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Neurology 2022 May 27. Epub 2022 May 27.

Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA

Background And Objectives: Motor speech function, including speech timing, is a key domain for diagnosing non-fluent/agrammatic variant primary progressive aphasia (nfvPPA). Yet, standard assessments employ subjective, specialist-dependent evaluations, undermining reliability and scalability. Moreover, few studies have examined relevant anatomo-clinical alterations in patients with pathologically-confirmed diagnoses. Read More

Neurology 2022 May 27. Epub 2022 May 27.

Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Background And Objectives: The genetic characteristics and correlations of hippocampal volume and plasm Aβ, probable endophenotypes for dementia, remain to be explored in Chinese community cohort. Using whole-exome sequencing and SNP-array genotyping, we sought to identify rare and common variants and genes influencing these two endophenotypes, and calculate their heritability and genetic correlation.

Methods: Association analyses with both whole-exome sequencing and SNP-array genotyping data were performed for hippocampal volumes and plasm Aβ with mixed-effect linear regression model adjusted for sex, age, and total intracranial volume or ε4 while considering familial relatedness. Read More

Neurology 2022 May 27. Epub 2022 May 27.

Department of Medicine, University of Otago Wellington, New Zealand

Background And Objective: International evidence shows that patients treated at non-urban hospitals experience poorer access to key stroke interventions. Evidence whether this results in poorer outcomes is conflicting and generally based on administrative or voluntary registry data. The aim of this study was to use prospective high-quality comprehensive nationwide patient level data to investigate the association between hospital geography and stroke patient outcomes and access to best practice stroke care in New Zealand. Read More

Br J Sports Med 2022 May 27. Epub 2022 May 27.

Applied Physiology & Nutrition Research Group, Laboratory of Assessment and Conditioning in Rheumatology, Universidade de Sao Paulo, Sao Paulo, Brazil

Objective: To describe acute/postacute COVID-19 presentations in athletes.

Design: Systematic review and meta-analysis.

Data Sources: The search was conducted in four databases (MEDLINE, EMBASE, SCOPUS, SPORTDiscus) and restricted to studies published from 2019 to 6 January 2022. Read More

Clin Nutr ESPEN 2022 Jun 20;49:92-102. Epub 2022 Apr 20.

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK; Paediatric Intensive Care Unit, Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK; School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.

Background & Aims: The term enteral feeding intolerance (FI) is frequently used in clinical practice and the literature, yet there is no standardised definition. FI is often quoted as a reason for failure to meet enteral nutrition (EN) targets but the lack of a consensus definition precludes accurate estimates of prevalence, predictors and clinical outcomes associated with FI. A systematic review was performed of studies in adult critical care patients to evaluate the definitions, relative risk, predictors and clinical outcomes of FI and to propose a uniform definition. Read More

Clin Nutr ESPEN 2022 Jun 17;49:529-535. Epub 2022 Feb 17.

Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.

Background And Aim: Clinicians who understand how the body responds to exercise, how aerobic training enhances cardiovascular fitness and the benefits and essentials of prescribing aerobic exercise can effectively encourage patients to be active. Deep-frying is a standard cooking method accompanied by the production of carcinogenesis substances such as acrolein. Acrolein is a toxic byproduct of lipid peroxidation involved in the development of pulmonary, cardiac, and neurodegenerative diseases. Read More

Clin Nutr ESPEN 2022 Jun 24;49:504-509. Epub 2022 Feb 24.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran, Iran. Electronic address:

Background & Aims: One of the essential parameters of athletes that enhancing fitness and success rate in sports career is body composition. Additionally, perfect performance of athletes is significantly influenced by training and dietary intake. This study aimed to determine the association between the dietary inflammatory index (DII) and body composition among Iran's Paralympic athletes with hemodialysis and hemophilia. Read More

Clin Nutr ESPEN 2022 Jun 24;49:499-503. Epub 2022 Feb 24.

Postgraduate Program in Health and Behavior, Catholic University of Pelotas, Brazil; Dialysis and Transplantation Unit, University Hospital São Francisco de Paula, Catholic University of Pelotas, Brazil. Electronic address:

Introduction: The hydration status is a predictor of survival in critically ill patients. However, it is unclear whether this association depends on the patient clinical condition. This study was designed to analyze the impact of hydration status on survival of critically ill patients with acute kidney injury (AKI) with or without sepsis. Read More

Clin Nutr ESPEN 2022 Jun 4;49:474-482. Epub 2022 Mar 4.

Department of Intensive Care Medicine, Gelderse Vallei Hospital, Willy Brandtlaan 10, Ede, 6716 RP, the Netherlands; Wageningen University& Research, Division of Human Nutrition and Health, Stippeneng 4, Wageningen, 6708 WE, the Netherlands. Electronic address:

Background: A large proportion of hospitalised COVID-19 patients are overweight. There is no consensus in the literature on how lean body mass (LBM) can best be estimated to adequately guide nutritional protein recommendations in hospitalised patients who are not at an ideal weight. We aim to explore which method best agrees with lean body mass as measured by bioelectric impedance (LBM) in this population. Read More

Clin Nutr ESPEN 2022 Jun 4;49:459-465. Epub 2022 Mar 4.

Clinical Nutrition, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.

Background: Retroperitoneal sarcoma (RPS) is a rare tumour that can reach exceptionally large size at diagnosis and affects body weight with its volume. We investigated the risk of nutritional status misclassification based on the Global Leadership Initiative on Malnutrition (GLIM) criteria in RPS patients.

Methods: We retrospectively analyzed the baseline data of patients with primary RPS including anthropometry, Malnutrition Universal Screening Tool (MUST) score and skeletal muscle index (SMI) calculated on preoperative CT scan. Read More

Clin Nutr ESPEN 2022 Jun 11;49:449-458. Epub 2022 Mar 11.

Centre of Active and Healthy Ageing, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark.

Background & Aims: Physical frailty may compromise physical function and reduce self-reliance in community-dwelling older adults. We investigated if nutritional risk factors and protein intake were associated with physical frailty in community-dwelling adults.

Methods: This cross-sectional study combined data from two studies in community-dwelling adults ≥65 years. Read More

Clin Nutr ESPEN 2022 Jun 17;49:436-441. Epub 2022 Mar 17.

Endocrinology and Nutrition Department, Hospital Clínic de Barcelona, Barcelona, Spain; Institut D'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain. Electronic address:

Background And Aims: Evidence on the occurrence of low skeletal muscle mass (low-SMM) following bariatric surgery (BS) as well as on the impact of low-SMM antedating BS on post-surgical body composition (BC) are scant. In this context, we aimed to prospectively evaluate the prevalence of low-SMM prior to and up to 5 years after BS, and to evaluate pre-surgical low-SMM as an independent risk factor for the presence of low-SMM after BS.

Methods: Retrospective analysis of prospectively collected database. Read More

Clin Nutr ESPEN 2022 Jun 31;49:425-435. Epub 2022 Mar 31.

Center for Treatment Comparison and Integrative Analysis (CTCIA), Division of Rheumatology, Tufts Medical Center, Boston, MA, USA.

Background: Low-grade chronic inflammation (LGCI) is a strong and independent risk factor for many chronic diseases, like cardiovascular, musculoskeletal, metabolic, and neurological conditions. Dietary intervention studies have reported evidence for the role of plant-derived flavonoids in modulation of LGCI. This research explores the efficacy of Fruit/Berry/Vegetable (FBV) juice powder on LGCI. Read More

Clin Nutr ESPEN 2022 Jun 23;49:417-424. Epub 2022 Mar 23.

Department of Gastroenterological Surgery, Himeji Medical Center, 68 Honmachi, Himeji City, Hyogo, 670-8520, Japan.

Background & Aims: Malnutrition and inflammation adversely affect the prognosis of patients with cancer. The Geriatric Nutritional Risk Index (GNRI) and systemic inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), lymphocyte-to-C reactive protein ratio (LCR), and C-reactive protein-to-albumin ratio (CAR), predict survival in colorectal cancer (CRC) patients. The present study aimed to examine the association of these two factors with CRC survival. Read More

Clin Nutr ESPEN 2022 Jun 31;49:402-410. Epub 2022 Mar 31.

Division of Adult Neurology, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Institute for Neurosciences, St. Luke's Medical Center, Quezon City & Global City, Philippines. Electronic address:

Background And Aims: To explore the association between body mass index (BMI) and adverse outcomes in a large cohort of patients with coronavirus disease 2019 (COVID-19).

Methods: This is a secondary analysis of a 37-site, nationwide, multicenter, retrospective cohort study that investigated the clinical and neurological outcomes of adult patients with confirmed COVID-19 admitted from February to December 15, 2020.

Results: We analyzed 4,463 patients with BMI and outcome data. Read More

Clin Nutr ESPEN 2022 Jun 26;49:378-384. Epub 2022 Mar 26.

Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology, Chulalongkorn University, Bangkok, Thailand; Division of Gastroenterology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross, Bangkok, Thailand. Electronic address:

Background: Late complications associated with percutaneous endoscopic gastrostomy (PEG) tube in patients are common occurrences. We aimed to identify risk factors associated with PEG-related late complications.

Methods: Patients who underwent PEG exchange were retrospectively collected from electronic medical records between January 2015 and November 2020. Read More

Clin Nutr ESPEN 2022 Jun 23;49:365-371. Epub 2022 Mar 23.

Department of Kinesiology, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.

Background & Aims: Excessive adiposity in pregnancy is associated with an altered cardiometabolic profile and adverse maternal and offspring outcomes. Pre-pregnancy body mass index (pBMI) is a proxy measure for adiposity that is most often used in clinical settings; however, it may not identify at-risk pregnancies caused by adiposity-related cardiometabolic dysfunction. The challenge is that validated direct adiposity measures are limited due to the dynamic nature of pregnancy. Read More

Clin Nutr ESPEN 2022 Jun 23;49:357-364. Epub 2022 Mar 23.

Hacettepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkey.

Objective: This study aimed to investigate the serum irisin levels and diet quality of newly-diagnosed type 2 diabetes mellitus (T2DM) patients in comparison with healthy controls and to identify the correlations between serum irisin levels with diet quality, anthropometric measurements and biochemical parameters.

Subjects/methods: This case-control study was conducted with 38 newly-diagnosed T2DM patients and 38 healthy control individuals. Diet quality was calculated from the semi-quantitative food frequency questionnaire by using the Healthy Eating Index (HEI) 2015. Read More

Clin Nutr ESPEN 2022 Jun 24;49:348-356. Epub 2022 Mar 24.

Postgraduate Program in Health and Nutrition, School of Nutrition, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil; Research and Study Group on Nutrition and Public Health (GPENSC), Federal University of Ouro Preto, Brazil; Department of Clinical and Social Nutrition, School of Nutrition, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil. Electronic address:

Background And Aims: Consumption of ultra-processed foods is negatively associated with health outcomes, however, the contribution to sleep quality is limited. Therefore, the objective of this study was to evaluate the association between food intake by frequency and degree of processing and sleep quality in adults during the covid-19 pandemic.

Methods: Population-based survey of adults from October to December 2020 in the Iron Quadrangle region, Brazil. Read More

Clin Nutr ESPEN 2022 Jun 4;49:341-347. Epub 2022 Apr 4.

Laboratory of Investigation of Chronic Diseases, Department of Physiological Sciences, Federal University of Santa Catarina, Florianópolis, 88040-900, SC, Brazil; Graduate Program in Nutrition, Health Sciences Centre, Federal University of Santa Catarina, Florianópolis, 88040-900, SC, Brazil. Electronic address:

Background & Aims: Diabetes mellitus (DM) and cardiovascular disease (CVD) are among the biggest causes of death and health expenses worldwide. A higher dietary acid load (DAL) is associated with chronic low-grade metabolic acidosis, and may increase the risk of insulin resistance (IR), DM, hypertension, and CVD mortality. However, the association between DAL and IR still lacks population-based studies to confirm laboratory findings. Read More

Clin Nutr ESPEN 2022 Jun 31;49:289-294. Epub 2022 Mar 31.

Division of Pediatric Gastroenterology and Nutrition, McGill University Health Center, Canada. Electronic address:

Background: The SMOFlipid is a composite emulsion that has showed benefits, but limited data is available on children receiving prolonged parenteral nutrition (PN). This study aimed to compare conjugated bilirubin (CB) levels at the end of ILE administration in this population.

Methods: Medical charts of all infants treated with Intralipid (Jan 2012-Sep 2013) or SMOFlipid (Oct 2013-Dec 2016) were reviewed. Read More

Clin Nutr ESPEN 2022 Jun 9;49:256-263. Epub 2022 Apr 9.

Department of Pharmacy, Kobe City Medical Center General Hospital, 2-1-1, Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Background And Aims: Despite reports on the impact of vitamin D status on coronavirus disease 2019 (COVID-19) severity, the association between low vitamin D status and severe COVID-19 remains unclear. Moreover, researchers have not determined the aforementioned association in Japanese patients. This study aimed to investigate the association between 25-hydroxyvitamin D [25(OH)D] levels and COVID-19 severity in Japanese patients. Read More

Clin Nutr ESPEN 2022 Jun 28;49:191-196. Epub 2022 Apr 28.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: COVID-19 is an infectious disease which caused a pandemic with many diseases and fatalities. This new variant of coronavirus called SARS-CoV-2 and is primarily characterized by respiratory symptoms. There are some data indicating that LDL-cholesterol (LDL-C) as well as HDL-cholesterol (HDL-C) levels are inversely correlated to disease severity and could act as a predictor for disease progression and unfavorable prognosis. Read More

Clin Nutr ESPEN 2022 Jun 15;49:181-186. Epub 2022 Feb 15.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address:

Background & Aims: Despite controversies, no study has systematically summarized findings from earlier studies on the effect of berberine (BBR)-silymarin on liver enzymes. Therefore, the current systematic review and meta-analysis aimed to investigate the effect of berberis aristate and Silybum marianum on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in adults.

Methods: Relevant studies, published up to June 2021, were searched through PubMed/Medline, Scopus, ISI Web of Science, EMBASE and Google Scholar. Read More

Clin Nutr ESPEN 2022 Jun 14;49:172-180. Epub 2022 Mar 14.

Department of Surgical Oncology, Graduate School of Medicine, Gifu University, Gifu, 501-1194, Japan. Electronic address:

Background & Aims: During chemo- or radiotherapy, oral mucositis is associated with severely affected nutrition, prolonged hospital stays, increased risk of infections, death, hindered cancer treatment, and compromised patient prognosis. Although oral mucositis management is critical, no preventive methods have been firmly established. Nutritional therapy with the oral amino acid-rich elemental diet (ED) Elental® may prevent body composition changes and oral mucositis as dose-limiting toxicities of cancer therapy. Read More

Clin Nutr ESPEN 2022 Jun 12;49:163-171. Epub 2022 Mar 12.

HU University of Applied Sciences, Research Group Innovations in Preventive Health Care, Heidelberglaan 7, 2584 CS Utrecht, the Netherlands. Electronic address:

Background & Aim: Malnutrition adversely influences a broad range of physical and psychological symptoms. Although polypharmacy is often mentioned to be associated with malnutrition, especially in older people it is unclear to what extent. The aim of this systematic review was to investigate the extent of the association between polypharmacy and malnutrition in older people. Read More

Clin Nutr ESPEN 2022 Jun 30;49:154-162. Epub 2022 Mar 30.

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address:

Background: Some studies conducted on soy isoflavones and soy protein reflected that leptin can be reduced by soy isoflavones or soy protein. The aim of present study is to assess the effect of soy isoflavones plus soy protein on serum concentration of leptin among adults.

Methods: To find randomized clinical trails (RCTs) assessing the effect of soy isoflavones containing soy protein on serum concentration of leptin in participants with age ≥18 years old, databases including PubMed, Scopus, ISI Web of Science, Cochrane and ClinicalTrials. Read More

Clin Nutr ESPEN 2022 Jun 31;49:138-153. Epub 2022 Mar 31.

Department of Nutrition, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gera, Brazil. Electronic address:

Background & Aims: The purpose of this systematic review was to analyze the effects of lifestyle interventions on long-term weight maintenance of weight loss. In addition, we seek to address which period is most susceptible to weight regain; and what is the time required for following-up weight maintenance after the intervention.

Methods: Articles published up to August 2020 were identified using the Medline (PubMed), Embase, Web of Science, CENTRAL and Scopus. Read More

Clin Nutr ESPEN 2022 Jun 6;49:129-137. Epub 2022 Apr 6.

HMV, R. Ramiro Barcelos, 910, 91787070, Porto Alegre, RS, Brazil; National Institute of Science and Technology for Health Technology Assessment (IATS), Brazil. Electronic address:

Background: Heart failure (HF) is a growing problem for healthcare systems worldwide. Sodium and fluid restriction are non-pharmacological treatments recommended for patients with HF by several guidelines over the years, even without consensus.

Objective: To evaluate the effects of sodium and fluid restriction in patients with HF. Read More

Clin Nutr ESPEN 2022 Jun 14;49:121-128. Epub 2022 Apr 14.

Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background & Aims: Recent trial studies have found that conjugated linoleic acid (CLA) supplementation beneficially reduces oxidative stress markers but, there is no definitive consensus on this context. The present systematic review and meta-analysis aimed to investigate the effect of CLA supplementation on oxidative stress parameters.

Methods: We searched PubMed, Web of Science, Scopus, Cochrane Library, and Google Scholar databases until September 2021 to identify randomized controlled trials (RCTs) assessing CLA supplementation effects on oxidative markers including malondialdehyde (MDA), 8-isoprostanesF2α (8-iso-PGF2α), and glutathione peroxidase (GPx). Read More