2,908 results match your criteria Amphetamine-Related Psychiatric Disorders


Effects of Clavulanic Acid Treatment on Reinstatement to Methamphetamine, Glial Glutamate Transporters, and mGluR 2/3 Expression in P Rats Exposed to Ethanol.

J Mol Neurosci 2019 Jan 23;67(1):1-15. Epub 2018 Nov 23.

College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, University of Toledo, Health Science Campus, 3000 Arlington Avenue, HEB 282G, Toledo, OH, 43614, USA.

Evidence demonstrated that the glutamatergic system is implicated in mediating relapse to several drugs of abuse, including methamphetamine (METH). Glutamate homeostasis is maintained by a number of glutamate transporters, such as glutamate transporter type 1 (GLT-1), cystine/glutamate transporter (xCT), and glutamate aspartate transporter (GLAST). In addition, group II metabotropic glutamate receptors (mGluR2/3) were found to be implicated in relapse-seeking behavior. Read More

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http://dx.doi.org/10.1007/s12031-018-1194-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344243PMC
January 2019
10 Reads

Psychotic Symptoms Associated With Superior Vena Cava Syndrome Following Methamphetamine Abuse.

Prim Care Companion CNS Disord 2018 Nov 1;20(6). Epub 2018 Nov 1.

Department of Psychiatry, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille 13005, Marseille, France.

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http://dx.doi.org/10.4088/PCC.17l02253DOI Listing
November 2018
3 Reads

Neuroimaging of chronic MDMA ("ecstasy") effects: A meta-analysis.

Neurosci Biobehav Rev 2019 01 12;96:10-20. Epub 2018 Nov 12.

University of Basel, Department of Psychiatry (UPK), Switzerland. Electronic address:

In this meta-analysis, we aimed to assess the evidence from neuroimaging studies for chronic alterations in the brains of MDMA users. The databases PubMed, Embase, and Web of Science were searched for studies published from inception to August 24, 2018, without any language restriction. Sixteen independent studies comprising 356 MDMA users and 311 controls were included. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2018.11.004DOI Listing
January 2019
1 Read

Psychiatric Comorbidities among People Who Inject Drugs in Hai Phong, Vietnam: The Need for Screening and Innovative Interventions.

Biomed Res Int 2018 4;2018:8346195. Epub 2018 Oct 4.

Hai Phong University of Medicine and Pharmacy, Hai Phong, Vietnam.

The objective of this study is to describe psychiatric comorbidities, associated factors, and access to psychiatric assessment and care in a cohort of people who inject drugs (PWID) in Hai Phong, Vietnam. Mental health was assessed after 12 months' follow-up using the Mini International Neuropsychiatric Interview questionnaire (MINI 5.0. Read More

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https://www.hindawi.com/journals/bmri/2018/8346195/
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http://dx.doi.org/10.1155/2018/8346195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193349PMC
February 2019
6 Reads

Methamphetamine dependence with and without psychotic symptoms: A multi-modal brain imaging study.

Neuroimage Clin 2018 22;20:1157-1162. Epub 2018 Oct 22.

Department of Psychiatry and MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa. Electronic address:

Objective: Methamphetamine dependence can lead to psychotic symptoms which may be mediated by frontal, striatal, limbic, and thalamic regions. There are few neuroimaging data that allow comparison of individuals with methamphetamine dependence who do, and do not, have psychosis. Two complementary imaging techniques were employed to investigate neurocircuitry associated with methamphetamine dependence with and without psychotic symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183033
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http://dx.doi.org/10.1016/j.nicl.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205927PMC
February 2019
3 Reads

Patterns and sociodemographic characteristics of substance abuse in Al Qassim, Saudi Arabia: a retrospective study at a psychiatric rehabilitation center.

Ann Saudi Med 2018 Sep-Oct;38(5):319-325

Dr. Shalam M. Hussain, Department of Pharmacology and Toxicology,, Unaizah College of Pharmacy,, Qassim University, PO Box 5516,, Unaizah, Saudi Arabia, T: +966-550-911-846, sa, ORCID: http://orcid.org/0000-0002-2398-5485.

Background: The problem of substance abuse is one of the top 20 risk factors for poor health worldwide. Though widely prevalent in the Middle East, there are few studies in Saudi Arabia.

Objective: Record the pattern of substances abuse and the sociodemographic characteristics of abusers attending the local rehabilitation center. Read More

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http://dx.doi.org/10.5144/0256-4947.2018.319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180213PMC
January 2019
3 Reads

Pharmacotherapy for amphetamine dependence: A systematic review.

Drug Alcohol Depend 2018 10 22;191:309-337. Epub 2018 Aug 22.

360Edge Consulting, P.O. Box 359, Elwood, 3184, Victoria, Australia; Department of General Practice, University of Melbourne, 200 Berkeley Street, Carlton, Victoria, 3053, Australia.

Background: Demand for treatment for amphetamine use is increasing internationally. Establishing effective pharmacotherapy provides broader treatment options for people who are dependent on amphetamine and may encourage engagement in evidence-based behavioral treatment. This study aimed to identify medicines that have potential in improving treatment outcomes for people who are dependent on amphetamines. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.06.038DOI Listing
October 2018
4 Reads

[Change of brain structure imaging of long-term withdrawal of methamphetamine-dependent patients].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jan;43(1):41-48

Department of Biomedical Engineering and Radiology,School of Medicine, Wayne State University, Detroit MI 48201, USA.

Objective: To explore the characteristics of brain structure in patients with long-term withdrawal of methamphetamine-dependence.
 Methods: A total of 44 patients with withdrawal of methamphetamine-dependent for more than 14 months were recruited, who met the diagnostic criteria for substance dependence in the fifth edition of the American Mental Disorders Diagnostic and Statistical Manual (DSM-V), and 40 healthy subjects were used as the control. In addition to the general scale of drug-relevant survey, the subjects received the 3. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.01.007DOI Listing
January 2018
15 Reads

Cue reactivity and opioid blockade in amphetamine dependence: A randomized, controlled fMRI study.

Drug Alcohol Depend 2018 10 26;191:91-97. Epub 2018 Jul 26.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Stockholm County Council, Norra Stationsgatan 69, SE-113 64, Stockholm, Sweden.

Background: The opioid antagonist, naltrexone, has been shown to reduce the risk of relapse in amphetamine dependence, but the mechanisms behind this effect are not well understood. We aimed to investigate if naltrexone attenuates cue reactivity and craving in amphetamine dependence.

Methods: Forty men with severe, intravenous amphetamine dependence were randomized to one dose of naltrexone (50 mg) or placebo. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.06.023DOI Listing
October 2018
1 Read

Coronary sinus flow is reduced in methamphetamine abusers: a transthoracic echocardiographic study.

Int J Cardiovasc Imaging 2018 Dec 21;34(12):1889-1894. Epub 2018 Jul 21.

Department of Ultrasound, Jiangsu Province Tumor Hospital, 42 Baiziting Road, Nanjing, 210009, Jiangsu, People's Republic of China.

To compare the coronary sinus flow among healthy participants, methamphetamine abusers without chest pain and those with chest pain. One hundred and eight methamphetamine abusers: 53 ones without chest pain, 55 ones with chest pain, free of ascertained coronary artery disease, were enrolled in this study. A control group of 50 age-matched male healthy participants was studied for comparison. Read More

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http://dx.doi.org/10.1007/s10554-018-1417-yDOI Listing
December 2018
12 Reads

Low-frequency repetitive transcranial magnetic stimulation inhibits the development of methamphetamine-induced conditioned place preference.

Behav Brain Res 2018 11 9;353:129-136. Epub 2018 Jul 9.

Collaborative Innovation Center for Brain Science, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. Electronic address:

The abuse of amphetamine-type stimulants (ATS) has become a global public health issue in recent years, these new-type drugs can cause addiction and serious cognitive impairment. However, there are no effective methods for the prevention and treatment of ATS addiction at present. Repetitive transcranial magnetic stimulation (rTMS) is a painless and non-invasive new therapeutic approach that has been used for the treatment of depression and other neuropsychiatric disorders, but whether it can be used to treat drug addiction is unclear. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.07.004DOI Listing
November 2018
25 Reads

Amphetamine use in the fourth decade of life: Social profiles from a population-based Australian cohort.

Drug Alcohol Rev 2018 09 11;37(6):743-751. Epub 2018 Jul 11.

Centre for Adolescent Health, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.

Introduction And Aims: To estimate the prevalence and frequency of amphetamine use in a cohort of Australians aged in their mid-30s.

Design And Methods: Cross-sectional analysis of wave 10 data collected in 2014 from the Victorian Adolescent Health Cohort Study: a sample of 1435 persons originally selected in a stratified, random community survey of secondary school students from the state of Victoria that commenced in 1992. Weighted multinomial regression models were used to evaluate the social, health and other substance-use correlates of lifetime and current (12-month) amphetamine use and current frequency of use. Read More

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http://doi.wiley.com/10.1111/dar.12840
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http://dx.doi.org/10.1111/dar.12840DOI Listing
September 2018
14 Reads

Simultaneous Determination of Amphetamine-Related New Psychoactive Substances in Urine by Gas Chromatography-Mass Spectrometry.

J Anal Toxicol 2018 Nov;42(9):605-616

Forensic Genetics & Chemistry Division, Supreme Prosecutors' Office, Seoul, Republic of Korea.

Despite the efforts to prevent the spread of new psychoactive substances (NPS) such as synthetic amphetamine derivatives, it is apparent that newer types of NPS are still emerging on the market in recent years. Due to high potential for their abuse, reliable analytical methods are required to determine these substances in biological samples. The objective of this study was to develop and validate the gas chromatography-mass spectrometric (GC-MS) method for the simultaneous determination of 13 amphetamine-related NPS (amphetamine; AP, 4-fluoroamphetamine; 4FA, methamphamine; MA, 4-fluoromethamphetamine; 4FMA, 4-chloroamphetamine; 4CA, para-methoxyamphetamine; PMA, 4-chloromethamphetamine; 4CMA, 6-(2-aminopropyl)benzofuran; 6APB, 4-methylenedioxyamphetamine; MDA, para-methoxymethamphetamine; PMMA, 6-(2-methylaminopropyl)benzofuran; 6MAPB, 3,4-methylenedioxymethamphetamine; MDMA, 5,6-methylenedioxy-2-aminoindane; MDAI) in urine. Read More

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http://dx.doi.org/10.1093/jat/bky037DOI Listing
November 2018
9 Reads

Maximal strength training improves musculoskeletal health in amphetamine users in clinical treatment.

Osteoporos Int 2018 Oct 5;29(10):2289-2298. Epub 2018 Jul 5.

Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Amphetamine use leads to impaired skeletal health and elevated risk of osteoporosis. In the current study, we document that maximal strength training (MST), as a part of clinical treatment, works as a countermeasure, improving muscle force generating capacity, body composition, and skeletal health at sites particularly prone to osteoporotic fractures.

Introduction: Amphetamine users have attenuated musculoskeletal health. Read More

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http://link.springer.com/10.1007/s00198-018-4623-5
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http://dx.doi.org/10.1007/s00198-018-4623-5DOI Listing
October 2018
8 Reads

Limited modulation of the abuse-related behavioral effects of d-methamphetamine by disulfiram.

Exp Clin Psychopharmacol 2018 Oct 2;26(5):497-502. Epub 2018 Jul 2.

Preclinical Pharmacology Laboratory, McLean Hospital.

Disulfiram (Antabuse), an acetaldehyde dehydrogenase and dopamine-beta hydroxylase inhibitor, has shown promise in preclinical and clinical studies as a pharmacotherapy for cocaine addiction. However, the extent to which disulfiram may alter the abuse-related behavioral effects of related psychostimulants, such as methamphetamine, is unknown. Here, the therapeutic potential of disulfiram was evaluated by examining its impact on the reinforcing and discriminative stimulus effects of d-methamphetamine in adult rhesus monkeys (N = 4 per group). Read More

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http://dx.doi.org/10.1037/pha0000222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162099PMC
October 2018
16 Reads

Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse.

PLoS One 2018 29;13(6):e0200060. Epub 2018 Jun 29.

Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.

Methamphetamine (METH) substance abuse disorders have major impact on society, yet no medications have proven successful at preventing METH relapse or cravings. Anti-METH monoclonal antibodies can reduce METH brain concentrations; however, this therapy has limitations, including the need for repeated dosing throughout the course of addiction recovery. An adeno-associated viral (AAV)-delivered DNA sequence for a single-chain variable fragment could offer long-term, continuous expression of anti-METH antibody fragments. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200060PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025879PMC
December 2018
3 Reads

Individualized texting for adherence building (iTAB) for methamphetamine users living with HIV: A pilot randomized clinical trial.

Drug Alcohol Depend 2018 08 21;189:154-160. Epub 2018 Jun 21.

Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.

Background: Methamphetamine (METH) use poses a barrier to antiretroviral therapy (ART) adherence. We evaluated the efficacy of the individualized texting for adherence building (iTAB) intervention among persons living with HIV (PLWH) who meet criteria for METH use disorder. We examined daily associations between ART adherence and text-reported METH use and depressed mood. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324532PMC
August 2018
3 Reads

Office-Based Addiction Treatment in Primary Care: Approaches That Work.

Med Clin North Am 2018 Jul;102(4):635-652

Department of Internal Medicine, Yale University School of Medicine, 367 Cedar Street, Suite 305, New Haven, CT 06510, USA.

Primary care is an important setting for delivering evidence-based treatment to address substance use disorders. To date, effective approaches to treat, care largely incorporate pharmacotherapy with counseling-based interventions and rely on multidisciplinary teams. There is strong support for primary care-based approaches to address alcohol and opioid use disorder with growing data focused on people living with human immunodeficiency virus and those experiencing incarceration. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.02.007DOI Listing
July 2018
5 Reads

Varenicline treatment for methamphetamine dependence: A randomized, double-blind phase II clinical trial.

Drug Alcohol Depend 2018 08 25;189:30-36. Epub 2018 May 25.

Department of Family Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Background: Previous studies have suggested that varenicline, an α4β2 nicotinic receptor partial agonist, and α7 nicotinic receptor full agonist, may be effective for the treatment of methamphetamine (MA) dependence due to dopaminergic effects, relief of glutamatergic and cognitive dysfunction, and activation of nicotinic cholinergic systems. This study aimed to determine if varenicline (1 mg BID) resulted in reduced methamphetamine use compared to placebo among treatment-seeking MA-dependent volunteers.

Methods: Treatment-seeking MA-dependent volunteers were randomized to varenicline 1 mg twice daily (n = 27) or placebo (n = 25) and cognitive behavioral therapy for 9 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03768716183028
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http://dx.doi.org/10.1016/j.drugalcdep.2018.04.023DOI Listing
August 2018
19 Reads

Association between cytochrome P450 2D6 polymorphisms and body fluid methamphetamine concentrations in Japanese forensic autopsy cases.

Forensic Sci Int 2018 Aug 18;289:33-39. Epub 2018 May 18.

Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan.

Methamphetamine (MA) is an illicit stimulant that affects the central nervous system. Cytochrome P450 2D6 (CYP2D6) plays an important role in MA metabolism. Numerous allelic variants confer substantial variation in CYP2D6 activity among individuals. Read More

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http://dx.doi.org/10.1016/j.forsciint.2018.05.018DOI Listing
August 2018
10 Reads

False-positive amphetamine results on several drug screening platforms due to mexiletine.

Clin Biochem 2018 Aug 23;58:125-127. Epub 2018 May 23.

Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, United States.

Objective: False-positive urine drug of abuse screening (UDS) results can have serious implications in clinical practice, particularly when confirmation assay results are not immediately available to providers making medical decisions. Often it is not possible to identify the specific medication or other interfering compound that is responsible for the false-positive UDS result. Even when a potential interference is reported in the literature or package insert for one assay, the applicability to other UDS platforms/assays is often unknown. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2018.05.013DOI Listing
August 2018
9 Reads

Comparative hazards of acute myocardial infarction among hospitalized patients with methamphetamine- or cocaine-use disorders: A retrospective cohort study.

Drug Alcohol Depend 2018 07 26;188:259-265. Epub 2018 Apr 26.

Human Brain Laboratory, Centre for Addiction and Mental Health (CAMH), 33 Russell St., Toronto, ON M5S 2S1, Canada.

Background: It is assumed that recreational use of methamphetamine can trigger acute myocardial infarction (AMI) events, but estimates of longitudinal hazards of AMI among methamphetamine users are lacking.

Methods: Retrospective cohort study: Competing-risks analysis was used to estimate time-to-AMI patterns in methamphetamine versus matched appendicitis (population-proxy) and matched cocaine (drug-control) groups. Cohorts were propensity-score-matched using demographic and clinical variables. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.03.030DOI Listing
July 2018
6 Reads

Methamphetamine consumption and life-threatening abdominal complications: A case report.

Medicine (Baltimore) 2018 May;97(18):e0647

Department of Critical Care Medicine.

Rationale: Methamphetamine (METH) abuse is increasing rapidly all over the world and becoming a significant public health concern in China. However, abdominal complications secondary to METH abuse are usually overlooked. We describe an unusual case of gangrenous cholecystitis and small intestinal ischemia due to METH abuse. Read More

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http://dx.doi.org/10.1097/MD.0000000000010647DOI Listing
May 2018
7 Reads

Relationship between the duration of methamphetamine use and psychotic symptoms: A two-year prospective cohort study.

Drug Alcohol Depend 2018 06 22;187:363-369. Epub 2018 Apr 22.

National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China; Institute of Mental Health, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health and Peking University Sixth Hospital, Peking University, Beijing, 100191, China; Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100191, China. Electronic address:

Background: Psychosis is a key harm associated with methamphetamine (MA) use. This study examined the relationship between the duration of MA use and risk of psychotic symptoms.

Methods: A cohort of 528 individuals with chronic MA use was followed for two years after leaving treatment center in Guangdong, China. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.03.023DOI Listing
June 2018
8 Reads

Age- and sex-dependent effects of methamphetamine on cognitive flexibility and 5-HT receptor localization in the orbitofrontal cortex of Sprague-Dawley rats.

Behav Brain Res 2018 09 30;349:16-24. Epub 2018 Apr 30.

Department of Psychology, University of Illinois, Urbana-Champaign, 603 E. Daniel St., Champaign, IL, 61820, USA; Neuroscience Program, University of Illinois, Urbana-Champaign, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA. Electronic address:

Adolescents and females experience worse outcomes of drug use compared to adults and males. This could result from age- and sex-specific consequences of drug exposure on brain function and cognitive behavior. In the current study, we examined whether a history of intravenous methamphetamine (METH) self-administration impacted cognitive flexibility and 5-HTR localization in the orbitofrontal cortex (OFC) in an age- and sex-dependent manner. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.04.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993617PMC
September 2018
6 Reads

High-frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex restores attention bias to negative information in methamphetamine addicts.

Psychiatry Res 2018 07 21;265:151-160. Epub 2018 Apr 21.

The Laboratory for Affect Cognition and Regulation, Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing,400715, China. Electronic address:

Methamphetamine (hereafter, meth) addiction results in various emotional problems linked to structural impairments in the prefrontal cortex (PFC). In this paper, we investigated whether high-frequency (10 Hz) repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral PFC (DLPFC) can improve emotional attention. Thirty-one meth addicts were randomly assigned to a 10 Hz or sham rTMS group; additionally, 31 healthy participants were enrolled, who were required to respond as correctly and quickly as possible to a yellow arrow embedded in an image depicting emotional content (neutral, fear, sadness, or disgust). Read More

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http://dx.doi.org/10.1016/j.psychres.2018.04.039DOI Listing
July 2018
2 Reads
2.470 Impact Factor

Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice.

Behav Brain Res 2018 09 27;349:73-79. Epub 2018 Apr 27.

Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA.

Mild neurocognitive impairments are common in people with human immunodeficiency virus (HIV) infection. HIV-encoded proteins, such as trans-activator of transcription (TAT), contribute to neuropathology and cognitive function in medicated subjects. The combination of TAT and comorbid methamphetamine use may further impair neurocognitive function in HIV-positive individuals by affecting dopaminergic systems in the brain. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.04.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320247PMC
September 2018
3 Reads

Cognitive deficit in methamphetamine users relative to childhood academic performance: link to cortical thickness.

Neuropsychopharmacology 2018 07 20;43(8):1745-1752. Epub 2018 Apr 20.

Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience, David Geffen School of Medicine, Los Angeles, CA, 90024, USA.

Individuals with cognitive problems may be predisposed to develop substance use disorders; therefore, differences in cognitive function between methamphetamine users and control participants may be attributable to premorbid factors rather than methamphetamine use. The goal of this study was to clarify the extent to which this is the case. Childhood academic transcripts were obtained for 37 methamphetamine-dependent adults and 41 control participants of similar educational level and premorbid IQ. Read More

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http://dx.doi.org/10.1038/s41386-018-0065-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006320PMC

The relationship between illicit amphetamine use and psychiatric symptom profiles in schizophrenia and affective psychoses.

Psychiatry Res 2018 07 5;265:19-24. Epub 2018 Apr 5.

National Centre for Epidemiology and Population Health, Australian National University, Building 62, Mills Road, Acton, ACT 2601, Australia; National Drug and Alcohol Research Centre, University of New South Wales, 22-32 King Street, Randwick, NSW 2031, Australia.

This study examines whether illicit amphetamine use is associated with differences in the prevalence of specific psychiatric symptoms in a community sample of individuals diagnosed with schizophrenia or affective psychotic disorders. Data was drawn from the Australian Survey of High Impact Psychosis. The Diagnostic Interview for Psychosis was used to measure substance use and psychiatric symptoms. Read More

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https://www.researchgate.net/profile/Alexandra_Voce/publicat
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https://www.researchgate.net/publication/44631818_Treating_c
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https://linkinghub.elsevier.com/retrieve/pii/S01651781173198
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http://dx.doi.org/10.1016/j.psychres.2018.04.015DOI Listing
July 2018
5 Reads

Rocuronium for control of muscle spasms in a tetanus patient with chronic methamphetamine use disorder.

BMJ Case Rep 2018 Apr 10;2018. Epub 2018 Apr 10.

Department of Neurosciences, University of the Philippines-Philippine General Hospital, Manila, Philippines.

This is a case of a 31-year-old Filipino man with chronic methamphetamine use disorder who developed tetanus from a necrotic skin graft over his left calcaneus, which was fractured after a motor vehicular accident. During the course of his illness, the patient's muscle spasms were unusually refractory to benzodiazepine, which is the first-line drug used in the management of muscle spasms. The muscle spasms were successfully controlled on the seventh day of illness with rocuronium at a dose of 10 μg/kg/min and midazolam at 0. Read More

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http://dx.doi.org/10.1136/bcr-2018-224391DOI Listing
April 2018
17 Reads

Brain Activity during Methamphetamine Anticipation in a Non-Invasive Self-Administration Paradigm in Mice.

eNeuro 2018 Mar-Apr;5(2). Epub 2018 Apr 6.

Department of Psychology, Barnard College, New York, NY 10027.

The ability to sense time and anticipate events is critical for survival. Learned responses that allow anticipation of the availability of food or water have been intensively studied. While anticipatory behaviors also occur prior to availability of regularly available rewards, there has been relatively little work on anticipation of drugs of abuse, specifically methamphetamine (MA). Read More

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http://dx.doi.org/10.1523/ENEURO.0433-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889482PMC
January 2019
5 Reads

The relationship between impulsivity and methamphetamine use severity in a community sample.

Drug Alcohol Depend 2018 06 27;187:1-7. Epub 2018 Mar 27.

Department of Psychology, University of California, Los Angeles, United States. Electronic address:

Background: Abuse of psychostimulants, including methamphetamine (MA), has been linked to heightened impulsivity. While previous research has demonstrated differences in impulsivity between MA users and non-substance users, less is known about variability in impulsivity within MA users and whether the severity of MA use related problems predicts impulsivity within individuals who regularly use MA. This study aims to elucidate the relationship between impulsivity and MA use severity. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.01.034DOI Listing
June 2018
5 Reads

Impact of aerobic exercise on cognitive impairment and oxidative stress markers in methamphetamine-dependent patients.

Psychiatry Res 2018 08 17;266:328-333. Epub 2018 Mar 17.

Collaborative Innovation Center for Brain Science, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. Electronic address:

This study aimed to investigate whether 12-week moderate-intensity aerobic exercise has beneficial effects on oxidative stress markers in blood and on cognitive functions in patients who have methamphetamine dependence. Serum levels of oxidative stress markers, including total anti-oxidation capability, super oxide dismutase (SOD), catalase (CAT), and methane dicarboxylic aldehyde (MDA), were measured at baseline (all participants) and the 12-week follow-up (methamphetamine-dependent patients). Serum levels of CAT and MDA in methamphetamine-dependent patients (n = 68) were higher than those in healthy controls (n = 35) at baseline. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.03.032DOI Listing
August 2018
6 Reads
1 Citation
2.470 Impact Factor

Neural activation to monetary reward is associated with amphetamine reward sensitivity.

Neuropsychopharmacology 2018 07 14;43(8):1738-1744. Epub 2018 Mar 14.

Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.

One known risk factor for drug use and abuse is sensitivity to rewarding effects of drugs. It is not known whether this risk factor extends to sensitivity to non-drug rewards. In this study with healthy young adults, we examined the association between sensitivity to the subjective rewarding effects of amphetamine and a neural indicator of anticipation of monetary reward. Read More

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http://dx.doi.org/10.1038/s41386-018-0042-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006344PMC
July 2018
1 Read

Prescription drug diversion is becoming a lucrative business in regional and rural Australian communities and is escalating due to methamphetamine withdrawal.

Int J Ment Health Nurs 2018 Apr;27(2):467-469

School of Health, University of New England, Armidale, NSW, Australia.

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http://doi.wiley.com/10.1111/inm.12458
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http://dx.doi.org/10.1111/inm.12458DOI Listing
April 2018
2 Reads

Atomoxetine for amphetamine-type stimulant dependence during buprenorphine treatment: A randomized controlled trial.

Drug Alcohol Depend 2018 05 10;186:130-137. Epub 2018 Mar 10.

Centre for Drug Research, Universiti Sains Malaysia, 11800, Penang, Malaysia.

Background: Amphetamine type stimulants (ATS) use is highly prevalent and frequently co-occurs with opioid dependence in Malaysia and Asian countries. No medications have established efficacy for treating ATS use disorder. This study evaluated the safety, tolerability, and potential efficacy of atomoxetine for treating ATS use disorder. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911201PMC
May 2018
8 Reads
3.423 Impact Factor

A commentary on the effects of methamphetamine and the status of methamphetamine abuse among youths in South Korea, Japan, and China.

Forensic Sci Int 2018 May 26;286:81-85. Epub 2018 Feb 26.

College of Pharmacy, Duksung Women's University, Seoul, South Korea. Electronic address:

Methamphetamine (MA) abuse continues in East Asia and shows an increasing trend among youths in South Korea, Japan, and China. Although the negative effects of MA abuse on youth are considered as significant problems, few studies have been conducted on the topic in these countries. This paper focuses on the effects of MA on the human body and current MA abuse among youths in South Korea, Japan, and China. Read More

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http://dx.doi.org/10.1016/j.forsciint.2018.02.022DOI Listing
May 2018
5 Reads

Increasing amphetamine use and forensic involvement among clients of three residential Indigenous alcohol and other drug services in Victoria, Australia.

Drug Alcohol Rev 2018 Jul 21;37(5):671-675. Epub 2018 Mar 21.

Department of Allied and Community Health, La Trobe University, Melbourne, Australia.

Introduction And Aims: Indigenous people seeking residential alcohol and other drug (AOD) rehabilitation in Victoria are most frequently referred to the Ngwala Willumbong Co-operative (Ngwala). This study aimed to describe socio-demographic changes in clients of Ngwala's residential rehabilitation services between 2015 and 2016.

Design And Methods: Self-assessment surveys completed upon screening for rehabilitation between May 2015 and November 2016 (n = 117) were analysed for socio-demographic data, AOD use and mental health status. Read More

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http://dx.doi.org/10.1111/dar.12692DOI Listing
July 2018
1 Read

Amphetamine availability predicts amphetamine-related mental health admissions: A time series analysis.

Aust N Z J Psychiatry 2018 Nov 19;52(11):1050-1056. Epub 2018 Mar 19.

5 National Drug & Alcohol Research Centre, University of NSW Sydney, Sydney, NSW, Australia.

Objective:: Amphetamine use and availability have increased in Australia and there are concerns that this has led to more frequent hospital admissions with amphetamine-related psychosis. This study examines whether amphetamine-related admissions to mental health units are more common at times of greater amphetamine availability.

Methods:: We conducted an ecological study using aggregate crime and health service data for NSW, Australia, from January 2000 to March 2015. Read More

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http://dx.doi.org/10.1177/0004867418763538DOI Listing
November 2018
6 Reads

Role of AMPA glutamate receptors in the conditioned rewarding effects of MDMA in mice.

Behav Brain Res 2018 07 8;347:57-60. Epub 2018 Mar 8.

Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universidad de Valencia, Spain. Electronic address:

Currently, there is not an effective treatment for 3,4-methylenedioxymethamphetamine (MDMA) dependence but pharmacotherapies targeting glutamate neurotransmission are a promising strategy. Previously, we showed that blockade of glutamate NMDA and AMPA receptors impairs the conditioned rewarding effects of MDMA and cocaine, respectively. In this study we evaluated the role of AMPA receptors in the rewarding effects of MDMA in mice using the conditioned place preference (CPP) paradigm. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.03.010DOI Listing
July 2018
2 Reads

Opioids and methamphetamine: a tale of two crises.

Authors:
The Lancet

Lancet 2018 02;391(10122):713

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http://dx.doi.org/10.1016/S0140-6736(18)30319-2DOI Listing
February 2018
3 Reads

Cross-sectional cause of death comparisons for stimulant and opioid mortality in San Francisco, 2005-2015.

Drug Alcohol Depend 2018 04 21;185:305-312. Epub 2018 Feb 21.

San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 500, San Francisco, CA, United States; Department of Medicine, Division of HIV, Infectious Disease and Global Health, University of California, San Francisco, CA, United States.

Background: Opioids and stimulants (e.g., cocaine or methamphetamine/amphetamine [MAMP]) are major contributors to acute substance toxicity deaths. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2017.12.030DOI Listing
April 2018
10 Reads

Crystal methamphetamine use and its correlates in women engaged in sex work in a developing country setting.

Drug Alcohol Depend 2018 04 14;185:260-265. Epub 2018 Feb 14.

HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran; Department of Epidemiology and Biostatistics and Institute for Global Health Sciences, University of California San Francisco, 550 16th St., San Francisco, CA, USA. Electronic address:

Background: Worldwide, crystal methamphetamine (CM) use and associated high-risk sexual behaviors are a concern, but they are less studied among female sex workers (FSW) in developing countries. This study aimed to characterize the prevalence and individual, interpersonal, and structural correlates of self-reported past-month CM use among FSW in Iran.

Methods: FSW aged ≥ 18 years who reported penetrative sex with more than one client in the last year were recruited (analytic sample: 1295). Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2017.12.025DOI Listing
April 2018
3 Reads

Distress and sleep quality in young amphetamine-type stimulant users with an affective or psychotic illness.

Psychiatry Res 2018 04 17;262:254-261. Epub 2018 Feb 17.

Youth Mental Health Team, Brain and Mind Centre, University of Sydney, NSW, Australia; Sunshine Coast Mind and Neuroscience Thompson Institute, University of the Sunshine Coast, QLD, Australia.

Misuse of amphetamine-type stimulant (ATS) drugs may disrupt key neurodevelopmental processes in young people and confer protracted neurocognitive and psychopathological harm. ATS users with a co-occurring psychiatric illness are typically excluded from research, reducing generalisability of findings. Accordingly, we conducted a cross-sectional examination of key clinical, sleep, socio-occupational and neurocognitive measures in current, past and never users of ATS drugs who were accessing a youth mental health service (headspace) for affective- or psychotic-spectrum illnesses. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.02.033DOI Listing
April 2018
10 Reads

The impact of acute and short-term methamphetamine abstinence on brain metabolites: A proton magnetic resonance spectroscopy chemical shift imaging study.

Drug Alcohol Depend 2018 04 22;185:226-237. Epub 2018 Feb 22.

Department of Psychiatry and Mental Health, Groote Schuur Hospital, University of Cape Town, Anzio Rd., Observatory, 7925 Cape Town, South Africa; Neuroscience Institute, University of Cape Town, South Africa.

Background: Abuse of methamphetamine (MA) is a global health concern. Previous H-MRS studies have found that, with methamphetamine abstinence (MAA), there are changes in n-acetyl-aspartate (NAA/Cr), myo-inositol (mI/Cr), choline (Cho/Cr and Cho/NAA), and glutamate with glutamine (Glx) metabolites. Limited studies have investigated the effect of acute MAA, and acute-to-short-term MAA on brain metabolites. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2017.11.029DOI Listing
April 2018
4 Reads
3.420 Impact Factor

Olanzapine and haloperidol for the treatment of acute symptoms of mental disorders induced by amphetamine-type stimulants: A randomized controlled trial.

Medicine (Baltimore) 2018 Feb;97(8):e9786

Department of Substance Abuse, Shandong Mental Health Center, Jinan, China.

Background: This study aimed to compare olanzapine and haloperidol efficacies in the treatment of acute psychiatric symptoms due to amphetamine-type stimulants (ATSs).

Methods: The Zelen II design method was used; 124 patients with acute mental disorders due to amphetamine were randomly divided into olanzapine group (n = 63) and haloperidol group (n = 61). Then, a 4-week open-label medical therapy was performed. Read More

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http://dx.doi.org/10.1097/MD.0000000000009786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842020PMC
February 2018
10 Reads

Neural responses to cues paired with methamphetamine in healthy volunteers.

Neuropsychopharmacology 2018 07 30;43(8):1732-1737. Epub 2018 Jan 30.

Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.

Drug cues, or conditioned responses to stimuli paired with drugs, are widely believed to promote drug use. The acquisition of these conditioned responses has been well characterized in laboratory animals: neutral stimuli paired with drugs elicit conditioned responses resembling the motivational and incentive properties of the drug itself. However, few studies have examined acquisition of conditioning, or the nature of the conditioned response, in humans. Read More

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http://dx.doi.org/10.1038/s41386-017-0005-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006246PMC
July 2018
5 Reads

Profile of psychiatric symptoms in methamphetamine users in China: Greater risk of psychiatric symptoms with a longer duration of use.

Psychiatry Res 2018 04 5;262:184-192. Epub 2018 Feb 5.

National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China; Peking University Sixth Hospital, Peking University Institute of Mental Health, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health, Peking University, Beijing 100191, China; Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100191, China. Electronic address:

Chronic methamphetamine (MA) use is associated with psychiatric symptoms. This study explored pattern of co-occurring psychiatric symptoms in MA users and their relationship to duration of MA use. A cross-sectional study was conducted among MA users at the Shenzhen Compulsory Drug Detoxification Center from April 2012 to October 2015. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.02.017DOI Listing
April 2018
7 Reads