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    2606 results match your criteria American journal of therapeutics[Journal]

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    Error in Drugs Consumption Among Older Patients.
    Am J Ther 2017 Nov/Dec;24(6):e701-e705
    1Diabetes Unit, Edith Wolfson Medical Center, Holon, Israel;2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;3Department of Medicine, Wolfson Medical Center, Holon, Israel;4Epidemiology and Research Unit, Wolfson Medical Center, Holon, Israel; and5Department of Nutrition, School of Health Sciences, Ariel University, Ariel, Israel.
    The cost effectiveness of generic drugs has promoted their use worldwide. However, the large variety of bioequivalent generic and brand-name drugs found in the marketplace increases the complexity and frequency of mistakes in drug consumption. This clinical study investigated the prevalence of various mistakes in drug consumption by patients using a hospital setting. Read More

    Which Combination Treatment Is Better for Spinal Metastasis, Percutaneous Vertebroplasty With Radiofrequency Ablation, 125I Seed, Zoledronic Acid, or Radiotherapy?
    Am J Ther 2017 Apr 26. Epub 2017 Apr 26.
    Department of Orthopaedics (Spine), Changhai Hospital, Shanghai, China.
    Background: Percutaneous vertebroplasty (PVP) can not only alleviate pain but also restore mechanical stability with injection of bone cement, whereas it exhibits a poor effect on antitumor activity. But through combinations with other therapies, it may be possible to achieve the maximum effect in clinical treatment. Thus, this study is designed to assess the clinical efficacy of PVP separately combined with 4 ways for spinal metastasis (SM) treatment. Read More

    Management of Gastric Cancer With Umbilical Metastasis: A Case Report.
    Am J Ther 2017 Oct 20. Epub 2017 Oct 20.
    1Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China; Departments of 2Gastrointestinal Surgery and 3Medical Imaging, The Affiliated Hospital of Putian University, Putian, China; and 4The George Institute for Global Health, Sydney Medical School, University of Sydney, Camperdown, Australia.

    Abatacept Monotherapy Versus Abatacept Plus Methotrexate for Treatment-Refractory Rheumatoid Arthritis.
    Am J Ther 2017 Sep 12. Epub 2017 Sep 12.
    1Department of Rheumatology, Saint-Philibert Hospital, Lille University, Lomme, France; 2Department of Rheumatology, University-Hospital of Lille, Lille Cedex, France; 3EA 4490, University-Hospital of Lille, Lille Cedex, France; 4Department of Biostatistics, EA2694, University of Lille, CHRU Lille, Lille, France; and 5Department of Rheumatology, Valenciennes Hospital, Valenciennes, France.
    Background: Methotrexate combination therapy improves abatacept efficacy as a first-line biologic agent for the treatment of rheumatoid arthritis, but it is unclear when abatacept is used later on, particularly after non-TNF inhibitor (TNFi) failure.

    Study Question: The objective of this study was to determine whether treatment response after non-TNFi inadequate response is different in patients with rheumatoid arthritis (RA) treated with abatacept in combination with or not with methotrexate.

    Methods: Patients treated with abatacept monotherapy or in combination with methotrexate after non-TNFi failure were included. Read More

    Homeopathy as Boundary Object and Distributed Therapeutic Agency. A Discussion on the Homeopathic Placebo Response.
    Am J Ther 2017 Sep 27. Epub 2017 Sep 27.
    1Department of Sociology, Faculty of Sociology and Social Work, University of Bucharest, Bucharest, Romania; and 2Intensive Care Unit - Clinical Toxicology, Bucharest, Romania.
    Background: We discuss homeopathy's placebo effect as the result of a distributed therapeutic agency involving humans, objects, and texts. Homeopathy has been involved in controversies for centuries, and the dispute whether it is therapy or quackery is as lively as ever. Still, homeopathy has retained significant popularity and acceptance within the medical establishment. Read More

    Effect of High-Dose Allopurinol Pretreatment on Cardiac Biomarkers of Patients Undergoing Elective Percutaneous Coronary Intervention: A Randomized Clinical Trial.
    Am J Ther 2017 Nov/Dec;24(6):e723-e729
    1Department of Cardiology, Rajaiee Heart Center, Iran University of Medical Sciences, Tehran, Iran; 2Department of Cardiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 4Resident of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Departments of 5Research; 6Epidemiology and Biostatistics, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran; and 7Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Increased accumulation of reactive oxygen species contributes to pathophysiologic states such as endothelial dysfunction, metabolic and functional impairment, inflammatory activation, and other features of cardiovascular pathophysiology. Allopurinol acts as a xanthine oxidase inhibitor that reduces the amount of free radicals after reactive oxygen species generation.

    Methods And Results: In this placebo-controlled randomized clinical trial, all patients admitted with coronary artery disease who are candidates for elective percutaneous coronary intervention (PCI) were included. Read More

    Emergency Department Treatment of Cannabinoid Hyperemesis Syndrome: A Review.
    Am J Ther 2017 Sep 11. Epub 2017 Sep 11.
    Department of Emergency Medicine, Cook County Health and Hospitals System, Chicago, IL.
    Background: Cannabinoid hyperemesis syndrome (CHS) is a syndrome of cyclic vomiting associated with chronic cannabis use. As cannabis consumption steadily increases each year, CHS is becoming a commonplace and costly occurrence in hospitals nationwide. Currently, there are no best treatment strategies agreed upon universally. Read More

    Therapeutic Outcome of Achalasia Based on High-Resolution Manometry: A Korean Multicenter Study.
    Am J Ther 2017 Sep 11. Epub 2017 Sep 11.
    1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; 3Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University College of Medicine, Seoul, Korea; 4Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; 5Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea; and 6Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
    Background: Because achalasia subtype is associated with therapeutic response, it is possible that regional differences in subtype distribution could lead to differences in therapeutic outcomes.

    Study Question: We aimed to evaluate and compare high-resolution manometry (HRM) profiles among the different subtypes of achalasia and to elucidate predictive factors associated with treatment outcomes.

    Study Design: Patients who were diagnosed with achalasia using HRM at 4 Korean university hospitals were retrospectively identified and analyzed. Read More

    Atezolizumab-Induced New Onset Diabetes Mellitus With Ketoacidosis.
    Am J Ther 2017 Sep 11. Epub 2017 Sep 11.
    Departments of 1Internal Medicine, 2Pediatric Endocrinology, and 3Hematology and Oncology, Maimonides Medical Center, Brooklyn, NY 4Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York City, NY.

    Acute Opiate Overdose: An Update on Management Strategies in Emergency Department and Critical Care Unit.
    Am J Ther 2017 Sep 13. Epub 2017 Sep 13.
    1Department of Internal Medicine, Forest Hills Hospital, New York, NY; and 2Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Hofstra Northwell School of Medicine, North Shore University Hospital & Long Island Jewish Medical Center, New Hyde Park, NY.
    Background: Opioids are natural, semisynthetic, or synthetic substances that act on opioid receptors in the central nervous system. Clinically, they are prescribed for pain management. Opioid overdose (OOD) occurs when the central nervous system and respiratory drive are suppressed because of excessive consumption of the drug. Read More

    Regorafenib Treatment for Management of Colorectal Cancer: A Systematic Review and Meta-analysis of 6 Randomized Controlled Trials.
    Am J Ther 2017 Sep 21. Epub 2017 Sep 21.
    1Department of Tumor Institute, Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China 2Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China Departments 3of Clinical Cancer Research Center of Combination of Traditional Chinese and Western Medicine 4Radiotherapy 5Thoracic Surgery, Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China 6Department of Organ Transplantation Center, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.

    Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms.
    Am J Ther 2017 Mar 27. Epub 2017 Mar 27.
    1Department of Food Science, Louisiana State University Agricultural Center, Baton Rouge, LA; 2Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; and 3BASF Corporation San Gabriel, LA.
    Background: Insomnia is common in the elderly and is associated with chronic disease, but use of hypnotics increases the incidence of falls. Montmorency tart cherry juice has improved insomnia by self-report questionnaire.

    Study Question: Is insomnia confirmed by polysomnography and is tryptophan availability a potential mechanism for treating insomnia?

    Study Design: A placebo-controlled balanced crossover study with subjects older than 50 years and insomnia were randomized to placebo (2 weeks) or cherry juice (2 weeks) (240 mL 2 times/d) separated by a 2-week washout. Read More

    Effect of Citalopram for the Treatment of Neurocardiogenic Syncope.
    Am J Ther 2017 Aug 16. Epub 2017 Aug 16.
    1Cleveland Clinic Foundation, Cleveland, OH; 2The Integrated Center for Cardiovascular and Electrical Diseases, Amman, Jordan; 3Baylor Scott and White Memorial Hospital, Temple, TX; 4University of Connecticut/Hartford Hospital, Hartford, CT; 5Univerisdad Peruana de Ciencias Aplicadas (UPC), Lima, Peru; and 6Jordan Hospital & Medical Center, Amman, Jordan.
    Background: Neurocardiogenic syncope (NCS) is a common form of syncope. Although selective serotonin reuptake inhibitors and other medications have been used to treat NCS with variable success, there is no consensus regarding a first-line therapy.

    Study Question: To assess the effects of citalopram in NCS and to examine the effect of diagnostic use of the head-up tilt table (HUTT) versus empirical diagnosis on patient outcome. Read More

    Multiple Drug-Intolerant Hypertension.
    Am J Ther 2017 Sep/Oct;24(5):e588-e591
    1Department of Fundamental, Prophylactic and Clinical Sciences, Faculty of Medicine, University Transilvania Braşov; and 2County Hospital Brasov, Romania.
    Clinical Features: The term multiple drug intolerance (MDI) is attributed to patients who experience adverse drug reactions to more than 3 different classes of medication without a known immunological mechanism. A special attention should be given to multiple drug-intolerant hypertension (MDI-HTN) that is a cause of drop out from treatment and consequent poor blood pressure control. Patients with MDIs account for 2%-5% of all population. Read More

    Ultrasonographic Assessment of Bladder Volumes in Children Undergoing Penile Surgery: Does the Type of Anesthesia Matter?
    Am J Ther 2017 Jul 17. Epub 2017 Jul 17.
    Departments of 1Anesthesiology and Critical Care Medicine and 2Urology-Pediatric Urology Unit, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
    Background: There are scant data reporting postoperative ultrasonographically measured bladder volumes in children undergoing penile surgery.

    Study Question: We studied the effect of various anesthesia techniques on return of micturition after penile surgery in children, using ultrasonographically measured bladder volumes.

    Data Sources: Ultrasonographically measured postvoiding residual bladder volumes indexed to age-appropriate capacity, and time elapsed between the end of surgery and spontaneous voiding after pediatric circumcision, distal hypospadias repair, or repair of urethrocutaneous fistula, were studied. Read More

    Comparison of 3-Factor Versus 4-Factor Prothrombin Complex Concentrate With Regard to Warfarin Reversal, Blood Product Use, and Costs.
    Am J Ther 2017 Jul 26. Epub 2017 Jul 26.
    1Department of Pharmacy Services, Banner-University Medical Center Tucson, Tucson, AZ; 2Department of Pharmacy Practice & Science, College of Pharmacy, The University of Arizona, Tucson, AZ.
    Background: Prothrombin complex concentrates (PCCs) are drug products containing varying amounts of vitamin K-dependent coagulation factors II, VII, IX, and X. The evidence comparing 3-factor PCC (3-PCC) versus 4-factor PCC (4-PCC) for warfarin reversal is conflicting. It has been hypothesized that 3-PCC may be less effective than 4-PCC because of relatively lower factor VII content. Read More

    Efficacy and Safety of Proton Pump Inhibitors in the Long-Term Aspirin Users: A Meta-Analysis of Randomized Controlled Trials.
    Am J Ther 2017 Sep/Oct;24(5):e559-e569
    1Louisiana State University Health Science Center, Department of Medicine, Division of Cardiology, Shreveport, LA; and 2Department of Medicine, Lakes Region General Healthcare, University of New England, Laconia, NH.
    Background: Long-term aspirin use in cardiovascular disease prevention may result in gastrointestinal bleeding. Although proton pump inhibitors (PPI) have been shown to reduce the risks of peptic ulcers and dyspeptic symptoms in long-term aspirin users in the randomized controlled trials, there are safety concerns about the long-term use of PPI.

    Study Question: What is the safety and efficacy of PPI in patients using aspirin in long term for prevention of cardiovascular diseases and stroke?

    Methods: We searched MEDLINE, EMBASE, CENTRAL, CINAHL, ProQuest, and relevant references from inception through February 2015, and used random-effects model for meta-analysis. Read More

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