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    1 OF 29

    Forensic applications of supercritical fluid chromatography - mass spectrometry.
    J Chromatogr B Analyt Technol Biomed Life Sci 2018 Apr 11;1086:184-196. Epub 2018 Apr 11.
    Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic. Electronic address:
    Achievements of supercritical fluid chromatography with mass spectrometric detection made in the field of forensic science during the last decade are reviewed. The main topics include analysis of traditional drugs of abuse (e.g. Read More

    Prevalence, Attitude, Knowledge, and Practice of Anabolic Androgenic Steroid (AAS) Use Among Gym Participants.
    Mater Sociomed 2018 Mar;30(1):49-52
    Internal Medicine, Diabetes, and Endocrinology Certified Clinical Densitometrist. Taif University School of Medicine, Taif, Saudi Arabia.
    Background: Anabolic steroids (AS) are synthetic testosterone derivatives that last longer than physiological androgens in the body. Anabolic-androgenic steroid (AAS) abuse is spreading among athletes. The aim of this study is to assess the knowledge, attitudes, and practices of gym participants in Saudi Arabia. Read More

    Procoagulant State in Current and Former Anabolic Androgenic Steroid Abusers.
    Thromb Haemost 2018 Apr 4;118(4):647-653. Epub 2018 Apr 4.
    Centre of Endocrinology and Metabolism, Department of Internal Medicine, Copenhagen University Hospitals, Herlev and Gentofte, Denmark.
    Background:  Anabolic androgenic steroid (AAS) abusers are considered at increased risk of cardiovascular morbidity and mortality. We hypothesized that current and former AAS abuse would induce a procoagulant shift in the haemostatic balance.

    Methods:  Men 18 to 50 years of age were included as current AAS abusers, former AAS abusers or controls. Read More

    Undetectable high-density lipoprotein cholesterol in acute malaria.
    J Clin Lipidol 2018 Mar 9. Epub 2018 Mar 9.
    Guy's, St Thomas' and Lewisham and Greenwich Trust, St. Thomas' Hospital, London, United Kingdom.
    We report the case of a 39-year-old West African man in whom high-density lipoprotein cholesterol (HDL-C) was identified as undetectable at <0.08 mmol/L. Total cholesterol in the same sample was 2. Read More

    Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse.
    Case Rep Pulmonol 2018 23;2018:5202173. Epub 2018 Jan 23.
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
    Pulmonary alveolar proteinosis (PAP) is a rare lung disorder in which defects in alveolar macrophage maturation or function lead to the accumulation of proteinaceous surfactant in alveolar space, resulting in impaired gas exchange and hypoxemia. PAP is categorized into three types: hereditary, autoimmune, and secondary. We report a case of secondary PAP in a 47-year-old man, whose risk factors include occupational exposure to inhaled toxins, especially aluminum dust, the use of anabolic steroids, and alcohol abuse, which in mice leads to alveolar macrophage dysfunction through a zinc-dependent mechanism that inhibits granulocyte macrophage-colony stimulating factor (GM-CSF) receptor signalling. Read More

    Prevalence and awareness of Anabolic Androgenic Steroids (AAS) among gymnasts in the western province of Riyadh, Saudi Arabia.
    Electron Physician 2017 Dec 25;9(12):6050-6057. Epub 2017 Dec 25.
    Consultant Family Medicine and EBM, MRCGP. Educ. Certify, Dundee University, United Kingdom.
    Background: Anabolic Androgenic Steroids (AAS) are synthetic derivatives of the male sex hormone (testosterone) that are increasingly used by athletes as performance enhancing drugs to increase muscle mass and strength. Multiple health adverse effects may be caused by its non-medical use. Several international and regional studies showed the high prevalence of AAS usage and low level of awareness of it among different populations. Read More

    Combined chemical and biotechnological production of 20βOH-NorDHCMT, a long-term metabolite of Oral-Turinabol (DHCMT).
    J Inorg Biochem 2018 Jun 26;183:165-171. Epub 2018 Feb 26.
    Tianjin University, Health Science Platform, School of Pharmaceutical Science and Technology, Tianjin, China. Electronic address:
    Anabolic androgenic steroids (AAS) are misused very frequently in sport competitions as performance enhancing agents. One of the doping compounds that has been detected with increased frequency in the last few years is dehydrochloromethyltestosterone (DHCMT, 4-chloro-17β-hydroxy-17α-methylandrosta-1,4-dien-3-one; brand name Oral Turinabol). The long-term DHCMT metabolite 20βOH-NorDHCMT (4-chloro-17β-hydroxymethyl-17α-methyl-18-norandrosta-1,4,13-trien-3-one) was reported earlier to be detectable in urine samples for more than 22 days after DHCMT administration; however, purified reference material was not available so far. Read More

    β-2 Agonists as Misusing Drugs? Assessment of both Clenbuterol- and Salbutamol-related European Medicines Agency Pharmacovigilance Database Reports.
    Basic Clin Pharmacol Toxicol 2018 Mar 2. Epub 2018 Mar 2.
    Psychopharmacology, Drug Misuse, and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK.
    A recent years' increase in misusing levels of image- and performance- enhancing drugs (IPEDs) has been observed. Out of these drugs, beta-2 agonists have recently emerged for their potential of misuse, especially for slimming and bodybuilding purposes. To this perspective, clenbuterol ('the size zero pill') has been reported as being both popular and widely available from the illegal market. Read More

    Adverse effects of doping with anabolic androgenic steroids (AAS) in competitive athletics, recreational sports and bodybuilding.
    Minerva Endocrinol 2018 Feb 19. Epub 2018 Feb 19.
    Centre of Reproductive Medicine and Andrology, University Hospital Münster, Muenster, Germany -
    Despite the fact that sports organizations and legislators have introduced various mechanisms to discourage athletes from using performance and appearance enhancing substances a high percentage of athletes admits to their unabated application. In competitive athletics, bodybuilding and in recreational sports anabolic androgenic steroids (AAS) continue to be the substances most abused. This review summarizes the side effects of AAS abuse on organs and system functions in both sexes. Read More

    Impact of Health Authority Control Measures Aimed at Reducing the Illicit Use of Anabolic-Androgenic Steroids.
    Eur Addict Res 2018 15;24(1):28-36. Epub 2018 Feb 15.
    Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Santiago de Compostela and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP) Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
    Objective: To evaluate two interventions on anabolic-androgenic-steroids (AAS) dispensation in retail pharmacies.

    Material And Methods: The study was conducted in a north-western region of Spain. Data were the AAS supplied by wholesale drug distributors to retail pharmacies over a period of 102 months. Read More

    Public health impact of androgens.
    Curr Opin Endocrinol Diabetes Obes 2018 Jan 24. Epub 2018 Jan 24.
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Boston, Massachusetts, USA.
    Purpose Of Review: To summarize recent findings regarding the public health impact of androgen abuse.

    Recent Findings: Abuse of androgens (also called 'anabolic-androgenic steroids') has grown into a major worldwide substance abuse problem involving tens of millions of individuals, of whom about 98% are men. Most androgen abusers are still under age 50 today, and thus, the long-term effects of these drugs are only beginning to be understood. Read More

    Potential of saliva steroid profiling for the detection of endogenous steroid abuse: Reference thresholds for oral fluid steroid concentrations and ratios.
    Anal Chim Acta 2018 Jan 11;999:1-12. Epub 2017 Nov 11.
    Ghent University, Department of Clinical Chemistry, Microbiology and Immunology, Doping Control Laboratory, Technologiepark 30 B, B-9052 Zwijnaarde, Belgium.
    Urine and blood samples are the primary matrices for the detection of exogenous substances in doping control and toxicology. Although these matrices are, in general, very suitable for a wide range of substances, they do show some issues in particular cases. Here, alternative matrices may provide an answer. Read More

    Anabolic-androgenic steroids (AAS) increase sensitivity to uncertainty by inhibition of dopamine D1 and D2 receptors.
    Psychopharmacology (Berl) 2018 Apr 14;235(4):959-969. Epub 2017 Dec 14.
    Department of Integrated Anatomical Sciences, Keck School of Medicine of the University of Southern California, 1333 San Pablo St., BMT 401, Los Angeles, CA, 90033, USA.
    Background: Anabolic-androgenic steroid abuse is implicated in maladaptive behaviors such as impaired cognition in humans. In a rat model, our lab has shown that testosterone decreases preference for a large/uncertain reward in probability discounting. Other studies have shown that androgens decrease dopamine D1 and D2 receptors in the nucleus accumbens shell, a region important for decision-making behavior in probability discounting. Read More

    The interaction effects of resistance training and sustanon abuse on liver antioxidant activities and serum enzymes in male rats.
    Interv Med Appl Sci 2017 Sep;9(3):178-183
    Department of Biology, Faculty of Basic Sciences, University of Guilan, Rasht, Iran.
    Background: Anabolic-androgenic steroids (AAS) are synthetic drugs derived from testosterone, the uncontrolled usage of which may lead to serious side effects. Previous studies have shown that resistance training (RT) is the main exercise modality practiced by AAS abusers. Thus, this work was carried out to evaluate the hepatotoxic effects of sustanon (Su) as an example of AAS in trained male rats. Read More

    Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats.
    Braz J Med Biol Res 2017 Nov 17;51(1):e6388. Epub 2017 Nov 17.
    Laboratório de Neuropsicofarmacologia, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara, SP, Brasil.
    The abuse of psychoactive drugs is considered a global health problem. During the last years, a relevant number of studies have investigated the relationship between anabolic-androgenic steroids (AAS) and other psychoactive drugs. AAS, such as testosterone, can cause a dependence syndrome that shares many features with the classical dependence to psychoactive substances. Read More

    The role of hormones in muscle hypertrophy.
    Phys Sportsmed 2018 Feb 25;46(1):129-134. Epub 2017 Nov 25.
    c Graduate Schools of Health and Sport Science , Nippon Sport Science University , Tokyo , Japan.
    Anabolic-androgenic steroids (AAS) and other hormones such as growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have been shown to increase muscle mass in patients suffering from various diseases related to muscle atrophy. Despite known side-effects associated with supraphysiologic doses of such drugs, their anabolic effects have led to their widespread use and abuse by bodybuilders and athletes such as strength athletes seeking to improve performance and muscle mass. On the other hand, resistance training (RT) has also been shown to induce significant endogenous hormonal (testosterone (T), GH, IGF-1) elevations. Read More

    Analysis of Elevated Levels of Nandrolone Decanoate Induced Cytochrome- P450 Alterations in Mice.
    Drug Metab Lett 2017 ;11(2):86-92
    Department of Zoology, Faculty of Sciences, Cotton College, Guwahati, Assam, India.
    Background: Frequent recreational use of Anabolic Androgenic Steroids (AAS) is an instance of substance abuse which mimics the status of a natural hormone and upon prolonged exposure may lead to adverse drug reactions. These adverse drug reactions proceed in a manner so as to alter the normal metabolism of an enzyme mediated pathway such as the Cytochrome P450 (CYP) family of enzymes.

    Objective: The present study was conducted to investigate the impact of overuse of Nandrolone Decanoate (ND), an AAS, upon CYP enzyme activity and a CYP gene, belonging to CYP1 family. Read More

    Urine reference intervals for human chorionic gonadotropin (hCG) isoforms by immunoextraction-tandem mass spectrometry to detect hCG use.
    Drug Test Anal 2017 Nov 3. Epub 2017 Nov 3.
    UCLA Olympic Analytical Laboratory, Department of Pathology & Laboratory Medicine, Geffen School of Medicine, UCLA Health System, Los Angeles, California.
    Human chorionic gonadotropin (hCG) stimulates testosterone production by the testicles and can normalize suppressed testosterone concentrations in males following prolonged anabolic steroid use. Because of the potential for abuse by males, hCG is on the World Anti-Doping Agency (WADA) list of prohibited substances. The majority of WADA-accredited laboratories measure urinary hCG using an automated immunoassay. Read More

    Applicability of an innovative steroid-profiling method to determine synthetic growth promoter abuse in cattle.
    J Steroid Biochem Mol Biol 2017 11 13;174:265-275. Epub 2017 Oct 13.
    RIKILT Wageningen University & Research, P.O. Box 230, Wageningen, The Netherlands.
    A robust LC-MS/MS method was developed to quantify a large number of phase I and phase II steroids in urine. The decision limit is for most compounds lower than 1ngml with a measurement uncertainty smaller than 30%. The method is fully validated and was applied to assess the influence of administered synthetic steroids and beta-agonists on the steroidogenesis. Read More

    Epidemiology of cardiovascular disease in young individuals.
    Nat Rev Cardiol 2018 Apr 12;15(4):230-240. Epub 2017 Oct 12.
    Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, Massachusetts 01702-5827, USA.
    In the past 2 decades, a high prevalence of risk factors for cardiovascular disease, such as obesity, physical inactivity, and poor diet, has been observed among young individuals living in developed countries. The rate of substance abuse (opioids, cocaine, electronic cigarettes, and anabolic steroids) is also increasing among young adults, whereas cigarette smoking might be declining. Among younger individuals (aged 18-50 years), the incidence of cardiovascular diseases over the same time period has either been steady or has increased, in contrast to the trend towards a lower incidence of cardiovascular disease in adults aged >50 years. Read More

    Long-term anabolic steroids in male bodybuilders induce cardiovascular structural and autonomic abnormalities.
    Clin Auton Res 2018 Apr 10;28(2):231-244. Epub 2017 Oct 10.
    Department of Physiology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil.
    Objective: The aims of this study were to examine the hypothesis that users of anabolic androgenic steroids (AAS) would have cardiac autonomic disorders and that there is a correlation between sympathetic modulation, high blood pressure (BP) and alterations to cardiac dimensions.

    Methods: Forty-five male subjects were enrolled in the study. They were categorized into three groups comprising bodybuilders actively using AAS (AAS users; n = 15), bodybuilders who had never used AAS (nonusers; n = 15) and age-paired healthy sedentary controls (n = 15). Read More

    Severe hypokalemic paralysis and rhabdomyolysis occurring after binge eating in a young bodybuilder: Case report.
    Medicine (Baltimore) 2017 Oct;96(40):e8251
    aDepartment of Internal Medicine, Changwon Gyeongsang National University Hospital, Changwon-si bDepartment of Internal Medicine, Gyeongsang National University Hospital cDepartment of Internal Medicine, College of Medicine, Gyeongsang National University dInstitute of Health Science, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, South Korea.
    Rationale: Severe hypokalemia can be a potentially life-threatening disorder and is associated with variable degrees of skeletal muscle weakness.

    Patient Concerns: We report a case of severe hypokalemic paralysis and rhabdomyolysis in a 28-year-old bodybuilder. He was admitted to the emergency room due to progressive paralysis in both lower extremities, which had begun 12 hours earlier. Read More

    The Role of Anabolic Androgenic Steroids in Disruption of the Physiological Function in Discrete Areas of the Central Nervous System.
    Mol Neurobiol 2017 Oct 2. Epub 2017 Oct 2.
    Department of Clinical and Experimental Medicine, Section of Forensic Pathology, University of Foggia, Ospedale Colonnello D'Avanzo, Foggia, Italy.
    Anabolic-androgenic steroids (AAS) abuse is often associated with a wide spectrum of adverse effects. These drugs are frequently abused by adolescents and athletes for esthetic purposes, as well as for improvement of their endurance and performances. In this literature review, we evaluated the correlation between AAS and anxiety or aggression. Read More

    Increased blood pressure and aortic stiffness among abusers of anabolic androgenic steroids: potential effect of suppressed natriuretic peptides in plasma?
    J Hypertens 2018 Feb;36(2):277-285
    Centre of Endocrinology and Metabolism, Department of Internal Medicine.
    Background: Abuse of anabolic androgenic steroids (AAS) is prevalent among recreational athletes and adverse effects on blood pressure (BP) and arterial stiffness could be substantial. Testosterone decreases natriuretic peptides which are key components in BP-regulation and may impair BP-homeostasis in AAS abusers.

    Objective: To investigate BP and aortic stiffness in relation to natriuretic peptides among current AAS abusers, former AAS abusers and controls. Read More

    Sexual orientation, bullying for being labeled gay or bisexual, and steroid use among US adolescent boys.
    J Health Psychol 2018 Mar 12;23(4):608-617. Epub 2017 Feb 12.
    Texas Tech University, USA.
    Use of anabolic-androgenic steroids is a public health concern for adolescent boys. This study examined bullying based on being labeled gay/bisexual and steroid use among US adolescent boys, including sexual orientation disparities. Data from 2660 boys from the 2015 Youth Behavior Risk Survey were used. Read More

    Advanced methods for analysis of testosterone.
    Curr Med Chem 2017 Jul 24. Epub 2017 Jul 24.
    Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021, Bucharest-6. Romania.
    Testosterone is the principal endogenous androgenic-anabolic steroid in humans. The levels of testosterone in the human body are correlated with many hormonal disorders (hypogonadism, impotence, etc) mostly in men, and with many types of diseases such as: prostate cancer, metabolic syndrome, obesity, cardiovascular diseases and so on. Testosterone is extensively used among sportsmen willing to increase strength, aggressiveness, and recovery; making it the most commonly reported substance in steroid abuse. Read More

    Information sought, information shared: exploring performance and image enhancing drug user-facilitated harm reduction information in online forums.
    Harm Reduct J 2017 Jul 21;14(1):48. Epub 2017 Jul 21.
    Queensland University of Technology, Brisbane, Australia.
    Background: There is good evidence to suggest that performance and image enhancing drug (PIED) use is increasing in Australia and that there is an increase in those using PIEDs who have never used another illicit substance. Peers have always been an important source of information in this group, though the rise of the Internet, and the increased use of Internet forums amongst substance consumers to share harm reduction information, means that PIED users may have access to a large array of views and opinions. The aim of this study was to explore the type of information that PIED users seek and share on these forums. Read More

    Ionization and collision induced dissociation of steroid bisglucuronides.
    J Mass Spectrom 2017 Nov;52(11):759-769
    Barcelona Antidoping Laboratory, Doping Control Research Group, IMIM, Hospital del Mar Medical Research Institute, Doctor Aiguader 88, 08003, Barcelona, Spain.
    Studies on steroid metabolism are of utmost importance to improve the detection capabilities of anabolic androgenic steroids (AASs) misuse in sports drug testing. In humans, glucuronoconjugates are the most abundant phase II metabolites of AAS. Bisglucuronidation is a reaction where two separated functional groups on the same molecule are conjugated with glucuronic acid. Read More

    Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids.
    PLoS One 2017 18;12(7):e0180409. Epub 2017 Jul 18.
    Department of Anatomy and Neurobiology, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico, United States of America.
    The abuse of anabolic androgenic steroids (AAS) has been considered a major public health problem during decades. Supraphysiological doses of AAS may lead to a variety of neuroendocrine problems. Precisely, the hypothalamic-pituitary-gonadal (HPG) axis is one of the body systems that is mainly influenced by steroidal hormones. Read More

    Do anabolic-androgenic steroids have performance-enhancing effects in female athletes?
    Mol Cell Endocrinol 2018 Mar 12;464:56-64. Epub 2017 Jul 12.
    Section of Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
    Doping with anabolic-androgenic steroids (AAS) is common among both male and female athletes and is a growing public health problem. Review of historical data of systematic state-sponsored doping programs implemented by the German Democratic Republic in elite female athletes and from clinical trials of testosterone administration in non-athlete women suggests that AAS have ergogenic effects in women. The use of AAS in female athletes has been associated with adverse effects that include acne, hirsutism, deepening of the voice and menstrual disturbances; life-threatening adverse effects such as cardiac arrhythmias and sudden death have also been reported. Read More

    Synchronous Solid Pseudopapillary Tumor and Insulinoma in an Adolescent MEN1 Patient Presenting with Diagnostic Dilemmas.
    J Clin Res Pediatr Endocrinol 2017 Dec 30;9(4):375-379. Epub 2017 Jun 30.
    İstanbul University İstanbul Faculty of Medicine, Department of Adolescent Medicine and Pediatrics, İstanbul, Turkey.
    Multiple endocrine neoplasia (MEN1) is a rare autosomal dominant disorder characterized by primary hyperparathyroidism, enteropancreatic neuroendocrine tumors, and anterior pituitary adenomas. A 16-year-old male presented to the emergency outpatient clinic with tonic convulsions. Physical examination in the postconvulsive period was unremarkable and revealed a muscular, postpubertal adolescent. Read More

    Adverse health effects of androgen use.
    Mol Cell Endocrinol 2018 Mar 9;464:46-55. Epub 2017 Jun 9.
    Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
    Anabolic androgenic steroids (AAS) are performance enhancing drugs commonly used by athletes and bodybuilders to improve appearance and athletic capability. Unfortunately, these testosterone derivatives can be associated with serious and potentially irreversible side effects, and can impact multiple organ systems. It is important that physicians be familiar with these adverse consequences so that they can appropriately counsel patients whom they suspect of AAS-abuse. Read More

    Inhibitory Effects of Diclofenac on Steroid Glucuronidation In Vivo Do Not Affect Hair-Based Doping Tests for Stanozolol.
    Molecules 2017 Jun 12;22(6). Epub 2017 Jun 12.
    School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston upon Thames, London KT1 2EE, UK.
    In vitro studies show that diclofenac inhibits enzymatic steroid glucuronidation. This study was designed to investigate the influence of diclofenac on the excretion of stanozolol and 3'-hydroxystanozolol via analyses in hair, blood and urine in vivo in a rat study. Brown Norway rats were administered with stanozolol (weeks 1-3) and diclofenac (weeks 1-6). Read More

    The role of neuropeptide-Y in nandrolone decanoate-induced attenuation of antidepressant effect of exercise.
    PLoS One 2017 5;12(6):e0178922. Epub 2017 Jun 5.
    Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
    Since the increased prevalence of anabolic androgenic steroids abuse in last few decades is usually accompanied by various exercise protocols, the scope of our study was to evaluate the effects of chronic nandrolone decanoate administration in supraphysiological dose and a prolonged swimming protocol (alone and simultaneously with nandrolone decanoate) on depressive state in male rats. Simultaneously, we investigated the possible alterations in neuropeptide Y (NPY) content in blood and the hippocampus, in order to determine the role of NPY in the modulation of depressive-like behavior.Exercise induced antidepressant effects in tail suspension test (decrease of the total duration of immobility), as well as significant increase in the number of hippocampal NPY-interneurons in CA1 region. Read More

    Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroid Use.
    Circulation 2017 May;135(21):1991-2002
    From Cardiovascular Performance Program, Division of Cardiology, Massachusetts General Hospital, Boston (A.L.B., R.B.W.); Department of Medicine, Harvard Medical School, Boston, MA (A.L.B., R.B.W.); Biological Psychiatry Laboratory and Psychiatric Epidemiology Research Program, McLean Hospital, Belmont, MA (G.K., J.I.H., H.G.P.); Department of Psychiatry, Harvard Medical School, Boston, MA (G.K., J.I.H., H.G.P.); Cardiac MR PET CT Program, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, Boston (M.T.L., U.H.).
    Background: Millions of individuals have used illicit anabolic-androgenic steroids (AAS), but the long-term cardiovascular associations of these drugs remain incompletely understood.

    Methods: Using a cross-sectional cohort design, we recruited 140 experienced male weightlifters 34 to 54 years of age, comprising 86 men reporting ≥2 years of cumulative lifetime AAS use and 54 nonusing men. Using transthoracic echocardiography and coronary computed tomography angiography, we assessed 3 primary outcome measures: left ventricular (LV) systolic function (left ventricular ejection fraction), LV diastolic function (early relaxation velocity), and coronary atherosclerosis (coronary artery plaque volume). Read More

    High-dose testosterone enanthate supplementation boosts oxidative stress, but exerts little effect on the antioxidant barrier in sedentary adolescent male rat liver.
    Pharmacol Rep 2017 Aug 11;69(4):673-678. Epub 2017 Mar 11.
    Department of Experimental Pharmacology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland.
    Background: Anabolic-androgenic steroids abuse is on the rise among adolescent boys and young men, mostly in those seeking a 'shortcut' to an improved body image. This approach is associated with the risk of severe adverse health effects, some of which involve the liver and are linked to hepatic oxidative stress. Testosterone and its esters is a cornerstone of most anabolic-androgenic steroid stacking protocols. Read More

    Insulin sensitivity in relation to fat distribution and plasma adipocytokines among abusers of anabolic androgenic steroids.
    Clin Endocrinol (Oxf) 2017 Sep 8;87(3):249-256. Epub 2017 Jun 8.
    Center of Endocrinology and Metabolism, Department of Internal Medicine, Copenhagen University Hospitals, Herlev and Gentofte, Denmark.
    Objective: Abuse of anabolic androgenic steroids (AAS) is prevalent among young men, but information regarding effects on insulin sensitivity and fat distribution is limited. The objective was to investigate insulin sensitivity in relation to fat distribution and adipocytokines among current and former AAS abusers compared with controls.

    Design: Cross-sectional study among men involved in recreational strength training. Read More

    Muscle dysmorphia: detection of the use-abuse of anabolic adrogenic steroids in a Spanish sample.
    Adicciones 2017 Jul 14;0(0):853. Epub 2017 Jul 14.
    Universidad de Castilla-La Mancha. Facultad de Educación. Departamento de Educación Física.
    Debido a una distorsión en la imagen corporal, las personas que padecen Dismorfia Muscular se perciben menos musculosas de lo que son en realidad. Con el fin de aumentar su musculatura, algunas de estas personas hacen uso de hormonas cuya función principal es la del aumento del tamaño muscular. Por lo que el objetivo de este estudio es conocer la prevalencia del uso de hormonas en personas afectadas por Dismorfia Muscular. Read More

    Ventricular androgenic-anabolic steroid-related remodeling: an immunohistochemical study.
    Int J Legal Med 2017 Nov 21;131(6):1589-1595. Epub 2017 Apr 21.
    Department of Medicine and Surgery, Via Gramsci 14, 43126, Parma, Italy.
    Background: Several fatal cases of bodybuilders, following a myocardial infarction after long exposure to androgenic-anabolic steroids (AAS), are reported. In recent years, evidence has emerged of cases of heart failure related to AAS consumption, with no signs of coronary or aorta atherosclerosis. This study aims to further investigate the pathogenesis of the ventricular AAS-related remodeling performing immunohistochemistry (IHC). Read More

    Somatic effects of AAS abuse: A 30-years follow-up study of male former power sports athletes.
    J Sci Med Sport 2017 Sep 21;20(9):814-818. Epub 2017 Mar 21.
    Department of Surgical Sciences, Forensic Medicine, Uppsala University, Sweden.
    Objectives: The aim of the present study was to investigate the association between somatic health and former abuse of AAS in former elite male athletes 30 years after the end of their active sports career.

    Design: Retrospective follow-up study.

    Methods: N=996 former elite male athletes were sent a questionnaire concerning sociodemographic variables, previous and past sport activity and lifetime prevalence of seeking professional help for health problems. Read More

    Hepatotoxicity associated with illicit use of anabolic androgenic steroids in doping.
    Eur Rev Med Pharmacol Sci 2017 03;21(1 Suppl):7-16
    Department of Therapeutic Research and Medicines Evaluation, Drug Abuse and Doping Unit, Istituto Superiore di Sanità, Rome, Italy.
    Anabolic Androgenic Steroids (AAS) abuse and misuse is nowadays a harmful habit involving both professional or recreational athletes, as well as general population. AAS are also frequently present in over-the-counter dietary supplements without being declared in the list of ingredients, leaving consumers unaware of the risks of adverse effects. Indeed, health risks of AAS consumption in pharmaceutical preparations or dietary complements seem still underestimated and under-reported. Read More

    Abuse of anabolic agents in beef cattle: Could bile be a possible alternative matrix?
    Food Chem 2017 Aug 15;229:188-197. Epub 2017 Feb 15.
    Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche, Via G. Salvemini 1, I-06126 Perugia, Italy. Electronic address:
    European Union prohibited the use of anabolic agents in food producing animals since 1988. An efficient control of abuses is guaranteed not only by highly performing analytical methods, but also by knowledge of metabolic pathways, kinetics of elimination and tissue distribution. To obtain data concerning metabolites production and accumulation in bile, two typical growth promoting treatments are carried out in cattle. Read More

    Alterations of the oxidative status in rat hippocampus and prodepressant effect of chronic testosterone enanthate administration.
    Mol Cell Biochem 2017 Sep 24;433(1-2):41-50. Epub 2017 Mar 24.
    Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia.
    In a last few decades, anabolic-androgenic steroids (AASs) abuse has become serious health concern especially among adolescents. AASs abuse has been reported to be involved in pathogenesis of various mood disorders, including depression. In order to evaluate the effects of chronic (6 weeks) testosterone enanthate (TE) treatment in supraphysiological dose and exercise on depression-like behavior in rats, 32 male rats were divided into four groups: control (C), testosterone enanthate (T, 20 mg/kg/w, s. Read More

    Polypharmacy, Infectious Diseases, Sexual Behavior, and Psychophysical Health Among Anabolic Steroid-Using Homosexual and Heterosexual Gym Patrons in San Francisco's Castro District.
    Subst Use Misuse 2017 Jun 15;52(7):959-968. Epub 2017 Mar 15.
    c Biological Psychiatry Laboratory , McLean Hospital , Belmont , Massachusetts , USA.
    Background: Limited studies based in England and Australia reported misuse of anabolic-androgenic steroids (AAS) among homosexual men to enhance body image. Anecdotally, AAS are also being misused by homosexual men in the United States. Since many AAS and certain performance enhancing drugs (PEDs) are administered via injection, this poses a potential vector for the spread of infectious disease in an already at-risk population. Read More

    Identification and characterization of novel long-term metabolites of oxymesterone and mesterolone in human urine by application of selected reaction monitoring GC-CI-MS/MS.
    Drug Test Anal 2017 Nov 12;9(11-12):1673-1684. Epub 2017 May 12.
    Department of Clinical Chemistry, Microbiology and Immunology, Doping Control Laboratory, Ghent University, Technologiepark 30 B, B-9052, Zwijnaarde, Belgium.
    The search for metabolites with longer detection times remains an important task in, for example, toxicology and doping control. The impact of these long-term metabolites is highlighted by the high number of positive cases after reanalysis of samples that were stored for several years, e.g. Read More

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