3,332 results match your criteria Amphetamine-Related Psychiatric Disorders


Amphetamine use and psychiatric admissions: a 10-year perspective.

Australas Psychiatry 2021 May 19:10398562211014227. Epub 2021 May 19.

Sydney Medical School, Northern Clinical School, University of Sydney, North Ryde, NSW, Australia.

Objective: We aimed to (i) describe the 10-year trend in admissions associated with amphetamine use, (ii) describe the distinguishing characteristics of people with an amphetamine-related diagnosis (ARD) and (iii) examine predictors of repeated admissions among people with an ARD.

Method: We conducted a retrospective cohort study. We (i) counted the number of admissions with an ARD and evaluated any trends, and using univariate and multivariate tests, (ii) compared those who had an ARD with those who did not and (iii) compared those with an ARD who had one, two to four, and five or more admissions. Read More

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Safety and tolerability of oral lisdexamfetamine in adults with methamphetamine dependence: a phase-2 dose-escalation study.

BMJ Open 2021 05 18;11(5):e044696. Epub 2021 May 18.

Drug and Alcohol Clinical Research and Improvement Network, C/O South East Sydney Local Health District, Sydney, New South Wales, Australia.

Objectives: To examine the safety of an agonist-type treatment, lisdexamfetamine (LDX), at 250 mg/day among adults with methamphetamine (MA) dependence.

Design: A dose-escalating, phase-2, open-label, single-group study of oral LDX at two Australian drug treatment services.

Setting: The study was conducted at two Australian stimulant use disorder treatment clinics. Read More

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Methamphetamine use and technology-mediated psychosocial interventions: A mini-review.

Addict Behav 2021 Oct 23;121:106881. Epub 2021 Feb 23.

Turning Point, Eastern Health, 110 Church St., Richmond, VIC 3121, Australia; Monash Alfred Psychiatry Research Centre, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC 3004, Australia. Electronic address:

Engagement with face-to-face psychosocial interventions is often compromised in people using methamphetamine (MA), in the context of high rates of polysubstance use, mental health disorders, cognitive impairment and geographic isolation. Technology-mediated interventions offer flexible ways of engaging with treatment and are readily accessible. This mini-review evaluates evidence from eight studies for the effectiveness of telephone, mHealth (text-messaging and apps) and computer-based interventions for MA use. Read More

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October 2021

Cue Exposure Triggers Inhibitory Deficits in Individuals With Methamphetamine Use Disorder.

J Stud Alcohol Drugs 2021 03;82(2):197-203

Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian 116029, China.

Objective: Inhibitory deficits contribute to impulsive drug-seeking behavior in individuals with methamphetamine use disorder (MUD). Whether abstinent individuals with MUD exhibit greater cognitive disinhibition when the suppressed response is associated with drug-related images is not fully known. This study evaluated the potency of drug-associated cue exposure in this process. Read More

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Urinary retention concomitant with methamphetamine use: a case report.

J Med Case Rep 2021 Apr 2;15(1):183. Epub 2021 Apr 2.

Clinical III, Faculty of Clinical Sciences, LAUTECH, Ogbomoso, Nigeria.

Background: Urinary retention is a condition in which impaired emptying of the bladder results in postvoid residual urine. It can be acute or chronic urinary retention. There have been only scattered case studies that have described urinary retention resulting from methamphetamine use. Read More

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Sex-dependent right ventricular hypertrophic gene changes after methamphetamine treatment in mice.

Eur J Pharmacol 2021 Jun 28;900:174066. Epub 2021 Mar 28.

Institute of Cardiovascular & Medical Sciences and College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

Methamphetamine (MA) abuse is associated with the development of pulmonary arterial hypertension (PAH) and subsequent right ventricular failure. A recent clinical study demonstrated that female sex is a major risk factor for MA-induced PAH. The mechanisms associated with increased prevalence and severity of MA-induced PAH in females are still unclear. Read More

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919 syrup inhibits ROS-mediated leptin-induced anorexia by activating PPARγ and improves gut flora abnormalities.

Biomed Pharmacother 2021 Jun 10;138:111455. Epub 2021 Mar 10.

Department of Traditional Chinese Medicine, Jinshan Hospital of Fudan University, Shanghai, China. Electronic address:

Background: Women with postpartum psychiatric disorders are prone to severe anorexia. Clinical studies have revealed the efficacy of 919 syrup, a traditional Chinese medicine mixture against postpartum illnesses, such as in regulating maternal mood and improving postpartum anorexia.

Aim: This study investigated the mechanisms through which 919 syrup improved anorexia induced by postpartum stress, focussing on the combined peroxisome proliferator-activated receptor gamma (PPARγ) and leptin signalling pathway, and its effects on the structure of the gut flora. Read More

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Methamphetamine-related postmortem cases in Jeddah, Saudi Arabia.

Forensic Sci Int 2021 Apr 26;321:110746. Epub 2021 Feb 26.

King Abdul-Aziz Hospital, Laboratory Department, Jeddah, Saudi Arabia. Electronic address:

A more than 500% increase in the number of deaths involving methamphetamine occurred between 2016 and 2018 in Jeddah, Saudi Arabia. As such, this report employed a validated liquid chromatography tandem mass spectrometry method to quantify methamphetamine and its metabolites in bodily fluids from 47 postmortem cases in which methamphetamine was involved. The mean age of the deceased was 33 years old (median: 30, range: 16-63), and 94% were male. Read More

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A COVID-19 pregnant patient with thrombotic thrombocytopenic purpura: a case report.

J Med Case Rep 2021 Mar 1;15(1):104. Epub 2021 Mar 1.

Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Pregnancy seems to increase the risk of thrombotic thrombocytopenic purpura (TTP) relapses and make the TTP more severe in any of the pregnancy trimesters, or even during the postpartum period.

Case Presentation: This study highlights details of treating a COVID-19 pregnant patient who survived. This 21-year addicted White woman was admitted at her 29th week and delivered a stillbirth. Read More

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Alpha-pyrrolidinopentiophenone and mephedrone self-administration produce differential neurochemical changes following short- or long-access conditions in rats.

Eur J Pharmacol 2021 Apr 10;897:173935. Epub 2021 Feb 10.

Center for Drug Discovery, RTI International, 3040 Cornwallis Rd, Research Triangle Park, NC, 27709, USA.

Stimulant-induced neurochemical changes may occur at different times for different brain regions or neurotransmitter systems. This study sought to examine the behavioral and neurochemical effects of extended access to α-pyrrolidinopentiophenone (α-PVP) and 4-methylmethcathinone (4MMC). Male and female Sprague-Dawley rats were trained to self-administer α-PVP (0. Read More

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Bupropion and Naltrexone in Methamphetamine Use Disorder.

N Engl J Med 2021 01;384(2):140-153

From the Peter O'Donnell Jr. Brain Institute at the University of Texas Southwestern Medical Center (M.H.T.) and the University of Texas Southwestern Medical Center (R.W., A.C., T.C., M.K., K.S.-W., S.W.), Dallas, the University of Texas Health Science Center at Houston, Houston (J.S.), and Texas Tech University, Permian Basin, Odessa (A.J.R.); the University of California, Los Angeles, Los Angeles (W.L., S. Shoptaw); the Emmes Company, Rockville (G.S., A.W.), and the National Institute on Drug Abuse Center for the Clinical Trials Network (U.E.G., S. Sparenborg [retired]), Rockville - both in Maryland; the San Francisco Department of Public Health and the University of California, San Francisco, San Francisco (P.C.); CODA, Portland, OR (K.W.); Hennepin Healthcare, University of Minnesota, Minneapolis (G.B.); Medical University of South Carolina, Charleston (S.C.S.); Duke-National University of Singapore, Singapore (A.J.R.); Duke Medical School, Durham, NC (A.J.R.); and Columbia University, New York (E.V.N.).

Background: The use of naltrexone plus bupropion to treat methamphetamine use disorder has not been well studied.

Methods: We conducted this multisite, double-blind, two-stage, placebo-controlled trial with the use of a sequential parallel comparison design to evaluate the efficacy and safety of extended-release injectable naltrexone (380 mg every 3 weeks) plus oral extended-release bupropion (450 mg per day) in adults with moderate or severe methamphetamine use disorder. In the first stage of the trial, participants were randomly assigned in a 0. Read More

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January 2021

Adding extended-release methylphenidate to psychological intervention for treatment of methamphetamine dependence: A double-blind randomized controlled trial.

Med J Islam Repub Iran 2020 14;34:137. Epub 2020 Oct 14.

Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran.

Iran has been faced with an emerging epidemic of methamphetamine (MA) use during recent years. No effective pharmacotherapy has been identified for MA treatment; and psychological interventions are the only available effective treatment. The aim of this study is to investigate the efficacy and safety of extended-release methylphenidate (ER-MTP) for the treatment of methamphetamine dependence. Read More

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October 2020

Hyperthermia associated with methamphetamine and cocaine use.

Am J Emerg Med 2021 04 5;42:20-22. Epub 2021 Jan 5.

Department of Emergency Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH, United States of America.

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Methamphetamine seeking after prolonged abstinence is associated with activated projections from anterior intralaminar nucleus of thalamus to dorsolateral striatum in female rats.

Pharmacol Biochem Behav 2021 01 11;200:173087. Epub 2020 Dec 11.

Department of Psychology, University of Maryland College Park, College Park, MD 20742, United States of America. Electronic address:

Methamphetamine (Meth) seeking progressively increases after cessation from drug self-administration (incubation of Meth craving). We have previously shown that both dorsomedial and dorsolateral striatum (DMS and DLS) play critical roles in this incubation in male rats. Moreover, our recent anatomical tracing study examined afferent projections into DMS and demonstrated a novel role of projections from anterior intralaminar nucleus of thalamus (AIT) to DMS in incubation of Meth craving in male rats. Read More

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January 2021

Invasive pneumococcal disease confirmed in five different sites including Austrian syndrome in a male patient with methamphetamine abuse.

BMJ Case Rep 2020 Dec 10;13(12). Epub 2020 Dec 10.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.

A 60-year-old man with no significant medical history was found unresponsive by his neighbour; he had neck stiffness on physical examination in the emergency department. He later developed acute hypoxic respiratory failure requiring endotracheal intubation. He is a binge drinker on weekends, and methamphetamine was detected in his urine. Read More

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December 2020

Vaccine development against methamphetamine drug addiction.

Expert Rev Vaccines 2020 12 10;19(12):1105-1114. Epub 2020 Dec 10.

Institute for Health and Sport, Victoria University , Melbourne, VIC, Australia.

Introduction: There are currently no effective treatments for Methamphetamine (METH) addiction and psychotherapy remains the sole treatment option. The development of immunopharmacotherapies for the treatment of drug addiction, overdose, and relapse management appears to be promising alternative and a significant body of information has been generated using various vaccine development strategies. Herein, we present an update on the developments toward anti-METH vaccines and their study outcomes in preclinical and clinical studies. Read More

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December 2020

Transcriptional Profiling of Whisker Follicles and of the Striatum in Methamphetamine Self-Administered Rats.

Int J Mol Sci 2020 Nov 23;21(22). Epub 2020 Nov 23.

College of Pharmacy, Keimyung University, Daegu 42601, Korea.

Methamphetamine (MA) use disorder is a chronic neuropsychiatric disease characterized by recurrent binge episodes, intervals of abstinence, and relapses to MA use. Therefore, identification of the key genes and pathways involved is important for improving the diagnosis and treatment of this disorder. In this study, high-throughput RNA sequencing was performed to find the key genes and examine the comparability of gene expression between whisker follicles and the striatum of rats following MA self-administration. Read More

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November 2020

A qualitative exploration of the factors associated with initiation to methamphetamine use in Iran.

BMC Public Health 2020 Nov 23;20(1):1773. Epub 2020 Nov 23.

Health Education and Promotion, Environmental Health Research Center, Faculty of Health, Golestan University of Medical Sciences, Late Falsefi University Complex, KM 5of Gorgan-Sari Road, Golestan, Iran.

Background: Crystal (methamphetamine) is a strong stimulant of addictive substances that affects the central nervous system. The consumption of this substance is increasing among teenagers and adult young people in the country. In this matter, one of the practical and important ways to its control is to identify the factors leading to its first use. Read More

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November 2020

Methamphetamine pre-exposure induces steeper escalation of methamphetamine self-administration with consequent alterations in hippocampal glutamate AMPA receptor mRNAs.

Eur J Pharmacol 2020 Dec 18;889:173732. Epub 2020 Nov 18.

Molecular Neuropsychiatry Research Branch, DHHS/NIH/NIDA Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD, 21224, USA. Electronic address:

Methamphetamine use disorder (MUD) is often modeled using rodent self-administration (SA) experiments. Noncontingent injections of a drug given to rodents before self-administration training can increase drug SA. In the present study, we injected methamphetamine before putting rats through methamphetamine SA to investigate SA escalation. Read More

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December 2020

Service Involvement Across Multiple Sectors Among People Who Use Opioids, Methamphetamine, or Both, United States-2015-2018.

Med Care 2021 03;59(3):238-244

Hennepin Healthcare Research Institute, Minneapolis, MN.

Background: The fourth wave of the opioid crisis is characterized by increased use and co-use of methamphetamine. How opioid and methamphetamine co-use is associated with health care use, housing instability, social service use, and criminal justice involvement has not been studied and could inform future interventions and partnerships.

Objectives: To estimate service involvement across sectors among people who reported past year opioid and methamphetamine co-use, methamphetamine use, opioid use, or neither opioid nor methamphetamine use. Read More

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Falling methamphetamine-related presentations to a clinical toxicology unit during the COVID-19 pandemic.

Emerg Med Australas 2021 02 6;33(1):179-180. Epub 2020 Nov 6.

Clinical Toxicology Unit, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

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February 2021

Australian news media reporting of methamphetamine: an analysis of print media 2014-2016.

Aust N Z J Public Health 2020 Dec 26;44(6):468-475. Epub 2020 Oct 26.

School of Public Health and Community Medicine, UNSW Sydney, New South Wales.

Objectives: To examine the representation and framing in Australian print media of methamphetamine and methamphetamine users from 2014 to 2016 when media attention was heightened around the National Ice Taskforce, including the implications of the coverage and framing in limiting public health responses to the problem.

Methods: A quantitative media content analysis examined media portrayals of methamphetamine, including crystalline methamphetamine (also referred to by other names including 'crystal' or 'ice'), in 1,364 Australian print media articles published 2014-2016.

Results: The largest number of articles about methamphetamine were published in 2015 with a higher proportion of these articles framed as a crisis than in other years. Read More

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December 2020

Measurement invariance and psychometric properties of Perceived Stigma toward People who use Substances (PSPS) among three types of substance use disorders: Heroin, amphetamine, and alcohol.

Drug Alcohol Depend 2020 11 28;216:108319. Epub 2020 Sep 28.

Departments of Psychiatry and Neuroscience and the Child Study Center, School of Medicine, Yale University, New Haven, CT, USA; Connecticut Council on Problem Gambling, Wethersfield, CT, USA; Connecticut Mental Health Center, New Haven, CT, USA.

Background: The 8-item self-report Perceived Stigma toward Substance Users Scale (PSAS) is a commonly used instrument to assess stigma for people with substance use disorders. This study aimed to develop and validate the Taiwan version of the PSAS entitled Perceived Stigma toward People who use Substances - Taiwan version (PSPS-TV) among individuals with substance use disorders.

Methods: Patients with substance use disorders (N = 300; mean age = 45. Read More

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November 2020

Amphetamine dependence in Australia.

Lancet 2020 10;396(10256):957

Clinical and Health Sciences, Health and Biomedical Innovation, University of South Australia, Adelaide, SA 5000, Australia.

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October 2020

Contingency management for the treatment of methamphetamine use disorder: A systematic review.

Drug Alcohol Depend 2020 11 21;216:108307. Epub 2020 Sep 21.

Western Michigan University, United States. Electronic address:

Methamphetamine use continues to be an important public health problem. Contingency management is among the most effective interventions for reducing methamphetamine use. It has been more than ten years since the last systematic review of contingency management for methamphetamine use disorder. Read More

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November 2020

Prevalence of obesity among U.S. population with substance dependence.

Drug Alcohol Depend 2020 12 15;217:108293. Epub 2020 Sep 15.

The Emmes Company, LLC, Rockville, MD 20850, USA. Electronic address:

Aim: To investigate associations between substance dependence and obesity.

Methods: Obesity (body mass index ≥ 30 kg/m) status and the status of dependence on heroin, stimulant, marijuana, nicotine and alcohol (past-month status for nicotine and past-year status for all others) were identified from the U.S. Read More

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December 2020

The contribution of methamphetamine use to crime: Evidence from Australian longitudinal data.

Drug Alcohol Depend 2020 11 30;216:108262. Epub 2020 Aug 30.

National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.

Background: To quantify the extent to which methamphetamine use is associated with increases in crime net of any premorbid risk of criminality among people who use the drug.

Methods: Four one-month data panels from 469 participants dependent on methamphetamine were drawn from the MATES cohort (N = 501). Odds ratios for within-person effects were extracted from a random intercept logistic regression model for crime during periods of methamphetamine use compared to no use. Read More

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November 2020

Substance use disorders and chronic itch.

J Am Acad Dermatol 2021 Jan 3;84(1):148-155. Epub 2020 Sep 3.

Dr Phillip Frost Department of Dermatology and Miami Itch Center, University of Miami, Miami, Florida. Electronic address:

Chronic pruritus is one dermatologic manifestation of an underlying substance use disorder. Recent literature has uncovered similarities between the general neurologic mechanisms of addiction and chronic itch, largely involving activation of the dopaminergic reward circuits within the brain and imbalances between mu and kappa opioid receptor activation. It is likely that the use of specific drugs, like central nervous system stimulants and opioids, results in further activation and imbalances within these pathways, perpetuating both addiction and pruritus simultaneously. Read More

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January 2021

Sustained attention and vigilance deficits associated with HIV and a history of methamphetamine dependence.

Drug Alcohol Depend 2020 10 22;215:108245. Epub 2020 Aug 22.

Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, United States; VA Center of Excellence for Stress and Mental Health, Veterans Administration San Diego HealthCare System, 3350 La Jolla Village Drive, San Diego, CA, 92161, United States.

Background: Human immunodeficiency virus (HIV)-associated neurocognitive disorders persist in the era of antiretroviral therapy. One factor that is elevated among persons with HIV (PWH) and independently associated with neurocognitive impairment is methamphetamine dependence (METH). Such dependence may further increase cognitive impairment among PWH, by delaying HIV diagnosis (and thus, antiretroviral therapy initiation), which has been posited to account for persistent cognitive impairment among PWH, despite subsequent treatment-related viral load suppression (VLS; <50 copies of the virus per milliliter in plasma or cerebrospinal fluid). Read More

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October 2020

AMPed-up adolescents: The role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development.

Pharmacol Biochem Behav 2020 11 20;198:173016. Epub 2020 Aug 20.

Department of Psychology, University of Illinois at Urbana-Champaign, USA; Neuroscience Program, University of Illinois at Urbana-Champaign, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, USA. Electronic address:

Adolescent use of amphetamine and its closely related, methylated version methamphetamine, is alarmingly high in those who use drugs for nonmedical purposes. This raises serious concerns about the potential for this drug use to have a long-lasting, detrimental impact on the normal development of the brain and behavior that is ongoing during adolescence. In this review, we explore recent findings from both human and laboratory animal studies that investigate the consequences of amphetamine and methamphetamine exposure during this stage of life. Read More

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November 2020