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Indian Dermatol Online J 2021 Jan-Feb;12(1):203-205. Epub 2020 Sep 28.

Department of Dermatology, Senior Consultant Dermatologist and Former Director Professor of Dermatology, Dermato-Venereology (Skin/VD) Centre, Sehgal Nursing Home, New Delhi, India.

Dermatol Surg 2021 Mar 9. Epub 2021 Mar 9.

Dermatology Department, Kasr Al Aini Hospital, Faculty of Medicine, Cairo University, ICDP-UEMS, Giza, Egypt; Histology Department, Faculty of Medicine, Cairo University, Giza, Egypt; Ahmed Maher Teaching Hospital, Cairo, Egypt; Dermatology and Laser at Dermatology Unit, Medical Laser Applications-National Institute of Laser Enhanced Sciences (NIlES), Cairo University, Giza, Egypt.

Background: Although various treatments are currently available for primary cutaneous amyloidosis (PCA), there is no entirely satisfactory treatment. Recently, fractional ablative lasers are claimed to have therapeutic effects for PCA.

Objective: To evaluate the efficacy and safety of fractional Er:YAG laser for the treatment of PCA. Read More

J Med Chem 2020 10 17;63(19):11054-11084. Epub 2020 Sep 17.

Department of Ophthalmology, Columbia University Medical Center, New York, New York 10032, United States.

Accumulation of cytotoxic lipofuscin bisretinoids may contribute to atrophic age-related macular degeneration (AMD) pathogenesis. Retinal bisretinoid synthesis depends on the influx of serum all--retinol () delivered via a tertiary retinol binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex. We previously identified selective RBP4 antagonists that dissociate circulating RBP4-TTR-retinol complexes, reduce serum RBP4 levels, and inhibit bisretinoid synthesis in models of enhanced retinal lipofuscinogenesis. Read More

Amyloid 2021 Mar 1;28(1):35-41. Epub 2020 Sep 1.

Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Lichen or macular localised cutaneous amyloidoses have long been described as keratinic amyloidoses and believed to be due to the deposition of cytokeratin peptides originating from epidermis in the dermal papillae. However, recently it was suggested that galectin-7 is the causative protein for this type of amyloidosis. This was based on the detection of galectin-7 in a biopsy from a patient diagnosed with Bowen's disease and localised cutaneous amyloidosis. Read More

Retina 2020 Nov;40(11):2099-2105

Vitreous Retina Macula Consultants of New York, New York.

Purpose: To develop a method of averaging optical coherence tomography (OCT) angiography to improve visualization of choriocapillaris structure.

Methods: A stack of OCT angiographic data from vascular layers were placed into the red-green-blue channels of a conventional digital color image. The superficial plexus was placed in the blue channel, choriocapillaris in the green, and deep vascular plexus in the red channel. Read More

PLoS One 2020 29;15(5):e0232785. Epub 2020 May 29.

Huntington Medical Research Institutes, Pasadena, CA, United States of America.

Background: Alzheimer's disease (AD) pathology precedes symptoms and its detection can identify at-risk individuals who may benefit from early treatment. Since the retinal nerve fiber layer (RNFL) is depleted in established AD, we tested whether its thickness can predict whether cognitively healthy (CH) individuals have a normal or pathological cerebrospinal fluid (CSF) Aß42 (A) and tau (T) ratio.

Methods: As part of an ongoing longitudinal study, we enrolled CH individuals, excluding those with cognitive impairment and significant ocular pathology. Read More

Cureus 2020 Apr 9;12(4):e7606. Epub 2020 Apr 9.

Dermatopathology, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, IRN.

Background Although macular amyloidosis is a relatively rare disease, it is a common cutaneous disease in Asia and the Middle East. On hematoxylin and eosin (H&E) stained slides, early lesions could easily be missed without the use of special stains and/or immunohistochemistry. Methods We enrolled 42 patients with the clinical impression of macular amyloidosis who had undergone two 4-mm punch biopsies from 2015 to 2016 at a dermatology clinic affiliated to Shiraz University. Read More

Ophthalmic Genet 2020 06 6;41(3):257-262. Epub 2020 May 6.

Department of Ophthalmology, University of Health Sciences,Ankara Numune Training and Research Hospital , Ankara, Turkey.

Familial Mediterranean fever (FMF) is a hereditary auto-inflammatory disease with accompanying findings of amyloidosis and vasculitis. M694V is one of the most common mutations associated with amyloidosis. This study compared the macular optical coherence tomography angiography measurements in FMF patients who were genetically verified to carry the M694V mutation of the MEFV gene to those in healthy controls. Read More

Dermatol Ther 2020 05 25;33(3):e13305. Epub 2020 Mar 25.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Primary localized cutaneous amyloidosis (PLCA) is a recalcitrant sporadic dermatological condition and most treatments have failed so far. We studied the efficacy of topical dimethyl sulfoxide (DMSO) 50% solution in comparison with tretinoin 0.5% cream in treatment of macular amyloidosis. Read More

Dermatol Ther 2020 05 27;33(3):e13278. Epub 2020 Feb 27.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

The aim of the present study was to investigate the clinical association between rippled pattern pigmentation and the positivity of histopathological analysis for amyloid. A total of 50 patients (90% women) with rippled pattern pigmentation referring to Dermatology Clinic of Shahid Faghihi Hospital, Shiraz, Iran, in 2015 participated in this study. Two biopsies were performed for all the cases from the most frequently affected sites. Read More

Lasers Med Sci 2020 Jul 8;35(5):1171-1177. Epub 2020 Jan 8.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Macular amyloidosis (MA) is a common form of primary localized cutaneous amyloidosis, characterized by the eruption of brown pigments of the skin with a rippled pattern. MA can be of cosmetic concern for patients, and its treatment is challenging. In this study, we aimed to find new effective approaches for MA treatment. Read More

J Cosmet Dermatol 2020 Jun 19;19(6):1479-1480. Epub 2019 Sep 19.

Department of Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

A 28-year-old male presented with multiple pigmented macules on his right temple over two years. Physical examination showed multiple, discrete, brownish macules on his right temple. These lesions coalesced into reticular shape. Read More

J Dermatolog Treat 2020 Dec 29;31(8):846-849. Epub 2019 Aug 29.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

A transcutaneous electrical nerve stimulation (TENS) unit is an inexpensive, accessible therapeutic device with multiple dermatology-related uses. This review aims to describe the dermatological applications of TENS. PubMed was searched for literature related to TENS in dermatology. Read More

J Dermatolog Treat 2021 Mar 25;32(2):258-260. Epub 2019 Aug 25.

Dr Radmanesh Dermatologic and Laser Center, Tehran, Iran.

Background: No topical and systemic treatment is proven to be effective on Cutaneous Macular Amyloidosis (CMA). The physical removal of the deposited protein by lasers may be a better choice.

Objective: To compare the efficacy of different lasers including Pulsed dye laser (PDL), 1064 mode of Q-Switched Nd-YAG, CO, and combined CO and Q-Switched Nd:YAG lasers for the treatment of CMA. Read More

J Dermatolog Treat 2019 Aug 29:1-5. Epub 2019 Aug 29.

Health Faculty, Mashhad University of Medical Sciences , Mashhad , Iran.

This aim of this study was to determine the effect of 1540-nm nonablative fractional erbium on macular amyloidosis. This phase-II clinical trial study has been performed with parallel group with blinding of the evaluator. The skin lesions of the patients (15 patients and 30 lesions) with cutaneous macular amyloidosis were randomly assigned into laser and no-treatment groups. Read More

BMJ Case Rep 2019 May 6;12(5). Epub 2019 May 6.

Department of Dermatology, Queen Elizabeth University Hospital, Glasgow, UK.

Nodular primary localised cutaneous amyloidosis (NPLCA) is the rarest form of cutaneous amyloidosis, with a predilection for facial and acral skin. We present a 63-year-old Caucasian with a 10-year history of an asymptomatic plaque on his left cheek, starting 2 years after being scratched by a cat in the same area. A biopsy showed nodules of eosinophilic material in the deep dermis and subcutaneous fat, with plasma cells in the dermis. Read More

Dermatol Online J 2019 Apr 15;25(4). Epub 2019 Apr 15.

Develi State Hospital, Department of Dermatology and Venereology, Kayseri.

Amyloidosis cutis dyschromica (ACD) is a rare form of primary cutaneous amyloidosis. ACD, first described by Morishima in 1970 is characterized by (i) macular, speckled, reticular hyperpigmentation with hypopigmented spots distributed extensively over the body; (ii) little or no pruritus; (iii) prepubertal onset; and (iv) focal subepidermal amyloid deposition. A 49-year-old woman presented with a 20-year history of progressive, asymptomatic, generalized mottled hyper- and hypopigmented macules all over the body. Read More

Australas J Dermatol 2019 Aug 13;60(3):e248-e249. Epub 2019 Mar 13.

Dermatology Unit, University of Campania, Naples, Italy.

SAGE Open Med Case Rep 2019 15;7:2050313X19829617. Epub 2019 Feb 15.

Division of Dermatology, University of Alberta, Edmonton, AB, Canada.

Primary cutaneous amyloidosis is characterized by polymerization of extracellular amyloid precursors in β-pleated sheet conformation into larger fibrillar aggregates. Observation in models of Alzheimer's disease have noted that amyloid polymerization in the brain is blocked by reactive oxygen species. Singlet oxygen is formed in the skin during methyl aminolevulinate photodynamic therapy. Read More

Indian J Dermatol 2019 Jan-Feb;64(1):28-33

Department of Dermatology, IPGMER, Kolkata, West Bengal, India.

Introduction: Primary cutaneous amyloidosis (PCA) can be classified into four principal categories: macular amyloidosis, lichen amyloidosis, biphasic, and nodular amyloidosis. Some unusual variants such as widespread diffuse hyperpigmentation without papules, poikiloderma like involvement, lesions following Blaschko's line, etc., have also been reported. Read More

Clin Exp Dermatol 2019 Jun 7;44(4):e110-e117. Epub 2019 Feb 7.

Dermatology Hospital, Southern Medical University, Guangzhou, China.

Background: Primary localized cutaneous amyloidosis (PLCA) is a chronic pruritic skin disorder. The genetic basis of familial (f)PLCA involves mutations in the oncostatin M receptor (OSMR) and interleukin-31 receptor A (IL31RA) genes, but the disease pathophysiology is not fully understood.

Aim: To investigate the OSMR mutation spectrum in patients with sporadic (s)PLCA/fPLCA, lichen/macular PLCA in mainland China. Read More

Dermatol Online J 2018 Sep 15;24(9). Epub 2018 Sep 15.

Duke University Medical Center, Department of Dermatology, Durham, North Carolina.

Primary cutaneous amyloidosis may be characterized as macular amyloidosis, lichenoid amyloidosis, or nodular amyloidosis. Nodular amyloidosis results from the deposition of immunoglobulin light chains and may rarely be associated with systemic amyloidosis. We report an unusual case of a patient with systemic scleroderma who developed primary cutaneous nodular amyloidosis on the left lower leg. Read More

Am J Dermatopathol 2019 May;41(5):382-385

Department of Dermatology, Chapel Allerton Hospital, Leeds, United Kingdom.

Primary localized cutaneous amyloidosis is a group of rare conditions where amyloid deposition is limited to the skin without systemic manifestations. Most cases are sporadic; however, mutations in the oncostatin M receptor (OSMR) and interleukin-31 receptor A (IL31RA) genes can cause a familial form of the condition in up to 10% of cases. Here, we describe a family in which 8 female individuals are affected by either macular amyloidosis or amyloidosis cutis dyschromica. Read More

J Cosmet Dermatol 2018 12 11;17(6):1293-1294. Epub 2018 Jul 11.

Department of Dermatology & STD, Lady Hardinge Medical College and Associated Hospital, New Delhi, India.

J Clin Aesthet Dermatol 2018 Apr 1;11(4):25-27. Epub 2018 Apr 1.

Drs. Awal and Kaur are with the Department of Dermatology, Venereology & Leprosy, Sri Guru Ram Das Institute of Medical Sciences and Research in Amritsar, India.

Neurodegenerative disorders such as Alzheimer's disease and localized cutaneous macular amyloidosis are conditions that result from protein misfolding. These disorders share common pathogenic mechanisms that lead to the deposition of amyloid protein. Currently, there is a paucity of data on the connection between the brain and skin amyloidosis. Read More

Lasers Med Sci 2018 May 26;33(4):909-916. Epub 2018 Feb 26.

Ministry of Health Hospital, Cairo, Egypt.

Macular amyloidosis (MA) represents a common variant of primary localized cutaneous amyloidosis. It has a characteristic female predominance; none of the treatment modalities described is either curative or uniformly effective in patients with macular amyloidosis. To determine the effect of fractional CO laser in macular amyloidosis in comparison to fractional CO laser-assisted drug delivery of topical steroids and topical vitamin C, the study includes 10 female patients with cutaneous macular amyloidosis aged between 20 and 62 years. Read More

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology and STD, Lady Hardinge Medical College. New Delhi, India.

Primary localized cutaneous amyloidosis refers to a group of disorders characterized by deposition of amyloid in the dermis without any systemic involvement. It comprises the following clinical types: macular, lichenoid, nodular, and biphasic. There are also rare variants such as amyloidosis cutis dyscromica and poikiloderma-like cutaneous amyloidosis. Read More

Neurology 2018 01 13;90(2):e142-e148. Epub 2017 Dec 13.

From the Intramural Research Program (C.Q., J.D., Q.Z., L.J.L.), Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD; Aging Research Center (C.Q.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Sweden; Icelandic Heart Association (S.S., G.E., V.G.), Kopavogur; Division of Epidemiology and Clinical Research (D.E.F., M.F.C.), National Eye Institute, NIH, Bethesda, MD; Ophthalmology and Visual Sciences (R.K.), University of Wisconsin Madison; Department of Radiology (M.A.v.B.), Leiden University Medical Centre, the Netherlands; and Faculty of Medicine (V.G.), University of Iceland, Reykjavik.

Objective: To test the hypothesis that age-related macular degeneration (AMD) and retinal microvascular signs are differentially associated with lobar and deep cerebral microbleeds (CMBs).

Methods: CMBs in lobar regions indicate cerebral amyloid angiopathy (CAA). β-Amyloid deposits are implicated in both CAA and AMD. Read More

Indian Dermatol Online J 2017 Nov-Dec;8(6):499-501

Department of Pathology, VMCC and Safdarjang Hospital, New Delhi, India.