2,954 results match your criteria Amphetamine-Related Psychiatric Disorders


Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 13.

Molecular and Behavioral Neuroscience Institute.

Estradiol potentiates behavioral sensitization to cocaine as well as self-administration of cocaine and other drugs of abuse in female rodents. Furthermore, stimulated dopamine (DA) in the dorsolateral striatum (DLS) is rapidly enhanced by estradiol, and it is hypothesized that this enhanced DA release mediates the more rapid escalation of drug taking seen in females, compared with males. The mechanisms mediating the effect of estradiol to enhance stimulated DA release were investigated in this study. Read More

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http://dx.doi.org/10.1523/ENEURO.0446-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374122PMC

Methamphetamine Self-Administration Elicits Sex-Related Changes in Postsynaptic Glutamate Transmission in the Prefrontal Cortex.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Jan 28.

Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425.

Preclinical and clinical research has shown that females are more vulnerable to the rewarding effects of stimulants, and it has been proposed that estrogens may play a role in this enhanced sensitivity; however sex differences in methamphetamine (METH)-induced neuroplasticity have not been explored. To address this gap in knowledge, we recorded from the prelimbic area of the prefrontal cortex (PL-PFC) of male and female rats following long access METH self-administration (SA) and investigated the resulting long-term synaptic neuroadaptations. Males and females took similar amounts of METH during SA; however, female rats exhibit significant synaptic baseline differences when compared to males. Read More

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http://dx.doi.org/10.1523/ENEURO.0401-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348447PMC
April 2019
2 Reads

Cognitive-behavioural treatment for amphetamine-type stimulants (ATS)-use disorders.

Cochrane Database Syst Rev 2018 12 22;12:CD011315. Epub 2018 Dec 22.

Department of Psychology, Mejiro University, 4-31-1 Naka-Ochiai, Shinjuku-ku, Tokyo, Japan, 161-8539.

Background: Amphetamine-type stimulants (ATS) refer to a group of synthetic stimulants including amphetamine, methamphetamine, 3,4-methylenedioxy-methamphetamine (MDMA) and related substances. ATS are highly addictive and prolonged use may result in a series of mental and physical symptoms including anxiety, confusion, insomnia, mood disturbances, cognitive impairments, paranoia, hallucinations and delusion.Currently there is no widely accepted treatment for ATS-use disorder. Read More

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http://dx.doi.org/10.1002/14651858.CD011315.pub2DOI Listing
December 2018
2 Reads

The novel psychoactive substance 3-methylmethcathinone (3-MMC or metaphedrone): A review.

Forensic Sci Int 2019 Feb 3;295:54-63. Epub 2018 Dec 3.

UCIBIO/REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal.

3-Methylmethcathinone (3-MMC or metaphedrone) is a synthetic cathinone, recently introduced in the market of the new psychoactive substances (NPS), initially to replace mephedrone (4-methylmethcathinone or 4-MMC), and rapidly widespread among drug users. 3-Methylmethcathinone is legally controlled in many countries, but is still easily available for purchase from websites, and frequently found in recreational settings. Most toxicological data on this drug come from human case reports of intoxications. Read More

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http://dx.doi.org/10.1016/j.forsciint.2018.11.024DOI Listing
February 2019
2 Reads

Chromatographic separation of R-(-)/S-(+)-enantiomers of amphetamine and methamphetamine: differentiation between single methamphetamine consumption and co-consumption with amphetamine using enantioselective quantitative LC-MS/MS analysis.

Int J Legal Med 2019 Mar 18;133(2):467-473. Epub 2018 Dec 18.

Institute of Forensic Medicine, University of Bonn, Forensic Toxicology, Stiftsplatz 12, 53111, Bonn, Germany.

The differentiation between single methamphetamine consumption and co-consumption with amphetamine is difficult, however possible by enantioselective analysis due to different preferred synthesis pathways of both substances. We quantified (R)-(-) and (S)-(+)-enantiomers of methamphetamine and amphetamine by a fast liquid chromatographic tandem-mass spectrometric method using a Lux® 3-μm AMP 150 × 3.0 mm analytical column after simple protein precipitation with methanol. Read More

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http://dx.doi.org/10.1007/s00414-018-1979-1DOI Listing
March 2019
9 Reads

Effects of Clavulanic Acid Treatment on Reinstatement to Methamphetamine, Glial Glutamate Transporters, and mGluR 2/3 Expression in P Rats Exposed to Ethanol.

J Mol Neurosci 2019 Jan 23;67(1):1-15. Epub 2018 Nov 23.

College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, University of Toledo, Health Science Campus, 3000 Arlington Avenue, HEB 282G, Toledo, OH, 43614, USA.

Evidence demonstrated that the glutamatergic system is implicated in mediating relapse to several drugs of abuse, including methamphetamine (METH). Glutamate homeostasis is maintained by a number of glutamate transporters, such as glutamate transporter type 1 (GLT-1), cystine/glutamate transporter (xCT), and glutamate aspartate transporter (GLAST). In addition, group II metabotropic glutamate receptors (mGluR2/3) were found to be implicated in relapse-seeking behavior. Read More

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http://dx.doi.org/10.1007/s12031-018-1194-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344243PMC
January 2019
16 Reads

Psychotic Symptoms Associated With Superior Vena Cava Syndrome Following Methamphetamine Abuse.

Prim Care Companion CNS Disord 2018 Nov 1;20(6). Epub 2018 Nov 1.

Department of Psychiatry, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille 13005, Marseille, France.

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http://dx.doi.org/10.4088/PCC.17l02253DOI Listing
November 2018
4 Reads

Neuroimaging of chronic MDMA ("ecstasy") effects: A meta-analysis.

Neurosci Biobehav Rev 2019 01 12;96:10-20. Epub 2018 Nov 12.

University of Basel, Department of Psychiatry (UPK), Switzerland. Electronic address:

In this meta-analysis, we aimed to assess the evidence from neuroimaging studies for chronic alterations in the brains of MDMA users. The databases PubMed, Embase, and Web of Science were searched for studies published from inception to August 24, 2018, without any language restriction. Sixteen independent studies comprising 356 MDMA users and 311 controls were included. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2018.11.004DOI Listing
January 2019
2 Reads

Psychiatric Comorbidities among People Who Inject Drugs in Hai Phong, Vietnam: The Need for Screening and Innovative Interventions.

Biomed Res Int 2018 4;2018:8346195. Epub 2018 Oct 4.

Hai Phong University of Medicine and Pharmacy, Hai Phong, Vietnam.

The objective of this study is to describe psychiatric comorbidities, associated factors, and access to psychiatric assessment and care in a cohort of people who inject drugs (PWID) in Hai Phong, Vietnam. Mental health was assessed after 12 months' follow-up using the Mini International Neuropsychiatric Interview questionnaire (MINI 5.0. Read More

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https://www.hindawi.com/journals/bmri/2018/8346195/
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http://dx.doi.org/10.1155/2018/8346195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193349PMC
February 2019
7 Reads

Methamphetamine dependence with and without psychotic symptoms: A multi-modal brain imaging study.

Neuroimage Clin 2018 22;20:1157-1162. Epub 2018 Oct 22.

Department of Psychiatry and MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa. Electronic address:

Objective: Methamphetamine dependence can lead to psychotic symptoms which may be mediated by frontal, striatal, limbic, and thalamic regions. There are few neuroimaging data that allow comparison of individuals with methamphetamine dependence who do, and do not, have psychosis. Two complementary imaging techniques were employed to investigate neurocircuitry associated with methamphetamine dependence with and without psychotic symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183033
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http://dx.doi.org/10.1016/j.nicl.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205927PMC
February 2019
4 Reads

HIV test uptake and related factors amongst heterosexual drug users in Shandong province, China.

PLoS One 2018 18;13(10):e0204489. Epub 2018 Oct 18.

Department of STI and Leprosy Prevention and Control, Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China.

Background: In China, the mode of HIV transmission and the types and routes of drug use have changed in the past decade. HIV testing amongst drug users needs further improvement.

Methods: Interviewer-administered questionnaires were used for data collection amongst 600 heterosexual drug users from the community and a municipal detention centre, where criminal suspects are supervised. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204489PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193625PMC
March 2019
7 Reads

Twin epidemics: The surging rise of methamphetamine use in chronic opioid users.

Drug Alcohol Depend 2018 12 10;193:14-20. Epub 2018 Oct 10.

Washington University, Department of Psychiatry, Campus Box 8134, 660 S. Euclid Avenue, St. Louis, MO 63110 USA.

Background/aims: Recent supply-side efforts enacted to curb the opioid epidemic have had both positive (i.e., prescription opioid abuse is on the decline) and negative outcomes (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03768716183068
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http://dx.doi.org/10.1016/j.drugalcdep.2018.08.029DOI Listing
December 2018
6 Reads

Detection of patients with methamphetamine dependence with cue-elicited heart rate variability in a virtual social environment.

Psychiatry Res 2018 12 2;270:382-388. Epub 2018 Oct 2.

Hangzhou Seventh Science and Technology Co., Ltd, Hangzhou, Zhejiang Province, China.

In the present study, we developed a methamphetamine (METH)-related virtual social environment to elicit subjective craving and physiological reactivity. Sixty-one male patients who were abstinent from METH use and 45 age-matched healthy males (i.e. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.10.009DOI Listing
December 2018
1 Read

Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain.

Prog Neuropsychopharmacol Biol Psychiatry 2019 03 5;89:303-309. Epub 2018 Oct 5.

School of Medicine and Galway Neuroscience Centre, National University of Ireland, Galway, Ireland. Electronic address:

Methamphetamine, an amphetamine derivative, is a powerful psychomotor stimulant and commonly used drug of abuse. This study examined the effect of binge-like methamphetamine (MA) dosing (4 × 4 mg/kg, s.c. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02785846173018
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http://dx.doi.org/10.1016/j.pnpbp.2018.10.003DOI Listing
March 2019
3 Reads

Patterns and sociodemographic characteristics of substance abuse in Al Qassim, Saudi Arabia: a retrospective study at a psychiatric rehabilitation center.

Ann Saudi Med 2018 Sep-Oct;38(5):319-325

Dr. Shalam M. Hussain, Department of Pharmacology and Toxicology,, Unaizah College of Pharmacy,, Qassim University, PO Box 5516,, Unaizah, Saudi Arabia, T: +966-550-911-846, sa, ORCID: http://orcid.org/0000-0002-2398-5485.

Background: The problem of substance abuse is one of the top 20 risk factors for poor health worldwide. Though widely prevalent in the Middle East, there are few studies in Saudi Arabia.

Objective: Record the pattern of substances abuse and the sociodemographic characteristics of abusers attending the local rehabilitation center. Read More

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http://dx.doi.org/10.5144/0256-4947.2018.319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180213PMC
January 2019
4 Reads

A preliminary randomized clinical trial of naltrexone reduces striatal resting state functional connectivity in people with methamphetamine use disorder.

Drug Alcohol Depend 2018 11 21;192:186-192. Epub 2018 Sep 21.

Section of Addiction Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.

Objective: Naltrexone has been shown to attenuate craving and the subjective effects of methamphetamine. Although naltrexone has modulatory effects on neural activity at dopaminergic synapses, the effect on striatal connectivity is unclear. As methamphetamine use is associated with greater resting-state functional connectivity (RSFC) in the dopaminergic system, we examined whether extended-release naltrexone (XR-NTX) can normalize striatal connectivity and whether changes in RSFC are associated with changes in craving and methamphetamine use. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.07.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200637PMC
November 2018
10 Reads

Intersecting burdens: Homophobic victimization, unstable housing, and methamphetamine use in a cohort of men of color who have sex with men.

Drug Alcohol Depend 2018 11 13;192:179-185. Epub 2018 Sep 13.

Center for Behavioral and Addiction Medicine, Department of Family Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States.

Background: Men who have sex with men with histories of homophobic victimization bear heightened risk of unstable housing and methamphetamine use. However, it is unclear whether unstable housing explains the link between homophobic victimization and methamphetamine use in this group. The present study aims to test associations between homophobic victimization, unstable housing, and recent methamphetamine use across 24 months in a cohort of men of color who have sex with men (MoCSM). Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.07.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200602PMC
November 2018
17 Reads

Differentially classified methamphetamine-using men who have sex with men: A latent class analysis.

Drug Alcohol Depend 2018 11 15;192:129-136. Epub 2018 Aug 15.

University of Minnesota School of Public Health, 420 Delaware St. SE, Minneapolis, MN 55455, USA.

Context: Substance use interventions for methamphetamine-using men who have sex with men (MSM) are limited by the assumption that they are a uniform group. We hypothesized that an LCA would identify distinct patterns of substance use and demographic and psychosocial variables associated with different substance-using groups would aid in understanding distinctions. Using cross-sectional data from 343 methamphetamine-using MSM, we conducted an LCA to model the patterns of polysubstance use then examined how the classes varied on psychosocial variables defined by the Information-Motivation-Behavioral Skills (IMB) model. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.07.003DOI Listing
November 2018
4 Reads

Over the influence: The HIV care continuum among methamphetamine-using men who have sex with men.

Drug Alcohol Depend 2018 11 13;192:125-128. Epub 2018 Sep 13.

School of Medicine, University of California - San Francisco, 1600 Divisadero St., San Francisco, CA 94115 USA; Department of Public Health Sciences, University of Miami, 1120 NW 14th St., Office 1005, Miami, FL 33136 USA. Electronic address:

Background: HIV-positive persons who use stimulants such as methamphetamine experience greater difficulties in navigating the HIV care continuum. In the era of HIV treatment as prevention (TasP), little is known about the prevalence and correlates of success along the HIV care continuum among people who use stimulants.

Setting: San Francisco, California USA METHODS: Cross-sectional study that enrolled 129 HIV-positive men who have sex with men (MSM) from 2013 through 2017 who had biologically confirmed, recent methamphetamine use. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.07.038DOI Listing
November 2018
5 Reads
3.423 Impact Factor

Polydrug use among heroin users in Cleveland, OH.

Drug Alcohol Depend 2018 11 22;192:80-87. Epub 2018 Aug 22.

Department of Anthropology, Case Western Reserve University, 11220 Bellflower Rd., Cleveland, OH 44106, USA. Electronic address:

Background: Since 2000, heroin use patterns have shifted within the United States. How this change may relate to polydrug use among local heroin users is unknown. Although polydrug use has been studied, user perceptions of drug use in terms of health risks, arrest risk, availability, cost, liking, and dependence have not been considered. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.06.039DOI Listing
November 2018
2 Reads

Association between serum malondialdehyde levels and depression during early methamphetamine withdrawal.

Neurosci Lett 2018 11 13;687:22-25. Epub 2018 Sep 13.

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China. Electronic address:

Some evidence suggested that malondialdehyde (MDA) as a marker of oxidative stress played an important part in modulating the activities of depression. Methamphetamine (METH) dependence often lead to depression that may associate with MDA. In this study, our purpose was to explore the association between serum MDA levels and depression during METH withdrawal. Read More

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http://dx.doi.org/10.1016/j.neulet.2018.09.021DOI Listing
November 2018
2 Reads

Randomized controlled trial of a positive affect intervention for methamphetamine users.

Drug Alcohol Depend 2018 11 5;192:8-15. Epub 2018 Sep 5.

Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, 633 N. Saint Clair St., 19th Floor, Chicago, IL 60611 USA.

Background: Contingency management (CM) is an evidence-based intervention providing rewards in exchange for biomarkers that confirm abstinence from stimulants such as methamphetamine. We tested the efficacy of a positive affect intervention designed to boost the effectiveness of CM with HIV-positive, methamphetamine-using sexual minority men.

Methods: This attention-matched, randomized controlled trial of a positive affect intervention delivered during CM was registered on www. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200638PMC
November 2018
2 Reads

Pharmacotherapy for amphetamine dependence: A systematic review.

Drug Alcohol Depend 2018 10 22;191:309-337. Epub 2018 Aug 22.

360Edge Consulting, P.O. Box 359, Elwood, 3184, Victoria, Australia; Department of General Practice, University of Melbourne, 200 Berkeley Street, Carlton, Victoria, 3053, Australia.

Background: Demand for treatment for amphetamine use is increasing internationally. Establishing effective pharmacotherapy provides broader treatment options for people who are dependent on amphetamine and may encourage engagement in evidence-based behavioral treatment. This study aimed to identify medicines that have potential in improving treatment outcomes for people who are dependent on amphetamines. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.06.038DOI Listing
October 2018
4 Reads

Amphetamine Self-Administration and Its Extinction Alter the 5-HT Receptor Protein Levels in Designated Structures of the Rat Brain.

Neurotox Res 2019 Jan 30;35(1):217-229. Epub 2018 Aug 30.

Department of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland.

Manipulation of the serotonin (5-HT) receptors can modify the behavioral effects of amphetamine including its reinforcing properties. Focus of this study was to examine changes in 5-HT receptor protein expression in several brain structures linked to substance drug disorder in different stages of amphetamine addiction-single session of amphetamine self-administration, 20 consecutive days of amphetamine self-administration, and 3 and 14 days of extinction from chronic drug intake. "Yoked" procedure was employed to set apart pharmacological and motivational effects of amphetamine intoxication. Read More

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http://dx.doi.org/10.1007/s12640-018-9950-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313351PMC
January 2019
4 Reads

[Change of brain structure imaging of long-term withdrawal of methamphetamine-dependent patients].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jan;43(1):41-48

Department of Biomedical Engineering and Radiology,School of Medicine, Wayne State University, Detroit MI 48201, USA.

Objective: To explore the characteristics of brain structure in patients with long-term withdrawal of methamphetamine-dependence.
 Methods: A total of 44 patients with withdrawal of methamphetamine-dependent for more than 14 months were recruited, who met the diagnostic criteria for substance dependence in the fifth edition of the American Mental Disorders Diagnostic and Statistical Manual (DSM-V), and 40 healthy subjects were used as the control. In addition to the general scale of drug-relevant survey, the subjects received the 3. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.01.007DOI Listing
January 2018
18 Reads

Cue reactivity and opioid blockade in amphetamine dependence: A randomized, controlled fMRI study.

Drug Alcohol Depend 2018 10 26;191:91-97. Epub 2018 Jul 26.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Stockholm County Council, Norra Stationsgatan 69, SE-113 64, Stockholm, Sweden.

Background: The opioid antagonist, naltrexone, has been shown to reduce the risk of relapse in amphetamine dependence, but the mechanisms behind this effect are not well understood. We aimed to investigate if naltrexone attenuates cue reactivity and craving in amphetamine dependence.

Methods: Forty men with severe, intravenous amphetamine dependence were randomized to one dose of naltrexone (50 mg) or placebo. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.06.023DOI Listing
October 2018
1 Read

Prenatal ethanol exposure increases risk of psychostimulant addiction.

Behav Brain Res 2019 01 1;356:51-61. Epub 2018 Aug 1.

Research Institute on Addictions and Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1021 Main Street, Buffalo, NY, 14203, USA. Electronic address:

Prenatal ethanol exposure (PE) causes many cognitive and behavioral deficits including increased drug addiction risk, demonstrated by enhanced ethanol intake and behavioral phenotypes associated with addiction risk. Additionally, preclinical studies show that PE persistently changes the function of dopaminergic neurons in the ventral tegmental area, a major neural substrate for addiction, and alters these neurons' responses to psychostimulants. Accordingly, PE could also lead to increased risk of addiction to drugs of abuse, other than ethanol. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.07.030DOI Listing
January 2019
6 Reads

The prevalence of substance-induced psychotic disorder in methamphetamine misusers: A meta-analysis.

Psychiatry Res 2018 10 17;268:189-192. Epub 2018 May 17.

Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, Faculty of Medicine, University of Montreal, Montreal, Canada. Electronic address:

There is little consensus regarding the prevalence of methamphetamine-induced psychotic disorder (MIPD). A search of the literature was performed, effect size estimates were calculated with event rates and were aggregated with a random-effects model. Seventeen studies were included in the meta-analysis, resulting in a composite event rate of 36. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.05.033DOI Listing
October 2018
15 Reads

Coronary sinus flow is reduced in methamphetamine abusers: a transthoracic echocardiographic study.

Int J Cardiovasc Imaging 2018 Dec 21;34(12):1889-1894. Epub 2018 Jul 21.

Department of Ultrasound, Jiangsu Province Tumor Hospital, 42 Baiziting Road, Nanjing, 210009, Jiangsu, People's Republic of China.

To compare the coronary sinus flow among healthy participants, methamphetamine abusers without chest pain and those with chest pain. One hundred and eight methamphetamine abusers: 53 ones without chest pain, 55 ones with chest pain, free of ascertained coronary artery disease, were enrolled in this study. A control group of 50 age-matched male healthy participants was studied for comparison. Read More

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http://dx.doi.org/10.1007/s10554-018-1417-yDOI Listing
December 2018
13 Reads

Low-frequency repetitive transcranial magnetic stimulation inhibits the development of methamphetamine-induced conditioned place preference.

Behav Brain Res 2018 11 9;353:129-136. Epub 2018 Jul 9.

Collaborative Innovation Center for Brain Science, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. Electronic address:

The abuse of amphetamine-type stimulants (ATS) has become a global public health issue in recent years, these new-type drugs can cause addiction and serious cognitive impairment. However, there are no effective methods for the prevention and treatment of ATS addiction at present. Repetitive transcranial magnetic stimulation (rTMS) is a painless and non-invasive new therapeutic approach that has been used for the treatment of depression and other neuropsychiatric disorders, but whether it can be used to treat drug addiction is unclear. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.07.004DOI Listing
November 2018
28 Reads

Amphetamine use in the fourth decade of life: Social profiles from a population-based Australian cohort.

Drug Alcohol Rev 2018 09 11;37(6):743-751. Epub 2018 Jul 11.

Centre for Adolescent Health, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.

Introduction And Aims: To estimate the prevalence and frequency of amphetamine use in a cohort of Australians aged in their mid-30s.

Design And Methods: Cross-sectional analysis of wave 10 data collected in 2014 from the Victorian Adolescent Health Cohort Study: a sample of 1435 persons originally selected in a stratified, random community survey of secondary school students from the state of Victoria that commenced in 1992. Weighted multinomial regression models were used to evaluate the social, health and other substance-use correlates of lifetime and current (12-month) amphetamine use and current frequency of use. Read More

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http://doi.wiley.com/10.1111/dar.12840
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http://dx.doi.org/10.1111/dar.12840DOI Listing
September 2018
16 Reads

Simultaneous Determination of Amphetamine-Related New Psychoactive Substances in Urine by Gas Chromatography-Mass Spectrometry.

J Anal Toxicol 2018 Nov;42(9):605-616

Forensic Genetics & Chemistry Division, Supreme Prosecutors' Office, Seoul, Republic of Korea.

Despite the efforts to prevent the spread of new psychoactive substances (NPS) such as synthetic amphetamine derivatives, it is apparent that newer types of NPS are still emerging on the market in recent years. Due to high potential for their abuse, reliable analytical methods are required to determine these substances in biological samples. The objective of this study was to develop and validate the gas chromatography-mass spectrometric (GC-MS) method for the simultaneous determination of 13 amphetamine-related NPS (amphetamine; AP, 4-fluoroamphetamine; 4FA, methamphamine; MA, 4-fluoromethamphetamine; 4FMA, 4-chloroamphetamine; 4CA, para-methoxyamphetamine; PMA, 4-chloromethamphetamine; 4CMA, 6-(2-aminopropyl)benzofuran; 6APB, 4-methylenedioxyamphetamine; MDA, para-methoxymethamphetamine; PMMA, 6-(2-methylaminopropyl)benzofuran; 6MAPB, 3,4-methylenedioxymethamphetamine; MDMA, 5,6-methylenedioxy-2-aminoindane; MDAI) in urine. Read More

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http://dx.doi.org/10.1093/jat/bky037DOI Listing
November 2018
12 Reads

Thioredoxin-1 downregulation in the nucleus accumbens promotes methamphetamine-primed reinstatement in mice.

Neuropharmacology 2018 09 4;139:117-123. Epub 2018 Jul 4.

Medical Faculty, Kunming University of Science and Technology, Kunming, 650500, China. Electronic address:

Relapse of drug abuse after abstinence is a major challenge to the treatment of addicts. Thioredoxin-1 (Trx-1) is an important regulator of neuroprotection, and inhibits morphine-induced hyperlocomotion, reward and withdrawal signs, as well as blocks methamphetamine (METH)-induced conditioned place preference (CPP). The nucleus accumbens (NAc) is essential for relapse like behavior in reinstatement animal models. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283908183035
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http://dx.doi.org/10.1016/j.neuropharm.2018.07.003DOI Listing
September 2018
17 Reads

Maximal strength training improves musculoskeletal health in amphetamine users in clinical treatment.

Osteoporos Int 2018 Oct 5;29(10):2289-2298. Epub 2018 Jul 5.

Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Amphetamine use leads to impaired skeletal health and elevated risk of osteoporosis. In the current study, we document that maximal strength training (MST), as a part of clinical treatment, works as a countermeasure, improving muscle force generating capacity, body composition, and skeletal health at sites particularly prone to osteoporotic fractures.

Introduction: Amphetamine users have attenuated musculoskeletal health. Read More

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http://link.springer.com/10.1007/s00198-018-4623-5
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http://dx.doi.org/10.1007/s00198-018-4623-5DOI Listing
October 2018
10 Reads

Limited modulation of the abuse-related behavioral effects of d-methamphetamine by disulfiram.

Exp Clin Psychopharmacol 2018 Oct 2;26(5):497-502. Epub 2018 Jul 2.

Preclinical Pharmacology Laboratory, McLean Hospital.

Disulfiram (Antabuse), an acetaldehyde dehydrogenase and dopamine-beta hydroxylase inhibitor, has shown promise in preclinical and clinical studies as a pharmacotherapy for cocaine addiction. However, the extent to which disulfiram may alter the abuse-related behavioral effects of related psychostimulants, such as methamphetamine, is unknown. Here, the therapeutic potential of disulfiram was evaluated by examining its impact on the reinforcing and discriminative stimulus effects of d-methamphetamine in adult rhesus monkeys (N = 4 per group). Read More

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http://dx.doi.org/10.1037/pha0000222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162099PMC
October 2018
25 Reads

Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse.

PLoS One 2018 29;13(6):e0200060. Epub 2018 Jun 29.

Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.

Methamphetamine (METH) substance abuse disorders have major impact on society, yet no medications have proven successful at preventing METH relapse or cravings. Anti-METH monoclonal antibodies can reduce METH brain concentrations; however, this therapy has limitations, including the need for repeated dosing throughout the course of addiction recovery. An adeno-associated viral (AAV)-delivered DNA sequence for a single-chain variable fragment could offer long-term, continuous expression of anti-METH antibody fragments. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200060PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025879PMC
December 2018
3 Reads

Individualized texting for adherence building (iTAB) for methamphetamine users living with HIV: A pilot randomized clinical trial.

Drug Alcohol Depend 2018 08 21;189:154-160. Epub 2018 Jun 21.

Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.

Background: Methamphetamine (METH) use poses a barrier to antiretroviral therapy (ART) adherence. We evaluated the efficacy of the individualized texting for adherence building (iTAB) intervention among persons living with HIV (PLWH) who meet criteria for METH use disorder. We examined daily associations between ART adherence and text-reported METH use and depressed mood. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324532PMC
August 2018
5 Reads

Methamphetamine-associated difficulties in cognitive control allocation may normalize after prolonged abstinence.

Prog Neuropsychopharmacol Biol Psychiatry 2019 01 25;88:41-52. Epub 2018 Jun 25.

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Germany.

Chronic heavy methamphetamine use likely causes dopaminergic neurotoxicity, which is commonly thought to result in cognitive control deficits. Both of these alterations may persist even after the use is discontinued, but tend to (partly) improve with increasing duration of abstinence. While several studies have demonstrated that the reinstatement of comparatively normal dopaminergic signaling may take months, if not years, the amelioration of cognitive deficits has predominantly been investigated in much shorter intervals of several weeks to less than half a year. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2018.06.015DOI Listing
January 2019
3 Reads

Office-Based Addiction Treatment in Primary Care: Approaches That Work.

Med Clin North Am 2018 Jul;102(4):635-652

Department of Internal Medicine, Yale University School of Medicine, 367 Cedar Street, Suite 305, New Haven, CT 06510, USA.

Primary care is an important setting for delivering evidence-based treatment to address substance use disorders. To date, effective approaches to treat, care largely incorporate pharmacotherapy with counseling-based interventions and rely on multidisciplinary teams. There is strong support for primary care-based approaches to address alcohol and opioid use disorder with growing data focused on people living with human immunodeficiency virus and those experiencing incarceration. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.02.007DOI Listing
July 2018
5 Reads

Postoperative catecholamine resistance following fetal methamphetamine exposure.

Asian Cardiovasc Thorac Ann 2019 Jan 22;27(1):30-32. Epub 2018 Jun 22.

1 Queensland Paediatric Cardiac Services, Lady Cilento Children's Hospital, Brisbane, Australia.

Methamphetamine and its related compounds are among the most widely abused recreational drugs worldwide. While a myriad of clinical complications of methamphetamine use have been described, there is a paucity of literature regarding the effects of maternal abuse during pregnancy on neonatal hearts. In this report, we describe a neonate who underwent Norwood-type palliation and subsequently developed catecholamine-resistant cardiogenic shock, likely related to methamphetamine exposure, which recovered after a period of venoarterial extracorporeal membrane oxygenation support. Read More

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http://dx.doi.org/10.1177/0218492318784740DOI Listing
January 2019
12 Reads

Relationship between function of hypothalamic-pituitary-adrenal axis and executive functions in chronic methamphetamine users: A cross-sectional study.

Asian J Psychiatr 2018 Jun 4;35:113-114. Epub 2018 Jun 4.

Department of Psychiatry, Behavior Research Centre of Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1016/j.ajp.2018.05.001DOI Listing
June 2018
1 Read

Gaps in the ice: Methamphetamine in Australia; its history, treatment, and ramifications for users and their families.

Int J Ment Health Nurs 2018 Dec 5;27(6):1861-1868. Epub 2018 Jun 5.

School of Nursing and Midwifery, Edith Cowan University, Perth, Western Australia, Australia.

It is now well-established that Australia has a significant issue with methamphetamine. Recent dramatic changes in manufacturing have led to significant shifts in both the patterns of use and the relative purity of this illicit drug, with the crystalline form of methamphetamine commonly referred to as 'ice'. Excessive use not only impacts on those taking the drug, but also takes a heavy toll on their families. Read More

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http://dx.doi.org/10.1111/inm.12480DOI Listing
December 2018
1 Read

Varenicline treatment for methamphetamine dependence: A randomized, double-blind phase II clinical trial.

Drug Alcohol Depend 2018 Aug 25;189:30-36. Epub 2018 May 25.

Department of Family Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Background: Previous studies have suggested that varenicline, an α4β2 nicotinic receptor partial agonist, and α7 nicotinic receptor full agonist, may be effective for the treatment of methamphetamine (MA) dependence due to dopaminergic effects, relief of glutamatergic and cognitive dysfunction, and activation of nicotinic cholinergic systems. This study aimed to determine if varenicline (1 mg BID) resulted in reduced methamphetamine use compared to placebo among treatment-seeking MA-dependent volunteers.

Methods: Treatment-seeking MA-dependent volunteers were randomized to varenicline 1 mg twice daily (n = 27) or placebo (n = 25) and cognitive behavioral therapy for 9 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03768716183028
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http://dx.doi.org/10.1016/j.drugalcdep.2018.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391991PMC
August 2018
20 Reads

Association between cytochrome P450 2D6 polymorphisms and body fluid methamphetamine concentrations in Japanese forensic autopsy cases.

Forensic Sci Int 2018 Aug 18;289:33-39. Epub 2018 May 18.

Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan.

Methamphetamine (MA) is an illicit stimulant that affects the central nervous system. Cytochrome P450 2D6 (CYP2D6) plays an important role in MA metabolism. Numerous allelic variants confer substantial variation in CYP2D6 activity among individuals. Read More

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http://dx.doi.org/10.1016/j.forsciint.2018.05.018DOI Listing
August 2018
11 Reads

False-positive amphetamine results on several drug screening platforms due to mexiletine.

Clin Biochem 2018 Aug 23;58:125-127. Epub 2018 May 23.

Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, United States.

Objective: False-positive urine drug of abuse screening (UDS) results can have serious implications in clinical practice, particularly when confirmation assay results are not immediately available to providers making medical decisions. Often it is not possible to identify the specific medication or other interfering compound that is responsible for the false-positive UDS result. Even when a potential interference is reported in the literature or package insert for one assay, the applicability to other UDS platforms/assays is often unknown. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2018.05.013DOI Listing
August 2018
10 Reads

Comparative hazards of acute myocardial infarction among hospitalized patients with methamphetamine- or cocaine-use disorders: A retrospective cohort study.

Drug Alcohol Depend 2018 07 26;188:259-265. Epub 2018 Apr 26.

Human Brain Laboratory, Centre for Addiction and Mental Health (CAMH), 33 Russell St., Toronto, ON M5S 2S1, Canada.

Background: It is assumed that recreational use of methamphetamine can trigger acute myocardial infarction (AMI) events, but estimates of longitudinal hazards of AMI among methamphetamine users are lacking.

Methods: Retrospective cohort study: Competing-risks analysis was used to estimate time-to-AMI patterns in methamphetamine versus matched appendicitis (population-proxy) and matched cocaine (drug-control) groups. Cohorts were propensity-score-matched using demographic and clinical variables. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.03.030DOI Listing
July 2018
7 Reads

Methamphetamine consumption and life-threatening abdominal complications: A case report.

Medicine (Baltimore) 2018 May;97(18):e0647

Department of Critical Care Medicine.

Rationale: Methamphetamine (METH) abuse is increasing rapidly all over the world and becoming a significant public health concern in China. However, abdominal complications secondary to METH abuse are usually overlooked. We describe an unusual case of gangrenous cholecystitis and small intestinal ischemia due to METH abuse. Read More

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http://dx.doi.org/10.1097/MD.0000000000010647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392995PMC
May 2018
8 Reads

Relationship between the duration of methamphetamine use and psychotic symptoms: A two-year prospective cohort study.

Drug Alcohol Depend 2018 06 22;187:363-369. Epub 2018 Apr 22.

National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China; Institute of Mental Health, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health and Peking University Sixth Hospital, Peking University, Beijing, 100191, China; Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100191, China. Electronic address:

Background: Psychosis is a key harm associated with methamphetamine (MA) use. This study examined the relationship between the duration of MA use and risk of psychotic symptoms.

Methods: A cohort of 528 individuals with chronic MA use was followed for two years after leaving treatment center in Guangdong, China. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.03.023DOI Listing
June 2018
9 Reads

Age- and sex-dependent effects of methamphetamine on cognitive flexibility and 5-HT receptor localization in the orbitofrontal cortex of Sprague-Dawley rats.

Behav Brain Res 2018 09 30;349:16-24. Epub 2018 Apr 30.

Department of Psychology, University of Illinois, Urbana-Champaign, 603 E. Daniel St., Champaign, IL, 61820, USA; Neuroscience Program, University of Illinois, Urbana-Champaign, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA. Electronic address:

Adolescents and females experience worse outcomes of drug use compared to adults and males. This could result from age- and sex-specific consequences of drug exposure on brain function and cognitive behavior. In the current study, we examined whether a history of intravenous methamphetamine (METH) self-administration impacted cognitive flexibility and 5-HTR localization in the orbitofrontal cortex (OFC) in an age- and sex-dependent manner. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.04.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993617PMC
September 2018
7 Reads