825 results match your criteria Anaesthesia and Intensive Care Medicine [Journal]


Correction to: A decade of progress in critical care echocardiography: a narrative review.

Intensive Care Med 2019 Apr 15. Epub 2019 Apr 15.

Consultant in Cardiothoracic Critical Care, St Georges Hospital, St Georges University of London, London, UK.

The original version of this article unfortunately contained a mistake. Read More

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http://dx.doi.org/10.1007/s00134-019-05616-yDOI Listing

Reverse triggering with breath stacking during mechanical ventilation results in large tidal volumes and transpulmonary pressure swings.

Intensive Care Med 2019 Mar 28. Epub 2019 Mar 28.

Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s00134-019-05608-yDOI Listing
March 2019
1 Read

A decade of progress in critical care echocardiography: a narrative review.

Intensive Care Med 2019 Mar 25. Epub 2019 Mar 25.

Consultant in Cardiothoracic Critical Care, St Georges Hospital, St Georges University of London, London, UK.

Introduction: This narrative review focusing on critical care echocardiography (CCE) has been written by a group of experts in the field, with the aim of outlining the state of the art in CCE in the 10 years after its official recognition and definition.

Results: In the last 10 years, CCE has become an essential branch of critical care ultrasonography and has gained general acceptance. Its use, both as a diagnostic tool and for hemodynamic monitoring, has increased markedly, influencing contemporary cardiorespiratory management. Read More

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http://link.springer.com/10.1007/s00134-019-05604-2
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http://dx.doi.org/10.1007/s00134-019-05604-2DOI Listing
March 2019
6 Reads

Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients.

Intensive Care Med 2019 Mar 25. Epub 2019 Mar 25.

Transplant Infectious Diseases Unit, University Hospitals Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.

Purpose: Prognosis of solid organ transplant (SOT) recipients has improved, mainly because of better prevention of rejection by immunosuppressive therapies. However, SOT recipients are highly susceptible to conventional and opportunistic infections, which represent a major cause of morbidity, graft dysfunction and mortality.

Methods: Narrative review. Read More

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http://dx.doi.org/10.1007/s00134-019-05597-yDOI Listing
March 2019
2 Reads

High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis.

Intensive Care Med 2019 Mar 19. Epub 2019 Mar 19.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

Background: This systematic review and meta-analysis summarizes the safety and efficacy of high flow nasal cannula (HFNC) in patients with acute hypoxemic respiratory failure.

Methods: We performed a comprehensive search of MEDLINE, EMBASE, and Web of Science. We identified randomized controlled trials that compared HFNC to conventional oxygen therapy. Read More

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http://dx.doi.org/10.1007/s00134-019-05590-5DOI Listing
March 2019
1 Read

Nasal high-flow preoxygenation for endotracheal intubation in the critically ill patient? Maybe.

Intensive Care Med 2019 Apr 19;45(4):532-534. Epub 2019 Mar 19.

Department of Anaesthesia and Intensive Care, Saint Eloi Montpellier University Hospital, and PhyMedExp, University of Montpellier, INSERM, CNRS, 80, avenue Augustin Fliche, 34295, Montpellier Cedex 5, France.

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http://dx.doi.org/10.1007/s00134-019-05598-xDOI Listing

Obesity in the critically ill: a narrative review.

Intensive Care Med 2019 Mar 19. Epub 2019 Mar 19.

Anesthesia and Critical Care Department (DAR-B), Saint Eloi, University of Montpellier, Research Unit: PhyMedExp, INSERM U-1046, CNRS, 34295, Montpellier Cedex 5, France.

The World Health Organization defines overweight and obesity as the condition where excess or abnormal fat accumulation increases risks to health. The prevalence of obesity is increasing worldwide and is around 20% in ICU patients. Adipose tissue is highly metabolically active, and especially visceral adipose tissue has a deleterious adipocyte secretory profile resulting in insulin resistance and a chronic low-grade inflammatory and procoagulant state. Read More

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http://link.springer.com/10.1007/s00134-019-05594-1
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http://dx.doi.org/10.1007/s00134-019-05594-1DOI Listing
March 2019
17 Reads

Pantoprazole prophylaxis in ICU patients with high severity of disease: a post hoc analysis of the placebo-controlled SUP-ICU trial.

Intensive Care Med 2019 Mar 12. Epub 2019 Mar 12.

Department of Intensive Care 4131, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Purpose: In the subgroup of patients with Simplified Acute Physiology Score (SAPS) II > 53 in the Stress Ulcer Prophylaxis in Intensive Care Unit (SUP-ICU) trial, there was interaction (P = 0.049) suggesting increased mortality in patients allocated to pantoprazole as compared with placebo. We aimed to explore this further. Read More

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http://link.springer.com/10.1007/s00134-019-05589-y
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http://dx.doi.org/10.1007/s00134-019-05589-yDOI Listing
March 2019
8 Reads

Variability in functional outcome and treatment practices by treatment center after out-of-hospital cardiac arrest: analysis of International Cardiac Arrest Registry.

Intensive Care Med 2019 Mar 8. Epub 2019 Mar 8.

Department of Neurology, Columbia-Presbyterian Medical Center, New York, NY, USA.

Purpose: Functional outcomes vary between centers after out-of-hospital cardiac arrest (OHCA) and are partially explained by pre-existing health status and arrest characteristics, while the effects of in-hospital treatments on functional outcome are less understood. We examined variation in functional outcomes by center after adjusting for patient- and arrest-specific characteristics and evaluated how in-hospital management differs between high- and low-performing centers.

Methods: Analysis of observational registry data within the International Cardiac Arrest Registry was used to perform a hierarchical model of center-specific risk standardized rates for good outcome, adjusted for demographics, pre-existing functional status, and arrest-related factors with treatment center as a random effect variable. Read More

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http://dx.doi.org/10.1007/s00134-019-05580-7DOI Listing
March 2019
2 Reads

Cerebral oximetry in cardiac arrest: a potential role but with limitations.

Intensive Care Med 2019 Mar 6. Epub 2019 Mar 6.

Department of Anaesthesia, Royal United Hospital, Bath, UK.

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http://dx.doi.org/10.1007/s00134-019-05572-7DOI Listing

Global paediatric critical care research: mind the gaps.

Intensive Care Med 2019 Mar 6. Epub 2019 Mar 6.

Respiratory, Critical Care and Anaesthesia Unit, University College London Great Ormond Street, Institute of Child Health, London, UK.

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http://dx.doi.org/10.1007/s00134-019-05571-8DOI Listing

Should we always use the peripheral cannula for distal leg reperfusion in femoro-femoral ECMO patients?

Intensive Care Med 2019 Apr 6;45(4):559-560. Epub 2019 Mar 6.

Cardiac Surgery Department, Pitié-Salpétrière Hospital, Paris, France.

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http://dx.doi.org/10.1007/s00134-019-05531-2DOI Listing
April 2019
7.214 Impact Factor

Management of donation after brain death (DBD) in the ICU: the potential donor is identified, what's next?

Intensive Care Med 2019 Mar 28;45(3):322-330. Epub 2019 Feb 28.

Brazilian Research in Intensive Care Network, BRICNet, São Paulo, Brazil.

The success of any donation process requires that potential brain-dead donors (PBDD) are detected and referred early to professionals responsible for their evaluation and conversion to actual donors. The intensivist plays a crucial role in organ donation. However, identification and referral of PBDDs may be suboptimal in the critical care environment. Read More

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http://dx.doi.org/10.1007/s00134-019-05574-5DOI Listing

10 tips for intensive care management of transplanted liver patients.

Intensive Care Med 2019 Mar 28;45(3):377-379. Epub 2019 Feb 28.

Intensive Care Unit and Anaesthesiology Department, PhyMedExp, University of Montpellier Saint-Eloi Hospital, INSERM U1046, CNRS, UMR 9214, 80 avenue Augustin Fliche, 34295, Montpellier Cedex 5, France.

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http://link.springer.com/10.1007/s00134-019-05579-0
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http://dx.doi.org/10.1007/s00134-019-05579-0DOI Listing
March 2019
5 Reads

Feasibility and safety of extracorporeal CO removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study.

Intensive Care Med 2019 Feb 21. Epub 2019 Feb 21.

Alma Mater Studiorum - Università di Bologna, Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Policlinico di Sant'Orsola, Via Massarenti, 9, 40138, Bologna, Italy.

Purpose: We assessed feasibility and safety of extracorporeal carbon dioxide removal (ECCOR) to facilitate ultra-protective ventilation (V 4 mL/kg and P ≤ 25 cmHO) in patients with moderate acute respiratory distress syndrome (ARDS).

Methods: Prospective multicenter international phase 2 study. Primary endpoint was the proportion of patients achieving ultra-protective ventilation with PaCO not increasing more than 20% from baseline, and arterial pH > 7. Read More

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http://dx.doi.org/10.1007/s00134-019-05567-4DOI Listing
February 2019

What respiratory targets should be recommended in patients with brain injury and respiratory failure?

Intensive Care Med 2019 Feb 18. Epub 2019 Feb 18.

Service de Médecine Intensive-Réanimation, Hospices Civils de Lyon, Lyon, France.

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http://dx.doi.org/10.1007/s00134-019-05556-7DOI Listing
February 2019
1 Read

Prolonged corrected QT interval is associated with short-term and long-term mortality in critically ill patients: results from the FROG-ICU study.

Intensive Care Med 2019 Feb 11. Epub 2019 Feb 11.

Department of Anesthesiology, Critical Care and Burn Unit, Hôpitaux Universitaires Saint Louis, Lariboisière, Assistance Publique, Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France.

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http://dx.doi.org/10.1007/s00134-019-05555-8DOI Listing
February 2019
1 Read

Challenges in the management of septic shock: a narrative review.

Intensive Care Med 2019 Apr 11;45(4):420-433. Epub 2019 Feb 11.

Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.

While guidelines provide important information on how to approach a patient in septic shock, "many challenges remain" for the management of these patients. In this narrative review, the panel discusses the challenges in identifying the right hemodynamic target, optimization of fluid therapy, selection of vasopressor agents, identification of patients who may benefit from inotropic agents or on the contrary beta-blockade, and use of steroids. The place for microcirculation-targeted therapy is debated as well as the use of alternative techniques (blood purification) and therapies (vitamin C). Read More

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http://dx.doi.org/10.1007/s00134-019-05544-xDOI Listing
April 2019
4 Reads
7.214 Impact Factor

Management of the brain-dead donor in the ICU: general and specific therapy to improve transplantable organ quality.

Intensive Care Med 2019 Mar 11;45(3):343-353. Epub 2019 Feb 11.

Neuro-Intensive Care, Department of Emergency and Intensive Care, San Gerardo Hospital, ASST, Monza, Italy.

Purpose: To provide a practical overview of the management of the potential organ donor in the intensive care unit.

Methods: Seven areas of donor management were considered for this review: hemodynamic management; fluids and electrolytes; respiratory management; endocrine management; temperature management; anaemia and coagulation; infection management. For each subchapter, a narrative review was conducted. Read More

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http://dx.doi.org/10.1007/s00134-019-05551-yDOI Listing
March 2019
2 Reads

Acute kidney injury in trauma patients admitted to the ICU: a systematic review and meta-analysis.

Intensive Care Med 2019 Apr 6;45(4):407-419. Epub 2019 Feb 6.

Department of Anaesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital Ullevål, Oslo, Norway.

Purpose: To perform a systematic review and meta-analysis of acute kidney injury (AKI) in trauma patients admitted to the intensive care unit (ICU).

Methods: We conducted a systematic literature search of studies on AKI according to RIFLE, AKIN, or KDIGO criteria in trauma patients admitted to the ICU (PROSPERO CRD42017060420). We searched PubMed, Cochrane Database of Systematic Reviews, UpToDate, and NICE through 3 December 2018. Read More

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http://dx.doi.org/10.1007/s00134-019-05535-yDOI Listing
April 2019
3 Reads

10 tips for intensive care management of transplanted heart patients.

Intensive Care Med 2019 Mar 6;45(3):374-376. Epub 2019 Feb 6.

Department of Cardiothoracic Anaesthesia and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1007/s00134-019-05545-wDOI Listing

Observational vs randomized: David vs Goliath for thromboprophylaxis in critically ill patients?

Intensive Care Med 2019 Feb 28;45(2):272-274. Epub 2019 Jan 28.

PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295, Montpellier Cedex 5, France.

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http://dx.doi.org/10.1007/s00134-019-05541-0DOI Listing
February 2019
1 Read

Influence of the initial level of consciousness on early, goal-directed mobilization: a post hoc analysis.

Intensive Care Med 2019 Feb 21;45(2):201-210. Epub 2019 Jan 21.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.

Purpose: Early mobilization within 72 h of intensive care unit (ICU) admission improves functional status at hospital discharge. We aimed to assess the effectiveness of early, goal-directed mobilization in critically ill patients across a broad spectrum of initial consciousness levels.

Methods: Post hoc analysis of the international, randomized, controlled, outcome-assessor blinded SOMS trial conducted 2011-2015. Read More

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http://dx.doi.org/10.1007/s00134-019-05528-xDOI Listing
February 2019
5 Reads

Emergency craniotomy in semi-lateral position for posterior fossa hemorrhage evacuation under venoarterial extracorporeal membrane oxygenation.

Intensive Care Med 2019 Jan 21. Epub 2019 Jan 21.

Medical and Infectious Diseases ICU, Bichat-Claude-Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

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http://dx.doi.org/10.1007/s00134-019-05525-0DOI Listing
January 2019

Correction to: Physiological interventions in cardiac arrest: passing the pilot phase.

Intensive Care Med 2019 Feb;45(2):301-303

Departments of Cardiology and Clinical Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

The reference list of the originally published article was incorrect, and now the article has been appropriately modified and updated to reflect the correction information. We apologize for the inconvenience. Read More

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http://dx.doi.org/10.1007/s00134-019-05530-3DOI Listing
February 2019
1 Read

Boosting the injured brain with supplemental energy fuels.

Intensive Care Med 2019 Jan 14. Epub 2019 Jan 14.

NIHR Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/s00134-018-05517-6DOI Listing
January 2019
1 Read

Determination of brain death under extracorporeal life support.

Intensive Care Med 2019 Mar 9;45(3):364-366. Epub 2019 Jan 9.

School of Medicine and Surgery, Milano Bicocca University, Milan, Italy.

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http://link.springer.com/10.1007/s00134-018-05510-z
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http://dx.doi.org/10.1007/s00134-018-05510-zDOI Listing
March 2019
11 Reads

The effect of local anesthetic continuous wound infusion for the prevention of postoperative pneumonia after on-pump cardiac surgery with sternotomy: the STERNOCAT randomized clinical trial.

Intensive Care Med 2019 Jan 7;45(1):33-43. Epub 2019 Jan 7.

Department of Anesthesiology and Critical Care Medicine, Pitié-Salpêtrière Hospital, Institut de Cardiologie, Réanimation de Chirurgie Cardiaque, Sorbonne Université, UMR INSERM 1166, IHU ICAN, Assistance Publique-Hôpitaux de Paris (AP-HP), 47-83 Boulevard de l'Hôpital, 75013, Paris, France.

Purpose: Postoperative pain after cardiac surgery, exacerbated by cough and sternal mobilization, limits clearance of bronchopulmonary secretions and may predispose to postoperative pneumonia. In this study, we tested the ability of local anesthetic continuous wound infusion to prevent pneumonia after cardiac surgery with sternotomy and cardiopulmonary bypass (CPB) owing to better analgesia and bronchopulmonary drainage.

Methods: In this randomized, double-blind, placebo-controlled trial conducted in five academic centers, patients undergoing cardiac surgery with sternotomy and CPB were enrolled from February 2012 until November 2014, and were followed over 30 days. Read More

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http://dx.doi.org/10.1007/s00134-018-5497-xDOI Listing
January 2019
3 Reads

Early extubation followed by immediate noninvasive ventilation vs. standard extubation in hypoxemic patients: a randomized clinical trial.

Intensive Care Med 2019 Jan 10;45(1):62-71. Epub 2018 Dec 10.

Anestesia e Rianimazione, Dipartimento di Scienze Mediche e Chirurgiche, Università "Magna Graecia", Viale Europa (Loc. Germaneto), Catanzaro, Italy.

Purpose: Noninvasive ventilation (NIV) may facilitate withdrawal of invasive mechanical ventilation (i-MV) and shorten intensive care unit (ICU) length of stay (LOS) in hypercapnic patients, while data are lacking on hypoxemic patients. We aim to determine whether NIV after early extubation reduces the duration of i-MV and ICU LOS in patients recovering from hypoxemic acute respiratory failure.

Methods: Highly selected non-hypercapnic hypoxemic patients were randomly assigned to receive NIV after early or standard extubation. Read More

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http://dx.doi.org/10.1007/s00134-018-5478-0DOI Listing
January 2019
12 Reads
7.214 Impact Factor

Physiological interventions in cardiac arrest: passing the pilot phase.

Intensive Care Med 2019 Feb 10;45(2):287-289. Epub 2018 Dec 10.

Departments of Cardiology and Clinical Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00134-018-5492-2DOI Listing
February 2019
1 Read

Prediction of optimal outcomes in organ transplantation.

Intensive Care Med 2019 Mar 27;45(3):367-370. Epub 2018 Nov 27.

Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s00134-018-5472-6DOI Listing
March 2019
1 Read

Quantitative versus standard pupillary light reflex for early prognostication in comatose cardiac arrest patients: an international prospective multicenter double-blinded study.

Intensive Care Med 2018 Dec 26;44(12):2102-2111. Epub 2018 Nov 26.

Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.

Purpose: To assess the ability of quantitative pupillometry [using the Neurological Pupil index (NPi)] to predict an unfavorable neurological outcome after cardiac arrest (CA).

Methods: We performed a prospective international multicenter study (10 centers) in adult comatose CA patients. Quantitative NPi and standard manual pupillary light reflex (sPLR)-blinded to clinicians and outcome assessors-were recorded in parallel from day 1 to 3 after CA. Read More

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http://link.springer.com/10.1007/s00134-018-5448-6
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http://dx.doi.org/10.1007/s00134-018-5448-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280828PMC
December 2018
32 Reads

Focus on ventilation management.

Intensive Care Med 2018 Dec 22;44(12):2254-2256. Epub 2018 Nov 22.

PhyMedExp, University of Montpellier, INSERM U1046, CNRS, UMR 9214, Montpellier, France.

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http://dx.doi.org/10.1007/s00134-018-5476-2DOI Listing
December 2018
2 Reads

Fluid administration for acute circulatory dysfunction using basic monitoring: narrative review and expert panel recommendations from an ESICM task force.

Intensive Care Med 2019 Jan 19;45(1):21-32. Epub 2018 Nov 19.

Department of Intensive Care, CHIREC Hospitals, Université Libre de Bruxelles, 35 Rue Wayez, 1420, Braine L'Alleud, Belgium.

An international team of experts in the field of fluid resuscitation was invited by the ESICM to form a task force to systematically review the evidence concerning fluid administration using basic monitoring. The work included a particular emphasis on pre-ICU hospital settings and resource-limited settings. The work focused on four main questions: (1) What is the role of clinical assessment to guide fluid resuscitation in shock? (2) What basic monitoring is required to perform and interpret a fluid challenge? (3) What defines a fluid challenge in terms of fluid type, ranges of volume, and rate of administration? (4) What are the safety endpoints during a fluid challenge? The expert panel found insufficient evidence to provide recommendations according to the GRADE system, and was only able to make recommendations for basic interventions, based on the available evidence and expert opinion. Read More

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http://dx.doi.org/10.1007/s00134-018-5415-2DOI Listing
January 2019
40 Reads

Professional burnout among physicians and nurses in Asian intensive care units: a multinational survey.

Intensive Care Med 2018 Dec 16;44(12):2079-2090. Epub 2018 Nov 16.

Division of Respiratory and Critical Care Medicine, University Medicine Cluster, National University Hospital, National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 10, Singapore, 119228, Singapore.

Purpose: Professional burnout is a multidimensional syndrome comprising emotional exhaustion, depersonalization, and diminished sense of personal accomplishment, and is associated with poor staff health and decreased quality of medical care. We investigated burnout prevalence and its associated risk factors among Asian intensive care unit (ICU) physicians and nurses.

Methods: We conducted a cross-sectional survey of 159 ICUs in 16 Asian countries and regions. Read More

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http://link.springer.com/10.1007/s00134-018-5432-1
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http://dx.doi.org/10.1007/s00134-018-5432-1DOI Listing
December 2018
12 Reads
7.214 Impact Factor

Focus on randomised clinical trials.

Intensive Care Med 2018 Dec 15;44(12):2257-2259. Epub 2018 Nov 15.

Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://link.springer.com/10.1007/s00134-018-5468-2
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http://dx.doi.org/10.1007/s00134-018-5468-2DOI Listing
December 2018
12 Reads

Targeting two different levels of both arterial carbon dioxide and arterial oxygen after cardiac arrest and resuscitation: a randomised pilot trial.

Intensive Care Med 2018 Dec 14;44(12):2112-2121. Epub 2018 Nov 14.

Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Purpose: We assessed the effects of targeting low-normal or high-normal arterial carbon dioxide tension (PaCO) and normoxia or moderate hyperoxia after out-of-hospital cardiac arrest (OHCA) on markers of cerebral and cardiac injury.

Methods: Using a 2 factorial design, we randomly assigned 123 patients resuscitated from OHCA to low-normal (4.5-4. Read More

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http://link.springer.com/10.1007/s00134-018-5453-9
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http://dx.doi.org/10.1007/s00134-018-5453-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280824PMC
December 2018
20 Reads

Unrecognised myocardial infarction and its relationship to outcome in critically ill patients with cardiovascular disease.

Intensive Care Med 2018 Dec 29;44(12):2059-2069. Epub 2018 Oct 29.

Department of Anaesthesia, Critical Care and Pain Medicine, University of Edinburgh, 2nd Floor Anaesthetics Corridor, Royal Infirmary Edinburgh, Old Dalkeith Road, Edinburgh, EH16 4SA, UK.

Purpose: To establish the incidence of myocardial infarction (MI) in ICU patients with co-existing cardiovascular disease (CVD), and explore its association with long-term survival.

Methods: In a multi-centre prospective cohort study in 11 UK ICUs, we enrolled 273 critically ill patients with co-existing CVD. We measured troponin I (cTnI) with a high sensitivity assay for 10 days; ECGs were carried out daily for 5 days and analysed by blinded cardiologists for dynamic changes. Read More

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http://link.springer.com/10.1007/s00134-018-5425-0
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http://dx.doi.org/10.1007/s00134-018-5425-0DOI Listing
December 2018
8 Reads

Diaphragm myoclonus-induced autotriggering during neurally adjusted ventilatory assist.

Intensive Care Med 2018 Dec 26;44(12):2309-2311. Epub 2018 Oct 26.

Istituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore, L.go F. Vito, Rome, 00168, Italy.

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http://dx.doi.org/10.1007/s00134-018-5430-3DOI Listing
December 2018
1 Read

Focus on paediatrics 2018.

Intensive Care Med 2018 Dec 23;44(12):2267-2270. Epub 2018 Oct 23.

Respiratory, Critical Care and Anaesthesia Unit, University College London Great Ormond Street, Institute of Child Health, London, UK.

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http://dx.doi.org/10.1007/s00134-018-5421-4DOI Listing
December 2018
1 Read

Is there still a place for noninvasive ventilation in acute hypoxemic respiratory failure?

Intensive Care Med 2018 Dec 23;44(12):2248-2250. Epub 2018 Oct 23.

Centro di Ricerca Coordinata di Insufficienza Respiratoria, Università degli Studi di Milano, Milan, Italy.

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http://link.springer.com/10.1007/s00134-018-5416-1
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http://dx.doi.org/10.1007/s00134-018-5416-1DOI Listing
December 2018
6 Reads

Monitoring of neuromuscular blockade: a comparison of train-of-four and the Campbell diagram.

Intensive Care Med 2018 Dec 22;44(12):2305-2306. Epub 2018 Oct 22.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.

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http://link.springer.com/10.1007/s00134-018-5420-5
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http://dx.doi.org/10.1007/s00134-018-5420-5DOI Listing
December 2018
20 Reads

Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.

Intensive Care Med 2018 Nov 21;44(11):1849-1858. Epub 2018 Oct 21.

Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania Perelman School of Medicine, 3600 Spruce Street 5039 Gates Building, Philadelphia, PA, 19104, USA.

Purpose: A causal biomarker for acute respiratory distress syndrome (ARDS) could fuel precision therapy options. Plasma angiopoietin-2 (ANG2), a vascular permeability marker, is a strong candidate on the basis of experimental and observational evidence. We used genetic causal inference methods-Mendelian randomization and mediation-to infer potential effects of plasma ANG2. Read More

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http://link.springer.com/10.1007/s00134-018-5328-0
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http://dx.doi.org/10.1007/s00134-018-5328-0DOI Listing
November 2018
16 Reads

Small volume resuscitation with 20% albumin in intensive care: physiological effects : The SWIPE randomised clinical trial.

Intensive Care Med 2018 Nov 21;44(11):1797-1806. Epub 2018 Oct 21.

Department of Intensive Care, Austin Hospital, Melbourne, Australia.

Purpose: We set out to assess the resuscitation fluid requirements and physiological and clinical responses of intensive care unit (ICU) patients resuscitated with 20% albumin versus 4-5% albumin.

Methods: We performed a randomised controlled trial in 321 adult patients requiring fluid resuscitation within 48 h of admission to three ICUs in Australia and the UK.

Results: The cumulative volume of resuscitation fluid at 48 h (primary outcome) was lower in the 20% albumin group than in the 4-5% albumin group [median difference - 600 ml, 95% confidence interval (CI) - 800 to - 400; P < 0. Read More

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http://link.springer.com/10.1007/s00134-018-5253-2
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http://dx.doi.org/10.1007/s00134-018-5253-2DOI Listing
November 2018
46 Reads

Is your smartphone the future of physiologic monitoring?

Intensive Care Med 2018 Oct 19. Epub 2018 Oct 19.

Anesthesiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00134-018-5419-yDOI Listing
October 2018
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An intensive midsummer night's dream.

Intensive Care Med 2019 Apr 17;45(4):552-556. Epub 2018 Oct 17.

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.). Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.1007/s00134-018-5408-1DOI Listing
April 2019
4 Reads

Understanding hypoxemia on ECCOR: back to the alveolar gas equation.

Intensive Care Med 2019 Feb 15;45(2):255-256. Epub 2018 Oct 15.

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

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http://link.springer.com/10.1007/s00134-018-5409-0
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http://dx.doi.org/10.1007/s00134-018-5409-0DOI Listing
February 2019
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Discussion about "Association of frailty with short-term outcomes, organ support and resource use in critically ill patients".

Intensive Care Med 2018 11 15;44(11):2014-2016. Epub 2018 Oct 15.

Graduate Program in Translational Medicine and Department of Critical Care, D'Or Institute for Research and Education, Rio De Janeiro, Brazil.

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http://link.springer.com/10.1007/s00134-018-5382-7
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http://dx.doi.org/10.1007/s00134-018-5382-7DOI Listing
November 2018
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