392 results match your criteria Amyloidosis Lichen

A Case of Lichen Amyloidosis Successfully Treated with Alitretinoin.

Indian J Dermatol 2022 Jan-Feb;67(1):95

Department of Dermatology, Inje University Sanggye Paik Hospital, Seoul, Korea. E-mail:

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Lichen Amyloidosis on the Scalp: A Case Report.

Clin Cosmet Investig Dermatol 2022 20;15:721-723. Epub 2022 Apr 20.

Department of Dermatology, Peking University People's Hospital, Beijing, People's Republic of China.

Lichen amyloidosis (LA) is one form of primary cutaneous amyloidosis, presented as discrete, lichenoid papules with itching, commonly involving the extensor surfaces of extremities. Scalp involvement is rarely reported in the literature. In this study, we reported a case of LA over the crown and vertex areas of the scalp. Read More

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Diagnosing of primary cutaneous amyloidosis using dermoscopy and reflectance confocal microscopy.

Wang Lei Xu Ai-E

Skin Res Technol 2022 May 21;28(3):433-438. Epub 2022 Feb 21.

Department of Dermatology, Third People's Hospital of Hangzhou, Hangzhou, China.

Background: Primary cutaneous amyloidosis (PCA) is apruritic and potentially disfiguring disorder; this disease is usually diagnosed clinically due to its common occurrence. However, for cases with atypical presentations or for those physicians not familiar with PCA, the diagnosis can be a challenge.

Objective: To observe the characteristics of PCA under dermoscopy and reflectance confocal microscopy (RCM) in order to gain experience and reference for clinicians to facilitate diagnosis. Read More

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Anosacral amyloidosis in a Chinese-Caribbean male.

JAAD Case Rep 2022 Mar 6;21:46-48. Epub 2022 Jan 6.

Department of Dermatology & Cutaneous Surgery, University of South Florida, Tampa, Florida.

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Dermoscopic Features of Lichen Amyloidosis in Caucasians-A Case Series and Literature Review.

Medicina (Kaunas) 2021 Sep 27;57(10). Epub 2021 Sep 27.

Department of Dermatology, Institute of Medical Sciences, Medical College, Rzeszow University, 35-310 Rzeszów, Poland.

Primary cutaneous amyloidosis (PCA) is characterized by the extracellular deposition of amyloid in the skin without systemic involvement. It comprises several clinical variants, the most common of which are macular amyloidosis (MA) and lichen amyloidosis (LA). PCA is frequently observed in Asians, while it is considered to be very rare in Caucasians. Read More

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September 2021

The therapeutic role of lasers in primary localized cutaneous amyloidosis: a systematic review.

Lasers Med Sci 2022 Mar 6;37(2):799-813. Epub 2021 Oct 6.

Faculty of Medicine, Kerman University of Medical Sciences, Haft Bagh Alavi Blvd, Postal Code: 7616913555, Kerman, Iran.

With the investigation of the efficacy of laser therapy in primary localized amyloidosis(PLCA) only recently starting to materialize, we aimed to review the currently available studies of laser therapy in the management of the disease. We searched PubMed, Scopus, Embase, Web of Science, Cochrane, and ProQuest online databases with a specified search strategy, assessed the quality of each study, and then extracted the eligible data. Five RCTs(randomized controlled trials), one non-randomized controlled trial, three case series, and nine case reports(18 in total) were included. Read More

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Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland.

Dermatology 2022 15;238(3):579-586. Epub 2021 Sep 15.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Background: Primary localized cutaneous amyloidosis (PLCA) is defined by the deposition of amyloid protein in the skin without systemic involvement. There are four subtypes of PLCA: lichen amyloidosis (LA), macular amyloidosis (MA), biphasic amyloidosis (BA), and nodular amyloidosis (NA). PLCA occurs most frequently in Latin Americans and Asians. Read More

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Efficacy of 1064-nm Nd:YAG picosecond laser in lichen amyloidosis treatment: clinical and dermoscopic evaluation.

J Cosmet Laser Ther 2021 May 8;23(3-4):55-58. Epub 2021 Sep 8.

Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Pathumwan, Bangkok, Thailand.

Lichen amyloidosis (LA) is a type of primary localized cutaneous amyloidosis characterized by multiple localized, hyperpigmented, grouped papules, in which the deposition of amyloid materials from altered keratinocytes usually resists to current treatments. We presented two LA patients with non-satisfactory results of topical treatments. After the first treatment using 1064-nm Nd: YAG picosecond (ps-Nd:YAG) laser, there was an improvement with persistence up to 3-month follow up after five sessions of 4-week interval, as well as a decrease in number, thickness, and darkness of lesions from clinical and dermoscopic evaluation. Read More

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Dermoscopic Evaluation of Inflammatory Nail Disorders and Their Mimics.

Acta Derm Venereol 2021 Sep 15;101(9):adv00548. Epub 2021 Sep 15.

Alfred Health, Melbourne, Australia.

Nail dermoscopy (onychoscopy) is a valuable diagnostic tool for evaluating diseases in the nail apparatus. It is non-invasive, allowing clinicians to prioritize particular nails for biopsy. Thus, it can improve diagnostic accuracy and expedite treatment. Read More

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September 2021

Primary Localized Cutaneous Amyloidosis of Keratinocyte Origin: An Update with Emphasis on Atypical Clinical Variants.

Am J Clin Dermatol 2021 Sep 21;22(5):667-680. Epub 2021 Jul 21.

Department of Dermatology, American University of Beirut Medical Center, Riad El Solh/Beirut, P.O. Box 11-0236, Beirut, 1107 2020, Lebanon.

Amyloid is a protein derived from at least 20 different substances. Once misfolded, it results in a group of cutaneous and systemic conditions. Primary localized cutaneous amyloidosis of keratinocyte origin is a very common subtype that can manifest either as lichen or macular amyloidosis, lacking systemic involvement. Read More

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September 2021

Dermoscopic diagnosis of notalgia paresthetica.

Agri 2021 Jan;33(1):50-51

Department of Pathology, Kırşehir Ahi Evran University Faculty of Medicine, Kırşehir, Turkey.

Dermoscopic examination is a very effective and practical method that significantly reduces the need for invasive diagnostic procedures in many skin diseases. Dermoscopic features of many cutaneous conditions have been well described, however, only one single case report has defined dermoscopic features of notalgia paresthetica so far. The clinical presentation of this entity can mimic many dermatological conditions including lichen simplex chronicus, cutaneous amyloidosis, and tinea versicolor. Read More

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January 2021

Elevated basal serum levels of calcitonin and simultaneous surgery of MEN2A-specific tumors.

Neoplasma 2021 Sep 23;68(5):1098-1106. Epub 2021 Jun 23.

Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Wenzhou Medical University, Hangzhou, Zhejiang, China.

Multiple endocrine neoplasia type 2A (MEN2A) is a rare syndrome caused almost by germline RET mutation, and characterized by medullary thyroid carcinoma (MTC), in combination or not with pheochromocytoma (PHEO), hyperparathyroidism (HPTH), cutaneous lichen amyloidosis (CLA), and Hirschsprung's disease (HD). The basal serum calcitonin (Ctn)/carcinoembryonic antigen (CEA) levels are significantly correlated with the MTC stage. Metachronous surgery of MEN2A-specific tumors is a routine procedure. Read More

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September 2021

FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis.

Dermatol Pract Concept 2021 May 20;11(3):e2021057. Epub 2021 May 20.

Department of Dermatology, S N Medical College, Bagalkot, Karnataka, India.

Background: Primary localized cutaneous amyloidosis (PLCA) causes extracellular proteinaceous deposits in skin. It is clinically divided into macular amyloidosis, lichen amyloidosis and nodular amyloidosis. Atypical presentations of PLCA make the diagnosis challenging, requiring biopsy to confirm amyloid deposition in the upper papillary dermis. Read More

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A case of lichen amyloidosis associated with atopic dermatitis successfully treated with dupilumab: A case report and literature review.

Dermatol Ther 2021 07 3;34(4):e15005. Epub 2021 Jun 3.

Department of Dermatology, Kyorin University Faculty of Medicine, Tokyo, Japan.

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Multiple endocrine neoplasia type 2: A review.

Semin Cancer Biol 2022 02 1;79:163-179. Epub 2021 Apr 1.

Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Institute of Clinical Medicine, Faculty of Health Sciences, Copenhagen University, Copenhagen, Denmark.

Multiple endocrine neoplasias are rare hereditary syndromes some of them with malignant potential. Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary cancer syndrome due to germline variants in the REarranged during Transfection (RET) proto-oncogene. There are two distinct clinical entities: MEN 2A and MEN 2B. Read More

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February 2022

Fractional Erbium-Doped Yttrium Aluminum Garnet Laser in the Treatment of Primary Cutaneous Amyloidosis.

Dermatol Surg 2021 07;47(7):e205-e211

Dermatology and Laser at Dermatology Unit, Medical Laser Applications-National Institute of Laser Enhanced Sciences (NIlES), Cairo University, Giza, Egypt.

Background: Although various treatments are currently available for primary cutaneous amyloidosis (PCA), there is no entirely satisfactory treatment. Recently, fractional ablative lasers are claimed to have therapeutic effects for PCA.

Objective: To evaluate the efficacy and safety of fractional Er:YAG laser for the treatment of PCA. Read More

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Dermatoscopic features of lichen amyloidosis: A case report.

Australas J Dermatol 2021 May 9;62(2):e356-e357. Epub 2021 Feb 9.

Dermatology Department, Hospital Universitario "Dr José Eleuterio González" Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

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Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy.

Dermatol Online J 2020 Dec 15;26(12). Epub 2020 Dec 15.

Vital Dermatology, Pensacola, FL.

Lichen amyloidosis is a subtype of primary localized cutaneous amyloidosis characterized by deposition of amyloid protein in the skin without visceral involvement. Although it is usually limited to localized areas of the body, it rarely can present in a generalized fashion and is severely pruritic. The limited form is treated with skin directed therapies such as topical or intralesional corticosteroids or topical tacrolimus but the generalized type is more difficult to treat. Read More

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December 2020

Treatment of lichen amyloidosis with fractional CO laser and topical steroid: a preliminary study of 10 cases.

Lasers Med Sci 2021 07 24;36(5):1123-1127. Epub 2020 Nov 24.

Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.

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A case report and differential diagnosis of pruritic pretibial skin lesions.

Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):157-159

Department of Dermatovenerology, Ljubljana Medical Center, Ljubljana, Slovenia.

Pretibial pruritic papular dermatitis (PPPD) is a clinical entity first described in 2006. The etiology is uncertain; however, gentle chronic rubbing is likely to be the reason for the skin reaction. Pretibial pruritic lesions may reflect many different systemic diseases and dermatoses. Read More

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September 2020

Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7.

Amyloid 2021 Mar 1;28(1):35-41. Epub 2020 Sep 1.

Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Lichen or macular localised cutaneous amyloidoses have long been described as keratinic amyloidoses and believed to be due to the deposition of cytokeratin peptides originating from epidermis in the dermal papillae. However, recently it was suggested that galectin-7 is the causative protein for this type of amyloidosis. This was based on the detection of galectin-7 in a biopsy from a patient diagnosed with Bowen's disease and localised cutaneous amyloidosis. Read More

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Multiple endocrine neoplasia type 2A with cutaneous lichen amyloidosis.

BMJ Case Rep 2020 Aug 26;13(8). Epub 2020 Aug 26.

Endocrinology and Metabolism, Army Hospital Research & Referral, New Delhi, Delhi, India.

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A primer on the genetics of medullary thyroid cancer.

Curr Oncol 2019 12 1;26(6):389-394. Epub 2019 Dec 1.

Endocrine Oncology Site Group, Princess Margaret Cancer Centre, Toronto, ON.

Medullary thyroid cancer is a rare type of neuroendocrine tumour that arises from the parafollicular cells (C cells) of the thyroid gland. It accounts for 3%-5% of thyroid cancer cases. Close to 25% of cases are familial, and 75% are considered sporadic. Read More

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December 2019

A Rare Presentation of Nodular Amyloidosis on the Lower Back.

Cureus 2019 Oct 8;11(10):e5864. Epub 2019 Oct 8.

Dermatology, St. Joseph Dermatopathology, Houston, USA.

Primary localized cutaneous amyloidosis (PLCA) occurs when amyloid is deposited only within the skin and there is no evidence of systemic involvement. Nodular amyloidosis is the rarest subtype of PLCA. It typically involves the acral regions but can sometimes present on the head and neck. Read More

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October 2019

Transcutaneous electrical nerve stimulation (TENS): a review of applications in dermatology.

J Dermatolog Treat 2020 Dec 29;31(8):846-849. Epub 2019 Aug 29.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

A transcutaneous electrical nerve stimulation (TENS) unit is an inexpensive, accessible therapeutic device with multiple dermatology-related uses. This review aims to describe the dermatological applications of TENS. PubMed was searched for literature related to TENS in dermatology. Read More

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December 2020

Symmetric lichen amyloidosis: an atypical location on the bilateral extensor surfaces of the arms.

Cutis 2019 Apr;103(4):E9-E10

Division of Dermatology, Ronald Reagan UCLA Medical Center, Los Angeles, USA.

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Clinicopathological Study of Primary Cutaneous Amyloidosis in a Tertiary Care Center of Eastern India Reveals Insignificant Association with Friction, Scrubbing, and Photo-Exposure: How valid is the "Keratinocyte Hypothesis"?

Indian J Dermatol 2019 Jan-Feb;64(1):28-33

Department of Dermatology, IPGMER, Kolkata, West Bengal, India.

Introduction: Primary cutaneous amyloidosis (PCA) can be classified into four principal categories: macular amyloidosis, lichen amyloidosis, biphasic, and nodular amyloidosis. Some unusual variants such as widespread diffuse hyperpigmentation without papules, poikiloderma like involvement, lesions following Blaschko's line, etc., have also been reported. Read More

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February 2019

Clinical and genetic features of Chinese patients with lichen and macular primary localized cutaneous amyloidosis.

Clin Exp Dermatol 2019 Jun 7;44(4):e110-e117. Epub 2019 Feb 7.

Dermatology Hospital, Southern Medical University, Guangzhou, China.

Background: Primary localized cutaneous amyloidosis (PLCA) is a chronic pruritic skin disorder. The genetic basis of familial (f)PLCA involves mutations in the oncostatin M receptor (OSMR) and interleukin-31 receptor A (IL31RA) genes, but the disease pathophysiology is not fully understood.

Aim: To investigate the OSMR mutation spectrum in patients with sporadic (s)PLCA/fPLCA, lichen/macular PLCA in mainland China. Read More

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