913 results match your criteria Anaesthesia and Intensive Care Medicine [Journal]


Transport of critically ill COVID-19 patients.

Intensive Care Med 2020 May 25. Epub 2020 May 25.

Anesthesia, Critical Care and Pain Management, Al Adan Hospital, Ministry of Health, Kuwait City, Kuwait.

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http://dx.doi.org/10.1007/s00134-020-06115-1DOI Listing

Focus on noninvasive respiratory support before and after mechanical ventilation in patients with acute respiratory failure.

Intensive Care Med 2020 May 25. Epub 2020 May 25.

Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Dr. Ernest Borges Road, Parel, Mumbai, India.

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http://dx.doi.org/10.1007/s00134-020-06100-8DOI Listing

The attributable mortality of acute respiratory distress syndrome.

Intensive Care Med 2020 May 25. Epub 2020 May 25.

Department of Anesthesia, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s00134-020-06099-yDOI Listing

Epileptic seizure discharges in patients after open chamber cardiac surgery-a prospective prevalence pilot study using continuous electroencephalography.

Intensive Care Med 2020 May 13. Epub 2020 May 13.

Heart and Brain Research Group, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany.

Purpose: Patients undergoing cardiac surgery often develop delirium which increases the risk of postoperative morbidity and leads to a reduced quality of life. Retrospective studies show a higher incidence of delirium in patients with seizures. However, these studies do not systematically detect subclinical seizures, so the incidence of seizures after cardiac surgery remains speculative. Read More

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http://dx.doi.org/10.1007/s00134-020-06073-8DOI Listing

Machine learning in intensive care medicine: ready for take-off?

Intensive Care Med 2020 May 12. Epub 2020 May 12.

Department of Intensive Care Medicine, Research VUmc Intensive Care (REVIVE), Amsterdam Medical Data Science (AMDS), Amsterdam Cardiovascular Sciences (ACS), Amsterdam Infection and Immunity Institute (AI&II), Amsterdam UMC, Location VUmc, VU Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00134-020-06045-yDOI Listing

Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation.

Intensive Care Med 2020 Apr 28. Epub 2020 Apr 28.

Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s00134-020-06059-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186535PMC
April 2020
7.214 Impact Factor

Missed or delayed diagnosis of ARDS: a common and serious problem.

Intensive Care Med 2020 Apr 23. Epub 2020 Apr 23.

Lung Biology Group, Regenerative Medicine Institute (REMEDI) at CÚRAM Centre for Research in Medical Devices, Biomedical Sciences Building, National University of Ireland Galway, Galway, Ireland.

Clinical recognition of acute respiratory distress syndrome (ARDS) is delayed or missed entirely in a substantial proportion of patients. In the LUNG SAFE study, the largest international cohort of patients with ARDS, investigators were able to determine if ARDS was present, and at what stage the clinician made the diagnosis of ARDS. The diagnosis of ARDS was delayed or missed in two-thirds of patients, with the diagnosis missed entirely in 40% of patients, while ARDS recognition ranged from 51% in mild ARDS to 79% in severe cases. Read More

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http://dx.doi.org/10.1007/s00134-020-06035-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176813PMC

Thrombotic events in SARS-CoV-2 patients: an urgent call for ultrasound screening.

Intensive Care Med 2020 Apr 22. Epub 2020 Apr 22.

Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, Unit of Anaesthesia and Intensive Care, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1007/s00134-020-06040-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175449PMC

First-attempt success is associated with fewer complications related to intubation in the intensive care unit.

Intensive Care Med 2020 Apr 22. Epub 2020 Apr 22.

Intensive Care Unit and Transplantation, Department of Anesthesia and Critical Care B (DAR B), Hôpital Saint Eloi, CHU de Montpellier, PhyMedExp, Université de Montpellier, 80, Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France.

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http://dx.doi.org/10.1007/s00134-020-06041-2DOI Listing

COVID-19 pneumonia: different respiratory treatments for different phenotypes?

Intensive Care Med 2020 Apr 14. Epub 2020 Apr 14.

Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, Health Centre for Human and Applied Physiological Sciences, London, UK.

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http://dx.doi.org/10.1007/s00134-020-06033-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154064PMC

Modified 4T score for heparin-induced thrombocytopenia diagnosis in VA-ECMO patients.

Intensive Care Med 2020 Mar 30. Epub 2020 Mar 30.

Department of Anesthesia and Critical Care Medicine, Hôpital Européen Georges Pompidou, Paris, France.

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http://dx.doi.org/10.1007/s00134-020-06011-8DOI Listing

Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19).

Intensive Care Med 2020 05 28;46(5):854-887. Epub 2020 Mar 28.

Adult Critical Care, St George's University Hospitals NHS Foundation Trust & St George's University of London, London, UK.

Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed.

Methods: We formed a panel of 36 experts from 12 countries. Read More

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http://dx.doi.org/10.1007/s00134-020-06022-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101866PMC
May 2020
7.214 Impact Factor

Are the instruments for quality of life assessment comparable between cultures? No.

Intensive Care Med 2020 Mar 27. Epub 2020 Mar 27.

Department of Anesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.

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http://dx.doi.org/10.1007/s00134-020-06007-4DOI Listing
March 2020
7.214 Impact Factor

Functional mobility recovery predicts readmission to the surgical intensive care unit.

Intensive Care Med 2020 May 27;46(5):1054-1056. Epub 2020 Mar 27.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s00134-020-05972-0DOI Listing

Tracheostomy in traumatic brain injured: solving the conundrum of the immortal time bias.

Intensive Care Med 2020 Mar 27. Epub 2020 Mar 27.

School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy.

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http://dx.doi.org/10.1007/s00134-020-06016-3DOI Listing

Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis.

Intensive Care Med 2020 Mar 23. Epub 2020 Mar 23.

Cardiovascular Research Institute, University of California, San Francisco, CA, USA.

Purpose: Previous studies assessing impact of acute respiratory distress syndrome (ARDS) on mortality have shown conflicting results. We sought to assess the independent association of ARDS with in-hospital mortality among intensive care unit (ICU) patients with sepsis.

Methods: We studied two prospective sepsis cohorts drawn from the Early Assessment of Renal and Lung Injury (EARLI; n = 474) and Validating Acute Lung Injury markers for Diagnosis (VALID; n = 337) cohorts. Read More

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http://dx.doi.org/10.1007/s00134-020-06010-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224051PMC

Focus on neuro-critical care: combined interventions to improve relevant outcomes.

Intensive Care Med 2020 May 23;46(5):1027-1029. Epub 2020 Mar 23.

Department of Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00134-020-06014-5DOI Listing

Lung ultrasound and B-lines quantification inaccuracy: B sure to have the right solution.

Intensive Care Med 2020 May 18;46(5):1081-1083. Epub 2020 Mar 18.

Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1007/s00134-020-06005-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087507PMC

Noninvasive respiratory support in the hypoxaemic peri-operative/periprocedural patient: a joint ESA/ESICM guideline.

Intensive Care Med 2020 Apr 10;46(4):697-713. Epub 2020 Mar 10.

Department of Paediatric and Obstetric Anaesthesia, Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Hypoxaemia is a potential life-threatening yet common complication in the peri-operative and periprocedural patient (e.g. during an invasive procedure at risk of deterioration of gas exchange, such as bronchoscopy). Read More

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http://dx.doi.org/10.1007/s00134-020-05948-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223056PMC

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.

Intensive Care Med 2020 04 3;46(4):586-590. Epub 2020 Mar 3.

The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michaels Hospital, 209 Victoria Street, Room 608, Toronto, ON, M5B 1T8, Canada.

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http://dx.doi.org/10.1007/s00134-020-05985-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079879PMC

Guidelines seek unbiased recommendations.

Intensive Care Med 2020 May 2;46(5):1065-1069. Epub 2020 Mar 2.

Department of Anaesthesia and Intensive Care Medicine, Humanitas Clinical and Research Centre-IRCCS, Rozzano, Milan, Italy.

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http://dx.doi.org/10.1007/s00134-020-05968-wDOI Listing

Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe: a CENTER-TBI analysis.

Intensive Care Med 2020 May 25;46(5):995-1004. Epub 2020 Feb 25.

Neuroscience Intensive Care Unit, Department of Anesthesia and Critical Care, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.

Purpose: To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (ICU) patients with traumatic brain injury (TBI) in Europe, and to quantify variation across centers.

Methods: This is a prospective observational multicenter study conducted across 18 countries in Europe and Israel. Admission characteristics, clinical data, and outcome were described at patient- and center levels. Read More

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http://dx.doi.org/10.1007/s00134-020-05965-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210239PMC

Lung-kidney cross-talk in the critically ill: insights from the Lung Safe study.

Intensive Care Med 2020 May 24;46(5):1072-1073. Epub 2020 Feb 24.

Regenerative Medicine Institute (REMEDI) at CÚRAM Centre for Research in Medical Devices, Biomedical Sciences Building, National University of Ireland Galway, Galway, Ireland.

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http://dx.doi.org/10.1007/s00134-020-05962-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223483PMC

ICU-acquired weakness.

Intensive Care Med 2020 Apr 19;46(4):637-653. Epub 2020 Feb 19.

Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Critically ill patients often acquire neuropathy and/or myopathy labeled ICU-acquired weakness. The current insights into incidence, pathophysiology, diagnostic tools, risk factors, short- and long-term consequences and management of ICU-acquired weakness are narratively reviewed. PubMed was searched for combinations of "neuropathy", "myopathy", "neuromyopathy", or "weakness" with "critical illness", "critically ill", "ICU", "PICU", "sepsis" or "burn". Read More

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http://dx.doi.org/10.1007/s00134-020-05944-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224132PMC

Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop.

Intensive Care Med 2020 May 18;46(5):930-942. Epub 2020 Feb 18.

Department of Anesthesia, Burn and Critical Care, University Hospitals Saint-Louis - Lariboisière, AP-HP, Paris, France.

Background: Conducting research in critically-ill patient populations is challenging, and most randomized trials of critically-ill patients have not achieved pre-specified statistical thresholds to conclude that the intervention being investigated was beneficial.

Methods: In 2019, a diverse group of patient representatives, regulators from the USA and European Union, federal grant managers, industry representatives, clinical trialists, epidemiologists, and clinicians convened the First Critical Care Clinical Trialists (3CT) Workshop to discuss challenges and opportunities in conducting and assessing critical care trials. Herein, we present the advantages and disadvantages of available methodologies for clinical trial design, conduct, and analysis, and a series of recommendations to potentially improve future trials in critical care. Read More

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http://dx.doi.org/10.1007/s00134-020-05934-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224097PMC

Updated nomenclature of delirium and acute encephalopathy: statement of ten Societies.

Intensive Care Med 2020 May 13;46(5):1020-1022. Epub 2020 Feb 13.

Departments of Anesthesiology, Critical Care Medicine, Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s00134-019-05907-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210231PMC

Extracorporeal membrane oxygenation for refractory cardiac arrest: a retrospective multicenter study.

Intensive Care Med 2020 May 12;46(5):973-982. Epub 2020 Feb 12.

Department of Cardiothoracic Anesthesia and Intensive Care, Advanced Heart Failure and Mechanical Circulatory Support Program, San Raffaele Hospital, Vita-Salute University, Milan, Italy.

Purpose: The aim of this study was to assess the neurologic outcome following extracorporeal cardiopulmonary resuscitation (ECPR) in five European centers.

Methods: Retrospective database analysis of prospective observational cohorts of patients undergoing ECPR (January 2012-December 2016) was performed. The primary outcome was 3-month favorable neurologic outcome (FO), defined as the cerebral performance categories of 1-2. Read More

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http://dx.doi.org/10.1007/s00134-020-05926-6DOI Listing

Correction to: Use of combined cardiac and lung ultrasound to predict weaning failure in elderly, high-risk cardiac patients: a pilot study.

Intensive Care Med 2020 Apr;46(4):831

Department of Anaesthesia and Intensive Care, Istituto Di Ricovero E Cura a Carattere Scientifico, Policlinico San Matteo Foundation, Pavia, Italy.

The original version of this article unfortunately contained a mistake. Two of the authors forgot to mention recent collaborations in their COI. The correct COI would have been: Dr Silvia Mongodi received feed for lectures from General Electrics; and Professor Francesco Mojoli received feed for lectures from General Electrics, Hamilton Medical and SEDA SpA. Read More

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http://dx.doi.org/10.1007/s00134-020-05956-0DOI Listing

Tracheostomy practice and timing in traumatic brain-injured patients: a CENTER-TBI study.

Intensive Care Med 2020 May 5;46(5):983-994. Epub 2020 Feb 5.

School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy.

Purpose: Indications and optimal timing for tracheostomy in traumatic brain-injured (TBI) patients are uncertain. This study aims to describe the patients' characteristics, timing, and factors related to the decision to perform a tracheostomy and differences in strategies among different countries and assess the effect of the timing of tracheostomy on patients' outcomes.

Methods: We selected TBI patients from CENTER-TBI, a prospective observational longitudinal cohort study, with an intensive care unit stay ≥ 72 h. Read More

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http://dx.doi.org/10.1007/s00134-020-05935-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223805PMC

Antimicrobial-associated harm in critical care: a narrative review.

Intensive Care Med 2020 02 29;46(2):225-235. Epub 2020 Jan 29.

John V Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.

The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials outweighs any potential harm is a significant barrier to improved stewardship of these vital agents. Antimicrobial stewardship may be perceived as utilitarian rationing, seeking to preserve the availability of effective antimicrobials by limiting the development of resistance in a manner which could conflict with the immediate treatment of the patient in need. This view does not account for the growing evidence of antimicrobial-associated harm to individual patients. Read More

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http://dx.doi.org/10.1007/s00134-020-05929-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046486PMC
February 2020

Perioperative maintenance fluid therapy in patients undergoing thoracic surgery: more risks than benefits?

Intensive Care Med 2020 Mar 29;46(3):552-553. Epub 2020 Jan 29.

Department of Anesthesiology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1007/s00134-020-05936-4DOI Listing

The wicked path of causal inference in observational studies.

Intensive Care Med 2020 Apr 24;46(4):799-801. Epub 2020 Jan 24.

Department of Intensive Care Unit 4131, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00134-020-05938-2DOI Listing

A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC).

Intensive Care Med 2020 May 21;46(5):919-929. Epub 2020 Jan 21.

Section of Neurosurgery, University of Manitoba, GB1, 820 Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada.

Background: Current guidelines for the treatment of adult severe traumatic brain injury (sTBI) consist of high-quality evidence reports, but they are no longer accompanied by management protocols, as these require expert opinion to bridge the gap between published evidence and patient care. We aimed to establish a modern sTBI protocol for adult patients with both intracranial pressure (ICP) and brain oxygen monitors in place.

Methods: Our consensus working group consisted of 42 experienced and actively practicing sTBI opinion leaders from six continents. Read More

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http://dx.doi.org/10.1007/s00134-019-05900-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210240PMC

Machine learning for the prediction of sepsis: a systematic review and meta-analysis of diagnostic test accuracy.

Intensive Care Med 2020 Mar 21;46(3):383-400. Epub 2020 Jan 21.

Department of Intensive Care Medicine, Research VUmc Intensive Care (REVIVE), Amsterdam Medical Data Science (AMDS), Amsterdam Cardiovascular Sciences (ACS), Amsterdam Infection and Immunity Institute (AI&II), Amsterdam UMC, location VUmc, VU Amsterdam, Amsterdam, The Netherlands.

Purpose: Early clinical recognition of sepsis can be challenging. With the advancement of machine learning, promising real-time models to predict sepsis have emerged. We assessed their performance by carrying out a systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1007/s00134-019-05872-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067741PMC

What is new in non-ventilated ICU-acquired pneumonia?

Intensive Care Med 2020 Mar 14;46(3):488-491. Epub 2020 Jan 14.

University of Paris, IAME, INSERM, 75018, Paris, France.

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http://dx.doi.org/10.1007/s00134-019-05859-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223396PMC

Use of combined cardiac and lung ultrasound to predict weaning failure in elderly, high-risk cardiac patients: a pilot study.

Intensive Care Med 2020 Mar 8;46(3):475-484. Epub 2020 Jan 8.

Department of Anaesthesia and Intensive Care, Istituto Di Ricovero E Cura a Carattere Scientifico, Policlinico San Matteo Foundation, Pavia, Italy.

Purpose: Weaning failure from mechanical ventilation may be due to lung de-recruitment or weaning-induced pulmonary oedema (WIPO). Both can be diagnosed by lung ultrasound (LUS) and transthoracic echocardiography (TTE), respectively. We conducted a prospective observational study, combining TTE and LUS, to determine if LUS alone may identify elderly patients at high risk of weaning or extubation failure. Read More

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http://dx.doi.org/10.1007/s00134-019-05902-9DOI Listing

Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine.

Intensive Care Med 2020 Apr 7;46(4):673-696. Epub 2020 Jan 7.

Department of Anaesthesia and Intensive Care Medicine, Humanitas Clinical and Research Centre-IRCCS, Rozzano, Milan, Italy.

Objective: To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults.

Design: A task force involving 13 international experts and three methodologists used the GRADE approach for guideline development.

Methods: The task force identified four main topics: red blood cell transfusion thresholds, red blood cell transfusion avoidance strategies, platelet transfusion, and plasma transfusion. Read More

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http://dx.doi.org/10.1007/s00134-019-05884-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223433PMC

The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study.

Intensive Care Med 2020 01 29;46(1):57-69. Epub 2019 Nov 29.

Dep. of Clinical Medicine, University of Bergen, Bergen, Norway.

Purpose: Premorbid conditions affect prognosis of acutely-ill aged patients. Several lines of evidence suggest geriatric syndromes need to be assessed but little is known on their relative effect on the 30-day survival after ICU admission. The primary aim of this study was to describe the prevalence of frailty, cognition decline and activity of daily life in addition to the presence of comorbidity and polypharmacy and to assess their influence on 30-day survival. Read More

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http://dx.doi.org/10.1007/s00134-019-05853-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223711PMC
January 2020
4 Reads

Trials on oxygen supplementation in sepsis: better late than never.

Intensive Care Med 2020 01 26;46(1):116-118. Epub 2019 Nov 26.

Department of Critical Care Medicine, Guy's and St Thomas' NHS Foundation Trust, London, SE17EH, UK.

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http://dx.doi.org/10.1007/s00134-019-05874-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223490PMC
January 2020

ECLS-associated infections in adults: what we know and what we don't yet know.

Intensive Care Med 2020 02 25;46(2):182-191. Epub 2019 Nov 25.

Columbia University College of Physicians and Surgeons, New York-Presbyterian Hospital, New York, NY, USA.

Extracorporeal life support (ECLS) is increasingly used in the management of patients with severe cardiopulmonary disease. Infections are frequently the etiologies underlying the respiratory, and occasionally cardiac, failure that necessitates ECLS. Just as importantly, infections are among the most commonly reported adverse events during ECLS. Read More

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http://dx.doi.org/10.1007/s00134-019-05847-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222121PMC
February 2020

The artificial kidney induces AKI? Not if we apply "kidney-protective" renal replacement therapy.

Intensive Care Med 2020 Mar 20;46(3):510-512. Epub 2019 Nov 20.

Royal Surrey NHS Foundation Trust, Egerton Road, Guildford, GU2 7XX, UK.

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http://dx.doi.org/10.1007/s00134-019-05864-yDOI Listing

The Janus faces of bicarbonate therapy in the ICU.

Intensive Care Med 2020 Mar 11;46(3):516-518. Epub 2019 Nov 11.

PhyMedExp, INSERM U1046, CNRS, UMR 9214, Centre Hospitalier Universitaire Montpellier, University of Montpellier, 34295, Montpellier Cedex 5, France.

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http://dx.doi.org/10.1007/s00134-019-05835-3DOI Listing

Effect of lung recruitment maneuver on oxygenation, physiological parameters and mortality in acute respiratory distress syndrome patients: a systematic review and meta-analysis.

Intensive Care Med 2019 12 7;45(12):1691-1702. Epub 2019 Nov 7.

Anesthesiology and Intensive Care; Anesthesia and Critical Care Department B, Saint Eloi Teaching Hospital, PhyMedExp, Centre Hospitalier Universitaire Montpellier, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295, Montpellier cedex 5, France.

Purpose: Among acute respiratory distress syndrome (ARDS) patients in intensive care units, the efficacy of lung recruitment maneuver (LRM) use is uncertain taking into account the most recent randomized controlled trials (RCTs). We aimed to estimate the effect of LRMs on mortality from ARDS.

Methods: In this systematic review and meta-analysis, we searched for RCTs comparing mechanical ventilation with and without LRMs in adults with ARDS. Read More

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http://dx.doi.org/10.1007/s00134-019-05821-9DOI Listing
December 2019

Ethical climate and intention to leave among critical care clinicians: an observational study in 68 intensive care units across Europe and the United States.

Intensive Care Med 2020 01 5;46(1):46-56. Epub 2019 Nov 5.

Department of Intensive Care Medicine, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium.

Purpose: Apart from organizational issues, quality of inter-professional collaboration during ethical decision-making may affect the intention to leave one's job. To determine whether ethical climate is associated with the intention to leave after adjustment for country, ICU and clinicians characteristics.

Methods: Perceptions of the ethical climate among clinicians working in 68 adult ICUs in 12 European countries and the US were measured using a self-assessment questionnaire, together with job characteristics and intent to leave as a sub-analysis of the Dispropricus study. Read More

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http://dx.doi.org/10.1007/s00134-019-05829-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954133PMC
January 2020

Characterization and validation of a novel measure of septic shock severity.

Intensive Care Med 2020 01 4;46(1):135-137. Epub 2019 Nov 4.

Department of Medicine, The Pulmonary Center, Boston University School of Medicine, 72 East Concord St., R-304, Boston, MA, 02118, USA.

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http://dx.doi.org/10.1007/s00134-019-05837-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954971PMC
January 2020

Correction to: Focus on ventilation and ARDS: recent insights.

Intensive Care Med 2020 01;46(1):152

Interdepartmental Division of Critical Care Medicine, Departments of Medicine and Physiology and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

The original version of this article unfortunately contained a mistake. Read More

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http://dx.doi.org/10.1007/s00134-019-05843-3DOI Listing
January 2020

Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project.

Intensive Care Med 2019 12 29;45(12):1703-1717. Epub 2019 Oct 29.

General Internal Medicine, Infectious Diseases, and Psychometric Medicine, Ghent University Hospital, Ghent, Belgium.

Purpose: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).

Methods: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis. Read More

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http://dx.doi.org/10.1007/s00134-019-05819-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863788PMC
December 2019
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A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC).

Intensive Care Med 2019 12 28;45(12):1783-1794. Epub 2019 Oct 28.

Department of Neurological Surgery, University of Washington, Mailstop 359766, 325 Ninth Ave, Seattle, WA, 98104-2499, USA.

Background: Management algorithms for adult severe traumatic brain injury (sTBI) were omitted in later editions of the Brain Trauma Foundation's sTBI Management Guidelines, as they were not evidence-based.

Methods: We used a Delphi-method-based consensus approach to address management of sTBI patients undergoing intracranial pressure (ICP) monitoring. Forty-two experienced, clinically active sTBI specialists from six continents comprised the panel. Read More

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http://dx.doi.org/10.1007/s00134-019-05805-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863785PMC
December 2019

What's new in ultrasound-based assessment of organ perfusion in the critically ill: expanding the bedside clinical monitoring window for hypoperfusion in shock.

Intensive Care Med 2020 Apr 25;46(4):775-779. Epub 2019 Oct 25.

Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1007/s00134-019-05791-yDOI Listing

Less is more, but are we doing enough?

Intensive Care Med 2020 01 24;46(1):113-115. Epub 2019 Oct 24.

Department of Critical Care Medicine, Hospital Medica Sur, Mexico City, Mexico.

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http://dx.doi.org/10.1007/s00134-019-05831-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954141PMC
January 2020