3,497 results match your criteria Amphetamine-Related Psychiatric Disorders

Effects of resilience on impulsivity, cognition and depression during protracted withdrawal among Chinese male methamphetamine users.

BMC Psychiatry 2022 Jun 21;22(1):414. Epub 2022 Jun 21.

School of Mental Health, Wenzhou Medical University, Chashan Higher Education Park, Ouhai District, Wenzhou, 325000, China.

Background: Methamphetamine (METH) dependence is a complex and dynamic public health problem. Long-term abuse of METH can increase numerous risks of mental and physical problems. Currently, the methods to reduce METH dependence and improve the withdrawal symptoms are limited and ineffective. Read More

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Oxytocin as an adolescent treatment for methamphetamine addiction after early life stress in male and female rats.

Neuropsychopharmacology 2022 Jul 17;47(8):1561-1573. Epub 2022 May 17.

School of Psychological Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.

Early life stress (ELS) is associated with perturbed neural development and augmented vulnerability to mental health disorders, including addiction. How ELS changes the brain to increase addiction risk is poorly understood, and there are no therapies which target this ELS-induced vulnerability. ELS disrupts the oxytocin system, which can modulate addiction susceptibility, suggesting that targeting the oxytocin system may be therapeutic in this ELS-addiction comorbidity. Read More

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Selective Inhibition of PDE4B Reduces Methamphetamine Reinforcement in Two C57BL/6 Substrains.

Int J Mol Sci 2022 Apr 28;23(9). Epub 2022 Apr 28.

Department of Psychological and Brain Sciences, University of California Santa Barbara, Santa Barbara, CA 93106-9660, USA.

Methamphetamine (MA) is a highly addictive psychostimulant drug, and the number of MA-related overdose deaths has reached epidemic proportions. Repeated MA exposure induces a robust and persistent neuroinflammatory response, and the evidence supports the potential utility of targeting neuroimmune function using non-selective phosphodiesterase 4 (PDE4) inhibitors as a therapeutic strategy for attenuating addiction-related behavior. Off-target, emetic effects associated with non-selective PDE4 blockade led to the development of isozyme-selective inhibitors, of which the PDE4B-selective inhibitor A33 was demonstrated recently to reduce binge drinking in two genetically related C57BL/6 (B6) substrains (C57BL/6NJ (B6NJ) and C57BL/6J (B6J)) that differ in their innate neuroimmune response. Read More

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An adaptive design to screen, treat, and retain people with opioid use disorders who use methamphetamine in methadone clinics (STAR-OM): study protocol of a clinical trial.

Trials 2022 Apr 23;23(1):342. Epub 2022 Apr 23.

Center for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, Los Angeles, USA.

Background: Methamphetamine use could jeopardize the current efforts to address opioid use disorder and HIV infection. Evidence-based behavioral interventions (EBI) are effective in reducing methamphetamine use. However, evidence on optimal combinations of EBI is limited. Read More

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Associations between alexithymia, parental rearing styles, and frequency of drug use in male methamphetamine dependence patients.

BMC Psychiatry 2022 04 19;22(1):276. Epub 2022 Apr 19.

School of Mental Health and Psychological Sciences, Anhui Medical University, 69 Meishan Road, Hefei, 230032, Anhui Province, China.

Background: Alexithymia, which is characterized by difficulty identifying and describing feelings, is a stable personality trait and it has been associated with early life experiences. Methamphetamine dependence patients with high level of alexithymia may be particularly vulnerable to engaging in more frequent methamphetamine use. Therefore, we aimed to evaluate whether alexithymia was associated with frequency of methamphetamine use. Read More

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Impact of two different types of exercise training on AMPH addiction: Role of hippocampal neurotrophins.

Physiol Behav 2022 07 8;251:113804. Epub 2022 Apr 8.

Pós-Graduação em Bioquímica Toxicológica; Universidade Federal de Santa Maria (UFSM), RS, Brazil; Pós-Graduação em Farmacologia; UFSM, RS, Brazil.

Introduction: Amphetamine (AMPH) abuse results in neurobehavioral alterations related to the reward circuit. The hippocampus plays a role in cognition, reward, and drug addiction. There are no pharmacological approaches to prevent AMPH relapse. Read More

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The effect of adolescent social isolation on vulnerability for methamphetamine addiction behaviours in female rats.

Psychopharmacology (Berl) 2022 Apr 26;239(4):1129-1141. Epub 2022 Mar 26.

Department of Psychology, C3A, Macquarie University, North Ryde, NSW, 2109, Australia.

Rationale: Stress exposure during adolescence contributes to developing a methamphetamine (METH) use disorder. However, most of the studies investigating addiction-related behaviours include only male rodents, despite METH addiction rates being higher in females. Furthermore, animal studies investigating the effects of stress on methamphetamine addiction have used only basic self-administration models which may not be sensitive to the effects of stress. Read More

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Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice.

Biomed Pharmacother 2022 May 24;149:112837. Epub 2022 Mar 24.

NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China; Faculty of Life science and Technology, Kunming University of Science and Technology, Kunming 650500, China; School of Medicine, Yunnan University, Kunming 650091, China. Electronic address:

Background: Metformin exhibits therapeutic potential in behavioural deficits induced by methamphetamine (METH) in rats. Emerging studies suggest gut microbiota may impact psychiatric symptoms, but there is no direct evidence supporting metformin's participation in the pathophysiology of withdrawal symptoms via modulation of gut microbiota.

Methods: In order to define the functional impacts of gut microbiota and metformin to the behavioural deficits during METH withdrawal, we utilized a combination of fecal microbiota transplantation (FMT), high-throughput sequencing, and untargeted metabolomics technologies. Read More

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Evidence for gender differences in the Amphetamine/Methamphetamine ratio in the hair of subjects undergoing Fitness-to-Drive testing.

Clin Chim Acta 2022 May 9;530:87-93. Epub 2022 Mar 9.

Department of Toxicology and Forensic Toxicology, Synlab MVZ Weiden GmbH, Weiden, Germany.

Background And Aims: Retrospective analysis of hair testing data provides insights in drugs abuse patterns and improves results interpretation. Cases from subjects undergoing driving fitness assessment (2010-2020) were examined to evidence patterns in methamphetamine (MA) abuse.

Materials And Methods: All cases with positive MA (≥0. Read More

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Current Situation of Methamphetamine Abuse and Related Research Progress.

Fa Yi Xue Za Zhi 2021 Dec;37(6):763-775

School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.

Drug problem is a major social and public security problem in the world. Drug abuse poses a great threat to economic development, social stability and public health. In recent years, synthetic drugs represented by methamphetamine have surpassed traditional drugs such as morphine, heroin, ketamine and become one of the most abused drugs in the world. Read More

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December 2021

Methamphetamine-Associated Cardiomyopathy: Addressing the Clinical Challenges.

Heart Lung Circ 2022 May 10;31(5):616-622. Epub 2022 Feb 10.

School of Medicine, University of Adelaide, Adelaide, SA, Australia; Department of Cardiology, Central Adelaide Local Health Network, Adelaide, SA, Australia; Heart Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia; Centre for Heart Rhythm Disorders, University of Adelaide, Adelaide, SA, Australia. Electronic address:

The growth in methamphetamine usage worldwide continues to present increasing societal and health care challenges. With the escalation of its usage in a variety of social demographics, the entity of methamphetamine-associated cardiomyopathy (MA-CMP) has emerged. This entity is increasingly responsible for an important proportion of heart failure burden in both admissions to hospital and in those individuals requiring chronic heart failure care. Read More

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Circulating microRNA miR-137 as a stable biomarker for methamphetamine abstinence.

Psychopharmacology (Berl) 2022 Mar 9;239(3):831-840. Epub 2022 Feb 9.

Convergence Research Center for Diagnosis, Treatment and Care System of Dementia (DTC), Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

Objective: Stimulant use instigates abstinence syndrome in humans. miRNAs are a critical component for the pathophysiology of stimulant abstinence. Here we sought to identify a miRNA marker of methamphetamine abstinence in the circulating extracellular vesicles (cEVs). Read More

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Intranasal Oxytocin for Stimulant Use Disorder Among Male Veterans Enrolled in an Opioid Treatment Program: A Randomized Controlled Trial.

Front Psychiatry 2021 17;12:804997. Epub 2022 Jan 17.

Department of Psychiatry and Behavioral Sciences, San Francisco School of Medicine and San Francisco VA Health Care System, University of California, San Francisco, San Francisco, CA, United States.

The increasing prevalence of illicit stimulant use among those in opioid treatment programs poses a significant risk to public health, stimulant users have the lowest rate of retention and poorest outcomes among those in addiction treatment, and current treatment options are limited. Oxytocin administration has shown promise in reducing addiction-related behavior and enhancing salience to social cues. We conducted a randomized, double-blind, placebo-controlled clinical trial of intranasal oxytocin administered twice daily for 6 weeks to male Veterans with stimulant use disorder who were also receiving opioid agonist therapy and counseling ( = 42). Read More

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January 2022

Variables associated with methamphetamine use within the past year and sex differences among patients with methamphetamine use disorder: A cross-sectional study in Japan.

Am J Addict 2022 03 31;31(2):134-141. Epub 2022 Jan 31.

Department of Drug Dependence Research, National Center of Neurology and Psychiatry, Tokyo, Japan.

Background And Objectives: Methamphetamine use disorder is the most common reason for psychiatrist visits among illicit drug users in Japan. Although variables associated with methamphetamine use and sex differences have been reported in the United States, Australia, and Asian countries, such studies are rare in Japan. We examined methamphetamine use within the past year among patients receiving treatment by sex and proposed important treatment targets. Read More

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The effects of alcohol drinking on subsequent methamphetamine self-administration and relapse in adolescent female rats.

Behav Brain Res 2022 03 24;422:113771. Epub 2022 Jan 24.

Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

Alcohol and Methamphetamine (Meth) are widely abused drugs that are frequently co-abused, though this pattern of polysubstance abuse is rarely studied. Alcohol use during adolescence is associated with subsequent Meth dependence in humans and female adolescents may be more vulnerable than males to serial alcohol and Meth use. However, it is unknown if prior alcohol drinking impacts subsequent Meth-taking in female rats. Read More

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Differential methamphetamine-induced behavioral effects in male and female mice lacking regulator of G Protein signaling 4.

Behav Brain Res 2022 04 24;423:113770. Epub 2022 Jan 24.

Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, 525 S Main Street, Ada, OH 45810 United States

Methamphetamine-induced behavioral effects are mediated by several neurotransmitters that act via the G-protein coupled receptors (GPCRs). The functioning of GPCRs are negatively regulated by regulators of G-protein signaling (RGS) proteins. The goal of this study was to assess the role of two specific RGS proteins namely the RGS2 and the RGS4 proteins in methamphetamine-induced behaviors. Read More

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The relationship between serum brain-derived neurotrophic level and neurocognitive functions in chronic methamphetamine users.

Neurosci Lett 2022 02 24;772:136478. Epub 2022 Jan 24.

Research Center for Addiction and Risky Behaviors, Iran University of Medical Sciences, Tehran, Iran; Department of Addiction, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Methamphetamine (METH) is a highly addictive psychostimulant with serious neurotoxic effects. Given evidence indicating that brain-derived neurotrophic factor (BDNF) is associated with addictive behaviors, this study aimed to investigate the serum level of BDNF and cognitive functions in chronic METH users and healthy participants. Thirty-seven chronic METH users and 37 healthy participants were recruited in this study. Read More

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February 2022

Difference in topological organization of white matter structural connectome between methamphetamine and heroin use disorder.

Behav Brain Res 2022 03 14;422:113752. Epub 2022 Jan 14.

Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, 710038, China. Electronic address:

The psychological symptoms caused by heroin and methamphetamine are significantly different in people with substance use disorders. The topological organization of structural connections that may underlie these differences remains unknown. The study sample consisted of 23 males with methamphetamine use disorder (MAUD), 20 males with heroin use disorder (HUD), and 21 male healthy controls (HCs) who were demographically matched. Read More

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A rare case of renal infarction due to heroin and amphetamine abuse: case report.

BMC Nephrol 2022 01 12;23(1):28. Epub 2022 Jan 12.

Hematologist/Oncologist at Mercy Catholic Medical Center, Philadelphia, USA.

Background: Renal infarctions as a result of recreational drug use are rare and are commonly associated with cocaine use. Although amphetamines have a similar mechanism of action as cocaine, there are few reports linking them to ischemic events, and only one to renal infarction. Similarly, few reports link heroin use with infarcts, but never in the kidney. Read More

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January 2022

Craving among individuals with stimulant use disorder in residential social model-based treatment - Can exercise help?

Drug Alcohol Depend 2022 02 31;231:109247. Epub 2021 Dec 31.

Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Veterans Affairs Greater Los Angeles Healthcare System.

Background: In a randomized controlled 8-week trial, we examined the efficacy of aerobic and resistance exercise in reducing craving for methamphetamine (MA) among individuals with MA-use disorder during residential treatment.

Methods: Individuals with MA use disorder (138) who were newly enrolled in residential treatment volunteered for random assignment to either an 8-week exercise intervention (EX) or health education control (HE), with both conditions meeting 3 times weekly; 3 dropped out of the trial, bringing the analysis sample to 135. The majority of participants were male (80%), and 48% were Latino/Hispanic. Read More

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February 2022

Metabolomics changes after rTMS intervention reveal potential peripheral biomarkers in methamphetamine dependence.

Eur Neuropsychopharmacol 2022 03 3;56:80-88. Epub 2022 Jan 3.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China; CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Sciences, Shanghai, China. Electronic address:

Methamphetamine is one of the most commonly used drugs around the world, leading to serious public health and psychiatric problems. Due to the lackness of objective laboratory evaluation indicators, the molecular mechanisms of methamphetamine dependence still remain unclear. Previous evidence demonstrated that repetitive transcranial magnetic stimulation (rTMS) may be useful in treating drug addiction. Read More

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Vision loss and methamphetamine use.

Med J Aust 2022 Feb 30;216(2):72. Epub 2021 Dec 30.

Royal Melbourne Hospital, Melbourne, VIC.

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February 2022

Decreased peripheral mtDNA in methamphetamine use disorder.

Sci China Life Sci 2022 03 23;65(3):648-650. Epub 2021 Dec 23.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Kunming, 650204, China.

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Stimulant Drugs of Abuse and Cardiac Arrhythmias.

Circ Arrhythm Electrophysiol 2022 01 28;15(1):e010273. Epub 2021 Dec 28.

University of Iowa Carver College of Medicine, Iowa City (B.O.).

Nonmedical use of prescription and nonprescription drugs is a worldwide epidemic, rapidly growing in magnitude with deaths because of overdose and chronic use. A vast majority of these drugs are stimulants that have various effects on the cardiovascular system including the cardiac rhythm. Drugs, like cocaine and methamphetamine, have measured effects on the conduction system and through several direct and indirect pathways, utilizing multiple second messenger systems, change the structural and electrical substrate of the heart, thereby promoting cardiac dysrhythmias. Read More

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January 2022

Prior Methamphetamine Use Disorder History Does Not Impair Interoceptive Processing of Soft Touch in HIV Infection.

Viruses 2021 12 10;13(12). Epub 2021 Dec 10.

Department of Psychiatry, University of California, San Diego 9500 Gilman Drive, MC 0738 La Jolla, San Diego, CA 92093, USA.

Introduction: Interoception, defined as the sense of the internal state of one's body, helps motivate goal-directed behavior. Prior work has shown that methamphetamine (METH) use disorder is associated with altered interoception, and that this may contribute to risky behavior. As people with HIV (PWH) may also experience disrupted bodily sensations (e. Read More

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December 2021

Did the under-reporting of meth/amphetamine use increase in a general population survey in Australia as negative media coverage increased?

Addiction 2022 Jun 19;117(6):1787-1793. Epub 2022 Jan 19.

National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, Australia.

Aim: To test (1) if there was a change in self-reported lifetime prevalence of meth/amphetamine use by birth cohort and (2) if the extent of under-reporting of meth/amphetamine use was associated with the proportion of the population who nominated meth/amphetamine as a drug problem.

Design: Observational study using seven waves of repeated cross-sectional nationally representative household surveys between 2001 and 2019.

Setting: Australia. Read More

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Loneliness, Risky Beliefs and Intentions about Practicing Safer Sex among Methamphetamine Dependent Individuals.

Subst Use Misuse 2022 10;57(2):295-307. Epub 2021 Dec 10.

Department of Psychiatry, School of Medicine, University of California San Diego, San Diego, California, USA.

Background: Methamphetamine use is a known predictor of riskier sexual behaviors, which can have important public health implications (e.g., HIV-transmission risk). Read More

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Impact of adolescent methamphetamine use on social cognition: A human-mice reverse translation study.

Drug Alcohol Depend 2022 01 21;230:109183. Epub 2021 Nov 21.

Department of Psychobiology, Facultad de Psicología, Universitat de Valencia, Avda. Blasco Ibáñez, 21, 46010 Valencia, Spain.

Background: Methamphetamine dependence is associated with social cognition deficits that may underpin negative social outcomes. However, there are considerable inter-individual differences in social cognition within people with methamphetamine dependence, with age of onset of methamphetamine use being a potential contributing factor.

Materials And Methods: We conducted two sequential studies examining the link between age of onset of methamphetamine use (adolescence versus young adulthood) and performance in social cognition tests: (1) a human cross-sectional study in 95 participants with methamphetamine dependence varying in age of onset (38 with adolescent onset and 57 with adult onset) and 49 drug-naïve controls; (2) a mice study in which we tested the effects of methamphetamine exposure during adolescence versus young adulthood on social interaction and aggression, and their potential neurochemical substrates in the striatal dopaminergic system. Read More

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January 2022

A transcranial magnetic stimulation protocol for decreasing the craving of methamphetamine-dependent patients.

STAR Protoc 2021 12 10;2(4):100944. Epub 2021 Nov 10.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique. Many substance use disorders lack effective treatments, and TMS is expected to reduce cravings and risk of relapse by regulating brain function. Here, we introduce three alternative TMS settings and specific operations to interfere with methamphetamine use disorders. Read More

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December 2021

Mass spectrometry-based metabolomics in hair from current and former patients with methamphetamine use disorder.

Arch Pharm Res 2021 Oct 6;44(9-10):890-901. Epub 2021 Nov 6.

College of Pharmacy, Keimyung University, 1095 Dalgubeoldaero, Dalseo-gu, Daegu, 42601, Republic of Korea.

Drug use disorder, a chronic and relapsing mental disorder, is primarily diagnosed via self-reports of drug-seeking behavioral and psychological conditions, accompanied by psychiatric assessment. Therefore, the identification of peripheral biomarkers that reflect pathological changes caused by such disorders is essential for improving treatment monitoring. Hair possesses great potential as a metabolomic sample for monitoring chronic diseases. Read More

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October 2021