111 results match your criteria Amme Idaresi Dergisi[Journal]


Radiographic Evaluation of Bone Remodeling Around Osseointegration Implants Among Transfemoral Amputees.

J Orthop Trauma 2019 Apr 9. Epub 2019 Apr 9.

The Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW 2109, Australia.

Objectives: To examine periprosthetic bone remodeling among the recipients of two types of lower-limb osseointegrated systems, the Integral Leg Prosthesis (ILP) and the Osseointegration Prosthetic Limb Type-A (OPL), over a > 24-month period.

Design: Retrospective cohort study.

Setting: Private hospital, with a specialized osseointegration unit. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001488DOI Listing

Thermal induced deflection of a porcelain-zirconia bilayer: Influence of cooling rate.

Dent Mater 2019 Apr 7;35(4):574-584. Epub 2019 Feb 7.

Vita Zahnfabrik GmbH, Bad Sachingen, Germany.

Objective: To determine the thermal expansion of a porcelain (VM9) and tetragonal zirconia (Y-TZP) as well as the deflection upon re-heating and cooling of a bilayer fabricated from these two materials after slow and rapid cooling during initial fabrication.

Methods: The coefficient of thermal expansion (CTE) of bulk porcelain and Y-TZP as well as bilayer beam deflection was measured with a novel non-contact optical dilatometer. The influence of cooling rate during initial fabrication of the porcelain-zirconia bilayer and the bulk porcelain during subsequent heating and cooling is investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01095641183062
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http://dx.doi.org/10.1016/j.dental.2019.01.019DOI Listing
April 2019
1 Read

Xq22.3q23 microdeletion harboring TMEM164 and AMMECR1 genes: Two case reports confirming a recognizable phenotype with short stature, midface hypoplasia, intellectual delay, and elliptocytosis.

Am J Med Genet A 2019 Apr 8;179(4):650-654. Epub 2019 Feb 8.

Département de Génétique et Procréation, Centre Hospitalo-Universitaire Grenoble Alpes, Grenoble Cedex, France.

The AMME syndrome defined as the combination of Alport syndrome, intellectual disability, midface hypoplasia, and elliptocytosis (AMME) is known to be a contiguous gene syndrome associated with microdeletions in the region Xq22.3q23. Recently, using exome sequencing, missense pathogenic variants in AMMECR1 have been associated with intellectual disability, midface hypoplasia, and elliptocytosis. Read More

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http://dx.doi.org/10.1002/ajmg.a.61057DOI Listing
April 2019
1 Read

Novel injectable strontium-hardystonite phosphate cement for cancellous bone filling applications.

Mater Sci Eng C Mater Biol Appl 2019 Apr 30;97:103-115. Epub 2018 Nov 30.

Biomaterials and Tissue Engineering Unit, School of AMME, Faculty of Engineering and IT, University of Sydney, NSW 2006, Australia; Joint Bioengineering and Regenerative Medicine Lab, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China. Electronic address:

Injectable bone cement (IBC) such as those based on methacrylates and hydraulic calcium phosphate and calcium sulfate-based cements have been used extensively for filling bone defects with acceptable clinical outcomes. There is a need however for novel IBC materials that can address some of the inherent limitations of currently available formulations to widen the clinical application of IBC. In this study, we characterized a novel hydraulic IBC formulation consisting of bioactive strontium-doped hardystonite (Sr-HT) ceramic microparticles and sodium dihydrogen phosphate, herein named Sr-HT phosphate cement (SPC). Read More

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http://dx.doi.org/10.1016/j.msec.2018.11.069DOI Listing

Triple-Bioinspired Burying/Crosslinking Interfacial Coassembly Strategy for Layer-by-Layer Construction of Robust Functional Bioceramic Self-Coatings for Osteointegration Applications.

ACS Appl Mater Interfaces 2019 Jan 17;11(4):4447-4469. Epub 2019 Jan 17.

Department of Materials Science and Engineering, College of Engineering , Peking University , Beijing 100871 , China.

Coating bioceramics of inherent bioactivity onto biometallic implants is a straightforward yet promising solution to address poor osteointegration of the latter. One step further, it would be a nontrivial accomplishment to develop a mild, cheap, and universal route to firmly stabilizing, in principle, any ceramics onto any implant substrate, while imparting expectedly versatile biofunctional performances. Herein, we describe a triple-bioinspired burying/cross-linking interfacial coassembly strategy for enabling such ceramic coatings, which ingeniously fuses bioinspiration from sea rocks (burying assisted particle immobilization), marine mussels (universal adhesion and versatile chemical reactivity), and reef-building oysters (cross-linking rendered cohesion). Read More

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http://dx.doi.org/10.1021/acsami.8b20429DOI Listing
January 2019
2 Reads

Modulatory effect of simultaneously released magnesium, strontium, and silicon ions on injectable silk hydrogels for bone regeneration.

Mater Sci Eng C Mater Biol Appl 2019 Jan 15;94:976-987. Epub 2018 Oct 15.

Biomaterials and Tissue Engineering Research Unit, School of AMME, Faculty of Engineering and IT, University of Sydney, Sydney, Australia. Electronic address:

Injectable silk hydrogels are ideal carriers of therapeutic agents due to their biocompatibility and low immunogenicity. Injectable silk hydrogels for bone regeneration have been previously developed but often utilize expensive biologics. In this study, we have developed an injectable silk composite incorporated with a triphasic ceramic called MSM-10 (54 MgSiO, 36 SiSr and 10 MgO (wt%)) capable of simultaneously releasing magnesium, silicon, and strontium ions into its environment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931173470
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http://dx.doi.org/10.1016/j.msec.2018.10.053DOI Listing
January 2019
9 Reads

Frictional coefficient during flossing of teeth.

Dent Mater 2018 12 21;34(12):1727-1734. Epub 2018 Sep 21.

AMME, Sydney University, Sydney, Australia. Electronic address:

Objective: This in-vitro study aimed to develop a technique to measure the frictional forces and determine the frictional coefficient (μ) associated with the rubbing of dental floss against teeth. Incorrect flossing technique and the etiology of grooves at the cementoenamel junction (CEJ) of proximal area of teeth has long been a controversial topic. We hypothesized that the μ between teeth surfaces and dental floss is affected by contact angulation. Read More

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http://dx.doi.org/10.1016/j.dental.2018.09.002DOI Listing
December 2018
3 Reads

Influence of ageing on glass and resin bonding of dental glass-ceramic veneer adhesion to zirconia: A fracture mechanics analysis and interpretation.

Acta Biomater 2018 07 26;74:454-463. Epub 2018 Apr 26.

Faculty of Dentistry, The University of Otago, Dunedin, New Zealand. Electronic address:

Adhesion plays a major role in the bonding of dental materials. In this study the adhesion of two glass-ceramic systems (IPS e.max and VITABLOCS) to a zirconia sintered substrate using a glass (for IPS e. Read More

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http://dx.doi.org/10.1016/j.actbio.2018.04.049DOI Listing
July 2018
3 Reads

Clinically Relevant Outcome Measures Following Limb Osseointegration; Systematic Review of the Literature.

J Orthop Trauma 2018 02;32(2):e64-e75

OP Solutions, Tampa, FL.

Objectives: The current standard of care for an amputee is a socket-based prostheses. An osseointegrated implant (OI) is an alternative for prosthetic attachment. Osseointegration addresses reported problems related to wearing a socket interface, such as skin issues, discomfort, diminished function, quality of life, prosthetic use, and abandonment. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001031DOI Listing
February 2018
7 Reads

Sydney Nano: small matters for big impact.

Biophys Rev 2018 Feb 10;10(1):101-103. Epub 2018 Jan 10.

The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, Camperdown, NSW, 2006, Australia.

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http://link.springer.com/10.1007/s12551-017-0386-z
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http://dx.doi.org/10.1007/s12551-017-0386-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803179PMC
February 2018
1 Read

Slow-growing amelanotic malignant melanoma of the esophagus with long survival: a case report and review of the literature.

Endosc Int Open 2017 Nov 27;5(11):E1076-E1080. Epub 2017 Oct 27.

Department of Endoscopy, Aichi Cancer Center Hospital, Aichi, Japan.

 We report a case of amelanotic malignant melanoma of the esophagus (AMME), an exceedingly rare disease. A 77-year-old Japanese woman presented to our hospital with features suggestive of a middle esophageal submucosal tumor, which was diagnosed pathologically as AMME. The patient underwent thoracoscopic resection of the esophagus and laparoscopic gastric tube reconstruction. Read More

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http://dx.doi.org/10.1055/s-0043-117951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659865PMC
November 2017
6 Reads

Measurement of physical activity in the pre- and early post-operative period after total knee arthroplasty for Osteoarthritis using a Fitbit Flex device.

Med Eng Phys 2018 01 6;51:31-40. Epub 2017 Nov 6.

North Sydney Orthopaedic & Sports Medicine Centre, Mater Hospital, NSW 2065, Australia. Electronic address:

Total knee arthroplasty (TKA) is a standard treatment for patients with end stage knee Osteoarthritis (OA) to reduce pain and restore function. The aim of this study was to assess pre- and early post-operative physical activity (PA) with Fitbit Flex devices for patients with OA undergoing TKA and determine any benchmarks for expected post-operative activity. Significant correlations of pre-operative step count, post-operative step count, Body Mass Index (BMI) and Short Form 12 Physical Component Summaries (SF-12 PCS) were found. Read More

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http://dx.doi.org/10.1016/j.medengphy.2017.10.007DOI Listing
January 2018
2 Reads

Extrinsic Parameter Calibration for Line Scanning Cameras on Ground Vehicles with Navigation Systems Using a Calibration Pattern.

Sensors (Basel) 2017 Oct 30;17(11). Epub 2017 Oct 30.

The Australian Centre for Field Robotics (ACFR), Department of Aerospace, Mechanical and Mechatronic Engineering (AMME), The University of Sydney, Sydney, NSW 2006, Australia.

Line scanning cameras, which capture only a single line of pixels, have been increasingly used in ground based mobile or robotic platforms. In applications where it is advantageous to directly georeference the camera data to world coordinates, an accurate estimate of the camera's 6D pose is required. This paper focuses on the common case where a mobile platform is equipped with a rigidly mounted line scanning camera, whose pose is unknown, and a navigation system providing vehicle body pose estimates. Read More

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http://dx.doi.org/10.3390/s17112491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712799PMC
October 2017

Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling.

Bone Res 2017 5;5:17023. Epub 2017 Sep 5.

Bone Research Program, ANZAC Research Institute, Sydney, New South Wales, Australia.

Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)D] are mediated through binding to the vitamin D receptor (VDR). Here, we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation Implantation of these VDR knockdown cells into the mammary fat pad (MDA-MB-231), subcutaneously (PC3) or intra-tibially (both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls. Read More

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http://dx.doi.org/10.1038/boneres.2017.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605769PMC
September 2017
23 Reads

Patient Variation Limits Use of Fixed References for Femoral Rotation Component Alignment in Total Knee Arthroplasty.

J Arthroplasty 2018 01 24;33(1):67-74. Epub 2017 Aug 24.

Department of Biomedical Engineering, AMME, University of Sydney, Sydney, New South Wales, Australia.

Background: Optimal rotational alignment of the femoral component is a common goal during total knee arthroplasty. The posterior condylar axis (PCA) is thought to be the most reproducible reference in surgery, while the transepicondylar axis (TEA) seems to better approximate the native kinematic flexion axis. This study sought to determine if rules based on patient gender or coronal alignment could allow reliable reproduction of the TEA from the PCA. Read More

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http://dx.doi.org/10.1016/j.arth.2017.08.023DOI Listing
January 2018
2 Reads

Osseointegrated Transtibial Implants in Patients with Peripheral Vascular Disease: A Multicenter Case Series of 5 Patients with 1-Year Follow-up.

J Bone Joint Surg Am 2017 Sep;99(18):1516-1523

1Department of Surgery (R.A.), Physical Therapy, Department of Orthopaedics (R.L.), and Osseointegration, Department of Surgery (P.F.), Radboud University Medical Center, Nijmegen, the Netherlands 2Biomaterials and Tissue Engineering Research Unit, School of AMME, University of Sydney, Sydney, New South Wales, Australia 3Australian School of Advanced Medicine, Macquarie University, North Ryde, New South Wales, Australia 4School of Medicine, The University of Notre Dame Australia, Auburn, New South Wales, Australia 5Norwest Private Hospital, Bella Vista, New South Wales, Australia.

Background: Osseointegration is an alternative treatment for amputees who are unable to wear or have difficulty wearing a socket prosthesis. Although the majority of limb amputations are due to vascular disease, such amputations have been perceived as a contraindication to osseointegration surgery. We report the outcomes of osseointegrated reconstruction in a series of 5 patients with limb amputation due to peripheral vascular disease. Read More

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http://dx.doi.org/10.2106/JBJS.16.01295DOI Listing
September 2017
20 Reads

A New Approach to Understand the Adsorption of Thiophene on Different Surfaces: An Atom Probe Investigation of Self-Assembled Monolayers.

Langmuir 2017 09 5;33(38):9573-9581. Epub 2017 Sep 5.

AMME and Australian Centre for Microscopy and Microanalysis, The University of Sydney , Sydney, New South Wales 2006, Australia.

Atom probe tomography was used to analyze self-assembled monolayers of thiophene on different surfaces, including tungsten, platinum, and aluminum, where the tungsten was examined in both pristine and oxidized forms. A glovebag with controlled atmospheres was used to alter the level of oxidation for tungsten. It was shown that different substrates lead to substantial changes in the way thiophene adsorbs on the surface. Read More

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http://pubs.acs.org/doi/10.1021/acs.langmuir.7b01820
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http://dx.doi.org/10.1021/acs.langmuir.7b01820DOI Listing
September 2017
4 Reads

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes.

Materials (Basel) 2017 Feb 10;10(2). Epub 2017 Feb 10.

Biomaterials and Tissue Engineering Research Unit, School of AMME, University of Sydney, Sydney 2006, Australia.

Doped calcium silicate ceramics (DCSCs) have recently gained immense interest as a new class of candidates for the treatment of bone defects. Although calcium phosphates and bioactive glasses have remained the mainstream of ceramic bone substitutes, their clinical use is limited by suboptimal mechanical properties. DCSCs are a class of calcium silicate ceramics which are developed through the ionic substitution of calcium ions, the incorporation of metal oxides into the base binary CaO-SiO₂ system, or a combination of both. Read More

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http://dx.doi.org/10.3390/ma10020153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459133PMC
February 2017
3 Reads

Variability in static alignment and kinematics for kinematically aligned TKA.

Knee 2017 Aug 30;24(4):733-744. Epub 2017 May 30.

Department of Biomedical Engineering, University of California, Davis, Sacramento, CA 95817, USA.

Background: Total knee arthroplasty (TKA) significantly improves pain and restores a considerable degree of function. However, improvements are needed to increase patient satisfaction and restore kinematics to allow more physically demanding activities that active patients consider important. The aim of our study was to compare the alignment and motion of kinematically and mechanically aligned TKAs. Read More

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http://dx.doi.org/10.1016/j.knee.2017.04.002DOI Listing
August 2017
8 Reads

Open-field mouse brain PET: design optimisation and detector characterisation.

Phys Med Biol 2017 Jul 13;62(15):6207-6225. Epub 2017 Jul 13.

Department of Biomedical Engineering, University of California, Davis CA 95616, United States of America. Faculty of Health Sciences and Brain & Mind Centre, University of Sydney, Sydney, Australia. Faculty of Engineering, School of AMME, University of Sydney, Sydney, Australia.

'Open-field' PET, in which an animal is free to move within an enclosed space during imaging, is a very promising advance for neuroscientific research. It provides a key advantage over conventional imaging under anesthesia by enabling functional changes in the brain to be correlated with an animal's behavioural response to environmental or pharmacologic stimuli. Previously we have demonstrated the feasibility of open-field imaging of rats using motion compensation techniques applied to a commercially available PET scanner. Read More

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http://dx.doi.org/10.1088/1361-6560/aa7171DOI Listing
July 2017
27 Reads

Strontium-doped calcium silicate bioceramic with enhanced in vitro osteogenic properties.

Biomed Mater 2017 Jun 5;12(3):035003. Epub 2017 Jun 5.

Biomaterials and Tissue Engineering Research Unit, School of AMME, The University of Sydney, NSW, Australia.

Gehlenite (GLN, CaSiAlO) is a bioceramic that has been recently shown to possess excellent mechanical strength and in vitro osteogenic properties for bone regeneration. Substitutional incorporation of strontium in place of calcium is an effective way to further enhance biological properties of calcium-based bioceramics and glasses. However, such strategy has the potential to affect other important physicochemical parameters such as strength and degradation due to differences in the ionic radius of strontium and calcium. Read More

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http://dx.doi.org/10.1088/1748-605X/aa6987DOI Listing
June 2017
3 Reads

Priming Adipose Stem Cells with Tumor Necrosis Factor-Alpha Preconditioning Potentiates Their Exosome Efficacy for Bone Regeneration.

Tissue Eng Part A 2017 11 23;23(21-22):1212-1220. Epub 2017 Mar 23.

Biomaterials and Tissue Engineering Research Unit, School of AMME, The University of Sydney , Sydney, Australia .

Mesenchymal stem cells (MSCs) have been widely used for tissue repair and regeneration. However, the inherent drawbacks, including limited cell survival after cell transplantation, have hindered direct MSC transplantation for tissue repair and regeneration. The aim of this study was to investigate if exosomes isolated from MSCs can promote the proliferation and differentiation of human primary osteoblastic cells (HOBs) and be potentially used for bone tissue regeneration. Read More

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http://dx.doi.org/10.1089/ten.tea.2016.0548DOI Listing
November 2017
11 Reads

Single-stage osseointegrated reconstruction and rehabilitation of lower limb amputees: the Osseointegration Group of Australia Accelerated Protocol-2 (OGAAP-2) for a prospective cohort study.

BMJ Open 2017 03 22;7(3):e013508. Epub 2017 Mar 22.

Biomaterials and Tissue Engineering Research Unit, School of AMME, University of Sydney, Sydney, New South Wales, Australia.

Introduction: Lower limb amputations have detrimental influences on the quality of life, function and body image of the affected patients. Following amputation, prolonged rehabilitation is required for patients to be fitted with traditional socket prostheses, and many patients experience symptomatic socket-residuum interface problems which lead to reduced prosthetic use and quality of life. Osseointegration has recently emerged as a novel approach for the reconstruction of amputated limbs, which overcomes many of the socket-related problems by directly attaching the prosthesis to the skeletal residuum. Read More

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http://dx.doi.org/10.1136/bmjopen-2016-013508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372148PMC
March 2017
4 Reads

Bone Microenvironment, Stem Cells, and Bone Tissue Regeneration.

Stem Cells Int 2017 17;2017:1315243. Epub 2017 Jan 17.

Department of Orthopaedics, The First Affiliated Hospital, Orthopaedic Institute, Soochow University, 188 Shizi St., Suzhou, Jiangsu 215006, China.

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http://dx.doi.org/10.1155/2017/1315243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282439PMC
January 2017
5 Reads

Effects of Sr-HT-Gahnite on osteogenesis and angiogenesis by adipose derived stem cells for critical-sized calvarial defect repair.

Sci Rep 2017 01 20;7:41135. Epub 2017 Jan 20.

Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.

Tissue engineering strategies to construct vascularized bone grafts are now attracting much attention. Strontium-hardystonite-Gahnite (Sr-HT-Gahnite) is a strong, highly porous, and biocompatible calcium silicate based bio-ceramic that contains strontium and zinc ions. Adipose derived stem cells (ASCs) have been demonstrated to have the ability in promoting osteogenesis and angiogenesis. Read More

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http://dx.doi.org/10.1038/srep41135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247715PMC
January 2017
11 Reads

X-linked elliptocytosis with impaired growth is related to mutated AMMECR1.

Gene 2017 Mar 9;606:47-52. Epub 2017 Jan 9.

Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

In this study, we report a family with X-linked recessive syndrome caused by mutated AMMECR1 and characterized by elliptocytosis with or without anemia, midface hypoplasia, proportionate short stature and hearing loss. Recently, mutations in AMMECR1 were reported in two maternal half-brothers, presenting with nephrocalcinosis, midface hypoplasia and, in one of the siblings, deafness and elliptocytosis. AMMECR1 gene is localized in the critical region of contiguous deletion syndrome on Xq22. Read More

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http://dx.doi.org/10.1016/j.gene.2017.01.001DOI Listing
March 2017
19 Reads

Osseointegrated Prosthetic Limb for the treatment of lower limb amputations : Experience and outcomes.

Unfallchirurg 2017 Apr;120(4):306-311

Biomaterials and Tissue Engineering Research Unit, School of AMME, University of Sydney, 2006, Sydney, NSW, Australia.

Background: Osseointegration has emerged over the past two decades as a dramatically different approach for the treatment of lower limb amputations, which involves direct attachment of the prosthesis to the skeletal residuum. This approach can address many of the socket-interface issues associated with socket prostheses which represent the current standard of care for amputees. The Osseointegrated Prosthetic Limb (OPL) is an osseointegration implant with a new design and improved features compared to other available implant systems. Read More

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http://link.springer.com/10.1007/s00113-016-0296-8
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http://dx.doi.org/10.1007/s00113-016-0296-8DOI Listing
April 2017
18 Reads

A reformative shear precipitation procedure for the fabrication of vancomycin-loaded poly(lactide-co-glycolide) microspheres.

J Biomater Appl 2017 02 9;31(7):995-1009. Epub 2017 Jan 9.

1 Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.

This study reports the encapsulation of vancomycin, as a model hydrophilic drug, into poly(lactide-co-glycolide) microspheres using a novel reformative shear precipitation procedure. In contrast to the external aqueous phase used in the conventional microencapsulation technique based on emulsion solvent evaporation/extraction, the reformative shear precipitation procedure explored in this study uses a shear medium composed of glycerol as the viscous medium and ethanol as polymer antisolvent, which is relatively immiscible with the hydrophilic drug. This limits drug diffusion and leads to rapid microsphere solidification, which allows a large proportion of the hydrophilic drug to be encapsulated within the microspheres. Read More

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http://dx.doi.org/10.1177/0885328216689199DOI Listing
February 2017
15 Reads

Image Based Mango Fruit Detection, Localisation and Yield Estimation Using Multiple View Geometry.

Sensors (Basel) 2016 Nov 15;16(11). Epub 2016 Nov 15.

The Australian Centre for Field Robotics (ACFR), Department of Aerospace, Mechanical and Mechatronic Engineering (AMME),The University of Sydney, Sydney, NSW 2006, Australia.

This paper presents a novel multi-sensor framework to efficiently identify, track, localise and map every piece of fruit in a commercial mango orchard. A multiple viewpoint approach is used to solve the problem of occlusion, thus avoiding the need for labour-intensive field calibration to estimate actual yield. Fruit are detected in images using a state-of-the-art faster R-CNN detector, and pair-wise correspondences are established between images using trajectory data provided by a navigation system. Read More

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http://www.mdpi.com/1424-8220/16/11/1915
Publisher Site
http://dx.doi.org/10.3390/s16111915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134574PMC
November 2016
6 Reads

: a single point mutation causes developmental delay, midface hypoplasia and elliptocytosis.

J Med Genet 2017 04 3;54(4):269-277. Epub 2016 Nov 3.

Human Genetics & Genomic Medicine, University of Southampton, Duthie Building (Mailpoint 808), Southampton General Hospital, Southampton, UK.

Background: Deletions in the Xq22.3-Xq23 region, inclusive of , have been associated with a contiguous gene deletion syndrome characterised by lport syndrome with intellectual disability (ental retardation), idface hypoplasia and lliptocytosis (AMME). The extrarenal biological and clinical significance of neighbouring genes to the Alport locus has been largely speculative. Read More

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http://dx.doi.org/10.1136/jmedgenet-2016-104100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502304PMC
April 2017
17 Reads
1 Citation
6.340 Impact Factor

KCNE4 and KCNE5: K(+) channel regulation and cardiac arrhythmogenesis.

Gene 2016 Nov 30;593(2):249-60. Epub 2016 Jul 30.

Bioelectricity Laboratory, Dept. of Pharmacology and Dept. of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA. Electronic address:

KCNE proteins are single transmembrane-segment voltage-gated potassium (Kv) channel ancillary subunits that exhibit a diverse range of physiological functions. Human KCNE gene mutations are associated with various pathophysiological states, most notably cardiac arrhythmias. Of the five isoforms in the human KCNE gene family, KCNE4 and the X-linked KCNE5 are, to date, the least-studied. Read More

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http://dx.doi.org/10.1016/j.gene.2016.07.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166581PMC
November 2016
4 Reads

Molecular Relaxations in Supercooled Liquid and Glassy States of Amorphous Quinidine: Dielectric Spectroscopy and Density Functional Theory Approaches.

J Phys Chem B 2016 08 27;120(30):7579-92. Epub 2016 Jul 27.

Normandie Univ, Laboratoire SMS - EA3233, Univ Rouen , F-76821 Mont Saint Aignan, France.

In this article, we conduct a comprehensive molecular relaxation study of amorphous Quinidine above and below the glass-transition temperature (Tg) through broadband dielectric relaxation spectroscopy (BDS) experiments and theoretical density functional theory (DFT) calculations, as one major issue with the amorphous state of pharmaceuticals is life expectancy. These techniques enabled us to determine what kind of molecular motions are responsible, or not, for the devitrification of Quinidine. Parameters describing the complex molecular dynamics of amorphous Quinidine, such as Tg, the width of the α relaxation (βKWW), the temperature dependence of α-relaxation times (τα), the fragility index (m), and the apparent activation energy of secondary γ relaxation (Ea-γ), were characterized. Read More

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http://dx.doi.org/10.1021/acs.jpcb.6b04242DOI Listing
August 2016
8 Reads
1 Citation

A bioceramic with enhanced osteogenic properties to regulate the function of osteoblastic and osteocalastic cells for bone tissue regeneration.

Biomed Mater 2016 06 15;11(3):035018. Epub 2016 Jun 15.

Biomaterials and Tissue Engineering Research Unit, School of AMME, The University of Sydney, Sydney 2006, Australia.

Bioceramics for regenerative medicine applications should have the ability to promote adhesion, proliferation and differentiation of osteoblast and osteoclast cells. Osteogenic properties of the material are essential for rapid bone regeneration and new bone formation. The aim of this study was to develop a silicate-based ceramic, gehlenite (GLN, Ca2Al2SiO7), and characterise its physiochemical, biocompatibility and osteogenic properties. Read More

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http://dx.doi.org/10.1088/1748-6041/11/3/035018DOI Listing
June 2016
3 Reads

Novel bone substitute composed of chitosan and strontium-doped α-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility.

Mater Sci Eng C Mater Biol Appl 2016 Sep 20;66:84-91. Epub 2016 Apr 20.

Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China. Electronic address:

Calcium sulfate is in routine clinical use as a bone substitute, offering the benefits of biodegradability, biocompatibility and a long history of use in bone repair. The osteoconductive properties of calcium sulfate may be further improved by doping with strontium ions. Nevertheless, the high degradation rate of calcium sulfate may impede bone healing as substantial material degradation may occur before the healing process is complete. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931163037
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http://dx.doi.org/10.1016/j.msec.2016.04.070DOI Listing
September 2016
17 Reads

Biomechanical optimization of subject-specific implant positioning for femoral head resurfacing to reduce fracture risk.

Proc Inst Mech Eng H 2016 Jul 19;230(7):668-74. Epub 2016 Apr 19.

Biomedical Engineering, School of Aerospace, Mechanical and Mechatronic Engineering (AMME), University of Sydney, Sydney, NSW, Australia.

Peri-prosthetic femoral neck fracture after femoral head resurfacing can be either patient-related or surgical technique-related. The study aimed to develop a patient-specific finite element modelling technique that can reliably predict an optimal implant position and give minimal strain in the peri-prosthetic bone tissue, thereby reducing the risk of peri-prosthetic femoral neck fracture. The subject-specific finite element modelling was integrated with optimization techniques including design of experiments to best possibly position the implant for achieving minimal strain for femoral head resurfacing. Read More

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http://dx.doi.org/10.1177/0954411916644633DOI Listing

Fabrication of Semiordered Nanopatterned Diamond-like Carbon and Titania Films for Blood Contacting Applications.

ACS Appl Mater Interfaces 2016 Mar 8;8(11):6802-10. Epub 2016 Mar 8.

Graduate School of Biomedical Engineering, University of New South Wales , Sydney, New South Wales 2052, Australia.

Biomaterials with the ability to interface with, but not activate, blood components are essential for a multitude of medical devices. Diamond-like carbon (DLC) and titania (TiO2) have shown promise for these applications; however, both support platelet adhesion and activation. This study explored the fabrication of nanostructured DLC and TiO2 thin film coatings using a block copolymer deposition technique that produced semiordered nanopatterns with low surface roughness (5-8 nm Rrms). Read More

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http://dx.doi.org/10.1021/acsami.5b11614DOI Listing
March 2016
9 Reads

Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiae.

Biomed Mater 2016 Feb 19;11(1):015016. Epub 2016 Feb 19.

Biomaterials and Tissue Engineering Research Unit, School of AMME, University of Sydney, Sydney, NSW 2006, Australia. These authors contributed equally.

The treatment of large bone defects, particularly those with segmental bone loss, remains a significant clinical challenge as current approaches involving surgery or bone grafting often do not yield satisfactory long-term outcomes. This study reports the evaluation of novel ceramic scaffolds applied as bone graft substitutes in a clinically relevant in vivo model. Baghdadite scaffolds, unmodified or modified with a polycaprolactone coating containing bioactive glass nanoparticles, were implanted into critical-sized segmental bone defects in sheep tibiae for 26 weeks. Read More

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http://dx.doi.org/10.1088/1748-6041/11/1/015016DOI Listing
February 2016
5 Reads

Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol.

Int J Pharm 2016 Feb 17;499(1-2):67-73. Epub 2015 Dec 17.

Normandie Univ, Laboratoire SMS-EA3233, Univ Rouen, F-76821 Mont Saint Aignan, France. Electronic address:

This study investigates for the first time the thermodynamic changes of Biclotymol upon high-energy milling at various levels of temperature above and below its glass transition temperature (Tg). Investigations have been carried out by temperature modulated differential scanning calorimetry (TM-DSC) and X-ray powder diffraction (XRPD). Results indicate that Biclotymol undergoes a solid-state amorphization upon milling at Tg-45 °C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173153043
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http://dx.doi.org/10.1016/j.ijpharm.2015.12.032DOI Listing
February 2016
6 Reads
3.650 Impact Factor

A plasma-sprayed titanium proximal coating reduces the risk of periprosthetic femoral fracture in cementless hip arthroplasty.

Biomed Mater Eng 2015 ;25(3):267-78

Biomedical Engineering, AMME, University of Sydney, Sydney, NSW, Australia.

Background: The design of femoral component used in total hip arthroplasty is known to influence the incidence of periprosthetic femoral fractures (PFFs) in cementless hip arthroplasty.

Objective: This study was undertaken to determine if 2 potential changes to an existing ABG II-standard cementless implant - addition of a roughened titanium plasma-sprayed proximal coating (ABG II-plasma) and lack of medial scales (ABG II-NMS) could decrease the risk of PFF in the intraoperative and early postoperative periods.

Methods: Six pairs of human cadaveric femurs were harvested and divided into 2 groups, each receiving either of the altered implants and ABG II-standard (control). Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/BME-151279DOI Listing
July 2016
6 Reads

Characterization of novel carcinoma cell lines for the analysis of therapeutical strategies fighting pancreatic cancer.

Cell Biosci 2015 28;5:51. Epub 2015 Aug 28.

Institute for Experimental Surgery, Rostock University Medical Center, University of Rostock, Schillingallee 69a, 18057 Rostock, Germany.

Background: Preclinical evaluations of chemotherapies depend on clinically relevant animal models for pancreatic cancer. The injection of syngeneic murine adenocarcinoma cells is one efficient option to generate carcinomas in mice with an intact immune system. However, this option is constrained by the paucity of appropriate cell lines. Read More

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http://dx.doi.org/10.1186/s13578-015-0038-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551666PMC
August 2015
41 Reads

Processing and Properties of Zirconia-Toughened Alumina Prepared by Gelcasting.

Materials (Basel) 2015 Jul 16;8(7):4344-4362. Epub 2015 Jul 16.

Biomedical Engineering, School of AMME J07, University of Sydney, Sydney 2006, Australia.

Zirconia-toughened alumina (ZTA) using yttria-stabilised zirconia is a good option for ceramic-ceramic bearing couples for hip joint replacement. Gelcasting is a colloidal processing technique capable of producing complex products with a range of dimensions and materials by a relatively low-cost production process. Using gelcasting, ZTA samples were prepared, optimising the stages of fabrication, including slurry preparation with varying solid loadings, moulding and de-moulding, drying and sintering. Read More

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http://dx.doi.org/10.3390/ma8074344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455639PMC

A biphasic scaffold based on silk and bioactive ceramic with stratified properties for osteochondral tissue regeneration.

J Mater Chem B 2015 Jul;3(26):5361-5376

Biomaterials and Tissue Engineering Research Unit, School of AMME, University of Sydney, Sydney, NSW 2006, Australia.

Significant clinical challenges encountered in the effective long-term treatment of osteochondral defects have inspired advancements in scaffold-based tissue engineering techniques to aid repair and regeneration. This study reports the development of a biphasic scaffold produced via a rational combination of silk fibroin and bioactive ceramic with stratified properties to satisfy the complex and diverse regenerative requirements of osteochondral tissue. Structural examination showed that the biphasic scaffold contained two phases with different pore morphologies to match the cartilage and bone segments of osteochondral tissue, which were joined at a continuous interface. Read More

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http://dx.doi.org/10.1039/C5TB00353ADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494762PMC
July 2015
8 Reads

Crystallization kinetics and molecular mobility of an amorphous active pharmaceutical ingredient: A case study with Biclotymol.

Int J Pharm 2015 Jul 21;490(1-2):248-57. Epub 2015 May 21.

Crystal Genesis Unit, EA 3233 SMS, Normandie Université, Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France.

The present case study focuses on the crystallization kinetics and molecular mobility of an amorphous mouth and throat drug namely Biclotymol, through differential scanning calorimetry (DSC), temperature resolved X-ray powder diffraction (TR-XRPD) and hot stage microscopy (HSM). Kinetics of crystallization above the glass transition through isothermal and non-isothermal cold crystallization were considered. Avrami model was used for isothermal crystallization process. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173150045
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http://dx.doi.org/10.1016/j.ijpharm.2015.05.036DOI Listing
July 2015
8 Reads
3.650 Impact Factor

Cumulative therapeutic effects of phytochemicals in Arnica montana flower extract alleviated collagen-induced arthritis: inhibition of both pro-inflammatory mediators and oxidative stress.

J Sci Food Agric 2016 Mar 29;96(5):1500-10. Epub 2015 May 29.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India.

Background: The plant Arnica montana is used in folk medicine to alleviate pain, inflammation and swelling of muscles and joints associated with rheumatoid arthritis and other inflammatory conditions. The present study aimed to investigate the therapeutic effects and mechanism of action of A. montana flower methanol extract (AMME) against both inflammation and oxidative stress in a collagen-induced arthritis (CIA) rat model. Read More

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http://dx.doi.org/10.1002/jsfa.7252DOI Listing
March 2016
23 Reads

Subject specific finite element modeling of periprosthetic femoral fracture using element deactivation to simulate bone failure.

Med Eng Phys 2015 Jun 27;37(6):567-73. Epub 2015 Apr 27.

Biomedical Engineering, AMME, University of Sydney, Sydney, NSW 2006, Australia.

Subject-specific finite element (FE) modeling methodology could predict peri-prosthetic femoral fracture (PFF) for cementless hip arthoplasty in the early postoperative period. This study develops methodology for subject-specific finite element modeling by using the element deactivation technique to simulate bone failure and validate with experimental testing, thereby predicting peri-prosthetic femoral fracture in the early postoperative period. Material assignments for biphasic and triphasic models were undertaken. Read More

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http://dx.doi.org/10.1016/j.medengphy.2015.03.012DOI Listing
June 2015
2 Reads

Subject-specific finite element model with an optical tracking system in total hip replacement surgery.

Proc Inst Mech Eng H 2015 Apr;229(4):280-90

Biomedical Engineering, AMME, The University of Sydney, Sydney, NSW, Australia.

Intra-operative peri-prosthetic femoral fractures are a significant concern in total hip arthroplasty and can occur at any time during surgery, with the highest incidence during implant insertion. This study combines subject-specific finite element analysis modeling with an optical tracking system to characterize the resultant strain in the bone and results of impaction during total hip replacement surgery. The use of ABG II femoral stem (Stryker Orthopaedics, Mahwah, NJ, USA) in the model yielded the following results. Read More

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http://dx.doi.org/10.1177/0954411915578688DOI Listing
April 2015
1 Read

Impact of diabetes type II and chronic inflammation on pancreatic cancer.

BMC Cancer 2015 Feb 13;15:51. Epub 2015 Feb 13.

Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee 69a, 18057, Rostock, Germany.

Background: We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth.

Methods: Pancreatic carcinomas were assessed in a syngeneic orthotopic pancreas adenocarcinoma model after injection of 6606PDA cells in the pancreas head of either B6.V-Lep(ob/ob) mice exhibiting a type II diabetes-like syndrome or normoglycemic mice. Read More

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http://dx.doi.org/10.1186/s12885-015-1047-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336675PMC
February 2015
11 Reads

Cellular Response to Doping of High Porosity Foamed Alumina with Ca, P, Mg, and Si.

Materials (Basel) 2015 Mar 13;8(3):1074-1088. Epub 2015 Mar 13.

Biomedical Engineering, School of AMME J07, University of Sydney, Sydney, NSW 2006, Australia.

Foamed alumina was previously synthesised by direct foaming of sulphate salt blends varying ammonium mole fraction (AMF), foaming heating rate and sintering temperature. The optimal product was produced with 0.33AMF, foaming at 100 °C/h and sintering at 1600 °C. Read More

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http://dx.doi.org/10.3390/ma8031074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455451PMC

Zirconium ions up-regulate the BMP/SMAD signaling pathway and promote the proliferation and differentiation of human osteoblasts.

PLoS One 2015 20;10(1):e0113426. Epub 2015 Jan 20.

Biomaterials and Tissue Engineering Research Unit, School of AMME, The University of Sydney, Sydney, New South Wales 2006, Australia.

Zirconium (Zr) is an element commonly used in dental and orthopedic implants either as zirconia (ZrO2) or in metal alloys. It can also be incorporated into calcium silicate-based ceramics. However, the effects of in vitro culture of human osteoblasts (HOBs) with soluble ionic forms of Zr have not been determined. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113426PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300214PMC
September 2015
4 Reads

Micro-poro-elasticity of baghdadite-based bone tissue engineering scaffolds: a unifying approach based on ultrasonics, nanoindentation, and homogenization theory.

Mater Sci Eng C Mater Biol Appl 2015 Jan 28;46:553-64. Epub 2014 Oct 28.

Institute for Mechanics of Materials and Structures, Vienna University of Technology (TU Wien), Karlsplatz 13/E202, A-1040 Vienna, Austria. Electronic address:

Microstructure-elasticity relations for bone tissue engineering scaffolds are key to rational biomaterial design. As a contribution thereto, we here report comprehensive length measuring, weighing, and ultrasonic tests at 0.1MHz frequency, on porous baghdadite (Ca3ZrSi2O9) scaffolds. Read More

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http://dx.doi.org/10.1016/j.msec.2014.10.072DOI Listing
January 2015
4 Reads