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Skin Appendage Disord 2021 Apr 18;7(3):224-226. Epub 2021 Feb 18.

Division of Dermatology, Department of Internal Medicine, Hospital of the clinics of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Radiotherapy-induced alopecia is characterized by an anagen effluvium (AE). It may be temporary or permanent, depending on the radiation dose. The diagnosis is based on clinical history and dermatologic exam with trichoscopy being auxiliary the presence of flame hair. Read More

Sci Rep 2021 May 27;11(1):11189. Epub 2021 May 27.

Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, 912, Taiwan, ROC.

Since 2013, a high incidence of bilateral symmetrical alopecia has been observed in free-ranging Formosan macaques (Macaca cyclopis) in Mt. Longevity, Taiwan. We hypothesized that stress induces alopecia in this population. Read More

Ann Dermatol 2020 Apr 11;32(2):141-145. Epub 2020 Mar 11.

Department of Dermatology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Background: Telogen effluvium (TE) is characterized by massive hair shedding and results from an abrupt conversion of anagen to telogen. Differentiation of TE with other hair disorders showing massive hair shedding is difficult.

Objective: To evaluate the morphologic characteristics of pulled out hair of TE. Read More

Ital J Dermatol Venerol 2021 Apr 21. Epub 2021 Apr 21.

Sacred Heart Catholic University, Rome, Italy.

Background: Androgenetic alopecia (AGA) is the most frequent form of alopecia. Telogen effluvium (TE) is a common form of diffuse hair loss mainly observed in women. The aim of our study was to evaluate the efficacy of a topical trichological treatment containing a new combination of molecules for the treatment of AGA and TE. Read More

Clin Cosmet Investig Dermatol 2021 30;14:333-347. Epub 2021 Mar 30.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Lupus erythematosus (LE) is a chronic autoimmune condition with a wide spectrum of clinical presentations. Alopecias, both non-scarring and scarring, frequently occur in the context of LE and can assume several different patterns. Furthermore, alopecia occurring with LE may be considered LE-specific if LE-specific features are present on histology; otherwise, alopecia is considered non-LE-specific. Read More

J Eur Acad Dermatol Venereol 2021 Mar 3. Epub 2021 Mar 3.

Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Topical minoxidil has been used for many years as treatment for different hair disorders. Even though it is an effective therapy, many patients show poor compliance due to the cosmesis, cost and side-effects. During the last few years, low-dose oral minoxidil has proven to be an alternative for patients with alopecia. Read More

Clin Breast Cancer 2021 Jan 23. Epub 2021 Jan 23.

Department of Medical Oncology, Regional Cancer Center, Thiruvananthapuram, Kerala, India.

Background: Systemic chemotherapy and targeted agents are associated with various cutaneous toxicities. Even though cutaneous toxicities are manageable, it often results in treatment discontinuation and worsens the patients' quality of life.

Aim: The study aimed to determine the spectrum of cutaneous toxicities in patients receiving systemic chemotherapy and targeted agents for breast cancer patients. Read More

Dermatol Ther 2021 03 7;34(2):e14799. Epub 2021 Feb 7.

Department of Dermatology, University Medical Center Mainz, Mainz, Germany.

Androgenetic alopecia (AGA) with its precursor miniaturization of anagen phase (MA) and telogen effluvium (TE) represent nonscarring hair loss diseases which causes moderate to severe aesthetic and psychologic discomfort in affected people. Several therapeutic approaches have been tested through the latest decades, with different degree of success. In this study we aim to analyze the efficacy and outcome of an innovative therapeutic protocol, named TRICHOBIOLIGHT, a combination of active principles conveyed by mesotherapy directly on the scalp with a subsequent photobiostimulation session with LED light (630 nm). Read More

Exp Dermatol 2021 02 28;30(2):288-290. Epub 2020 Dec 28.

Department of Dermatology, Universidade Federal Fluminense, Centro de Ciências Médicas, Hospital Universitário Antonia Pedro, Niterói - Rio de Janeiro, Brazil.

The novel viral pandemic coronavirus disease 2019 (COVID-19) has sparked uncertainties as to its origin, epidemiology and natural course. The study of the cutaneous manifestations of COVID-19 has evolved with the hope that they may be useful as markers for the disease, prognostication and pathogenic insights into the disease. With regard to the hair, clinicopathological correlations have remained elusive. Read More

Dermatol Ther 2021 Jan 23;34(1):e14547. Epub 2020 Nov 23.

Department of Clinical and Molecular Sciences - Dermatological Clinic, Università Politecnica delle Marche, Ancona, Italy.

Telogen effluvium (TE) is one of the most common form of hair loss in women. Many triggers have been identified, as stress, drugs, trauma, endocrine disease, nutritional deficiencies, and febrile states. We report three cases of TE occurred after severe Sars-Cov-2 infection and provide our clinical management, according to Sars-Cov-2 hygiene measures. Read More

Pediatr Dermatol 2021 Jan 12;38(1):58-65. Epub 2020 Nov 12.

Dermatology Department, Şişli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, İstanbul, Turkey.

Background/objectives: Oncology patients present with various skin manifestations related to primary disease and treatments. Although these skin toxicities are well described in adults, studies of pediatric oncology patients are limited. The objective of this study was to evaluate the cutaneous findings in pediatric oncology patients receiving chemotherapy. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):161-163

Department of Dermatology and Venereology, University of Health Sciences, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.

Albendazole is a drug commonly used for treating many parasitoses. The primary mechanism of action is inhibition of microtubule polymerization binding to β-tubulin, similar to colchicine as a microtubule formation inhibitor. It is reasonable that these two antimitotic drugs can cause side effects such as alopecia and cytopenia by a similar mechanism. Read More

Int J Trichology 2020 Mar-Apr;12(2):93-96. Epub 2020 May 5.

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

Low-dose methotrexate (MTX) is the backbone of treatment for extensive psoriasis vulgaris not responding to topical therapy. Since its induction for the treatment of psoriasis in the 1970, its short- and long-term side effect profile has been extensively studied. Hair loss with MTX has been reported mostly with high-dose MTX used in chemotherapy. Read More

J Cosmet Dermatol 2021 Mar 29;20(3):784-791. Epub 2020 Jul 29.

Monasterium Laboratory, Skin and Hair Research Solutions GmbH, Muenster, Germany.

Background: Human hair follicles (HFs) express the olfactory receptor (OR)2AT4, which is selectively stimulated by the synthetic sandalwood-like odorant, Sandalore . In organ-cultured, human scalp HFs, Sandalore prolongs anagen and suppresses apoptosis by up-regulating intrafollicular IGF-1 mediated signaling.

Aims: The objective of this study is to demonstrate whether effects of Sandalore observed ex vivo translate into a clinically relevant effect in patients with telogen effluvium. Read More

J Dermatolog Treat 2020 Jul 16:1-2. Epub 2020 Jul 16.

Department of Dermatology and Venereology, Specialist Dermatologist at Baghdad Teaching Hospital, Baghdad, Iraq.

New COVID-19 skin manifestations continue to be described. We present a patient with COVID-19 related anagen effluvium. The patient was treated with and responded to low dose systemic steroids to treat an accompanying extensive COVID-19-related urticaria and maculopapular rash. Read More

J Am Acad Dermatol 2021 Mar 2;84(3):737-746. Epub 2020 Jul 2.

Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida. Electronic address:

Background: Although topical minoxidil is an effective treatment option for hair loss, many patients are poorly compliant because of the necessity to apply the medication twice a day, undesirable hair texture, and scalp irritation.

Objective: In recent years, oral minoxidil at low dose has been proposed as a safe alternative. This study reviewed articles in which oral minoxidil was used to treat hair loss to determine its efficacy and safety as an alternative to topical minoxidil. Read More

Dermatol Res Pract 2020 5;2020:8125081. Epub 2020 May 5.

Moscow Scientific and Practical Centre of Clinical and Aesthetic Dermatology and Venerology, Moscow City Health Department, Moscow, Russia.

Follicular proteoglycans are key players with structural, functional, and regulatory roles in the growth and cycling behaviour of the hair follicles. The expression pattern of specific proteoglycans is strongly correlated with follicular phase transitions, which further affirms their functional involvement. Research shows that bioactive proteoglycans, e. Read More

Dermatol Ther 2020 05 20;33(3):e13293. Epub 2020 Mar 20.

Hypera Pharma, São Paulo, SP, Brazil.

Androgenetic alopecia (AGA) and telogen effluvium (TE) are common causes of hair loss, with limited options for treatment. The aim of this study was to determine the efficacy and safety of a new formulation kit (Pielus Anti-hair loss lotion and shampoo) containing anti-inflammatory and antioxidant agents in patients with TE and/or AGA. This was a prospective, single-arm, open-label study with 35 women and 10 men, median age of 44 years, with clinical diagnosis of TE and/or AGA. Read More

JAAD Case Rep 2020 Jan 26;6(1):54-56. Epub 2019 Dec 26.

Division of Dermatology, Department of Internal Medicine, Albert Einstein College of Medicine, Bronx, New York.

BMC Vet Res 2019 Nov 15;15(1):411. Epub 2019 Nov 15.

Institute of Veterinary Pathology at the Centre for Clinical Veterinary Medicine, Veterinary Faculty, Ludwig-Maximilians-Universität München, Veterinärstr. 13, 80539, Munich, Germany.

Background: Alopecia is defined as the partial or complete absence of hair from areas of the body where it normally grows. Alopecia secondary to an infectious disease or parasitic infestation is commonly seen in cattle. It can also have metabolic causes, for example in newborn calves after a disease event such as diarrhoea. Read More

Dermatol Ther 2020 01 25;33(1):e13168. Epub 2019 Nov 25.

Central Michigan University College of Medicine, Saginaw, Michigan.

Medical conditions involving hair are typically managed by a dermatologist. However, a significant psychosocial association has been found both in the development of hair conditions through primary pathologic involvement and as secondary comorbidity. Trichopsychodermatology is an emerging field aiming to better understand the psychiatric and psychosocial impacts of disorders involving hair. Read More

Clin Cosmet Investig Dermatol 2019 8;12:745-750. Epub 2019 Oct 8.

Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Menoufiya Governorate, Egypt.

Background: Telogen effluvium (TE) is a form of alopecia characterized by diffuse hair shedding. Vitamin D receptor (VDR) plays a role in hair cycle regulation as it is expressed in follicular keratinocytes and dermal papilla cells.

Purpose: To investigate the association between Cdx1 and Taq1 VDR gene polymorphisms and chronic TE. Read More

Indian J Plast Surg 2019 May 26;52(2):209-215. Epub 2019 Sep 26.

Rejuvenate Plastic, Cosmetic and Hair Transplant Centre, Indore, Madhya Pradesh, India.

 There is a time lag between hair follicle harvesting and implantation, during this time hair follicles suffer ischemic injury. We need a holding medium or a solution to minimize or neutralize ischemic injury.  To evaluate plasma as a graft holding solution in terms of its efficacy in hair growth and hair graft survival. Read More

J Cutan Aesthet Surg 2019 Apr-Jun;12(2):118-123

DermaClinix-The Complete Skin and Hair Solution Center, Delhi, India.

Background: The use of non-scalp donor hair is considered in situations of a relative or absolute lack of head donor hair supply. Till now, very few published works are present on body hair transplant. None of them have compared scalp and non-scalp hair in terms of survival as well as characteristics. Read More

Int J Trichology 2019 May-Jun;11(3):107-112

Derma Skin Cosmetic and Laser Clinic, Nagpur, Maharashtra, India.

Alopecia, a frequently reported problem, severely impacts the quality of life of patients and is often associated with loss of confidence and low self-esteem. Several conditions such as telogen effluvium (TE), anagen effluvium, diffuse type of alopecia areata, female pattern hair loss, hair shaft abnormalities, loose anagen hair syndrome, and congenital atrichia or hypotrichosis are associated with hair loss. The actual prevalence rate of TE is not reported since most cases are subclinical in nature. Read More

J Cosmet Dermatol 2020 Feb 28;19(2):485-493. Epub 2019 May 28.

Robertet Group, Grasse, France.

Background: Miliacin, the main triterpenoid from millet, is known to stimulate keratinocyte metabolism and proliferation. Polar lipids are able to form vesicles with active compounds and to improve their bioavailability.

Objectives: We aimed to demonstrate potential benefits of a solution of miliacin encapsulated within polar lipids (MePL) on telogen effluvium prevention and hair condition in women. Read More

Medicine (Baltimore) 2019 Mar;98(12):e14938

Biophotonics Applied to Health Sciences Postgraduation Program, Universidade Nove de Julho, Universidade Nove de Julho.

The female hair loss pattern was originally described as a synonym for androgenetic alopecia. It has been defined as progressive miniaturizations of the hair follicles, with a great impact on the quality of life of affected patients, causing significant psychosocial limitations. It was recently proven that photobiomodulation is a safe and effective way to treat the different types of hair loss. Read More

Pol Merkur Lekarski 2019 Feb;46(272):77-79

Department of Dermatology, University Hospital in Cracow, Poland.

Hair loss is a significant and constantly growing social problem among both women and men. Many drugs through their toxic effects on the cells of the hair follicle matrix have an influence on mitotic divisions and the hair growth cycle, leading to anagen or telogen effluvium. Currently, there are more and more publications and clinical studies evaluating the possibility of using methotrexate in the treatment of various types of non-scarring and scarring alopecia, but there is no study of the effect relating to the hair loss with low doses of the drug in other therapeutic indications. Read More

J Cutan Aesthet Surg 2020 Jan-Mar;13(1):50-56

Diplomate of American Board of hair Restoration, Rejuvenate hair transplant centre, Indore, India.

Background: There is a time lag between hair follicle harvesting and implantation; during this time, hair follicles have ischemic injury. We need a holding media or a solution to minimize or neutralize ischemic injury.

Aim And Objectives: The aim of this study was to evaluate plasma as a graft-holding solution in terms of its efficacy in hair growth and hair graft survival. Read More

J Cutan Aesthet Surg 2020 Jan-Mar;13(1):31-34

Department of Dermatology, Ginzburg Hair Clinic, Ra'anana, Israel.

Follicular unit extraction (FUE) is a popular hair transplant technique, which involves extraction of follicular grafts from the donor area, usually occipital area of scalp. We have described few cases where non-scarring alopecia patches appeared at donor area similar to that of alopecia areata clinically, after 2-3 weeks of surgery. Even trichoscopically, findings were similar to alopecia areata showing exclamation marks, black dots. Read More