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    2644 results match your criteria American journal of therapeutics[Journal]

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    Intravenous Lidocaine for Intractable Renal Colic Unresponsive to Standard Therapy.
    Am J Ther 2018 Feb 13. Epub 2018 Feb 13.
    Department of Emergency Medicine, The Brooklyn Hospital Center, Brooklyn, NY.
    Clinical Features: Renal colic is defined as a flank pain radiating to the groin caused by kidney stones in the ureter (urolithiasis). Renal colic is a frequent cause of Emergency Department visits. Most renal colic cases present as acute distress and severe back and/or abdominal pain that require prompt treatment with analgesics. Read More

    Effect of Treating Vitamin D Deficiency in Uncontrolled Type 2 Diabetes: A Randomized, Placebo-Controlled Study.
    Am J Ther 2018 Feb 5. Epub 2018 Feb 5.
    Background: Literature increasingly supports the inverse relationship of vitamin D (VitD) level and type 2 diabetes (T2DM). Proposed protective mechanisms of VitD include its anti-inflammatory effects, increased insulin secretion via pancreatic β-cell stimulation, and downregulation of parathyroid hormone levels. Interventional studies show mixed results of VitD therapy in prediabetic patients with VitD deficiency or diabetic patients with normal VitD levels. Read More

    Clozapine for Treatment-Refractory Behavioral Disturbance in Dementia.
    Am J Ther 2018 Jan 31. Epub 2018 Jan 31.
    Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania.
    Background: Behavioral and psychological symptoms in dementia significantly contribute to caregiver burden and impose patient hospitalization. The goal of treatment of admitted patients is the rapid remission of symptoms to allow their return to home as soon as possible. Intervention requires an intrusive approach with parenteral treatment and physical restraints, with a negative emotional impact on patients and their families. Read More

    Fractures Related to Tenofovir: A Case/Noncase Study in the European Pharmacovigilance Database.
    Am J Ther 2018 Jan 8. Epub 2018 Jan 8.
    Basque Country Pharmacovigilance Unit, Galdakao-Usansolo Hospital, Galdakao, Spain.
    Background: There is no clear consensus on the relationship between tenofovir (TDF) and fracture risk because the studies published so far present contradictory findings.

    Study Question: Our objective was to detect, from the European pharmacovigilance database (EudraVigilance), a signal of fracture risk during TDF exposure in patients infected with HIV.

    Methods: Herein, we analyze all the cases of fractures suspected to be related to TDF recorded in EudraVigilance between 2001 and November 10, 2016. Read More

    Bortezomib for Refractory Immune-Mediated Thrombocytopenia Purpura.
    Am J Ther 2017 Jan 7. Epub 2017 Jan 7.
    Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC.
    The treatment of refractory immune-mediated thrombocytopenia purpura (ITP) can be challenging. This case report describes treatment of refractory ITP with bortezomib, a proteasome inhibitor. This strategy has been successful in relapsing thrombotic thrombocytopenic purpura but is a novel therapeutic approach for ITP. Read More

    The Effects of Known Cardioprotective Drugs on Proinflammatory Cytokine Secretion From Human Coronary Artery Endothelial Cells.
    Am J Ther 2017 Nov 27. Epub 2017 Nov 27.
    Background: Endothelial cell dysfunction in diabetes is involved in the pathogenesis and progression of premature atherosclerosis. High-dextrose has been shown to induce both oxidative stress and endoplasmic reticulum stress in cultured human coronary artery endothelial cells (HCAEC).

    Study Question: To determine whether or not several classes of cardioprotective drugs inhibit proinflammatory cytokine expression by HCAEC. Read More

    Levocarnitine for the Treatment of Valproic Acid-Induced Hyperammonemic Encephalopathy in Children: The Experience of Large, Tertiary Care Pediatric Hospital and a Poison Center.
    Am J Ther 2017 Nov 22. Epub 2017 Nov 22.
    Denver Health and Hospital Authority, Rocky Mountain Poison and Drug Center, Denver, CO.
    Background: Although rare, symptomatic hyperammonemia is sometimes associated with valproic acid (VPA), especially in children. L-carnitine (levocarnitine), sometimes classified as an essential amino acid, is vital to mitochondrial utilization of fatty acids and can be helpful in treating this condition. The data supporting this, however, are limited. Read More

    Selected Food/Herb-Drug Interactions: Mechanisms and Clinical Relevance.
    Am J Ther 2017 Nov 22. Epub 2017 Nov 22.
    Clinical Pharmacy and Management, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Rivers State, Nigeria.
    Background: Food/Herb-drug interactions have become a major problem in health care. These interactions can lead to loss of therapeutic efficacy or toxic effects of drugs.

    Areas Of Uncertainty: To probe the clinical relevance of such interactions, the impact of food/herb intake on the clinical effects of drug administration has to be evaluated. Read More

    Fingolimod-Associated Intracerebral Lymphoproliferative Disorder.
    Am J Ther 2017 Oct 27. Epub 2017 Oct 27.
    Partners MS Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
    Most epidemiological studies indicate that incidence of cancer in multiple sclerosis patients is lower than general population. However these studies were performed prior to the emergence of disease-modifying therapies (DMTs). The incidence of cancer may be influenced by newer generation DMTs which are immunomodulatory or immunosuppressant. Read More

    Hypoglycemia and Sudden Death During Treatment With Methadone for Opiate Detoxification.
    Am J Ther 2017 Nov 14. Epub 2017 Nov 14.
    Hofstra Northwell School of Medicine, Hempstead, NY.
    Clinical Features: We present a case of a middle-aged man admitted to an inpatient detoxification facility for withdrawal of intranasal heroin, alprazolam, and ethanol. The patient was placed on methadone and chlordiazepoxide tapers. Ondansetron and trazodone were prescribed as needed for symptom control. Read More

    Role of Preemptive Gabapentin on Postoperative Analgesia After Infraumbilical Surgeries Under Subarachnoid Block-A Randomized, Placebo-Controlled, Double-Blind Study.
    Am J Ther 2017 Nov 14. Epub 2017 Nov 14.
    Background: Preemptive use of gabapentin might accelerate recovery by reducing acute post-inguinal herniorrhaphy pain and opioid requirement being an analgesic.

    Study Question: Assessing efficacy of three different doses of oral gabapentin premedication for postoperative pain management after inguinal herniorrhaphy under spinal anesthesia.

    Study Design: This prospective, randomized, placebo controlled study was performed on 120 male patients (ASA I/II) undergoing inguinal herniorrhaphy under subarachnoid block. Read More

    Muscle Damage Due to Fusidic Acid-Statin Interaction: Review of 75 Cases From the French Pharmacovigilance Database and Literature Reports.
    Am J Ther 2017 Nov 9. Epub 2017 Nov 9.
    Internal Medicine Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
    Background/area Of Uncertainty: Statins, which reduce cardiovascular risk in both primary and secondary prevention, are one of the most widely prescribed therapeutic classes in the world. Usually well-tolerated, statin-associated muscle symptoms are a well-known adverse effect. Fusidic acid (FA) is a bacteriostatic antibiotic of interest in the treatment of methicillin-resistant Staphylococcus aureus infections. Read More

    Error in Drugs Consumption Among Older Patients.
    Am J Ther 2017 Nov/Dec;24(6):e701-e705
    1Diabetes Unit, Edith Wolfson Medical Center, Holon, Israel;2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;3Department of Medicine, Wolfson Medical Center, Holon, Israel;4Epidemiology and Research Unit, Wolfson Medical Center, Holon, Israel; and5Department of Nutrition, School of Health Sciences, Ariel University, Ariel, Israel.
    The cost effectiveness of generic drugs has promoted their use worldwide. However, the large variety of bioequivalent generic and brand-name drugs found in the marketplace increases the complexity and frequency of mistakes in drug consumption. This clinical study investigated the prevalence of various mistakes in drug consumption by patients using a hospital setting. Read More

    Which Combination Treatment Is Better for Spinal Metastasis, Percutaneous Vertebroplasty With Radiofrequency Ablation, 125I Seed, Zoledronic Acid, or Radiotherapy?
    Am J Ther 2017 Apr 26. Epub 2017 Apr 26.
    Department of Orthopaedics (Spine), Changhai Hospital, Shanghai, China.
    Background: Percutaneous vertebroplasty (PVP) can not only alleviate pain but also restore mechanical stability with injection of bone cement, whereas it exhibits a poor effect on antitumor activity. But through combinations with other therapies, it may be possible to achieve the maximum effect in clinical treatment. Thus, this study is designed to assess the clinical efficacy of PVP separately combined with 4 ways for spinal metastasis (SM) treatment. Read More

    Management of Gastric Cancer With Umbilical Metastasis: A Case Report.
    Am J Ther 2017 Oct 20. Epub 2017 Oct 20.
    1Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China; Departments of 2Gastrointestinal Surgery and 3Medical Imaging, The Affiliated Hospital of Putian University, Putian, China; and 4The George Institute for Global Health, Sydney Medical School, University of Sydney, Camperdown, Australia.

    Macitentan Use in a Neurofibromatosis Type 1 Patient With Pulmonary Hypertension and External Jugular Phlebectasia.
    Am J Ther 2017 Oct 20. Epub 2017 Oct 20.
    1Department of Cardiology, Ospedali Riuniti University Hospital, Foggia, Italy 2Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

    Abatacept Monotherapy Versus Abatacept Plus Methotrexate for Treatment-Refractory Rheumatoid Arthritis.
    Am J Ther 2017 Sep 12. Epub 2017 Sep 12.
    1Department of Rheumatology, Saint-Philibert Hospital, Lille University, Lomme, France; 2Department of Rheumatology, University-Hospital of Lille, Lille Cedex, France; 3EA 4490, University-Hospital of Lille, Lille Cedex, France; 4Department of Biostatistics, EA2694, University of Lille, CHRU Lille, Lille, France; and 5Department of Rheumatology, Valenciennes Hospital, Valenciennes, France.
    Background: Methotrexate combination therapy improves abatacept efficacy as a first-line biologic agent for the treatment of rheumatoid arthritis, but it is unclear when abatacept is used later on, particularly after non-TNF inhibitor (TNFi) failure.

    Study Question: The objective of this study was to determine whether treatment response after non-TNFi inadequate response is different in patients with rheumatoid arthritis (RA) treated with abatacept in combination with or not with methotrexate.

    Methods: Patients treated with abatacept monotherapy or in combination with methotrexate after non-TNFi failure were included. Read More

    Homeopathy as Boundary Object and Distributed Therapeutic Agency. A Discussion on the Homeopathic Placebo Response.
    Am J Ther 2017 Sep 27. Epub 2017 Sep 27.
    1Department of Sociology, Faculty of Sociology and Social Work, University of Bucharest, Bucharest, Romania; and 2Intensive Care Unit - Clinical Toxicology, Bucharest, Romania.
    Background: We discuss homeopathy's placebo effect as the result of a distributed therapeutic agency involving humans, objects, and texts. Homeopathy has been involved in controversies for centuries, and the dispute whether it is therapy or quackery is as lively as ever. Still, homeopathy has retained significant popularity and acceptance within the medical establishment. Read More

    Effect of High-Dose Allopurinol Pretreatment on Cardiac Biomarkers of Patients Undergoing Elective Percutaneous Coronary Intervention: A Randomized Clinical Trial.
    Am J Ther 2017 Nov/Dec;24(6):e723-e729
    1Department of Cardiology, Rajaiee Heart Center, Iran University of Medical Sciences, Tehran, Iran; 2Department of Cardiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 4Resident of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Departments of 5Research; 6Epidemiology and Biostatistics, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran; and 7Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Increased accumulation of reactive oxygen species contributes to pathophysiologic states such as endothelial dysfunction, metabolic and functional impairment, inflammatory activation, and other features of cardiovascular pathophysiology. Allopurinol acts as a xanthine oxidase inhibitor that reduces the amount of free radicals after reactive oxygen species generation.

    Methods And Results: In this placebo-controlled randomized clinical trial, all patients admitted with coronary artery disease who are candidates for elective percutaneous coronary intervention (PCI) were included. Read More

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