1,884 results match your criteria Anaerobe[Journal]


Antibiotic susceptibility testing of anaerobic bacteria by broth microdilution method using the MICRONAUT-S Anaerobes MIC plates.

Anaerobe 2020 May 24:102217. Epub 2020 May 24.

University Hospital of Bologna-Policlinico Sant'Orsola-Malpighi, Operative Unit of Microbiology, via Massarenti, 9, Bologna, Italy.

Susceptibility profiles of anaerobic bacteria to antibiotics have become unpredictable, thus reliable and user-friendly methods for routine susceptibility testing are needed. In this study, we evaluated the MICRONAUT-S Anaerobes MIC test plate, a commercially available broth microdilution method, and suitable for clinical microbiology routine testing. We analyzed a collection of 300 consecutive clinically significant isolates, including 149 Gram-positive and 151 Gram-negative strains. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102217DOI Listing

The effect of intervention by an antimicrobial stewardship team on anaerobic bacteremia.

Anaerobe 2020 May 21:102214. Epub 2020 May 21.

Department of Infection Control Science, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, Osaka-shi, Osaka, 545-8585, Japan; Department of Infection Control and Prevention, Osaka City University Hospital, 1-4-3, Asahi-machi, Abeno-ku, Osaka-shi, Osaka, 545-8585, Japan; Research Center for Infectious Diseases, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, Osaka-shi, Osaka, 545-8585, Japan. Electronic address:

The effect of antimicrobial stewardship (AS) on anaerobic bacteremia is uncertain. This study aimed to assess the effect of interventions by the AS team (AST) on clinical and microbiological outcomes and antimicrobial use. An AS program was introduced at Osaka City University Hospital in January 2014; an interdisciplinary AST was established. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102214DOI Listing

Clostridioides difficile proline fermentation in response to commensal clostridia.

Anaerobe 2020 May 15;63:102210. Epub 2020 May 15.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.

Clostridioides difficile colonizes the intestines of susceptible individuals and releases toxins that mediate disease. To replicate and expand in the intestines, C. difficile ferments proline, and this activity is influenced by the availability of proline and trace nutrients. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102210DOI Listing

A Hungatella effluvii isolate in blood culture of a patient with hematochezia.

Anaerobe 2020 May 15;63:102211. Epub 2020 May 15.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Laboratory Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea. Electronic address:

Hungatella spp. are anaerobic bacteria, are known members of the gut microbiome and very rarely cause human infection. Hungatella effluvii was isolated from an effluent treatment plant in 2014. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102211DOI Listing

Multilocus sequence typing of Clostridium perfringens strains from neonatal calves, dairy workers and associated environment in India.

Anaerobe 2020 May 13;63:102212. Epub 2020 May 13.

Division of Bacteriology and Mycology, Indian Council for Agricultural Research (ICAR)- Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, Uttar Pradesh, India. Electronic address:

Clostridium perfringens is a globally recognized zoonotic pathogen. We report isolation and genotyping of C. perfringens from neonatal calves, dairy workers and their associated environment in India. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102212DOI Listing

Putative serum protein biomarkers for epsilon toxin exposure in mouse model using LC-MS/MS analysis.

Anaerobe 2020 May 6;63:102209. Epub 2020 May 6.

Biotechnology Division, Defence Research & Development Establishment, Gwalior, 474002, India. Electronic address:

Epsilon toxin (ETX), produced by Clostridium perfringens Type B or type D strains, is a potential biological and toxin warfare (BTW) agent, largely for its very high toxicity. The toxin is implicated in several animal diseases. Using LC-MS/MS analysis, we report here elucidation of putative serum maker proteins for ETX exposure with an objective of the early diagnosis of intoxication. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102209DOI Listing
May 2020
2.479 Impact Factor

Characterization of sporulation dynamics of Pseudoclostridium thermosuccinogenes using flow cytometry.

Anaerobe 2020 May 6;63:102208. Epub 2020 May 6.

Corbion, Arkelsedijk 46, 4206 AC, Gorinchem, the Netherlands; Laboratory of Microbiology, Wageningen University and Research, 6708 WE, Wageningen, the Netherlands. Electronic address:

Single-cell analysis of microbial population heterogeneity is a fast growing research area in microbiology due to its potential to identify and quantify the impact of subpopulations on microbial performance in, for example, industrial biotechnology, environmental biology, and pathogenesis. Although several tools have been developed, determination of population heterogenity in anaerobic bacteria, especially spore-forming clostridia species has been amply studied. In this study we applied single cell analysis techniques such as flow cytometry (FCM) and fluorescence-assisted cell sorting (FACS) on the spore-forming succinate producer Pseudoclostridium thermosuccinogenes. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102208DOI Listing

Epidemiologic trends in Clostridioides difficile isolate ribotypes in United States from 2011 to 2016.

Anaerobe 2020 May 6;63:102185. Epub 2020 May 6.

Montana State University, Bozeman, MT, USA.

Background: Geographic and temporal trends in the distribution of PCR ribotypes for Clostridioides difficile associated diarrheal isolates obtained in the United States (US) are changing. As part of a US national surveillance program of C. difficile susceptibility to fidaxomicin, we quantified the distribution of PCR ribotypes of stool isolates collected from 2011 to 2016. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102185DOI Listing

Epidemiology and microbiological features of anaerobic bacteremia in two French University hospitals.

Anaerobe 2020 Apr 28:102207. Epub 2020 Apr 28.

Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France; UMR MIVEGEC IRD-CNRS-Université de Montpellier, IRD, Montpellier, France.

Bacteremia implicating anaerobic bacteria (BIAB) represents 2-6% of all episodes of bacteremia and is associated with high mortality. In this retrospective study from June 2015 to December 2016, we compared BIAB frequency in two hospital centers in Montpellier (France): Montpellier university hospital (MUH) and a center specialized in cancer (ICM). Among the 2465 microbiologically relevant episodes of bacteremia, we identified 144 (5. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102207DOI Listing

A comparative study on the use of selective media for the enumeration of Clostridium perfringens in poultry faeces.

Anaerobe 2020 Apr 27;63:102205. Epub 2020 Apr 27.

Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium. Electronic address:

Isolation and fast detection of Clostridium perfringens is essential in veterinary medical diagnostics and veterinary research, as it allows to recommend suitable treatment options after antimicrobial resistance determination, and is essential to study pathogenesis. In this study four selective media were tested for the enumeration of, and selectivity towards C. perfringens in faecal samples from poultry. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102205DOI Listing

A child with recurrent otitis media due to Bacteroides thetaiotaomicron.

Anaerobe 2020 Apr 25;63:102203. Epub 2020 Apr 25.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Brain abscess remains a life-threatening condition. Here, we are reporting a case of brain abscess due to Bacteroides thetaiotaomicron in a previously known case of recurrent otitis media. A 15 years old boy with a history of recurrent otitis media presented with the complaints of right otalgia, headache and fever. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102203DOI Listing

Bacteria producing antimicrobials against Clostridium difficile isolated from human stool.

Anaerobe 2020 Apr 25;63:102206. Epub 2020 Apr 25.

Microbiology and Immunology Department, Faculty of Pharmacy, Cairo University, Kasr Al-Aini, 11562, Cairo, Egypt.

Clostridium difficile infection (CDI) is a common cause of morbidity and mortality in hospitalized patients worldwide. The major problem facing current treatment is multiple recurrences, prompting the need for alternative therapies. In this study we isolated bacterial species, from Egyptian individuals' stool, with antimicrobial activity against clinical isolates of C. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102206DOI Listing
April 2020
2.479 Impact Factor

Role of Clostridioides difficile in hospital environment and healthcare workers.

Anaerobe 2020 Apr 24;63:102204. Epub 2020 Apr 24.

Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid (UCM), Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; CIBER de Enfermedades Respiratorias (CIBERES CB06/06/0058), Madrid, Spain.

Clostridioides difficile infection (CDI) was traditionally considered to be transmitted within healthcare environment, from other patients or healthcare workers (HCW). Recently, this idea has been challenged. Our objective was to determine the extent of C. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102204DOI Listing

Screening of BHK-21 cellular proteins that interact with outer membrane protein 43K OMP of Fusobacterium necrophorum.

Anaerobe 2020 Mar 4;63:102184. Epub 2020 Mar 4.

Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China. Electronic address:

Fusobacterium necrophorum is a Gram negative, spore-free, anaerobic bacterium that can cause pyogenic and necrotic infections in animals and humans. It is a major bovine pathogen and causes hepatic abscesses, foot rot, and necrotic laryngitis. The 43K OMP of F. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102184DOI Listing

Recombinant vaccine against botulism in buffaloes: Evaluation of the humoral immune response over 12 months.

Anaerobe 2020 Apr 2;63:102201. Epub 2020 Apr 2.

Instituto de Medicina Veterinária, Universidade Federal do Pará, BR 316 Km 61, Saudade II, Cristo Redentor, Castanhal, 68740-910, PA, Brazil. Electronic address:

Botulism is a neuroparalytic intoxication, usually fatal, caused by the botulinum toxins (BoNTs). Vaccination is the best-known strategy to prevent this disease in ruminants. Serotypes C and D and their variants CD and DC are the main types responsible for botulism in bovine and buffaloes in Brazil and cattle in Japan and Europe. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102201DOI Listing

Anaerobic blood culture positivity at a University Hospital in Hungary: A 5-year comparative retrospective study.

Anaerobe 2020 Apr 1;63:102200. Epub 2020 Apr 1.

Department of Public Health, Faculty of Medicine, University of Szeged, 6720 Szeged, Dóm tér 10, Szeged, Hungary. Electronic address:

Anaerobic bacteremia (AB) is usually detected in about 0.5-13% of positive blood cultures. The aim of this study was to determine prevalence of anaerobic bacteremia over a 5-year period (2013-2017), to identify current trends at our University Hospital and to compare the results to those in a similar study (2005-2009) in the same region. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102200DOI Listing

Clinical relevance of Clostridium bacteremia: An 8-year retrospective study.

Anaerobe 2020 Apr 1;63:102202. Epub 2020 Apr 1.

Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France; CHU Lille, Service de Bactériologie-Hygiène, F-59000, Lille, France. Electronic address:

Clostridium spp. are recovered from 25% of the blood culture positive with anaerobes. However, the clinical relevance of Clostridium bacteremia has been controverted in the literature, particularly for C. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102202DOI Listing
April 2020
2.479 Impact Factor

Bacteremia due to a toxin A-negative, B-positive Clostridioides difficile ribotype 017 strain.

Anaerobe 2020 Mar 28;63:102195. Epub 2020 Mar 28.

Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.

Clostridioides difficile is the leading cause of healthcare-associated diarrhea. Although the incidence of C. difficile-associated diarrhea is increasing worldwide, bacteremia due to C. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102195DOI Listing

Antibacterial activity of salvia officinalis L. against periodontopathogens: An in vitro study.

Anaerobe 2020 Mar 20;63:102194. Epub 2020 Mar 20.

Laboratory of Research in Applied Microbiology, University of Franca, Franca, SP, Brazil; Laboratory of Antimicrobial Trials (LEA), Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, MG, Brazil. Electronic address:

Being aware of the remarkable antimicrobial potential of S. officinalis L., we aimed to evaluate the antimicrobial activity of the S. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102194DOI Listing

Isolation of Clostridioides difficile from different outdoor sites in the domestic environment.

Anaerobe 2020 Apr 3;62:102183. Epub 2020 Mar 3.

National Laboratory for Health, Environment and Food, NLZOH, Slovenia; Medical Faculty, University of Maribor, Slovenia. Electronic address:

Clostridioides difficile was isolated from 12 of 25 samples collected from the gardens of five individual houses and 132 isolates belonged to 12 PCR ribotypes. Compost material had the highest positivity rate and the highest PCR ribotype diversity in comparison to soil from vegetable and flower gardens. Isolated PCR ribotypes overlap with common human and animal types but also with divergent C. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102183DOI Listing

Isolation of Clostridium perfringens and Clostridioides difficile in diarrheic and nondiarrheic cats.

Anaerobe 2020 Apr 21;62:102164. Epub 2020 Jan 21.

Veterinary School, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos, 6627, Belo Horizonte, MG, CEP 31.270-901, Brazil.

The occurrence and characteristics of Clostridioides (previously Clostridium) difficile and Clostridium perfringens in the feces of diarrheic and non-diarrheic cats was investigated. Apparently healthy animals were more likely to be positive for C. perfringens type A (p = 0. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102164DOI Listing

A Europe-wide assessment of antibiotic resistance rates in Bacteroides and Parabacteroides isolates from intestinal microbiota of healthy subjects.

Anaerobe 2020 Apr 29;62:102182. Epub 2020 Feb 29.

Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.

Here, we sought to assess the levels of antibiotic resistance among intestinal Bacteroides and Parabacteroides strains collected between 2014 and 2016 in Europe and also attempted to compare resistance levels between clinical and commensal isolates. Bacteroides and Parabacteroides isolates were recovered from faecal samples via the novel Bacteroides Chromogenic Agar (BCA) method. Antibiotic susceptibilities were determined by agar dilution for ten antibiotics. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102182DOI Listing

Surveillance of antimicrobial susceptibilities reveals high proportions of multidrug resistance in toxigenic Clostridium difficile strains in different areas of Poland.

Anaerobe 2020 Apr 13;62:102167. Epub 2020 Feb 13.

Department of Medical Microbiology, Medical University of Warsaw, Poland.

Two hundred and fifty-three non-duplicate toxigenic Clostridium difficile isolates, collected from February 2012 to December 2014, were evaluated for phenotypic resistance to ten antimicrobial drugs with the E-test gradient diffusion method. All strains of C. difficile were susceptible to metronidazole, vancomycin, and tigecycline. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102167DOI Listing

Antibiotic resistance, genome analysis and further safe traits of Clostridium perfringens ICVB082; a strain capable of producing an inhibitory compound directed only against a closely related pathogenic strain.

Anaerobe 2020 Apr 15;62:102177. Epub 2020 Feb 15.

Université Lille, INRA, ISA, Université d'Artois, Université Littoral Côte d'Opale, EA 7394-ICV Institut Charles Viollette, F-59000, Lille, France. Electronic address:

Eleven strains of clostridia were isolated from chickens suffering from necrotic enteritis (NE) disease, and were identified by 16S rDNA sequencing as C. perfringens (Clin1, ICVB079, ICVB080, ICVB081, ICVB082, ICVB083, ICVB085, ICVB088, ICVB089, ICVB090), C. sporogenes (ICVB086) and C. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102177DOI Listing

Factors affecting reported Clostridioides difficile infection rates; the more you look the more you find, but should you believe what you see?

Anaerobe 2020 Apr 22;62:102178. Epub 2020 Feb 22.

Healthcare Associated Infections Research Group, University of Leeds, Leeds, UK.

Reported rates of C. difficile infection (CDI) have increased in many settings; however, these can be affected by factors including testing density (test-density) and diagnostic methods. We aimed to describe the impact of multiple factors on CDI rates. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102178DOI Listing

Characterization of Clostridioides difficile strains isolated from manure and digestate in five agricultural biogas plants.

Anaerobe 2020 Apr 21;62:102180. Epub 2020 Feb 21.

National Reference Laboratory for Clostridium difficile, Saint-Antoine Hospital, Assistance Publique- Hôpitaux de Paris, 34 rue Crozatier, 75012, Paris, France; UMR INSERM S-1139, Faculté de Pharmacie de Paris, Université de Paris, France.

Clostridioides difficile strains were isolated from manure and digestate samples from five biogas plants in France. The objective of this study was to characterize these isolates using PCR ribotyping, wgMLST, a multiplex PCR targeting genes encoding for the main virulence factors, i.e. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102180DOI Listing

Commercial probiotic cell-free supernatants for inhibition of Clostridium perfringens poultry meat infection in Egypt.

Anaerobe 2020 Apr 21;62:102181. Epub 2020 Feb 21.

Food Science Department, Faculty of Agriculture Saba Basha, Alexandria University, Alexandria, Egypt.

Prevalence of C. perfringens in Egyptian poultry causes severe economic losses in poultry industry which evokes innovative solutions for enhanced future prospects. The objective of this study was to employ probiotic cell-free supernatants for inhibition of Clostridium perfringens in poultry meat to control its prevalence in the Egyptian market. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102181DOI Listing
April 2020
2.479 Impact Factor

Anaerobe editorial office.

Authors:

Anaerobe 2020 Feb;61:102171

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http://dx.doi.org/10.1016/j.anaerobe.2020.102171DOI Listing
February 2020

β-Lactam resistance development affects binding of penicillin-binding proteins (PBPs) of Clostridium perfringens to the fluorescent penicillin, BOCILLIN FL.

Anaerobe 2020 Apr 20;62:102179. Epub 2020 Feb 20.

Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 71602, USA. Electronic address:

Alteration in the binding of bacterial penicillin-binding proteins (PBPs) to β-lactams is important in the development of drug resistance. The PBPs of wild type Clostridium perfringens ATCC 13124 and three β-lactam-resistant mutants were compared for the ability to bind to a fluorescent penicillin, BOCILLIN FL. The binding of the high molecular weight protein PBP1, a transpeptidase, to BOCILLIN FL was reduced in all of the resistant strains. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102179DOI Listing

Surveillance of antimicrobial resistance in recent clinical isolates of Gram-negative anaerobic bacteria in a Greek University Hospital.

Anaerobe 2020 Apr 7;62:102173. Epub 2020 Feb 7.

Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Crete, Greece.

The aim of our study was to determine the antimicrobial susceptibility profiles of 267 Gram-negative clinically significant anaerobes, isolated between October 2016 and October 2019, in a Greek university hospital. The species identification was performed by conventional methods and using the Vitek 2 automated system. Antimicrobial susceptibility testing to determine the MICs was performed by the E-test method. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102173DOI Listing

Susceptibility of Cutibacterium acnes to topical minocycline foam.

Anaerobe 2020 Apr 28;62:102169. Epub 2020 Jan 28.

Foamix Pharmaceuticals, Inc., Bridgewater, NJ, USA. Electronic address:

FMX101 4% minocycline foam (FMX101 4%) is a novel, topical minocycline formulation for treatment of acne vulgaris. We report that FMX101 4% had an MIC of 0.25 μg/ml and was ≥4-fold more active than comparator antimicrobials against a panel of 98 clinical Cutibacterium acnes isolates. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102169DOI Listing

Postpartum Fusobacterium gonidiaformans bacteremia.

Anaerobe 2020 Apr 28;62:102168. Epub 2020 Jan 28.

We present a case of a healthy 29 year-old female with an uneventful vaginal delivery who had transient, sudden onset of rigors and fever 36 hours postpartum. She was found to have Fusobacterium gonidiaformans bacteremia due to retained placental tissue. We report this organism as it is not well-described and rarely reported. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102168DOI Listing

Glutathione catabolism by Treponema denticola impacts its pathogenic potential.

Anaerobe 2020 Apr 7;62:102170. Epub 2020 Feb 7.

Department of Microbiology, Immunology and Molecular Genetics, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA. Electronic address:

Treponema denticola is a spirochete that is etiologic for periodontal diseases. This bacterium is one of two periodontal pathogens that have been shown to have a complete three step enzymatic pathway (GTSP) that catabolizes glutathione to HS. This pathway may contribute to the tissue pathology seen in periodontitis since diseased periodontal pockets have lower glutathione levels than healthy sites with a concomitant increase in HS concentration. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153967PMC

Comments on the published systematic review and meta-analysis on the increasing antibiotic resistance in Clostridioides difficile.

Anaerobe 2020 02 20;61:102141. Epub 2020 Jan 20.

Department of Microbiology, Faculty of Biology, Shahid Beheshti University, Tehran, Iran; Department of Molecular Biology, Cancer Biomedical Center (CBC), Tehran, Iran.

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http://dx.doi.org/10.1016/j.anaerobe.2019.102141DOI Listing
February 2020

Strong antimicrobial activity of collinin and isocollinin against periodontal and superinfectant pathogens in vitro.

Anaerobe 2020 Apr 21;62:102163. Epub 2020 Jan 21.

Periodontal Medicine Research Group, School of Dentistry, Universidad del Valle, 760043, Cali, Colombia. Electronic address:

Periodontitis pathogenesis involves activation of host immune responses triggered by microbial dysbiosis. Therefore, controlling periodontal pathogens in-vivo is a main goal of periodontal therapy. New antimicrobials might help to control periodontal infection and improve treatment outcomes at "the dark times" of increasing antibiotic resistance. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102163DOI Listing

A rare case of bacteremia caused by Propionibacterium (Propionimicrobium) lymphophilum.

Anaerobe 2020 Apr 25;62:102166. Epub 2020 Jan 25.

Department of Microbiology and Instituto de Investigación Biosanitaria ibs.GRANADA, University Hospital Virgen de las Nieves, Granada, Spain.

Propionibacterium (Propionimicrobium) lymphophilum is a Gram-positive anaerobic rod involved in few human diseases. We report a rare case of bacteremia due to this microorganism in an elderly patient. A 95-year-old woman without a remarkable medical history presented with dyspnea, chest pain and fever for seven days. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102166DOI Listing

Clostridioides difficile ribotype 106: A systematic review of the antimicrobial susceptibility, genetics, and clinical outcomes of this common worldwide strain.

Anaerobe 2020 Apr 19;62:102142. Epub 2019 Dec 19.

The University of Houston College of Pharmacy, Houston, TX, USA. Electronic address:

Clostridioides difficile typing is invaluable for the investigation of both institution-specific outbreaks as well as national surveillance. While the epidemic ribotype 027 (RT027) has received a significant amount of resources and attention, ribotype 106 (RT106) has become more prevalent throughout the past decade. The purpose of this systematic review was to comprehensively summarize the genetic determinants, antimicrobial susceptibility, epidemiology, and clinical outcomes of infection caused by RT106. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.102142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153973PMC

Fusobacterium bloodstream infections: A literature review and hospital-based case series.

Anaerobe 2020 Apr 28;62:102165. Epub 2020 Jan 28.

Infectious Diseases Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Infections with Fusobacterium, an anaerobic bacterium, have various clinical presentations, including bacteremia and Lemierre syndrome. Here, we report a case series of Fusobacterium bacteremia (FBB) from the largest academic center in Riyadh, Saudi Arabia, and provide a review of cases in the available literature.

Method: Records were retrospectively reviewed for all patients with at least one blood culture positive for Fusobacterium spp. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102165DOI Listing

Sonicate fluid inoculated into blood culture bottles does not improve diagnosis of periprosthetic joint infection caused by anaerobes. A retrospective analysis.

Anaerobe 2020 Apr 28;62:102152. Epub 2020 Jan 28.

Marienkrankenhaus, Division of Orthopedics, Aachen, Germany.

Background: In microbiological diagnosis of periprosthetic joint infection (PJI) there is much controversial discussion about culture media and incubation time, especially if anaerobic bacteria are the causative agents. This retrospective analysis was conducted to compare the results obtained by inoculation of sonicate fluid from prosthetic components into BD Bactec blood culture bottles with those obtained by our culture method using sensitive supplemented growth media.

Methods: Twenty-eight cases were included in this study. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102152DOI Listing

Activity of delafloxacin versus that of levofloxacin against anaerobic and microaerophilic isolates.

Anaerobe 2020 Apr 24;62:102150. Epub 2020 Jan 24.

Department of Medical Microbiology, Medical University of Sofia, 1431, Sofia, Bulgaria.

The aim of the study was to comparatively assess delafloxacin and levofloxacin activities against 96 anaerobic and some microaerophilic isolates. Delafloxacin minimal inhibitory concentrations (MICs) were strikingly lower than those of levofloxacin. Delafloxacin MIC against clostridia, other Gram-positive rods, anaerobic/microaerophilic cocci and Gram-negative rods were 0. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102150DOI Listing

Response to 'Comments on the published systematic review and meta-analysis on the increasing antibiotic resistance in Clostridioides difficile' by Kouhsari et al.

Anaerobe 2020 02 20;61:102148. Epub 2020 Jan 20.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.anaerobe.2020.102148DOI Listing
February 2020

Biofunctionalized zinc peroxide nanoparticles inhibit peri-implantitis associated anaerobes and Aggregatibacter actinomycetemcomitans pH-dependent.

Anaerobe 2020 Apr 18;62:102153. Epub 2020 Jan 18.

Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology and Preventive Dentistry, RWTH Aachen University, Aachen, Germany. Electronic address:

For dental implants the accumulation of anaerobic bacteria is a main reason for peri-implant inflammation, which untreated can lead to implant loss. Oxygen releasing substances may act as antibacterial agents. In this study glucose-1-phosphate (Glc-1P) biofunctionalized zinc peroxide (ZnO₂) nanoparticles of four different synthesis ratio (1-10:1) and sizes (4-5 nm) were tested against the anaerobes Fusobacterium nucleatum, Porphyromonas gingivalis, and Prevotella intermedia, as well as against Aggregatibacter actinomycetemcomitans, Enterococcus faecalis, Staphylococcus aureus, Lactobacillus paracasei, and the yeast Candida albicans. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102153DOI Listing

Proteogenomic analysis of the Clostridium difficile exoproteome reveals a correlation between phylogenetic distribution and virulence potential.

Anaerobe 2020 Apr 13;62:102151. Epub 2020 Jan 13.

Centro de Investigación en Enfermedades Tropicales and Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

C. difficile induces antibiotic-associated diarrhea due to the action of two secreted toxins, TcdA and TcdB. A considerable range of virulence among C. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102151DOI Listing

Effect of antibiotic to induce Clostridioides difficile-susceptibility and infectious strain in a mouse model of Clostridioides difficile infection and recurrence.

Anaerobe 2020 Apr 12;62:102149. Epub 2020 Jan 12.

Millennium Nucleus in the Biology of Intestinal Microbiota, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile; Microbiota-Host Interactions & Clostridia Research Group, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile. Electronic address:

The anaerobic bacterium Clostridioides difficile is the leading cause of antibiotic-associated diarrhea that can culminate in life-threating colitis. During the C. difficile infection (CDI), C. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102149DOI Listing

Inhibition of Bacteroidetes and Firmicutes by select phytochemicals.

Anaerobe 2020 Feb 24;61:102145. Epub 2019 Dec 24.

USDA Agricultural Research Service Forage-Animal Production Research Unit, Lexington, KY, USA; Department of Animal and Food Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA. Electronic address:

Current research indicates that changes in gut microbiota can impact the host, but it is not always clear how dietary and environmental factors alter gut microbiota. One potential factor is antimicrobial activity of compounds ingested by the host. The goal of this study was to determine the antimicrobial activity of common plant secondary metabolites against pure cultures of paired, structurally and phylogenetically distinct gastrointestinal bacteria of human or bovine origin: Prevotella bryantii B4, Bacteroides fragilis 25285, Acetoanaerobium (Clostridium) sticklandii SR and Clostridioides difficile 9689. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.102145DOI Listing
February 2020

Extraintestinal Clostridium difficile infection: Scrotal abscess.

Anaerobe 2020 Feb 28;61:102147. Epub 2019 Dec 28.

Division of Infectious Diseases, Department of Internal Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA. Electronic address:

Clostridium difficile infection is one of the most common causes of healthcare-associated morbidity and mortality. ExtraintestinalC. difficile infection is extremely rare; though a variety of infections involving different organs have been reported. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.102147DOI Listing
February 2020

A population-based study of the incidence of laboratory-confirmed Clostridium difficile infections and their recurrence in the Italian province of Udine.

Authors:
Francesca Valent

Anaerobe 2020 Feb 23;61:102144. Epub 2019 Dec 23.

Institute of Hygiene and Clinical Epidemiology, University Hospital of UdineSOC Istituto di Igiene Ed Epidemiologia Clinica, Azienda Sanitaria Universitaria Integrata di Udine, Via Colugna 50, 33100, Udine, Italy. Electronic address:

Clostridium difficile infections (CDI) are a frequent cause of healthcare-associated infection and are also increasingly described in the outpatient setting. Epidemiological data in Italy have been collected through hospital-based study designs. We aimed at studying the epidemiology of laboratory-confirmed CDI through a population-based analysis in the Italian 500,000-inhabitant province of Udine. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.102144DOI Listing
February 2020

Effects of supplemental plant oils on rumen bacterial community profile and digesta fatty acid composition in a continuous culture system (RUSITEC).

Anaerobe 2020 Feb 19;61:102143. Epub 2019 Dec 19.

Instituto de Ganadería de Montaña (CSIC-Universidad de León), Departamento de Producción Animal, Universidad de León, E-24007, León, Spain. Electronic address:

Lipid supplementation of ruminant diets may trigger changes in the ruminal microbiota and in anaerobic digestion. Changes in the bacterial community composition and in the fatty acid hydrogenation caused by the addition of different supplemental plant oils to a high concentrate diet were investigated in vitro using RUSITEC (rumen simulation technique) fermenters. The control (CTR) diet was a high-concentrate total mixed ration for dairy sheep, with no supplementary oil. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.102143DOI Listing
February 2020

In vitro and in vivo anti-clostridial activity of newly isolated Pediococcus acidilactici SPM138 against Clostridium difficile.

Anaerobe 2020 Feb 27;61:102146. Epub 2019 Dec 27.

College of Pharmacy, Sahmyook University, Seoul, 01795, South Korea. Electronic address:

Clostridium difficile infection (CDI) has become a growing health concern, as evident from the increase in the mortality rate among elderly or hospitalized patients. Treatment of CDI is usually based on antibiotics (metronidazole and vancomycin), but it has some limitations, including cost and antibiotic resistance. Probiotics could offer an effective remedy to prevent CDI and could be an auxiliary agent in treatment CDI. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.102146DOI Listing
February 2020

Uncovering Akkermansia muciniphila resilience or susceptibility to different temperatures, atmospheres and gastrointestinal conditions.

Anaerobe 2020 Feb 14;61:102135. Epub 2019 Dec 14.

Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.

Data regarding Akkermansia muciniphila viability under stress remains scarce despite its beneficial potential. Therefore, the main goal was to assess A. muciniphila culturability when exposed to different temperatures, atmospheres and gastrointestinal simulated conditions. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.102135DOI Listing
February 2020