3,654 results match your criteria Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology[Journal]


Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents.

Molecules 2018 Nov 29;23(12). Epub 2018 Nov 29.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.

With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (⁻) were synthesized and characterized. Due to thione-thiol tautomerism in the intermediate compound , type of substitution reaction in the final step was determined by two-dimensional (2D) NMR. In vitro antifungal activity of the synthesized compounds was evaluated against eight species. Read More

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November 2018

Cytokine Profile, Apoptosis, Glucocorticoid Receptor, and P-glycoprotein Expression Before and After Megadose Methylprednisolone Treatment in Children With Acute Immune Thrombocytopenia.

J Pediatr Hematol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Department of Hematology, Anadolu Sağlik Merkezi (Private Hospital/In affiliation with Johns Hopkins Medicine), Gebze, Turkey.

Objective: Immune thrombocytopenia (ITP) is an autoimmune disease, and it has become evident that T lymphocytes play an important role in the pathogenesis of ITP. We investigated the role of T helper (Th) intracellular IL-2, IL-4, IL-6, IFN-γ, and T lymphocyte apoptosis in the pathogenesis of acute ITP and the effect of glucocorticoid treatment on cytokine profile. We investigated also P-glycoprotein (P-gp) and glucocorticoid receptor (GCR) expression as a possible mechanism for glucocorticoid resistance. Read More

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November 2018

Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors.

Bioorg Chem 2018 Nov 17;84:41-50. Epub 2018 Nov 17.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.

In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, H NMR, C NMR and mass spectroscopies. The inhibitory potency of synthesized compounds was investigated towards acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidases A and B (MAO-A and MAO-B) enzymes. Read More

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November 2018
1 Read

PT symmetry protected non-Hermitian topological systems.

Authors:
C Yuce Z Oztas

Sci Rep 2018 Nov 27;8(1):17416. Epub 2018 Nov 27.

Department of Physics, Eskisehir Technical University, Eskisehir, 26555, Turkey.

We study PT symmetry protected topological phase in non-Hermitian 1D and 2D systems. We show that topological phase exist in non-Hermitian PT symmetric systems for both gapped and gapless systems and discuss appearance of exceptional points. We apply our formalism to a complex extension of the SSH model, topological semimetals and nodal superconductors. Read More

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November 2018

Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes.

Arch Pharm (Weinheim) 2018 Dec 27;351(12):e1800263. Epub 2018 Nov 27.

Faculty of Science, Department of Chemistry, Ataturk University, Erzurum, Turkey.

Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase (AR), α-glucosidase, and α-amylase enzymes. Read More

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December 2018
2 Reads

Toward stimulating apoptosis in human lung adenocarcinoma cells by novel nano-carmofur compound treatment.

Anticancer Drugs 2018 Nov 19. Epub 2018 Nov 19.

Department of Biology, Faculty of Science, Anadolu University, Eskişehir, Turkey.

Lung cancer is one of the common and most fatal diseases worldwide. It has a high incidence in both men and women, in Turkey. Current antineoplastic drugs are reported to have limitations such as narrow therapeutic index and selectivity, toxicity, and antiproliferative effects on cancer cells. Read More

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November 2018
1 Read

Heavy-metal concentrations in feathers of cinereous vulture (Aegypius monachus L.) as an endangered species in Turkey.

Environ Sci Pollut Res Int 2018 Nov 10. Epub 2018 Nov 10.

Porsuk Vocational School, Eskişehir Technical Universtiy, Eskişehir, Turkey.

The aim of this study is to find out the certain heavy-metal levels in the feathers of cinereous vulture (Aegypius monachus L.), which is a threatened species. The feathers of the cinereous vultures were collected from the breeding areas in Sündiken and Türkmenbaba Mountains. Read More

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November 2018
3 Reads

Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms.

Molecules 2018 Nov 5;23(11). Epub 2018 Nov 5.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.

Novel benzazole derivative compounds ⁻ were obtained by the reaction of corresponding 2-(benzazol-2-ylthio)acetohydrazide and appropriate 4-substituted benzaldehydes. The chemical structures of the synthesized compounds were elucidated by FT-IR, ¹H-NMR, C-NMR and LCMS spectroscopic methods. Antidepressant-like effects of the compounds were evaluated by tail suspension test (TST) and modified forced swimming tests (MFST). Read More

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November 2018
3 Reads

Cytotoxicity of 11 naturally occurring phenolics and terpenoids from Kenyan flora towards human carcinoma cells.

J Ayurveda Integr Med 2018 Oct 30. Epub 2018 Oct 30.

Department of Biology, Science Faculty, Anadolu University, Eskişehir, Turkey.

Background: Cancer constitutes a major hurdle worldwide and its treatment mainly relies on chemotherapy.

Objectives: The present study was designed to evaluate the cytotoxicity of 11 naturally occurring compounds including six phenolics amongst them were 4 chalcones and 2 flavanones as well as 5 terpenoids (3 clerodane and 2 trachylobane diterpenoids) against 6 human carcinoma cell lines and normal CRL2120 fibroblasts.

Materials And Methods: The neutral red uptake (NR) assay was used to evaluate the cytotoxicity of the compounds, whilst caspase-Glo assay was used to detect caspase activation. Read More

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October 2018
1 Read

The association of various social capital indicators and physical activity participation among Turkish adolescents.

J Sport Health Sci 2018 Jan 5;7(1):27-33. Epub 2017 Dec 5.

Department of Physical Education and Sports Teaching, Hacettepe University, Ankara 06800, Turkey.

Background: Physical activity participation (PAP) has been proven to improve health and promote optimal growth among adolescents. However, most adolescents do not meet the current physical activity (PA) recommendations in Turkey. The role of the social environment and social factors on PAP is being increasingly recognized. Read More

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January 2018
6 Reads

Brentuximab vedotin for recurrent Hodgkin lymphoma after allogeneic hematopoietic stem cell transplantation: A report from the EBMT Lymphoma Working Party.

Cancer 2018 Oct 23. Epub 2018 Oct 23.

Department of Haematology, Catala Oncology Institute, Barcelona, Spain.

Background: The treatment of patients with Hodgkin lymphoma (HL) who develop disease progression after undergoing allogeneic stem cell transplantation (allo-SCT) remains challenging.

Methods: The authors assessed outcomes in 184 adult patients with HL who developed disease recurrence or progression after a matched related or unrelated allo-SCT at European Society for Blood and Marrow Transplantation-participating centers between 2010 and 2014.

Results: Eighty patients who received brentuximab vedotin (BV) salvage therapy were compared with 104 patients who did not. Read More

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October 2018
7 Reads
4.890 Impact Factor

Thiazole-substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors.

Drug Dev Res 2018 Oct 21. Epub 2018 Oct 21.

Department of Pharmaceutical Chemistry, Istanbul Medipol University, School of Pharmacy, Istanbul, Turkey.

Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE). Studies on Alzheimer's disease (AD) in the mid-20th century proved that cognitive dysfunctions are associated with cholinergic neurotransmission. Drugs, such as tacrine, rivastigmine, donepezil, and galantamine are known as acetylcholinesterase inhibitors. Read More

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October 2018
3 Reads

Preference and Perception of Enhanced Images During Endonasal Endoscopic Surgery.

J Craniofac Surg 2018 Nov;29(8):2296-2298

Department of Otorhinolaryngology, Ankara University Medical School, Ankara, Turkey.

Image enhancement is used widely in endoscopic sinonasal surgery. It is yet to be established whether image enhancement has advantages over white-light endoscopy. The authors aimed to evaluate the preferences and subjective visual perception of image enhancement in diagnostic images acquired at the beginning of endonasal endoscopic surgeries. Read More

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November 2018
7 Reads

Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma.

Can J Gastroenterol Hepatol 2018 19;2018:4040787. Epub 2018 Sep 19.

Department of Molecular Biology and Genetics, Gebze Technical University, Kocaeli, 41400, Turkey.

Background And Aims: Hepatocellular carcinoma is an aggressive malignancy of the liver and is ranked as the sixth most common cancer worldwide. There is still room for novel markers to improve the diagnosis and monitoring of HCC. Our observations in cancer databases that is upregulated in HCC led us to investigate the expression profile of Plexin C1 mRNA and protein in HCC cell lines and tissues. Read More

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September 2018

The Natural Course of Myxopapillary Ependymoma : An Unusual Case Report and Review of The Literature.

World Neurosurg 2018 Oct 12. Epub 2018 Oct 12.

Craniospinal Surgery Center , Ankara, Turkey.

Spinal cord ependymomas are the most frequent primary intramedullary tumours of the cord in middle age (40-60 years of age). Myixopapillary ependymomas are low incidence tumours and occur in the cauda equina and conus medullaris. They are typically described as fleshly, sausage-shaped, vascular lesions. Read More

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October 2018
6 Reads

Bilateral Vestibulopathy Due to Severe Cochlear Otosclerosis: A Well-Known Condition Without Any Favorable Solution.

Authors:
Sertaç Yetişer

Turk Arch Otorhinolaryngol 2018 Sep 1;56(3):174-176. Epub 2018 Sep 1.

Department of Otorhinolaryngology, Anadolu Medical Center, Kocaeli, Turkey.

Bilateral vestibulopathy is a rare condition. It is one of the most difficult balance problems to treat because nearly all patients experience long-term unsteadiness. In this report, a 39-year-old woman gradually developing chronic dizziness and instability due to bilateral vestibulopathy as a result of progressive severe cochlear otosclerosis was presented with review of the literature. Read More

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September 2018

Evidence for cardiotoxicity associated with sertraline in rats.

Toxicol Res (Camb) 2018 Sep 6;7(5):817-825. Epub 2018 Apr 6.

Anadolu University , Faculty of Pharmacy , Department of Pharmaceutical Toxicology , 26470 Eskisehir , Turkey . Email:

Sertraline is an antidepressant that is frequently prescribed to treat depression, obsessive-compulsive disorder, panic disorder, and anxiety. This drug had a safe cardiotoxicity profile, until the reporting of cases of sertraline-associated cardiotoxicities in the early 2000s. Since then, there have been conflicting results on the cardiotoxicity of this drug. Read More

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September 2018
3 Reads

Identification and characterization of lactic acid bacteria isolated from traditional cone yoghurt.

Food Sci Biotechnol 2017 19;26(6):1625-1632. Epub 2017 Dec 19.

5Department of Nutrition and Dietetics, School of Health Sciences, Gelisim University, Istanbul Gelisim University, Istanbul, Turkey.

Cone yoghurt is a yoghurt variety produced by adding only pine cones to milk without culture in a limited area of Turkey. The present study was conducted to identify and characterize lactic flora in traditional cone yoghurt. Morphological, cultural, physiological, biochemical, and genotypic characteristics were employed to identify lactic acid bacteria isolates from cones and cone yoghurts. Read More

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December 2017

Desertiactinospora gelatinilytica gen. nov., sp. nov., a new member of the family Streptosporangiaceae isolated from the Karakum Desert.

Antonie Van Leeuwenhoek 2018 Sep 25. Epub 2018 Sep 25.

Department of Molecular Biology and Genetics, Faculty of Science and Arts, Ondokuz Mayis University, 55139, Samsun, Turkey.

A novel, Gram-positive, spore-forming actinomycete, designated strain 7K107, was isolated from a soil sample collected from the Karakum Desert, Turkmenistan. Strain 7K107 forms extensively branched substrate mycelia and aerial mycelia which differentiate into short chains of spores. The novel strain contains meso-diaminopimelic acid as the diagnostic wall amino acid and glucose, galactose, madurose and ribose as whole cell sugars. Read More

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September 2018
5 Reads

The effect of hospital clown nurse on children's compliance to burn dressing change.

Burns 2018 Sep 21. Epub 2018 Sep 21.

PhD Student, Sakarya University, Institute of Health Sciences, Department of Nursing, Sakarya, Turkey. Electronic address:

Background And Aim: Pediatric burn injury is a traumatic experience which affects the child both physically and psychologically. Following the burn injury, repetitive dressing changes are one of the main problems, and to manage the level of distress caused this procedure, various distraction strategies are being used. However, the effect of hospital clown during burn dressing change among children has not been studied before. Read More

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September 2018
2 Reads

The knowledge and perceptions of the first year medical students of an International University on family planning and emergency contraception in Nicosia (TRNC).

BMC Womens Health 2018 Sep 15;18(1):149. Epub 2018 Sep 15.

Near East University Faculty of Medicine Department of Public Health, Nicosia, Turkish Republic of Northern Cyprus.

Background: Informing the individuals on family planning including emergency contraception is a significant step for preventing unintended pregnancies. Although there is a number of studies on family planning and emergency contraception globally and in Turkey, no such data are available in the Turkish Republic of Northern Cyprus. The objective of this study was to evaluate the knowledge and perceptions on family planning and emergency contraception of the first year students of an international medical school in Nicosia, Northern Cyprus and to increase awareness for developing new policies on the issue. Read More

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September 2018

Kras-mutation influences outcomes for palliative primary tumor resection in advanced colorectal cancer-a Turkish Oncology Group study.

Surg Oncol 2018 Sep 30;27(3):485-489. Epub 2018 May 30.

Department of Medical Oncology, NecmettinErbakan University, Meram Faculty of Medicine, Konya, Turkey. Electronic address:

Purpose: We aimed to investigate the prognostic effect of primary tumor resection (PTR) prior to bevacizumab-based treatments in unresectable metastatic colorectal cancer (mCRC).

Methods: We retrospectively collected 341 mCRC cases with unresectable metastases at diagnosis. PTR was performed in 210 cases (the surgery group) and the other patients (n = 131) were followed without PTR (the no-surgery group). Read More

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September 2018
2 Reads

Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents.

Drug Chem Toxicol 2018 Sep 12:1-8. Epub 2018 Sep 12.

b Faculty of Science, Department of Biology , Anadolu University , Eskisehir , Turkey.

Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. A series of mononuclear gold (III) and platinum (II) complexes based on boronated phenylalanine (BPA) were designed and synthesized using 4,4'-dimethyl-2,2'-dipyridyl (L1) or 1,10-phenanthroline-5,6-dion (L2) ligands to obtain promising anticancer drug candidates. Read More

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September 2018
2 Reads

Mosquito and tick repellency of two essential oils from Saudi Arabia.

Saudi Pharm J 2018 Sep 27;26(6):860-864. Epub 2018 Mar 27.

Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.

The essential oils (EOs) of (Am) and (As) (Asteraceae) were extracted from the aerial parts of the plants by hydrodistillation, and their chemical compositions were analyzed using GC-FID and GC-MS. Fifty-six components representing 85.5% of the oil composition of were identified, and the major components were -pinene (17. Read More

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September 2018
7 Reads

Determination of real-world emission factors of trace metals, EC, OC, BTEX, and semivolatile organic compounds (PAHs, PCBs and PCNs) in a rural tunnel in Bilecik, Turkey.

Sci Total Environ 2018 Dec 4;643:1285-1296. Epub 2018 Jul 4.

Department of Environmental Engineering, Dokuz Eylul University, Tinaztepe Campus, 35160 Buca, İzmir, Turkey.

A field study was performed in a rural tunnel to determine pollutant concentrations, sources and on road vehicle emission factors (EFs) of particulate matter, trace metals, elemental carbon (EC), organic carbon (OC), benzene, toluene, ethyl benzene and xylenes (BTEX), and polycyclic aromatic hydrocarbons (PAHs). Emission factors (EFs) for polychlorinated naphthalenes (PCNs) and polychlorinated biphenyls (PCBs) were also determined. A 12-day extensive sampling campaign during morning and afternoon periods at inlet and exit stations of the tunnel was conducted. Read More

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December 2018
1 Read

c-Myc inhibitor 10074-G5 induces murine and human hematopoietic stem and progenitor cell expansion and HDR modulator Rad51 expression.

Curr Cancer Drug Targets 2018 Sep 4. Epub 2018 Sep 4.

Yeditepe University - Genetics and Bioengineering Department Istanbul. Turkey.

c-Myc plays a major role in the maintenance of glycolytic metabolism and hematopoietic stem cell (HSC) quiescence. Targeting modulators of HSC quiescence and metabolism could lead to HSC cell cycle entry with concomitant expansion. Here we show that c-Myc inhibitor 10074-G5 treatment leads to 2-fold increase in murine LSKCD34low HSC compartment post 7 days. Read More

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September 2018
3.522 Impact Factor

Selective Recognition of Myoglobin in Biological Samples Using Molecularly Imprinted Polymer-Based Affinity Traps.

Authors:
Rüstem Keçili

Int J Anal Chem 2018 8;2018:4359892. Epub 2018 Aug 8.

Anadolu University, Yunus Emre Vocational School of Health Services, Department of Medical Services and Techniques, 26470 Eskisehir, Turkey.

The current work demonstrates the design, characterization, and preparation of molecularly imprinted microspheres for the selective detection of myoglobin in serum samples. The suspension polymerization approach was applied for the preparation of myoglobin imprinted microspheres. For this purpose, N-methacryloylamino folic acid-Nd (MAFol- Nd) was chosen as the complex functional monomer. Read More

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Purification and Biochemical Characterization of Phytase Enzyme from Lactobacillus coryniformis (MH121153).

Mol Biotechnol 2018 Nov;60(11):783-790

Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.

Phytase (myo-inositol hexaphosphate phosphohydrolase) belongs to phosphatases. It catalyzes the hydrolysis of phytate to less-phosphorylated inorganic phosphates and phytate. Phytase is used primarily for the feeding of simple hermit animals in order to increase the usability of amino acids, minerals, phosphorus and energy. Read More

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November 2018

Structure of corona radiata and tapetum fibers in ventricular surgery.

J Clin Neurosci 2018 Nov 27;57:143-148. Epub 2018 Aug 27.

Department of Neurosurgery, Ankara University, School of Medicine, Ibni Sina Hospital, Ankara, Turkey.

In this study the three-dimensional anatomy of the corona radiata and tapetum via the fiber dissection and diffusion tensor imaging of the brain for ventricular surgery was demonstrated. Ten formalin-fixed cerebral hemispheres were dissected for corona radiata and tapetum via Klingler's fiber dissection method under an operating microscope. The corona radiata and tapetum were dissected through lateral and medial surfaces of the cerebral hemisphere, respectively. Read More

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November 2018
3 Reads

Anti-breast cancer and anti-angiogenic potential of a lichen-derived small-molecule: barbatolic acid.

Authors:
Mehmet Varol

Cytotechnology 2018 Dec 28;70(6):1565-1573. Epub 2018 Aug 28.

Department of Biology, Faculty of Science, Yunusemre Campus, Anadolu University, 26470, Eskisehir, Turkey.

Natural products have been used for centuries as the most potent remedies to cure many diseases including cancer diseases. Angiogenesis is defined as the formation of new capillaries from existing vessels and plays a key role in the tumorigenesis process. Barbatolic acid is a little known lichen-derived small-molecule. Read More

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December 2018
1 Read

Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress.

Oxid Med Cell Longev 2018 29;2018:7196142. Epub 2018 Jul 29.

Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Anadolu University, Eskisehir, Turkey.

Depression and anxiety are recognized as public health problems. Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males. Trazodone is one of the most frequently prescribed drugs in the treatment of depression and anxiety. Read More

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Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress.

Molecules 2018 Aug 27;23(9). Epub 2018 Aug 27.

Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.

Parkinson's disease (PD) is a chronic, progressive, and age-related neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons caused by the accumulation of free radicals and oxidative stress. Based on the neuroprotective properties of 2-pyrazoline derivatives, in the current work, 1-(phenyl/4-substituted phenyl)-3-(2-furanyl/thienyl)-5-aryl-2-pyrazolines (⁻, ⁻) were synthesized via the cyclization of the chalcones (, ) with suitable phenylhydrazine hydrochloride derivatives. All these compounds were investigated for their neuroprotective effects using an in vitro 6-hydroxydopamine (6-OHDA)-induced neurotoxicity model of PD in the rat pheochromocytoma (PC-12) Adh cell line. Read More

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August 2018
1 Read

Knowledge, awareness, and attitude towards infection prevention and management among surgeons: identifying the surgeon champion.

World J Emerg Surg 2018 17;13:37. Epub 2018 Aug 17.

Department of Emergency Surgery, Maggiore Hospital, Parma, Italy.

Despite evidence supporting the effectiveness of best practices of infection prevention and management, many surgeons worldwide fail to implement them. Evidence-based practices tend to be underused in routine practice. Surgeons with knowledge in surgical infections should provide feedback to prescribers and integrate best practices among surgeons and implement changes within their team. Read More

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August 2018
25 Reads
1.060 Impact Factor

How visual stimulus effects the time perception? The evidence from time perception of emotional videos.

Cogn Neurodyn 2018 Aug 9;12(4):357-363. Epub 2018 Feb 9.

1Department of Physiology, Istanbul Faculty of Medicine, İstanbul University, Çapa, 34353 Istanbul, Turkey.

Time perception is defined as a subjective judgment on the elapsed time of an event. It can change according to both external and internal factors. There are two main paradigms of time perception; retrospective time perception (RTP) and prospective time perception (PTP). Read More

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August 2018
1 Read

The Effect of Agomelatine Treatment on Diabetes-Induced Cognitive Impairments in Rats: Concomitant Alterations in the Hippocampal Neuron Numbers.

Int J Mol Sci 2018 Aug 20;19(8). Epub 2018 Aug 20.

Department of Anatomy, Faculty of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, Turkey.

Researches that are related to the central nervous system complications of diabetes have indicated higher incidence of cognitive disorders in patients. Since the variety of nootropic drugs used in clinics is limited and none of them consistently improves the outcomes, new and effective drug alternatives are needed for the treatment of diabetes-induced cognitive disorders. Based on the nootropic potential of agomelatine, the promising efficacy of this drug on cognitive impairments of diabetic rats was investigated in the current study. Read More

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August 2018
5 Reads

Antihyperalgesic Activity of Atomoxetine on Diabetes-Induced Neuropathic Pain: Contribution of Noradrenergic and Dopaminergic Systems.

Molecules 2018 Aug 19;23(8). Epub 2018 Aug 19.

Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

Atomoxetine is a selective noradrenaline reuptake inhibitor drug. Based on the knowledge that agents increasing monoamine levels in the central nervous system have therapeutic potential for neuropathic pain, it is planned to investigate the possible efficacy of atomoxetine on diabetes-induced hyperalgesia, in this study. Randall-Selitto (mechanical noxious stimuli) and Hargreaves (thermal noxious stimuli) tests were used to evaluate nociceptive perception of rats. Read More

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The anti-angiogenic potential of (±) gossypol in comparison to suramin.

Cytotechnology 2018 Dec 19;70(6):1537-1550. Epub 2018 Aug 19.

Department of Biology, Faculty of Science, Ege University, Izmir, Turkey.

Cotton, a staple fiber that grows around the seeds of the cotton plants (Gossypium), is produced throughout the world, and its by products, such as cotton fibers, cotton-seed oil, and cottonseed proteins, have a variety of applications. Cotton-seed contains gossypol, a natural phenol compound. (±)-Gossypol is a yellowish polyphenol that is derived from different parts of the cotton plant and contains potent anticancer properties. Read More

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December 2018
9 Reads

Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease.

Molecules 2018 Aug 14;23(8). Epub 2018 Aug 14.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the weakening of the cholinergic system in the brain. Cholinesterase (ChE) inhibitors are recognized as one of the choices in the treatment of AD. Read More

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August 2018
5 Reads

Application of cellulose 3,5-dichlorophenylcarbamate covalently immobilized on superficially porous silica for the separation of enantiomers in high-performance liquid chromatography.

J Chromatogr A 2018 Oct 4;1571:132-139. Epub 2018 Aug 4.

Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Chavchavadze Ave 3, 0179 Tbilisi, Georgia. Electronic address:

Our earlier studies have demonstrated the applicability of polysaccharide-based chiral selectors in combination with superficially porous (or core-shell) silica (SPS) particles for the preparation of highly efficient chiral stationary phases (CSP). In earlier studies, CSPs were prepared by coating (adsorption) of the chiral selector onto the surface of silica. In this study we report for the first time the CSP obtained by covalent immobilization of a chiral selector onto the surface of SPS particles. Read More

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October 2018
8 Reads

Phytochemical analysis and evaluation of the cytotoxic, antimicrobial and antioxidant activities of essential oils from three Plectranthus species grown in Saudi Arabia.

BMC Complement Altern Med 2018 Aug 10;18(1):237. Epub 2018 Aug 10.

Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.

Background: Cancers and microbial infections are still a major health problem, therefore research on new anticancer and antimicrobial agents ought to be continued. Natural products including essential oils from medicinal plants continue to be an important resource to manage various diseases. Thus, the particular objectives of this study are to investigate the chemical composition, cytotoxic, antimicrobial and antioxidant activities of three Plectranthus species namely P. Read More

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August 2018
8 Reads
2.020 Impact Factor

Separation of terbutaline enantiomers in capillary electrophoresis with cyclodextrin-type chiral selectors and investigation of structure of selector-selectand complexes.

J Chromatogr A 2018 Oct 4;1571:231-239. Epub 2018 Aug 4.

Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Chavchavadze Ave 3, 0179 Tbilisi, Georgia. Electronic address:

The affinity pattern of terbutaline enantiomers towards various cyclodextrins was studied using capillary electrophoresis. The affinity pattern of terbutaline enantiomers was the same towards all studied cyclodextrins except heptakis(2-O-methyl-3,6-di-O-sulfo)-β-CD. Nuclear magnetic resonance spectroscopy was used for understanding of fine structural mechanisms of interactions of β-cyclodextrin and its two sulfated derivatives with the enantiomers of terbutaline. Read More

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October 2018
4.169 Impact Factor

Design and evaluation of biological activities of 1,3-oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties.

Arch Pharm (Weinheim) 2018 Sep 5;351(9):e1800057. Epub 2018 Aug 5.

Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Marmara University, İstanbul, Turkey.

1,3-Oxazolidine-2-one is an important heterocyclic ring participating in the chemical structure of many drugs. In this research, 22 new amide/sulfonamide/thiourea derivatives (1-22) were obtained by the reaction of (S)-4-(4-aminobenzyl)-2(1H)-1,3-oxazolidinone with 4-substituted benzoyl chlorides, 4-substituted benzene sulfonyl chlorides, and 4-substituted phenyl isothiocyanates. The structures of all synthesized compounds were clarified by FT-IR, NMR, and mass spectroscopic and elemental analysis techniques. Read More

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September 2018
2 Reads

Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia.

Int J Biol Macromol 2018 Nov 2;119:857-863. Epub 2018 Aug 2.

Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey.

Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol pathway. α-Glycosidase and α-amylase are important enzymes in glucose metabolism. Read More

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November 2018
7 Reads
2.860 Impact Factor

Synthesis, characterization and antibacterial activity of silver-doped TiO nanotubes.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 25;205:503-507. Epub 2018 Jul 25.

Anadolu University, Science Faculty, Department of Biology, 26470 Eskişehir, Turkey.

One-dimensional titanium dioxide (TiO) nanotubes (TNTs) doped with silver (Ag) (% 5) were synthesized via two-step hydrothermal method. These nanotubes were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The impact of Ag-doped TiO nanotubes as antibacterial agents against three strains of Gram positive Staphylococcus aureus and a strain of Gram negative Escherichia coli was also investigated. Read More

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December 2018

Recent Progress of Imprinted Nanomaterials in Analytical Chemistry.

Int J Anal Chem 2018 2;2018:8503853. Epub 2018 Jul 2.

Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, N J 07102, USA.

Molecularly imprinted polymers (MIPs) are a type of tailor-made materials that have ability to selectively recognize the target compound/s. MIPs have gained significant research interest in solid-phase extraction, catalysis, and sensor applications due to their unique properties such as low cost, robustness, and high selectivity. In addition, MIPs can be prepared as composite nanomaterials using nanoparticles, multiwalled carbon nanotubes (MWCNTs), nanorods, quantum dots (QDs), graphene, and clays. Read More

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July 2018
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An in vitro investigation of genotoxic effects of dexketoprofen trometamol on healthy human lymphocytes.

Drug Chem Toxicol 2018 Jul 27:1-8. Epub 2018 Jul 27.

b Faculty of Sciences, Department of Biology , Anadolu University , Eskisehir , Turkey.

Non-steroidal anti-inflammatory drugs are drugs with analgesic, antipyretic, and anti-inflammatory effects. This study uses in vitro methods to investigate the potential and unknown genotoxic effects of dexketoprofen trometamol, an active substance in painkillers, on healthy human lymphocytes. In this study, a cytokinesis-block micronucleus cytome assay is used to investigate potential clastogenic, aneugenic activity and to identify chromosome breakages caused by the active drug substance dexketoprofen trometamol; a comet assay is performed to identify the genotoxic damage resulting from DNA single-strand breaks; a real-time reverse transcription polymerase chain reaction panel system is used to evaluate the potential negative effects on the expression of the genes responsible for DNA damage assessment. Read More

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July 2018
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Anti-lung Cancer and Anti-angiogenic Activities of New Designed Boronated Phenylalanine Metal Complexes.

Curr Drug Deliv 2018 ;15(10):1417-1425

Department of Biology, Faculty of Science, Anadolu University, Yunusemre Campus, 26470, Eskisehir, Turkey.

Background: Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects.

Objective: A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylalanine (BPA) was designed and synthesized, for the first time, by using 2, 2'-dipyridyl (L1) and 4, 4'-diaminobibenzyl (L2) ligands. Characterization of the synthesized complexes was achieved by using 1H-NMR, IR, MS and elemental analyses. Read More

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January 2018
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Effects of hexagonal boron nitride nanoparticles on antimicrobial and antibiofilm activities, cell viability.

Mater Sci Eng C Mater Biol Appl 2018 Oct 7;91:115-124. Epub 2018 May 7.

Department of Materials Science and Engineering, Anadolu University, Eskişehir 26555, Turkey. Electronic address:

The objective of this work was to investigate the antimicrobial and antibiofilm activities of hBN nanoparticles against Streptococcus mutans 3.3, Staphylococcus pasteuri M3, Candida sp. M25 and S. Read More

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October 2018
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Development of Validated and Stability-Indicating LC-DAD and LC-MS/MS Methods for Determination of Avanafil in Pharmaceutical Preparations and Identification of a Novel Degradation Product by LCMS-IT-TOF.

Authors:
Nafiz Öncü Can

Molecules 2018 Jul 19;23(7). Epub 2018 Jul 19.

Department of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.

Avanafil (AVA), one of the most effective drugs prescribed for erectile dysfunction, is a pyrimidine-derivative PDE5 inhibitor. In the current work, new LC methods were developed and validated for quantitative determination of avanafil and qualitative determination of its degradation products. The quantitative determination of avanafil was carried out using liquid chromatography with photodiode array detection (LC-DAD) and liquid chromatography-tandem mass spectrometry LC-MS/MS methods, and fully validated according to the ICH Q2 (R1) guideline, while qualitative determination was performed using a liquid chromatography mass spectrometry-ion trap-time of flight (LCMS-IT-TOF) instrument. Read More

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July 2018
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