impairs the physical and mental health of patients. We have previously shown that 8-week-old ob/ob mice have no reactivity to depilation, which is a stimulus that induces anagen transition in normal mice, while no hair cycle abnormalities have been reported in other studies until mice reach 7 weeks of age. Therefore, we hypothesized that ob/ob mice have abnormalities in hair cycle progression beyond 7 weeks of age. Read More

    TrichoScan findings in patients with effluvium capillorum.
    Skinmed 2015 Mar-Apr;13(2):98-101
    Effluvium capillorum is a form of nonscarring alopecia characterized by diffuse hair shedding. This condition occurs when the normal balance of hairs in growth and rest phases is disrupted. Trichoscan is a computerized program used for digital measurement of hair growth and hair loss. Read More

    Anagen effluvium due to thallium poisoning derived from the intake of Chinese herbal medicine and rodenticide containing thallium salts.
    J Dermatol 2015 Oct 24;42(10):1027-9. Epub 2015 Jun 24.
    Department of Dermatology, Hospital del Mar-Parc de Salut Mar (Barcelona), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

    Trichoscopy findings in loose anagen hair syndrome: rectangular granular structures and solitary yellow dots.
    J Dermatol Case Rep 2015 Mar 31;9(1):1-5. Epub 2015 Mar 31.
    Department of Dermatology, Medical University of Warsaw, Poland;
    Background: Loose anagen hair syndrome (LAHS) is typically diagnosed in girls older than 2 years who present with hair that "will not grow". Hair microscopic examination shows absent inner and outer root sheaths, ruffling of the cuticle on the proximal hair shaft and deformed pigmented anagen bulbs.

    Objective: The aim of the study was to assess whether there are characteristic trichoscopic features favoring the diagnosis of LAHS. Read More

    Dystrophic-Anagen Effluvium Occurring During Pegylated Interferon-α-2a/Ribavirin Therapy.
    Hepat Mon 2015 Mar 20;15(3):e24804. Epub 2015 Mar 20.
    Department of Pathology, Ministry of Health Bagcilar State Hospital, Istanbul, Turkey.
    Introduction: Various types of dermatological manifestations have been reported due to hepatitis C virus (HCV) infection and anti-HCV therapy. Some of them have been described during IFN-based therapies. PEG-IFN-α-2a/RBV combination is used as the international standard of treatment for HCV infection for a long time. Read More

    [Your patient complains about hair loss. Contribution of a skin biopsy in noncicatricial alopecias].
    Rev Med Liege 2014 Dec;69(12):686-91
    The diagnosis of most alopecia problems is based on the clinical history and a well conducted clinical examination. The additional contributions of dermoscopy, trichoscopy and trichogram are helpful. However, a scalp biopsy is occasionally necessary to establish the correct diagnosis. Read More

    Recovery of Transplanted Eyebrow From Radiation-Induced Anagen Effluvium.
    J Cutan Med Surg 2015 Jul-Aug;19(4):400-3. Epub 2015 Mar 16.
    Department of Plastic and Reconstructive Surgery, Wellington Hospital, London, UK.
    Ablative surgery for skin cancer of the face can often leave patients with significant deformities. These disfigurements can include loss of hair in conspicuous areas such as the eyebrows, leaving the patients with unsightly facial asymmetry. Eyebrow transplantation serves to address this issue; however, it has often been discouraged in patients who are destined to receive radiotherapy to the cutaneous area in question. Read More

    Loss of normal anagen hair in pemphigus vulgaris.
    Clin Exp Dermatol 2015 Jul 16;40(5):485-8. Epub 2015 Feb 16.
    Autoimmune Bullous Diseases Research Center, Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Pemphigus vulgaris (PV) is a known cause of loss of 'normal' anagen hair; that is, shedding of intact anagen hairs covered by root sheaths. However, studies on this subject are limited.

    Aim: To investigate anagen hair shedding in patients with PV, and ascertain its association with disease severity. Read More

    Is TrichoScan a new diagnostic method for diffuse hair loss?
    Turk J Med Sci 2014 ;44(3):432-8
    Department of Dermatology, Yüzüncü Yıl University, Van, Turkey.
    Aim: In this study, we investigated the sensitivity of TrichoScan, a computer-based phototrichogram, in the evaluation of diffuse hair loss in women and the relationship between iron deficiency anemia and hair loss.

    Materials And Methods: We recruited 100 female patients with diffuse hair loss. In all of the patients, a 1-cm2 area of hair located in a temporoparietal region was shortened to 0. Read More

    Radiation-induced temporary alopecia after embolization of cerebral aneurysm.
    Indian J Dermatol 2014 Nov;59(6):633
    Department of Dermatology, PSG Hospitals, Peelamedu, Coimbatore, Tamil Nadu, India.
    A 47-year-old Indian woman with dark hair developed dramatic alopecia of the occipito-vertical area two weeks after a fluoroscopically-guided endovascular procedure for treatment of cerebral aneurysm. There was spontaneous repopulation of hair in 14 weeks. Neuro-radiological intervention procedures are becoming commoner by the day in India, and the rare but documented possibility of such reactions occurring in patients should be kept in mind by the treating surgeon as well as dermatologist. Read More

    Chronic telogen effluvium and female pattern hair loss are separate and distinct forms of alopecia: a histomorphometric and immunohistochemical analysis.
    Clin Exp Dermatol 2014 Dec 22;39(8):868-73. Epub 2014 Aug 22.
    Department of Pathology, Unicamp, Campinas, São Paulo, Brazil.
    Background: Chronic telogen effluvium (CTE), a poorly understood condition, can be confused with or may be a prodrome to female pattern hair loss (FPHL). The pathogenesis of both is related to follicle cycle shortening and possibly to blood supply changes.

    Aim: To analyze a number of histomorphometric and immunohistochemical findings through vascular endothelial growth factor (VEGF), Ki-67, and CD31 immunostaining in scalp biopsies of 20 patients with CTE, 17 patients with mild FPHL and 9 controls. Read More

    Hair disorders associated with autoimmune connective tissue diseases.
    G Ital Dermatol Venereol 2014 Oct 30;149(5):555-65. Epub 2014 Jun 30.
    Dermatology and Venereology Private Practice Bari and Barletta, Italy -
    Hair disorders are frequently observed in various systemic diseases, including autoimmune connective tissue diseases (CTDs), with predilection of lupus erythematosus (LE), followed by dermatomyositis (DM) and scleroderma. Hair disorders in CTDs may manifest as various clinical patterns, such as telogen hair loss, diffuse thinning or fragility of hair, and scarring alopecia. Less common hair disorders include anagen effluvium, alopecia areata, and trichomegaly. Read More

    Analysis of quantitative changes in hair growth during treatment with chemotherapy or tamoxifen in patients with breast cancer: a cohort study.
    Br J Dermatol 2014 Mar;170(3):643-50
    Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité - Universitätsmedizin Berlin, Berlin, Germany.
    Background: In women with breast cancer, chemotherapy-induced alopecia is a highly feared but common side-effect of antineoplastic treatment. The onset, pattern and amount of hair loss differ depending on the therapy regimen and have not yet been quantified using standardized techniques.

    Objectives: To evaluate objectively and compare the effect of antineoplastic therapy with chemotherapy or tamoxifen on hair loss, quantifying trichological parameters. Read More

    Diagnosis and management of alopecia in children.
    Pediatr Clin North Am 2014 Apr 21;61(2):427-42. Epub 2014 Jan 21.
    Section of Dermatology, Department of Pediatrics, The Children's Hospital of Philadelphia, 3550 Market Street, 2nd Floor Dermatology, Philadelphia, PA 19104, USA. Electronic address:
    Alopecia in childhood is a source of high concern, frustration, and anxiety. Delineating types of alopecia and those that are chronic or potentially related to underlying medical problems is important. There are 5 common types of hair loss in children: alopecia related to tinea capitis, alopecia areata spectrum/autoimmune alopecia, traction alopecia, telogen effluvium, and trichotillomania/trichotillosis. Read More

    Evaluation of biophysical skin parameters and assessment of hair growth in patients with acne treated with isotretinoin.
    Postepy Dermatol Alergol 2013 Dec 18;30(6):343-9. Epub 2013 Dec 18.
    Department of General, Esthetic Dermatology and Dermatosurgery, Medical University of Lodz, Poland. Head: Prof. Grażyna Broniarczyk-Dyła MD, PhD.
    Introduction: Treatment of the severe forms of acne vulgaris remains a challenge. Isotretinoin is a drug often used in these cases. Retinoids affect the mechanisms that play a role in the pathogenesis of acne, reduce the production of sebum and sizes of the sebaceous glands. Read More

    Noninflammatory, nonpruritic alopecia of horses.
    Vet Clin North Am Equine Pract 2013 Dec 10;29(3):629-41. Epub 2013 Oct 10.
    Department of Clinical Sciences, Colorado State University, 300 West Drake, Fort Collins, CO 80523, USA. Electronic address:
    Noninflammatory, nonpruritic alopecias are uncommonly encountered in the horse. Alopecia areata, an apparently autoimmune hair follicle bulbitis produces focal, multifocal to widespread hair loss. The skin is otherwise normal. Read More

    Anagen effluvium.
    Indian J Dermatol Venereol Leprol 2013 Sep-Oct;79(5):604-12
    Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Disturbances of hair follicle cycling lie at the heart of most hair growth disorders, and have dramatic effects on visible hair growth and shedding. The two common disorders due to aberration in hair follicle cycling are telogen and anagen effluvium. Though a lot of literature addresses the problem of telogen effluvium, there are not many reviews on anagen effluvium or anagen hair loss. Read More

    The changes in the hair cycle during gestation and the post-partum period.
    J Eur Acad Dermatol Venereol 2014 Jul 20;28(7):878-81. Epub 2013 May 20.
    Department of Dermatology, Haydarpasa Numune Research and Training Hospital, Istanbul, Turkey.
    Background: In pregnancy, increased numbers of hair follicles remain in the anagen phase for longer periods due to hormonal changes and return to the telogen phase within 3-6 months of delivery with a sudden drop in hormone levels. This results in excessive shedding of hair known as post-partum telogen effluvium.

    Objective: To determine the changes in the hair cycle during gestation and the post-partum period. Read More

    [Acquired alopecia in childhood].
    Hautarzt 2013 May;64(5):371-9; quiz 380-1
    Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
    Hair loss and alopecia occur frequently in children. The prevalence of the underlying causes and conditions, treatment options and prognosis differ in part significantly from adulthood. This article focuses on frequent forms of acquired alopecia which are not associated with inflammation or scarring of the scalp. Read More

    Follicular density and ratios in scarring and nonscarring alopecia.
    Am J Dermatopathol 2013 Dec;35(8):818-26
    *Department of Pathology, The Dermatology Group, Verona, New Jersey †New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey.
    Follicular counts from transverse sectioning of scalp biopsies have not been statistically scrutinized across disease entities in a standardized fashion. We applied uniform histological criteria and strict statistical measures to compare nonscarring and scarring alopecia. We studied 700 consecutive cases including 355 nonscarring alopecia [136 telogen effluvium, 115 alopecia areata (AA), 95 androgenetic alopecia, and 9 trichotillosis] and 345 scarring alopecia [238 central centrifugal cicatricial alopecia, 29 traction alopecia, 26 lichen planopilaris, 21 end-stage alopecia, 20 lupus erythematosus, 11 folliculitis decalvans]. Read More

    Dopamine is a novel, direct inducer of catagen in human scalp hair follicles in vitro.
    Br J Dermatol 2013 Mar 12;168(3):520-5. Epub 2012 Dec 12.
    Dermatology Research Centre, Salford Royal Hospital, The University of Manchester, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, Manchester, UK.
    Background: Although there are clinical reports of hair loss associated with levodopa and dopamine agonists, it is unclear whether dopamine exerts any direct effects on the human hair follicle (HF).

    Objectives: Given the widespread use of dopamine agonists and antagonists in clinical medicine, we sought to determine whether dopamine exerts direct effects on human HF growth and/or pigmentation in vitro, and whether human HFs express dopamine receptors (DRs).

    Methods: Microdissected human scalp HFs from women were treated in serum-free organ culture for 7 days with dopamine (10-1000 nmol L ), and the effects on hair shaft production, HF cycling (i. Read More

    Drugs and hair loss.
    Dermatol Clin 2013 Jan 18;31(1):67-73. Epub 2012 Sep 18.
    Department of Medicine, St. Vincent's Hospital, University of Melbourne, Aikenhead Wing, 41 Victoria Parade, Fitzroy, Melbourne, Victoria 3065, Australia.
    Hair loss is a common complaint, both in men and women, and use of prescription medications is widespread. When there is a temporal association between the onset of hair loss and commencement of a medication, the medication is commonly thought to have caused the hair loss. However, hair loss and in particular telogen effluvium may occur in response to a number of triggers including fever, hemorrhage, severe illness, stress, and childbirth, and a thorough exclusion of these potential confounders is necessary before the hair loss can be blamed on the medication. Read More

    Alopecia associated with strontium ranelate use in a 62-year-old woman.
    Osteoporos Int 2013 Mar 12;24(3):1127-9. Epub 2012 Apr 12.
    Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taiwan, Republic of China.
    Strontium ranelate is an effective drug that was developed for treating osteoporosis. Here, we report the case of a 62-year-old woman who developed headache and diffuse scalp hair loss 1 week after receiving strontium ranelate treatment for osteoporosis. The treatment was subsequently stopped because of the intractable headache. Read More

    [Methods of hair loss evaluation in patients with endocrine disorders].
    Endokrynol Pol 2011 ;62 Suppl 1:29-34
    Klinika Dermatologii, Warszawski Uniwersytet Medyczny, Warszawa.
    Hair loss may accompany several endocrine disorders, including hypopituitarism, hypothyreosis, hyperthyreosis, hypoparathyroidism, diabetes mellitus, growth hormone deficiency, hyperprolactinaemia, polycystic ovary syndrome, SAHA syndrome, congenital adrenal hyperplasia, Cushing syndrome, or virilising tumours. Most patients with endocrine disorders present with diffuse non-scarring alopecia, such as anagen effluvium, telogen effluvium or androgenetic alopecia. Focal non-scarring alopecia, such as alopecia areata coexisting with autoimmune thyroiditis, is less frequent and scarring alopecia is a rare finding in patients with endocrine abnormalities. Read More

    Skin manifestations associated with chemotherapy in children with hematologic malignancies.
    Pediatr Dermatol 2012 May-Jun;29(3):264-9. Epub 2011 Nov 2.
    Department of Dermatology, Hospital Universitario Dr. Jose E. Gonzalez, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
    Chemotherapy used in the treatment of malignancies produces multiple mucocutaneous adverse reactions that may be clinically challenging. These mucocutaneous reactions are common and sometimes not diagnosed. The objective of this study was to determine the clinical patterns of the mucocutaneous manifestations during and after chemotherapy in children with a hematologic malignancy and to determine whether nutritional status influences the clinical presentation. Read More

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