82 results match your criteria Amyloidosis Nodular Localized Cutaneous


Basal Cell Carcinoma Associated with Secondary Localized Cutaneous Amyloid Deposits: Case Report and Review.

Authors:
Philip R Cohen

Cureus 2019 Jan 14;11(1):e3879. Epub 2019 Jan 14.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Amyloid deposition has been observed in tissue specimens of basal cell carcinomas. A 68-year-old man with a nodular basal cell carcinoma on his left arm near the elbow is described; microscopic evaluation of the biopsy tissue specimen shows not only nodular aggregates and strands of atypical basaloid tumor cells but also marked deposition of amorphous amyloid material in the stroma between the aggregates of basal cell carcinoma. Including the man in this report, there are additional individual descriptions of patients whose basal cell carcinomas have amyloid deposits in the adjacent stroma or within the tumor aggregates or both. Read More

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http://dx.doi.org/10.7759/cureus.3879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420332PMC
January 2019
6 Reads

Cutaneous features and diagnosis of primary Sjögren syndrome: An update and review.

J Am Acad Dermatol 2018 Oct 19;79(4):736-745. Epub 2018 May 19.

Department of Dermatology, University of Connecticut, Farmington, Connecticut. Electronic address:

Sjögren syndrome (SS) is an autoimmune connective tissue disorder (CTD) that principally affects the lacrimal and salivary glands. Although SS is 1 of the 3 most common autoimmune CTDs alongside systemic lupus erythematosus and progressive systemic sclerosis, it is the least researched CTD overall. SS poses a particular diagnostic challenge because it shares multiple clinical and immunologic features with other CTDs. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.05.021DOI Listing
October 2018
6 Reads

An unusual presentation of primary cutaneous amyloidosis.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology and STD, Lady Hardinge Medical College. New Delhi, India.

Primary localized cutaneous amyloidosis refers to a group of disorders characterized by deposition of amyloid in the dermis without any systemic involvement. It comprises the following clinical types: macular, lichenoid, nodular, and biphasic. There are also rare variants such as amyloidosis cutis dyscromica and poikiloderma-like cutaneous amyloidosis. Read More

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August 2017
16 Reads

Dystrophic Calcification in a Patient with Primary Localized Cutaneous Nodular Amyloidosis: An Uncommon Ultrasound Finding.

Acta Derm Venereol 2018 01;98(1):144-145

Dermatology Department, Hospital de la Santa Creu i Sant Pau, Carrer de Sant Quintí, 89, ES-08026 Barcelona, Spain.

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http://www.medicaljournals.se/acta/content/abstract/10.2340/
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http://dx.doi.org/10.2340/00015555-2790DOI Listing
January 2018
11 Reads

Cutaneous and Mucosal Manifestations of Sjögren's Syndrome.

Clin Rev Allergy Immunol 2017 Dec;53(3):357-370

Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Via A. Manzoni 56, 20089 Rozzano, Milan, Italy.

Sjögren's syndrome is currently considered an "autoimmune epithelitis," as exocrine glands, especially salivary and lacrimal, are progressively destructed by an immune-mediated process associated with specific serum autoantibodies and local lymphocyte infiltrate. Xerostomia remains a key complain in patients with Sjögren's syndrome but should be evaluated also for other causes such as xerogenic medications, followed by radiation and chemotherapy for head and neck cancers, hormone disorders, infections, or other connective tissue diseases. Further, xerophtalmia (also known as dry eye) frequently associated with keratoconjunctivitis sicca cumulatively affects approximately 10-30% of the general population with increasing incidence with age and is more frequently secondary to non-autoimmune diseases. Read More

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http://dx.doi.org/10.1007/s12016-017-8639-yDOI Listing
December 2017
21 Reads

Nodular cutaneous amyloidoma of the extremity secondary to chronic granulomatous inflammation in setting of sarcoidosis.

J Cutan Pathol 2017 Sep 19;44(9):801-804. Epub 2017 Jul 19.

Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida.

Soft tissue amyloidoma is a rare condition that presents primarily in the abdomen and/or mediastinum and more uncommonly on the extremities. Soft tissue amyloidomas on the extremities have been associated with chronic inflammation, particularly when accompanied by AA-type amyloid deposition as seen in local trauma, surgery, hypertension and diabetes. To our knowledge, this is the first reported case of nodular cutaneous amyloidoma in the setting of systemic and cutaneous sarcoidosis. Read More

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http://dx.doi.org/10.1111/cup.12988DOI Listing
September 2017
38 Reads

Multiple Interdigital Nodular Amyloidosis of the Toe: A Unique Presentation of Localized Cutaneous Amyloidosis.

Ann Dermatol 2017 Jun 11;29(3):349-351. Epub 2017 May 11.

Department of Dermatology, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea.

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http://dx.doi.org/10.5021/ad.2017.29.3.349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438946PMC
June 2017
48 Reads

Three cases of localized cutaneous nodular amyloidosis in patients with limited systemic sclerosis and a brief literature review.

Int J Womens Dermatol 2017 Jun 11;3(2):91-95. Epub 2017 Jan 11.

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, IA.

Localized cutaneous nodular amyloidosis (LCNA) is the rarest form of localized cutaneous amyloidosis. In patients with LCNA, local plasma cells secrete immunoglobulin light chains called amyloid L via an unknown mechanism. LCNA has been associated with autoimmune connective tissue diseases such as most commonly Sjögren syndrome. Read More

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http://dx.doi.org/10.1016/j.ijwd.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440445PMC
June 2017
9 Reads

Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review.

Am J Clin Dermatol 2017 Oct;18(5):629-642

Department of Dermatology, University Hospital Jena, Erfurter Straße 35, Jena, 07743, Germany.

Background: Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposition of heterogenic amyloid proteins in the skin without systemic involvement. Lichen amyloidosis, macular amyloidosis, and (primary localized cutaneous) nodular amyloidosis are different subtypes of PLCA.

Objective: The aim of this study was to review the current reported treatment options for PLCA. Read More

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http://dx.doi.org/10.1007/s40257-017-0278-9DOI Listing
October 2017
26 Reads

Nodular cutaneous amyloidosis effectively treated with intralesional methotrexate.

JAAD Case Rep 2016 Sep 29;2(5):373-376. Epub 2016 Sep 29.

Mid North Coast Area Health Service, Sydney.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045568PMC
http://dx.doi.org/10.1016/j.jdcr.2016.04.006DOI Listing
September 2016
4 Reads

Nodular Cutaneous Amyloidosis at the Temple.

Case Rep Dermatol 2016 May-Aug;8(2):193-6. Epub 2016 Jul 12.

Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.

A 52-year-old woman presented with a large partially yellow and erythematous tumor on her right temple. She reported that it had grown over the last 4 years. Regional lymph nodes were impalpable. Read More

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http://dx.doi.org/10.1159/000447234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965534PMC
August 2016
13 Reads

Nodular Cutaneous Amyloidosis Resembling a Giant Tumor.

Case Rep Dermatol 2016 Jan-Apr;8(1):22-5. Epub 2016 Feb 3.

Department of Dermatology, University Medical Center Regensburg, Germany.

A 79-year-old man presented with a large tumor on the left side of his head, which had grown over 5 years. Regional lymph nodes were impalpable and computed tomography revealed no signs of bone infiltration. Histology showed that the entire dermis was filled with amorphous eosinophilic material. Read More

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http://dx.doi.org/10.1159/000443950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899645PMC
June 2016
13 Reads

[Primary localized cutaneous nodular amyloidosis: A diagnostic and therapeutic challenge].

Ann Dermatol Venereol 2016 Feb 24;143(2):134-8. Epub 2015 Dec 24.

Service de dermatologie, hôpital Saint-André, CHU de Bordeaux, rue Jean-Burguet, 33076 Bordeaux, France. Electronic address:

Background: Nodular primary localized cutaneous amyloidosis (PLCA) is a rare subtype of localized cutaneous amyloidosis in which amyloid protein is derived from immunoglobulin light chains. Follow-up for progression to systemic amyloidosis or autoimmune disease is mandatory. No consensus exists regarding treatment. Read More

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http://dx.doi.org/10.1016/j.annder.2015.10.596DOI Listing
February 2016
21 Reads

Nodular amyloidosis derived from keratinocytes: an unusual type of primary localized cutaneous nodular amyloidosis.

Am J Dermatopathol 2015 Nov;37(11):e129-33

Departments of *Pathology, and †Orthopedics, University of Massachusetts Medical School, Worcester, MA.

Primary, localized cutaneous amyloidosis includes macular, lichen, and nodular (tumefactive) types in which the amyloid deposits are limited to the dermis without systemic involvement. The material in lichen and macular amyloidosis is derived from epidermal keratinocytes [keratinocyte-derived amyloid (AK)], whereas that in nodular amyloidosis is derived from immunoglobulin light-chains amyloid (AL). Primary, localized cutaneous nodular amyloidosis (PLCNA) is a form of primary, localized cutaneous amyloidosis that has been associated with a risk of progression to systemic amyloidosis. Read More

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http://pdfs.journals.lww.com/amjdermatopathology/2015/11000/
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/DAD.0000000000000307DOI Listing
November 2015
15 Reads

Primary localized cutaneous nodular amyloidosis of the thighs.

Cutis 2015 Jun;95(6):E24-7

Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, 400038 China.

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare form of cutaneous amyloidosis. We report the case of a 65-year-old woman with multiple asymptomatic discrete nodules and atrophic plaques on the thighs of 4 years' duration that had increased in number and size. Results of extensive clinical, histologic, and laboratory evaluation showed no evidence of systemic amyloidosis or myeloma. Read More

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June 2015
17 Reads

Primary localized cutaneous nodular amyloidosis with bullous lesions.

Indian J Dermatol Venereol Leprol 2015 Jul-Aug;81(4):400-2

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.4103/0378-6323.157459DOI Listing
March 2016
37 Reads

Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations.

Indian J Dermatol 2015 Jan-Feb;60(1):105

Department of Pathology, J N Medical College, Belgaum, Karnataka, India.

A 55-year-old man presented with multiple, itchy papules and macules on the trunk and extremities. Histopathologic examination of biopsy specimens taken from three different lesions showed a subepidermal blister with amyloid deposits in the dermal papillae. No systemic disease or involvement of other organs was detected. Read More

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http://dx.doi.org/10.4103/0019-5154.147868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318037PMC
February 2015
4 Reads

Immunohistochemical study of immunoglobulin light chains and inflammatory cells in a patient with localized primary cutaneous nodular amyloidosis.

J Eur Acad Dermatol Venereol 2016 Mar 16;30(3):469-70. Epub 2014 Nov 16.

Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.

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http://dx.doi.org/10.1111/jdv.12849DOI Listing
March 2016
2 Reads

An alternative treatment model: the combination therapy of narrow band ultraviolet B phototherapy and tacrolimus ointment 0.1% in biphasic amyloidosis.

J Pak Med Assoc 2014 May;64(5):579-82

Primary localized cutaneous amyloidosis (PLCA) is caused by the extracellular deposition of amyloid material in the skin without other cutaneous or systemic organ involvement. PCLA is classified into lichen, macular,and nodular amyloidosis. Macular amyloidosis and lichen amyloidosis are named as biphasic amyloidosis when they are concurrently seen in a patient. Read More

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May 2014
23 Reads

Nodular primary localized cutaneous amyloidosis in a patient with pulmonary sarcoidosis.

Indian J Dermatol 2014 May;59(3):307-8

Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. E-mail:

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http://dx.doi.org/10.4103/0019-5154.131430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037964PMC
May 2014
7 Reads

Nodular localized primary cutaneous amyloidosis: a bullous variant.

Clin Exp Dermatol 2014 Apr;39(3):344-7

Division of Dermatopathology, Department of Dermatology, University of Connecticut Health Center, Farmington, CT, USA.

Primary cutaneous amyloidosis describes a group of disorders in which amyloid is deposited in the skin without evidence of systemic involvement. Nodular localized primary cutaneous amyloidosis (NLPCA) is a rare form of these skin-restricted amyloidoses. We present an unusual case of NLPCA in a 51-year-old man, who had clinical and histopathological evidence of subepidermal bullous formation, a unique feature in NLPCA. Read More

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http://dx.doi.org/10.1111/ced.12305DOI Listing
April 2014
4 Reads

Primary localized cutaneous nodular amyloidosis of the feet: a case report and review of the literature.

Cutis 2014 Feb;93(2):89-94

59 MDSP/SG07D, 2200 Bergquist Dr, Ste 1, JBSA-Lackland, TX 78236, USA.

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disorder that manifests as the cutaneous formation of nodules composed of light-chain amyloid. Although the type of amyloid deposit is similar to primary systemic amyloidosis, there seems to be little, if any, crossover between the 2 diseases. Because reports of PLCNA are sparse, there is no established protocol for treating this disease. Read More

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February 2014
7 Reads

Primary localized cutaneous amyloidosis.

Dermatol Online J 2013 Dec 16;19(12):20711. Epub 2013 Dec 16.

New York University School of Medicine.

A 61-year-old man presented for evaluation of a bruise-like lesion of the right knee. He was found to have an ill-defined, light brown patch with focal areas of dark red and brown. The histopathologic diagnosis was consistent with amyloidosis. Read More

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December 2013
14 Reads

Primary cutaneous amyloidosis of the glans penis. Two case reports and a review of the literature.

Br J Dermatol 2014 Mar;170(3):730-4

Faculty and Division of Medicine, Department of Dermatology, Chelsea & Westminster Hospital, 369 Fulham Road, London, SW10 9NH, U.K.

Background: Primary cutaneous amyloidosis of the penis is a rare entity.

Objectives: We describe two cases of primary penile cutaneous amyloidosis presenting as localized lesions on the penis and not associated with systemic amyloidosis.

Methods: A comprehensive literature review of all published cases. Read More

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http://doi.wiley.com/10.1111/bjd.12682
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http://dx.doi.org/10.1111/bjd.12682DOI Listing
March 2014
4 Reads

The diagnosis: primary localized cutaneous nodular amyloidosis.

Cutis 2013 Jun;91(6):271, 283-4

Roger Williams Medical Center, Providence, RI 02908, USA.

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June 2013
8 Reads

Nodular localized cutaneous amyloidosis in an immunosuppressed patient.

Int J Dermatol 2015 Jun 20;54(6):708-9. Epub 2013 Jun 20.

Department of Dermatology, Norfolk and Norwich University Hospital, Norwich, UK.

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http://dx.doi.org/10.1111/ijd.12140DOI Listing
June 2015
5 Reads

Primary localized cutaneous nodular amyloidosis successfully treated with cyclophosphamide.

Australas J Dermatol 2013 Feb 31;54(1):e12-5. Epub 2011 May 31.

Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia.

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare subtype of localized cutaneous amyloidosis and can be associated with various connective tissue disorders. It can be difficult to treat and past therapies include surgical excision, dermabrasion, electrodessication and curettage, cryotherapy and laser therapy. We present a case of a middle-aged woman with PLCNA associated with CREST (calcinosis, Raynaud phenomenon, oesophageal motility disorders, sclerodactyly and telangiectasia) syndrome and Sjögren's syndrome responding to cyclophosphamide with no new amyloid deposits and resolution of skin ulceration after many years of resistance to drug therapy. Read More

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http://dx.doi.org/10.1111/j.1440-0960.2011.00770.xDOI Listing
February 2013
6 Reads
1 Citation
0.982 Impact Factor

Nodular pulmonary amyloidosis is characterized by localized immunoglobulin deposition and is frequently associated with an indolent B-cell lymphoproliferative disorder.

Am J Surg Pathol 2013 Mar;37(3):406-12

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.

Nodular pulmonary amyloidosis, a rare localized form of amyloidosis, has been associated with immunoglobulin light chains (AL type) and variably with low-grade lymphoma. The clinicopathologic features of 18 cases were investigated; 5 of 14 had autoimmune disease. In 14 cases monotypic plasma cells could be demonstrated by immunohistochemistry. Read More

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http://pdfs.journals.lww.com/ajsp/2013/03000/Nodular_Pulmona
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0b013e318272fe19DOI Listing
March 2013
10 Reads

Effective treatment of nodular amyloidosis with carbon dioxide laser.

J Cutan Med Surg 2012 Sep-Oct;16(5):372-4

Department of Dermatology, Medical University of Lodz, Lodz, Poland.

Background: Nodular amyloidosis is a rare form of localized cutaneous amyloidosis that is characterized by nodules located on the extremities, trunk, genitalia, or face. In treatment regimens, many approaches have been described, including carbon dioxide (CO2) laser therapy.

Objective: We present a case of a 60-year-old white male with a 20-year history of disseminated waxy, purpuric, yellowish, and bullous skin lesions on the trunk and extremities. Read More

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http://dx.doi.org/10.1177/120347541201600519DOI Listing
December 2012
6 Reads

Nodular cutaneous amyloidosis.

Skinmed 2011 Sep-Oct;9(5):316-8

Largo Medical Center, Largo, FL, USA.

A 56-year-old white man presented with a lesion on the right shoulder. The lesion developed during a short period and recently became irritated with occasional bleeding and mild pruritus. The patient denied pain. Read More

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December 2011
9 Reads

Primary localized cutaneous nodular amyloidosis following local trauma.

Ann Dermatol 2011 Nov 3;23(4):515-8. Epub 2011 Nov 3.

Department of Dermatology, School of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea.

Primary localized cutaneous nodular amyloidosis (nodular amyloidosis) is a rare and distinct type of amyloidosis, in which amyloid L deposition is limited to the skin and typically manifested as a tumefactive nodule on the acral sites. However, the definite cause of nodular amyloidosis is still unknown. Although it is relatively well known that the amyloid deposits in nodular amyloidosis originate from immunoglobulin light chains secreted by local plasma cells, traumatic injury to the skin has rarely been recognized as a triggering factor of nodular amyloidosis. Read More

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http://dx.doi.org/10.5021/ad.2011.23.4.515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229950PMC
November 2011
45 Reads

Localized primary cutaneous nodular amyloidosis: case report.

An Bras Dermatol 2011 Sep-Oct;86(5):987-90

Fundação Alfredo da Matta, Manaus, AM, Brasil.

Amyloidosis results from deposition of fibrous and insoluble amyloid protein in extracellular spaces of organs and tissues. Amyloid deposition can be localized or systemic and either primary or secondary. We report a case of localized primary cutaneous nodular amyloidosis manifested by papular-nodular, reddish-brown lesions affecting the nasal area, without evidence of systemic involvement. Read More

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October 2012
6 Reads

Primary sjögren syndrome manifested as localized cutaneous nodular amyloidosis.

J Clin Rheumatol 2011 Oct;17(7):368-70

Department of Dermatology, School of Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan.

Localized cutaneous nodular amyloidosis (LCNA) is the rarest type of cutaneous amyloidosis. Typically presenting as waxy nodules on the lower extremities, it demonstrates localized deposition of AL-type amyloid in immunohistologic study and is often associated with focal plasma cell proliferation. Sjögren syndrome, an autoimmune lymphoproliferative disorder, is characterized by keratoconjunctivitis sicca and xerostomia with lymphocytic infiltration of exocrine glands. Read More

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http://dx.doi.org/10.1097/RHU.0b013e31823209baDOI Listing
October 2011
2 Reads

Nodular amyloidosis in a patient with liver cirrhosis.

Dermatol Online J 2011 Jul 15;17(7):10. Epub 2011 Jul 15.

Department of Dermatology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.

A 43-year-old Japanese man with alcoholic liver cirrhosis developed a nodule on the face 1 year prior to presentation. Histopathological examination showed amyloid deposition in the entire dermis, with numerous plasma cells. Nodular primary localized cutaneous amyloidosis is a rare form of amyloidosis, which needs long-term follow-up because of the possibility of the development of systemic amyloidosis. Read More

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July 2011
2 Reads

Nodular localized primary cutaneous amyloidosis and primary marginal zone B-cell lymphoma on the nose: treatment with microscopically controlled surgery.

Int J Dermatol 2011 Apr;50(4):458-61

Department of Dermatology, Venereology and Allergology, Leipzig University Medical Center, Philipp Rosenthalstr, Leipzig, Germany.

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http://dx.doi.org/10.1111/j.1365-4632.2010.04524.xDOI Listing
April 2011
9 Reads

Images in dermatology. A plethora of protein. Primary localized cutaneous nodular amyloidosis.

Am J Med 2010 Oct;123(10):904-6

Department of Dermatology, Sydney Cancer Centre, University of Sydney at Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

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http://dx.doi.org/10.1016/j.amjmed.2010.06.009DOI Listing
October 2010
5 Reads

Amyloid light chain deposition associated with dermatofibroma: serendipity or association?

Am J Dermatopathol 2010 May;32(3):298-300

Department of Pathology, University of South Florida, College of Medicine, Tampa, FL 33612, USA.

Primary cutaneous amyloidosis, also known as nodular amyloidosis, is defined as deposition of amyloid light chain in the skin in the absence of a systemic cause of amyloidosis. Such amyloid is produced by a localized aggregate of clonal plasma cells. In contrast, secondary cutaneous amyloidosis is related to lesions such as squamous cell carcinoma, Bowen disease, basal cell carcinoma, and discoid lupus erythematosus, and has been shown in most cases to be derived from keratin epithelial elements. Read More

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http://dx.doi.org/10.1097/DAD.0b013e3181b7fd94DOI Listing
May 2010
11 Reads

[Disseminated nodular primary localized cutaneous amyloidosis].

Actas Dermosifiliogr 2008 Oct;99(8):648-52

Servicio de Dermatología, Hospital Universitario La Paz, Madrid, España.

Amyloid is a proteinaceous material that is deposited in the tissues in a large variety of clinical contexts; in the skin it can be found with or without concomitant systemic disease. Primary localized cutaneous amyloidosis encompasses those amyloidoses restricted to the skin without involvement of other systems. The most common forms within this group are macular and lichen amyloidosis. Read More

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October 2008
29 Reads

Primary localized cutaneous nodular amyloidosis and CREST syndrome: a case report and review of the literature.

Cutis 2008 Jul;82(1):55-9

Department of Internal Medicine, Harvard Medical Faculty Physicians, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Primary localized cutaneous nodular amyloidosis (PLCNA) is a form of primary localized cutaneous amyloidosis (PLCA) that presents as yellowish waxy nodules on the extremities, face, trunk, or genitalia. We report the case of a patient with PLCNA and CREST (calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia) syndrome. A diagnosis of her extensive PLCNA was made after biopsy specimens from the bilateral shins stained positive for amyloid extending from the superficial papillary dermis to the subcutis. Read More

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July 2008
4 Reads

Sjögren's syndrome and localized nodular cutaneous amyloidosis: coincidence or a distinct clinical entity?

Arthritis Rheum 2008 Jul;58(7):1992-9

University of Groningen, Groningen, The Netherlands.

Objective: To report 8 patients with Sjögren's syndrome (SS) and localized nodular cutaneous amyloidosis and to examine serologic and immunohistologic findings that may link the 2 diseases.

Methods: The databases for 3 amyloidosis centers were searched for patients with localized nodular cutaneous amyloidosis and SS. Eight patients with this combination were identified, and clinical, serologic, and histologic parameters were retrospectively evaluated. Read More

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http://dx.doi.org/10.1002/art.23617DOI Listing
July 2008
15 Reads

Primary localized nodular cutaneous amyloidosis in a male neutered Golden Retriever.

Authors:
M Woldemeskel

Dtsch Tierarztl Wochenschr 2007 Dec;114(12):473-5

University of Georgia, College of Veterinary Medicine, Department of Pathology, Tifton 31793, USA.

Cutaneous amyloidosis occurs as primary localized form or secondary to systemic amyloidosis. In dogs, cutaneous amyloidosis is reported in association with localized plasma cell proliferation or cutaneous extramedullary plasmacytoma. Primary cutaneous amyloidosis is a very rare condition in dogs. Read More

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December 2007
4 Reads

Nodular primary localized cutaneous amyloidosis after trauma: a case report and discussion of the rate of progression to systemic amyloidosis.

J Am Acad Dermatol 2007 Aug;57(2 Suppl):S26-9

Division of Dermatology, University of Louisville, Kentucky, USA.

Nodular primary localized cutaneous amyloidosis (NPLCA) has been associated with progression to systemic amyloidosis. The reported estimate of 50% progression to systemic amyloidosis has come under scrutiny as recent studies have suggested a significantly lower rate. Still, it is essential to consider systemic amyloidosis after making the diagnosis of NPLCA and to follow up patients longitudinally for possible progression to systemic disease. Read More

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http://dx.doi.org/10.1016/j.jaad.2006.12.014DOI Listing
August 2007
6 Reads

Papules and plaques on the nose. Nodular localized primary cutaneous amyloidosis.

Arch Dermatol 2007 Apr;143(4):535-40

Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1001/archderm.143.4.535-dDOI Listing
April 2007
4 Reads

Extensive nodular cutaneous amyloidosis: an unusual presentation.

J Eur Acad Dermatol Venereol 2005 Jul;19(4):481-3

Dermatology Unit, Hospital do Servidor Público Estadual de São Paulo, Brazil.

Amyloidosis is characterized by the deposition of a group of unrelated proteins leading to changes in tissue architecture and function. The nodular variant is the rarest form of the cutaneous amyloidoses. We report a patient with localized nodular amyloidosis without systemic amyloid involvement or paraproteinaemia after 6 years of follow-up. Read More

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http://dx.doi.org/10.1111/j.1468-3083.2004.01182.xDOI Listing
July 2005
4 Reads

Primary localized cutaneous nodular amyloidosis in a patient with Sjögren's syndrome: a review of the literature.

J Dermatol 2005 Feb;32(2):120-3

Department of Dermatology, School of Medicine, Chiba University, Japan.

We report a 53-year-old Japanese woman with multiple, red, and elastic soft nodules on the left waist, left thigh, and right lower leg. She had had polyclonal hyperglobulinemia for one year, rheumatoid arthritis for 13 years, and Sjögren's syndrome (SjS) for 18 years. Histochemical examination of the nodule on the left thigh revealed a deposition of amyloid by Congo red staining. Read More

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February 2005
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Nodular primary localized cutaneous amyloidosis.

J Eur Acad Dermatol Venereol 2004 Mar;18(2):224-6

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March 2004
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