Search our Database of Scientific Publications and Authors

I’m looking for a

    74 results match your criteria Amyloidosis Nodular Localized Cutaneous

    1 OF 2

    Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review.
    Am J Clin Dermatol 2017 Mar 24. Epub 2017 Mar 24.
    Department of Dermatology, University Hospital Jena, Erfurter Straße 35, Jena, 07743, Germany.
    Background: Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposition of heterogenic amyloid proteins in the skin without systemic involvement. Lichen amyloidosis, macular amyloidosis, and (primary localized cutaneous) nodular amyloidosis are different subtypes of PLCA.

    Objective: The aim of this study was to review the current reported treatment options for PLCA. Read More

    Nodular Cutaneous Amyloidosis at the Temple.
    Case Rep Dermatol 2016 May-Aug;8(2):193-6. Epub 2016 Jul 12.
    Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.
    A 52-year-old woman presented with a large partially yellow and erythematous tumor on her right temple. She reported that it had grown over the last 4 years. Regional lymph nodes were impalpable. Read More

    Nodular Cutaneous Amyloidosis Resembling a Giant Tumor.
    Case Rep Dermatol 2016 Jan-Apr;8(1):22-5. Epub 2016 Feb 3.
    Department of Dermatology, University Medical Center Regensburg, Germany.
    A 79-year-old man presented with a large tumor on the left side of his head, which had grown over 5 years. Regional lymph nodes were impalpable and computed tomography revealed no signs of bone infiltration. Histology showed that the entire dermis was filled with amorphous eosinophilic material. Read More

    [Primary localized cutaneous nodular amyloidosis: A diagnostic and therapeutic challenge].
    Ann Dermatol Venereol 2016 Feb 24;143(2):134-8. Epub 2015 Dec 24.
    Service de dermatologie, hôpital Saint-André, CHU de Bordeaux, rue Jean-Burguet, 33076 Bordeaux, France. Electronic address:
    Background: Nodular primary localized cutaneous amyloidosis (PLCA) is a rare subtype of localized cutaneous amyloidosis in which amyloid protein is derived from immunoglobulin light chains. Follow-up for progression to systemic amyloidosis or autoimmune disease is mandatory. No consensus exists regarding treatment. Read More

    Nodular amyloidosis derived from keratinocytes: an unusual type of primary localized cutaneous nodular amyloidosis.
    Am J Dermatopathol 2015 Nov;37(11):e129-33
    Departments of *Pathology, and †Orthopedics, University of Massachusetts Medical School, Worcester, MA.
    Primary, localized cutaneous amyloidosis includes macular, lichen, and nodular (tumefactive) types in which the amyloid deposits are limited to the dermis without systemic involvement. The material in lichen and macular amyloidosis is derived from epidermal keratinocytes [keratinocyte-derived amyloid (AK)], whereas that in nodular amyloidosis is derived from immunoglobulin light-chains amyloid (AL). Primary, localized cutaneous nodular amyloidosis (PLCNA) is a form of primary, localized cutaneous amyloidosis that has been associated with a risk of progression to systemic amyloidosis. Read More

    Primary localized cutaneous nodular amyloidosis of the thighs.
    Cutis 2015 Jun;95(6):E24-7
    Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, 400038 China.
    Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare form of cutaneous amyloidosis. We report the case of a 65-year-old woman with multiple asymptomatic discrete nodules and atrophic plaques on the thighs of 4 years' duration that had increased in number and size. Results of extensive clinical, histologic, and laboratory evaluation showed no evidence of systemic amyloidosis or myeloma. Read More

    Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations.
    Indian J Dermatol 2015 Jan-Feb;60(1):105
    Department of Pathology, J N Medical College, Belgaum, Karnataka, India.
    A 55-year-old man presented with multiple, itchy papules and macules on the trunk and extremities. Histopathologic examination of biopsy specimens taken from three different lesions showed a subepidermal blister with amyloid deposits in the dermal papillae. No systemic disease or involvement of other organs was detected. Read More

    An alternative treatment model: the combination therapy of narrow band ultraviolet B phototherapy and tacrolimus ointment 0.1% in biphasic amyloidosis.
    J Pak Med Assoc 2014 May;64(5):579-82
    Primary localized cutaneous amyloidosis (PLCA) is caused by the extracellular deposition of amyloid material in the skin without other cutaneous or systemic organ involvement. PCLA is classified into lichen, macular,and nodular amyloidosis. Macular amyloidosis and lichen amyloidosis are named as biphasic amyloidosis when they are concurrently seen in a patient. Read More

    Nodular localized primary cutaneous amyloidosis: a bullous variant.
    Clin Exp Dermatol 2014 Apr;39(3):344-7
    Division of Dermatopathology, Department of Dermatology, University of Connecticut Health Center, Farmington, CT, USA.
    Primary cutaneous amyloidosis describes a group of disorders in which amyloid is deposited in the skin without evidence of systemic involvement. Nodular localized primary cutaneous amyloidosis (NLPCA) is a rare form of these skin-restricted amyloidoses. We present an unusual case of NLPCA in a 51-year-old man, who had clinical and histopathological evidence of subepidermal bullous formation, a unique feature in NLPCA. Read More

    Primary localized cutaneous nodular amyloidosis of the feet: a case report and review of the literature.
    Cutis 2014 Feb;93(2):89-94
    59 MDSP/SG07D, 2200 Bergquist Dr, Ste 1, JBSA-Lackland, TX 78236, USA.
    Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disorder that manifests as the cutaneous formation of nodules composed of light-chain amyloid. Although the type of amyloid deposit is similar to primary systemic amyloidosis, there seems to be little, if any, crossover between the 2 diseases. Because reports of PLCNA are sparse, there is no established protocol for treating this disease. Read More

    Primary localized cutaneous amyloidosis.
    Dermatol Online J 2013 Dec 16;19(12):20711. Epub 2013 Dec 16.
    New York University School of Medicine.
    A 61-year-old man presented for evaluation of a bruise-like lesion of the right knee. He was found to have an ill-defined, light brown patch with focal areas of dark red and brown. The histopathologic diagnosis was consistent with amyloidosis. Read More

    Primary cutaneous amyloidosis of the glans penis. Two case reports and a review of the literature.
    Br J Dermatol 2014 Mar;170(3):730-4
    Faculty and Division of Medicine, Department of Dermatology, Chelsea & Westminster Hospital, 369 Fulham Road, London, SW10 9NH, U.K.
    Background: Primary cutaneous amyloidosis of the penis is a rare entity.

    Objectives: We describe two cases of primary penile cutaneous amyloidosis presenting as localized lesions on the penis and not associated with systemic amyloidosis.

    Methods: A comprehensive literature review of all published cases. Read More

    Primary localized cutaneous nodular amyloidosis successfully treated with cyclophosphamide.
    Australas J Dermatol 2013 Feb 31;54(1):e12-5. Epub 2011 May 31.
    Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia.
    Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare subtype of localized cutaneous amyloidosis and can be associated with various connective tissue disorders. It can be difficult to treat and past therapies include surgical excision, dermabrasion, electrodessication and curettage, cryotherapy and laser therapy. We present a case of a middle-aged woman with PLCNA associated with CREST (calcinosis, Raynaud phenomenon, oesophageal motility disorders, sclerodactyly and telangiectasia) syndrome and Sjögren's syndrome responding to cyclophosphamide with no new amyloid deposits and resolution of skin ulceration after many years of resistance to drug therapy. Read More

    Nodular pulmonary amyloidosis is characterized by localized immunoglobulin deposition and is frequently associated with an indolent B-cell lymphoproliferative disorder.
    Am J Surg Pathol 2013 Mar;37(3):406-12
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
    Nodular pulmonary amyloidosis, a rare localized form of amyloidosis, has been associated with immunoglobulin light chains (AL type) and variably with low-grade lymphoma. The clinicopathologic features of 18 cases were investigated; 5 of 14 had autoimmune disease. In 14 cases monotypic plasma cells could be demonstrated by immunohistochemistry. Read More

    Effective treatment of nodular amyloidosis with carbon dioxide laser.
    J Cutan Med Surg 2012 Sep-Oct;16(5):372-4
    Department of Dermatology, Medical University of Lodz, Lodz, Poland.
    Background: Nodular amyloidosis is a rare form of localized cutaneous amyloidosis that is characterized by nodules located on the extremities, trunk, genitalia, or face. In treatment regimens, many approaches have been described, including carbon dioxide (CO2) laser therapy.

    Objective: We present a case of a 60-year-old white male with a 20-year history of disseminated waxy, purpuric, yellowish, and bullous skin lesions on the trunk and extremities. Read More

    Primary localized cutaneous nodular amyloidosis following local trauma.
    Ann Dermatol 2011 Nov 3;23(4):515-8. Epub 2011 Nov 3.
    Department of Dermatology, School of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea.
    Primary localized cutaneous nodular amyloidosis (nodular amyloidosis) is a rare and distinct type of amyloidosis, in which amyloid L deposition is limited to the skin and typically manifested as a tumefactive nodule on the acral sites. However, the definite cause of nodular amyloidosis is still unknown. Although it is relatively well known that the amyloid deposits in nodular amyloidosis originate from immunoglobulin light chains secreted by local plasma cells, traumatic injury to the skin has rarely been recognized as a triggering factor of nodular amyloidosis. Read More

    Localized primary cutaneous nodular amyloidosis: case report.
    An Bras Dermatol 2011 Sep-Oct;86(5):987-90
    Fundação Alfredo da Matta, Manaus, AM, Brasil.
    Amyloidosis results from deposition of fibrous and insoluble amyloid protein in extracellular spaces of organs and tissues. Amyloid deposition can be localized or systemic and either primary or secondary. We report a case of localized primary cutaneous nodular amyloidosis manifested by papular-nodular, reddish-brown lesions affecting the nasal area, without evidence of systemic involvement. Read More

    Primary sjögren syndrome manifested as localized cutaneous nodular amyloidosis.
    J Clin Rheumatol 2011 Oct;17(7):368-70
    Department of Dermatology, School of Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan.
    Localized cutaneous nodular amyloidosis (LCNA) is the rarest type of cutaneous amyloidosis. Typically presenting as waxy nodules on the lower extremities, it demonstrates localized deposition of AL-type amyloid in immunohistologic study and is often associated with focal plasma cell proliferation. Sjögren syndrome, an autoimmune lymphoproliferative disorder, is characterized by keratoconjunctivitis sicca and xerostomia with lymphocytic infiltration of exocrine glands. Read More

    Nodular amyloidosis in a patient with liver cirrhosis.
    Dermatol Online J 2011 Jul 15;17(7):10. Epub 2011 Jul 15.
    Department of Dermatology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
    A 43-year-old Japanese man with alcoholic liver cirrhosis developed a nodule on the face 1 year prior to presentation. Histopathological examination showed amyloid deposition in the entire dermis, with numerous plasma cells. Nodular primary localized cutaneous amyloidosis is a rare form of amyloidosis, which needs long-term follow-up because of the possibility of the development of systemic amyloidosis. Read More

    Amyloid light chain deposition associated with dermatofibroma: serendipity or association?
    Am J Dermatopathol 2010 May;32(3):298-300
    Department of Pathology, University of South Florida, College of Medicine, Tampa, FL 33612, USA.
    Primary cutaneous amyloidosis, also known as nodular amyloidosis, is defined as deposition of amyloid light chain in the skin in the absence of a systemic cause of amyloidosis. Such amyloid is produced by a localized aggregate of clonal plasma cells. In contrast, secondary cutaneous amyloidosis is related to lesions such as squamous cell carcinoma, Bowen disease, basal cell carcinoma, and discoid lupus erythematosus, and has been shown in most cases to be derived from keratin epithelial elements. Read More

    [Disseminated nodular primary localized cutaneous amyloidosis].
    Actas Dermosifiliogr 2008 Oct;99(8):648-52
    Servicio de Dermatología, Hospital Universitario La Paz, Madrid, España.
    Amyloid is a proteinaceous material that is deposited in the tissues in a large variety of clinical contexts; in the skin it can be found with or without concomitant systemic disease. Primary localized cutaneous amyloidosis encompasses those amyloidoses restricted to the skin without involvement of other systems. The most common forms within this group are macular and lichen amyloidosis. Read More

    Primary localized cutaneous nodular amyloidosis and CREST syndrome: a case report and review of the literature.
    Cutis 2008 Jul;82(1):55-9
    Department of Internal Medicine, Harvard Medical Faculty Physicians, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
    Primary localized cutaneous nodular amyloidosis (PLCNA) is a form of primary localized cutaneous amyloidosis (PLCA) that presents as yellowish waxy nodules on the extremities, face, trunk, or genitalia. We report the case of a patient with PLCNA and CREST (calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia) syndrome. A diagnosis of her extensive PLCNA was made after biopsy specimens from the bilateral shins stained positive for amyloid extending from the superficial papillary dermis to the subcutis. Read More

    Sjögren's syndrome and localized nodular cutaneous amyloidosis: coincidence or a distinct clinical entity?
    Arthritis Rheum 2008 Jul;58(7):1992-9
    University of Groningen, Groningen, The Netherlands.
    Objective: To report 8 patients with Sjögren's syndrome (SS) and localized nodular cutaneous amyloidosis and to examine serologic and immunohistologic findings that may link the 2 diseases.

    Methods: The databases for 3 amyloidosis centers were searched for patients with localized nodular cutaneous amyloidosis and SS. Eight patients with this combination were identified, and clinical, serologic, and histologic parameters were retrospectively evaluated. Read More

    Primary localized nodular cutaneous amyloidosis in a male neutered Golden Retriever.
    Dtsch Tierarztl Wochenschr 2007 Dec;114(12):473-5
    University of Georgia, College of Veterinary Medicine, Department of Pathology, Tifton 31793, USA.
    Cutaneous amyloidosis occurs as primary localized form or secondary to systemic amyloidosis. In dogs, cutaneous amyloidosis is reported in association with localized plasma cell proliferation or cutaneous extramedullary plasmacytoma. Primary cutaneous amyloidosis is a very rare condition in dogs. Read More

    Nodular primary localized cutaneous amyloidosis after trauma: a case report and discussion of the rate of progression to systemic amyloidosis.
    J Am Acad Dermatol 2007 Aug;57(2 Suppl):S26-9
    Division of Dermatology, University of Louisville, Kentucky, USA.
    Nodular primary localized cutaneous amyloidosis (NPLCA) has been associated with progression to systemic amyloidosis. The reported estimate of 50% progression to systemic amyloidosis has come under scrutiny as recent studies have suggested a significantly lower rate. Still, it is essential to consider systemic amyloidosis after making the diagnosis of NPLCA and to follow up patients longitudinally for possible progression to systemic disease. Read More

    Extensive nodular cutaneous amyloidosis: an unusual presentation.
    J Eur Acad Dermatol Venereol 2005 Jul;19(4):481-3
    Dermatology Unit, Hospital do Servidor Público Estadual de São Paulo, Brazil.
    Amyloidosis is characterized by the deposition of a group of unrelated proteins leading to changes in tissue architecture and function. The nodular variant is the rarest form of the cutaneous amyloidoses. We report a patient with localized nodular amyloidosis without systemic amyloid involvement or paraproteinaemia after 6 years of follow-up. Read More

    Primary localized cutaneous nodular amyloidosis in a patient with Sjögren's syndrome: a review of the literature.
    J Dermatol 2005 Feb;32(2):120-3
    Department of Dermatology, School of Medicine, Chiba University, Japan.
    We report a 53-year-old Japanese woman with multiple, red, and elastic soft nodules on the left waist, left thigh, and right lower leg. She had had polyclonal hyperglobulinemia for one year, rheumatoid arthritis for 13 years, and Sjögren's syndrome (SjS) for 18 years. Histochemical examination of the nodule on the left thigh revealed a deposition of amyloid by Congo red staining. Read More

    Cutaneous nodular amyloidosis masquerading as a foot callus.
    J Am Acad Dermatol 2003 Aug;49(2):307-10
    Deparment of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
    We report a unique case of a 69-year-old man who presented with a 1-year history of pink nodules and plaques limited to the anterior plantar surface of the right foot and a 30-year history of a callus on the right heel. Histologic examination findings of both areas showed deposits of amorphous, eosinophilic material and an infiltrate of plasma cells in the dermis. Congo red-stained deposits exhibited apple-green birefringence with polarized light. Read More

    [Two cases of limited cutaneous nodular amyloidosis with primary Sjögren's syndrome].
    Nihon Rinsho Meneki Gakkai Kaishi 2002 Apr;25(2):205-11
    Yokohama City University School of Medicine, First Department of Internal Medicine.
    We described two female patients with primary Sjögren's syndrome associated with localized cutaneous nodular amyloidosis (LCNA), in which amyloid protein was derived from immunoglobulin light chain. Case 1; a 70-year-old female had complained with polyarthralgia, low-grade fever and parotid gland swelling. She was diagnosed as primary Sjögren's syndrome. Read More

    Advanced glycation end product-modified beta2-microglobulin is a component of amyloid fibrils of primary localized cutaneous nodular amyloidosis.
    J Invest Dermatol 2002 Mar;118(3):479-84
    Department of Dermatology, National Defense Medical College, Saitama, Japan.
    Primary localized cutaneous nodular amyloidosis is a rare form of cutaneous amyloidosis. Amyloid fibrils in primary localized cutaneous nodular amyloidosis have been reported to be originated from immunoglobulin light chains. Immunohistochemical studies on the lesional skins of four patients with primary localized cutaneous nodular amyloidosis demonstrated that amyloid deposits of all cases showed a positive reaction with the antibodies for beta2-microglobulin and advanced glycation end products as well as immunoglobulin light chain (kappa or lambda). Read More

    Nodular localized primary cutaneous amyloidosis: a long-term follow-up study.
    Br J Dermatol 2001 Jul;145(1):105-9
    St John's Institute of Dermatology, The Guy's, King's College and St Thomas' Medical and Dental Schools, University of London, UK.
    We present long-term follow-up data on patients with nodular localized primary cutaneous amyloidosis (NLPCA) seen at the St John's Institute of Dermatology between 1968 and 1999. This is the largest clinical follow-up study of this type of amyloid to date. Based on these cases we estimate the rate of progression of NLPCA to systemic amyloidosis to be only 7%, much lower than the 50% rate currently quoted in the literature. Read More

    Nodular amyloidosis: case report and literature review.
    J Cutan Med Surg 2001 Mar-Apr;5(2):101-4. Epub 2001 Mar 2.
    Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
    Background: Amyloidosis refers to a group of depositional diseases that are classified into two main types: systemic and localized. Large nodules of localized cutaneous amyloidosis of the nasal ala and surrounding skin are rare and the treatment is often unsatisfactory.

    Objective: We report a case of rapidly enlarging, localized, nodular cutaneous amyloidosis of the nose and the surrounding skin with a brief review of the current literature regarding treatment of this rare disease. Read More

    Vulvar paraneoplastic amyloidosis with the appearance of a vulvar carcinoma.
    Am J Obstet Gynecol 1999 Apr;180(4):1041-4
    Departments of Gynecology and Obstetrics, Dermatology, and Internal Medicine, Medisch Spectrum Twente, Enschede, The Netherlands.
    Nodular cutaneous amyloidosis of the vulva is a rare phenomenon. We describe a patient with localized nodular lesions on the vulva that mimicked kissing ulcers such as are seen with vulvar carcinoma. These lesions were a result of multiple myeloma with subsequent primary systemic amyloidosis. Read More

    Nodular amyloidosis treated with a pulsed dye laser.
    Dermatol Surg 1999 Feb;25(2):133-5
    Washington Institute of Dermatologic Laser Surgery, Washington, DC, USA.
    Background: Nodular amyloidosis is a rare form of primary localized cutaneous amyloidosis which is characterized by single or multiple nodules located on the extremities, trunk, genitalia, or face.

    Objective: To determine the clinical and histologic response of nodular amyloidosis to pulsed dye laser treatment.

    Methods: Biopsy-proven amyloid nodules were treated with a 585-nm pulsed dye laser (average fluence 5. Read More

    1 OF 2