2,131 results match your criteria American journal of translational research[Journal]


Anatomical single bundle anterior cruciate ligament reconstruction with rounded rectangle tibial tunnel and oval femoral tunnel: a prospective comparative study versus conventional surgery.

Am J Transl Res 2019 15;11(3):1908-1918. Epub 2019 Mar 15.

Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital Beijing, People's Republic of China.

Conventional anatomical single bundle anterior cruciate ligament (ACL) reconstruction technique with round tunnels could not simulate morphology of native insertion, while studies about ACL reconstruction technique with modified tunnels based on morphology of anatomical insertion are rare. The purpose of this study was to demonstrate an ACL reconstruction technique with rounded rectangle tibial tunnel and oval femoral tunnel and compare clinical outcomes with conventional technique. A prospective comparative study was performed in 80 consecutive subjects who underwent ACL reconstruction with the conventional round tunnels (RT-Group, n=40) or modified tunnels (MT-Group, n=40). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456533PMC
March 2019
1 Read

Angiopoietin-2 induces the neuronal differentiation of mouse embryonic NSCs via phosphatidylinositol 3 kinase-Akt pathway-mediated phosphorylation of mTOR.

Am J Transl Res 2019 15;11(3):1895-1907. Epub 2019 Mar 15.

Department of Orthopedics, Tianjin Medical University General Hospital No. 154 Anshan Road, Heping District, Tianjin 300052, PR China.

The fate of neural stem cells (NSCs) is decided by numerous growth factors. Among these factors, the well-known angiogenic factor angiopoietin-2 (Ang-2) has been revealed to participate in neurogenesis separate from its role in angiogenesis. However, the effect of Ang-2 on the fate determination of mouse embryonic NSCs and the underlying mechanism remain unclear. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456538PMC
March 2019
3 Reads
3.226 Impact Factor

Astaxanthin prevents against lipopolysaccharide-induced acute lung injury and sepsis via inhibiting activation of MAPK/NF-κB.

Am J Transl Res 2019 15;11(3):1884-1894. Epub 2019 Mar 15.

Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, P. R. China.

Background: Endotoxin-induced acute inflammatory diseases such as sepsis, mediated by excessive production of various pro-inflammatory cytokines remain the leading cause of mortality in critically ill patients. Lipopolysaccharide (LPS), the characteristic endotoxin found in the outer membrane of Gram-negative bacteria, can induce the innate immunity system and through Mitogen activated protein kinase (MAPK) and Nuclear Factor-κB (NF-κB), increase the production of inflammatory mediators. Astaxanthin (ASX), a xanthophyll carotenoid, exerts beneficial effects against oxidation, inflammation, and cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456544PMC
March 2019
1 Read

Expression of IL-17 with tumor budding as a prognostic marker in oral squamous cell carcinoma.

Am J Transl Res 2019 15;11(3):1876-1883. Epub 2019 Mar 15.

Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine Shanghai, China.

We evaluated the relationship between IL-17 expression and tumor budding in the oral squamous cell carcinoma (OSCC) tumor invasion front (TIF). We also analyzed the correlation between OSCC prognosis and the co-expression of IL-17 and tumor budding. We obtained tumor tissues, tumor margins, and adjacent normal tissues from a total of 80 patients with OSCC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456524PMC

Treatment selection of recurrent hepatocellular carcinoma with microvascular invasion at the initial hepatectomy.

Am J Transl Res 2019 15;11(3):1864-1875. Epub 2019 Mar 15.

Department of Medical Imaging, Sun Yat-sen University Cancer Center 651 Dongfeng Road East, Guangzhou, China.

Background: Recurrent hepatocellular carcinoma (rHCC) patients with microvascular invasive (MVI) positive at first resection usually had poorly differentiated tumors and worse survivals. The optimal treatment for this population remains to be elucidated.

Methods: We retrospectively analyzed 319 rHCC patients with MVI-positive at first resection from June, 2009 to June, 2017. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456518PMC
March 2019
1 Read

Impact of serum omentin-1 levels on functional prognosis in nondiabetic patients with ischemic stroke.

Am J Transl Res 2019 15;11(3):1854-1863. Epub 2019 Mar 15.

Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University Xuzhou 221116, P. R. China.

Objective: Omentin-1, an adipokine released from visceral fat tissue, is associated with diabetes and stroke. The purpose of this study was to assess the impact of serum omentin-1 levels on functional prognosis in nondiabetic patients with ischemic stroke.

Methods: From March 2016 to December 2017, consecutive patients with first-ever ischemic stroke admitted to our hospital, China, were recorded. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456553PMC
March 2019
1 Read

miR-125a-3p decreases levels of interlukin-17 and suppresses renal fibrosis via down-regulating TGF-β1 in systemic lupus erythematosus mediated Lupus nephritic mice.

Am J Transl Res 2019 15;11(3):1843-1853. Epub 2019 Mar 15.

Department of Nephrology, Hanzhong Central Hospital Hanzhong 723000, Shaanxi, China.

Lupus nephritis (LN) is an autoimmune disorder mediated by systemic lupus erythematosus (SLE). Micro RNAs also called as miRs act potentially in the development and progression of SLE. MiR-125a-3p is reported to be down-regulated inpatients of SLE. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456516PMC
March 2019
1 Read

Long noncoding RNA LINC00341 promotes the vascular smooth muscle cells proliferation and migration via miR-214/FOXO4 feedback loop.

Am J Transl Res 2019 15;11(3):1835-1842. Epub 2019 Mar 15.

Department of Cardiology, Affiliated Hospital of Binzhou Medical University Binzhou, Shandong, China.

Increasing evidences have indicated the vital roles of long noncoding RNA (lncRNA) in the atherosclerosis. However, whether lncRNA LINC00341 play pivotal roles in the vascular smooth muscle cells (VSMCs) is still unclear. This work presents the authentic functions of LINC00341 on the proliferation and migration of VSMCs and unveils the underlying mechanism. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456561PMC

Long noncoding RNA OIP5-AS1 accelerates the ox-LDL mediated vascular endothelial cells apoptosis through targeting GSK-3β via recruiting EZH2.

Am J Transl Res 2019 15;11(3):1827-1834. Epub 2019 Mar 15.

Department of Cardiology, Tianjin First Center Hospital Tianjin 300192, China.

An increasing amount of research is demonstrating the role of long noncoding RNAs (lncRNAs) in human cardiovascular disease, and in particular, atherosclerosis. To date, the mechanism through which lncRNA OIP5-AS1 regulates the oxidative low-density lipoprotein (ox-LDL)-mediated endothelial cell apoptosis is still unclear. Results from this study found that lncRNA OIP5-AS1 was significantly over-expressed in the human umbilical vein endothelial cells (HUVECs) administered with ox-LDL. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456540PMC

Loss of Wnt4 expression inhibits the odontogenic potential of dental pulp stem cells through JNK signaling in pulpitis.

Am J Transl Res 2019 15;11(3):1819-1826. Epub 2019 Mar 15.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi'an Jiaotong University Xi'an, Shaanxi, China.

Dental pulp stem cell (DPSC)-based odontogenic regeneration in inflammatory conditions is important in the process of pulpitis. DPSCs have been reported to lose potential for odontogenic regeneration in inflammatory conditions. This study aims to determine the mechanism of impaired odontogenic differentiation of DPSCs in an inflammatory microenvironment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456534PMC

Increased sFRP3 expression correlated to senescence of endothelial cells in the aging process of mice.

Am J Transl Res 2019 15;11(3):1810-1818. Epub 2019 Mar 15.

The Centre for Transplantation and Renal Research, Westmead Institute for Medical Research, University of Sydney NSW, Australia.

Aging is tightly associated with various diseases, such as cardiovascular diseases; however, there is no effective biomarker to detect and evaluate the aging process . Therefore, it is critical to identify new aging biomarkers for earlier diagnose of aging-related diseases. This study investigated the profile of cytokines in serum samples of young and aged mice with the purpose of exploring new biomarkers that have remarkable alterations in aging. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456558PMC
March 2019
1 Read

RasGRP3 in peripheral blood mononuclear cells is associated with disease activity and implicated in the development of systemic lupus erythematosus.

Am J Transl Res 2019 15;11(3):1800-1809. Epub 2019 Mar 15.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.

This study examined the relationship between the expression of Ras guanyl nucleotide-releasing protein 3 (RasGRP3) and disease activity in systemic lupus erythematosus (SLE) and explored the possible mechanisms in mice. We detected the expression of RasGRP3 in peripheral blood mononuclear cells (PBMCs) of SLE patients (n=26) and healthy controls (n=20) by employing RT-PCR and studied the association between the mRNA expression of RasGRP3 in PBMCs and the clinical findings. We also measured the protein level of RasGRP3 in PBMCs by Western blotting (n=10). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456560PMC
March 2019
1 Read

Smooth muscle atrophy and colon pathology in SMN deficient mice.

Am J Transl Res 2019 15;11(3):1789-1799. Epub 2019 Mar 15.

Department of Physiology, University of Pennsylvania Perelman School of Medicine Philadelphia, PA.

Spinal muscular atrophy (SMA) is an autosomal recessive genetic disorder characterized by loss of motor neurons in the ventral horn of the spinal cord. Clinical features such as progressively lethal respiratory weakness and associated muscle wasting have been extensively studied but less attention has been given to gastrointestinal (GI) dysfunction, which is common symptomatology in SMA patients with 43% constipation, 15% abdominal pain, and 14% meteorism. In the current study, the PrP92-SMN mouse model of SMA was utilized, to complement previous studies in which cells of the Enteric Nervous system (ENS) were susceptible to Smn (survival motor neuron) deficiency and could possibly be the basis of the observed GI symptoms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456546PMC
March 2019
3 Reads

miR-9 stimulation enhances the differentiation of neural stem cells with zoanthamine by regulating Notch signaling.

Am J Transl Res 2019 15;11(3):1780-1788. Epub 2019 Mar 15.

Department of Hepatology, The First Affiliated Hospital of Kunming Medical University Kunming 650032, China.

The protective effect of zoanthamine on Alzheimer's disease by enhancing differentiation of neural stem cells (NSCs) was evaluated. NSCs were isolated from C57BL/6 mice and assessed by cell viability and apoptosis assays. The cells were separated into five different groups: green fluorescent protein (GFP; transfected with GFP), amyloid precursor protein (APP; transfected with APP), APP + zoanthamine, APP + miR-9 inhibitor, and APP + miR-9 inhibitor + zoanthamine. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456551PMC

Identification of mesothelial cells in intraoperative blood salvage.

Am J Transl Res 2019 15;11(3):1771-1779. Epub 2019 Mar 15.

Health Science - Interdipartimental Service Center, University "Magna Graecia" of Catanzaro Medical School Italy.

Intraoperative auto-transfusion with the use of cell saver systems is routinely used to reduce the rate of packed red blood transfusion in major surgery. Nevertheless some concerns have been raised on possible risks of coagulation disorders. The aim of the study was to analyze the blood processed by the cell saver, ready to be re-infused to the patient, in order to individuate unexpected cellular components, that can favor coagulopathy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456513PMC
March 2019
2 Reads

Low metallothionein 1M (MT1M) is associated with thyroid cancer cell lines progression.

Am J Transl Res 2019 15;11(3):1760-1770. Epub 2019 Mar 15.

The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou, Zhejiang, People's Republic of China.

Papillary thyroid cancer (PTC) is the most common malignancy of the thyroid carcinoma, despite ongoing advances, novel biomarkers are required for prognosis and diagnosis of PTC. Our previous research found that metallothionein 1M (MT1M) was a novel potential PTC associated gene in thyroid cancer. In the present study, the expression status and prognostic value of MT1M expression were investigated in thyroid cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456523PMC
March 2019
5 Reads

Single nucleotide polymorphisms of let-7-related genes increase susceptibility to breast cancer.

Am J Transl Res 2019 15;11(3):1748-1759. Epub 2019 Mar 15.

Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200127, China.

Background: Let-7 is a microRNA (miRNA) that targets the β2 adrenergic receptor (), hypoxia inducible factor 1 subunit alpha inhibitor (), and claudin 12 () genes. Single nucleotide polymorphisms (SNPs) in the structural or regulatory regions of these miRNA let-7-related genes may be associated with breast cancer carcinogenesis and prognosis. Low let-7 expression may increase breast cancer risk. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456510PMC

Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis.

Am J Transl Res 2019 15;11(3):1736-1747. Epub 2019 Mar 15.

Center for Craniofacial Regeneration, Columbia University Medical Center New York, NY 10032, USA.

Temporomandibular joint (TMJ) arthritis causes severe debilitation and has few treatment options. Here, we found a small molecule, DNA methyltransferase 3B (Dnmt3b), as a putative therapeutic target, partially rescued osteoarthritic phenotype. Dnmt3b was detected differentially expressed in cell zones of mandibular condylar cartilage and the expression of Dnmt3b decreased in the progression of TMJ osteoarthritis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456519PMC
March 2019
1 Read
3.226 Impact Factor

A study of the pathogenicity of variants in familial heart disease. The value of cosegregation.

Am J Transl Res 2019 15;11(3):1724-1735. Epub 2019 Mar 15.

Inherited Cardiac Disease Unit, Department of Cardiology, University Hospital Virgen de la Arrixaca Murcia, Spain.

With the development of deep sequencing, a significant proportion of mutations already listed in studies have inconclusive pathogenicity. We aim to establish the proportion of cases in which familial studies are possible and cosegregation analysis is informative. We also compare cosegregation analysis with in silico software and a proposed pathogenicity score. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456527PMC

Cancer cell-derived exosomes promote cell proliferation and inhibit cell apoptosis of both normal lung fibroblasts and non-small cell lung cancer cell through delivering alpha-smooth muscle actin.

Am J Transl Res 2019 15;11(3):1711-1723. Epub 2019 Mar 15.

Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University Zhenjiang, China.

This study aimed to investigate the effect of non-small cell lung cancer (NSCLC) cell-derived exosome on cell proliferation and apoptosis in normal lung fibroblast cells and NSCLC cells, and whether it regulates cell functions through delivering alpha-smooth muscle actin (ASMA). NSCLC exosomes were extracted from A549 cells, then cocultured with normal lung fibroblasts (HLF1 cells) and NSCLC cells (A549 cells). Blank ShRNA and ASMA ShRNA plasmids were transferred into HLF1 cells/A549 cells with or without NSCLC exosomes, which were divided into 4 groups accordingly: Negative control (NC) group, SH group, Exosome group and Exosome+SH group. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456520PMC

Combined antenatal and postnatal steroid effects on fetal and postnatal growth, and neurological outcomes in neonatal rats.

Am J Transl Res 2019 15;11(3):1697-1710. Epub 2019 Mar 15.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of California, Irvine Medical Center Orange, CA, USA.

Preterm infants are often exposed to both antenatal and postnatal glucocorticoids (GCs). We tested the hypothesis that combined antenatal and postnatal GCs have long-lasting adverse effects on fetal and neonatal growth, growth factors, and neurological outcomes. Pregnant rats were administered a single IM dose of betamethasone (0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456541PMC
March 2019
1 Read

Altered immune phenotypes in subjects with Fabry disease and responses to switching from agalsidase alfa to agalsidase beta.

Am J Transl Res 2019 15;11(3):1683-1696. Epub 2019 Mar 15.

Lysosomal and Rare Disorders Research and Treatment Center (LDRTC) Fairfax, VA 22030, USA.

Fabry disease (FD) is a rare X-linked genetic disorder caused by mutations in the gene encoding the lysosomal enzyme, α-galactosidase A (α-gal A). The mutations lead to lack of or faulty enzyme causing accumulation of globotriaosylceramide (Gb3) and related glycosphingolipids including globotriaosylsphingosine (lyso-Gb). Treatment options for FD include enzyme replacement therapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456521PMC

Overexpression of CBX2 in breast cancer promotes tumor progression through the PI3K/AKT signaling pathway.

Am J Transl Res 2019 15;11(3):1668-1682. Epub 2019 Mar 15.

Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.

Breast cancer is the second leading cause of cancer-related death among women worldwide. Emerging evidence suggests that chromobox homolog 2 (CBX2) is overexpressed in breast cancer and plays an essential role in tumor progression. However, its expression and functional roles in breast cancer development and progression require further exploration. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456535PMC

Alterations of COX-2, HER-2/neu and E-Cadherin protein expression in the prostatic adenocarcinoma: preliminary findings.

Am J Transl Res 2019 15;11(3):1653-1667. Epub 2019 Mar 15.

Department of Pathology, Assuit University Hospitals, Faculty of Medicine, Assuit University Egypt.

Altered expression of the pro-inflammatory enzyme cyclooxygenase (COX)-2, E-Cadherin cell-cell adhesion protein and Human epidermal growth factor receptor 2 (HER-2/neu, a proto-oncogene) are involved in the pathogenesis of several cancers including the prostatic adenocarcinoma (PRCa). However, to date the results of the previous studies in this neoplasm are controversial, and the relationships among expression of these molecules in benign prostatic hyperplasia (BPH) and PRCa are mostly unknown. We hypothesize that "there are alterations of COX-2, HER-2/neu and E-Cadherin protein expression in PRCa". Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456505PMC

Circular RNA hsa_circ_0002024 suppresses cell proliferation, migration, and invasion in bladder cancer by sponging miR-197-3p.

Am J Transl Res 2019 15;11(3):1644-1652. Epub 2019 Mar 15.

Department of Urology, The Third People's Hospital of Linyi Linyi, Shandong, P. R. China.

Circular RNA hsa_circ_0002024 has been reported to be underexpressed in bladder cancer (BC). However, the biological role of hsa_circ_0002024 in BC and its underlying molecular mechanisms remain unclear. In this study, the expression levels of hsa_circ_0002024 and miR-197-3p were examined by quantitative real-time polymerase chain reaction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456557PMC
March 2019
2 Reads
3.226 Impact Factor

Restoration of immune suppressor function of regulatory B cells collected from patients with allergic rhinitis with Chinese medical formula Yupingfeng San.

Am J Transl Res 2019 15;11(3):1635-1643. Epub 2019 Mar 15.

Research Center of Allergy and Immunology, School of Medicine, Shenzhen University Shenzhen, China.

Immune dysregulation, such as defects in immune suppressor function, plays an important role in the pathogenesis of many immune disorders including allergic rhinitis (AR). Some Chinese traditional medical formulae have an immune regulatory function. This study aims to restore the immune suppressor function in regulatory B cells (Bregs) collected from AR patients with a Chinese medical formula, Yupingfeng San (YPFS). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456564PMC
March 2019
1 Read

Ropivacaine mesylate exerts neurotoxicity via up-regulation of Fas/FasL expression in rat pheochromocytoma PC12 cells.

Am J Transl Res 2019 15;11(3):1626-1634. Epub 2019 Mar 15.

Department of Anesthesiology, The First People's Hospital of Xiangyang, Hubei University of Medicine Xiangyang 441000, Hubei Province, China.

It has been shown that local anesthetics have potential neurotoxicity, but the exact mechanism remains unclear. In this study, PC12 cells were treated with different concentrations of ropivacaine mesylate (0.1, 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456514PMC
March 2019
1 Read

Combined inhibition of FGFR and mTOR pathways is effective in suppressing ovarian cancer.

Am J Transl Res 2019 15;11(3):1616-1625. Epub 2019 Mar 15.

The Third Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, P. R. China.

The PI3K/AKT/mTOR signaling pathway is considered as a promising therapeutic target in the treatment of ovarian cancer (OC); however, inhibition of this pathway only exhibited moderate clinical efficacy when tested clinically. Combination of mTOR inhibitors with other anticancer compounds could improve the anticancer efficiency. Therefore, the concurrent inhibition of Fibroblast Growth Factor Receptor (FGFR) signaling pathway was evaluated in the present study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456542PMC
March 2019
1 Read

MicroRNA-524 inhibits the progress of glioma via the direct targeting of NCF2.

Am J Transl Res 2019 15;11(3):1605-1615. Epub 2019 Mar 15.

Department of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University Nanjing, Jiangsu Province, China.

In recent years, a large amount of research has reported that microRNA (miRNA) dysregulation is closely related to glioma progression. miR-524, a member of the miRNA family, has been confirmed to be involved in many human diseases, including glioma. However, the role and molecular mechanism of miR-524 in glioma have not been clarified. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456563PMC
March 2019
1 Read

Pirfenidone inhibits epidural scar fibroblast proliferation and differentiation by regulating TGF-β1-induced Smad-dependent and -independent pathways.

Am J Transl Res 2019 15;11(3):1593-1604. Epub 2019 Mar 15.

Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road, Nanjing 210029, Jiangsu, China.

Epidural fibrosis causes serious complications in patients who have undergone laminectomy. Pirfenidone is an effective antifibrotic agent but its effect on epidural fibrosis remains unclear. In this study, we aimed to investigate the effect of pirfenidone on epidural fibrosis and to evaluate its mechanism of action on human epidural scar fibroblasts. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456526PMC

CHD1L promotes cell cycle progression and cell motility by up-regulating MDM2 in breast cancer.

Am J Transl Res 2019 15;11(3):1581-1592. Epub 2019 Mar 15.

Comprehensive Breast Health Center, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University 197 Ruijin Second Road, Shanghai 200025, P. R. China.

Chromodomain helicase/ATPase DNA-binding protein 1-like (CHD1L) gene is a novel oncogene amplified in many solid tumors. We investigated its role in breast cancer. CHD1L was over-expressed in 49. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456556PMC
March 2019
3.226 Impact Factor

Alagebrium targets the miR-27b/TSP-1 signaling pathway to rescue N-carboxymethyl-lysine-induced endothelial dysfunction.

Am J Transl Res 2019 15;11(3):1569-1580. Epub 2019 Mar 15.

Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University No. 415, Fengyang Road, Huangpu District, Shanghai 200003, China.

N-carboxymethyl-lysine (CML), a major isoform of advanced glycation end products (AGEs), plays a crucial role in the functional damage of diabetes mellitus. However, it is not clear whether ALT-711 (alagebrium), an inhibitor of AGEs, is capable to rescue CML-induced poor angiogenesis, as well as the underlying mechanism. MicroRNA-27b (miR-27b) promotes angiogenesis through down-regulation of anti-angiogenic protein thrombospondin-1 (TSP-1). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456531PMC

The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery.

Am J Transl Res 2019 15;11(3):1555-1568. Epub 2019 Mar 15.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Avenue, Wuhan 430030, Hubei, China.

Postoperative cognitive dysfunction (POCD) is a neurological sequela of surgery and anesthesia. It occurs with high incidence in the aged population. Neuroinflammation is considered one of the least controversial culprits contributing to this postsurgical cognitive impairment, although it is a matter of debate as to why this complication occurs frequently in geriatric individuals. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456566PMC

Neurotropin reduces memory impairment and neuroinflammation via BDNF/NF-κB in a transgenic mouse model of Alzheimer's disease.

Am J Transl Res 2019 15;11(3):1541-1554. Epub 2019 Mar 15.

Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou 510120, Guangdong, China.

Alzheimer's disease (AD) is a devastating neurodegenerative disease with limited treatments and no cure. Neurotropin (NTP) is an analgesic drug widely prescribed for neuropathic pain. Increasing evidence suggests that NTP may also protect against neurodegeneration, but NTP's treatment potential against memory impairments of AD remains to be explored. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456545PMC
March 2019
3.226 Impact Factor

Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype.

Am J Transl Res 2019 15;11(3):1531-1540. Epub 2019 Mar 15.

Fibrosis Discovery, Bristol Myers Squibb Pennington 08534, NJ.

Nonalcoholic steatohepatitis represents a significant and rapidly growing unmet medical need. The development of novel therapies has been hindered in part, by the limitations of existing preclinical models. There is a strong need for physiologically relevant and liver fibrosis models that are characterized by better translational predictability. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456529PMC

Regulation of Krüppel-like factor 8 by the NEDD4 E3 ubiquitin ligase.

Am J Transl Res 2019 15;11(3):1521-1530. Epub 2019 Mar 15.

Burnett School of Biomedical Sciences University of Central Florida College of Medicine Orlando, FL 32827, USA.

Krüppel-like factor 8 (KLF8) plays many important roles in various diseases, especially cancer. Previous studies have shown that KLF8 is regulated by ubiquitylation. The molecular mechanism underlying this posttranslational modification of KLF8, however, has not been investigated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456509PMC
March 2019
7 Reads

Retinol palmitate protects against myocardial ischemia/reperfusion injury via reducing oxidative stress and inhibiting apoptosis.

Am J Transl Res 2019 15;11(3):1510-1520. Epub 2019 Mar 15.

Intensive Care Unit, The Second Affiliated and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, China.

The purpose of this study was to determine whether retinol palmitate could protect against myocardial ischemia/reperfusion (I/R) injury and explore the underlying mechanism. Retinol palmitate reduced the level of reactive oxygen species and prevented cellular apoptosis. , retinol palmitate increased superoxide dismutase (SOD) activity and reduced the level of malondialdehyde in I/R mice. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456537PMC

Fetuin B aggravates liver X receptor-mediated hepatic steatosis through AMPK in HepG2 cells and mice.

Am J Transl Res 2019 15;11(3):1498-1509. Epub 2019 Mar 15.

Department of Geriatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003, Zhejiang Province, China.

Previous findings supported that fetuin B, a new hepatokine, may be involved in the development of hepatic steatosis, but the mechanism is still unknown. This study aims to investigate the role of fetuin B in hepatic steatosis in C57BL/6 mice and HepG2 cells. 1) We found that the administration of recombinant fetuin B aggravated hepatic lipid accumulation caused by free fatty acids (FFAs) or high fat diet, and . Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456555PMC
March 2019
5 Reads

Hemiepiphysiodesis stapling induces ER stress apoptosis and autophagy in rat growth plates.

Am J Transl Res 2019 15;11(3):1486-1497. Epub 2019 Mar 15.

Department of General Surgery, Shanghai Tenth People's Hospital of Tong Ji University Shanghai 200072, China.

Angular deformities of adolescents can be treated with temporary hemiepiphysiodesis. It is confirmed that mechanical staples leading to apoptosis of chondrocyte in the growth plate. In addition, clinical evidences revealed that release from growth-inhibition condition resulted in catch-up growth, which caused damage to the patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456511PMC
March 2019
5 Reads

Rapamycin inhibits peritoneal fibrosis by modifying lipid homeostasis in the peritoneum.

Am J Transl Res 2019 15;11(3):1473-1485. Epub 2019 Mar 15.

Institute of Nephrology, Affiliated Drum Tower Hospital, Medical School of Nanjing University Nanjing 210008, Jiangsu Province, China.

Peritoneal fibrosis (PF) is characterized by progressive accumulation of extracellular matrix (ECM) components in the peritoneum under high glucose conditions. Rapamycin has previously been shown to inhibit ECM accumulation of peritoneal mesothelial cells (PMCs) and prevent PF. Here we explored the undefined mechanisms by which rapamycin inhibits ECM accumulation of PMCs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456554PMC
March 2019
4 Reads

Pyrroloquinoline quinone prevents knee osteoarthritis by inhibiting oxidative stress and chondrocyte senescence.

Am J Transl Res 2019 15;11(3):1460-1472. Epub 2019 Mar 15.

Department of Anatomy, Histology and Embryology, Nanjing Medical University Nanjing, Jiangsu, People's Republic of China.

Accumulating evidence suggests that oxidative stress plays an important role in the progression of osteoarthritis (OA), and pyrroloquinoline quinone (PQQ) is considered a strong antioxidant. However, it is unclear whether PQQ can prevent the progression of OA by inhibiting oxidative stress. In this study, anterior cruciate ligament transection (ACLT)-induced OA mice received a diet supplemented with/without PQQ, and were compared with each other and with sham-operated mice. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456530PMC
March 2019
2 Reads

Low-dose tubacin promotes BMSCs proliferation and morphological changes through the ERK pathway.

Am J Transl Res 2019 15;11(3):1446-1459. Epub 2019 Mar 15.

Department of Pathophysiology, Guangdong Medical University Dongguan 523808, China.

Histone deacetylase 6 (HDAC6) plays critical roles in many cellular processes related to cancer, but its epigenetic regulation in bone marrow stromal stem cells (BMSCs) remains unexplored. This study investigated the beneficial effects of Tubulin Acetylation Inducer (tubacin), a novel specific HDAC6 inhibitor, on the proliferation and migration of BMSCs. A low concentration of tubacin promoted BMSC commitment and enhanced proliferation of BMSCs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456552PMC

Application of plasma circulating cell-free DNA detection to the molecular diagnosis of hepatocellular carcinoma.

Am J Transl Res 2019 15;11(3):1428-1445. Epub 2019 Mar 15.

Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases Beijing 100015, China.

Circulating tumor DNA (ctDNA) carries genetic information consistent with tumor cells and has potential value for molecular diagnosis of tumors. The present study analysed the gene mutations of plasma circulating cell-free DNA (cfDNA) and tumor tissue DNA in hepatocellular carcinoma (HCC) patients and explored the clinical application value of plasma cfDNA as a tumor marker in HCC molecular diagnosis. Samples from 29 patients with primary HCC were collected. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456549PMC
March 2019
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Comparison of various reagents for preparing a decellularized porcine cartilage scaffold.

Am J Transl Res 2019 15;11(3):1417-1427. Epub 2019 Mar 15.

Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, P. R. China.

Cartilage lesion repair is difficult due to the limited self-repair capability of cartilage and its lack of vascularization. Our previous study established a sandwich model for engineering cartilage with acellular cartilage sheets (ACSs) and chondrocytes. However, there is still debate over which agent achieves the optimal decellularization of cartilage sheets. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456528PMC

Prevascularized mesenchymal stem cell-sheets increase survival of random skin flaps in a nude mouse model.

Am J Transl Res 2019 15;11(3):1403-1416. Epub 2019 Mar 15.

Department of Burns Surgery, First Affiliated Hospital of Sun Yat-sen University Guangzhou, Guangdong, China.

A random skin flap is commonly applied in plastic and reconstructive surgery. The distal part of the random skin flap often risks necrosis because the blood flow may be compromised. Prevascularization is a widely used technology to intensify the vascularization function of biomaterials. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456548PMC

Artemether ameliorates type 2 diabetic kidney disease by increasing mitochondrial pyruvate carrier content in db/db mice.

Am J Transl Res 2019 15;11(3):1389-1402. Epub 2019 Mar 15.

Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine Shenzhen 518033, Guangdong, China.

Diabetic kidney disease (DKD), the leading cause of kidney failure, is characterized by albuminuria and renal hypertrophy. Metabolic alterations and mitochondrial dysfunction play critical roles in DKD initiation and progression. Artemether, a methyl ether derivative of artemisinin used for the treatment of malaria, has been identified as a putative candidate for treating diabetes, but its effect on DKD has not been studied. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456515PMC
March 2019
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TLR4/NF-κB axis signaling pathway-dependent up-regulation of miR-625-5p contributes to human intervertebral disc degeneration by targeting .

Am J Transl Res 2019 15;11(3):1374-1388. Epub 2019 Mar 15.

Department of Emergency Trauma Surgery, The First People's Hospital of Yunnan Province Kunming, Yunnan, China.

The activation of the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway has been found to play a critical role in many inflammatory diseases by controlling the expression of many cytokines. However, this pathway's role in the pathological process of intervertebral disc degeneration (IDD) has not been reported to date. In the present study, we found universal activation of the TLR4/NF-κB signaling pathway and elevated levels of pro-inflammatory cytokines in IDD patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456508PMC

Down-regulation of intracellular reactive oxygen species attenuates P-glycoprotein-associated chemoresistance in Epstein-Barr virus-positive NK/T-cell lymphoma.

Am J Transl Res 2019 15;11(3):1359-1373. Epub 2019 Mar 15.

Institute for Translational Research and Molecular Imaging, The Catholic University of Korea, College of Medicine Korea.

Epstein-Barr virus (EBV)-positive extranodal NK/T-cell lymphoma is a rare and highly aggressive disease with a poor prognosis and strong resistance to anti-cancer drugs. Reactive oxygen species (ROS) are closely related to tumorigenesis and P-glycoprotein (P-gp) is highly expressed in various cancers. However, the exact relationship between ROS and P-gp in EBV-positive lymphoma remains unclear. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456522PMC

Fetal bovine serum inhibits neomycin-induced apoptosis of hair cell-like HEI-OC-1 cells by maintaining mitochondrial function.

Am J Transl Res 2019 15;11(3):1343-1358. Epub 2019 Mar 15.

Department of Otolaryngology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University Nanjing 210008, China.

Aging and exposure to noise or ototoxic drugs are major causes of hair cell death leading to human hearing loss, and many agents have been developed to protect hair cells from apoptosis. Fetal bovine serum (FBS) is a fundamental ingredient in the culture medium of hair cell-like House Ear Institute Organ of Corti 1 (HEI-OC-1) cells, but there have been no reports about the function of FBS in HEI-OC-1 cell apoptosis. In this study, we found that FBS deprivation alone significantly increased HEI-OC-1 cell apoptosis in the absence of neomycin exposure and that the presence of FBS significantly inhibited HEI-OC-1 cell apoptosis after neomycin exposure compared to FBS-deprived cells. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456536PMC

Chemerin stimulates aortic smooth muscle cell proliferation and migration via activation of autophagy in VSMCs of metabolic hypertension rats.

Am J Transl Res 2019 15;11(3):1327-1342. Epub 2019 Mar 15.

Department of Cardiology of The Third Xiangya Hospital, Central South University Changsha, China.

Vascular remodeling is a characteristic pathogenesis of hypertension and a main cause of abnormal construction and function of organs because of hypertension. Chemerin is a new adipokine that is elevated in states of obesity and metabolic syndrome (MS). However, the molecular mechanisms behind these pathological processes are not fully clarified. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456550PMC
March 2019
1 Read