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    2587 results match your criteria American journal of therapeutics[Journal]

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    Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms.
    Am J Ther 2017 Mar 27. Epub 2017 Mar 27.
    1Department of Food Science, Louisiana State University Agricultural Center, Baton Rouge, LA; 2Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; and 3BASF Corporation San Gabriel, LA.
    Background: Insomnia is common in the elderly and is associated with chronic disease, but use of hypnotics increases the incidence of falls. Montmorency tart cherry juice has improved insomnia by self-report questionnaire.

    Study Question: Is insomnia confirmed by polysomnography and is tryptophan availability a potential mechanism for treating insomnia?

    Study Design: A placebo-controlled balanced crossover study with subjects older than 50 years and insomnia were randomized to placebo (2 weeks) or cherry juice (2 weeks) (240 mL 2 times/d) separated by a 2-week washout. Read More

    Effect of Citalopram for the Treatment of Neurocardiogenic Syncope.
    Am J Ther 2017 Aug 16. Epub 2017 Aug 16.
    1Cleveland Clinic Foundation, Cleveland, OH; 2The Integrated Center for Cardiovascular and Electrical Diseases, Amman, Jordan; 3Baylor Scott and White Memorial Hospital, Temple, TX; 4University of Connecticut/Hartford Hospital, Hartford, CT; 5Univerisdad Peruana de Ciencias Aplicadas (UPC), Lima, Peru; and 6Jordan Hospital & Medical Center, Amman, Jordan.
    Background: Neurocardiogenic syncope (NCS) is a common form of syncope. Although selective serotonin reuptake inhibitors and other medications have been used to treat NCS with variable success, there is no consensus regarding a first-line therapy.

    Study Question: To assess the effects of citalopram in NCS and to examine the effect of diagnostic use of the head-up tilt table (HUTT) versus empirical diagnosis on patient outcome. Read More

    Multiple Drug-Intolerant Hypertension.
    Am J Ther 2017 Sep/Oct;24(5):e588-e591
    1Department of Fundamental, Prophylactic and Clinical Sciences, Faculty of Medicine, University Transilvania Braşov; and 2County Hospital Brasov, Romania.
    Clinical Features: The term multiple drug intolerance (MDI) is attributed to patients who experience adverse drug reactions to more than 3 different classes of medication without a known immunological mechanism. A special attention should be given to multiple drug-intolerant hypertension (MDI-HTN) that is a cause of drop out from treatment and consequent poor blood pressure control. Patients with MDIs account for 2%-5% of all population. Read More

    Ultrasonographic Assessment of Bladder Volumes in Children Undergoing Penile Surgery: Does the Type of Anesthesia Matter?
    Am J Ther 2017 Jul 17. Epub 2017 Jul 17.
    Departments of 1Anesthesiology and Critical Care Medicine and 2Urology-Pediatric Urology Unit, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
    Background: There are scant data reporting postoperative ultrasonographically measured bladder volumes in children undergoing penile surgery.

    Study Question: We studied the effect of various anesthesia techniques on return of micturition after penile surgery in children, using ultrasonographically measured bladder volumes.

    Data Sources: Ultrasonographically measured postvoiding residual bladder volumes indexed to age-appropriate capacity, and time elapsed between the end of surgery and spontaneous voiding after pediatric circumcision, distal hypospadias repair, or repair of urethrocutaneous fistula, were studied. Read More

    Comparison of 3-Factor Versus 4-Factor Prothrombin Complex Concentrate With Regard to Warfarin Reversal, Blood Product Use, and Costs.
    Am J Ther 2017 Jul 26. Epub 2017 Jul 26.
    1Department of Pharmacy Services, Banner-University Medical Center Tucson, Tucson, AZ; 2Department of Pharmacy Practice & Science, College of Pharmacy, The University of Arizona, Tucson, AZ.
    Background: Prothrombin complex concentrates (PCCs) are drug products containing varying amounts of vitamin K-dependent coagulation factors II, VII, IX, and X. The evidence comparing 3-factor PCC (3-PCC) versus 4-factor PCC (4-PCC) for warfarin reversal is conflicting. It has been hypothesized that 3-PCC may be less effective than 4-PCC because of relatively lower factor VII content. Read More

    Efficacy and Safety of Proton Pump Inhibitors in the Long-Term Aspirin Users: A Meta-Analysis of Randomized Controlled Trials.
    Am J Ther 2017 Sep/Oct;24(5):e559-e569
    1Louisiana State University Health Science Center, Department of Medicine, Division of Cardiology, Shreveport, LA; and 2Department of Medicine, Lakes Region General Healthcare, University of New England, Laconia, NH.
    Background: Long-term aspirin use in cardiovascular disease prevention may result in gastrointestinal bleeding. Although proton pump inhibitors (PPI) have been shown to reduce the risks of peptic ulcers and dyspeptic symptoms in long-term aspirin users in the randomized controlled trials, there are safety concerns about the long-term use of PPI.

    Study Question: What is the safety and efficacy of PPI in patients using aspirin in long term for prevention of cardiovascular diseases and stroke?

    Methods: We searched MEDLINE, EMBASE, CENTRAL, CINAHL, ProQuest, and relevant references from inception through February 2015, and used random-effects model for meta-analysis. Read More

    Cefepime Associated With Phenytoin Induced Stevens-Johnson Syndrome.
    Am J Ther 2017 Jul/Aug;24(4):e481-e484
    1Pharmacy Department, Gerencia de Atención Integrada, Albacete, Spain; and2Surgical Intensive Care Unit, Gerencia de Atención Integrada, Albacete, Spain.
    We describe a recent case of Stevens-Johnson Syndrome. A 49-year-old man was admitted to the Intensive Care Unit of an Anaesthesia and Resuscitation Department because of a Fournier gangrene that derived in a sepsis, ventilator-associated pneumonia, and renal failure. He was under treatment with cefepime and suffered a generalized status epilepticus, so started treatment with phenytoin. Read More

    Vitamin K Antagonists Versus Novel Oral Anticoagulants for Elective Electrical Cardioversion of Atrial Fibrillation.
    Am J Ther 2017 Sep/Oct;24(5):e553-e558
    1Faculty of Medicine, "Transilvania" University, Braşov, Romania; 2ICCO Clinics, Braşov, Romania; 3"Grigore T. Popa" University of Medicine and Pharmacy Iaşi, Iaşi, Romania; and 4Cardiology Department, Cardiology Clinic, "St. Spiridon" County Emergency Hospital, Iaşi, Romania.
    Background: The management strategy for patients with atrial fibrillation (AF) is often very complex, electrical cardioversion (EC) being often used to restore sinus rhythm in those patients. The increased risk of thromboembolic complications was lowered using anticoagulation therapy. Usually, the anticoagulation was achieved using vitamin K antagonists (VKAs), but over the last years we witnessed a wide implementation of the novel oral anticoagulants (NOACs). Read More

    Comparison Between 2 Electronic Databases to Evaluate Potential Drug-Drug Interactions in Prescriptions of Surgical Patients.
    Am J Ther 2017 Jun 20. Epub 2017 Jun 20.
    1Doctorado en Farmacología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México 2Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México 3Departamento de Ciencias Médicas y de la Vida, Centro Universitario de la Ciénega, Universidad de Guadalajara, Guadalajara, Jalisco, México.

    Cardiac Dysrhythmias Associated With Substitutive Use of Loperamide: A Systematic Review.
    Am J Ther 2017 Apr 27. Epub 2017 Apr 27.
    1Department of Internal Medicine, University of Arizona, Tucson, AZ;2Department of Internal Medicine, Dow University of Health Sciences, Pakistan;3Department of Internal Medicine, Mount Sinai School of Medicine, New York, NY; and4Department of Pharmacy, College of Pharmacy, University of Arizona, Tucson, AZ.
    Background: Recently, several deaths secondary to cardiac arrhythmias have been reported in association with substitutive use of loperamide. Therefore, we conducted a systematic review of all reported cases to overview the epidemiologic patterns and clinical outcomes to better elucidate loperamide-induced cardiac complications.

    Areas Of Uncertainty: Association between substitutive use of loperamide and cardiac arrhythmias. Read More

    Magnesium Supplementation in Vitamin D Deficiency.
    Am J Ther 2017 May 3. Epub 2017 May 3.
    Division of General Internal Medicine, UF Health Jacksonville, Jacksonville, FL.
    Background: Vitamin D and magnesium (Mg) are some of the most studied topics in medicine with enormous implications for human health and disease. Majority of the adults are deficient in both vitamin D and magnesium but continue to go unrecognized by many health care professionals.

    Areas Of Uncertainty: Mg and vitamin D are used by all the organs in the body, and their deficiency states may lead to several chronic medical conditions. Read More

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