3,453 results match your criteria Ampullary Carcinoma


Percutaneous transhepatic cholangial drainage combined with percutaneous endoscopic jejunostomy for maintaining nutrition state in patients with advanced ampullary neoplasms.

J Cancer Res Ther 2018 Dec;14(Supplement):S1158-S1162

Department of General Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan, China.

Purpose: To investigate the role of percutaneous transhepatic cholangial drainage (PTCD) combined with percutaneous endoscopic jejunostomy (PEJ) in maintaining the nutrition state in patients with advanced ampullary neoplasms.

Materials And Methods: Sixty patients who suffered from advanced ampullary neoplasms and could not tolerate internal drainage operation or biliary stent placement were enrolled. After PTCD, PEJ was implemented, and then the enteral nutrient solution + bile were instilled through PEJ tube for enteral nutrition support. Read More

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December 2018

Brain metastasis and herniation in a patient with ampullary adenocarcinoma presenting with jaundice and memory loss: case report.

J Gastrointest Oncol 2018 Oct;9(5):871-874

Multiple Organ Transplant Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Periampullary carcinoma includes neoplasms arising from head of pancreas, distal common bile duct, duodenum and ampulla of Vater. We report a case of a 41-year-old male, medically free who presented to our hospital as a case of obstructive jaundice, weight loss, headache and blurred vision. Clinical evaluation revealed memory loss and ataxia. Read More

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October 2018
2 Reads

KRAS, NRAS and BRAF analysis of ampullary adenocarcinoma classified using CK7, CK20, MUC1 and MUC2.

J Gastrointest Oncol 2018 Oct;9(5):820-827

Pathology Department, Habib Thameur Hospital, Tunis, Tunisia.

Background: Ampullary carcinomas are rare and dominated by adenocarcinomas. They account for only 0.5% of all gastrointestinal malignancies. Read More

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October 2018

Demographics, tumor characteristics, treatment, and clinical outcomes of patients with ampullary cancer: a surveillance, epidemiology, and end results (SEER) cohort study.

Minerva Gastroenterol Dietol 2018 Nov 27. Epub 2018 Nov 27.

Division of Gastroenterology and Hepatology, School of Medicine Huntsman Cancer Center, University of Utah, Salt Lake City, UT, USA -

Introduction: Ampullary cancer accounts for only 0.2% of GI cancers. The objective of this study was to investigate the incidence, demographics, tumor characteristics, treatment, and survival of patients with ampullary tumors. Read More

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November 2018
1 Read

Ampulla of Vater carcinoma: Molecular landscape and clinical implications.

World J Gastrointest Oncol 2018 Nov;10(11):370-380

Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona 37134, Italy.

Ampulla of Vater is a peculiar anatomical structure, characterized by the crossroad of three distinct epithelia: Intestinal, ductal pancreatic and biliary. Adenocarcinomas arising in this area represent an opportunity to understand the comparative biology of all periampullary malignancies. These neoplasms can exhibit intestinal, pancreaticobiliary or mixed features, whereas the subclassification based on morphology and immunohistochemical features failed in demonstrating a robust prognostic reliability. Read More

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November 2018

Laparoscopic transduodenal ampullectomy for ampullary tumor.

Cir Esp 2018 Nov 24. Epub 2018 Nov 24.

Unidad de Cirugía de Hepatobiliopancreática, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, España.

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November 2018

Endoscopic radiofrequency biliary ablation treatment: a comprehensive review.

Dig Endosc 2018 Nov 16. Epub 2018 Nov 16.

Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University, Rome, Italy.

Radiofrequency ablation (RFA) acts by delivering thermal energy within the tissue, the result of a high-frequency alternating current released from an active electrode, leading to coagulative necrosis and cellular death. Recently, a biliary catheter working on a guide-wire has been developed and a number of studies have been performed so far. The present paper provides a comprehensive review of the literature on the results of the use of RFA for the clinical management of patients with unresectable malignant biliary strictures, benign biliary strictures, and residual adenomatous tissue in the bile duct after endoscopic papillectomy. Read More

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November 2018
7 Reads

New experience of endoscopic papillectomy for ampullary neoplasms.

Surg Endosc 2018 Nov 12. Epub 2018 Nov 12.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 28#, Fuxing Road, Beijing, 100853, China.

Aim: To establish the clinical value of endoscopic papillectomy for duodenal papillary tumor based on endoscopic and clinical characteristics.

Patients And Methods: This single-center, retrospective study included 110 patients with duodenal papillary tumor who underwent endoscopic papillectomy between January 2006 and April 2017 at the gastrointestinal endoscopic center of the Chinese PLA General Hospital. Clinical data, postoperative pathology, procedure-related complications, and therapeutic outcomes were analyzed. Read More

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November 2018
6 Reads

How to Approach a Patient With Ampullary Lesion.

Gastroenterology 2018 12 9;155(6):1670-1676. Epub 2018 Nov 9.

Department of Internal Medicine, Evangelisches Krankenhaus Düsseldorf, Düsseldorf, Germany.

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December 2018

Heterotopic Quadruplet Pregnancy After ICSI Conception.

J Obstet Gynaecol India 2018 Dec 12;68(6):505-507. Epub 2017 Sep 12.

Department of Obstetrics and Gynecology, KEM Hospital, Pune, India.

Background: Heterotopic pregnancy (HP) is a condition characterized by the coexistence of multiple fetuses at two or more implantation sites. It occurs in 1% of pregnancies after assisted reproductive techniques (ART). Presence of triplet intrauterine pregnancy with ectopic gestational sac is one of the rarest forms of HP. Read More

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December 2018
3 Reads

Predictors of Recurrent Biliary Obstruction Following Percutaneous Uncovered Metal Stent Insertion in Patients with Distal Malignant Biliary Obstruction: An Analysis Using a Competing Risk Model.

Cardiovasc Intervent Radiol 2018 Nov 8. Epub 2018 Nov 8.

Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.

Objective: To evaluate predictive factors of recurrent biliary obstruction (RBO) following percutaneous uncovered metal stent placement for unresectable distal malignant biliary obstruction (MBO) by using a competing risk model.

Materials And Methods: Between March 2012 and March 2016, 119 patients underwent percutaneous uncovered metal stent placement with distal MBO at our institution. Univariate and multivariate analyses were conducted to identify the prognostic factors for RBO using a competing risk model. Read More

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November 2018
6 Reads

Peroral cholangioscopy by SpyGlass DS versus CHF-B260 for evaluation of the lateral spread of extrahepatic cholangiocarcinoma.

Endosc Int Open 2018 Nov 7;6(11):E1349-E1354. Epub 2018 Nov 7.

Sendai City Medical Center - Gastroenterology, Sendai, Japan.

 A newly developed peroral cholangioscopy (POCS) system, SpyGlassDS has high maneuverability. This study aimed to evaluate acceptability of the accuracy of SpyGlassDS accompanied by simultaneous POCS-guided biopsy compared with that of a traditional POCS scope, CHF-B260, to diagnose the lateral extent of extrahepatic cholangiocarcinoma (LEC).  Patients who underwent surgical resection after preoperative examinations to diagnose LEC were evaluated. Read More

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November 2018
4 Reads

Prognostic Role of Lymph Node Positivity and Number of Lymph Nodes Needed for Accurately Staging Small Bowel Neuroendocrine Tumors.

JAMA Surg 2018 Oct 31. Epub 2018 Oct 31.

Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Importance: Little information is available regarding the minimum number of lymph nodes needed to accurately stage patients when performing a mesenteric lymphadenectomy for small-bowel neuroendocrine tumors.

Objectives: To determine the prognostic role of lymph node positivity and the ideal number of lymph nodes for accurately staging patients with small-bowel neuroendocrine tumors.

Design, Setting, And Participants: This case series from the US Neuroendocrine Tumor Study Group, a collaboration among 8 US-based, academic tertiary care referral centers, obtained demographic, perioperative, and pathologic data from the group's database, Social Security Death Index, and publicly available obituaries. Read More

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October 2018
4 Reads

The HER3 pathway as a potential target for inhibition in patients with biliary tract cancers.

PLoS One 2018 18;13(10):e0206007. Epub 2018 Oct 18.

Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

Introduction: Expression of human epidermal growth factor receptor (HER)2 and HER3 have been investigated in small BTC studies using variable scoring systems.

Methods: HER2 and HER3 overexpression/amplification were explored following internationally agreed guidelines using immunohistochemistry (IHC) and fluorescent in-situ hybridisation (FISH), respectively. Logistic regression and survival analysis (Kaplan Meier, Log rank test and Cox Regression) were used for statistical analysis. Read More

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October 2018
5 Reads

Methylated promoter DNA of CDO1 gene and preoperative serum CA19-9 are prognostic biomarkers in primary extrahepatic cholangiocarcinoma.

PLoS One 2018 16;13(10):e0205864. Epub 2018 Oct 16.

Department of Surgery, Kitasato University Hospital, Kitasato, Minami-ku, Sagamihara, Kanagawa, Japan.

Background: Promoter DNA methylation of Cysteine dioxygenase type1 (CDO1) gene has been clarified as a molecular diagnostic and prognostic indicator in various human cancers. The aim of this study is to investigate the clinical relevance of CDO1 methylation in primary biliary tract cancer (BTC).

Methods: CDO1 DNA methylation was assessed by quantitative methylation-specific PCR in 108 BTC tumor tissues and 101 corresponding normal tissues. Read More

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October 2018
2 Reads

Endoscopic diagnosis and treatment of superficial non-ampullary duodenal tumors.

World J Gastrointest Endosc 2018 Sep;10(9):156-164

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo 1018309, Japan.

The diagnostic and treatment guidelines of superficial non-ampullary duodenal tumors have not been standardized due to their low prevalence. Previous reports suggested that a superficial adenocarcinoma (SAC) should be treated local resection because of its low risk of lymph node metastasis, whereas a high-grade adenoma (HGA) should be resected because of its high risk of progression to adenocarcinoma. Therefore, pretreatment diagnosis of SAC or HGA is important to determine the appropriate treatment strategy. Read More

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September 2018
1 Read

Magnetic compression anastomosis for biliojejunostomy and pancreaticojejunostomy in Whipple's procedure: An initial clinical study.

J Gastroenterol Hepatol 2018 Oct 2. Epub 2018 Oct 2.

Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background And Aim: Magnetic anastomosis has been attempted in biliary and intestinal reconstruction. The objective of the current study was to introduce an initial clinical use of magnetic compression anastomosis for pancreaticojejunostomy and biliojejunostomy in Whipple's procedure.

Methods: Patients with peri-ampullary carcinoma and dilated bile and pancreatic ducts were prospectively enrolled from 2016 to 2017. Read More

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October 2018
1 Read

[Prognostic factors in adenocarcinoma of the ampulla of Vater].

Rev Esp Patol 2018 Oct - Dec;51(4):210-215. Epub 2018 Apr 13.

Departamentos de Anatomía Patológica y Cirugía General, Hospital Clínico San Carlos, Madrid, España.

Introduction: Ampullary adenocarcinoma seems less aggressive than other pancreato-biliary neoplasms. The aim of this study is to define determining prognostic factors.

Material And Methods: Retrospective case series from a large tertiary Hospital including all patients diagnosed with ampullary adenocarcinoma who underwent cephalic pancreatoduodenectomy with curative intent. Read More

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April 2018
2 Reads

Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer.

Pancreatology 2018 Dec 25;18(8):977-982. Epub 2018 Sep 25.

First Department of Surgery, Jagiellonian University Medical College, Krakow, Poland. Electronic address:

Background: Aberrantly expressed mucin glycoproteins (MUC) play important roles in pancreatic ductal adenocarcinoma (PDAC), yet their use as a diagnostic aid in fine-needle aspiration biopsy (FNAB) is poorly documented. The aim of this study was to investigate the rationale and feasibility of mucin (MUC1, MUC2, MUC3, MUC4, MUC5AC, and MUC6) expression profiling by RT-PCR for diagnostic applications in cytology.

Methods: Mucin expression was examined by RT-PCR and immunohistochemistry in specimens resected from patients with pancreatic (n = 101), ampullary (n = 23), and common bile duct (n = 10) cancers and 33 with chronic pancreatitis. Read More

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December 2018
10 Reads

High-grade precursor lesions can be used as surrogate markers to identify the epicenter of periampullary carcinomas.

Hum Pathol 2018 Sep 24. Epub 2018 Sep 24.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Identifying the accurate origin of periampullary cancers is important, because different origins may trigger different clinicopathologic behaviors. The presence of intraepithelial precursor lesions, including high-grade pancreatic intraepithelial neoplasias (PanINs) and/or high-grade biliary intraepithelial neoplasias (BilINs), may be suggestive of the origin of the periampullary carcinoma in challenging cases. To prove the usefulness of high-grade intraepithelial precursor lesions to identify the origin of ambiguous periampullary cancers, the status and grades of PanINs and BilINs were evaluated in 256 periampullary carcinomas with a well-defined cancer origin as a test set, including 114 pancreatic cancers, 82 distal bile duct cancers, 54 ampullary cancers, and 6 duodenal cancers, and 112 periampullary carcinomas with clinically equivocal epicenter either by radiologic imaging used as a validation set. Read More

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September 2018
11 Reads
2.770 Impact Factor

Superficial non-ampullary duodenal cancer identified by small-bowel capsule endoscopy: a case report (with video).

Clin J Gastroenterol 2018 Sep 26. Epub 2018 Sep 26.

Second Department of Internal Medicine, Osaka Medical College, Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.

Herein, we report for the first time a case of a surficial superficial non-ampullary duodenal cancer causing obscure intestinal bleeding that was identified by small-bowel capsule endoscopy and treated by endoscopic mucosal resection. A 73-year-old man underwent upper gastrointestinal endoscopy to identify the cause of anemia. Although conventional duodenoscopy revealed a flat, elevated 5-mm lesion with a central recess and "milk-white mucosa" at the inferior duodenal angulus, capsule endoscopy revealed a white nodular 5-mm lesion with central recess at the duodenum slightly to the anal side from the major duodenal papilla. Read More

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September 2018
1 Read

Genetic Alterations of Periampullary and Pancreatic Ductal Adenocarcinoma: An Overview.

Curr Genomics 2018 Sep;19(6):444-463

1Human Genetics Unit, Indian Statistical Institute, 203 B.T. Road, Kolkata 700108, West Bengal, India; 2Medical College and Hospital, 88, College Street, Kolkata 700073, West Bengal, India; 3Tata Memorial Centre, Mumbai400012, India; 4Tata Medical Center, Newtown, Rajarhat, 700156, Kolkata, West Bengal, India.

Pancreatic Ductal AdenoCarcinoma (PDAC) is one of the most lethal malignancies of all solid cancers. Precancerous lesions for PDAC include PanIN, IPMNs and MCNs. PDAC has a poor prognosis with a 5-year survival of approximately 6%. Read More

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September 2018
1 Read

'Bleeding Dilemma': The Story of a Periampullary Mass.

Cureus 2018 Jul 23;10(7):e3035. Epub 2018 Jul 23.

UAB Medicine, Huntsville Regional Medical Campus, Huntsville Hospital, Huntsville, USA.

Periampullary malignancies arise in the vicinity of the ampulla of Vater, a common passage for biliary and pancreatic secretions. Determining the anatomical origin of these tumors represents a diagnostic challenge. This is especially true for large tumors due to the transitional nature of this region, proximity to different structures, anatomical variations, and overlapping features among constituting structures. Read More

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July 2018
11 Reads

Preoperative platelet-lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy.

Oncol Lett 2018 Oct 8;16(4):4879-4888. Epub 2018 Aug 8.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100730, P.R. China.

The objective of the present study was to evaluate whether preoperative platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) could predict the prognosis for curative resected ampullary carcinoma. A total of 94 patients were retrospectively included over a 6-year period in which consecutive cases underwent pancreaticoduodenectomy for ampullary malignancy. Preoperative blood results were available in the 94 cases of resected ampullary carcinoma. Read More

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October 2018
1 Read

Neutrophil-to-lymphocyte ratio as a predictor of postoperative morbidity in patients with distal cholangiocarcinoma.

Mol Clin Oncol 2018 Oct 14;9(4):362-368. Epub 2018 Aug 14.

Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.

Systemic inflammatory-, immunological- and nutritional-based indices, such as the neutrophil-to-lymphocyte ratio (NLR), the prognostic nutritional index (PNI) and the Glasgow prognostic score (GPS), are drawing considerable research attention to predict the long-term prognosis of many types of cancer. Recently, these parameters have also been reported to be useful in predicting postoperative morbidity in several fields, including colorectal and otolaryngological cancer. However, while distal cholangiocarcinoma exhibits a high morbidity rate, its risk factors of morbidity have not yet been established. Read More

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October 2018
1 Read

Recurrent Acute Pancreatitis: Current Concepts in the Diagnosis and Management.

Curr Treat Options Gastroenterol 2018 Dec;16(4):449-465

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.

Purpose Of Review: There have been significant developments in the diagnosis, clinical approach, and management of patients with recurrent acute pancreatitis (RAP) in the last decade. This review systematically summarizes our current understanding of RAP.

New Findings: Gallstones and alcohol are common causes of RAP. Read More

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December 2018
2 Reads

Biliary Tract Cancer: State of the Art and potential role of DNA Damage Repair.

Cancer Treat Rev 2018 Nov 8;70:168-177. Epub 2018 Sep 8.

Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Biliary tract cancers (BTCs), including cholangiocarcinoma, gallbladder cancer and ampullary cancers, are poor-prognosis malignancies. Most patients are diagnosed with advanced disease, when treatment is limited to palliative chemotherapy. First line chemotherapy is usually administered in the form of cisplatin and gemcitabine. Read More

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November 2018
1 Read

Model-Based Vestibular Afferent Stimulation: Evaluating Selective Electrode Locations and Stimulation Waveform Shapes.

Front Neurosci 2018 30;12:588. Epub 2018 Aug 30.

Department for Biomedical Computer Science and Mechatronics, Institute of Electrical and Biomedical Engineering, UMIT-Private University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria.

A dysfunctional vestibular system can be a severe detriment to the quality of life of a patient. Recent studies have shown the feasibility for a vestibular implant to restore rotational sensation via electrical stimulation of vestibular ampullary nerves. However, the optimal stimulation site for selective elicitation of the desired nerve is still unknown. Read More

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August 2018
1 Read

Pancreatic Panniculitis: A Series of 4 Cases Associated With Pancreatic and Ampullary Disease.

Pancreas 2018 Oct;47(9):e62-e64

Department of Hepatopancreatobiliary Surgery, Royal Adelaide Hospital, Adelaide, Australia Dermatology Unit, Royal Adelaide Hospital, Adelaide, Australia SA Pathology, Adelaide, Australia Dermatology Unit, Royal Adelaide Hospital, Adelaide, Australia Department of Hepatopancreatobiliary Surgery, Royal Adelaide Hospital, Adelaide, Australia.

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October 2018

Clinicopathological Stratification and Long-term Follow-up of Patients with Periampullary Carcinomas.

Anticancer Res 2018 Sep;38(9):5379-5386

Department of Surgery, Charité University of Medicine Berlin, Berlin, Germany.

Background: Periampullary carcinomas generally confer a poor outcome. Choosing the most effective treatment regimen for each sub-entity proves challenging and is usually based on experience from pancreatic adenocarcinoma (PDAC).

Patients And Methods: The long-term follow-up is presented of 472 patients with periampullary tumors [PDAC, distal cholangiocarcinoma (dCC) and ampullary carcinomas (AC)] who underwent radical resection considering clinical characteristics, paraclinical findings and histopathological features in order to define factors of prognostic relevance. Read More

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September 2018
1 Read

Periampullary Neuroendocrine Tumor as a Cause of Acute Pancreatitis.

Am J Case Rep 2018 Sep 5;19:1063-1067. Epub 2018 Sep 5.

Department of Surgery, Mount Lebanon Hospital, Beirut, Lebanon.

BACKGROUND Duodenal and ampullary carcinoids are very rare tumors accounting respectively for 2% and 0.03% of all carcinoid tumors. Clinical findings vary according to the location of the tumor within the periampullary region; with epigastric pain being the most common presenting symptom in duodenal carcinoids and jaundice the most common clinical finding in ampullary carcinoids. Read More

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September 2018
11 Reads

Clinicopathological features related to survival in adenocarcinoma of the vaterian system in a Mexican population.

Hum Pathol 2018 Sep 1. Epub 2018 Sep 1.

Basic Research Division, Instituto Nacional de Cancerología, Mexico.

Adenocarcinomas of the ampulla of Vater account for 0.5% of malignant neoplasms of the gastrointestinal tract, and 6-20% of malignant periampullary neoplasms, the majority of patients being candidates to elective surgery. Our objective was to evaluate the clinicopathological prognostic factors of ampullary adenocarcinomas after surgical resection, in the Mexican population. Read More

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September 2018

Endoscopic resection of advanced ampullary adenomas: a single-center 14-year retrospective cohort study.

Surg Endosc 2018 Aug 23. Epub 2018 Aug 23.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Postbus 2040, 3000 CA, Rotterdam, The Netherlands.

Background: Endoscopic ampullectomy has been recognized as a safe and reliable means to resect selective tumors of the ampulla of Vater and is associated with lower morbidity and mortality rates compared to surgical resection. Success rates range from 42 to 92%, with recurrences reported in up to 33%. Studies on endoscopic resection of advanced lesions such as those with intraductal extension of adenoma (IEA) and lateral spreading adenomas (LSA) are limited. Read More

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Expanding the indication of endoscopic papillectomy for T1a ampullary carcinoma.

Dig Endosc 2018 Aug 30. Epub 2018 Aug 30.

Third Department of Surgery, Tokyo Medical University, Tokyo, Japan.

Background And Aim: Endoscopic papillectomy (EP) has been attempted not only for benign lesions but also for early ampullary carcinoma (AC). However, there is still no sufficient evidence or consensus regarding the effectiveness of EP for early AC. Herein, we evaluated the expanding indication of EP for early AC. Read More

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August 2018
8 Reads

Case series of papillectomy by endoscopic retrograde cholangiopancreatography (ERCP).

Med J Islam Repub Iran 2018 30;32:43. Epub 2018 May 30.

GI Ward, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Ampullary neoplasms are one of the causes of obstructive jaundice. Endoscopic retrograde cholangiopancreatography (ERCP) is useful procedure for diagnosing and tissue sampling of ampullary neoplasms. Ampullectomy by resecting entire ampulla provides whole lesion for pathologic evaluation and also is appropriate for real pathologic staging for further management decision but ampullectomy considered as a heroic endoscopic procedure. Read More

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May 2018
12 Reads

Biliary complications after liver transplantation: Assessment with MR cholangiopancreatography and MR imaging at 3T device.

Eur J Radiol 2018 Sep 11;106:46-55. Epub 2018 Jul 11.

Department of Diagnostic Imaging - Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy.

Purpose: Our study was aimed to assess the diagnostic value of MR cholangiopancreatography (MRCP) and MR imaging at 3 T device when evaluating biliary adverse events after liver transplantation.

Materials And Methods: A series of 384 MR examinations in 232 liver transplant subjects with suspected biliary complications (impaired liver function tests and/or biliary abnormalities on ultrasound) were performed at 3 T device (GE-DISCOVERY MR750; GE Healthcare). After the acquisition of axial 3D dual-echo T1-weighted images and T2-weighted sequences (propeller and SS-FSE), MRCP was performed through coronal thin-slab 3D-FRFSE and coronal oblique thick-slab SSFSE T2w sequences. Read More

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September 2018
7 Reads

AIDS Cholangiopathy Secondary to Cytomegalovirus as Possible Unmasking Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Individual: Case Report and Review of the Literature.

Case Rep Infect Dis 2018 26;2018:1891030. Epub 2018 Jul 26.

Department of Internal Medicine, Poona Hospital and Research Centre, Pune, India.

We present the first case report of cytomegalovirus (CMV) cholangiopathy as possible immune reconstitution inflammatory syndrome (IRIS) in a human immunodeficiency virus (HIV)-infected individual, within two months of starting effective HAART. The patient presented with abdominal pain, nausea, vomiting, decreased appetite, and jaundice. The patient was diagnosed on ERCP as AIDS cholangiopathy, and biopsy of the ampulla showed acute inflammation with CMV inclusion bodies. Read More

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July 2018
7 Reads

[Histopathology and clinical aspects of extrauterine pregnancy].

Pathologe 2018 Sep;39(5):431-444

Klinik und Poliklinik für Frauenheilkunde, Klinikums rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Deutschland.

Ectopic pregnancies are the main sources of pregnancy-related morbidity and mortality in the first trimester. They are usually located in the ampullary part of the fallopian tube and the incidence increases in the setting of assisted reproductive techniques, older age at the time of the first pregnancy, and prior adnexal procedures. The clinical aspects and diagnostic challenges of an ectopic pregnancy for the pathologist are to be outlined. Read More

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September 2018
8 Reads

Predictors of long-term survival after pancreaticoduodenectomy for peri-ampullary adenocarcinoma: A retrospective study of 5-year survivors.

Hepatobiliary Pancreat Dis Int 2018 Oct 7;17(5):443-449. Epub 2018 Aug 7.

Gastroenterology Surgical Center, Mansoura University, Mansoura 35516, Egypt.

Background: Pancreaticoduodenectomy (PD) is the standard curative treatment for periampullary tumors. The aim of this study is to report the incidence and predictors of long-term survival (≥ 5 years) after PD.

Methods: This study included patients who underwent PD for pathologically proven periampullary adenocarcinomas. Read More

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October 2018
2 Reads

Self-expandable metal stents for choledocholithiasis in Billroth II gastrectomy patients.

Hepatobiliary Pancreat Dis Int 2018 Dec 7;17(6):546-552. Epub 2018 Aug 7.

Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Hospital, 42, Jaebong-ro, Dong-Ku, Gwangju 61482, Korea.

Background: Efficient ampullary intervention is essential for endoscopic retrograde cholangiopancreatography (ERCP) in patients with a prior Billroth II gastrectomy. We retrospectively evaluated the safety and effectiveness of ampullary intervention using fully covered self-expandable metal stents (FCSEMSs) for the management of common bile duct (CBD) stones in a subset of patients with a history of Billroth II gastrectomy.

Methods: This retrospective analysis involved patients with a prior Billroth II gastrectomy who underwent ampullary intervention with FCSEMSs for the management of CBD stones. Read More

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December 2018

[Ampulloma treatment with Whipple surgery. First case report in the regional hospital of Tumbes].

Rev Gastroenterol Peru 2018 Apr-Jun;38(2):187-191

Hospital Regional de Tumbes. Tumbes, Perú.

To report the first case of Whipple surgery performed at the Regional Hospital of Tumbes for the treatment of ampullary adenocarcinoma with successful results. A case report of a patient with diagnosis of ampullary adenocarcinoma, in whom was performed the first Whipple surgery at the Regional Hospital of Tumbes, in October, 2014. The patient diagnosed with an obstructive jaundice syndrome due to ampullary adenocarcinoma underwent Whipple surgery. Read More

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August 2018
1 Read

Tumour origin and R1 rates in pancreatic resections: towards consilience in pathology reporting.

Virchows Arch 2018 09 8;473(3):293-303. Epub 2018 Aug 8.

Department of Surgical Oncology, Tata Memorial Centre, Mumbai, India.

To evaluate differences in the R1 rates of ampullary (AC), pancreatic (PC), and distal bile duct (DBD) cancers in pancreatoduodenectomies (PD) using standardised pathology assessment. Data of PD (2010-2011) analysed in accordance with the Royal College of Pathologists (UK) protocol, were retrieved. Clinicopathologic features, including frequency, topography, and mode of margin involvement in AC (n = 87), PC (n = 18), and DBD (n = 5) cancers were evaluated. Read More

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September 2018
14 Reads

A Case of Obstructive Jaundice Caused by Metastasis of Ovarian Cancer to the Duodenal Major Papilla.

Clin Med Insights Case Rep 2018 3;11:1179547618791571. Epub 2018 Aug 3.

Department of Pathology, Aizu Medical Center, Fukushima Medical University, Fukushima, Japan.

Ovarian cancer often occurs distant metastasis to the peritoneum, liver, lungs, and lymph nodes. However, there has been no reported case of direct metastasis to the duodenal major papilla. We herein reported 72-year-old woman with history of ovarian cancer surgery 11 years ago presenting with obstructive jaundice. Read More

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August 2018
6 Reads

Underutilization of Surgery in Periampullary Cancer Treatment.

J Gastrointest Surg 2018 Aug 7. Epub 2018 Aug 7.

Department of Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Background: Site-specific outcomes of resection for periampullary cancer have not been analyzed on a large, registry-based scale.

Methods: We assessed data on periampullary cancers from the SEER database. Site- and stage-specific outcomes were analyzed. Read More

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August 2018
11 Reads
2.800 Impact Factor

Comparative analysis of ESD versus EMR in a large European series of non-ampullary superficial duodenal tumors.

Endosc Int Open 2018 Aug 3;6(8):E1008-E1014. Epub 2018 Aug 3.

Department of Hepato-Gastroenterology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Background And Study Aims : The choice of endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) in non-ampullary superficial duodenal tumors (NASDTs) is challenging and the benefits of ESD remain unclear. The aim was to comparatively analyze the feasibility, outcomes and safety of these techniques in these lesions.

Patients And Methods:  This is an observational and retrospective study. Read More

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August 2018
3 Reads

ESD versus EMR in non-ampullary superficial duodenal tumors: a systematic review and meta-analysis.

Endosc Int Open 2018 Aug 3;6(8):E998-E1007. Epub 2018 Aug 3.

Department of Hepato-Gastroenterology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Background And Study Aims:  Endoscopic submucosal dissection (ESD) has been developed as an option for treatment of esophageal, gastric and colorectal lesions. However, there is no consensus on the role of ESD in duodenal tumors.

Methods:  This systematic review and meta-analysis compared ESD and endoscopic mucosal resection (EMR) in sporadic non-ampullary superficial duodenal tumors (NASDTs), including local experience. Read More

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August 2018
2 Reads

Pancreatic and bile duct cancer circulating tumor cells (CTC) form immune-resistant multi-cell type clusters in the portal venous circulation.

Cancer Biol Ther 2018 1;19(10):887-897. Epub 2018 Aug 1.

a Departments of Translational Research (SAL, RS, AJOA, MS, EG, Y-PS); Surgical Oncology (JPA), Florida Hospital Cancer Institute , Orlando , FL , USA.

Circulating tumor cells (CTC) enter the blood from many carcinomas and represent a likely source of metastatic dissemination. In contrast to the peripheral circulation, KRAS mutation- positive CTC thrive in the portal venous blood of patients with pancreatic ductal adenocarcinoma (PDAC). To analyze the essential interactions that contribute to carcinoma CTC growth and immune resistance, portal venous blood was collected during pancreatico-duodenectomy in 41 patients with peri-ampullary pathologies (PDAC = 11; ampullary adenocarcinoma (AA) = 15; distal cholangiocarcinoma (CC) = 6; IPMN = 7; non-malignant pancreatitis = 2). Read More

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August 2018
2 Reads
3.072 Impact Factor

Investigation of HNF-1B as a diagnostic biomarker for pancreatic ductal adenocarcinoma.

Biomark Res 2018 27;6:25. Epub 2018 Jul 27.

6Department of Pathology, Massachusetts General Hospital, Boston, MA USA.

Background: Diagnosing pancreatic ductal adenocarcinoma (PDAC) in the setting of metastasis with an unknown primary remains very challenging due to the lack of specific biomarkers. HNF-1B has been characterized as an important transcription factor for pancreatic development and was reported as a biomarker for clear cell subtype of PDAC.

Methods: To investigate the diagnostic role of HNF-1B for PDAC, we used tissue microarray (TMA) and immunohistochemistry (IHC) to characterize HNF-1B expression in a large cohort of carcinomas, including 127 primary PDACs, 47 biliary adenocarcinomas, 17 metastatic PDACs, and 231 non-pancreaticobiliary carcinomas. Read More

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July 2018
11 Reads