23,552 results match your criteria Anaesthesia Critical Care & Pain Medicine[Journal]


Post-traumatic stress disorder and postpartum depression and their reported association with recent labor and delivery: a questionnaire survey cohort.

Int J Obstet Anesth 2020 May 11;43:18-24. Epub 2020 May 11.

Division of Anesthesia, Critical Care and Pain, Tel Aviv Sourasky Medical Center, Israel. Electronic address:

Background: We aimed to investigate the index traumatic event associated with post-traumatic stress disorder (PTSD) and evaluate the timing of the onset of symptoms in relation to the recent delivery.

Methods: Questionnaire study regarding prior exposure to traumatic events, PTSD, postpartum depression (PPD) and fear of childbirth among women two to 12 months postpartum, recruited via targeted internet sites.

Results: Questionnaires were completed by 143 women, with PPD reported by 22 (15. Read More

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http://dx.doi.org/10.1016/j.ijoa.2020.04.009DOI Listing

Human intestinal microbiota derived metabolism signature from a North American native botanical Oplopanax horridus with UPLC/Q-TOF-MS analysis.

Biomed Chromatogr 2020 Jun 4:e4911. Epub 2020 Jun 4.

Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL, USA.

Oplopanax horridus, distributed in North America, is an herbal medicine traditionally used by Pacific indigenous peoples for various medical conditions. After oral ingestion, constituents in O. horridus extract (OhE) could be converted to their metabolites by enteric microbiome before absorption. Read More

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http://dx.doi.org/10.1002/bmc.4911DOI Listing

Antepartum Aspirin Administration Reduces Activin A and Cardiac Global Longitudinal Strain in Preeclamptic Women.

J Am Heart Assoc 2020 Jun 4:e015997. Epub 2020 Jun 4.

Department of Anesthesia and Critical Care University of Chicago IL.

Background Approximately 60% of women have Stage B heart failure 1 year after a preeclamptic delivery. Emerging evidence suggests that the profibrotic growth factor activin A, which has been shown to induce cardiac fibrosis and hypertrophy, is elevated in preeclampsia and may be inhibited by aspirin therapy. We hypothesized that preeclamptic women receiving aspirin would have lower activin A levels and reduced global longitudinal strain (GLS), a sensitive measure of cardiac dysfunction, than women who do not receive aspirin. Read More

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http://dx.doi.org/10.1161/JAHA.119.015997DOI Listing

COVID-19 and kidney transplantation: an Italian Survey and Consensus.

J Nephrol 2020 Jun 3. Epub 2020 Jun 3.

Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.

Italy was the first Western country to face the COVID-19 pandemic. Here we report the results of a national survey on kidney transplantation activity in February and March 2020, and the results of a three-round Delphi consensus promoted by four scientific societies: the Italian Society of Organ Transplantation, the Italian Society of Nephrology, the Italian Society of Anesthesia and Intensive Care, and the Italian Group on Antimicrobial Stewardship. All 41 Italian transplant centers were invited to express their opinion in the Delphi rounds along with a group of seven experts. Read More

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http://dx.doi.org/10.1007/s40620-020-00755-8DOI Listing

Central venous catheter bundle adherence: Kamishibai card (K-card) rounding for central-line-associated bloodstream infection (CLABSI) prevention.

Infect Control Hosp Epidemiol 2020 Jun 4:1-6. Epub 2020 Jun 4.

Infection Prevention and Control, Boston Children's Hospital, Boston, Massachusetts.

Objective: To institute facility-wide Kamishibai card (K-card) rounding for central venous catheter (CVC) maintenance bundle education and adherence and to evaluate its impact on bundle reliability and central-line-associated bloodstream infection (CLABSI) rates.

Design: Quality improvement project.

Setting: Inpatient units at a large, academic freestanding children's hospital. Read More

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http://dx.doi.org/10.1017/ice.2020.235DOI Listing

Comparison of intrathecal morphine with continuous patient-controlled epidural anesthesia versus intrathecal morphine alone for post-cesarean section analgesia: a randomized controlled trial.

BMC Anesthesiol 2020 Jun 3;20(1):138. Epub 2020 Jun 3.

Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.

Background: Several neuraxial techniques have demonstrated effective post-cesarean section analgesia. According to previous reports, it is likely that patient-controlled epidural analgesia (PCEA) without opioids is inferior to intrathecal morphine (IM) alone for post-cesarean section analgesia. However, little is known whether adding PCEA to IM is effective or not. Read More

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http://dx.doi.org/10.1186/s12871-020-01050-6DOI Listing

The effect of intraoperative lidocaine infusion on opioid consumption and pain after totally extraperitoneal laparoscopic inguinal hernioplasty: a randomized controlled trial.

BMC Anesthesiol 2020 Jun 3;20(1):137. Epub 2020 Jun 3.

Department of Anesthesiology & Critical Care Medicine, BP Koirala Institute of Health Sciences, Dharan, Nepal.

Background: As a component of multimodal analgesia, the administration of systemic lidocaine is a well-known technique. We aimed to evaluate the efficacy of lidocaine infusion on postoperative pain-related outcomes in patients undergoing totally extraperitoneal (TEP) laparoscopies inguinal hernioplasty.

Methods: In this randomized controlled double-blind study, we recruited 64 patients to receive either lidocaine 2% (intravenous bolus 1. Read More

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http://dx.doi.org/10.1186/s12871-020-01054-2DOI Listing

A BEME systematic review of teaching interventions to equip medical students and residents in early recognition and prompt escalation of acute clinical deteriorations: BEME Guide No. 62.

Med Teach 2020 Jun 4:1-14. Epub 2020 Jun 4.

Medical Education Unit, National University of Singapore, Singapore.

Current educational interventions and teaching for acute deteriorations seem to address acute care learning in discreet segments. Technology enhanced and team training methodologies are in vogue though well studied in the nursing profession, teaching avenues for junior 'doctors in training' seem to be a lacuna. The BEME systematic review was designed to (1) appraise the existing published evidence on educational interventions that are intended for 'doctors in training' to teach early recognition and prompt escalation in acute clinical deteriorations (2) to synthesise evidence & to evaluate educational effectiveness. Read More

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http://dx.doi.org/10.1080/0142159X.2020.1763286DOI Listing

Clinical practice in the management of postoperative delirium by Chinese anesthesiologists: a cross-sectional survey designed by the European Society of Anaesthesiology.

J Int Med Res 2020 Jun;48(6):300060520927207

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Berlin, Germany.

Objective: In this survey, we assessed the current clinical management of postoperative delirium (POD) among Chinese anesthesiologists, after publishing the European POD guideline.

Methods: We administered an electronic survey, designed according to the European POD guideline. The survey was completed using mobile devices. Read More

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http://dx.doi.org/10.1177/0300060520927207DOI Listing

Biological applications of a turn-on bioluminescent probe for monitoring sulfite oxidase deficiency in vivo.

Eur J Med Chem 2020 May 23;200:112476. Epub 2020 May 23.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong, 250012, China. Electronic address:

Sulfites are widely used as preservative and antioxidant additives in food and drug. A non-invasive method for in vivo imaging of sulfite represents a powerful tool for estimating its potential effects in living organisms. Herein, we report the design, development, and application of sulfite bioluminescent probes (SBPs) for the analyte-specific detection of sulfite through sulfite-mediated intramolecular cleavage. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112476DOI Listing

Post-operative pain and psychological outcomes following minimally invasive pectus excavatum repair: A report from the Society for Pediatric Anesthesia Improvement Network.

Paediatr Anaesth 2020 Jun 3. Epub 2020 Jun 3.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, United States.

Background: Minimally invasive repair of pectus excavatum (MIRPE) is associated with less tissue trauma, however it may result in increased postoperative pain. Pain experience is a known risk factor for the development of post-traumatic stress symptoms, though there is little data on itsrelationship with long-term psychological outcomes following major surgery in pediatric patients.

Aims: In this study, we examined the relationship between immediate postoperative pain and psychological outcomes at two weeks and three months after discharge in a cohort of pediatric patients who underwentMIRPE. Read More

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http://dx.doi.org/10.1111/pan.13942DOI Listing

Pandemonium During the Pandemic: What is the Role of Health and Science Professionals?

Arq Bras Cardiol 2020 Jun;114(5):753-754

Division of Cardiology, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC - USA.

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http://dx.doi.org/10.36660/abc.20200320DOI Listing

Non-operating room anaesthesia and difficult airway management in a case of ectopic lingual thyroid planned for magnetic resonance imaging.

Indian J Anaesth 2020 Apr 28;64(4):343-345. Epub 2020 Mar 28.

Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

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http://dx.doi.org/10.4103/ija.IJA_728_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259406PMC

Venous air embolism during air arthrogram of hip in an infant with arthrogryposes multiplex congenita.

Indian J Anaesth 2020 Apr 28;64(4):341-343. Epub 2020 Mar 28.

Department of Anaesthesia and Critical Care, Indraprastha Apollo Hospital, New Delhi, India.

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http://dx.doi.org/10.4103/ija.IJA_658_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259413PMC

Air pollution: A new challenge for anaesthesiologists!

Indian J Anaesth 2020 Apr 28;64(4):333-337. Epub 2020 Mar 28.

Department of Onco-anaesthesia and Palliative Medicine, Dr. BRAIRCH, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.4103/ija.IJA_927_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259419PMC

Erector spinae plane block for breast oncological procedure as a surrogate to general anaesthesia: A retrospective study.

Indian J Anaesth 2020 Apr 28;64(4):328-333. Epub 2020 Mar 28.

Department of Anesthesia, Critical Care and Pain Management, Mahatma Gandhi Medical College and Hospital, RIICO Institutional Area, Sitapura, Rajasthan, India.

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http://dx.doi.org/10.4103/ija.IJA_858_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259416PMC

Correlation between thromboelastography and rotational thromboelastometry values in adult liver transplant recipients.

Indian J Anaesth 2020 Apr 28;64(4):286-291. Epub 2020 Mar 28.

Center for Liver and Biliary Sciences Anaesthesia and Critical Care, Max Super Speciality Hospital, New Delhi, India.

Background And Aims: Viscoelastic haemostatic assays (VHA) namely Thromboelastogram (TEG) and Rotational thromboelastometry (ROTEM) are used for global assessment of coagulopathy and guiding transfusion during living donor liver transplant (LDLT).We conducted a study to compare the interchangeability of the values obtained from these devices in patients with End stage liver disease (ESLD) undergoing LDLT.

Methods: In 76 patients undergoing LDLT, ROTEM and TEG were performed and assessed for interchangeability using Spearman Correlation. Read More

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http://dx.doi.org/10.4103/ija.IJA_762_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259407PMC

A randomised evaluation of intercostal block as an adjunct to epidural analgesia for post-thoracotomy pain.

Indian J Anaesth 2020 Apr 28;64(4):280-285. Epub 2020 Mar 28.

Division of Thoracic Surgery, Department of Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Background And Aims: Post-thoracotomy pain can be severe and disabling. The aim of this study was to examine the efficacy of intercostal nerve block when used as adjunct to thoracic epidural analgesia in patients undergoing posterolateral thoracotomy.

Methods: This was a parallel-group randomised patient and assessor-blinded study carried out at a tertiary-referral cancer center. Read More

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http://dx.doi.org/10.4103/ija.IJA_714_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259421PMC

Implementing a COVID19 airway management strategy for a provincial critical care and ground transport program.

CJEM 2020 Jun 3:1-5. Epub 2020 Jun 3.

Critical Care Nurse, Flight Nurse, Clinical Supervisor Nova Scotia EHS LifeFlight.

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http://dx.doi.org/10.1017/cem.2020.413DOI Listing

A Predictive Model for Pediatric Postoperative Respiratory Failure: A National Inpatient Sample Study.

J Intensive Care Med 2020 Jun 3:885066620928272. Epub 2020 Jun 3.

Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL, USA.

Study Objective: To identify risk factors for pediatric postoperative respiratory failure and develop a predictive model.

Design: This retrospective case-control study utilized the US National Inpatient Sample (NIS) from 2012 to 2014. Significant predictors were selected, and the predicted probability of pediatric postoperative respiratory failure was calculated. Read More

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http://dx.doi.org/10.1177/0885066620928272DOI Listing

Impact of Left Atrial Appendage Exclusion on Short Term Outcomes In Isolated Coronary Artery Bypass Graft Surgery.

Circulation 2020 Jun 3. Epub 2020 Jun 3.

Department of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

The objective of this study was to evaluate the impact of LAA exclusion on short term outcomes in patients with atrial fibrillation undergoing isolated coronary artery bypass graft (CABG) surgery. We queried the 2010-2014 National Readmissions Database (NRD) for patients who underwent coronary artery bypass graft repair with and without left atrial appendage ligation using ICD-9 procedure codes (ICD-9: 36.1xx). Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044642DOI Listing

Accuracy and precision of zero-heat-flux temperature measurements with the 3M™ Bair Hugger™ Temperature Monitoring System: a systematic review and meta-analysis.

J Clin Monit Comput 2020 Jun 2. Epub 2020 Jun 2.

Department of Anesthesia and Pain Management, Toronto General Hospital, UHN, Toronto, Canada.

Zero-heat-flux thermometers provide clinicians with the ability to continuously and non-invasively monitor body temperature. These devices are increasingly being used to substitute for more invasive core temperature measurements during surgery and in critical care. The aim of this review was to determine the accuracy and precision of zero-heat-flux temperature measurements from the 3M™ Bair Hugger™ Temperature Monitoring System. Read More

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http://dx.doi.org/10.1007/s10877-020-00543-6DOI Listing

Is there disparity between regions and facilities in surgical resident training in Japan? Insights from a national survey.

Surg Today 2020 Jun 2. Epub 2020 Jun 2.

Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Purpose: This study sought to assess the disparity between regions and facilities in surgical resident training in Japan via a national level needs-assessment.

Methods: A survey was sent to all 909 graduating residents of 2016. Residents trained in the six prefectures with a population of 7 million or more were included in the large prefecture (LP) group. Read More

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http://dx.doi.org/10.1007/s00595-020-02037-zDOI Listing

Analgesic Effectiveness of Perioperative Ultrasound-Guided Serratus Anterior Plane Block Combined with General Anesthesia in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Systematic Review and Meta-analysis.

Pain Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

Objective: To investigate whether perioperative ultrasound-guided serratus anterior plane block (SAPB) combined with general anesthesia is more effective and safer than current analgesic techniques for postoperative analgesia after video-assisted thoracoscopic surgery (VATS).

Methods: PubMed, the Cochrane Library, and EMBASE were searched for clinical trials published up to July 31, 2019. Outcomes, including operative duration, postoperative pain scores, postoperative analgesia use, patient satisfaction with analgesia, time to chest tube removal, length of stay, and adverse effects were analyzed. Read More

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http://dx.doi.org/10.1093/pm/pnaa125DOI Listing

Correction: Endostatin and ST2 are predictors of pulmonary hypertension disease course in infants.

J Perinatol 2020 Jun 2. Epub 2020 Jun 2.

Eudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41372-020-0700-7DOI Listing

Ten years of the Helsinki Declaration on patient safety in anaesthesiology: An expert opinion on peri-operative safety aspects.

Eur J Anaesthesiol 2020 Jun 1. Epub 2020 Jun 1.

From the Department of Anaesthesiology, Amsterdam University Medical Centers, Academic Medical Center (AMC), Amsterdam, The Netherlands (BP), Institute for Anaesthesia and Intensive Care Medicine, Spital Männedorf AG, Männedorf, Switzerland (SS), Department of Anaesthesiology, Perioperative Medicine and Intensive Care, Paracelsus Medical University Salzburg, Salzburg, Austria (SS), Department of Anaesthesiology and Critical Care, University Hospital Fundación Alcorcón Madrid, Spain (DA), Department of Anaesthesia and Intensive Care, Haukeland University Hospital (GB, ASH), Department of Clinical Medicine, University of Bergen, Bergen, Norway (GB), Department of Anesthesiology and Critical Care Medicine, Perelman School of Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA (JMF), Anaesthetic Department, St James's Hospital, Dublin, Ireland (RF-OC), Department of Anesthesiology & Critical Care, University de Lorraine, CHRU Nancy, Brabois University Hospital, Nancy, France (TF-B), Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA (SNG-F), Department of Anaesthesiology, Geneva University Hospitals, Geneva, Switzerland (GH), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia (GH), Department of Anesthesiology, Onze-Lieve-Vrouwziekenhuis Hospital Aalst, Aalst, Belgium (JFAH), Division of Anesthesiology, Intensive Care and Emergency Medicine, University Medical Center Utrecht, Utrecht, The Netherlands (CJK), Department of Anesthesiology, Intensive Care Medicine & Pain Therapy, University Hospital Frankfurt, Frankfurt (PM, KZ), Department of Anaesthesiology, University Hospital Würzburg, Würzburg (PM), Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany (CN), Copenhagen Academy for Medical Education and Simulation (DØ), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (DØ), Paediatric Intensive Care Unit, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK (AP), Product Management Anesthesiology, Drägerwerk AG & Co. KGaA, Lübeck, Germany (HUS), Department of Anaesthesia, Royal Lancaster Infirmary, Lancaster, UK (AFS), Department of Anaesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands (MMRFS), Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium (MMRFS), Department of Acute Medicine, Ysbyty Gwynedd Hospital, Bangor, UK (CPS), School of Medical Science, Bangor University, Bangor, UK (CPS), Institute of Anaesthesia and Intensive Care IFAI, Hirslanden Clinic, Zurich, Switzerland (JWa), Department of Critical Care, University College Hospital, London (JWe), Department of Anaesthesia, Manchester Royal Infirmary, Manchester, UK (DKW) and Department of Anaesthesia and Intensive Care Medicine, Baerum Hospital, Sandvika, Norway (JM-O).

: Patient safety is an activity to mitigate preventable patient harm that may occur during the delivery of medical care. The European Board of Anaesthesiology (EBA)/European Union of Medical Specialists had previously published safety recommendations on minimal monitoring and postanaesthesia care, but with the growing public and professional interest it was decided to produce a much more encompassing document. The EBA and the European Society of Anaesthesiology (ESA) published a consensus on what needs to be done/achieved for improvement of peri-operative patient safety. Read More

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http://dx.doi.org/10.1097/EJA.0000000000001244DOI Listing

Anesthesia for patients with psychiatric illnesses: a narrative review with emphasis on preoperative assessment and postoperative recovery and pain.

Minerva Anestesiol 2020 May 29. Epub 2020 May 29.

Military Medical Academy, Belgrade, Serbia -

The physical and psychological fragility of patients with psychiatric illness poses critical importance in the preoperative assessment, evaluation, and choice of premedication, which includes regular therapy, as well as concerns about polypharmacy with possible interactions of anesthetics, analgesics, and psychiatric medications. A considerable effort is to reduce risks for exacerbations or relapses of imminent illness in the postoperative period. In this narrative review, the goal was also set towards the use of proper tools for the preoperative assessment of anxiety and management of postoperative pain. Read More

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http://dx.doi.org/10.23736/S0375-9393.20.14259-7DOI Listing

Pathogenesis-Targeted Preventive Strategies for Multidrug Resistant Ventilator-Associated Pneumonia: A Narrative Review.

Microorganisms 2020 May 30;8(6). Epub 2020 May 30.

Department of Anesthesia and Intensive Care, University of Foggia, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Viale Pinto 241, 71122 Foggia, Italy.

Ventilator-associated pneumonia (VAP) is the most common hospital-acquired infection in the intensive care unit (ICU), accounting for relevant morbidity and mortality among critically ill patients, especially when caused by multidrug resistant (MDR) organisms. The rising problem of MDR etiologies, which has led to a reduction in treatment options, have increased clinician's attention to the employment of effective prevention strategies. In this narrative review we summarized the evidence resulting from 27 original articles that were identified through a systematic database search of the last 15 years, focusing on several pathogenesis-targeted strategies which could help preventing MDR-VAP. Read More

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http://dx.doi.org/10.3390/microorganisms8060821DOI Listing

Improved tracking of sevoflurane anesthetic states with drug-specific machine learning models.

J Neural Eng 2020 Jun 2. Epub 2020 Jun 2.

Massachusetts General Hospital, Boston, 02114-2696, UNITED STATES.

Objective: The ability to monitor anesthetic states using automated approaches is expected to reduce inaccurate drug dosing and side-effects. Commercially available anesthetic state monitors perform poorly when ketamine is administered as an anesthetic-analgesic adjunct. Poor performance is likely because the models underlying these monitors are not optimized for the electroencephalogram (EEG) oscillations that are unique to the co-administration of ketamine. Read More

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http://dx.doi.org/10.1088/1741-2552/ab98daDOI Listing

Anesthetic Management of Lung Transplantation: Results from a Multi-Center, Cross-Sectional Survey by the Society for Advancement of Transplant Anesthesia.

Clin Transplant 2020 Jun 2:e13996. Epub 2020 Jun 2.

Department of Anesthesiology, University of Colorado School of Medicine, Denver, CO, United States.

Background: Current protocols for the perioperative care of lung transplant (LTX) recipients lack rigorous evidence and are often empiric, based upon institutional preferences. We surveyed LTX anesthesiologists to determine the most common practices.

Methods: We developed a survey of 40 questions regarding perioperative care of LTX recipients using Qualtrics' software. Read More

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http://dx.doi.org/10.1111/ctr.13996DOI Listing

Frequency of hyperoxaemia during and after major surgery.

Anaesth Intensive Care 2020 Jun 2:310057X20905320. Epub 2020 Jun 2.

Department of Intensive Care, Austin Hospital, Melbourne, Australia.

The oxygen concentration (FiO) and arterial oxygen tension (PaO) delivered in patients undergoing major surgery is poorly understood. We aimed to assess current practice with regard to the delivered FiO and the resulting PaO in patients undergoing major surgery. We performed a retrospective cohort study in a tertiary hospital. Read More

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http://dx.doi.org/10.1177/0310057X20905320DOI Listing

Effects of Low-dose Propofol or Ketamine on Coughing at Emergence from Anesthesia in Children Undergoing Tonsillectomy.

Cureus 2020 Apr 26;12(4):e7842. Epub 2020 Apr 26.

Anesthesiology, Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, IRN.

Introduction Coughing is commonly observed during emergence from general anesthesia. In children, smooth emergence from anesthesia, especially after tonsillectomy, is crucial. In this study, we compared the effect of low-dose ketamine or propofol on emergence coughing in children undergoing tonsillectomy. Read More

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http://dx.doi.org/10.7759/cureus.7842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253079PMC

Impact of Personal Protective Equipment on Pediatric Cardiopulmonary Resuscitation Performance: A Controlled Trial.

Pediatr Emerg Care 2020 Jun;36(6):267-273

Feinberg School of Medicine, Northwestern University, Chicago, IL.

Objectives: This study aimed to determine whether personal protective equipment (PPE) results in deterioration in chest compression (CC) quality and greater fatigue for administering health care providers (HCPs).

Methods: In this multicenter study, HCPs completed 2 sessions. In session 1 (baseline), HCPs wore normal attire; in session 2, HCPs donned full PPE. Read More

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http://dx.doi.org/10.1097/PEC.0000000000002109DOI Listing

Integration of the Intrinsic Surgical Risk With Patient Comorbidities and Severity of Congenital Cardiac Disease Does Not Improve Risk Stratification in Children Undergoing Noncardiac Surgery.

Anesth Analg 2020 May 29. Epub 2020 May 29.

Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: The objective of this study is to estimate the surgical risk of noncardiac procedures on the incidence of 30-day mortality in children with congenital heart disease.

Methods: Children with congenital heart disease undergoing noncardiac surgery from 2012 to 2016 and included in the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) Pediatric database were included in the derivation cohort, while the 2017 database was used as a validation cohort. Intrinsic surgical risk quartiles were built utilizing 30-day mortality rates for each Current Procedural Terminology code and relative value units to create 2 groups defined as low surgical risk (quartiles 1-3) and high surgical risk procedures (quartile 4). Read More

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http://dx.doi.org/10.1213/ANE.0000000000004906DOI Listing

Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice.

Anesthesiology 2020 May 28. Epub 2020 May 28.

From the Department of Anesthesiology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (R.L., P.Z.) the Center for Brain Science, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (R.L.) the Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care (R.L., I.K.L., J.Z.P., M.M.) the Brain and Spinal Injury Center (J.Z.P.), University of California, San Francisco, California.

Background: Clinical studies have shown that dexmedetomidine ameliorates cognitive decline in both the postoperative and critical care settings. This study determined the mechanism(s) for the benefit provided by dexmedetomidine in a medical illness in mice induced by lipopolysaccharide.

Methods: Cognitive decline, peripheral and hippocampal inflammation, blood-brain barrier permeability, and inflammation resolution were assessed in male mice. Read More

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http://dx.doi.org/10.1097/ALN.0000000000003390DOI Listing

Ethical decision-making for children with neuromuscular disorders in the COVID-19 crisis.

Neurology 2020 Jun 1. Epub 2020 Jun 1.

Division of Pediatric Neurology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida

The sudden appearance and proliferation of COVID-19 has forced societies and governmental authorities across the world to confront the possibility of resource constraints when critical care facilities are overwhelmed by the sheer numbers of grievously ill patients. As governments and health care systems develop and update policies and guidelines regarding the allocation of resources, patients and families affected by chronic disabilities, including many neuromuscular disorders that affect children and young adults, have become alarmed at the possibility that they may be determined to have less favorable prognoses due to their underlying diagnoses and thus be assigned to lower priority groups. It is important for health care workers, policymakers, and government officials to be aware that the long term prognoses for children and young adults with neuromuscular disorders are often more promising than previously believed, due to a better understanding of the natural history of these diseases, benefits of multidisciplinary supportive care, and novel molecular therapies that can dramatically improve the disease course. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009936DOI Listing

The perils of premature phenotyping in COVID: a call for caution.

Eur Respir J 2020 Jun 1. Epub 2020 Jun 1.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1183/13993003.01768-2020DOI Listing

The Michigan Appropriateness Guide for Intravenous Catheters in Pediatrics: miniMAGIC.

Pediatrics 2020 Jun;145(Suppl 3):S269-S284

Patient Safety Enhancement Program and Center for Clinical Management Research, US Department of Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan.

Objectives: Vascular access device decision-making for pediatric patients remains a complex, highly variable process. To date, evidence-based criteria to inform these choices do not exist. The objective of the Michigan Appropriateness Guide for Intravenous Catheters in pediatrics (miniMAGIC) was to provide guidance on device selection, device characteristics, and insertion technique for clinicians, balancing and contextualizing evidence with current practice through a multidisciplinary panel of experts. Read More

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http://dx.doi.org/10.1542/peds.2019-3474IDOI Listing

Machine Learning and Artificial Intelligence in Pediatric Research: Current State, Future Prospects, and Examples in Perioperative and Critical Care.

J Pediatr 2020 Jun;221S:S3-S10

Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2020.02.039DOI Listing

Deletion of Perilipin 5 Protects Against Hepatic Injury in Nonalcoholic Fatty Liver Disease via Missing Inflammasome Activation.

Cells 2020 May 28;9(6). Epub 2020 May 28.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, 52074 Aachen, Germany.

Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver diseases with an increasing prevalence due to rising rates of obesity, metabolic syndrome and type II diabetes. Untreated NAFLD may progress to steatohepatitis (NASH) and ultimately liver cirrhosis. NAFLD is characterized by lipid accumulation, and when sufficient excess lipids are obtained, irreversible liver injury may follow. Read More

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http://dx.doi.org/10.3390/cells9061346DOI Listing

Direct Identification of Amyloid Peptide Fragments in Human α-Synuclein Based on Consecutive Hydrophobic Amino Acids.

ACS Omega 2020 May 12;5(20):11677-11686. Epub 2020 May 12.

Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Center and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.

Formation of amyloid fibrils by misfolding α-synuclein is a characteristic feature of Parkinson's disease, but the exact molecular mechanism of this process has long been an unresolved mystery. Identification of critical amyloid peptide fragments from α-synuclein may hold the key to decipher this mystery. Focusing on consecutive hydrophobic amino acids (CHAA) in the protein sequence, in this study we proposed a sequence-based strategy for direct identification of amyloid peptide fragments in α-synuclein. Read More

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http://dx.doi.org/10.1021/acsomega.0c00979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254785PMC

Graduate Midwifery Education in Uganda Aiming to Improve Maternal and Newborn Health Outcomes.

Ann Glob Health 2020 May 21;86(1):52. Epub 2020 May 21.

Seed Global Health, US.

Background: Maternal and newborn health outcomes in Uganda have remained poor. The major challenge affecting the implementation of maternal and newborn interventions includes a shortage of skilled midwives. In 2013, Lira University, a Ugandan Public University, in partnership with Seed Global Health, started the first Bachelor of Science in Midwifery (BScM) in Uganda with a vision to develop a Master of Science in Midwifery (MScM) in the future. Read More

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http://dx.doi.org/10.5334/aogh.2804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243829PMC

Developing and Implementing the Family Nurse Practitioner Role in Eswatini: Implications for Education, Practice, and Policy.

Ann Glob Health 2020 May 18;86(1):50. Epub 2020 May 18.

University of Massachusetts Boston, College of Nursing and Health Sciences, US.

Introduction: Eswatini, a small, largely rural country in Southern Africa, has a high burden of morbidity/mortality in the setting of a critical shortage of human resources for health. To help achieve universal access to healthcare across the lifespan, the advanced practice family nurse practitioner (FNP) role was proposed and is in the process of being implemented.

Methods/approach: The PEPPA framework (articipatory, vidence-based, atient focused rocess for dvanced practice nursing) illustrates the steps in the process of developing and implementing the FNP role in a country. Read More

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http://dx.doi.org/10.5334/aogh.2813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243836PMC

The Physiological Effect of 1MAC Sevoflurane with or without 50% Xenon in Immature Rats.

Paediatr Anaesth 2020 Jun 1. Epub 2020 Jun 1.

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, United Kingdom.

Anesthetic-induced neurodegenerationin rats occursacross the first three postnatal weeks (human equivalent:fetus to pre-schooler), during which the central nervous system, respiratory control and pharmacodynamics undergo hugechanges. In immature rats, hypercarbia alone(mimicking isoflurane anesthesia-induced hypercarbia) induced neurodegeneration and Xenon reducesanesthetic-induced neurodegeneration. Read More

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http://dx.doi.org/10.1111/pan.13933DOI Listing

A Conceptual Introduction to Regression.

Headache 2020 Jun;60(6):1047-1055

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/head.13834DOI Listing

Anesthesia residency training in regional anesthesiology and acute pain medicine: a competency-based model curriculum.

Reg Anesth Pain Med 2020 May 30. Epub 2020 May 30.

Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.

The Accreditation Council for Graduate Medical Education has shifted to competency-based medical education. This educational framework requires the description of educational outcomes based on the knowledge, skills and behaviors expected of competent trainees. It also requires an assessment program to provide formative feedback to trainees as they progress to competency in each outcome. Read More

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http://dx.doi.org/10.1136/rapm-2020-101480DOI Listing

Small bowel ischemia and SARS-CoV-2 infection: an underdiagnosed distinct clinical entity.

Surgery 2020 May 4. Epub 2020 May 4.

Department of Digestive and Endocrine Surgery, University Hospital of Strasbourg, France; IRCAD/IHU: Institute of Image-guided Surgery, Strasbourg, France.

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http://dx.doi.org/10.1016/j.surg.2020.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198136PMC

Combination of perineural dexamethasone and dexmedetomidine prolong analgesic duration of a supraclavicular block in a patient with complex regional pain syndrome.

J Clin Anesth 2020 May 27;65:109873. Epub 2020 May 27.

Portsmouth Anesthesia Associates, Anesthesiology and Pain Medicine, Portsmouth, VA, United States of America.

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http://dx.doi.org/10.1016/j.jclinane.2020.109873DOI Listing

Strategy of using personal protective equipment during aerosol generating medical procedures with COVID-19.

J Clin Anesth 2020 May 26;66:109911. Epub 2020 May 26.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 4-420, Boston, MA 02114, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.jclinane.2020.109911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247986PMC

Relationship between ACE-inhibitors, ARBs and SARS-CoV-2 infection: where are we?

Minerva Cardioangiol 2020 May 29. Epub 2020 May 29.

Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy.

SARS-CoV-2 is spreading rapidly all over the world. The case fatality rate seems higher in cardiovascular disease and hypertension. Other comorbidities do not seem to confer the same risk, therefore the understanding of the relationship between infection and cardiovascular system could be a crucial point for the fight against the virus. Read More

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http://dx.doi.org/10.23736/S0026-4725.20.05271-8DOI Listing