381 results match your criteria Amyloidosis Lichen

Elevated basal serum levels of calcitonin and simultaneous surgery of MEN2A-specific tumors.

Neoplasma 2021 Jun 23. Epub 2021 Jun 23.

Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Wenzhou Medical University, Hangzhou, Zhejiang, China.

Multiple endocrine neoplasia type 2A (MEN2A) is a rare syndrome caused almost by germline RET mutation, and characterized by medullary thyroid carcinoma (MTC), in combination or not with pheochromocytoma (PHEO), hyperparathyroidism (HPTH), cutaneous lichen amyloidosis (CLA), and Hirschsprung's disease (HD). The basal serum calcitonin (Ctn)/carcinoembryonic antigen (CEA) levels are significantly correlated with the MTC stage. Metachronous surgery of MEN2A-specific tumors is a routine procedure. Read More

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FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis.

Dermatol Pract Concept 2021 May 20;11(3):e2021057. Epub 2021 May 20.

Department of Dermatology, S N Medical College, Bagalkot, Karnataka, India.

Background: Primary localized cutaneous amyloidosis (PLCA) causes extracellular proteinaceous deposits in skin. It is clinically divided into macular amyloidosis, lichen amyloidosis and nodular amyloidosis. Atypical presentations of PLCA make the diagnosis challenging, requiring biopsy to confirm amyloid deposition in the upper papillary dermis. Read More

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A case of lichen amyloidosis associated with atopic dermatitis successfully treated with dupilumab: A case report and literature review.

Dermatol Ther 2021 May 26:e15005. Epub 2021 May 26.

Department of Dermatology, Kyorin University Faculty of Medicine, Tokyo, Japan.

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Multiple endocrine neoplasia type 2: A reveiw.

Semin Cancer Biol 2021 Apr 1. Epub 2021 Apr 1.

Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Institute of Clinical Medicine, Faculty of Health Sciences, Copenhagen University, Copenhagen, Denmark. Electronic address:

Multiple endocrine neoplasias are rare hereditary syndromes some of them with malignant potential. Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary cancer syndrome due to germline variants in the REarranged during Transfection (RET) proto-oncogene. There are two distinct clinical entities: MEN 2A and MEN 2B. Read More

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Fractional Erbium-Doped Yttrium Aluminum Garnet Laser in the Treatment of Primary Cutaneous Amyloidosis.

Dermatol Surg 2021 Jul;47(7):e205-e211

Dermatology and Laser at Dermatology Unit, Medical Laser Applications-National Institute of Laser Enhanced Sciences (NIlES), Cairo University, Giza, Egypt.

Background: Although various treatments are currently available for primary cutaneous amyloidosis (PCA), there is no entirely satisfactory treatment. Recently, fractional ablative lasers are claimed to have therapeutic effects for PCA.

Objective: To evaluate the efficacy and safety of fractional Er:YAG laser for the treatment of PCA. Read More

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Dermatoscopic features of lichen amyloidosis: A case report.

Australas J Dermatol 2021 May 9;62(2):e356-e357. Epub 2021 Feb 9.

Dermatology Department, Hospital Universitario "Dr José Eleuterio González" Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

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Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy.

Dermatol Online J 2020 Dec 15;26(12). Epub 2020 Dec 15.

Vital Dermatology, Pensacola, FL.

Lichen amyloidosis is a subtype of primary localized cutaneous amyloidosis characterized by deposition of amyloid protein in the skin without visceral involvement. Although it is usually limited to localized areas of the body, it rarely can present in a generalized fashion and is severely pruritic. The limited form is treated with skin directed therapies such as topical or intralesional corticosteroids or topical tacrolimus but the generalized type is more difficult to treat. Read More

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December 2020

Treatment of lichen amyloidosis with fractional CO laser and topical steroid: a preliminary study of 10 cases.

Lasers Med Sci 2021 Jul 24;36(5):1123-1127. Epub 2020 Nov 24.

Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.

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A case report and differential diagnosis of pruritic pretibial skin lesions.

Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):157-159

Department of Dermatovenerology, Ljubljana Medical Center, Ljubljana, Slovenia.

Pretibial pruritic papular dermatitis (PPPD) is a clinical entity first described in 2006. The etiology is uncertain; however, gentle chronic rubbing is likely to be the reason for the skin reaction. Pretibial pruritic lesions may reflect many different systemic diseases and dermatoses. Read More

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September 2020

Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7.

Amyloid 2021 Mar 1;28(1):35-41. Epub 2020 Sep 1.

Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Lichen or macular localised cutaneous amyloidoses have long been described as keratinic amyloidoses and believed to be due to the deposition of cytokeratin peptides originating from epidermis in the dermal papillae. However, recently it was suggested that galectin-7 is the causative protein for this type of amyloidosis. This was based on the detection of galectin-7 in a biopsy from a patient diagnosed with Bowen's disease and localised cutaneous amyloidosis. Read More

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Multiple endocrine neoplasia type 2A with cutaneous lichen amyloidosis.

BMJ Case Rep 2020 Aug 26;13(8). Epub 2020 Aug 26.

Endocrinology and Metabolism, Army Hospital Research & Referral, New Delhi, Delhi, India.

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A primer on the genetics of medullary thyroid cancer.

Curr Oncol 2019 12 1;26(6):389-394. Epub 2019 Dec 1.

Endocrine Oncology Site Group, Princess Margaret Cancer Centre, Toronto, ON.

Medullary thyroid cancer is a rare type of neuroendocrine tumour that arises from the parafollicular cells (C cells) of the thyroid gland. It accounts for 3%-5% of thyroid cancer cases. Close to 25% of cases are familial, and 75% are considered sporadic. Read More

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December 2019

A Rare Presentation of Nodular Amyloidosis on the Lower Back.

Cureus 2019 Oct 8;11(10):e5864. Epub 2019 Oct 8.

Dermatology, St. Joseph Dermatopathology, Houston, USA.

Primary localized cutaneous amyloidosis (PLCA) occurs when amyloid is deposited only within the skin and there is no evidence of systemic involvement. Nodular amyloidosis is the rarest subtype of PLCA. It typically involves the acral regions but can sometimes present on the head and neck. Read More

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October 2019

Transcutaneous electrical nerve stimulation (TENS): a review of applications in dermatology.

J Dermatolog Treat 2020 Dec 29;31(8):846-849. Epub 2019 Aug 29.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

A transcutaneous electrical nerve stimulation (TENS) unit is an inexpensive, accessible therapeutic device with multiple dermatology-related uses. This review aims to describe the dermatological applications of TENS. PubMed was searched for literature related to TENS in dermatology. Read More

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December 2020

Symmetric lichen amyloidosis: an atypical location on the bilateral extensor surfaces of the arms.

Cutis 2019 Apr;103(4):E9-E10

Division of Dermatology, Ronald Reagan UCLA Medical Center, Los Angeles, USA.

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Clinicopathological Study of Primary Cutaneous Amyloidosis in a Tertiary Care Center of Eastern India Reveals Insignificant Association with Friction, Scrubbing, and Photo-Exposure: How valid is the "Keratinocyte Hypothesis"?

Indian J Dermatol 2019 Jan-Feb;64(1):28-33

Department of Dermatology, IPGMER, Kolkata, West Bengal, India.

Introduction: Primary cutaneous amyloidosis (PCA) can be classified into four principal categories: macular amyloidosis, lichen amyloidosis, biphasic, and nodular amyloidosis. Some unusual variants such as widespread diffuse hyperpigmentation without papules, poikiloderma like involvement, lesions following Blaschko's line, etc., have also been reported. Read More

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February 2019

Clinical and genetic features of Chinese patients with lichen and macular primary localized cutaneous amyloidosis.

Clin Exp Dermatol 2019 Jun 7;44(4):e110-e117. Epub 2019 Feb 7.

Dermatology Hospital, Southern Medical University, Guangzhou, China.

Background: Primary localized cutaneous amyloidosis (PLCA) is a chronic pruritic skin disorder. The genetic basis of familial (f)PLCA involves mutations in the oncostatin M receptor (OSMR) and interleukin-31 receptor A (IL31RA) genes, but the disease pathophysiology is not fully understood.

Aim: To investigate the OSMR mutation spectrum in patients with sporadic (s)PLCA/fPLCA, lichen/macular PLCA in mainland China. Read More

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Long-term follow-up of RET Y791F carriers in Denmark 1994-2017: A National Cohort Study.

J Surg Oncol 2019 May 15;119(6):687-693. Epub 2019 Jan 15.

Department of ORL, Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

Background And Objectives: Recently, a comprehensive study presented evidence that a long-disputed REarranged during Transfection (RET) variant, RET Y791F, should be classified as nonpathogenic. In spite of this, several subsequently published papers, including the revised American Thyroid Association guidelines for medullary thyroid carcinoma, refer to the variant as pathogenic. This study presents data from a unique national Danish cohort of RET Y791F carriers who have been followed by watchful waiting instead of being subjected to early thyroidectomy, to determine if any carrier shows evidence of multiple endocrine neoplasia 2A (MEN2A) at long-term follow-up. Read More

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Image Gallery: Dermoscopy of lichen amyloidosis.

Br J Dermatol 2018 12;179(6):e231

Dermatology Unit, University of Campania, Nuovo Policlinico (Edificio 9C), Via Pansini 5, 80131, Naples, Italy.

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December 2018

The RET C611Y mutation causes MEN 2A and associated cutaneous

Endocr Connect 2018 Sep 1;7(9):998-1005. Epub 2018 Sep 1.

Background: Cutaneous lichen amyloidosis (CLA) has been reported in some multiple endocrine neoplasia type 2A (MEN 2A) families affected by specific germline RET mutations C634F/G/R/W/Y or V804M, as a characteristic of the clinical manifestation in ‘MEN 2A with CLA’, one of four variants of MEN 2A, which was strictly located in the scapular region of the upper back.

Patient Findings: This study reports a large south-eastern Chinese pedigree with 17 individuals carrying the MEN 2A-harboring germline C611Y (c.1832G>A) RET mutation by Sanger sequencing. Read More

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September 2018

Successful Treatment of Lichen Amyloidosis With Trichloroacetic Acid Peels.

Dermatol Surg 2019 06;45(6):854-857

Department of Dermatology, UT Houston, Houston, Texas.

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Dermoscopy of Pigmentary Disorders in Brown Skin.

Dermatol Clin 2018 Oct;36(4):473-485

Department of Dermatology, Command Hospital, 17/1E, Alipore Road, Alipore Police Line, Alipore, Kolkata, West Bengal 700027, India. Electronic address:

Dermoscopy is a noninvasive technique for the diagnosis, prognosis, and monitoring of pigmentary disorders in brown skin. It can be used for the diagnosis of various facial melanoses, which can avoid the need for biopsy in many cases. It can also help in early identification of the adverse effect of topical steroids and hydroquinone when they are used for the treatment of these disorders. Read More

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October 2018

Quality of life in patients with acquired pigmentation: An observational study.

J Cosmet Dermatol 2018 12 11;17(6):1293-1294. Epub 2018 Jul 11.

Department of Dermatology & STD, Lady Hardinge Medical College and Associated Hospital, New Delhi, India.

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December 2018

Beltlike lichen planus pigmentosus complicated with focal amyloidosis.

Cutis 2018 05;101(5):E24-E26

Department of Dermatology, First Affiliated Hospital, Nanjing Medical University, China.

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An intensely pruritic pebbled presentation.

Dermatol Online J 2018 Mar 7;24(2). Epub 2018 Mar 7.

Department of Dermatology, Barts Health NHS Trust, London, U.K.

Lichen amyloidosis (LA) is a form of primary localized cutaneous amyloidosis (PLCA) characterized by bilateral intensely itchy domed scaly hyperkeratotic papules. Lichen amyloidosis is rare and affects men more than women. It is uncommonly seen in the western world but more prevalent in Asia. Read More

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Metastatic pheochromocytoma in MEN 2A: A rare association.

BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

A 45-year-old woman was diagnosed as having multiple endocrine neoplasia type 2A in 2014. She had bilateral pheochromocytoma, medullary thyroid carcinoma and biopsy-proven cutaneous lichen amyloidosis in the interscapular area. She underwent bilateral adrenalectomy; following which, she achieved clinical and biochemical remission. Read More

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