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Arch Pharm (Weinheim) 2022 May 23:e2200136. Epub 2022 May 23.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.

In an endeavor to identify potent anti-inflammatory agents, new thiosemicarbazones (TSCs) incorporated into a diaryl ether framework (2a-2l) were prepared and screened for their in vitro inhibitory effects on cyclooxygenases (COXs). 4-[4-(Piperidin-1-ylsulfonyl)phenyl]-1-[4-(4-cyanophenoxy)benzylidene]thiosemicarbazide (2c) was the most potent and selective COX-1 inhibitor in this series, with an IC value of 1.89 ± 0. Read More

J Back Musculoskelet Rehabil 2022 May 13. Epub 2022 May 13.

Physiotherapy and Rehabilitation Department, Faculty of Health Sciences, Near East University, Nicosia, Cyprus.

Background: The relationship between the endurance of the lumbar paraspinal muscles and morphological changes needs to be clarified. In this context, the importance can be revealed of increasing the endurance level of the paraspinal muscles in the prevention and treatment of low back diseases.

Objective: The aim of this study was to examine the relationship between the clinical evaluation results of the cross-sectional area (CSA) and fat infiltration of the lumbar deep paraspinal muscles. Read More

Z Naturforsch C J Biosci 2022 May 23. Epub 2022 May 23.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.

In this study, two novel series of thiazolylhydrazone derivatives containing 4-ethylpiperazine () and 4-methoxyphenylpiperazine (-) side chains were synthesized and their structures were characterized by spectral (H NMR, C NMR, and MS spectra) analyses. inhibitory activities of synthesized compounds against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were determined by Ellman method. According to the results, all compounds showed a weak inhibitory effect on AChE, while promising results were obtained on BChE. Read More

J Appl Behav Anal 2022 May 20. Epub 2022 May 20.

KU, Leuven.

Visual analysis and nonoverlap-based effect sizes are predominantly used in analyzing single case experimental designs (SCEDs). Although they are popular analytical methods for SCEDs, they have certain limitations. In this study, a new effect size calculation model for SCEDs, named performance criteria-based effect size (PCES), is proposed considering the limitations of 4 nonoverlap-based effect size measures, widely accepted in the literature and that blend well with visual analysis. Read More

Arch Pharm (Weinheim) 2022 May 18:e2200105. Epub 2022 May 18.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.

Within the scope of this study, new 2-{2-[(5-nitrothiophen-2-yl)methylene]hydrazinyl}thiazole derivatives (2a-j) were synthesized and investigated for their potential anticancer and enzyme inhibition activities. Spectroscopic techniques were used to determine the structures of substances. The anticancer activities of compounds were detected in A549 human lung carcinoma and L929 murine fibroblast cell lines, determining cytotoxicity, apoptosis, mitochondrial membrane integrity, and caspase-3 activation. Read More

Rev Assoc Med Bras (1992) 2022 May;68(5):627-631

Anadolu Medical Center, Department of Cardiovascular Surgery - Kocaeli, Turkey.

Objective: Fluid overload is associated with increased mortality and morbidity in pediatric cardiac surgery. In the pediatric age group, peritoneal dialysis might improve postoperative outcome with avoiding fluid overload and electrolyte imbalance. It preserves hemodynamic status with the advantage of passive drainage. Read More

J Chemother 2022 May 17:1-8. Epub 2022 May 17.

Medical Oncology, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.

Neoadjuvant chemotherapy (NACT) in gastroesophageal junction (GEJ) and gastric cancer (GC) was shown to improve survival in recent studies. We aimed to share our real-life experience of patients who received NACT to compare the efficacy and toxicity profile of different chemotherapy regimens in our country. This retrospective multicentre study included locally advanced GC and GEJ cancer patients who received NACT between 2007 and 2021. Read More

ACS Omega 2022 May 28;7(18):16152-16163. Epub 2022 Apr 28.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.

In this study, a series of novel 1,3,4-oxadiazole-benzimidazole derivatives were designed and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF-7, C6, HepG2, and HeLa, were evaluated by the MTT assay. The compounds , showed satisfactory potencies with much higher anticancer activity in comparison to the reference drug doxorubicin against the studied cancer cell lines. Read More

Bone Marrow Transplant 2022 May 13. Epub 2022 May 13.

Department of Hematology, Sorbonne University, Saint Antoine Hospital; INSERM UMR 938, Paris, France.

Non-T-cell depleted haploidentical hematopoietic cell transplantation (Haplo-HCT) is a unique transplantation setting in which several donors are available. We assessed the impact of donor kinship on outcome of Haplo-HCT with post-transplantation cyclophosphamide in a cohort of 717 acute leukemia patients. We compared sibling with parent donors in patients ≤45 years, and child with sibling donors in patients >45 years. Read More

J Pharm Biomed Anal 2022 Apr 25;216:114799. Epub 2022 Apr 25.

Ankara University, Faculty of Pharmacy, Department of Biochemistry, 06100, Anadolu, Ankara, Turkey.

In the present research, piroxicam entrapped core-shell lipid-polymer hybrid nanocarriers were developed and also evaluated in terms of nanoparticle features and cell-based in vitro efficacy on prostate cancer cells. Box-Behnken optimization approach was implemented to evaluate the impact of the input variables, namely phospholipid/PLGA ratio, total lipids/lecithin molar ratio, and piroxicam concentration, on two output variables: particle size and entrapment efficiency. Surface charge, size distribution, morphological structure of particles, drug release profiles, presence of outer lipid shell, thermal profile and possible interactions and storage stability of core-shell nanocarriers of piroxicam were studied as particle features. Read More

Environ Sci Pollut Res Int 2022 May 4. Epub 2022 May 4.

Department of Economics and Public Policy, Great Lakes Institute of Management, Gurugram, Haryana, 122413, India.

Latin America experiences an increasing urban primacy index and a rapid expansion of the financial system, putting direct pressure on the demand for resources to satisfy the consumption of large cities. We investigate the convergence of per capita biocapacity in 16 Latin America countries and evaluate the factors that influence its evolution over time. Specifically, we analyze the impact of the urban primacy index, economic progress, and the financial globalization index on the convergence of per capita biocapacity. Read More

Arch Pharm (Weinheim) 2022 May 3:e2200132. Epub 2022 May 3.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.

Carbonic anhydrase (CA) enzymes are involved in many physiological events. These enzymes, which contain Zn in their structure, can be easily inhibited by dithiocarbamate compounds. In addition, CA enzyme inhibitory activities are known in groups such as sulfonamide and methylsulfonyl. Read More

Bioorg Chem 2022 Apr 21;124:105822. Epub 2022 Apr 21.

Van Yüzüncü Yıl University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Van, Turkey.

The research in selective monoamine oxidases (MAO-A and MAO-B) inhibitors has been increased due to their therapeutic value for neurodegenerative diseases. In this study, 4-((2-(aryl)-4-oxoquinazolin-3(4H)-yl)amino)benzenesulfonamides were synthesized and their MAOs inhibition potentials were investigated applying in vitro fluorometric technique. The most potent compounds 7 and 8 against MAO-A had IC values of 0. Read More

Mikrobiyol Bul 2022 Apr;56(2):304-314

Anadolu Health Center Hospital, Clinic of Medical Microbiology, Kocaeli, Turkey.

Acute infectious gastroenteritis is a prevalent disease worldwide, and most of the cases are caused by viral pathogens. Many different viruses, including Rotavirus (RV), Norovirus, Adenovirus, and Astroviruses, are responsible for most acute viral gastroenteritis cases. According to the Centers for Disease Control and Prevention (CDC), viral gastroenteritis infections cause more than 200 000 child mortalities each year worldwide. Read More

Z Naturforsch C J Biosci 2022 Apr 27. Epub 2022 Apr 27.

Department of Pharmaceutical Chemistry, School of Pharmacy, İstanbul Medipol University, 34083 Istanbul, Turkey.

In this study, novel 4-(5-((2/3/4-substituted benzyl)thio)-4-(4-substituted phenyl)-4-1,2,4-triazol-3-yl)-2-(pyridin-3/4-yl)thiazoles were synthesized following a multi-step synthetic procedure. All the compounds were screened with a panel of gram positive/negative bacteria, yeasts, and molds for antimicrobial activity using the disc diffusion method. Then, the minimum inhibitor concentration (MIC) and the minimum bactericidal concentration (MBC) values of active compounds were determined against , , , and using the broth microdilution technique. Read More

Univers Access Inf Soc 2022 Apr 19:1-14. Epub 2022 Apr 19.

Department of Social Studies Education, College of Education, Bolu Abant İzzet Baysal University, 14030 Bolu, Turkey.

Three-dimensional printing, or 3D printing, has been used toward the educational, cultural, and social participation of individuals who are blind and partially sighted (BPS) by providing sensory access by touch. This study describes an example of the use of 3D printing technology to make museums accessible to visitors who are BPS by creating a three-dimensional printed artifacts museum (3D-PAM) that exhibits 3D printed replicas of artifacts from famous museums around the world. Specifically, the aim of the study is to identify the definitions of museums and the general experiences of museum visits by people who are BPS, to have them visit a 3D-PAM, and to unravel their reactions to this experience and their future suggestions for 3D-PAM. Read More

Bosn J Basic Med Sci 2022 Apr 17. Epub 2022 Apr 17.

Department of Medical Oncology, Faculty of Medicine, Bezmialem Vakif University Istanbul, Turkey.

Fluoropyrimidine+cisplatin/oxaliplatin+trastuzumab therapy is recommended for the first-line treatment of HER2-positive metastatic gastric adenocarcinoma. However, there is no comprehensive study on which platinum-based treatment should be preferred. This study aimed to compare the treatment response and survival characteristics of patients with HER2-positive metastatic gastric or gastroesophageal junction (GEJ) cancer who received fluorouracil, oxaliplatin, and leucovorin (mFOLFOX)+trastuzumab or cisplatin and fluorouracil (CF)+trastuzumab as first-line therapy. Read More

Curr Drug Deliv 2022 Apr 18. Epub 2022 Apr 18.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, 26470, Eskisehir, Turkey.

Background: A combination of antibiotics, including metronidazole (MET), ciprofloxacin (CIP), and minocycline (MINO), has been demonstrated to disinfect bacteria in necrotic teeth before regenerative processes. It has been presented clinically that antibiotic pastes may drive to possible stem cell death, difficulties in removing from the canal system, which can limit the regenerative procedure. This study was designed to (1) synthesize nanofibrous webs containing various concentrations of different medicaments (triple, double, and calcium hydroxide, Ca(OH)2), (2) coat this electrospun fibrous gutta-percha (GP) cones. Read More

Planta Med 2022 Apr 19. Epub 2022 Apr 19.

Department of Pharmacognosy, Anadolu University, Eskisehir, Turkey.

Origanum spp. are used both for culinary purposes and for their biological activities. In this study, commercially Origanum majorana, O. Read More

Toxicon 2022 Jul 11;213:1-6. Epub 2022 Apr 11.

Recep Tayyip Erdogan University, Faculty of Art and Science, Department of Biology, 53100, Rize, Turkey.

Due to increasing antibiotic resistance, there is an urgent need to find new antibiotic alternatives or supporters for the treatment of disease-causing pathogens. For this reason the aim of the study was examine the antimicrobial and antifungal activity of Anatolian (Anadolu) honey bee venom (HBV) against Gram-positive and Gram-negative bacteria and yeast-like fungi. At first step chemical analyses of HBV was performed by HPLC method. Read More

Leukemia 2022 Apr 12. Epub 2022 Apr 12.

Hematology Department, Institut Català d'Oncologia Hospitalet, IDIBELL, Universitat de Barcelona, Barcelona, Spain.

Hodgkin lymphoma (HL) patients who relapse after autologous-stem-cell- transplantation (auto-SCT) have traditionally had a poor prognosis. We analyzed 1781 adult HL patients who relapsed between 2006 and 2017 after a first auto-SCT. The 4-year overall survival (OS) after relapse continuously increased from 32% for patients relapsing in 2006-2008, to 63% for patients relapsing in 2015-2017 (p = 0. Read More

Molecules 2022 Mar 25;27(7). Epub 2022 Mar 25.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.

Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease that causes dementia in people aged 65 and over. In the present study, a series of thiadiazole hybrid compounds with benzothiazine derivatives as acetylcholinesterase inhibitors were developed and evaluated for their biological activity. The AChE and BChE inhibition potentials of all compounds were evaluated by using the in vitro Ellman method. Read More

Mol Divers 2022 Apr 9. Epub 2022 Apr 9.

Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Türkiye.

The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and hCAIs) remain key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity antiepileptic, anticancer, antiinfective, antiglaucoma, and diuretic effects. Here, it has been attempted to discover novel multi-target AChEIs and hCAIs that are highly potent, orally bioavailable, may be brain penetrant, and have higher effectiveness at lower doses than tacrine and acetazolamide. After detailed investigations both in vitro and in silico, novel N-substituted sulfonyl amide derivatives (6a-j) were determined to be highly potent inhibitors for AChE and hCAs (Ks are in the range of 23. Read More

J Cancer Res Clin Oncol 2022 Apr 5. Epub 2022 Apr 5.

Bakırçay University Cigli Education and Research Hospital, İzmir, Turkey.

Objectives: To compare the survival of first- and second-generation tyrosine kinase inhibitors (TKIs) in patients with rare EGFR exon 18 and exon 20 mutation-positive non-small cell lung cancer (NSCLC).

Materials And Methods: We retrospectively evaluated survival characteristics of 125 patients with EGFR exon 18 and exon 20 mutated NSCLC who received erlotinib or afatinib as first line treatment between 2012 and 2021 from 34 oncology centres. Since exon 20 insertion is associated with TKI resistance, these 18 patients were excluded from the study. Read More

Support Care Cancer 2022 Apr 4. Epub 2022 Apr 4.

Istanbul University - Cerrahpasa Florence Nightingale Nursing Faculty, Abide-i Hürriyet Cad, Caglayan 34403, Istanbul, Turkey.

Aim: This descriptive study was conducted to determine symptoms experienced at home in the early period by patients who received hematopoietic stem cell transplantation (HSCT), identify coping behaviors used by the patients in the management of symptoms and assess the quality of life of these patients.

Method: The study included 200 patients who had received HSCT at a private hospital in Kocaeli in Turkey between October 2017 and November 2018 and been discharged. The data of the study were collected by using a patient information and interview form developed by the researcher, the Memorial Symptom Assessment Scale and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30. Read More

Disaster Med Public Health Prep 2022 Mar 31:1-26. Epub 2022 Mar 31.

Assoc. Prof. (PhD), Department of Communication Design and Management, Faculty of Communication Sciences, Anadolu University.

Objective: This study, which aims to reveal the metaphorical perceptions of social media users regarding the term, "Covid-19," is in accordance with the phenomenological method.

Method: The phenomenological method was used in this study. In July 2020, a total of 125 social media users voluntarily participated in this research study and were asked to derive metaphors regarding the concept of Covid-19. Read More

Environ Sci Pollut Res Int 2022 Mar 29. Epub 2022 Mar 29.

Department of International Trade and Finance, Faculty of Economics and Administrative Sciences, Dumlupınar University, Kutahya, Turkey.

Green production is one of the major debates as environmental degradation poses threats globally. The paper attempts to explore the relationship between green production and environmental quality by using Economic Fitness approach. We develop a Green Complexity Index (GCI) dataset consisting of 290 traded green-labeled products and Economic Fitness Index (EFI) for the US states between 2002 and 2018. Read More

Res Pract Technol Enhanc Learn 2022 25;17(1):11. Epub 2022 Mar 25.

Beijing Normal University, Beijing, China.

This paper explores faculty's perspectives and use of open educational resources (OER) and their repositories across different countries by conducting a multiple case study to find similarities and differences between academics' awareness, perceptions and use of OER, as well as examining related aspects of institutional policy and quality that may influence individual views. Data were collected through nine expert reports on each country studied (Australia, Canada, China, Germany, Japan, South Africa, South Korea, Spain and Turkey) and were analyzed through qualitative content analysis using thematic coding. Findings show the impact on individual OER adoption with regard to the individual control of diverse factors by faculty members; of institutional policies and quality measures on the externally determined factors (by the institution); and of institutional professional development and provision of incentives in more internally determined factors (by the faculty members themselves). Read More

Perspect Behav Sci 2022 Mar 31;45(1):239-257. Epub 2021 Mar 31.

Department of Special Education, Recep Tayyip Erdogan University, 53100 Rize, Turkey.

Access to raw data of graphs presented in original articles to calculate the effect size of single-case research is a challenge for researchers conducting studies such as meta-analysis. Researchers typically use data extraction software programs to extract raw data from the graphs in articles. In this study, we aimed to analyze the validity and reliability of the PlotDigitizer software program, which is widely used in literature and an alternative to other data extraction programs, on computers with different operating systems. Read More

Transl Oncol 2022 Jun 23;20:101403. Epub 2022 Mar 23.

Division of Hematology, Department of Internal Medicine, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Fatih, Turkey. Electronic address: