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    342 results match your criteria Amyloidosis Lichen

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    Alitretinoin treatment of lichen amyloidosis.
    Dermatol Ther 2017 Sep 14. Epub 2017 Sep 14.
    Department of Dermatology, Hanyang University Hospital, Seoul, South Korea.
    Lichen amyloidosis (LA) is characterized by the deposition of amyloid that may respond to chronic scratching that may be secondary to atopic dermatitis, stasis dermatitis, or interface dermatitis. Despite the development of several therapeutic strategies, including topical steroids, oral antihistamines, cyclosporine, and retinoids, an effective treatment for LA has not been established. A 49-year-old woman who has been treated irregularly for atopic dermatitis for 7 years presented with localized brownish papules on the left forearm and right elbow. Read More

    Laser treatment of medical skin disease in women.
    Int J Womens Dermatol 2017 Sep 21;3(3):131-139. Epub 2017 Jul 21.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Laser treatment is a relatively new and increasingly popular modality for the treatment of many dermatologic conditions. A number of conditions that predominantly occur in women and that have a paucity of effective treatments include rosacea, connective tissue disease, melasma, nevus of Ota, lichen sclerosus (LS), notalgia paresthetica and macular amyloidosis, and syringomas. Laser therapy is an important option for the treatment of patients with these conditions. Read More

    Successful treatment of lichen amyloidosis accompanied by atopic dermatitis by fractional CO2 laser.
    J Cosmet Laser Ther 2017 Oct 23;19(6):345-346. Epub 2017 May 23.
    a Department of Dermatology , Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine , Seoul , Korea.
    Lichen amyloidosis (LA) is a subtype of primary cutaneous amyloidosis that is presented as persistent, multiple-grouped hyperkeratotic papules usually located on the shins, back, forearms or thighs. The treatment of LA has been considered to be difficult, and of the various methods available, recent studies have reported the efficacy of fractional CO2 lasers. LA may be accompanied by atopic dermatitis (AD) in which the treatment options may be more limited. Read More

    Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review.
    Am J Clin Dermatol 2017 Mar 24. Epub 2017 Mar 24.
    Department of Dermatology, University Hospital Jena, Erfurter Straße 35, Jena, 07743, Germany.
    Background: Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposition of heterogenic amyloid proteins in the skin without systemic involvement. Lichen amyloidosis, macular amyloidosis, and (primary localized cutaneous) nodular amyloidosis are different subtypes of PLCA.

    Objective: The aim of this study was to review the current reported treatment options for PLCA. Read More

    Polydactylous Transverse Erythronychia: Report of a Patient with Multiple Horizontal Red Bands Affecting the Fingernails.
    Dermatol Ther (Heidelb) 2017 Jun 4;7(2):255-262. Epub 2017 Mar 4.
    Department of Dermatology, University of California San Diego, San Diego, CA, USA.
    Introduction: Redness of the nail plate-erythronychia-is a common condition involving one or multiple digits. It may affect the entire nail or present as longitudinal red bands that extend from the proximal nail fold to the distal tip of the nail plate. Rarely, red bands may traverse the nail bed horizontally. Read More

    Primary localized cutaneous amyloidosis with lichen and poikiloderma-like lesions and an excellent response to systemic acitretin.
    An Bras Dermatol 2016 Sep-Oct;91(5):661-663
    Third Affiliated Hospital, Sun Yat-sen University - Guangdong, China.
    Primary localized cutaneous amyloidosis is a skin-limited amyloidosis that does not involve internal organs. It is clinically subclassified into 3 general categories and some rare variants. However, there is considerable overlap within the classification. Read More

    Dermoscopy in General Dermatology: A Practical Overview.
    Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

    Generation of an induced pluripotent stem cell line from a patient with hereditary multiple endocrine neoplasia 2A (MEN2A) syndrome with RET mutation.
    Stem Cell Res 2016 Jun 27;17(1):154-157. Epub 2016 Jun 27.
    INSERM U935, Université Paris Sud, 94800 Villejuif, France; ESTeam Paris Sud, INSERM U935, Université Paris Sud, Université Paris-Saclay, 94800 Villejuif, France; INGESTEM National IPSC Infrastructure, 94800 Villejuif, France; Division of Hematology, Paris Sud University hospitals, Le Kremlin Bicêtre 94275, Villejuif 94800, France. Electronic address:
    Multiple Endocrine Neoplasia Type 2A (MEN2A) is a cancer-predisposing syndrome that affects patients with germline RET mutations. The clinical spectrum of the syndrome includes medullary thyroid carcinoma (MTC), pheochromocytoma, hyperparathyroidism and cutaneous lichen amyloidosis (CLA) and/or Hirschsprung disease in some variants. Currently, there is no satisfactory animal model recapitulating all the features of the disease especially at the level of stem cells. Read More

    [Genotype-phenotype correlations in multiple endocrine neoplasia type 2].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 Jul;51(7):538-41
    Department of Head and Neck Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
    Objective: To evaluate the relationship between different RET mutations and the aggressiveness of hereditary medullary thyroid cancer (HMTC) or the presentation of other endocrine disorders in patients with multiple endocrine neoplasia type 2 (MEN2).

    Methods: A total of 73 thyroid medullary carcinoma patients from 22 Chinese kindreds who were treated in our center from 2010 to 2015 were enrolled. RET genes in the patients and their relatives were screened. Read More

    Treatment of primary cutaneous amyloidosis with laser: a review of the literature.
    Lasers Med Sci 2016 Jul 16;31(5):1027-35. Epub 2016 Mar 16.
    Department of Medicine, Division of Dermatology, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
    Primary cutaneous amyloidosis (PCA) is a condition characterized by tissue deposition of misfolded proteins. PCA can present in different forms, namely macular, lichen, and nodular amyloidosis. These lesions can be of cosmetic concern and are difficult to treat. Read More

    MEN 2A-related cutaneous lichen amyloidosis: report of three kindred and systematic literature review of clinical, biochemical and molecular characteristics.
    Fam Cancer 2016 Oct;15(4):625-33
    Thyroid Section, Endocrine Division, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre, RS, 90035-003, Brazil.
    Multiple endocrine neoplasia type 2A (MEN2A) may be rarely associated with cutaneous lichen amyloidosis (CLA), a skin lesion located in the interescapular region. Here, we describe 3 MEN2A-related CLA kindred and perform a systematic review (SR) of the literature on clinical, biochemical and molecular characteristics of MEN2A-related CLA patients. Thirty-eight patients with MEN2A-related CLA followed at our institution were evaluated. Read More

    THE AUTOIMMUNE CONSTELLATION IN LICHEN AMYLOIDOSIS.
    Rev Med Chir Soc Med Nat Iasi 2015 Oct-Dec;119(4):1045-50
    Localized cutaneous amyloidosis is a rare disease among white people, being more common in South-Asia, China and South America. The disease is characterized by deposition of amyloid material in the papillary dermis without visceral involvement. Nevertheless, there is a growing list of immune-mediated disorders that have been linked to cutaneous amyloidosis. Read More

    Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation.
    Recent Results Cancer Res 2015 ;204:139-56
    Endokrinologische Gemeinschaftspraxis, Brückenstr 21, 69120, Heidelberg, Germany.
    During the last two decades, there has been a marked expansion of our knowledge of both the basic and clinical aspects of multiple endocrine neoplasia type 2 (MEN2). There are two clinically distinct types of MEN2 syndrome, termed MEN2A and MEN2B. Within MEN2A, there are four variants: (i) classical MEN2A, represented by the uniform presence of MTC and the less frequent occurrence of pheochromocytoma, or primary hyperparathyroidism, or both; (ii) MEN2A with cutaneous lichen amyloidosis; (iii) MEN2A with Hirschsprung's disease; and (iv) familial medullary thyroid carcinoma (FMTC), i. Read More

    Nodular amyloidosis derived from keratinocytes: an unusual type of primary localized cutaneous nodular amyloidosis.
    Am J Dermatopathol 2015 Nov;37(11):e129-33
    Departments of *Pathology, and †Orthopedics, University of Massachusetts Medical School, Worcester, MA.
    Primary, localized cutaneous amyloidosis includes macular, lichen, and nodular (tumefactive) types in which the amyloid deposits are limited to the dermis without systemic involvement. The material in lichen and macular amyloidosis is derived from epidermal keratinocytes [keratinocyte-derived amyloid (AK)], whereas that in nodular amyloidosis is derived from immunoglobulin light-chains amyloid (AL). Primary, localized cutaneous nodular amyloidosis (PLCNA) is a form of primary, localized cutaneous amyloidosis that has been associated with a risk of progression to systemic amyloidosis. Read More

    Genotype-Phenotype Correlation in Indian Patients with MEN2-Associated Pheochromocytoma and Comparison of Clinico-Pathological Attributes with Apparently Sporadic Adrenal Pheochromocytoma.
    World J Surg 2016 Mar;40(3):690-6
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, India.
    Introduction: Pheochromocytoma (PCC) manifests in up to 50% of MEN2 patients. We correlated the clinico-pathological features of MEN2-associated PCC (MEN-PCC) with RET mutations and compared them with non-MEN adrenal-PCCs.

    Methods: In this retrospective single institution study on a large PCC database (n = 208, 1997-2014) 24 MEN-PCC patients with known RET mutations were reviewed. Read More

    RET mutation p.S891A in a Chinese family with familial medullary thyroid carcinoma and associated cutaneous amyloidosis binding OSMR variant p.G513D.
    Oncotarget 2015 Oct;6(32):33993-4003
    Department of Oncologic and Urology Surgery, the 117th PLA Hospital, Wenzhou Medical University, Hangzhou 310004, Zhejiang Province, China.
    There are no reports on the relationship between familial medullary thyroid carcinoma (FMTC) associated with cutaneous amyloidosis (CA) and RET or OSMR/IL31RA gene mutations. In this study, we investigated a Chinese family with FMTC/CA and found a recurrent RET c.2671T>G (p. Read More

    Efficacy of different modes of fractional CO2 laser in the treatment of primary cutaneous amyloidosis: A randomized clinical trial.
    Lasers Surg Med 2015 Jul 6;47(5):388-95. Epub 2015 May 6.
    Department of Histology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
    Background: Primary cutaneous amyloidosis (PCA) comprises three main forms: macular, lichen, and nodular amyloidosis. The current available treatments are quite disappointing.

    Objectives: Assess and compare the clinical and histological changes induced by different modes of Fractional CO2 laser in treatment of PCA. Read More

    Fractional 1,550 nm Ytterbium/Erbium fiber laser in the treatment of lichen amyloidosis: clinical and histological study.
    Lasers Surg Med 2015 Mar 13;47(3):222-30. Epub 2015 Mar 13.
    Department of Medicine, Division of Dermatology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
    Background And Objective: Lichen amyloidosis is characterized by amyloid deposition in the papillary dermis, presenting clinically with intensely pruritic hyperkeratotic papules. Various treatment modalities have been used but the results are generally unsatisfactory. Several studies show that non-ablative fractional lasers can be used to treat depositional diseases due to their capability of inducing transepidermal elimination of the dermal content. Read More

    Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations.
    Indian J Dermatol 2015 Jan-Feb;60(1):105
    Department of Pathology, J N Medical College, Belgaum, Karnataka, India.
    A 55-year-old man presented with multiple, itchy papules and macules on the trunk and extremities. Histopathologic examination of biopsy specimens taken from three different lesions showed a subepidermal blister with amyloid deposits in the dermal papillae. No systemic disease or involvement of other organs was detected. Read More

    Response to oral acitretin in lichen amyloidosis.
    Indian Dermatol Online J 2014 Dec;5(Suppl 2):S92-4
    Department of Dermatology, KJ Somaiya Medical College, Sion, Mumbai, Maharashtra, India.
    We report the therapeutically challenging case of a patient with severe and extensive lichen amyloidosis (LA) who responded to oral acitretin and topical corticosteroids. Colloid milia and terra firma-forme dermatoses were noted post healing of the lesions of LA. There has been no recurrence of lesions post 8 months of follow-up. Read More

    Oral primary localized amyloidosis in HIV-infected patients: the oral face of a described skin lesion.
    Int J STD AIDS 2015 Dec 12;26(14):1049-51. Epub 2015 Jan 12.
    Hospital Infantil de México "Federico Gómez", Mexico City, Mexico.
    Oral primary localized amyloidosis should be considered in the diagnosis of oral white lesions such as hyperplastic candidosis, lichen planus and lichenoid reactions; it is not associated with antiretroviral therapy use, systemic involvement or malignant transformation. Read More

    Epidermolysis bullosa pruriginosa: a case with a novel mutation and co-existent lichen amyloidosus.
    Indian J Dermatol Venereol Leprol 2015 Jan-Feb;81(1):40-2
    National Skin Centre, 1 Mandalay Road, Singapore.
    Epidermolysis bullosa pruriginosa is a rare variant of dystrophic epidermolysis bullosa characterized by severely pruritic and cicatricial lesions localized to the extensor extremities. We report a Singaporean Chinese male with epidermolysis bullosa pruriginosa with an underlying novel mutation in the COL7A1 gene. A heterozygous acceptor splice site mutation IVS67-1G>T probably led to in-frame skipping of exon 68 (36-basepairs), resulting in a loss of 12 amino acids. Read More

    An alternative treatment model: the combination therapy of narrow band ultraviolet B phototherapy and tacrolimus ointment 0.1% in biphasic amyloidosis.
    J Pak Med Assoc 2014 May;64(5):579-82
    Primary localized cutaneous amyloidosis (PLCA) is caused by the extracellular deposition of amyloid material in the skin without other cutaneous or systemic organ involvement. PCLA is classified into lichen, macular,and nodular amyloidosis. Macular amyloidosis and lichen amyloidosis are named as biphasic amyloidosis when they are concurrently seen in a patient. Read More

    Localized amyloidosis of the vulva with and without vulvar intraepithelial neoplasia: report of a series.
    Hum Pathol 2014 Oct 23;45(10):2037-42. Epub 2014 Jul 23.
    Department of Pathology and Laboratory Medicine, Women and Infants Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02905.
    Localized primary cutaneous amyloidosis is uncommon in Europe and North America and is infrequently reported in the English literature. The constituents of such deposits have not been previously examined; this series characterizes amyloid deposits in localized vulvar amyloidosis and their association with vulvar intraepithelial neoplasia. All biopsies and excisions of vulva over 18 months were reviewed. Read More

    [Skin disorders associated with monoclonal gammopathies].
    Ned Tijdschr Geneeskd 2014 ;158:A6717
    Leids Universitair Medisch Centrum, Leiden.
    A monoclonal gammopathy is a condition in which a monoclonal immunoglobulin (M-protein, formerly known as paraprotein) produced by a clonal proliferation of plasma cells is present in the blood. The spectrum of monoclonal gammopathies includes monoclonal gammopathy of uncertain significance (MGUS), multiple myeloma, Waldenström disease, plasmacytoma and primary amyloidosis. Various skin diseases are associated with monoclonal gammopathies. Read More

    Successful treatment of lichen amyloidosis using a CO2 surgical laser.
    Dermatol Ther 2014 Mar-Apr;27(2):71-3. Epub 2013 May 2.
    Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
    Lichen amyloidosis (LA) is a type of primary localized cutaneous amyloidosis characterized by multiple pruritic discrete hyperkeratotic papules with amyloid deposition in the papillary dermis. Two patients with LA had been treated with topical corticosteroids, but with no effect on the eruptions. The present authors then started treating the affected area by superficial ablation using a CO2 surgical laser (LASER 30C, Lumenis Inc. Read More

    A Th2 cytokine interleukin-31 signature in a case of sporadic lichen amyloidosis.
    Acta Derm Venereol 2015 Feb;95(2):223-4
    Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin disorders, Hôpital Sain-André, 1 rue Jean Burguet, FR-33075 Bordeaux, France.

    Itch in familial lichen amyloidosis: effective treatment with amitriptyline in two cases.
    Dermatol Ther 2014 Jan-Feb;27(1):12-5. Epub 2013 Mar 25.
    National Skin Centre, Singapore.
    Itch is a characteristic feature of lichen amyloidosis and the symptom can be debilitating. Treatments, however, are generally not effective. We report amitriptyline as a novel therapy in treating itch in two patients with familial lichen amyloidosis who did not respond to prior potent topical corticosteroids and antihistamines. Read More

    Epidermolysis bullosa pruriginosa affecting 3 successive generations.
    Skinmed 2013 Sep-Oct;11(5):308-9
    Department of Dermatology, Katihar Medical College, Katihar, India.
    A 24-year-old man presented with multiple mildly itchy flesh-colored papules and plaques on both legs for the past decade. The lesions were preceded by transient vesicles that contained clear fluid. The papules and plaques used to develop on sites where vesicles had healed. Read More

    Reactive eccrine syringofibroadenomatosis secondary to primary cutaneous amyloidosis: a novel association.
    J Cutan Pathol 2014 Apr 30;41(4):380-5. Epub 2014 Jan 30.
    Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
    We report the unprecedented case of reactive eccrine syringofibroadenoma (ESFA) secondary to primary cutaneous amyloidosis. A 62-year-old woman of Asian ethnicity presented with a pruritic rash on the back of long-standing duration. Physical examination revealed diffuse hyperpigmentation localized to the interscapular region; there were a multitude of hyperpigmented macules merged in a rippled pattern intermixed with scattered papules and cobblestone-like areas. Read More

    Generalized lichen amyloidosis and hyperthyroidism: coincidence or association.
    Postepy Dermatol Alergol 2013 Aug 27;30(4):265-7. Epub 2013 Aug 27.
    Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey. Head: Prof. Dr. Nurettin Karaoğlanoğlu.
    A 76-year-old white man presented with severe pruritic eruption on both of the extremities and lumbar area for 2 years. The dermatological examination showed multiple, 1-2 mm sized, hyperpigmented and hyperkeratotic papules which coalesced to form poorly delineated plaques spread on the lumbosacral area, lateral and extensor surfaces of thighs, arms and forearms. The histopathological examination revealed eosinophilic amorphous material in papillary dermis that was stained positively with crystal violet stain. Read More

    A generalized, non-pruritic variant of lichen amyloidosis: a case report and a brief review.
    Indian J Dermatol 2013 Jul;58(4):328
    Department of Dermatology and STD, Safdarjung Hospital, New Delhi, India.
    Lichen amyloidosis (LA) has been considered a highly pruritic dermatosis, and the deposition of fibrillar material has generally been considered to be secondary to the scratching. Focal epidermal damage and chronic scratching have been implicated as the pathogenetic factors in the occurrence of LA, although they may not be able to explain the occurrence of a widespread variant of this dermatosis. There are few case reports describing the occurrence of a non-pruritic variant of LA. Read More

    Clinicopathological correlation of acquired hyperpigmentary disorders.
    Indian J Dermatol Venereol Leprol 2013 May-Jun;79(3):367-75
    Department of Dermatology, Oregon Health Sciences University, Portland, Oregon, USA.
    Acquired pigmentary disorders are group of heterogenous entities that share single, most significant, clinical feature, that is, dyspigmentation. Asians and Indians, in particular, are mostly affected. Although the classic morphologies and common treatment options of these conditions have been reviewed in the global dermatology literature, the value of histpathological evaluation has not been thoroughly explored. Read More

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