J Biol Chem 2021 Jan 25:100333. Epub 2021 Jan 25.
Department of Biotechnology, Faculty of Biology-oriented Science and Technology, Kindai University, Wakayama 649-6493, Japan.
β2-Microglobulin (β2m) is the causative protein of dialysis-related amyloidosis. Its unfolding mainly proceeds along the pathway of N →U ⇄ U, whereas refolding follows the U → I (→N) →N pathway, in which N, I, and U are the native, intermediate, and unfolded states, respectively, with the Pro32 peptidyl-prolyl bond in cis or trans conformation as indicated by the subscript. It is noted that the I state is a putative amyloidogenic precursor state. Read More