3,839 results match your criteria Anadolu Psikiyatri Dergisi-anatolian Journal Of Psychiatry[Journal]


UV disinfection as an adjunctive method in the interventional suite.

Diagn Interv Radiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, Anadolu Medical Center Hospital affiliated with John's Hopkins Hospital, Gebze, Kocaeli, Turkey.

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http://dx.doi.org/10.5152/dir.2020.20250DOI Listing

Early Access Program Results From Turkey and a Literature Review on Daratumumab Monotherapy Among Heavily Pretreated Patients With Relapsed/Refractory Myeloma.

Clin Lymphoma Myeloma Leuk 2020 Mar 7. Epub 2020 Mar 7.

Department of Hematology, Ankara University Faculty of Medicine, Ankara, Turkey.

Background: In countries where frontline drug approval is limited to first-generation proteasome inhibitors or immunomodulatory drugs, relapses have been both more frequent and less durable. We investigated real world data on the efficacy and safety of daratumumab monotherapy among patients with relapsed refractory multiple myeloma (RRMM) from Turkey using a prospective early access program.

Patients And Methods: A total of 42 patients with RRMM after a minimum of 3 previous lines of proteasome inhibitor/immunomodulatory drug-based treatments were included from 25 centers across Turkey. Read More

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http://dx.doi.org/10.1016/j.clml.2020.02.017DOI Listing

Implementation of World Health Organization Guidelines in the Prevention of Surgical Site Infection in Low- and Middle-Income Countries-What We Know and Do Not Know.

Surg Infect (Larchmt) 2020 Jun 1. Epub 2020 Jun 1.

S3 Global, Glasgow, United Kingdom.

In low- and middle-income countries (LMICs), infection is the most frequent complication in surgical procedures, and surgical site infections (SSIs) globally are the most frequent health-care-associated infections (HAIs). Preventing SSI is an important target for overall quality improvement and patient safety as well as supporting the infection prevention and control (IPC) global agenda. In 2018, the World Heath Organization (WHO) presented the first Global Guidelines for the Prevention of Surgical Site Infections. Read More

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http://dx.doi.org/10.1089/sur.2020.163DOI Listing

Novel approaches to cancer therapy with ibuprofen loaded Eudragit RS 100 and/or octadecylamine modified PLGA nanoparticles by assessment of their effects on apoptosis.

Drug Dev Ind Pharm 2020 May 31:1-39. Epub 2020 May 31.

Faculty of Pharmacy, Department of Pharmaceutical Technology, Anadolu University, 26470-Eskişehir, Turkey.

The purpose of this study was the design ibuprofen (IBU) loaded unique Eudragit® RS 100 (ERS) and/or octadecylamine modified PLGA nanoparticles (NPs) for cancer treatment. The rational for this approach is to bring a new approach to cancer treatment with modification of IBU loaded PLGA NPs with ERS and/or octadecylamine by means of smaller particle size (PS), cationic surface, biocompatible nature and investigating their selective efficacy on lung cell lines (A549 lung cancer cell and CCD-19Lu normal cell line). IBU encapsulated PLGA based NPs were prepared and characterized for physical and solid-state analyses. Read More

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http://dx.doi.org/10.1080/03639045.2020.1776319DOI Listing

Treatment of Periarticular Fractures of the Knee Using the Less Invasive Stabilization System: A Retrospective Clinical Trial.

Cureus 2020 Apr 22;12(4):e7773. Epub 2020 Apr 22.

Orthopaedics and Traumatology, Bursa Acıbadem Hospital, Bursa, TUR.

Introduction Periarticular fractures of the knee in adults are generally treated with internal fixation. The Less Invasive Stabilization System (LISS) plate, developed by Arbeitsgemeinschaft Osteosynthesefragen (AO)/Association for the Study of Internal Fixation (ASIF) in the late 1990s, allows reduction and biological fixation through smaller incisions without violating periosteal blood supply. It offers several advantages for the treatment of complex periarticular fractures of the knee. Read More

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http://dx.doi.org/10.7759/cureus.7773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243630PMC

Levocetirizine Dihydrochloride-Loaded Chitosan Nanoparticles: Formulation and Evaluation.

Turk J Pharm Sci 2020 Feb 19;17(1):27-35. Epub 2020 Feb 19.

Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eskişehir, Turkey.

Objectives: The aim of the present study was to formulate levocetirizine hydrochloride (LCD)-loaded chitosan nanoparticles at submicron level with high entrapment efficiency and prolonged effect for optimizing the plasma drug concentration enhancing bioavailability.

Materials And Methods: LCD was successfully incorporated into chitosan nanoparticles by spray drying for the purpose of oral application. characteristics were evaluated in detail. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.34392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227860PMC
February 2020

Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells.

Turk J Pharm Sci 2019 Jun 27;16(2):119-131. Epub 2019 Mar 27.

Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eskişehir, Turkey.

Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt.

Materials And Methods: Due to the importance of thiadiazoles for anticancer drug discovery, herein eight 1,3,4-thiadiazole derivatives were investigated for their cytotoxic effects on C6 rat glioma and A549 human lung adenocarcinoma cell lines using the MTT assay. The effects of the most promising anticancer agents on apoptosis, caspase-3 activation, mitochondrial membrane potential, and cell cycle arrest were determined on a BD FACSAria (I) flow cytometer. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2019.2018.96658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227970PMC

Double challenge: cochlear implantation in the only hearing ear with progressive hearing loss following meningitis and vestibular dysfunction after implantation.

J Otol 2020 Jun 14;15(2):74-76. Epub 2019 Nov 14.

Anadolu Medical Center, Dept of Radiology, Kocaeli, 41400, Turkey.

Objective: Vestibular dysfunction associated with cochlear implantation is rare. It is usually seen in patients with otosclerosis due to spread of electrical activity throughout the demineralized bone. A 17-year old female with progressive hearing loss 2 years after meningitis and vestibular dysfunction in the implanted ear is presented in this study. Read More

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http://dx.doi.org/10.1016/j.joto.2019.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231986PMC

Cushing's disease due to a pituitary adenoma as a component of collision tumor: A case report and review of the literature.

J Med Case Rep 2020 May 19;14(1):59. Epub 2020 May 19.

Department of Neurosurgery, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey.

Background: The coexistence of two morphologically different tumors attached to each other creates a very rare type of tumor called a collision tumor. Collision tumors containing pituitary adenoma-sellar meningioma have only been described in four cases to date; we discuss a fifth case harboring a collision tumor comprising a pituitary corticotroph adenoma and a sellar meningioma in the same anatomic position.

Case Presentation: A 34-year-old Caucasian woman presented with menstrual irregularity, severe weakness of the proximal muscles, and 10-15 kg weight gain within a year. Read More

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http://dx.doi.org/10.1186/s13256-020-02382-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236304PMC

Development of a RP-HPLC method for simultaneous determination of reference markers used for in-situ rat intestinal permeability studies.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 7;1147:122150. Epub 2020 May 7.

Department of Medical Services and Techniques, Yunus Emre Vocational School of Health Services, 26470 Eskişehir, Turkey; Department of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

One of the most common techniques for assessing the intestinal absorption characteristics of drugs is single-pass intestinal perfusion (SPIP) method. Metoprolol tartrate (MT, reference standard) and phenol red (PR, zero permeability marker) are the compounds that are normally used in SPIP studies. The aim of this study was to develop a reverse phase high-performance liquid chromatography (RP-HPLC) method combined with UV-detection for the simultaneous determination of MT and PR in the perfusion medium used in SPIP experiments. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122150DOI Listing

Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs.

Bioorg Chem 2020 May 4;100:103897. Epub 2020 May 4.

Department of Chemistry, Faculty of Arts and Sciences, Harran University, Şanlıurfa 63290, Turkey.

Some metabolic enzyme inhibitors can be used in the treatment of many diseases. Therefore, synthesis and determination of alternative inhibitors are essential. In this study, the inhibition effect of newly synthesized compounds on carbonic anhydrase (cytosolic isoforms, hCA I and hCA II), α-glycosidase (α-GLY), and acetylcholinesterase (AChE) were investigated. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103897DOI Listing

Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents.

Acta Pharm 2020 Dec;70(4):499-513

Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University, 26470Eskişehir Turkey.

The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[(5-(substituted amino)-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives and investigation of their anticancer activities were the aims of this work. All the new compounds' structures were elucidated by elemental analyses, IR, 1H NMR, 13C NMR and MS spectral data. Anticancer activity studies of the compounds were evaluated against MCF-7 and A549 tumor cell lines. Read More

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http://dx.doi.org/10.2478/acph-2020-0034DOI Listing
December 2020

Development of Small Molecule MEIS Inhibitors that modulate HSC activity.

Sci Rep 2020 May 14;10(1):7994. Epub 2020 May 14.

Regenerative Biology Research Laboratory, Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.

Meis1, which belongs to TALE-type class of homeobox gene family, appeared as one of the key regulators of hematopoietic stem cell (HSC) self-renewal and a potential therapeutical target. However, small molecule inhibitors of MEIS1 remained unknown. This led us to develop inhibitors of MEIS1 that could modulate HSC activity. Read More

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http://dx.doi.org/10.1038/s41598-020-64888-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224207PMC

Evaluation of the Reasons for the Cancellation of Elective Procedures at Level 3 University Hospital on the Day of Surgery.

J Perianesth Nurs 2020 May 10. Epub 2020 May 10.

Department of Anaesthesiology and Reanimation, Fırat University School of Medicine, Elazığ, Turkey.

Purpose: Unexpected cancellations of planned elective procedures are a global problem for hospitals, causing a waste of hospital resources and manpower, and reduces the efficiency of hospitals. In this study, we tried to identify the causes of cancellations of elective procedures, and to examine the relationship between the causes.

Design: A retrospective, descriptive single-center study. Read More

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http://dx.doi.org/10.1016/j.jopan.2019.12.008DOI Listing

Bone marrow versus mobilized peripheral blood stem cell graft in T-cell-replete haploidentical transplantation in acute lymphoblastic leukemia.

Leukemia 2020 May 11. Epub 2020 May 11.

EBMT ALWP Office, Saint Antoine Hospital, Paris, France.

The ideal stem cell graft source remains unknown in haploidentical haematopietic cell transplantation (haplo-HCT) with posttransplantation cyclophosphamide (PTCy). This study compared outcomes of bone marrow (BM) versus peripheral blood (PB) stem cell graft for haplo-HCT in acute lymphoblastic leukemia (ALL). A total of 314 patients with ALL (BM-157; PB-157) were included in this study. Read More

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http://dx.doi.org/10.1038/s41375-020-0850-9DOI Listing

RuBisCO nano enzyme for mimicking CO conversion system in plants.

Biotechnol Appl Biochem 2020 May 10. Epub 2020 May 10.

Department of Chemistry, Faculty of Sciences, Eskişehir Technical University, Yunus Emre Campus, 26470, Tepebaşı, Eskişehir, Turkey.

In this study, carbon dioxide (CO ) capture and conversion systems based on the combination of biomimetic systems with nano enzymes have been developed. The effectiveness of the developed system has been investigated towards CO conversion. For this aim, nano ribulose bisphosphate carboxylase/oxygenase (RuBisCO) enzyme that plays role in the Calvin cycle in photosynthesis has been synthesized in 93 nm size according to AmiNoAcid (monomer) Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) method. Read More

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http://dx.doi.org/10.1002/bab.1937DOI Listing

Synthesis, characterization, and in vivo pharmacological evaluation of novel mannich bases derived from 1,2,4-triazole containing a naproxen moiety.

Bioorg Chem 2020 May 1;100:103892. Epub 2020 May 1.

Hacettepe University, Faculty of Pharmacy, Dept of Pharmaceutical Chemistry, 06100 Ankara, Turkey. Electronic address:

A new series of 1,2,4-triazole-5-thione Mannich derivatives containing a naproxen moiety (1a-o) was designed and synthesized to create naproxen analogs, with the aim of developing novel anti-inflammatory/analgesic agents with improved safety profiles. Target compounds were synthesized using classical Mannich reaction (i.e. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103892DOI Listing

Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate.

Eur J Med Chem 2020 May 4;198:112392. Epub 2020 May 4.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

In this study, novel dithiocarbamate-sulfonamide derivatives (3a-3k) were synthesized to investigate their inhibitory activity on purified human carbonic anhydrase (hCA) I and II. The IC and K values of the compounds were calculated to compare their inhibition profiles on hCA I and II isoenzymes. Acetazolamide was used as the standard inhibitor in the enzyme inhibition assay. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112392DOI Listing

2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting.

World J Emerg Surg 2020 May 7;15(1):32. Epub 2020 May 7.

Department of Emergency Surgery, Parma Maggiore Hospital, Parma, Italy.

Acute colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in the acute setting. An international multidisciplinary panel of experts from the World Society of Emergency Surgery (WSES) updated its guidelines for management of acute left-sided colonic diverticulitis (ALCD) according to the most recent available literature. The update includes recent changes introduced in the management of ALCD. Read More

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http://dx.doi.org/10.1186/s13017-020-00313-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206757PMC
May 2020
1.062 Impact Factor

Inferior Turbinate Surgery with a Piezo Device in Rhinoplasty.

Facial Plast Surg Aesthet Med 2020 May 7. Epub 2020 May 7.

Rinocenter, Istanbul, Turkey.

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http://dx.doi.org/10.1089/fpsam.2020.0015DOI Listing

Opuntia ficus indica Fruits Ameliorate Cisplatin-Induced Nephrotoxicity in Mice.

Biol Pharm Bull 2020 ;43(5):831-838

Cerrahpaşa University, School of Medicine, Department of Histology and Embryology.

This study aims to determine the potential renal protective effects of Opuntia ficus-indica (L.) Miller (OFI) fruits against cisplatin-induced nephrotoxicity in mice. The antioxidant activity of OFI methanol extract was calculated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) free radical scavenging assays. Read More

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http://dx.doi.org/10.1248/bpb.b19-01044DOI Listing
January 2020

Anticancer and antimetastatic activity of Hypomyces chrysospermus, a cosmopolitan parasite in different human cancer cells.

Mol Biol Rep 2020 May 6;47(5):3765-3778. Epub 2020 May 6.

Faculty of Science and Letters, Department of Biology, Eskisehir Osmangazi University, 26480, Eskisehir, Turkey.

The importance of microbial natural compounds in drug research is increasing every year and they are used to prevent or treat a variety of diseases. Hypomyces chrysospermus is a cosmopolitan parasite of many Boletaceae members. Since not much work has been conducted to date, this study is undertaken to explore the anticancer effect, including the antiproliferative and antimetastatic activity of Hypomyces chrysospermus. Read More

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http://dx.doi.org/10.1007/s11033-020-05468-6DOI Listing

Chemical Characterization and Biological Activity of the Mastic Gum Essential Oils of Var. from Turkey.

Molecules 2020 May 2;25(9). Epub 2020 May 2.

Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.

The essential oils (EOs) were isolated by hydrodistillation from wild and cultivated L. var. mastic gum tree (Anacardiaceae) from two natural habitats, namely from Cesme-Uzunkoy (1) and Mordogan (2), and one cultivated source, Cesme-Germiyan (3), in Izmir, Turkey. Read More

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http://dx.doi.org/10.3390/molecules25092136DOI Listing

Post-transplant cyclophosphamide versus anti-thymocyte globulin for graft-versus-host disease prevention in haploidentical transplantation for adult acute lymphoblastic leukemia.

Haematologica 2020 Apr 30. Epub 2020 Apr 30.

Saint Antoine Hospital and Université Pierre et Marie Curie, Paris, France.

Graft-versus-host disease (GVHD) prophylaxis for unmanipulated haploidentical hematopoietic cell transplantation (haplo-HCT) include post-transplant cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG). Utilizing EBMT registry, we compared ATG versus PTCy based GVHD prophylaxis in adult acute lymphoblastic leukemia (ALL) patients undergoing haplo-HCT. Included were 434 patients; ATG (n=98) and PTCy (n=336). Read More

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http://dx.doi.org/10.3324/haematol.2020.247296DOI Listing

Moxifloxacin Hydrochloride-Loaded Eudragit® RL 100 and Kollidon® SR Based Nanoparticles: Formulation, In vitro Characterization and Cytotoxicity.

Comb Chem High Throughput Screen 2020 Apr 27. Epub 2020 Apr 27.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Anadolu University, Eskişehir. Turkey.

Background: Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there's a need for designing efficient novel drug delivery systems that may enhance of precorneal retention time and corneal permeability.

Aim And Objective: The current research focuses on developing nanosized and non-toxic Eudragit® RL 100 and Kollidon® SR nanoparticles loaded with moxifloxacin hydrochloride (MOX) for its prolonged release to be promising for effective ocular delivery.

Methods: In this study, MOX was incorporation was carried out by spray drying method aiming ocular delivery. Read More

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http://dx.doi.org/10.2174/1386207323666200428091945DOI Listing

The adverse effects of psychotropic drugs as an endocrine disrupting chemicals on the hypothalamic-pituitary regulation in male.

Authors:
Sinem Ilgin

Life Sci 2020 Apr 24;253:117704. Epub 2020 Apr 24.

Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey. Electronic address:

Adverse effects of drugs on male reproductive system can be categorized as pre-testicular, testicular, and post-testicular. Pre-testicular adverse effects disrupt the hypothalamic-pituitary-gonadal (HPG) axis, generally by interfering with endocrine function. It is known that the HPG axis has roles in the maintenance of spermatogenesis and sexual function. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117704DOI Listing

Childhood Emotional Incest Scale (CEIS): Development, validation, cross-validation, and reliability.

J Couns Psychol 2020 Apr 20. Epub 2020 Apr 20.

Department of Guidance and Counseling, Faculty of Education, Anadolu University.

Describing a maladaptive parent-child relationship wherein a parent turns to a child for the satisfaction of emotional and/or relational needs, emotional incest remains an underinvestigated phenomenon. This is partly due to a lack of an empirically based measure of childhood emotional incest, and as a result, a 2-factor, 12-item scale was created based on expert opinion and a preliminary study of 319 university students. Each consisting of 6 items, the factors were called "Surrogate Spouse" and "Unsatisfactory Childhood. Read More

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http://dx.doi.org/10.1037/cou0000439DOI Listing

CD34+ cell dose effects on clinical outcomes after T-cell replete haploidentical allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia using peripheral blood stem cells. A study from the acute leukemia working Party of the European Society for blood and marrow transplantation (EBMT).

Am J Hematol 2020 Apr 17. Epub 2020 Apr 17.

Saint-Antoine Hospital, Paris, France.

Previous observations have reported controversial conclusions regarding cell dose and survival endpoints after allogeneic hematopoietic stem cell transplantation (HSCT). We conducted a retrospective analysis on 414 adult patients (median age 54 years, range, 18-74 years) with acute myeloid leukemia (AML) in first and second complete remission. They received a T-cell replete allogeneic HSCT from haploidentical donors, using peripheral blood stem cells, between 2006-2018. Read More

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http://dx.doi.org/10.1002/ajh.25826DOI Listing

Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors.

Arch Pharm (Weinheim) 2020 Jun 13;353(6):e1900383. Epub 2020 Apr 13.

Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, Turkey.

In this study, 15 novel compounds in a series of sulfonamide-based ketenes (7a-o) were synthesized and characterized using Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry. All compounds were tested for their ability to inhibit the human carbonic anhydrase (hCA) isoforms I and II, and acetylcholinesterase (AChE). The halogen-appended compounds, 7g, 7o, and 7i, exhibited the highest hCA I/II and AChE inhibition, with the K values in the low nanomolar range (K  = 9. Read More

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http://dx.doi.org/10.1002/ardp.201900383DOI Listing

Effect of different molecular weight PLGA on flurbiprofen nanoparticles: formulation, characterization, cytotoxicity, and anti-inflammatory effect by using HET-CAM assay.

Drug Dev Ind Pharm 2020 Apr 23;46(4):682-695. Epub 2020 Apr 23.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Çukurova University, Adana, Turkey.

The effect of polymers used in nanoparticle (NP) production on the formulation properties is one of the few studied issues. Therefore, this study aims to formulate flurbiprofen (FLB) loaded NPs with different molecular weight (M) poly lactic--glycolic acid (PLGA) and investigate the effect of M on NP character. One of the most important objectives is to provide a high anti-inflammatory effect with a low dose and the anti-inflammatory efficacy of the selected optimal formulation is to be determined by hen's egg test on Chorioallantoic Membrane (HET-CAM) analysis that a new, popular and animal experiment alternative method. Read More

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http://dx.doi.org/10.1080/03639045.2020.1755304DOI Listing

Secondary metabolites from Lam. and their bioactivities.

Nat Prod Res 2020 Apr 11:1-5. Epub 2020 Apr 11.

Faculty of Pharmacy, Department of Pharmacognosy, Yeditepe University, İstanbul, Turkey.

Five iridoid glycosides catalpol (), specioside (), ajugol (), ajugoside (), 8--acetylharpagide (), two phenylethanoid glycosides, verbascoside () and glucopyranosyl-(1→G-6)-martynoside (), four flavonoids, luteolin (), luteolin 7--β-glucopyranoside (), luteolin 7--rutinoside (), apigenin 7--rutinoside (), quercetin 3--rutinoside () and β-sitosterol were isolated from the aerial parts of Lam. for the first time. Their structures were elucidated by NMR and MS experiments. Read More

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http://dx.doi.org/10.1080/14786419.2020.1753052DOI Listing

Imaging and clinical correlates with regorafenib in metastatic colorectal cancer.

Cancer Treat Rev 2020 Jun 4;86:102020. Epub 2020 Apr 4.

Institut Jules Bordet, 121 Boulevard de Waterloo, 1000 Brussels, Belgium. Electronic address:

In colorectal cancer (CRC), imaging is important in determining tumor stage, selecting treatment strategies, and in assessing response to therapy. However, some challenges remain with established imaging techniques, such as computed tomography, and with some commonly used response criteria, such as Response Evaluation Criteria in Solid Tumors, which measures change in size of several target lesions instead of change in tumor morphology or metabolic function. In addition, these assessments are not typically conducted until after 8 weeks of treatment, meaning that potential non-responders are often not identified in a timely manner. Read More

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http://dx.doi.org/10.1016/j.ctrv.2020.102020DOI Listing

A nosocomial scabies outbreak originating from immunocompromised transplant patients in Turkey: Upholstery as a possible cause.

Transpl Infect Dis 2020 Apr 10:e13284. Epub 2020 Apr 10.

Department of Clinical Microbiology, Anadolu Medical Center, Gebze, Turkey.

Background: Inpatients with crusted scabies represent an important source of nosocomial transmission with consequent outbreaks among patients and healthcare workers. This study aimed to report the course of an institutional scabies outbreak, which progressed with infestation of immunosuppressed transplant patients, health care workers, and caregivers.

Methods: Patients diagnosed with scabies in a nosocomial outbreak in a 200-bed, tertiary hospital were included. Read More

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http://dx.doi.org/10.1111/tid.13284DOI Listing

Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor.

Molecules 2020 Apr 2;25(7). Epub 2020 Apr 2.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.

In the last step of estrogen biosynthesis, aromatase enzyme catalyzes the conversion of androgens to estrogens. Aromatase inhibition is an important way to control estrogen-related diseases and estrogen levels. In this study, sixteen of benzimidazole-triazolothiadiazine derivatives have been synthesized and studied as potent aromatase inhibitors. Read More

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http://dx.doi.org/10.3390/molecules25071642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180718PMC

Synthesis, characterisation, biological evaluation and studies of sulphonamide Schiff bases.

J Enzyme Inhib Med Chem 2020 Dec;35(1):950-962

NEUROFARBA Department, Sezione di Scienze Farmaceutiche, Universita degli Studi di Firenze, Florence, Italy.

Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, C NMR, H NMR, LC-MS and elemental analysis. Their inhibitory effect on AChE, and carbonic anhydrase I and II enzyme activities was investigated. Read More

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http://dx.doi.org/10.1080/14756366.2020.1746784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170330PMC
December 2020
2.383 Impact Factor

Potential Antioxidant and Enzyme Inhibitory Effects of Nanoliposomal Formulation Prepared from Rech. f. Extract.

Antioxidants (Basel) 2020 Apr 1;9(4). Epub 2020 Apr 1.

Faculty of Pharmacy, Department of Pharmacognosy, Gazi University, 06330 Ankara, Turkey.

Rech. f. is a species that grows only in Hatay, Turkey and is used as a traditional stomachic tea. Read More

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http://dx.doi.org/10.3390/antiox9040293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222214PMC

Identification and comparison of exosomal microRNAs in the milk and colostrum of two different cow breeds.

Authors:
Selçuk Özdemir

Gene 2020 Jun 24;743:144609. Epub 2020 Mar 24.

Atatürk University, Faculty of Veterinary Medicine, Department of Genetics, Erzurum, Turkey. Electronic address:

Bovine milk and colostrum provide essential nutrients and immunologically active factors that are beneficial to a newborn calf. Milk-and-colostrum-derived exosomes are known as the most important for cellular communication. Exosomes also contain non-coding RNA, such as microRNA. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144609DOI Listing

The use of ecological footprint in estimating the Environmental Kuznets Curve hypothesis for BRICST by considering cross-section dependence and heterogeneity.

Sci Total Environ 2020 Jun 19;723:138063. Epub 2020 Mar 19.

Anadolu University Faculty of Tourism Eskişehir-Turkey. Electronic address:

A vast body of literature estimates the impact of economic growth on environmental degradation in the framework of EKC model. Typical empirical studies proxy environmental degradation with CO emissions; however, this indicator does not consider the complex nature of environmental degradation. To fulfill this omission, ecological footprint that tracks the use of multiple categories of productive surface areas is used as proxy for the environment. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138063DOI Listing

Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A new approach to use antiretroviral drug for lung cancer treatment.

Comb Chem High Throughput Screen 2020 Mar 25. Epub 2020 Mar 25.

Anadolu University, Medicinal Plant, Drug and Scientific Research Center (AUBIBAM), 26470 Eskişehir. Turkey.

Aim: To prepare lamivudine (LAM)-loaded-nanoparticles (NPs) that can be used in cancer treatment. To change the antiviral indication of LAM to anticancer.

Background: Development of anticancer drugs is a difficult process. Read More

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http://dx.doi.org/10.2174/1386207323666200325155020DOI Listing

Publication and Citation Analysis of Medical Doctors' Residency Master's Theses Involving Animal Experiments on Rats in Turkey.

Altern Lab Anim 2020 Jan 20;48(1):23-28. Epub 2020 Mar 20.

Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

The number of non-human animals used in research has increased in line with advances in medical technology, although it has previously been shown that these experiments demonstrate poor human utility. This study aimed to determine the effectiveness of animal studies on rats that were performed as part of medical doctors' residency master's theses prepared in Turkey between January 2006 and December 2015. The number of thesis-derived published papers from each year, as well as the subsequent citation rate of these papers, was determined. Read More

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http://dx.doi.org/10.1177/0261192920907226DOI Listing
January 2020

Insecticidal and Biting Deterrent Activities of Essential Oils and Selected Pure Compounds against .

Molecules 2020 Mar 17;25(6). Epub 2020 Mar 17.

National Center for Natural Products Research, The University of Mississippi, Oxford, MS 38677, USA.

In our natural products screening program for mosquitoes, we tested essential oils extracted from different plant parts of L. for their insecticidal and biting deterrent activities against . Biting deterrence of seeds essential oil with biting deterrence index value of 0. Read More

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http://dx.doi.org/10.3390/molecules25061359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144101PMC

Caffeoylquinic Acids, Cytotoxic, Antioxidant, Acetylcholinesterase and Tyrosinase Enzyme Inhibitory Activities of Six Inula Species from Bulgaria.

Chem Biodivers 2020 Apr 18;17(4):e2000051. Epub 2020 Mar 18.

Faculty of Biology, Sofia University, 'St. Kliment Ohridski', 1164, Sofia, Bulgaria.

Chlorogenic (5-CQA), 1,5-, 3,5-, 4,5- and 3,4-dicaffeoylquinic (DCQA) acids were identified and quantified in the methanol extracts of Inula oculus-christi L., I. bifrons L. Read More

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http://dx.doi.org/10.1002/cbdv.202000051DOI Listing

Nasal colonization with methicillin-resistant at admission among high-risk Turkish and international patients.

Authors:
Melda Ozdamar

Acta Microbiol Immunol Hung 2020 Mar 9:1-6. Epub 2020 Mar 9.

Department of Clinical Microbiology, Anadolu Medical Center, Gebze, Kocaeli, Turkey.

Objective: The aim of this study was to detect the frequency of methicillin-resistant (MRSA) colonization at admission in a group of presumably high-risk international or Turkish patients referred to our center for elective operations, some of whom were from countries with an unknown prevalence of MRSA infection or colonization.

Methods: The results of nasal swab screening for MRSA colonization performed using a specific algorithm between 2011 and 2018 in a private medical center were retrospectively reviewed. Presence of MRSA was ascertained using culture and/or real-time polymerase chain reaction (real-time PCR). Read More

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http://dx.doi.org/10.1556/030.2020.01081DOI Listing

Synthesis and docking study of benzimidazole-triazolothiadiazine hybrids as aromatase inhibitors.

Arch Pharm (Weinheim) 2020 May 11;353(5):e2000008. Epub 2020 Mar 11.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.

Aromatase is involved in the biosynthesis of estrogen and thus is a critical target for breast cancer. In this study, to identify new aromatase enzyme inhibitors, seven 3-[4-(5-methyl-1H-benzo[d]imidazol-2-yl)phenyl]-6-(substituted phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives were synthesized. First, a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to determine the inhibitory activity of the synthesized compounds on the MCF-7 cell line. Read More

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http://dx.doi.org/10.1002/ardp.202000008DOI Listing

The effect of R547, a cyclin-dependent kinase inhibitor, on hepatocellular carcinoma cell death.

Turk J Biol 2020 17;44(1):24-33. Epub 2020 Feb 17.

Department of Physiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir Turkey.

Hepatocellular carcinoma (HCC) is the third main cause of cancer-related death. Cyclin-dependent kinases (CDKs) and their cyclin partners regulate the cell cycle. Since inhibition of CDKs gives some guiding ideas for cancer studies, we aimed to determine the possible effects of R547, a cyclin kinase 1-2-4 inhibitor, on proliferation and apoptotic mechanisms of Hep G2 cells (human) and H-4-II-E cells derived from rat HCC. Read More

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http://dx.doi.org/10.3906/biy-1907-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049457PMC
February 2020

Review: The nicotinic modulation of pain.

Pak J Pharm Sci 2020 Jan;33(1):229-239

Anadolu University Faculty of Pharmacy, Department of Pharmacology, Eskisehir Turkey.

Pain is a physiological unpleasant sensation that associated with actual or potential tissue damage and affects the major part of human population. Numerous modulatory system control pain through a complex process. The drugs that regulate the modulators involving in this process are currently available; however, the studies to understand the process and develop new agents are still going on. Read More

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January 2020

Calcium channel blockers: molecular docking and inhibition studies on carbonic anhydrase I and II isoenzymes.

J Biomol Struct Dyn 2020 Mar 9:1-9. Epub 2020 Mar 9.

Faculty of Pharmacy, Department of Biochemistry, Anadolu University, Eskişehir, Turkey.

Carbonic anhydrases (CAs) are potent dehydration of carbonic acid and catalyst of the reversible hydration of carbon dioxide. Here, CA I and CA II was purified from human erythrocytes using the simple chromatographic method and determined the interactions between some calcium channel blockers and the enzymes. Molecular docking studies were performed these compounds. Read More

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http://dx.doi.org/10.1080/07391102.2020.1736631DOI Listing

Diclofenac sodium loaded PLGA nanoparticles for inflammatory diseases with high anti-inflammatory properties at low dose: Formulation, characterization and in vivo HET-CAM analysis.

Microvasc Res 2020 Jul 24;130:103991. Epub 2020 Feb 24.

Anadolu University, Faculty of Pharmacy, Department of Pharmacognosy, 26470 Eskişehir, Turkey.

The development of a new drug active substance is not only time-consuming and expensive, but also a chain of operations that often fails. However, increasing the bioavailability, effectiveness, safety, or targeting the drugs used in clinic by various methods, such as nanoparticles (NPs), may be a more effective way of using them in clinic. In addition, NP formulations are becoming increasingly popular in modern medical treatments. Read More

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http://dx.doi.org/10.1016/j.mvr.2020.103991DOI Listing

The etiology of notalgia paresthetica: a descriptive study of 117 patients.

Ir J Med Sci 2020 Feb 21. Epub 2020 Feb 21.

Department of Public Administration, Faculty of Economics, Anadolu University, Eskişehir, Turkey.

Background: Notalgia paresthetica (NP) is a neuropathic itching condition unilaterally localized in the midscapular area. It is a common but an underdiagnosed disease, and only a few studies investigating NP etiology with a limited number of patients have been reported in the literature.

Objective: We aimed to evaluate the demographic, clinical, histopathological, neurological, and radiological findings of NP patients and investigate correlations between them and symptoms of NP to elucidate the etiology of NP. Read More

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http://dx.doi.org/10.1007/s11845-019-02133-1DOI Listing
February 2020