3,099 results match your criteria Amphetamine-Related Psychiatric Disorders


Molecular Docking Studies of Methamphetamine and Amphetamine-Related Derivatives as an Inhibitor against dopamine Receptor.

Curr Comput Aided Drug Des 2018 Dec 4. Epub 2018 Dec 4.

Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud. Iran.

Background: The catecholamines such as dopamine, norepinephrine, and epinephrine are neurotransmitters that regulate different physiological functions of the central nervous system. Some evidence suggest that the degeneration of dopamine neurons in the substantia nigra contributes in Parkinson's disease (PD), which is a neurodegenerative disorder and it is responsible for the major symptoms of PD. It is suggested that replenishment of striatal dopamine through the oral administration of the dopamine precursor, levodopa, can compensate the lack of endogenously produced dopamine. Read More

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December 2018
3 Reads

Amphetamine- and Opioid-Affected Births: Incidence, Outcomes, and Costs, United States, 2004-2015.

Am J Public Health 2018 Nov 29:e1-e7. Epub 2018 Nov 29.

Lindsay K. Admon and Vanessa K. Dalton are with the Department of Obstetrics and Gynecology at the University of Michigan, Ann Arbor. L. K. Admon was also with the US Department of Veterans Affairs, Ann Arbor, at the time this work was completed. Caroline R. Richardson is with the Department of Family Medicine at the University of Michigan. Katy B. Kozhimannil is with the Division of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis. Gavin Bart is with the Division of Addiction Medicine, Department of Medicine at Hennepin Healthcare, Minneapolis. Tyler N. A. Winkelman is in the Division of General Internal Medicine and the Hennepin Healthcare Research Institute, Hennepin Healthcare.

Objectives: To estimate trends in incidence, outcomes, and costs among hospital deliveries related to amphetamines and opioids.

Methods: We analyzed 2004-to-2015 data from the National Inpatient Sample, a nationally representative sample of hospital discharges in the United States compiled by the Healthcare Cost and Utilization Project, by using a repeated cross-sectional design. We estimated the incidence of hospital deliveries related to maternal amphetamine or opioid use with weighted logistic regression. Read More

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November 2018

Which individual, social and environmental influences shape key phases in the amphetamine type stimulant use trajectory? A systematic narrative review and thematic synthesis of the qualitative literature.

Addiction 2018 Sep 3. Epub 2018 Sep 3.

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Background And Aims: There is limited evidence on what shapes amphetamine-type stimulant (ATS) use trajectories. This systematic narrative review and qualitative synthesis aimed to identify individual, social and environmental influences shaping key phases in the ATS use trajectory: initiation, continuation, increase/relapse and decrease/abstinence.

Methods: MEDLINE, PsycINFO, EMBASE, and PROQUEST (social science premium collection) were searched from 2000 to 2018. Read More

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September 2018
2 Reads

[Change of brain structure imaging of long-term withdrawal of methamphetamine-dependent patients].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jan;43(1):41-48

Department of Biomedical Engineering and Radiology,School of Medicine, Wayne State University, Detroit MI 48201, USA.

Objective: To explore the characteristics of brain structure in patients with long-term withdrawal of methamphetamine-dependence.
 Methods: A total of 44 patients with withdrawal of methamphetamine-dependent for more than 14 months were recruited, who met the diagnostic criteria for substance dependence in the fifth edition of the American Mental Disorders Diagnostic and Statistical Manual (DSM-V), and 40 healthy subjects were used as the control. In addition to the general scale of drug-relevant survey, the subjects received the 3. Read More

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January 2018
6 Reads

Low-frequency repetitive transcranial magnetic stimulation inhibits the development of methamphetamine-induced conditioned place preference.

Behav Brain Res 2018 11 9;353:129-136. Epub 2018 Jul 9.

Collaborative Innovation Center for Brain Science, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. Electronic address:

The abuse of amphetamine-type stimulants (ATS) has become a global public health issue in recent years, these new-type drugs can cause addiction and serious cognitive impairment. However, there are no effective methods for the prevention and treatment of ATS addiction at present. Repetitive transcranial magnetic stimulation (rTMS) is a painless and non-invasive new therapeutic approach that has been used for the treatment of depression and other neuropsychiatric disorders, but whether it can be used to treat drug addiction is unclear. Read More

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November 2018
18 Reads

Simultaneous Determination of Amphetamine-Related New Psychoactive Substances in Urine by Gas Chromatography-Mass Spectrometry.

J Anal Toxicol 2018 Nov;42(9):605-616

Forensic Genetics & Chemistry Division, Supreme Prosecutors' Office, Seoul, Republic of Korea.

Despite the efforts to prevent the spread of new psychoactive substances (NPS) such as synthetic amphetamine derivatives, it is apparent that newer types of NPS are still emerging on the market in recent years. Due to high potential for their abuse, reliable analytical methods are required to determine these substances in biological samples. The objective of this study was to develop and validate the gas chromatography-mass spectrometric (GC-MS) method for the simultaneous determination of 13 amphetamine-related NPS (amphetamine; AP, 4-fluoroamphetamine; 4FA, methamphamine; MA, 4-fluoromethamphetamine; 4FMA, 4-chloroamphetamine; 4CA, para-methoxyamphetamine; PMA, 4-chloromethamphetamine; 4CMA, 6-(2-aminopropyl)benzofuran; 6APB, 4-methylenedioxyamphetamine; MDA, para-methoxymethamphetamine; PMMA, 6-(2-methylaminopropyl)benzofuran; 6MAPB, 3,4-methylenedioxymethamphetamine; MDMA, 5,6-methylenedioxy-2-aminoindane; MDAI) in urine. Read More

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November 2018
6 Reads

How uncertainty sensitizes dopamine neurons and invigorates amphetamine-related behaviors.

Neuropsychopharmacology 2018 Jun 29. Epub 2018 Jun 29.

Department of Biopsychology, University of Bochum, Bochum, Germany.

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Individualized texting for adherence building (iTAB) for methamphetamine users living with HIV: A pilot randomized clinical trial.

Drug Alcohol Depend 2018 08 21;189:154-160. Epub 2018 Jun 21.

Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.

Background: Methamphetamine (METH) use poses a barrier to antiretroviral therapy (ART) adherence. We evaluated the efficacy of the individualized texting for adherence building (iTAB) intervention among persons living with HIV (PLWH) who meet criteria for METH use disorder. We examined daily associations between ART adherence and text-reported METH use and depressed mood. Read More

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August 2018
1 Read

Office-Based Addiction Treatment in Primary Care: Approaches That Work.

Med Clin North Am 2018 Jul;102(4):635-652

Department of Internal Medicine, Yale University School of Medicine, 367 Cedar Street, Suite 305, New Haven, CT 06510, USA.

Primary care is an important setting for delivering evidence-based treatment to address substance use disorders. To date, effective approaches to treat, care largely incorporate pharmacotherapy with counseling-based interventions and rely on multidisciplinary teams. There is strong support for primary care-based approaches to address alcohol and opioid use disorder with growing data focused on people living with human immunodeficiency virus and those experiencing incarceration. Read More

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July 2018
4 Reads

Varenicline treatment for methamphetamine dependence: A randomized, double-blind phase II clinical trial.

Drug Alcohol Depend 2018 08 25;189:30-36. Epub 2018 May 25.

Department of Family Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Background: Previous studies have suggested that varenicline, an α4β2 nicotinic receptor partial agonist, and α7 nicotinic receptor full agonist, may be effective for the treatment of methamphetamine (MA) dependence due to dopaminergic effects, relief of glutamatergic and cognitive dysfunction, and activation of nicotinic cholinergic systems. This study aimed to determine if varenicline (1 mg BID) resulted in reduced methamphetamine use compared to placebo among treatment-seeking MA-dependent volunteers.

Methods: Treatment-seeking MA-dependent volunteers were randomized to varenicline 1 mg twice daily (n = 27) or placebo (n = 25) and cognitive behavioral therapy for 9 weeks. Read More

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August 2018
14 Reads

Association between cytochrome P450 2D6 polymorphisms and body fluid methamphetamine concentrations in Japanese forensic autopsy cases.

Forensic Sci Int 2018 Aug 18;289:33-39. Epub 2018 May 18.

Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan.

Methamphetamine (MA) is an illicit stimulant that affects the central nervous system. Cytochrome P450 2D6 (CYP2D6) plays an important role in MA metabolism. Numerous allelic variants confer substantial variation in CYP2D6 activity among individuals. Read More

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August 2018
7 Reads

False-positive amphetamine results on several drug screening platforms due to mexiletine.

Clin Biochem 2018 Aug 23;58:125-127. Epub 2018 May 23.

Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, United States.

Objective: False-positive urine drug of abuse screening (UDS) results can have serious implications in clinical practice, particularly when confirmation assay results are not immediately available to providers making medical decisions. Often it is not possible to identify the specific medication or other interfering compound that is responsible for the false-positive UDS result. Even when a potential interference is reported in the literature or package insert for one assay, the applicability to other UDS platforms/assays is often unknown. Read More

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August 2018
7 Reads

Comparative hazards of acute myocardial infarction among hospitalized patients with methamphetamine- or cocaine-use disorders: A retrospective cohort study.

Drug Alcohol Depend 2018 07 26;188:259-265. Epub 2018 Apr 26.

Human Brain Laboratory, Centre for Addiction and Mental Health (CAMH), 33 Russell St., Toronto, ON M5S 2S1, Canada.

Background: It is assumed that recreational use of methamphetamine can trigger acute myocardial infarction (AMI) events, but estimates of longitudinal hazards of AMI among methamphetamine users are lacking.

Methods: Retrospective cohort study: Competing-risks analysis was used to estimate time-to-AMI patterns in methamphetamine versus matched appendicitis (population-proxy) and matched cocaine (drug-control) groups. Cohorts were propensity-score-matched using demographic and clinical variables. Read More

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July 2018
2 Reads

Methamphetamine consumption and life-threatening abdominal complications: A case report.

Medicine (Baltimore) 2018 May;97(18):e0647

Department of Critical Care Medicine.

Rationale: Methamphetamine (METH) abuse is increasing rapidly all over the world and becoming a significant public health concern in China. However, abdominal complications secondary to METH abuse are usually overlooked. We describe an unusual case of gangrenous cholecystitis and small intestinal ischemia due to METH abuse. Read More

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May 2018
5 Reads

Relationship between the duration of methamphetamine use and psychotic symptoms: A two-year prospective cohort study.

Drug Alcohol Depend 2018 06 22;187:363-369. Epub 2018 Apr 22.

National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China; Institute of Mental Health, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health and Peking University Sixth Hospital, Peking University, Beijing, 100191, China; Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100191, China. Electronic address:

Background: Psychosis is a key harm associated with methamphetamine (MA) use. This study examined the relationship between the duration of MA use and risk of psychotic symptoms.

Methods: A cohort of 528 individuals with chronic MA use was followed for two years after leaving treatment center in Guangdong, China. Read More

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June 2018
4 Reads

Age- and sex-dependent effects of methamphetamine on cognitive flexibility and 5-HT receptor localization in the orbitofrontal cortex of Sprague-Dawley rats.

Behav Brain Res 2018 09 30;349:16-24. Epub 2018 Apr 30.

Department of Psychology, University of Illinois, Urbana-Champaign, 603 E. Daniel St., Champaign, IL, 61820, USA; Neuroscience Program, University of Illinois, Urbana-Champaign, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA. Electronic address:

Adolescents and females experience worse outcomes of drug use compared to adults and males. This could result from age- and sex-specific consequences of drug exposure on brain function and cognitive behavior. In the current study, we examined whether a history of intravenous methamphetamine (METH) self-administration impacted cognitive flexibility and 5-HTR localization in the orbitofrontal cortex (OFC) in an age- and sex-dependent manner. Read More

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September 2018
2 Reads

Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice.

Behav Brain Res 2018 09 27;349:73-79. Epub 2018 Apr 27.

Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA.

Mild neurocognitive impairments are common in people with human immunodeficiency virus (HIV) infection. HIV-encoded proteins, such as trans-activator of transcription (TAT), contribute to neuropathology and cognitive function in medicated subjects. The combination of TAT and comorbid methamphetamine use may further impair neurocognitive function in HIV-positive individuals by affecting dopaminergic systems in the brain. Read More

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September 2018
2 Reads

First psychotic episode risk markers for primary psychosis amongst people who use methamphetamine.

Schizophr Res 2018 Sep 18;199:456-457. Epub 2018 Apr 18.

School of Applied Psychology, Griffith University, Brisbane, Queensland, Australia.

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September 2018

Rocuronium for control of muscle spasms in a tetanus patient with chronic methamphetamine use disorder.

BMJ Case Rep 2018 Apr 10;2018. Epub 2018 Apr 10.

Department of Neurosciences, University of the Philippines-Philippine General Hospital, Manila, Philippines.

This is a case of a 31-year-old Filipino man with chronic methamphetamine use disorder who developed tetanus from a necrotic skin graft over his left calcaneus, which was fractured after a motor vehicular accident. During the course of his illness, the patient's muscle spasms were unusually refractory to benzodiazepine, which is the first-line drug used in the management of muscle spasms. The muscle spasms were successfully controlled on the seventh day of illness with rocuronium at a dose of 10 μg/kg/min and midazolam at 0. Read More

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April 2018
10 Reads

Repeated Administration of 3,4-Methylenedioxymethamphetamine (MDMA) Elevates the Levels of Neuronal Nitric Oxide Synthase in the Nigrostriatal System: Possible Relevance to Neurotoxicity.

Neurotox Res 2018 Nov 9;34(4):763-768. Epub 2018 Apr 9.

Department of Biomedical Sciences, Section of Neuropsychopharmacology, University of Cagliari, Building A, Monserrato University Campus, SP 8, Km 0.700, 09042, Monserrato, Italy.

Previous studies have consistently demonstrated that the amphetamine-related drug 3,4-methylenedioxymethamphetamine (MDMA) induces dopaminergic damage in the mouse brain, and that this effect is most marked in the nigrostriatal system. Moreover, it has been suggested that the overproduction of nitric oxide (NO) may participate in the dopaminergic damage induced by MDMA. To further elucidate this issue, we evaluated the levels of the enzyme nitric oxide synthase (nNOS), which catalyzes the production of NO, in mice treated with regimens of MDMA that induce progressive and persistent neurotoxicity in the dopaminergic nigrostriatal system. Read More

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November 2018
1 Read

The relationship between impulsivity and methamphetamine use severity in a community sample.

Drug Alcohol Depend 2018 06 27;187:1-7. Epub 2018 Mar 27.

Department of Psychology, University of California, Los Angeles, United States. Electronic address:

Background: Abuse of psychostimulants, including methamphetamine (MA), has been linked to heightened impulsivity. While previous research has demonstrated differences in impulsivity between MA users and non-substance users, less is known about variability in impulsivity within MA users and whether the severity of MA use related problems predicts impulsivity within individuals who regularly use MA. This study aims to elucidate the relationship between impulsivity and MA use severity. Read More

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June 2018
3 Reads

Atomoxetine for amphetamine-type stimulant dependence during buprenorphine treatment: A randomized controlled trial.

Drug Alcohol Depend 2018 05 10;186:130-137. Epub 2018 Mar 10.

Centre for Drug Research, Universiti Sains Malaysia, 11800, Penang, Malaysia.

Background: Amphetamine type stimulants (ATS) use is highly prevalent and frequently co-occurs with opioid dependence in Malaysia and Asian countries. No medications have established efficacy for treating ATS use disorder. This study evaluated the safety, tolerability, and potential efficacy of atomoxetine for treating ATS use disorder. Read More

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May 2018
5 Reads
3.420 Impact Factor

A commentary on the effects of methamphetamine and the status of methamphetamine abuse among youths in South Korea, Japan, and China.

Forensic Sci Int 2018 May 26;286:81-85. Epub 2018 Feb 26.

College of Pharmacy, Duksung Women's University, Seoul, South Korea. Electronic address:

Methamphetamine (MA) abuse continues in East Asia and shows an increasing trend among youths in South Korea, Japan, and China. Although the negative effects of MA abuse on youth are considered as significant problems, few studies have been conducted on the topic in these countries. This paper focuses on the effects of MA on the human body and current MA abuse among youths in South Korea, Japan, and China. Read More

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May 2018
4 Reads

Increasing amphetamine use and forensic involvement among clients of three residential Indigenous alcohol and other drug services in Victoria, Australia.

Drug Alcohol Rev 2018 Jul 21;37(5):671-675. Epub 2018 Mar 21.

Department of Allied and Community Health, La Trobe University, Melbourne, Australia.

Introduction And Aims: Indigenous people seeking residential alcohol and other drug (AOD) rehabilitation in Victoria are most frequently referred to the Ngwala Willumbong Co-operative (Ngwala). This study aimed to describe socio-demographic changes in clients of Ngwala's residential rehabilitation services between 2015 and 2016.

Design And Methods: Self-assessment surveys completed upon screening for rehabilitation between May 2015 and November 2016 (n = 117) were analysed for socio-demographic data, AOD use and mental health status. Read More

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July 2018
1 Read

Amphetamine availability predicts amphetamine-related mental health admissions: A time series analysis.

Aust N Z J Psychiatry 2018 Nov 19;52(11):1050-1056. Epub 2018 Mar 19.

5 National Drug & Alcohol Research Centre, University of NSW Sydney, Sydney, NSW, Australia.

Objective:: Amphetamine use and availability have increased in Australia and there are concerns that this has led to more frequent hospital admissions with amphetamine-related psychosis. This study examines whether amphetamine-related admissions to mental health units are more common at times of greater amphetamine availability.

Methods:: We conducted an ecological study using aggregate crime and health service data for NSW, Australia, from January 2000 to March 2015. Read More

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November 2018
4 Reads

Role of AMPA glutamate receptors in the conditioned rewarding effects of MDMA in mice.

Behav Brain Res 2018 07 8;347:57-60. Epub 2018 Mar 8.

Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universidad de Valencia, Spain. Electronic address:

Currently, there is not an effective treatment for 3,4-methylenedioxymethamphetamine (MDMA) dependence but pharmacotherapies targeting glutamate neurotransmission are a promising strategy. Previously, we showed that blockade of glutamate NMDA and AMPA receptors impairs the conditioned rewarding effects of MDMA and cocaine, respectively. In this study we evaluated the role of AMPA receptors in the rewarding effects of MDMA in mice using the conditioned place preference (CPP) paradigm. Read More

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July 2018
1 Read

Opioids and methamphetamine: a tale of two crises.

Authors:
The Lancet

Lancet 2018 02;391(10122):713

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February 2018
1 Read

Cross-sectional cause of death comparisons for stimulant and opioid mortality in San Francisco, 2005-2015.

Drug Alcohol Depend 2018 04 21;185:305-312. Epub 2018 Feb 21.

San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 500, San Francisco, CA, United States; Department of Medicine, Division of HIV, Infectious Disease and Global Health, University of California, San Francisco, CA, United States.

Background: Opioids and stimulants (e.g., cocaine or methamphetamine/amphetamine [MAMP]) are major contributors to acute substance toxicity deaths. Read More

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April 2018
8 Reads

Crystal methamphetamine use and its correlates in women engaged in sex work in a developing country setting.

Drug Alcohol Depend 2018 04 14;185:260-265. Epub 2018 Feb 14.

HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran; Department of Epidemiology and Biostatistics and Institute for Global Health Sciences, University of California San Francisco, 550 16th St., San Francisco, CA, USA. Electronic address:

Background: Worldwide, crystal methamphetamine (CM) use and associated high-risk sexual behaviors are a concern, but they are less studied among female sex workers (FSW) in developing countries. This study aimed to characterize the prevalence and individual, interpersonal, and structural correlates of self-reported past-month CM use among FSW in Iran.

Methods: FSW aged ≥ 18 years who reported penetrative sex with more than one client in the last year were recruited (analytic sample: 1295). Read More

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April 2018
2 Reads

The impact of acute and short-term methamphetamine abstinence on brain metabolites: A proton magnetic resonance spectroscopy chemical shift imaging study.

Drug Alcohol Depend 2018 04 22;185:226-237. Epub 2018 Feb 22.

Department of Psychiatry and Mental Health, Groote Schuur Hospital, University of Cape Town, Anzio Rd., Observatory, 7925 Cape Town, South Africa; Neuroscience Institute, University of Cape Town, South Africa.

Background: Abuse of methamphetamine (MA) is a global health concern. Previous H-MRS studies have found that, with methamphetamine abstinence (MAA), there are changes in n-acetyl-aspartate (NAA/Cr), myo-inositol (mI/Cr), choline (Cho/Cr and Cho/NAA), and glutamate with glutamine (Glx) metabolites. Limited studies have investigated the effect of acute MAA, and acute-to-short-term MAA on brain metabolites. Read More

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April 2018
1 Read
3.420 Impact Factor

Olanzapine and haloperidol for the treatment of acute symptoms of mental disorders induced by amphetamine-type stimulants: A randomized controlled trial.

Medicine (Baltimore) 2018 Feb;97(8):e9786

Department of Substance Abuse, Shandong Mental Health Center, Jinan, China.

Background: This study aimed to compare olanzapine and haloperidol efficacies in the treatment of acute psychiatric symptoms due to amphetamine-type stimulants (ATSs).

Methods: The Zelen II design method was used; 124 patients with acute mental disorders due to amphetamine were randomly divided into olanzapine group (n = 63) and haloperidol group (n = 61). Then, a 4-week open-label medical therapy was performed. Read More

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February 2018
7 Reads

[Identification of Methamphetamine Abuse and Selegiline Use: Chiral Analysis of Methamphetamine and Amphetamine in Urine].

Fa Yi Xue Za Zhi 2017 Dec 25;33(6):599-603. Epub 2017 Dec 25.

Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.

Objectives: To study the content variation of selegiline and its metabolites in urine, and based on actual cases, to explore the feasibility for the identification of methamphetamine abuse and selegiline use by chiral analysis.

Methods: The urine samples were tested by chiral separation and LC-MS/MS method using CHIROBIOTIC™ V2 chiral liquid chromatography column. The chiral analysis of methamphetamine and amphetamine were performed on the urine samples from volunteers of selegiline use and drug addicts whom suspected taking selegiline. Read More

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December 2017
3 Reads

HIV treatment optimism and crystal methamphetamine use and initiation among HIV-negative men who have sex with men in Vancouver, Canada: A longitudinal analysis.

Drug Alcohol Depend 2018 04 8;185:67-74. Epub 2018 Feb 8.

British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada; Department of Medicine, University of British Columbia, Vancouver, Canada.

Background: Treatment as Prevention (TasP) leading to increased HIV treatment optimism among men who have sex with men (MSM) has been previously associated with behavioural risk compensation, though not yet via crystal methamphetamine (CM) use. Among HIV-negative MSM in a TasP environment, this study aimed to investigate the prevalence of recent CM use over time, examine the association between HIV treatment optimism and CM use and initiation, and identify correlates of recent CM use and predictors of CM initiation.

Methods: Using data from a prospective behavioural cohort study of sexually active MSM in the Vancouver area, we used multi-level generalized mixed effect models to evaluate temporal trends in CM use, univariable and multivariable logistic regression to identify covariates of recent CM use, and univariable and multivariable survival analysis to identify predictors of CM initiation. Read More

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April 2018
2 Reads

Glucosensing capacity of rainbow trout telencephalon.

J Neuroendocrinol 2018 Mar;30(3):e12583

Laboratorio de Fisioloxía Animal, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía and Centro de Investigación Mariña, Universidade de Vigo, Vigo, Spain.

To assess the hypothesis of glucosensing systems present in fish telencephalon, we first demonstrated in rainbow trout, by in situ hybridisation, the presence of glucokinase (GK). Then, we assessed the response of glucosensing markers in rainbow trout telencephalon 6 hours after i.c. Read More

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March 2018
1 Read

The role of venues in structuring HIV, sexually transmitted infections, and risk networks among men who have sex with men.

BMC Public Health 2018 02 7;18(1):225. Epub 2018 Feb 7.

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Background: Venues form part of the sampling frame for time-location sampling, an approach often used for HIV surveillance. While sampling location is often regarded as a nuisance factor, venues may play a central role in structuring risk networks. We investigated individual reports of risk behaviors and infections among men who have sex with men (MSM) attending different venues to examine structuring of HIV risk behaviors. Read More

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February 2018
1 Read

Methamphetamine dependence in methadone treatment services in Iran: the first literature review of a new health concern.

Asian J Psychiatr 2018 Jan 6;31:49-55. Epub 2018 Jan 6.

Program of International Research and Training, National Drug and Alcohol Research Centre, School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia.

Background: Methamphetamine dependence is a serious health problem among Iranian methadone patients.

Aim: The current study is the first research that reviewed the prevalence of methamphetamine dependence and the associated harms among Iranian methadone patients. The other aims were to review the history of receiving methamphetamine treatment among methadone patients and the evaluated psychosocial treatments for methamphetamine dependence and/or associated harms. Read More

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January 2018
5 Reads

Disappearance of R/S-methamphetamine and R/S-amphetamine from human scalp hair after discontinuation of methamphetamine abuse.

Forensic Sci Int 2018 Mar 31;284:153-160. Epub 2018 Jan 31.

Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Guangfu Xi Road 1347, Shanghai 200063, China. Electronic address:

Methamphetamine (MA) and amphetamine (AM) are widely abused drugs. These compounds contain a chiral center, and their enantiomers exhibit different pharmacologic, pharmacokinetic, and metabolic properties due to differences in binding affinities to their receptor sites. Until now, there was a lack of information on the decline in the concentration of drugs in hair after abstinence. Read More

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March 2018
5 Reads

Chronic amphetamine treatment affects collicular-dependent behaviour.

Behav Brain Res 2018 05 3;343:1-7. Epub 2018 Feb 3.

School of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK7 6AA, UK; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK. Electronic address:

Distractibility can be defined as an attention deficit where orientation toward irrelevant targets cannot be inhibited. There is now mounting evidence that the superior colliculus is a key neural correlate of distractibility, with increased collicular-activity resulting in heightened distractibility. Heightened distractibility is reduced by amphetamine, which acutely suppresses collicular responsiveness. Read More

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May 2018
2 Reads

Parallel Effects of Methamphetamine on Anxiety and CCL3 in Humans and a Genetic Mouse Model of High Methamphetamine Intake.

Neuropsychobiology 2017 18;75(4):169-177. Epub 2018 Jan 18.

Research and Development Service, VA Portland Health Care System, Portland, Oregon, USA.

Background: Methamphetamine (MA) abuse causes immune dysfunction and neuropsychiatric impairment. The mechanisms underlying these deficits remain unidentified.

Methods: The effects of MA on anxiety-like behavior and immune function were investigated in mice selectively bred to voluntarily consume high amounts of MA [i. Read More

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September 2018
3 Reads

Gender-specific differences in high-risk sexual behaviors among methamphetamine users in Myanmar-China border city, Muse, Myanmar: who is at risk?

BMC Public Health 2018 02 1;18(1):209. Epub 2018 Feb 1.

Department of Community and Global Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Methamphetamine (MA) use is a significant public health concern due to its negative effects on health. However, to date, no epidemiological research has examined high-risk sexual behaviors (inconsistent condom use, having multiple sexual partners and having a history of sexually transmitted infections) among MA users. This topic is particularly important in Myanmar, which is recognized as one of the key MA production countries in the Southeast Asia region. Read More

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February 2018
4 Reads

Reduction in endogenous cardiac steroids protects the brain from oxidative stress in a mouse model of mania induced by amphetamine.

Brain Res Bull 2018 03 31;137:356-362. Epub 2018 Jan 31.

Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. Electronic address:

Objectives: Bipolar disorder (BD) is a severe mental illness characterized by episodes of mania and depression. Numerous studies have implicated the involvement of endogenous cardiac steroids (CS), and their receptor, Na, K -ATPase, in BD. The aim of the present study was to examine the role of brain oxidative stress in the CS-induced behavioral effects in mice. Read More

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March 2018
5 Reads

Intervention Effect of Repetitive TMS on Behavioral Adjustment After Error Commission in Long-Term Methamphetamine Addicts: Evidence From a Two-Choice Oddball Task.

Neurosci Bull 2018 Jun 16;34(3):449-456. Epub 2018 Jan 16.

Key Laboratory of Cognition and Personality of the Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, 400715, China.

Behavioral adjustment plays an important role in the treatment and relapse of drug addiction. Nonetheless, few studies have examined behavioral adjustment and its plasticity following error commission in methamphetamine (METH) dependence, which is detrimental to human health. Thus, we investigated the behavioral adjustment performance following error commission in long-term METH addicts and how it varied with the application of repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC). Read More

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June 2018
6 Reads

Rewarding effects of physical activity predict sensitivity to the acute subjective effects of d-amphetamine in healthy volunteers.

J Psychopharmacol 2018 Mar 17;32(3):302-308. Epub 2018 Jan 17.

1 Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.

While individual differences in reward sensitivity are believed to generalize across drugs and alternative rewards, this notion has received little empirical attention in human research. Here, we tested whether individual differences in the subjective rewarding effects of physical activity were associated with the subjective response to d-amphetamine administration. Healthy volunteers ( n=95; age 18-35 years) completed questionnaires measuring the self-reported pleasurable effects of physical activity and other covariates, and this was followed by two double-blind counterbalanced sessions during which they received either 20 mg oral d-amphetamine or placebo. Read More

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March 2018
1 Read

The effect of methamphetamine abuse on dental caries and periodontal diseases in an Eastern China city.

BMC Oral Health 2018 01 10;18(1). Epub 2018 Jan 10.

State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.

Background: Dental diseases are among the most frequently reported health problems in drug abusers. However, few studies have been conducted on oral health of methamphetamine (meth) abusers in China. The aim of the present study was to investigate the caries and periodontal health profile of former meth abusers in Eastern China. Read More

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January 2018
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Generalization of effects of environmental enrichment on seeking for different classes of drugs of abuse.

Behav Brain Res 2018 04 27;341:109-113. Epub 2017 Dec 27.

Université de Poitiers, INSERM, U1084, Laboratoire de Neurosciences Experimentales et Cliniques, France. Electronic address:

Background: Addiction is a chronic disease characterized by persistent vulnerability to relapse during abstinence. In animal models of addiction, accumulating evidence suggests that exposure to environmental enrichment (EE) during periods of abstinence can have curative effects on addiction and reduce the risks of relapse. However, until present most studies have mainly focused on cocaine. Read More

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April 2018
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Knowledge and possession of take-home naloxone kits among street-involved youth in a Canadian setting: a cohort study.

Harm Reduct J 2017 12 22;14(1):79. Epub 2017 Dec 22.

British Columbia Centre on Substance Use, 608-1081 Burrard Street, Vancouver, V6Z 1Y6, BC, Canada.

Background: The distribution of take-home naloxone (THN) kits has been an important strategy in reducing overdose fatalities among people who use drugs. However, little is known about the use of THN among youth who are street-involved. The present study explores knowledge and possession of THN among street-involved youth in a Canadian setting. Read More

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December 2017
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Characteristics of Australian adolescent females in residential treatment who report using methamphetamines.

Drug Alcohol Rev 2018 04 21;37 Suppl 1:S384-S393. Epub 2017 Dec 21.

School of Public Health & Community Medicine, UNSW Sydney, Sydney, Australia.

Introduction And Aims: To investigate factors associated with methamphetamine use in adolescent females referred to an Australian residential treatment service.

Design And Methods: A mixed-methods explanatory sequential design was undertaken. Cross-sectional analysis of existing pre-treatment data for adolescent females aged 13-18 years (median 16. Read More

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April 2018
3 Reads

Prior binge-drinking history promotes the positive affective valence of methamphetamine in mice.

Drug Alcohol Depend 2018 02 11;183:150-154. Epub 2017 Dec 11.

Department of Psychological and Brain Sciences, University of California Santa Barbara, Santa Barbara, CA, 93106-9660 USA; Department of Molecular, Cellular and Developmental Biology and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA, 93106-9660 USA. Electronic address:

An alcohol use disorder is a major predisposing factor for methamphetamine (MA) abuse. Further, MA-alcohol co-abuse is a risk factor for treatment discontinuation and non-compliance in MA-dependent individuals. No effective treatment exists for MA addiction, let alone treatments directed at those suffering from MA-alcohol addiction co-morbidity. Read More

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February 2018
8 Reads