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Skinmed 2022 30;20(2):141-143. Epub 2022 Apr 30.

Department of Dermatology and Sexually Transmitted Diseases, Lady Hardinge Medical College and Sucheta Kriplani Hospital, Delhi, India.

A 40-year-old male, wrestler since 15 years of age presented with asymptomatic hyperpigmentation over both his both upper extremities for 10 years. There was no history of preceding itching or redness; of using a nylon brush, scrubbers, or sponges during bathing; or of excessive towel rubbing after bathing and applying cosmetics; however, he had been rubbing sand over both arms for 15 years. He had no personal or family history of atopy, diabetes, or thyroid disease. Read More

Ther Deliv 2022 Mar 7. Epub 2022 Mar 7.

Tower Pharma Consulting, Bellakreuzstrasse 21, Berndorf, 2560, Austria.

This Industry Update provides an overview of the some of the key events in the pharmaceutical world in December 2021. In this month Eli Lilly & Co invested heavily in drug discovery with deals with Regor Therapeutics on metabolic diseases, and Foghorn Therapeutics on cancer and other diseases caused by faults in the regulation of chromatin unpacking and repacking. Treatments for Covid-19 also feature heavily with the emergency authorization of molnupiravir and Paxlovid™ in the USA, and BiondVax's collaboration agreement with Max Planck and the University Medical Center, Göttingham on their alpaca-based single-chain antibodies targeting the SARS-CoV-2 spike protein. Read More

Skin Res Technol 2022 Feb 21. Epub 2022 Feb 21.

Department of Dermatology, Third People's Hospital of Hangzhou, Hangzhou, China.

Background: Primary cutaneous amyloidosis (PCA) is apruritic and potentially disfiguring disorder; this disease is usually diagnosed clinically due to its common occurrence. However, for cases with atypical presentations or for those physicians not familiar with PCA, the diagnosis can be a challenge.

Objective: To observe the characteristics of PCA under dermoscopy and reflectance confocal microscopy (RCM) in order to gain experience and reference for clinicians to facilitate diagnosis. Read More

Retina 2022 05;42(5):981-991

Dr. Alejandro Dalma y Asociados, SC Mexico City, Mexico.

Background: Autosomal dominant Müller cell dystrophy is a rare condition we described in 1991. It is characterized by a striking sheen appearance on the retinal surface with progressive retinal changes leading to disorganization and atrophy with a decreased b-wave electroretinograms.

Materials And Methods: We examined 45 members of a 4-generation family. Read More

Dermatol Ther 2022 01 30;35(1):e15213. Epub 2021 Nov 30.

Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Macular amyloidosis (MA) is a common form of cutaneous amyloidosis that manifests as dark spots consisting of brown pigments with a rippled pattern on the skin, and the treatment of this condition is highly challenging. The aim of this study was to compare the efficacy and safety of intralesional injection of tranexamic acid (TXA) and topical application of Kligman combination drug in the treatment of macular amyloidosis. In this double-blind clinical trial, a total of 43 patients, who were diagnosed with MA, were treated with two different methods of intralesional injection of tranexamic acid and topical application of Kligman combination drug. Read More

Medicina (Kaunas) 2021 Sep 27;57(10). Epub 2021 Sep 27.

Department of Dermatology, Institute of Medical Sciences, Medical College, Rzeszow University, 35-310 Rzeszów, Poland.

Primary cutaneous amyloidosis (PCA) is characterized by the extracellular deposition of amyloid in the skin without systemic involvement. It comprises several clinical variants, the most common of which are macular amyloidosis (MA) and lichen amyloidosis (LA). PCA is frequently observed in Asians, while it is considered to be very rare in Caucasians. Read More

Lasers Med Sci 2022 Mar 6;37(2):799-813. Epub 2021 Oct 6.

Faculty of Medicine, Kerman University of Medical Sciences, Haft Bagh Alavi Blvd, Postal Code: 7616913555, Kerman, Iran.

With the investigation of the efficacy of laser therapy in primary localized amyloidosis(PLCA) only recently starting to materialize, we aimed to review the currently available studies of laser therapy in the management of the disease. We searched PubMed, Scopus, Embase, Web of Science, Cochrane, and ProQuest online databases with a specified search strategy, assessed the quality of each study, and then extracted the eligible data. Five RCTs(randomized controlled trials), one non-randomized controlled trial, three case series, and nine case reports(18 in total) were included. Read More

Orv Hetil 2021 09 19;162(38):1533-1540. Epub 2021 Sep 19.

1 Semmelweis Egyetem, Általános Orvostudományi Kar, Szemészeti Klinika, Budapest, Mária u. 39., 1085.

Összefoglaló. Célkitűzés: A monoklonális gammopathia szemészeti jeleinek és szövődményeinek vizsgálata. Betegek és módszerek: Két nagy budapesti hematológiai ellátóhely 1999 és 2020 között diagnosztizált és/vagy kezelt, monoklonális gammopathiát mutató betegeit vizsgáltuk (42 beteg 84 szeme, 42,86% férfi; átlagéletkor 63,83 ± 10,76 év). Read More

Dermatology 2022 15;238(3):579-586. Epub 2021 Sep 15.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Background: Primary localized cutaneous amyloidosis (PLCA) is defined by the deposition of amyloid protein in the skin without systemic involvement. There are four subtypes of PLCA: lichen amyloidosis (LA), macular amyloidosis (MA), biphasic amyloidosis (BA), and nodular amyloidosis (NA). PLCA occurs most frequently in Latin Americans and Asians. Read More

Am J Clin Dermatol 2021 Sep 21;22(5):667-680. Epub 2021 Jul 21.

Department of Dermatology, American University of Beirut Medical Center, Riad El Solh/Beirut, P.O. Box 11-0236, Beirut, 1107 2020, Lebanon.

Amyloid is a protein derived from at least 20 different substances. Once misfolded, it results in a group of cutaneous and systemic conditions. Primary localized cutaneous amyloidosis of keratinocyte origin is a very common subtype that can manifest either as lichen or macular amyloidosis, lacking systemic involvement. Read More

J Med Chem 2021 07 17;64(13):9010-9041. Epub 2021 Jun 17.

Department of Ophthalmology, Columbia University Medical Center, New York, New York 10032, United States.

Dissociation of transthyretin (TTR) tetramers may lead to misfolding and aggregation of proamyloidogenic monomers, which underlies TTR amyloidosis (ATTR) pathophysiology. ATTR is a progressive disease resulting from the deposition of toxic fibrils in tissues that predominantly presents clinically as amyloid cardiomyopathy and peripheral polyneuropathy. Ligands that bind to and kinetically stabilize TTR tetramers prohibit their dissociation and may prevent ATTR onset. Read More

Dermatol Pract Concept 2021 May 20;11(3):e2021057. Epub 2021 May 20.

Department of Dermatology, S N Medical College, Bagalkot, Karnataka, India.

Background: Primary localized cutaneous amyloidosis (PLCA) causes extracellular proteinaceous deposits in skin. It is clinically divided into macular amyloidosis, lichen amyloidosis and nodular amyloidosis. Atypical presentations of PLCA make the diagnosis challenging, requiring biopsy to confirm amyloid deposition in the upper papillary dermis. Read More

Indian Dermatol Online J 2021 Jan-Feb;12(1):203-205. Epub 2020 Sep 28.

Department of Dermatology, Senior Consultant Dermatologist and Former Director Professor of Dermatology, Dermato-Venereology (Skin/VD) Centre, Sehgal Nursing Home, New Delhi, India.

Dermatol Surg 2021 07;47(7):e205-e211

Dermatology and Laser at Dermatology Unit, Medical Laser Applications-National Institute of Laser Enhanced Sciences (NIlES), Cairo University, Giza, Egypt.

Background: Although various treatments are currently available for primary cutaneous amyloidosis (PCA), there is no entirely satisfactory treatment. Recently, fractional ablative lasers are claimed to have therapeutic effects for PCA.

Objective: To evaluate the efficacy and safety of fractional Er:YAG laser for the treatment of PCA. Read More

Eur J Neurol 2020 12 5;27(12):2635-2640. Epub 2020 Oct 5.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Background And Purpose: Investigating mutation carriers with Dutch-type hereditary (D-) cerebral amyloid angiopathy (CAA), offers the possibility to identify markers in pre- and symptomatic stages of CAA. Optical coherence tomography (OCT) has shown potential to detect retinal changes in several neurodegenerative diseases. The aim of the present exploratory study was to investigate thinning of retinal layers as a possible (early) biomarker in D-CAA mutation carriers. Read More

J Med Chem 2020 10 17;63(19):11054-11084. Epub 2020 Sep 17.

Department of Ophthalmology, Columbia University Medical Center, New York, New York 10032, United States.

Accumulation of cytotoxic lipofuscin bisretinoids may contribute to atrophic age-related macular degeneration (AMD) pathogenesis. Retinal bisretinoid synthesis depends on the influx of serum all--retinol () delivered via a tertiary retinol binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex. We previously identified selective RBP4 antagonists that dissociate circulating RBP4-TTR-retinol complexes, reduce serum RBP4 levels, and inhibit bisretinoid synthesis in models of enhanced retinal lipofuscinogenesis. Read More

Amyloid 2021 Mar 1;28(1):35-41. Epub 2020 Sep 1.

Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Lichen or macular localised cutaneous amyloidoses have long been described as keratinic amyloidoses and believed to be due to the deposition of cytokeratin peptides originating from epidermis in the dermal papillae. However, recently it was suggested that galectin-7 is the causative protein for this type of amyloidosis. This was based on the detection of galectin-7 in a biopsy from a patient diagnosed with Bowen's disease and localised cutaneous amyloidosis. Read More

Retina 2020 Nov;40(11):2099-2105

Vitreous Retina Macula Consultants of New York, New York.

Purpose: To develop a method of averaging optical coherence tomography (OCT) angiography to improve visualization of choriocapillaris structure.

Methods: A stack of OCT angiographic data from vascular layers were placed into the red-green-blue channels of a conventional digital color image. The superficial plexus was placed in the blue channel, choriocapillaris in the green, and deep vascular plexus in the red channel. Read More

PLoS One 2020 29;15(5):e0232785. Epub 2020 May 29.

Huntington Medical Research Institutes, Pasadena, CA, United States of America.

Background: Alzheimer's disease (AD) pathology precedes symptoms and its detection can identify at-risk individuals who may benefit from early treatment. Since the retinal nerve fiber layer (RNFL) is depleted in established AD, we tested whether its thickness can predict whether cognitively healthy (CH) individuals have a normal or pathological cerebrospinal fluid (CSF) Aß42 (A) and tau (T) ratio.

Methods: As part of an ongoing longitudinal study, we enrolled CH individuals, excluding those with cognitive impairment and significant ocular pathology. Read More

Cureus 2020 Apr 9;12(4):e7606. Epub 2020 Apr 9.

Dermatopathology, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, IRN.

Background Although macular amyloidosis is a relatively rare disease, it is a common cutaneous disease in Asia and the Middle East. On hematoxylin and eosin (H&E) stained slides, early lesions could easily be missed without the use of special stains and/or immunohistochemistry. Methods We enrolled 42 patients with the clinical impression of macular amyloidosis who had undergone two 4-mm punch biopsies from 2015 to 2016 at a dermatology clinic affiliated to Shiraz University. Read More

Ophthalmic Genet 2020 06 6;41(3):257-262. Epub 2020 May 6.

Department of Ophthalmology, University of Health Sciences,Ankara Numune Training and Research Hospital , Ankara, Turkey.

Familial Mediterranean fever (FMF) is a hereditary auto-inflammatory disease with accompanying findings of amyloidosis and vasculitis. M694V is one of the most common mutations associated with amyloidosis. This study compared the macular optical coherence tomography angiography measurements in FMF patients who were genetically verified to carry the M694V mutation of the MEFV gene to those in healthy controls. Read More

Dermatol Ther 2020 05 25;33(3):e13305. Epub 2020 Mar 25.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Primary localized cutaneous amyloidosis (PLCA) is a recalcitrant sporadic dermatological condition and most treatments have failed so far. We studied the efficacy of topical dimethyl sulfoxide (DMSO) 50% solution in comparison with tretinoin 0.5% cream in treatment of macular amyloidosis. Read More

Dermatol Ther 2020 05 27;33(3):e13278. Epub 2020 Feb 27.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

The aim of the present study was to investigate the clinical association between rippled pattern pigmentation and the positivity of histopathological analysis for amyloid. A total of 50 patients (90% women) with rippled pattern pigmentation referring to Dermatology Clinic of Shahid Faghihi Hospital, Shiraz, Iran, in 2015 participated in this study. Two biopsies were performed for all the cases from the most frequently affected sites. Read More

Lasers Med Sci 2020 Jul 8;35(5):1171-1177. Epub 2020 Jan 8.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Macular amyloidosis (MA) is a common form of primary localized cutaneous amyloidosis, characterized by the eruption of brown pigments of the skin with a rippled pattern. MA can be of cosmetic concern for patients, and its treatment is challenging. In this study, we aimed to find new effective approaches for MA treatment. Read More

J Cosmet Dermatol 2020 Jun 19;19(6):1479-1480. Epub 2019 Sep 19.

Department of Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

A 28-year-old male presented with multiple pigmented macules on his right temple over two years. Physical examination showed multiple, discrete, brownish macules on his right temple. These lesions coalesced into reticular shape. Read More

J Dermatolog Treat 2020 Dec 29;31(8):846-849. Epub 2019 Aug 29.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

A transcutaneous electrical nerve stimulation (TENS) unit is an inexpensive, accessible therapeutic device with multiple dermatology-related uses. This review aims to describe the dermatological applications of TENS. PubMed was searched for literature related to TENS in dermatology. Read More

J Dermatolog Treat 2021 Mar 25;32(2):258-260. Epub 2019 Aug 25.

Dr Radmanesh Dermatologic and Laser Center, Tehran, Iran.

Background: No topical and systemic treatment is proven to be effective on Cutaneous Macular Amyloidosis (CMA). The physical removal of the deposited protein by lasers may be a better choice.

Objective: To compare the efficacy of different lasers including Pulsed dye laser (PDL), 1064 mode of Q-Switched Nd-YAG, CO, and combined CO and Q-Switched Nd:YAG lasers for the treatment of CMA. Read More

J Dermatolog Treat 2021 May 29;32(3):340-344. Epub 2019 Aug 29.

Health Faculty, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: This aim of this study was to determine the effect of 1540-nm nonablative fractional erbium on macular amyloidosis.

Methods: This phase-II clinical trial study has been performed with parallel group with blinding of the evaluator. The skin lesions of the patients (15 patients and 30 lesions) with cutaneous macular amyloidosis were randomly assigned into laser and no-treatment groups. Read More

BMJ Case Rep 2019 May 6;12(5). Epub 2019 May 6.

Department of Dermatology, Queen Elizabeth University Hospital, Glasgow, UK.

Nodular primary localised cutaneous amyloidosis (NPLCA) is the rarest form of cutaneous amyloidosis, with a predilection for facial and acral skin. We present a 63-year-old Caucasian with a 10-year history of an asymptomatic plaque on his left cheek, starting 2 years after being scratched by a cat in the same area. A biopsy showed nodules of eosinophilic material in the deep dermis and subcutaneous fat, with plasma cells in the dermis. Read More